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Steven Kliewer

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
Potthoff Matthew J; Inagaki Takeshi; Satapati Santhosh; Ding Xunshan; He Tianteng; Goetz Regina; Mohammadi Moosa; Finck Brian N; Mangelsdorf David J; Kliewer Steven A; Burgess Shawn C
FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response.
Wang Zhu; Zhou X Edward; Motola Daniel L; Gao Xin; Suino-Powell Kelly; Conneely Aoife; Ogata Craig; Sharma Kamalesh K; Auchus Richard J; Lok James B; Hawdon John M; Kliewer Steven A; Xu H Eric; Mangelsdorf David J
Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes.
Sun Tingwan; Fu Mingui; Bookout Angie L; Kliewer Steven A; Mangelsdorf David J
MicroRNA let-7 regulates 3T3-L1 adipogenesis.

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All Publications

2009: Potthoff Matthew J; Inagaki Takeshi; Satapati Santhosh; Ding Xunshan; He Tianteng; Goetz Regina; Mohammadi Moosa; Finck Brian N; Mangelsdorf David J; Kliewer Steven A; Burgess Shawn C
FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(26):10853-8.
2009: Wang Zhu; Zhou X Edward; Motola Daniel L; Gao Xin; Suino-Powell Kelly; Conneely Aoife; Ogata Craig; Sharma Kamalesh K; Auchus Richard J; Lok James B; Hawdon John M; Kliewer Steven A; Xu H Eric; Mangelsdorf David J
Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(23):9138-43.
2009: Sun Tingwan; Fu Mingui; Bookout Angie L; Kliewer Steven A; Mangelsdorf David J
MicroRNA let-7 regulates 3T3-L1 adipogenesis.
Molecular endocrinology (Baltimore, Md.) 2009;23(6):925-31.
2008: Teotico Denise G; Bischof Jason J; Peng Li; Kliewer Steven A; Redinbo Matthew R
Structural basis of human pregnane X receptor activation by the hops constituent colupulone.
Molecular pharmacology 2008;74(6):1512-20.
2008: Satapati Santhosh; He Tianteng; Inagaki Takeshi; Potthoff Matthew; Merritt Matthew E; Esser Victoria; Mangelsdorf David J; Kliewer Steven A; Browning Jeffrey D; Burgess Shawn C
Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism.
Diabetes 2008;57(8):2012-21.
2008: Inagaki Takeshi; Lin Vicky Y; Goetz Regina; Mohammadi Moosa; Mangelsdorf David J; Kliewer Steven A
Inhibition of growth hormone signaling by the fasting-induced hormone FGF21.
Cell metabolism 2008;8(1):77-83.
2008: Lee Youn-Kyoung; Schmidt Daniel R; Cummins Carolyn L; Choi Mihwa; Peng Li; Zhang Yuan; Goodwin Bryan; Hammer Robert E; Mangelsdorf David J; Kliewer Steven A
Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis.
Molecular endocrinology (Baltimore, Md.) 2008;22(6):1345-56.
2008: Zhao Guixiang; Jeoung Nam Ho; Burgess Shawn C; Rosaaen-Stowe Kimberly A; Inagaki Takeshi; Latif Shuaib; Shelton John M; McAnally John; Bassel-Duby Rhonda; Harris Robert A; Richardson James A; Kliewer Steven A
Overexpression of pyruvate dehydrogenase kinase 4 in heart perturbs metabolism and exacerbates calcineurin-induced cardiomyopathy.
American journal of physiology. Heart and circulatory physiology 2008;294(2):H936-43.
2007: Jung Diana; Inagaki Takeshi; Gerard Robert D; Dawson Paul A; Kliewer Steven A; Mangelsdorf David J; Moschetta Antonio
FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption.
Journal of lipid research 2007;48(12):2693-700.
2007: Kurosu Hiroshi; Choi Mihwa; Ogawa Yasushi; Dickson Addie S; Goetz Regina; Eliseenkova Anna V; Mohammadi Moosa; Rosenblatt Kevin P; Kliewer Steven A; Kuro-o Makoto
Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21.
The Journal of biological chemistry 2007;282(37):26687-95.
