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Wolfgang Klinger

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Amelie Lupp; Elke Karge; Manfred Danz; Thomas Deufel; Herbert Oelschläger; Wolfgang Klinger
Single and chronic administration of ciprofibrate or of ciprofibrate-glycinate in male Fischer 344 rats: comparison of the effects on morphological and biochemical parameters in liver and blood.
Wolfgang Klinger
Developmental pharmacology and toxicology: biotransformation of drugs and other xenobiotics during postnatal development.
Wolfgang Klinger; Amelie Lupp; Elke Karge; H Baumbach; F Eichhorn; A Feix; F Füldner; S Gernhardt; Lilla Knels; B Kost; G Mertens; F Werner; Michael Oettel; W Römer; S Schwarz; Walter Elger; Birgitt Schneider
Estradiol, testosterone, dehydroepiandrosterone and androstenedione: novel derivatives and enantiomers. Interactions with rat liver microsomal cytochrome P450 and antioxidant/radical scavenger activities in vitro.

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All Publications

2005: Amelie Lupp; Elke Karge; Manfred Danz; Thomas Deufel; Herbert Oelschläger; Wolfgang Klinger
Single and chronic administration of ciprofibrate or of ciprofibrate-glycinate in male Fischer 344 rats: comparison of the effects on morphological and biochemical parameters in liver and blood.
European journal of drug metabolism and pharmacokinetics 2005;30(3):203-18.
2005: Wolfgang Klinger
Developmental pharmacology and toxicology: biotransformation of drugs and other xenobiotics during postnatal development.
European journal of drug metabolism and pharmacokinetics 2005;30(1-2):3-17.
2002: Wolfgang Klinger; Amelie Lupp; Elke Karge; H Baumbach; F Eichhorn; A Feix; F Füldner; S Gernhardt; Lilla Knels; B Kost; G Mertens; F Werner; Michael Oettel; W Römer; S Schwarz; Walter Elger; Birgitt Schneider
Estradiol, testosterone, dehydroepiandrosterone and androstenedione: novel derivatives and enantiomers. Interactions with rat liver microsomal cytochrome P450 and antioxidant/radical scavenger activities in vitro.
Toxicology letters 2002;128(1-3):129-44.
2002: Amelie Lupp; Manfred Danz; Dieter Müller; Wolfgang Klinger
Expression and inducibility of cytochrome P450 isoforms in 1-year-old intrasplenic liver cell transplants in rats.
Transplant international : official journal of the European Society for Organ Transplantation 2002;15(2-3):96-107.
2001: Amelie Lupp; Manuela Tralls; Udo Fuchs; Wolfgang Klinger
Transplantation of fetal liver tissue suspension into the spleens of adult syngenic rats: effects of different cytotoxins on cytochrome P450 mediated monooxygenase functions and on oxidative state.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2001;52(6):529-38.
2001: Wolfgang Klinger; Amelie Lupp; Astrid Barth; Elke Karge; Lilla Knels; Urs Dieter Kuhn; Dieter Müller; F Schiller; U Demme; Pirjo Lindström-Seppä; O Hänninen
Cytochrome P450 (P450) isoforms expression, P450 concentration, monooxygenase activities, reactive oxygen species formation, lipid peroxidation, and glutathione content in wild catch carp and tench liver--influence of a two weeks exposure to phenobarbital.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2001;52(6):513-22.
2001: Wolfgang Klinger; Elke Karge; U Demme; M Kretzschmar
Interactions of melatonin with the liver microsomal cytochrome P450 system of rats and humans in vitro and effects on the P450 system and the antioxidative status in rat liver after acute treatment.
European journal of drug metabolism and pharmacokinetics 2001;26(1-2):31-5.
2000: Amelie Lupp; Norma Lucas; Manfred Danz; Wolfgang Klinger
Transplantation of fetal liver tissue suspension into the spleens of adult syngenic rats: effects of different cytotoxins on cytochrome P450 isoforms expression and on glycogen content.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2000;52(5):381-93.
2000: Astrid Barth; Dieter Müller; Elke Karge; Wolfgang Klinger
Influence of subchronic administration of catechol estrogens on the formation of reactive oxygen species in rat liver microsomes.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2000;52(4):323-8.
