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Judith Klinman

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Valerie J Klema; Judith P Klinman; Corinne J Solheid; Carrie M Wilmot
Structural analysis of aliphatic versus aromatic substrate specificity in a copper amine oxidase from Hansenula polymorpha.
Robert L Osborne; Hui Zhu; Ninian J Blackburn; Anthony T Iavarone; Judith P Klinman
Interdomain long-range electron transfer becomes rate-limiting in the Y216A variant of tyramine β-monooxygenase.
Robert L Osborne; Hui Zhu; Corinna R Hess; Anthony T Iavarone; Judith P Klinman
Inactivation of Met471Cys tyramine β-monooxygenase results from site-specific cysteic acid formation.

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All Publications

2013: Valerie J Klema; Judith P Klinman; Corinne J Solheid; Carrie M Wilmot
Structural analysis of aliphatic versus aromatic substrate specificity in a copper amine oxidase from Hansenula polymorpha.
Biochemistry 2013;52(13):2291-301.
2013: Robert L Osborne; Hui Zhu; Ninian J Blackburn; Anthony T Iavarone; Judith P Klinman
Interdomain long-range electron transfer becomes rate-limiting in the Y216A variant of tyramine β-monooxygenase.
Biochemistry 2013;52(7):1179-91.
2012: Robert L Osborne; Hui Zhu; Corinna R Hess; Anthony T Iavarone; Judith P Klinman
Inactivation of Met471Cys tyramine β-monooxygenase results from site-specific cysteic acid formation.
Biochemistry 2012;51(38):7488-95.
2012: Zachary D Nagel; Corey W Meadows; Brian J Bahnson; Ming Dong; Judith P Klinman
Active site hydrophobic residues impact hydrogen tunneling differently in a thermophilic alcohol dehydrogenase at optimal versus nonoptimal temperatures.
Biochemistry 2012;51(20):4147-56.
2012: Valerie J Klema; Judith P Klinman; Bryan J Johnson; Carrie M Wilmot
The precursor form of Hansenula polymorpha copper amine oxidase 1 in complex with CuI and CoII.
Acta crystallographica. Section F, Structural biology and crystallization communications 2012;68(Pt 5):501-10.
2012: Yao-Qing Shen; Kimmen Sjölander; Florence Bonnot; Erin M Imsand; Jordan M RoseFigura; Judith P Klinman
Distribution and properties of the genes encoding the biosynthesis of the bacterial cofactor, pyrroloquinoline quinone.
Biochemistry 2012;51(11):2265-75.
2011: Jianyu Zhang; Judith P Klinman
Enzymatic methyl transfer: role of an active site residue in generating active site compaction that correlates with catalytic efficiency.
Journal of the American Chemical Society 2011;133(43):17134-7.
2011: Olayinka A Oyeyemi; Katheryn A Resing; Kevin M Sours; Natalie G Ahn; Amnon Kohen; Thomas Lee; Judith P Klinman
Comparative hydrogen-deuterium exchange for a mesophilic vs thermophilic dihydrofolate reductase at 25 °C: identification of a single active site region with enhanced flexibility in the mesophilic protein.
Biochemistry 2011;50(38):8251-60.
2011: Zachary D Nagel; Brian J Bahnson; Ming Dong; Judith P Klinman
Impaired protein conformational landscapes as revealed in anomalous Arrhenius prefactors.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(26):10520-5.
2011: Jordan M RoseFigura; Sandra Puehringer; Robert Schwarzenbacher; Hirohide Toyama; Judith P Klinman
Characterization of a protein-generated O₂ binding pocket in PqqC, a cofactorless oxidase catalyzing the final step in PQQ production.
Biochemistry 2011;50(9):1556-66.
2011: Matthew P Meyer; Judith P Klinman
Investigating inner-sphere reorganization via secondary kinetic isotope effects in the C-H cleavage reaction catalyzed by soybean lipoxygenase: tunneling in the substrate backbone as well as the transferred hydrogen.
Journal of the American Chemical Society 2011;133(3):430-9.
2010: Zachary D Nagel; Judith P Klinman
Update 1 of: Tunneling and dynamics in enzymatic hydride transfer.
Chemical reviews 2010;110(12):PR41-67.
2010: Judith P Klinman
Enzyme dynamics: Control of active-site compression.
Nature chemistry 2010;2(11):907-9.
2010: Corinna R Hess; Judith P Klinman; Ninian J Blackburn
The copper centers of tyramine β-monooxygenase and its catalytic-site methionine variants: an X-ray absorption study.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2010;15(8):1195-207.
2010: Stephen R Wecksler; Stefan Stoll; Anthony T Iavarone; Erin M Imsand; Ha Tran; R David Britt; Judith P Klinman
Interaction of PqqE and PqqD in the pyrroloquinoline quinone (PQQ) biosynthetic pathway links PqqD to the radical SAM superfamily.
Chemical communications (Cambridge, England) 2010;46(37):7031-3.
2010: Zhi-Wei Chen; Saumen Datta; Jennifer L Dubois; Judith P Klinman; F Scott Mathews
Mutation at a strictly conserved, active site tyrosine in the copper amine oxidase leads to uncontrolled oxygenase activity.
Biochemistry 2010;49(34):7393-402.