2007: Inagaki Takeshi; Dutchak Paul; Zhao Guixiang; Ding Xunshan; Gautron Laurent; Parameswara Vinay; Li Yong; Goetz Regina; Mohammadi Moosa; Esser Victoria; Elmquist Joel K; Gerard Robert D; Burgess Shawn C; Hammer Robert E; Mangelsdorf David J; Kliewer Steven A
Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21.
Cell metabolism 2007;5(6):415-25.
2007: Goetz Regina; Beenken Andrew; Ibrahimi Omar A; Kalinina Juliya; Olsen Shaun K; Eliseenkova Anna V; Xu ChongFeng; Neubert Thomas A; Zhang Fuming; Linhardt Robert J; Yu Xijie; White Kenneth E; Inagaki Takeshi; Kliewer Steven A; Yamamoto Masaya; Kurosu Hiroshi; Ogawa Yasushi; Kuro-o Makoto; Lanske Beate; Razzaque Mohammed S; Mohammadi Moosa
Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members.
Molecular and cellular biology 2007;27(9):3417-28.
2007: Xue Yu; Moore Linda B; Orans Jillian; Peng Li; Bencharit Sompop; Kliewer Steven A; Redinbo Matthew R
Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition.
Molecular endocrinology (Baltimore, Md.) 2007;21(5):1028-38.
2006: Moore David D; Kato Shigeaki; Xie Wen; Mangelsdorf David J; Schmidt Daniel R; Xiao Rui; Kliewer Steven A
International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor.
Pharmacological reviews 2006;58(4):742-59.
2006: Choi Mihwa; Moschetta Antonio; Bookout Angie L; Peng Li; Umetani Michihisa; Holmstrom Sam R; Suino-Powell Kelly; Xu H Eric; Richardson James A; Gerard Robert D; Mangelsdorf David J; Kliewer Steven A
Identification of a hormonal basis for gallbladder filling.
Nature medicine 2006;12(11):1253-5.
2006: Inagaki Takeshi; Moschetta Antonio; Lee Youn-Kyoung; Peng Li; Zhao Guixiang; Downes Michael; Yu Ruth T; Shelton John M; Richardson James A; Repa Joyce J; Mangelsdorf David J; Kliewer Steven A
Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(10):3920-5.
2005: Inagaki Takeshi; Choi Mihwa; Moschetta Antonio; Peng Li; Cummins Carolyn L; McDonald Jeffrey G; Luo Guizhen; Jones Stacey A; Goodwin Bryan; Richardson James A; Gerard Robert D; Repa Joyce J; Mangelsdorf David J; Kliewer Steven A
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.
Cell metabolism 2005;2(4):217-25.
2005: Moschetta Antonio; Kliewer Steven A
Weaving betaKlotho into bile acid metabolism.
The Journal of clinical investigation 2005;115(8):2075-7.
2005: Li Yong; Choi Mihwa; Suino Kelly; Kovach Amanda; Daugherty Jennifer; Kliewer Steven A; Xu H Eric
Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(27):9505-10.
2005: Gu Peili; Goodwin Bryan; Chung Arthur C-K; Xu Xueping; Wheeler David A; Price Roger R; Galardi Cristin; Peng Li; Latour Anne M; Koller Beverly H; Gossen Jan; Kliewer Steven A; Cooney Austin J
Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development.
Molecular and cellular biology 2005;25(9):3492-505.
2005: Chrencik Jill E; Orans Jillian; Moore Linda B; Xue Yu; Peng Li; Collins Jon L; Wisely G Bruce; Lambert Millard H; Kliewer Steven A; Redinbo Matthew R
Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin.
Molecular endocrinology (Baltimore, Md.) 2005;19(5):1125-34.
2005: Li Yong; Choi Mihwa; Cavey Greg; Daugherty Jennifer; Suino Kelly; Kovach Amanda; Bingham Nathan C; Kliewer Steven A; Xu H Eric
Crystallographic identification and functional characterization of phospholipids as ligands for the orphan nuclear receptor steroidogenic factor-1.
Molecular cell 2005;17(4):491-502.
2005: Kliewer Steven A
Cholesterol detoxification by the nuclear pregnane X receptor.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(8):2675-6.
