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Judith Klinman

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Co-Publications
Name
9
Mure, Minae
8
Sanders-Loehr, Joann
7
Dooley, David
6
Schwartz, B
5
Mirica, Liviu
5
Bahnson, Brian
5
Francisco, Wilson
5
Liang, Zhao-Xun
4
Green, Edward
4
Knapp, Michael
4
Dove, JE
4
DuBois, Jennifer
4
Blackburn, Ninian
4
Magnusson, Olafur
3
Hess, Corinna

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Publications

TOP 3
Wecksler Stephen R; Stoll Stefan; Tran Ha; Magnusson Olafur T; Wu Shu-Pao; King David; Britt R David; Klinman Judith P
Pyrroloquinoline quinone biogenesis: demonstration that PqqE from Klebsiella pneumoniae is a radical S-adenosyl-L-methionine enzyme.
Nagel Zachary D; Klinman Judith P
A 21st century revisionist's view at a turning point in enzymology.
Humphreys Kristi J; Mirica Liviu M; Wang Yi; Klinman Judith P
Galactose oxidase as a model for reactivity at a copper superoxide center.

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All Publications

2009: Wecksler Stephen R; Stoll Stefan; Tran Ha; Magnusson Olafur T; Wu Shu-Pao; King David; Britt R David; Klinman Judith P
Pyrroloquinoline quinone biogenesis: demonstration that PqqE from Klebsiella pneumoniae is a radical S-adenosyl-L-methionine enzyme.
Biochemistry 2009;48(42):10151-61.
2009: Nagel Zachary D; Klinman Judith P
A 21st century revisionist's view at a turning point in enzymology.
Nature chemical biology 2009;5(8):543-50.
2009: Humphreys Kristi J; Mirica Liviu M; Wang Yi; Klinman Judith P
Galactose oxidase as a model for reactivity at a copper superoxide center.
Journal of the American Chemical Society 2009;131(13):4657-63.
2008: Sharma Sudhir C; Klinman Judith P
Experimental evidence for hydrogen tunneling when the isotopic arrhenius prefactor (A(H)/A(D)) is unity.
Journal of the American Chemical Society 2008;130(52):17632-3.
2008: Hess Corinna R; Wu Zinian; Ng Adora; Gray Erin E; McGuirl Michele A; Klinman Judith P
Hydroxylase activity of Met471Cys tyramine beta-monooxygenase.
Journal of the American Chemical Society 2008;130(36):11939-44.
2008: Mirica Liviu M; McCusker Kevin P; Munos Jeffrey W; Liu Hung-wen; Klinman Judith P
18O kinetic isotope effects in non-heme iron enzymes: probing the nature of Fe/O2 intermediates.
Journal of the American Chemical Society 2008;130(26):8122-3.
2008: Mirica Liviu M; Klinman Judith P
The nature of O2 activation by the ethylene-forming enzyme 1-aminocyclopropane-1-carboxylic acid oxidase.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(6):1814-9.
2008: Hess Corinna R; McGuirl Michele M; Klinman Judith P
Mechanism of the insect enzyme, tyramine beta-monooxygenase, reveals differences from the mammalian enzyme, dopamine beta-monooxygenase.
The Journal of biological chemistry 2008;283(6):3042-9.
2008: Meyer Matthew P; Tomchick Diana R; Klinman Judith P
Enzyme structure and dynamics affect hydrogen tunneling: the impact of a remote side chain (I553) in soybean lipoxygenase-1.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(4):1146-51.
2007: Welford Richard W D; Lam Angel; Mirica Liviu M; Klinman Judith P
Partial conversion of Hansenula polymorpha amine oxidase into a "plant" amine oxidase: implications for copper chemistry and mechanism.
Biochemistry 2007;46(38):10817-27.
2007: Magnusson Olafur Th; RoseFigura Jordan M; Toyama Hirohide; Schwarzenbacher Robert; Klinman Judith P
Pyrroloquinoline quinone biogenesis: characterization of PqqC and its H84N and H84A active site variants.