2010: Olayinka A Oyeyemi; Kevin M Sours; Thomas Lee; Katheryn A Resing; Natalie G Ahn; Judith P Klinman
Temperature dependence of protein motions in a thermophilic dihydrofolate reductase and its relationship to catalytic efficiency.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(22):10074-9.
2010: Kevin P McCusker; Judith P Klinman
An active-site phenylalanine directs substrate binding and C-H cleavage in the alpha-ketoglutarate-dependent dioxygenase TauD.
Journal of the American Chemical Society 2010;132(14):5114-20.
2010: Cindy M Chang; Valerie J Klema; Bryan J Johnson; Minae Mure; Judith P Klinman; Carrie M Wilmot
Kinetic and structural analysis of substrate specificity in two copper amine oxidases from Hansenula polymorpha.
Biochemistry 2010;49(11):2540-50.
2009: Kevin P McCusker; Judith P Klinman
Modular behavior of tauD provides insight into the origin of specificity in alpha-ketoglutarate-dependent nonheme iron oxygenases.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(47):19791-5.
2009: Stephen R Wecksler; Stefan Stoll; Ha Tran; Olafur Magnusson; Shu-pao Wu; David King; R David Britt; Judith P Klinman
Pyrroloquinoline quinone biogenesis: demonstration that PqqE from Klebsiella pneumoniae is a radical S-adenosyl-L-methionine enzyme.
Biochemistry 2009;48(42):10151-61.
2009: Zachary D Nagel; Judith P Klinman
A 21st century revisionist's view at a turning point in enzymology.
Nature chemical biology 2009;5(8):543-50.
2009: Kristi J Humphreys; Liviu M Mirica; Yi Wang; Judith P Klinman
Galactose oxidase as a model for reactivity at a copper superoxide center.
Journal of the American Chemical Society 2009;131(13):4657-63.
2008: Sudhir C Sharma; Judith P Klinman
Experimental evidence for hydrogen tunneling when the isotopic arrhenius prefactor (A(H)/A(D)) is unity.
Journal of the American Chemical Society 2008;130(52):17632-3.
2008: Corinna R Hess; Zinian Wu; Adora Ng; Erin E Gray; Michele A McGuirl; Judith P Klinman
Hydroxylase activity of Met471Cys tyramine beta-monooxygenase.
Journal of the American Chemical Society 2008;130(36):11939-44.
2008: Liviu M Mirica; Kevin P McCusker; Jeffrey W Munos; Hung-wen Liu; Judith P Klinman
18O kinetic isotope effects in non-heme iron enzymes: probing the nature of Fe/O2 intermediates.
Journal of the American Chemical Society 2008;130(26):8122-3.
2008: Liviu M Mirica; Judith P Klinman
The nature of O2 activation by the ethylene-forming enzyme 1-aminocyclopropane-1-carboxylic acid oxidase.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(6):1814-9.
2008: Corinna R Hess; Michele M McGuirl; Judith P Klinman
Mechanism of the insect enzyme, tyramine beta-monooxygenase, reveals differences from the mammalian enzyme, dopamine beta-monooxygenase.
The Journal of biological chemistry 2008;283(6):3042-9.
2008: Matthew P Meyer; Diana R Tomchick; Judith P Klinman
Enzyme structure and dynamics affect hydrogen tunneling: the impact of a remote side chain (I553) in soybean lipoxygenase-1.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(4):1146-51.
2007: Richard W D Welford; Angel Lam; Liviu M Mirica; Judith P Klinman
Partial conversion of Hansenula polymorpha amine oxidase into a "plant" amine oxidase: implications for copper chemistry and mechanism.
Biochemistry 2007;46(38):10817-27.
2007: Olafur Magnusson; Jordan M RoseFigura; Hirohide Toyama; Robert Schwarzenbacher; Judith P Klinman
Pyrroloquinoline quinone biogenesis: characterization of PqqC and its H84N and H84A active site variants.
Biochemistry 2007;46(24):7174-86.
2007: Bryan J Johnson; Jordi Cohen; Richard W D Welford; Arwen R Pearson; Klaus Schulten; Judith P Klinman; Carrie M Wilmot
Exploring molecular oxygen pathways in Hansenula polymorpha copper-containing amine oxidase.
The Journal of biological chemistry 2007;282(24):17767-76.
2007: Judith P Klinman
How do enzymes activate oxygen without inactivating themselves?
Accounts of chemical research 2007;40(5):325-33.
2006: Matthew M Purdy; Laura S Koo; Paul R Ortiz de Montellano; Judith P Klinman
Mechanism of O2 activation by cytochrome P450cam studied by isotope effects and transient state kinetics.
Biochemistry 2006;45(51):15793-806.
2006: John P Evans; Ninian J Blackburn; Judith P Klinman
The catalytic role of the copper ligand H172 of peptidylglycine alpha-hydroxylating monooxygenase: a kinetic study of the H172A mutant.
Biochemistry 2006;45(51):15419-29.
2006: Julia Thrower; Liviu M Mirica; Kevin P McCusker; Judith P Klinman
Mechanistic investigations of 1-aminocyclopropane 1-carboxylic acid oxidase with alternate cyclic and acyclic substrates.
Biochemistry 2006;45(43):13108-17.
2006: Wadih Ghattas; Corinna R Hess; Gilles Iacazio; Renaud Hardré; Judith P Klinman; Marius Réglier
Pathway for the stereocontrolled Z and E production of alpha,alpha-difluorine-substituted phenyl butenoates.