2005: Kliewer Steven A
Pregnane X receptor: predicting and preventing drug interactions.
Thrombosis research 2005;117(1-2):133-6; discussion 145-51.
2004: Suino Kelly; Peng Li; Reynolds Ross; Li Yong; Cha Ji-Young; Repa Joyce J; Kliewer Steven A; Xu H Eric
The nuclear xenobiotic receptor CAR: structural determinants of constitutive activation and heterodimerization.
Molecular cell 2004;16(6):893-905.
2003: Liu Yaping; Binz Jane; Numerick Mary Jo; Dennis Steve; Luo Guizhen; Desai Bhasha; MacKenzie Kathleen I; Mansfield Traci A; Kliewer Steven A; Goodwin Bryan; Jones Stacey A
Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis.
The Journal of clinical investigation 2003;112(11):1678-87.
2003: Kliewer Steven A
Anthrax mounts a nuclear attack on glucocorticoid signaling.
Trends in pharmacological sciences 2003;24(11):558-9.
2003: Kliewer Steven A
The nuclear pregnane X receptor regulates xenobiotic detoxification.
The Journal of nutrition 2003;133(7 Suppl):2444S-2447S.
2003: Holt Jason A; Luo Guizhen; Billin Andrew N; Bisi John; McNeill Y Yvette; Kozarsky Karen F; Donahee Mary; Wang Da Yuan; Mansfield Traci A; Kliewer Steven A; Goodwin Bryan; Jones Stacey A
Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis.
Genes & development 2003;17(13):1581-91.
2003: Tippin Timothy K; Hamilton Geraldine; Moore Linda; Beaudet Elizabeth J; Jolley Summer; Brodie Thomas A; Andrews Robert C; Becherer J David; McDougald Darryl L; Gaul Michael D; Hoivik Debie J; Mellon-Kusibab Kathy; Lehmann Jurgen; Kliewer Steven; Novick Steven; Laethem Ron; Zhao Zhiyang; LeCluyse Edward L
CYP3A induction by N-hydroxyformamide tumor necrosis factor-alpha converting enzyme/matrix metalloproteinase inhibitors use of a pregname X receptor activation assay and primary hepatocyte culture for assessing induction potential in humans.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(7):870-7.
2003: Maglich Jodi M; Parks Derek J; Moore Linda B; Collins Jon L; Goodwin Bryan; Billin Andrew N; Stoltz Catherine A; Kliewer Steven A; Lambert Millard H; Willson Timothy M; Moore John T
Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.
The Journal of biological chemistry 2003;278(19):17277-83.
2003: Goodwin Bryan; Watson Michael A; Kim Hwajin; Miao Ji; Kemper Jongsook Kim; Kliewer Steven A
Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-alpha.
Molecular endocrinology (Baltimore, Md.) 2003;17(3):386-94.
2003: Watkins Ryan E; Maglich Jodi M; Moore Linda B; Wisely G Bruce; Noble Schroeder M; Davis-Searles Paula R; Lambert Mill H; Kliewer Steven A; Redinbo Matthew R
2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin.
Biochemistry 2003;42(6):1430-8.
2003: Moore John T; Moore Linda B; Maglich Jodi M; Kliewer Steve A
Functional and structural comparison of PXR and CAR.
Biochimica et biophysica acta 2003;1619(3):235-8.
2003: Goodwin Bryan; Gauthier Karine C; Umetani Michihisa; Watson Michael A; Lochansky Matthew I; Collins Jon L; Leitersdorf Eran; Mangelsdorf David J; Kliewer Steven A; Repa Joyce J
Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(1):223-8.
2002: Kliewer Steven A; Goodwin Bryan; Willson Timothy M
The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism.
Endocrine reviews 2002;23(5):687-702.
2002: Maglich Jodi M; Stoltz Catherine M; Goodwin Bryan; Hawkins-Brown Diane; Moore John T; Kliewer Steven A
Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification.
Molecular pharmacology 2002;62(3):638-46.
2002: Whitney Karl D; Watson Michael A; Collins Jon L; Benson William G; Stone Tammy M; Numerick Mary Jo; Tippin Timothy K; Wilson Joan G; Winegar Deborah A; Kliewer Steven A
Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system.