1999: Amelie Lupp; Manuela Tralls; Udo Fuchs; Norma Lucas; Manfred Danz; Wolfgang Klinger
Transplantation of fetal liver tissue suspension into the spleens of adult syngenic rats: effects of various mitogens and cytotoxins on cytochrome P450 (P450) isoforms expression and on P450 mediated monooxygenase functions.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1999;51(4-5):375-88.
1999: Astrid Barth; G Landmann; K Liepold; H Zapf; Dieter Müller; Elke Karge; Wolfgang Klinger
Influence of oestrogens on formation of reactive oxygen species in liver microsomes of differently aged male Wistar rats.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1999;51(4-5):282-8.
1999: Wolfgang Klinger; Herbert Oelschläger; D Rothley; Elke Karge; Andreas Seeling
Interaction of chlormezanone enantiomers with rat liver microsomes.
European journal of drug metabolism and pharmacokinetics 1999;24(1):63-8.
1999: Amelie Lupp; K Lau; A K Trautmann; T Krausse; Wolfgang Klinger
Transplantation of fetal liver tissue suspension into the spleens of adult syngenic rats: inducibility of cytochrome P450 dependent monooxygenase functions by beta-naphthoflavone, phenobarbital and dexamethasone.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1999;51(1):65-74.
1998: Michael Rost; Elke Karge; Wolfgang Klinger
What do we measure with luminol-, lucigenin- and penicillin-amplified chemiluminescence? 1. Investigations with hydrogen peroxide and sodium hypochlorite.
Journal of bioluminescence and chemiluminescence 1998;13(6):355-63.
1998: Amelie Lupp; S Kerst; Elke Karge; G Quack; Wolfgang Klinger
Investigation on possible antioxidative properties of the NMDA-receptor antagonists ketamine, memantine, and amantadine in comparison to nicanartine in vitro.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1998;50(4-6):501-6.
1998: Astrid Barth; Reinhard Bauer; Tomas Gedrange; Bernd Walter; Wolfgang Klinger; Ulrich Zwiener
Influence of hypoxia and hypoxia/hypercapnia upon brain and blood peroxidative and glutathione status in normal weight and growth-restricted newborn piglets.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1998;50(4-6):402-10.
1998: Herbert Oelschläger; D Rothley; Wolfgang Klinger; Elke Karge; Heinz Vogelsang
Chromatographic resolution of ciprofibrate and interaction of the racemate and both enantiomers with rat liver microsomes in vitro.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1998;50(4-6):323-9.
1998: Wolfgang Klinger; Amelie Lupp; Elke Karge; Herbert Oelschläger; D Rothley; Manfred Danz; Werner Linss; S Löbel; Thomas Deufel; M Müller; M Klinger; W Kühnel
Ciprofibrate--racemate and enantiomers: effects of a four-week treatment on male inbred Fischer rats. A biochemical and morphological study.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1998;50(4-6):301-14.
1998: Herbert Oelschläger; Wolfgang Klinger; D Rothley; Andreas Seeling; H Bockhard; B Hofmann; Heike Machts; H Riederer; H Rackur
[Cleavage and biotransformation of the central muscle relaxant chlormezanone].
Die Pharmazie 1998;53(9):620-4.
1998: Michael Rost; Elke Karge; Wolfgang Klinger
Luminol and lucigenin amplified chemiluminescence and lipidperoxidation with brain microsomes from rats during ontogenetic development.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1998;50(3):253-5.
1998: Amelie Lupp; A K Trautmann; T Krausse; Wolfgang Klinger
Developmental changes of cytochrome P450 dependent monooxygenase functions after transplantation of fetal liver tissue suspension into spleens of adult syngenic rats.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1998;50(3):239-44.
1998: Amelie Lupp; Norma Lucas; P Lindström-Seppa; K Koponen; O Hänninen; Manfred Danz; Wolfgang Klinger
Transplantation of fetal liver tissue suspension into the spleens of adult syngenic rats: effects of beta-naphthoflavone, phenobarbital and dexamethasone on cytochrome P450 isoforms expression and on glycogen storage.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1998;50(3):173-83.
1998: Amelie Lupp; Norma Lucas; Pirjo Lindström-Seppä; K Koponen; O Hänninen; Manfred Danz; Wolfgang Klinger
Developmental expression of cytochrome P450 isoforms after transplantation of fetal liver tissue suspension into the spleens of adult syngenic rats.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1998;50(1):41-51.