The Journal of organic chemistry 2006;71(22):8618-21.
2006: Judith P Klinman
Linking protein structure and dynamics to catalysis: the role of hydrogen tunnelling.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2006;361(1472):1323-31.
2006: Zachary D Nagel; Judith P Klinman
Tunneling and dynamics in enzymatic hydride transfer.
Chemical reviews 2006;106(8):3095-118.
2006: Judith P Klinman
The role of tunneling in enzyme catalysis of C-H activation.
Biochimica et biophysica acta 2006;1757(8):981-7.
2006: Nicole M Samuels; Judith P Klinman
Investigation of Cu(I)-dependent 2,4,5-trihydroxyphenylalanine quinone biogenesis in Hansenula polymorpha amine oxidase.
The Journal of biological chemistry 2006;281(30):21114-8.
2006: Kenichi Takahashi; Judith P Klinman
Relationship of stopped flow to steady state parameters in the dimeric copper amine oxidase from Hansenula polymorpha and the role of zinc in inhibiting activity at alternate copper-containing subunits.
Biochemistry 2006;45(14):4683-94.
2006: Jennifer L DuBois; Judith P Klinman
Role of a strictly conserved active site tyrosine in cofactor genesis in the copper amine oxidase from Hansenula polymorpha.
Biochemistry 2006;45(10):3178-88.
2006: Judith P Klinman
The copper-enzyme family of dopamine beta-monooxygenase and peptidylglycine alpha-hydroxylating monooxygenase: resolving the chemical pathway for substrate hydroxylation.
The Journal of biological chemistry 2006;281(6):3013-6.
2005: Nicole M Samuels; Judith P Klinman
2,4,5-Trihydroxyphenylalanine quinone biogenesis in the copper amine oxidase from Hansenula polymorpha with the alternate metal nickel.
Biochemistry 2005;44(43):14308-17.
2005: Hui Sun Kim; Steven M Damo; Seok-Yong Lee; David E Wemmer; Judith P Klinman
Structure and hydride transfer mechanism of a moderate thermophilic dihydrofolate reductase from Bacillus stearothermophilus and comparison to its mesophilic and hyperthermophilic homologues.
Biochemistry 2005;44(34):11428-39.
2005: Jennifer L DuBois; Judith P Klinman
The nature of O2 reactivity leading to topa quinone in the copper amine oxidase from Hansenula polymorpha and its relationship to catalytic turnover.
Biochemistry 2005;44(34):11381-8.
2005: Julian Limburg; Minae Mure; Judith P Klinman
Cloning and characterization of histamine dehydrogenase from Nocardioides simplex.
Archives of biochemistry and biophysics 2005;436(1):8-22.
2005: Jennifer L DuBois; Judith P Klinman
Mechanism of post-translational quinone formation in copper amine oxidases and its relationship to the catalytic turnover.
Archives of biochemistry and biophysics 2005;433(1):255-65.
2004: Zhao-Xun Liang; Judith P Klinman
Structural bases of hydrogen tunneling in enzymes: progress and puzzles.
Current opinion in structural biology 2004;14(6):648-55.
2004: Justine P Roth; Roseanne Wincek; Gabrielle Nodet; Dale E Edmondson; William S McIntire; Judith P Klinman
Oxygen isotope effects on electron transfer to O2 probed using chemically modified flavins bound to glucose oxidase.
Journal of the American Chemical Society 2004;126(46):15120-31.
2004: Zhao-Xun Liang; Iason Tsigos; Thomas Lee; Vassilis Bouriotis; Katheryn A Resing; Natalie G Ahn; Judith P Klinman
Evidence for increased local flexibility in psychrophilic alcohol dehydrogenase relative to its thermophilic homologue.
Biochemistry 2004;43(46):14676-83.
2004: Wilson A Francisco; Georg Wille; Alan J Smith; David J Merkler; Judith P Klinman
Investigation of the pathway for inter-copper electron transfer in peptidylglycine alpha-amidating monooxygenase.
Journal of the American Chemical Society 2004;126(41):13168-9.
2004: Zhao-Xun Liang; Iason Tsigos; Vassilis Bouriotis; Judith P Klinman
Impact of protein flexibility on hydride-transfer parameters in thermophilic and psychrophilic alcohol dehydrogenases.
Journal of the American Chemical Society 2004;126(31):9500-1.
2004: Zhao-Xun Liang; Thomas Lee; Katheryn A Resing; Natalie G Ahn; Judith P Klinman
Thermal-activated protein mobility and its correlation with catalysis in thermophilic alcohol dehydrogenase.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(26):9556-61.
2004: Olafur Magnusson; Hirohide Toyama; Megumi Saeki; Ana Rojas; John C Reed; Robert C Liddington; Judith P Klinman; Robert Schwarzenbacher
Quinone biogenesis: Structure and mechanism of PqqC, the final catalyst in the production of pyrroloquinoline quinone.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(21):7913-8.
2004: Christopher Ceccarelli; Zhao-Xun Liang; Michael Strickler; Gerd Prehna; Barry M Goldstein; Judith P Klinman; Brian J Bahnson
Crystal structure and amide H/D exchange of binary complexes of alcohol dehydrogenase from Bacillus stearothermophilus: insight into thermostability and cofactor binding.
Biochemistry 2004;43(18):5266-77.