Molecular endocrinology (Baltimore, Md.) 2002;16(6):1378-85.
2002: Goodwin Bryan; Kliewer Steven A
Nuclear receptors. I. Nuclear receptors and bile acid homeostasis.
American journal of physiology. Gastrointestinal and liver physiology 2002;282(6):G926-31.
2002: Collins Jon L; Fivush Adam M; Watson Michael A; Galardi Cristin M; Lewis Michael C; Moore Linda B; Parks Derek J; Wilson Joan G; Tippin Tim K; Binz Jane G; Plunket Kelli D; Morgan Daniel G; Beaudet Elizabeth J; Whitney Karl D; Kliewer Steven A; Willson Timothy M
Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines.
Journal of medicinal chemistry 2002;45(10):1963-6.
2002: Moore Linda B; Maglich Jodi M; McKee David D; Wisely Bruce; Willson Timothy M; Kliewer Steven A; Lambert Millard H; Moore John T
Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors.
Molecular endocrinology (Baltimore, Md.) 2002;16(5):977-86.
2002: Muoio Deborah M; Way James M; Tanner Charles J; Winegar Deborah A; Kliewer Steven A; Houmard Joseph A; Kraus William E; Dohm G Lynis
Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells.
Diabetes 2002;51(4):901-9.
2002: Kliewer Steven A; Willson Timothy M
Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor.
Journal of lipid research 2002;43(3):359-64.
2002: Xu H Eric; Stanley Thomas B; Montana Valerie G; Lambert Millard H; Shearer Barry G; Cobb Jeffery E; McKee David D; Galardi Cristin M; Plunket Kelli D; Nolte Robert T; Parks Derek J; Moore John T; Kliewer Steven A; Willson Timothy M; Stimmel Julie B
Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha.
Nature 2002;415(6873):813-7.
2002: Kast Heidi R; Goodwin Bryan; Tarr Paul T; Jones Stacey A; Anisfeld Andrew M; Stoltz Catherine M; Tontonoz Peter; Kliewer Steve; Willson Timothy M; Edwards Peter A
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor.
The Journal of biological chemistry 2002;277(4):2908-15.
2002: Moore John T; Goodwin Bryan; Willson Timothy M; Kliewer Steven A
Nuclear receptor regulation of genes involved in bile acid metabolism.
Critical reviews in eukaryotic gene expression 2002;12(2):119-35.
2002: Jones Stacey A; Moore Linda B; Wisely G Bruce; Kliewer Steven A
Use of in vitro pregnane X receptor assays to assess CYP3A4 induction potential of drug candidates.
Methods in enzymology 2002;357():161-70.
2001: Xu H E; Lambert M H; Montana V G; Plunket K D; Moore L B; Collins J L; Oplinger J A; Kliewer S A; Gampe R T; McKee D D; Moore J T; Willson T M
Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13919-24.
2001: Willson T M; Jones S A; Moore J T; Kliewer S A
Chemical genomics: functional analysis of orphan nuclear receptors in the regulation of bile acid metabolism.
Medicinal research reviews 2001;21(6):513-22.
2001: Whitney K D; Watson M A; Goodwin B; Galardi C M; Maglich J M; Wilson J G; Willson T M; Collins J L; Kliewer S A
Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages.
The Journal of biological chemistry 2001;276(47):43509-15.
2001: Winegar D A; Brown P J; Wilkison W O; Lewis M C; Ott R J; Tong W Q; Brown H R; Lehmann J M; Kliewer S A; Plunket K D; Way J M; Bodkin N L; Hansen B C
Effects of fenofibrate on lipid parameters in obese rhesus monkeys.
Journal of lipid research 2001;42(10):1543-51.
2001: Goodwin B; Moore L B; Stoltz C M; McKee D D; Kliewer S A
Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor.
Molecular pharmacology 2001;60(3):427-31.
2001: Way J M; Görgün C Z; Tong Q; Uysal K T; Brown K K; Harrington W W; Oliver W R; Willson T M; Kliewer S A; Hotamisligil G S
Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists.