1998: Astrid Barth; Reinhard Bauer; Tomas Gedrange; Bernd Walter; C Linss; Wolfgang Klinger
Influence of hypoxia and hyperthermia upon peroxidative and glutathione status in growth-restricted newborn piglets.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1998;50(1):31-3.
1998: Amelie Lupp; F Hessler; T Philipp; Manfred Danz; Wolfgang Klinger
Influence of different transplantation methods on liver cell survival in spleens of rats.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1998;50(1):1-8.
1997: S Gernhardt; Elke Karge; Bruno Schönecker; Wolfgang Klinger
Influence of various estrogens on biotransformation: affinity to cytochrome P-450, structure activity relationships, and scavenger function.
Archiv der Pharmazie 1997;330(5):135-40.
1997: Wolfgang Klinger; Herbert Oelschläger; Elke Karge; D Rothley
Interaction of chlormezanone with rat liver microsomes and its degradation.
European journal of drug metabolism and pharmacokinetics 1997;22(2):165-71.
1996: Wolfgang Klinger; Elke Karge; M Kretzschmar; Michael Rost; H P Schulze; R Dargel; C Reinemann; H Rein
Luminol-and lucigenin-amplified chemiluminescence with rat liver microsomes. Kinetics and influence of ascorbic acid, glutathione, dimethylsulfoxide, N-t-butyl-a-phenyl-nitrone, copper-ions and a copper complex, catalase, superoxide dismutase, hexobarbital and aniline.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1996;48(5):447-60.
1996: Astrid Barth; Christian Fleck; Wolfgang Klinger
Development of organic anion transport in the liver.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1996;48(5):421-32.
1995: Wolfgang Klinger; Elke Karge
Influence of skin and muscle lesions on the hepatic cytochrome P450 function in 10 and 60 day-old male Wistar rats.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1995;47(4):309-12.
1995: Wolfgang Klinger; Elke Karge; Manfred Danz; M Krug
Nerval influences on liver cytochrome P450.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1995;47(4):299-304.
1995: Astrid Barth; Reinhard Bauer; H Kluge; Tomas Gedrange; Bernd Walter; Wolfgang Klinger; Ulrich Zwiener
Brain peroxidative and glutathione status after moderate hypoxia in normal weight and intra-uterine growth-restricted newborn piglets.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1995;47(2-3):139-47.
1994: Astrid Barth; Reinhard Bauer; Wolfgang Klinger; Ulrich Zwiener
Peroxidative status and glutathione content of the brain in normal weight and intra-uterine growth-retarded newborn piglets.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1994;45(8):519-24.
1993: F Jahn; A Reuter; Elke Karge; Manfred Danz; Wolfgang Klinger
Age dependent different influence of carbon tetrachloride on biotransformation of xenobiotics, glutathione content, lipid peroxidation and histopathology of rat liver.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1993;45(2-3):101-7.
1992: A Reuter; Wolfgang Klinger
The influence of systemic hypoxia and reoxygenation on the glutathione redox system of brain, liver, lung and plasma in newborn rats.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1992;44(6):339-43.
1992: M Kretzschmar; D Reinhardt; J Schlechtweg; G Machnik; Wolfgang Klinger; W Schirrmeister
Glutathione homeostasis in rats chronically treated with ethanol. Evidence for an increased hepatic GSH export in vivo.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1992;44(6):344-8.
1992: M Kretzschmar; U Pfeifer; G Machnik; Wolfgang Klinger
Glutathione homeostasis and turnover in the totally hepatectomized rat: evidence for a high glutathione export capacity of extrahepatic tissues.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1992;44(5):273-81.
1991: Wolfgang Klinger; Dieter Müller; U Kleeberg; M Kretzschmar; F K Splinter
The influence of "essential" phospholipids (EPL) on phase-I- and phase-II-reactions and on the glutathione status in the liver of aging rats.
Experimental pathology 1991;41(3):151-6.
1991: F Jahn; Elke Karge; Wolfgang Klinger
Influence of neonatal and postnatal administration of diethylstilbestrol on hepatic monooxygenase activities and lipid peroxidation in adult rats.
Journal of experimental animal science 1991;34(5-6):218-24.
1991: M Kretzschmar; H Franke; G Machnik; T Zimmermann; R Dargel; Wolfgang Klinger
The glutathione system in rat liver chronically injured by thioacetamide.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1991;14():68-70.