2004: Olafur Magnusson; Hirohide Toyama; Megumi Saeki; Robert Schwarzenbacher; Judith P Klinman
The structure of a biosynthetic intermediate of pyrroloquinoline quinone (PQQ) and elucidation of the final step of PQQ biosynthesis.
Journal of the American Chemical Society 2004;126(17):5342-3.
2004: Matthew M Purdy; Laura S Koo; Paul R. Ortiz de Montellano; Judith P Klinman
Steady-state kinetic investigation of cytochrome P450cam: interaction with redox partners and reaction with molecular oxygen.
Biochemistry 2004;43(1):271-81.
2004: Jennifer L DuBois; Judith P Klinman
Methods for characterizing TPQ-containing proteins.
Methods in enzymology 2004;378():17-31.
2003: John P Evans; Kyunghye Ahn; Judith P Klinman
Evidence that dioxygen and substrate activation are tightly coupled in dopamine beta-monooxygenase. Implications for the reactive oxygen species.
The Journal of biological chemistry 2003;278(50):49691-8.
2003: Michael J Knapp; Judith P Klinman
Kinetic studies of oxygen reactivity in soybean lipoxygenase-1.
Biochemistry 2003;42(39):11466-75.
2003: Minae Mure; Sophie X Wang; Judith P Klinman
Synthesis and characterization of model compounds of the lysine tyrosyl quinone cofactor of lysyl oxidase.
Journal of the American Chemical Society 2003;125(20):6113-25.
2003: Judith P Klinman
The multi-functional topa-quinone copper amine oxidases.
Biochimica et biophysica acta 2003;1647(1-2):131-7.
2003: Shiou-Chuan Tsai; Judith P Klinman
De novo design and utilization of photolabile caged substrates as probes of hydrogen tunneling with horse liver alcohol dehydrogenase at sub-zero temperatures: a cautionary note.
Bioorganic chemistry 2003;31(2):172-90.
2003: Wilson A Francisco; Ninian J Blackburn; Judith P Klinman
Oxygen and hydrogen isotope effects in an active site tyrosine to phenylalanine mutant of peptidylglycine alpha-hydroxylating monooxygenase: mechanistic implications.
Biochemistry 2003;42(7):1813-9.
2003: Justine P Roth; Judith P Klinman
Catalysis of electron transfer during activation of O2 by the flavoprotein glucose oxidase.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(1):62-7.
2002: Yoshio Goto; Judith P Klinman
Binding of dioxygen to non-metal sites in proteins: exploration of the importance of binding site size versus hydrophobicity in the copper amine oxidase from Hansenula polymorpha.
Biochemistry 2002;41(46):13637-43.
2002: Stephen A Mills; Yoshio Goto; Qiaojuan Su; Julie Plastino; Judith P Klinman
Mechanistic comparison of the cobalt-substituted and wild-type copper amine oxidase from Hansenula polymorpha.
Biochemistry 2002;41(34):10577-84.
2002: Minae Mure; Stephen A Mills; Judith P Klinman
Catalytic mechanism of the topa quinone containing copper amine oxidases.
Biochemistry 2002;41(30):9269-78.
2002: Wilson A Francisco; Michael J Knapp; Ninian J Blackburn; Judith P Klinman
Hydrogen tunneling in peptidylglycine alpha-hydroxylating monooxygenase.
Journal of the American Chemical Society 2002;124(28):8194-5.
2002: Sean L Seymour; Judith P Klinman
Comparison of rates and kinetic isotope effects using PEG-modified variants and glycoforms of glucose oxidase: the relationship of modification of the protein envelope to C-H activation and tunneling.
Biochemistry 2002;41(27):8747-58.
2002: Michael J Knapp; Judith P Klinman
Environmentally coupled hydrogen tunneling. Linking catalysis to dynamics.
European journal of biochemistry / FEBS 2002;269(13):3113-21.
2002: Michael J Knapp; Keith Rickert; Judith P Klinman
Temperature-dependent isotope effects in soybean lipoxygenase-1: correlating hydrogen tunneling with protein dynamics.
Journal of the American Chemical Society 2002;124(15):3865-74.
2002: Edward L Green; Nobuhumi Nakamura; David M Dooley; Judith P Klinman; Joann Sanders-Loehr
Rates of oxygen and hydrogen exchange as indicators of TPQ cofactor orientation in amine oxidases.
Biochemistry 2002;41(2):687-96.
2001: Judith P Klinman
How many ways to craft a cofactor?
Proceedings of the National Academy of Sciences of the United States of America 2001;98(26):14766-8.
2001: C Tang; Judith P Klinman
The catalytic function of bovine lysyl oxidase in the absence of copper.
The Journal of biological chemistry 2001;276(33):30575-8.
2001: J S Thrower; R Blalock; Judith P Klinman
Steady-state kinetics of substrate binding and iron release in tomato ACC oxidase.
Biochemistry 2001;40(32):9717-24.
2001: M J Knapp; F P Seebeck; Judith P Klinman
Steric control of oxygenation regiochemistry in soybean lipoxygenase-1.
Journal of the American Chemical Society 2001;123(12):2931-2.
2001: B Schwartz; A K Olgin; Judith P Klinman
The role of copper in topa quinone biogenesis and catalysis, as probed by azide inhibition of a copper amine oxidase from yeast.
Biochemistry 2001;40(9):2954-63.