Biochemistry 2007;46(24):7174-86.
2007: Johnson Bryan J; Cohen Jordi; Welford Richard W; Pearson Arwen R; Schulten Klaus; Klinman Judith P; Wilmot Carrie M
Exploring molecular oxygen pathways in Hansenula polymorpha copper-containing amine oxidase.
The Journal of biological chemistry 2007;282(24):17767-76.
2007: Klinman Judith P
How do enzymes activate oxygen without inactivating themselves?
Accounts of chemical research 2007;40(5):325-33.
2006: Purdy Matthew M; Koo Laura S; de Montellano Paul R Ortiz; Klinman Judith P
Mechanism of O2 activation by cytochrome P450cam studied by isotope effects and transient state kinetics.
Biochemistry 2006;45(51):15793-806.
2006: Evans John P; Blackburn Ninian J; Klinman Judith P
The catalytic role of the copper ligand H172 of peptidylglycine alpha-hydroxylating monooxygenase: a kinetic study of the H172A mutant.
Biochemistry 2006;45(51):15419-29.
2006: Ghattas Wadih; Hess Corinna R; Iacazio Gilles; Hardré Renaud; Klinman Judith P; Réglier Marius
Pathway for the stereocontrolled Z and E production of alpha,alpha-difluorine-substituted phenyl butenoates.
The Journal of organic chemistry 2006;71(22):8618-21.
2006: Thrower Julia; Mirica Liviu M; McCusker Kevin P; Klinman Judith P
Mechanistic investigations of 1-aminocyclopropane 1-carboxylic acid oxidase with alternate cyclic and acyclic substrates.
Biochemistry 2006;45(43):13108-17.
2006: Nagel Zachary D; Klinman Judith P
Tunneling and dynamics in enzymatic hydride transfer.
Chemical reviews 2006;106(8):3095-118.
2006: Klinman Judith P
Linking protein structure and dynamics to catalysis: the role of hydrogen tunnelling.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2006;361(1472):1323-31.
2006: Klinman Judith P
The role of tunneling in enzyme catalysis of C-H activation.
Biochimica et biophysica acta 2006;1757(8):981-7.
2006: Samuels Nicole M; Klinman Judith P
Investigation of Cu(I)-dependent 2,4,5-trihydroxyphenylalanine quinone biogenesis in Hansenula polymorpha amine oxidase.
The Journal of biological chemistry 2006;281(30):21114-8.
2006: Takahashi Kenichi; Klinman Judith P
Relationship of stopped flow to steady state parameters in the dimeric copper amine oxidase from Hansenula polymorpha and the role of zinc in inhibiting activity at alternate copper-containing subunits.
Biochemistry 2006;45(14):4683-94.
2006: DuBois Jennifer L; Klinman Judith P
Role of a strictly conserved active site tyrosine in cofactor genesis in the copper amine oxidase from Hansenula polymorpha.
Biochemistry 2006;45(10):3178-88.
2006: Klinman Judith P
The copper-enzyme family of dopamine beta-monooxygenase and peptidylglycine alpha-hydroxylating monooxygenase: resolving the chemical pathway for substrate hydroxylation.
The Journal of biological chemistry 2006;281(6):3013-6.
2005: Samuels Nicole M; Klinman Judith P
2,4,5-Trihydroxyphenylalanine quinone biogenesis in the copper amine oxidase from Hansenula polymorpha with the alternate metal nickel.
Biochemistry 2005;44(43):14308-17.
2005: Kim Hui Sun; Damo Steven M; Lee Seok-Yong; Wemmer David; Klinman Judith P
Structure and hydride transfer mechanism of a moderate thermophilic dihydrofolate reductase from Bacillus stearothermophilus and comparison to its mesophilic and hyperthermophilic homologues.
Biochemistry 2005;44(34):11428-39.
2005: DuBois Jennifer L; Klinman Judith P
The nature of O2 reactivity leading to topa quinone in the copper amine oxidase from Hansenula polymorpha and its relationship to catalytic turnover.
Biochemistry 2005;44(34):11381-8.