The Journal of biological chemistry 2001;276(28):25651-3.
2001: Watkins R E; Wisely G B; Moore L B; Collins J L; Lambert M H; Williams S P; Willson T M; Kliewer S A; Redinbo M R
The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity.
Science (New York, N.Y.) 2001;292(5525):2329-33.
2001: Oliver W R; Shenk J L; Snaith M R; Russell C S; Plunket K D; Bodkin N L; Lewis M C; Winegar D A; Sznaidman M L; Lambert M H; Xu H E; Sternbach D D; Kliewer S A; Hansen B C; Willson T M
A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(9):5306-11.
2001: Staudinger J L; Goodwin B; Jones S A; Hawkins-Brown D; MacKenzie K I; LaTour A; Liu Y; Klaassen C D; Brown K K; Reinhard J; Willson T M; Koller B H; Kliewer S A
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3369-74.
2001: Way J M; Harrington W W; Brown K K; Gottschalk W K; Sundseth S S; Mansfield T A; Ramachandran R K; Willson T M; Kliewer S A
Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor gamma activation has coordinate effects on gene expression in multiple insulin-sensitive tissues.
Endocrinology 2001;142(3):1269-77.
2001: Kliewer S A; Xu H E; Lambert M H; Willson T M
Peroxisome proliferator-activated receptors: from genes to physiology.
Recent progress in hormone research 2001;56():239-63.
2000: Moore J T; Kliewer S A
Use of the nuclear receptor PXR to predict drug interactions.
Toxicology 2000;153(1-3):1-10.
2000: Goodwin B; Jones S A; Price R R; Watson M A; McKee D D; Moore L B; Galardi C; Wilson J G; Lewis M C; Roth M E; Maloney P R; Willson T M; Kliewer S A
A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis.
Molecular cell 2000;6(3):517-26.
2000: Moore L B; Goodwin B; Jones S A; Wisely G B; Serabjit-Singh C J; Willson T M; Collins J L; Kliewer S A
St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(13):7500-2.
2000: Takada I; Yu R T; Xu H E; Lambert M H; Montana V G; Kliewer S A; Evans R M; Umesono K
Alteration of a single amino acid in peroxisome proliferator-activated receptor-alpha (PPAR alpha) generates a PPAR delta phenotype.
Molecular endocrinology (Baltimore, Md.) 2000;14(5):733-40.
2000: Moore L B; Parks D J; Jones S A; Bledsoe R K; Consler T G; Stimmel J B; Goodwin B; Liddle C; Blanchard S G; Willson T M; Collins J L; Kliewer S A
Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands.
The Journal of biological chemistry 2000;275(20):15122-7.
2000: Gampe R T; Montana V G; Lambert M H; Miller A B; Bledsoe R K; Milburn M V; Kliewer S A; Willson T M; Xu H E
Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors.
Molecular cell 2000;5(3):545-55.
2000: Jones S A; Moore L B; Shenk J L; Wisely G B; Hamilton G A; McKee D D; Tomkinson N C; LeCluyse E L; Lambert M H; Willson T M; Kliewer S A; Moore J T
The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution.
Molecular endocrinology (Baltimore, Md.) 2000;14(1):27-39.
1999: Brown P J; Winegar D A; Plunket K D; Moore L B; Lewis M C; Wilson J G; Sundseth S S; Koble C S; Wu Z; Chapman J M; Lehmann J M; Kliewer S A; Willson T M
A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity.
Journal of medicinal chemistry 1999;42(19):3785-8.
1999: Brown K K; Henke B R; Blanchard S G; Cobb J E; Mook R; Kaldor I; Kliewer S A; Lehmann J M; Lenhard J M; Harrington W W; Novak P J; Faison W; Binz J G; Hashim M A; Oliver W O; Brown H R; Parks D J; Plunket K D; Tong W Q; Menius J A; Adkison K; Noble S A; Willson T M
A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat.
Diabetes 1999;48(7):1415-24.
1999: Oberfield J L; Collins J L; Holmes C P; Goreham D M; Cooper J P; Cobb J E; Lenhard J M; Hull-Ryde E A; Mohr C P; Blanchard S G; Parks D J; Moore L B; Lehmann J M; Plunket K; Miller A B; Milburn M V; Kliewer S A; Willson T M
A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(11):6102-6.