2001: S Tsai ; Judith P Klinman
Probes of hydrogen tunneling with horse liver alcohol dehydrogenase at subzero temperatures.
Biochemistry 2001;40(7):2303-11.
2001: S S Stahl; Wilson A Francisco; Maarten Merkx; Judith P Klinman; Stephen J Lippard
Oxygen kinetic isotope effects in soluble methane monooxygenase.
The Journal of biological chemistry 2001;276(7):4549-53.
2001: JE Dove; Judith P Klinman
Trihydroxyphenylalanine quinone (TPQ) from copper amine oxidases and lysyl tyrosylquinone (LTQ) from lysyl oxidase.
Advances in protein chemistry 2001;58():141-74.
2001: Judith P Klinman
Life as aerobes: are there simple rules for activation of dioxygen by enzymes?
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2001;6(1):1-13.
2001: B Schwartz; Judith P Klinman
Mechanisms of biosynthesis of protein-derived redox cofactors.
Vitamins and hormones 2001;61():219-39.
2000: Z Chen; B Schwartz; NK Williams; R Li; Judith P Klinman; F Scott Mathews
Crystal structure at 2.5 A resolution of zinc-substituted copper amine oxidase of Hansenula polymorpha expressed in Escherichia coli.
Biochemistry 2000;39(32):9709-17.
2000: C R Melville; Edward L Green; Joann Sanders-Loehr; Judith P Klinman
Reassessment of the active site quino-cofactor proposed to occur in the Aspergillus niger amine oxidase AO-I from the properties of model compounds.
Biochemistry 2000;39(25):7589-94.
2000: B Schwartz; JE Dove; Judith P Klinman
Kinetic analysis of oxygen utilization during cofactor biogenesis in a copper-containing amine oxidase from yeast.
Biochemistry 2000;39(13):3699-707.
2000: JE Dove; B Schwartz; NK Williams; Judith P Klinman
Investigation of spectroscopic intermediates during copper-binding and TPQ formation in wild-type and active-site mutants of a copper-containing amine oxidase from yeast.
Biochemistry 2000;39(13):3690-8.
2000: JK Chin; Judith P Klinman
Probes of a role for remote binding interactions on hydrogen tunneling in the horse liver alcohol dehydrogenase reaction.
Biochemistry 2000;39(6):1278-84.
1999: K W Rickert; Judith P Klinman
Nature of hydrogen transfer in soybean lipoxygenase 1: separation of primary and secondary isotope effects.
Biochemistry 1999;38(38):12218-28.
1999: L Stewart; Judith P Klinman
Kinetic parameters for dimeric and tetrameric forms of bovine dopamine beta-monooxygenase and their relationship to non-Michaelis-Menten behavior.
FEBS letters 1999;454(3):229-32.
1999: A Kohen; Judith P Klinman
Hydrogen tunneling in biology.
Chemistry & biology 1999;6(7):R191-8.
1999: Qiaojuan Su; Judith P Klinman
Nature of oxygen activation in glucose oxidase from Aspergillus niger: the importance of electrostatic stabilization in superoxide formation.
Biochemistry 1999;38(26):8572-81.
1999: J Plastino; Edward L Green; Joann Sanders-Loehr; Judith P Klinman
An unexpected role for the active site base in cofactor orientation and flexibility in the copper amine oxidase from Hansenula polymorpha.
Biochemistry 1999;38(26):8204-16.
1999: A Kohen; Raffaele Cannio; Simonetta Bartolucci; Judith P Klinman
Enzyme dynamics and hydrogen tunnelling in a thermophilic alcohol dehydrogenase.
Nature 1999;399(6735):496-9.
1999: J M Hevel; Stephen A Mills; Judith P Klinman
Mutation of a strictly conserved, active-site residue alters substrate specificity and cofactor biogenesis in a copper amine oxidase.
Biochemistry 1999;38(12):3683-93.
1998: B Schwartz; Edward L Green; Joann Sanders-Loehr; Judith P Klinman
Relationship between conserved consensus site residues and the productive conformation for the TPQ cofactor in a copper-containing amine oxidase from yeast.
Biochemistry 1998;37(47):16591-600.
1998: Qiaojuan Su; Judith P Klinman
Probing the mechanism of proton coupled electron transfer to dioxygen: the oxidative half-reaction of bovine serum amine oxidase.
Biochemistry 1998;37(36):12513-25.
1998: TD Colby; Brian J Bahnson; JK Chin; Judith P Klinman; Barry M Goldstein
Active site modifications in a double mutant of liver alcohol dehydrogenase: structural studies of two enzyme-ligand complexes.
Biochemistry 1998;37(26):9295-304.
1998: Wilson A Francisco; David J Merkler; Ninian J Blackburn; Judith P Klinman
Kinetic mechanism and intrinsic isotope effects for the peptidylglycine alpha-amidating enzyme reaction.
Biochemistry 1998;37(22):8244-52.
1998: R Li; Judith P Klinman; F Scott Mathews
Copper amine oxidase from Hansenula polymorpha: the crystal structure determined at 2.4 A resolution reveals the active conformation.
Structure (London, England : 1993) 1998;6(3):293-307.
1997: Brian J Bahnson; TD Colby; JK Chin; Barry M Goldstein; Judith P Klinman
A link between protein structure and enzyme catalyzed hydrogen tunneling.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(24):12797-802.