2005: Limburg Julian; Mure Minae; Klinman Judith P
Cloning and characterization of histamine dehydrogenase from Nocardioides simplex.
Archives of biochemistry and biophysics 2005;436(1):8-22.
2005: Dubois Jennifer L; Klinman Judith P
Mechanism of post-translational quinone formation in copper amine oxidases and its relationship to the catalytic turnover.
Archives of biochemistry and biophysics 2005;433(1):255-65.
2004: Liang Zhao-Xun; Klinman Judith P
Structural bases of hydrogen tunneling in enzymes: progress and puzzles.
Current opinion in structural biology 2004;14(6):648-55.
2004: Roth Justine P; Wincek Roseanne; Nodet Gabrielle; Edmondson Dale E; McIntire William S; Klinman Judith P
Oxygen isotope effects on electron transfer to O2 probed using chemically modified flavins bound to glucose oxidase.
Journal of the American Chemical Society 2004;126(46):15120-31.
2004: Liang Zhao-Xun; Tsigos Iason; Lee Thomas; Bouriotis Vassilis; Resing Katheryn A; Ahn Natalie G; Klinman Judith P
Evidence for increased local flexibility in psychrophilic alcohol dehydrogenase relative to its thermophilic homologue.
Biochemistry 2004;43(46):14676-83.
2004: Francisco Wilson A; Wille Georg; Smith Alan J; Merkler David J; Klinman Judith P
Investigation of the pathway for inter-copper electron transfer in peptidylglycine alpha-amidating monooxygenase.
Journal of the American Chemical Society 2004;126(41):13168-9.
2004: Liang Zhao-Xun; Tsigos Iason; Bouriotis Vassilis; Klinman Judith P
Impact of protein flexibility on hydride-transfer parameters in thermophilic and psychrophilic alcohol dehydrogenases.
Journal of the American Chemical Society 2004;126(31):9500-1.
2004: Liang Zhao-Xun; Lee Thomas; Resing Katheryn A; Ahn Natalie G; Klinman Judith P
Thermal-activated protein mobility and its correlation with catalysis in thermophilic alcohol dehydrogenase.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(26):9556-61.
2004: Magnusson Olafur Th; Toyama Hirohide; Saeki Megumi; Rojas Ana; Reed John C; Liddington Robert C; Klinman Judith P; Schwarzenbacher Robert
Quinone biogenesis: Structure and mechanism of PqqC, the final catalyst in the production of pyrroloquinoline quinone.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(21):7913-8.
2004: Ceccarelli Christopher; Liang Zhao-Xun; Strickler Michael; Prehna Gerd; Goldstein Barry M; Klinman Judith P; Bahnson Brian J
Crystal structure and amide H/D exchange of binary complexes of alcohol dehydrogenase from Bacillus stearothermophilus: insight into thermostability and cofactor binding.
Biochemistry 2004;43(18):5266-77.
2004: Magnusson Olafur T; Toyama Hirohide; Saeki Megumi; Schwarzenbacher Robert; Klinman Judith P
The structure of a biosynthetic intermediate of pyrroloquinoline quinone (PQQ) and elucidation of the final step of PQQ biosynthesis.
Journal of the American Chemical Society 2004;126(17):5342-3.
2004: Purdy Matthew M; Koo Laura S; Ortiz de Montellano Paul R; Klinman Judith P
Steady-state kinetic investigation of cytochrome P450cam: interaction with redox partners and reaction with molecular oxygen.
Biochemistry 2004;43(1):271-81.
2004: DuBois Jennifer L; Klinman Judith P
Methods for characterizing TPQ-containing proteins.
Methods in enzymology 2004;378():17-31.
2003: Evans John P; Ahn Kyunghye; Klinman Judith P
Evidence that dioxygen and substrate activation are tightly coupled in dopamine beta-monooxygenase. Implications for the reactive oxygen species.
The Journal of biological chemistry 2003;278(50):49691-8.
2003: Knapp Michael J; Klinman Judith P
Kinetic studies of oxygen reactivity in soybean lipoxygenase-1.