1999: Parks D J; Blanchard S G; Bledsoe R K; Chandra G; Consler T G; Kliewer S A; Stimmel J B; Willson T M; Zavacki A M; Moore D D; Lehmann J M
Bile acids: natural ligands for an orphan nuclear receptor.
Science (New York, N.Y.) 1999;284(5418):1365-8.
1999: Kliewer S A; Lehmann J M; Willson T M
Orphan nuclear receptors: shifting endocrinology into reverse.
Science (New York, N.Y.) 1999;284(5415):757-60.
1999: Xu H E; Lambert M H; Montana V G; Parks D J; Blanchard S G; Brown P J; Sternbach D D; Lehmann J M; Wisely G B; Willson T M; Kliewer S A; Milburn M V
Molecular recognition of fatty acids by peroxisome proliferator-activated receptors.
Molecular cell 1999;3(3):397-403.
1999: Janowski B A; Grogan M J; Jones S A; Wisely G B; Kliewer S A; Corey E J; Mangelsdorf D J
Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(1):266-71.
1999: Kliewer S A; Lehmann J M; Milburn M V; Willson T M
The PPARs and PXRs: nuclear xenobiotic receptors that define novel hormone signaling pathways.
Recent progress in hormone research 1999;54():345-67; discussion 367-8.
1998: Henke B R; Blanchard S G; Brackeen M F; Brown K K; Cobb J E; Collins J L; Harrington W W; Hashim M A; Hull-Ryde E A; Kaldor I; Kliewer S A; Lake D H; Leesnitzer L M; Lehmann J M; Lenhard J M; Orband-Miller L A; Miller J F; Mook R A; Noble S A; Oliver W; Parks D J; Plunket K D; Szewczyk J R; Willson T M
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents.
Journal of medicinal chemistry 1998;41(25):5020-36.
1998: Kliewer S A; Willson T M
The nuclear receptor PPARgamma - bigger than fat.
Current opinion in genetics & development 1998;8(5):576-81.
1998: Lehmann J M; McKee D D; Watson M A; Willson T M; Moore J T; Kliewer S A
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.
The Journal of clinical investigation 1998;102(5):1016-23.
1998: Moore J T; McKee D D; Slentz-Kesler K; Moore L B; Jones S A; Horne E L; Su J L; Kliewer S A; Lehmann J M; Willson T M
Cloning and characterization of human estrogen receptor beta isoforms.
Biochemical and biophysical research communications 1998;247(1):75-8.
1998: Kliewer S A; Moore J T; Wade L; Staudinger J L; Watson M A; Jones S A; McKee D D; Oliver B B; Willson T M; Zetterström R H; Perlmann T; Lehmann J M
An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway.
Cell 1998;92(1):73-82.
1997: Brown P J; Smith-Oliver T A; Charifson P S; Tomkinson N C; Fivush A M; Sternbach D D; Wade L E; Orband-Miller L; Parks D J; Blanchard S G; Kliewer S A; Lehmann J M; Willson T M
Identification of peroxisome proliferator-activated receptor ligands from a biased chemical library.
Chemistry & biology 1997;4(12):909-18.
1997: Lenhard J M; Kliewer S A; Paulik M A; Plunket K D; Lehmann J M; Weiel J E
Effects of troglitazone and metformin on glucose and lipid metabolism: alterations of two distinct molecular pathways.
Biochemical pharmacology 1997;54(7):801-8.
1997: Zavacki A M; Lehmann J M; Seol W; Willson T M; Kliewer S A; Moore D D
Activation of the orphan receptor RIP14 by retinoids.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(15):7909-14.
1997: Kliewer S A; Sundseth S S; Jones S A; Brown P J; Wisely G B; Koble C S; Devchand P; Wahli W; Willson T M; Lenhard J M; Lehmann J M
Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(9):4318-23.
1997: Lehmann J M; Lenhard J M; Oliver B B; Ringold G M; Kliewer S A
Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs.
The Journal of biological chemistry 1997;272(6):3406-10.