1997: S X Wang; N Nakamura; Minae Mure; Judith P Klinman; Joann Sanders-Loehr
Characterization of the native lysine tyrosylquinone cofactor in lysyl oxidase by Raman spectroscopy.
The Journal of biological chemistry 1997;272(46):28841-4.
1997: N Nakamura; Pierre Moanne-Loccoz; Katsuyuki Tanizawa; Minae Mure; Shinnichiro Suzuki; Judith P Klinman; Joann Sanders-Loehr
Topaquinone-dependent amine oxidases: identification of reaction intermediates by Raman spectroscopy.
Biochemistry 1997;36(38):11479-86.
1997: D Cai; JE Dove; N Nakamura; Joann Sanders-Loehr; Judith P Klinman
Mechanism-based inactivation of a yeast methylamine oxidase mutant: implications for the functional role of the consensus sequence surrounding topaquinone.
Biochemistry 1997;36(38):11472-8.
1997: D Cai; NK Williams; Judith P Klinman
Effect of metal on 2,4,5-trihydroxyphenylalanine (topa) quinone biogenesis in the Hansenula polymorpha copper amine oxidase.
The Journal of biological chemistry 1997;272(31):19277-81.
1997: R Li; L Chen; D Cai; Judith P Klinman; F Scott Mathews
Crystallographic study of yeast copper amine oxidase.
Acta crystallographica. Section D, Biological crystallography 1997;53(Pt 4):364-70.
1997: A Kohen; T Jonsson; Judith P Klinman
Effects of protein glycosylation on catalysis: changes in hydrogen tunneling and enthalpy of activation in the glucose oxidase reaction.
Biochemistry 1997;36(9):2603-11.
1996: J E Dove; A J Smith; J Kuchar; D E Brown; David M Dooley; Judith P Klinman
Identification of the quinone cofactor in a lysyl oxidase from Pichia pastoris.
FEBS letters 1996;398(2-3):231-4.
1996: Judith P Klinman
New quinocofactors in eukaryotes.
The Journal of biological chemistry 1996;271(44):27189-92.
1996: M H Glickman; Judith P Klinman
Lipoxygenase reaction mechanism: demonstration that hydrogen abstraction from substrate precedes dioxygen binding during catalytic turnover.
Biochemistry 1996;35(39):12882-92.
1996: S X Wang; Minae Mure; K F Medzihradszky; Al L Burlingame; D E Brown; David M Dooley; A J Smith; Herbert M Kagan; Judith P Klinman
A crosslinked cofactor in lysyl oxidase: redox function for amino acid side chains.
Science (New York, N.Y.) 1996;273(5278):1078-84.
1996: J Plastino; Judith P Klinman
Limited proteolysis of Hansenula polymorpha yeast amine oxidase: isolation of a C-terminal fragment containing both a copper and quino-cofactor (FEBS 15979).
FEBS letters 1996;379(2):202.
1995: M H Glickman; Judith P Klinman
Nature of rate-limiting steps in the soybean lipoxygenase-1 reaction.
Biochemistry 1995;34(43):14077-92.
1995: J Plastino; Judith P Klinman
Limited proteolysis of Hansenula polymorpha yeast amine oxidase: isolation of a C-terminal fragment containing both a copper and quino-cofactor.
FEBS letters 1995;371(3):276-8.
1995: Pierre Moanne-Loccoz; N Nakamura; V Steinebach; Johannis A Duine; Minae Mure; Judith P Klinman; Joann Sanders-Loehr
Characterization of the topa quinone cofactor in amine oxidase from Escherichia coli by resonance Raman spectroscopy.
Biochemistry 1995;34(21):7020-6.
1995: Minae Mure; Judith P Klinman
Model studies of topa quinone: synthesis and characterization of topa quinone derivatives.
Methods in enzymology 1995;258():39-52.
1995: S M Janes; Judith P Klinman
Isolation of 2,4,5-trihydroxyphenylalanine quinone (topa quinone) from copper amine oxidases.
Methods in enzymology 1995;258():20-34.
1995: D Mu; Judith P Klinman
Cloning of mammalian topa quinone-containing enzymes.
Methods in enzymology 1995;258():114-22.
1995: Brian J Bahnson; Judith P Klinman
Hydrogen tunneling in enzyme catalysis.
Methods in enzymology 1995;249():373-97.
1994: D Cai; Judith P Klinman
Evidence of a self-catalytic mechanism of 2,4,5-trihydroxyphenylalanine quinone biogenesis in yeast copper amine oxidase.
The Journal of biological chemistry 1994;269(51):32039-42.
1994: T Jonsson; Dale E Edmondson; Judith P Klinman
Hydrogen tunneling in the flavoenzyme monoamine oxidase B.
Biochemistry 1994;33(49):14871-8.
1994: D Cai; Judith P Klinman
Copper amine oxidase: heterologous expression, purification, and characterization of an active enzyme in Saccharomyces cerevisiae.
Biochemistry 1994;33(24):7647-53.
1994: D Mu; Katalin F Medzihradszky; G W Adams; P Mayer; W M Hines; Al L Burlingame; A J Smith; D Cai; Judith P Klinman
Primary structures for a mammalian cellular and serum copper amine oxidase.
The Journal of biological chemistry 1994;269(13):9926-32.