Biochemistry 2003;42(39):11466-75.
2003: Mure Minae; Wang Sophie X; Klinman Judith P
Synthesis and characterization of model compounds of the lysine tyrosyl quinone cofactor of lysyl oxidase.
Journal of the American Chemical Society 2003;125(20):6113-25.
2003: Tsai Shiou-Chuan; Klinman Judith P
De novo design and utilization of photolabile caged substrates as probes of hydrogen tunneling with horse liver alcohol dehydrogenase at sub-zero temperatures: a cautionary note.
Bioorganic chemistry 2003;31(2):172-90.
2003: Klinman Judith P
The multi-functional topa-quinone copper amine oxidases.
Biochimica et biophysica acta 2003;1647(1-2):131-7.
2003: Francisco Wilson A; Blackburn Ninian J; Klinman Judith P
Oxygen and hydrogen isotope effects in an active site tyrosine to phenylalanine mutant of peptidylglycine alpha-hydroxylating monooxygenase: mechanistic implications.
Biochemistry 2003;42(7):1813-9.
2003: Roth Justine P; Klinman Judith P
Catalysis of electron transfer during activation of O2 by the flavoprotein glucose oxidase.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(1):62-7.
2002: Goto Yoshio; Klinman Judith P
Binding of dioxygen to non-metal sites in proteins: exploration of the importance of binding site size versus hydrophobicity in the copper amine oxidase from Hansenula polymorpha.
Biochemistry 2002;41(46):13637-43.
2002: Mills Stephen A; Goto Yoshio; Su Qiaojuan; Plastino Julie; Klinman Judith P
Mechanistic comparison of the cobalt-substituted and wild-type copper amine oxidase from Hansenula polymorpha.
Biochemistry 2002;41(34):10577-84.
2002: Mure Minae; Mills Stephen A; Klinman Judith P
Catalytic mechanism of the topa quinone containing copper amine oxidases.
Biochemistry 2002;41(30):9269-78.
2002: Francisco Wilson A; Knapp Michael J; Blackburn Ninian J; Klinman Judith P
Hydrogen tunneling in peptidylglycine alpha-hydroxylating monooxygenase.
Journal of the American Chemical Society 2002;124(28):8194-5.
2002: Seymour Sean L; Klinman Judith P
Comparison of rates and kinetic isotope effects using PEG-modified variants and glycoforms of glucose oxidase: the relationship of modification of the protein envelope to C-H activation and tunneling.
Biochemistry 2002;41(27):8747-58.
2002: Knapp Michael J; Klinman Judith P
Environmentally coupled hydrogen tunneling. Linking catalysis to dynamics.
European journal of biochemistry / FEBS 2002;269(13):3113-21.
2002: Knapp Michael J; Rickert Keith; Klinman Judith P
Temperature-dependent isotope effects in soybean lipoxygenase-1: correlating hydrogen tunneling with protein dynamics.
Journal of the American Chemical Society 2002;124(15):3865-74.
2002: Green Edward L; Nakamura Nobuhumi; Dooley David M; Klinman Judith P; Sanders-Loehr Joann
Rates of oxygen and hydrogen exchange as indicators of TPQ cofactor orientation in amine oxidases.
Biochemistry 2002;41(2):687-96.
2001: Klinman J P
How many ways to craft a cofactor?
Proceedings of the National Academy of Sciences of the United States of America 2001;98(26):14766-8.
2001: Thrower J S; Blalock R; Klinman J P
Steady-state kinetics of substrate binding and iron release in tomato ACC oxidase.
Biochemistry 2001;40(32):9717-24.
2001: Tang C; Klinman J P
The catalytic function of bovine lysyl oxidase in the absence of copper.
The Journal of biological chemistry 2001;276(33):30575-8.
2001: Knapp M J; Seebeck F P; Klinman J P
Steric control of oxygenation regiochemistry in soybean lipoxygenase-1.
Journal of the American Chemical Society 2001;123(12):2931-2.
2001: Schwartz B; Olgin A K; Klinman J P
The role of copper in topa quinone biogenesis and catalysis, as probed by azide inhibition of a copper amine oxidase from yeast.