1991: M Kretzschmar; G Bach; I Ratzmann; C Fleck; Wolfgang Klinger
Ontogenetic changes in hepatic glutathione system (synthesis, catabolism, export) of male Uje:WIST rats.
Journal of experimental animal science 1991;34(4):132-9.
1991: T Wagner; M Kretzschmar; Wolfgang Klinger; W Zenk
[The effect of hadacidin, ultraviolet irradiation of blood (UVB) and thiamine on the prenatal development of Uje:WIST rats: correlation with the hepatic activity of gamma-glutamyltranspeptidase (GGT)].
Journal of experimental animal science 1991;34(5-6):198-202.
1991: M Kretzschmar; G Machnik; D Oesterle; T Zimmermann; Wolfgang Klinger
Gamma-glutamyltranspeptidase (GGT) in experimental liver cirrhosis induced by thioacetamide: a biochemical and enzymehistochemical study.
Experimental pathology 1991;43(3-4):195-203.
1991: M Kretzschmar; G Machnik; Andreas Müller; F K Splinter; T Zimmermann; Wolfgang Klinger
Experimental treatment of thioacetamide-induced liver cirrhosis by metenolone acetate. A morphological and biochemical study.
Experimental pathology 1991;42(1):37-46.
1990: F Jahn; Elke Karge; Wolfgang Klinger
Influence of age, phenobarbital and beta-naphthoflavone on hepatic microsomal lipid peroxidation in rats.
Zeitschrift für Versuchstierkunde 1990;33(3):140-5.
1990: M Kretzschmar; Wolfgang Klinger
The hepatic glutathione system--influences of xenobiotics.
Experimental pathology 1990;38(3):145-64.
1990: M Kretzschmar; Reinhild Glöckner; Wolfgang Klinger
Glutathione levels in liver and brain of newborn rats: investigations of the influence of hypoxia and reoxidation on lipid peroxidation.
Physiologia Bohemoslovaca 1990;39(3):257-60.
1989: F Jahn; M Kadiiska; E Serbinova; Wolfgang Klinger; T Stoytchev
The influence of acute phenytoin administration on biotransformation and lipid peroxidation in the liver of rats of different ages.
Biochemical pharmacology 1989;38(22):4148-51.
1989: Wolfgang Klinger; R Hirschelmann; J Süss
Birch sap and birch leaves extract: screening for antimicrobial, phagocytosis-influencing, antiphlogistic and antipyretic activity.
Die Pharmazie 1989;44(8):558-60.
1989: F Jahn; Wolfgang Klinger
Influence of prenatal administration of cadmium on postnatal development and inducibility of hepatic monooxygenases in rats.
Pharmacology & toxicology 1989;64(3):291-2.
1989: Dieter Müller; Wolfgang Klinger
Influence of glucocorticoids on the postnatal development of cytochrome P-450 in rat liver.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1989;13():343-6.
1989: M Kretzschmar; H Franke; T Zimmermann; R Dargel; Wolfgang Klinger
Glutathione synthesis and export in experimental liver cirrhosis induced by thioacetamide: relations to ultrastructural changes.
Experimental pathology 1989;36(2):113-22.
1988: L Kersten; H Bräunlich; Wolfgang Klinger
Testing of dioxolan-methyl-metaacrylate (DMA) for hepatotoxicity and nephrotoxicity.
Die Pharmazie 1988;43(10):711-4.
1988: Wolfgang Klinger; Theodora R Devereux; J R Fouts
Functional and structural zonal hepatocyte heterogeneity--dynamics and ontogenic development.
Experimental pathology 1988;35(2):69-91.
1986: Reinhild Glöckner; Wolfgang Klinger; Elke Karge
The development of hepatic biotransformation (ethylmorphine-N-demethylation and ethoxycoumarin-O-deethylation) and their inducibility by phenobarbital in male rats delivered prematurely by caesarean section.
Zeitschrift für Versuchstierkunde 1986;28(4):173-8.
1983: M Kadiiska; T Stoytchev; F Jahn; Wolfgang Klinger
Effect of cadmium in vitro on benzphetamine-N-demethylation and ethoxyresorufin-O-deethylation in rats of different age.
Acta physiologica et pharmacologica Bulgarica 1983;9(4):21-30.
1982: F Jahn; F Schiller; Wolfgang Klinger; Elke Karge
The influence of fasting on monooxygenase system in rat liver in relation to age.
Zeitschrift für Versuchstierkunde 1982;24(5-6):281-90.