1994: G Tian; J A Berry; Judith P Klinman
Oxygen-18 kinetic isotope effects in the dopamine beta-monooxygenase reaction: evidence for a new chemical mechanism in non-heme metallomonooxygenases.
Biochemistry 1994;33(1):226-34.
1994: Judith P Klinman; D Mu
Quinoenzymes in biology.
Annual review of biochemistry 1994;63():299-344.
1993: Brian J Bahnson; D H Park; K Kim; B V Plapp; Judith P Klinman
Unmasking of hydrogen tunneling in the horse liver alcohol dehydrogenase reaction by site-directed mutagenesis.
Biochemistry 1993;32(21):5503-7.
1993: C Hartmann; P Brzovic; Judith P Klinman
Spectroscopic detection of chemical intermediates in the reaction of para-substituted benzylamines with bovine serum amine oxidase.
Biochemistry 1993;32(9):2234-41.
1992: S M Janes; Monica Palcic; Christine Scaman; A J Smith; D E Brown; David M Dooley; Minae Mure; Judith P Klinman
Identification of topaquinone and its consensus sequence in copper amine oxidases.
Biochemistry 1992;31(48):12147-54.
1992: J Rucker; Y Cha; T Jonsson; K L Grant; Judith P Klinman
Role of internal thermodynamics in determining hydrogen tunneling in enzyme-catalyzed hydrogen transfer reactions.
Biochemistry 1992;31(46):11489-99.
1992: D Mu; S M Janes; A J Smith; D E Brown; David M Dooley; Judith P Klinman
Tyrosine codon corresponds to topa quinone at the active site of copper amine oxidases.
The Journal of biological chemistry 1992;267(12):7979-82.
1991: S C Kim; Judith P Klinman
Mechanism of inhibition of dopamine beta-monooxygenase by quinol and phenol derivatives, as determined by solvent and substrate deuterium isotope effects.
Biochemistry 1991;30(33):8138-44.
1991: B G Huyghe; Judith P Klinman
Activity of membranous dopamine beta-monooxygenase within chromaffin granule ghosts. Interaction with ascorbate.
The Journal of biological chemistry 1991;266(18):11544-50.
1991: L C Stewart; Judith P Klinman
Cooperativity in the dopamine beta-monooxygenase reaction. Evidence for ascorbate regulation of enzyme activity.
The Journal of biological chemistry 1991;266(18):11537-43.
1991: S M Janes; Judith P Klinman
An investigation of bovine serum amine oxidase active site stoichiometry: evidence for an aminotransferase mechanism involving two carbonyl cofactors per enzyme dimer.
Biochemistry 1991;30(18):4599-605.
1991: C Hartmann; Judith P Klinman
Structure-function studies of substrate oxidation by bovine serum amine oxidase: relationship to cofactor structure and mechanism.
Biochemistry 1991;30(18):4605-11.
1991: Judith P Klinman; David M Dooley; J A Duine; Peter F Knowles; B Mondovi; J J Villafranca
Status of the cofactor identity in copper oxidative enzymes.
FEBS letters 1991;282(1):1-4.
1991: D E Brown; Michele A McGuirl; David M Dooley; S M Janes; D Mu; Judith P Klinman
The organic functional group in copper-containing amine oxidases. Resonance Raman spectra are consistent with the presence of topa quinone (6-hydroxydopa quinone) in the active site.
The Journal of biological chemistry 1991;266(7):4049-51.
1990: S M Janes; D Mu; David E Wemmer; A J Smith; S Kaur; D Maltby; Al L Burlingame; Judith P Klinman
A new redox cofactor in eukaryotic enzymes: 6-hydroxydopa at the active site of bovine serum amine oxidase.
Science (New York, N.Y.) 1990;248(4958):981-7.
1990: M J Bossard; Judith P Klinman
Use of isotope effects to characterize intermediates in mechanism-based inactivation of dopamine beta-monooxygenase by beta-chlorophenethylamine.
The Journal of biological chemistry 1990;265(10):5640-7.
1990: C Hartmann; Judith P Klinman
Reductive trapping of substrate to methylamine oxidase from Arthrobacter P1.
FEBS letters 1990;261(2):441-4.
1989: J Taljanidisz; L Stewart; A J Smith; Judith P Klinman
Structure of bovine adrenal dopamine beta-monooxygenase, as deduced from cDNA and protein sequencing: evidence that the membrane-bound form of the enzyme is anchored by an uncleaved signal peptide.
Biochemistry 1989;28(26):10054-61.
1989: Judith P Klinman
Quantum mechanical effects in enzyme-catalysed hydrogen transfer reactions.
Trends in biochemical sciences 1989;14(9):368-73.
1989: K L Grant; Judith P Klinman
Evidence that both protium and deuterium undergo significant tunneling in the reaction catalyzed by bovine serum amine oxidase.
Biochemistry 1989;28(16):6597-605.
1989: N G Ahn; Judith P Klinman
Nature of rate-limiting steps in a compartmentalized enzyme system. Quantitation of dopamine transport and hydroxylation rates in resealed chromaffin granule ghosts.
The Journal of biological chemistry 1989;264(21):12259-65.
1989: M C Brenner; Judith P Klinman
Correlation of copper valency with product formation in single turnovers of dopamine beta-monooxygenase.
Biochemistry 1989;28(11):4664-70.
1989: M C Brenner; C J Murray; Judith P Klinman
Rapid freeze- and chemical-quench studies of dopamine beta-monooxygenase: comparison of pre-steady-state and steady-state parameters.