Biochemistry 2001;40(9):2954-63.
2001: Tsai S; Klinman J P
Probes of hydrogen tunneling with horse liver alcohol dehydrogenase at subzero temperatures.
Biochemistry 2001;40(7):2303-11.
2001: Stahl S S; Francisco W A; Merkx M; Klinman J P; Lippard S J
Oxygen kinetic isotope effects in soluble methane monooxygenase.
The Journal of biological chemistry 2001;276(7):4549-53.
2001: Klinman J P
Life as aerobes: are there simple rules for activation of dioxygen by enzymes?
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2001;6(1):1-13.
2001: Dove J E; Klinman J P
Trihydroxyphenylalanine quinone (TPQ) from copper amine oxidases and lysyl tyrosylquinone (LTQ) from lysyl oxidase.
Advances in protein chemistry 2001;58():141-74.
2001: Schwartz B; Klinman J P
Mechanisms of biosynthesis of protein-derived redox cofactors.
Vitamins and hormones 2001;61():219-39.
2000: Chen Z; Schwartz B; Williams N K; Li R; Klinman J P; Mathews F S
Crystal structure at 2.5 A resolution of zinc-substituted copper amine oxidase of Hansenula polymorpha expressed in Escherichia coli.
Biochemistry 2000;39(32):9709-17.
2000: Melville C R; Green E L; Sanders-Loehr J; Klinman J P
Reassessment of the active site quino-cofactor proposed to occur in the Aspergillus niger amine oxidase AO-I from the properties of model compounds.
Biochemistry 2000;39(25):7589-94.
2000: Schwartz B; Dove J E; Klinman J P
Kinetic analysis of oxygen utilization during cofactor biogenesis in a copper-containing amine oxidase from yeast.
Biochemistry 2000;39(13):3699-707.
2000: Dove J E; Schwartz B; Williams N K; Klinman J P
Investigation of spectroscopic intermediates during copper-binding and TPQ formation in wild-type and active-site mutants of a copper-containing amine oxidase from yeast.
Biochemistry 2000;39(13):3690-8.
2000: Chin J K; Klinman J P
Probes of a role for remote binding interactions on hydrogen tunneling in the horse liver alcohol dehydrogenase reaction.
Biochemistry 2000;39(6):1278-84.
1999: Rickert K W; Klinman J P
Nature of hydrogen transfer in soybean lipoxygenase 1: separation of primary and secondary isotope effects.
Biochemistry 1999;38(38):12218-28.
1999: Stewart L; Klinman J P
Kinetic parameters for dimeric and tetrameric forms of bovine dopamine beta-monooxygenase and their relationship to non-Michaelis-Menten behavior.
FEBS letters 1999;454(3):229-32.
1999: Kohen A; Klinman J P
Hydrogen tunneling in biology.
Chemistry & biology 1999;6(7):R191-8.
1999: Su Q; Klinman J P
Nature of oxygen activation in glucose oxidase from Aspergillus niger: the importance of electrostatic stabilization in superoxide formation.
Biochemistry 1999;38(26):8572-81.
1999: Plastino J; Green E L; Sanders-Loehr J; Klinman J P
An unexpected role for the active site base in cofactor orientation and flexibility in the copper amine oxidase from Hansenula polymorpha.
Biochemistry 1999;38(26):8204-16.
1999: Kohen A; Cannio R; Bartolucci S; Klinman J P
Enzyme dynamics and hydrogen tunnelling in a thermophilic alcohol dehydrogenase.
Nature 1999;399(6735):496-9.
1999: Hevel J M; Mills S A; Klinman J P
Mutation of a strictly conserved, active-site residue alters substrate specificity and cofactor biogenesis in a copper amine oxidase.
Biochemistry 1999;38(12):3683-93.
1998: Schwartz B; Green E L; Sanders-Loehr J; Klinman J P
Relationship between conserved consensus site residues and the productive conformation for the TPQ cofactor in a copper-containing amine oxidase from yeast.