1997: Lehmann J M; Kliewer S A; Moore L B; Smith-Oliver T A; Oliver B B; Su J L; Sundseth S S; Winegar D A; Blanchard D E; Spencer T A; Willson T M
Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway.
The Journal of biological chemistry 1997;272(6):3137-40.
1996: Willson T M; Lehmann J M; Kliewer S A
Discovery of ligands for the nuclear peroxisome proliferator-activated receptors.
Annals of the New York Academy of Sciences 1996;804():276-83.
1996: Tai T A; Jennermann C; Brown K K; Oliver B B; MacGinnitie M A; Wilkison W O; Brown H R; Lehmann J M; Kliewer S A; Morris D C; Graves R A
Activation of the nuclear receptor peroxisome proliferator-activated receptor gamma promotes brown adipocyte differentiation.
The Journal of biological chemistry 1996;271(47):29909-14.
1996: Gimble J M; Robinson C E; Wu X; Kelly K A; Rodriguez B R; Kliewer S A; Lehmann J M; Morris D C
Peroxisome proliferator-activated receptor-gamma activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells.
Molecular pharmacology 1996;50(5):1087-94.
1996: Willson T M; Cobb J E; Cowan D J; Wiethe R W; Correa I D; Prakash S R; Beck K D; Moore L B; Kliewer S A; Lehmann J M
The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones.
Journal of medicinal chemistry 1996;39(3):665-8.
1995: Kliewer S A; Lenhard J M; Willson T M; Patel I; Morris D C; Lehmann J M
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation.
Cell 1995;83(5):813-9.
1995: Lehmann J M; Moore L B; Smith-Oliver T A; Wilkison W O; Willson T M; Kliewer S A
An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma).
The Journal of biological chemistry 1995;270(22):12953-6.
1994: Lee M S; Sem D S; Kliewer S A; Provencal J; Evans R M; Wright P E
NMR assignments and secondary structure of the retinoid X receptor alpha DNA-binding domain. Evidence for the novel C-terminal helix.
European journal of biochemistry / FEBS 1994;224(2):639-50.
1994: Forman B M; Chen J; Blumberg B; Kliewer S A; Henshaw R; Ong E S; Evans R M
Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors.
Molecular endocrinology (Baltimore, Md.) 1994;8(9):1253-61.
1994: Kliewer S A; Forman B M; Blumberg B; Ong E S; Borgmeyer U; Mangelsdorf D J; Umesono K; Evans R M
Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(15):7355-9.
1993: Lee M S; Kliewer S A; Provencal J; Wright P E; Evans R M
Structure of the retinoid X receptor alpha DNA binding domain: a helix required for homodimeric DNA binding.
Science (New York, N.Y.) 1993;260(5111):1117-21.
1993: Mangelsdorf D J; Kliewer S A; Kakizuka A; Umesono K; Evans R M
Retinoid receptors.
Recent progress in hormone research 1993;48():99-121.
1992: Kliewer S A; Umesono K; Noonan D J; Heyman R A; Evans R M
Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors.
Nature 1992;358(6389):771-4.
1992: Ghazal P; DeMattei C; Giulietti E; Kliewer S A; Umesono K; Evans R M
Retinoic acid receptors initiate induction of the cytomegalovirus enhancer in embryonal cells.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7630-4.
1992: Kliewer S A; Umesono K; Heyman R A; Mangelsdorf D J; Dyck J A; Evans R M
Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(4):1448-52.
1992: Kliewer S A; Umesono K; Mangelsdorf D J; Evans R M
Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling.
Nature 1992;355(6359):446-9.
1991: Mangelsdorf D J; Umesono K; Kliewer S A; Borgmeyer U; Ong E S; Evans R M
A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR.
Cell 1991;66(3):555-61.
1991: Schüle R; Rangarajan P; Yang N; Kliewer S; Ransone L J; Bolado J; Verma I M; Evans R M
Retinoic acid is a negative regulator of AP-1-responsive genes.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(14):6092-6.
1990: Schüle R; Rangarajan P; Kliewer S; Ransone L J; Bolado J; Yang N; Verma I M; Evans R M
Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor.
Cell 1990;62(6):1217-26.

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