Biochemistry 1989;28(11):4656-64.
1989: Y Cha; C J Murray; Judith P Klinman
Hydrogen tunneling in enzyme reactions.
Science (New York, N.Y.) 1989;243(4896):1325-30.
1988: Judith P Klinman; S Janes; C Hartmann
Mechanism of reaction of the copper amine oxidases.
Pharmacological research communications 1988;20 Suppl 4():35-7.
1988: L C Stewart; Judith P Klinman
Bovine membranous dopamine beta-hydroxylase is not anchored via covalently attached phosphatidylinositol.
The Journal of biological chemistry 1988;263(25):12183-6.
1988: L C Stewart; Judith P Klinman
Dopamine beta-hydroxylase of adrenal chromaffin granules: structure and function.
Annual review of biochemistry 1988;57():551-92.
1988: C Hartmann; Judith P Klinman
Pyrroloquinoline quinone: a new redox cofactor in eukaryotic enzymes.
BioFactors (Oxford, England) 1988;1(1):41-9.
1988: Judith P Klinman; M Brenner
Role of copper and catalytic mechanism in the copper monooxygenase, dopamine beta-hydroxylase (D beta H).
Progress in clinical and biological research 1988;274():227-48.
1987: L C Stewart; Judith P Klinman
Characterization of alternate reductant binding and electron transfer in the dopamine beta-monooxygenase reaction.
Biochemistry 1987;26(17):5302-9.
1987: N G Ahn; Judith P Klinman
Activation of dopamine beta-monooxygenase by external and internal electron donors in resealed chromaffin granule ghosts.
The Journal of biological chemistry 1987;262(4):1485-92.
1987: C Hartmann; Judith P Klinman
Reductive trapping of substrate to bovine plasma amine oxidase.
The Journal of biological chemistry 1987;262(3):962-5.
1986: M J Bossard; Judith P Klinman
Mechanism-based inhibition of dopamine beta-monooxygenase by aldehydes and amides.
The Journal of biological chemistry 1986;261(35):16421-7.
1986: M F Farnum; Judith P Klinman
Stereochemical probes of bovine plasma amine oxidase: evidence for mirror image processing and a syn abstraction of hydrogens from C-1 and C-2 of dopamine.
Biochemistry 1986;25(20):6028-36.
1986: M Farnum; Monica Palcic; Judith P Klinman
pH dependence of deuterium isotope effects and tritium exchange in the bovine plasma amine oxidase reaction: a role for single-base catalysis in amine oxidation and imine exchange.
Biochemistry 1986;25(8):1898-904.
1985: Susan Miller; Judith P Klinman
Secondary isotope effects and structure-reactivity correlations in the dopamine beta-monooxygenase reaction: evidence for a chemical mechanism.
Biochemistry 1985;24(9):2114-27.
1984: J B Mangold; Judith P Klinman
Mechanism-based inactivation of dopamine beta-monooxygenase by beta-chlorophenethylamine.
The Journal of biological chemistry 1984;259(12):7772-9.
1984: Judith P Klinman; M Krueger; M Brenner; Dale E Edmondson
Evidence for two copper atoms/subunit in dopamine beta-monooxygenase catalysis.
The Journal of biological chemistry 1984;259(6):3399-402.
1983: Monica Palcic; Judith P Klinman
Isotopic probes yield microscopic constants: separation of binding energy from catalytic efficiency in the bovine plasma amine oxidase reaction.
Biochemistry 1983;22(25):5957-66.
1983: N Ahn; Judith P Klinman
Mechanism of modulation of dopamine beta-monooxygenase by pH and fumarate as deduced from initial rate and primary deuterium isotope effect studies.
Biochemistry 1983;22(13):3096-106.
1983: Susan Miller; Judith P Klinman
Magnitude of intrinsic isotope effects in the dopamine beta-monooxygenase reaction.
Biochemistry 1983;22(13):3091-6.
1982: Judith P Klinman; M Krueger
Dopamine beta-hydroxylase: activity and inhibition in the presence of beta-substituted phenethylamines.
Biochemistry 1982;21(1):67-75.
1982: Susan Miller; Judith P Klinman
Deduction of kinetic mechanisms from primary hydrogen isotope effects: dopamine beta-monooxygenase--a case history.
Methods in enzymology 1982;87():711-32.
1981: R R Allen; Judith P Klinman
Stereochemistry and kinetic isotope effects in the decarboxylation of S-adenosylmethionine catalyzed by the pyruvyl enzyme, S-adenosylmethionine decarboxylase.
The Journal of biological chemistry 1981;256(7):3233-9.
1981: Judith P Klinman
Probes of mechanism and transition-state structure in the alcohol dehydrogenase reaction.
CRC critical reviews in biochemistry 1981;10(1):39-78.
1980: Judith P Klinman; H Humphries; J G Voet
Deduction of kinetic mechanism in multisubstrate enzyme reactions from tritium isotope effects. Application to dopamine beta-hydroxylase.
The Journal of biological chemistry 1980;255(24):11648-51.
1980: K M Welsh; Donald J Creighton; Judith P Klinman
Transition-state structure in the yeast alcohol dehydrogenase reaction: the magnitude of solvent and alpha-secondary hydrogen isotope effects.
Biochemistry 1980;19(10):2005-16.