Biochemistry 1998;37(47):16591-600.
1998: Su Q; Klinman J P
Probing the mechanism of proton coupled electron transfer to dioxygen: the oxidative half-reaction of bovine serum amine oxidase.
Biochemistry 1998;37(36):12513-25.
1998: Colby T D; Bahnson B J; Chin J K; Klinman J P; Goldstein B M
Active site modifications in a double mutant of liver alcohol dehydrogenase: structural studies of two enzyme-ligand complexes.
Biochemistry 1998;37(26):9295-304.
1998: Francisco W A; Merkler D J; Blackburn N J; Klinman J P
Kinetic mechanism and intrinsic isotope effects for the peptidylglycine alpha-amidating enzyme reaction.
Biochemistry 1998;37(22):8244-52.
1998: Li R; Klinman J P; Mathews F S
Copper amine oxidase from Hansenula polymorpha: the crystal structure determined at 2.4 A resolution reveals the active conformation.
Structure (London, England : 1993) 1998;6(3):293-307.
1997: Bahnson B J; Colby T D; Chin J K; Goldstein B M; Klinman J P
A link between protein structure and enzyme catalyzed hydrogen tunneling.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(24):12797-802.
1997: Wang S X; Nakamura N; Mure M; Klinman J P; Sanders-Loehr J
Characterization of the native lysine tyrosylquinone cofactor in lysyl oxidase by Raman spectroscopy.
The Journal of biological chemistry 1997;272(46):28841-4.
1997: Nakamura N; Moënne-Loccoz P; Tanizawa K; Mure M; Suzuki S; Klinman J P; Sanders-Loehr J
Topaquinone-dependent amine oxidases: identification of reaction intermediates by Raman spectroscopy.
Biochemistry 1997;36(38):11479-86.
1997: Cai D; Dove J; Nakamura N; Sanders-Loehr J; Klinman J P
Mechanism-based inactivation of a yeast methylamine oxidase mutant: implications for the functional role of the consensus sequence surrounding topaquinone.
Biochemistry 1997;36(38):11472-8.
1997: Cai D; Williams N K; Klinman J P
Effect of metal on 2,4,5-trihydroxyphenylalanine (topa) quinone biogenesis in the Hansenula polymorpha copper amine oxidase.
The Journal of biological chemistry 1997;272(31):19277-81.
1997: Li R; Chen L; Cai D; Klinman J P; Mathews F S
Crystallographic study of yeast copper amine oxidase.
Acta crystallographica. Section D, Biological crystallography 1997;53(Pt 4):364-70.
1997: Kohen A; Jonsson T; Klinman J P
Effects of protein glycosylation on catalysis: changes in hydrogen tunneling and enthalpy of activation in the glucose oxidase reaction.
Biochemistry 1997;36(9):2603-11.
1996: Dove J E; Smith A J; Kuchar J; Brown D E; Dooley D M; Klinman J P
Identification of the quinone cofactor in a lysyl oxidase from Pichia pastoris.
FEBS letters 1996;398(2-3):231-4.
1996: Klinman J P
New quinocofactors in eukaryotes.
The Journal of biological chemistry 1996;271(44):27189-92.
1996: Glickman M H; Klinman J P
Lipoxygenase reaction mechanism: demonstration that hydrogen abstraction from substrate precedes dioxygen binding during catalytic turnover.
Biochemistry 1996;35(39):12882-92.
1996: Wang S X; Mure M; Medzihradszky K F; Burlingame A L; Brown D E; Dooley D M; Smith A J; Kagan H M; Klinman J P
A crosslinked cofactor in lysyl oxidase: redox function for amino acid side chains.
Science (New York, N.Y.) 1996;273(5278):1078-84.
1996: Plastino J; Klinman J P
Limited proteolysis of Hansenula polymorpha yeast amine oxidase: isolation of a C-terminal fragment containing both a copper and quino-cofactor (FEBS 15979).
FEBS letters 1996;379(2):202.
1995: Glickman M H; Klinman J P
Nature of rate-limiting steps in the soybean lipoxygenase-1 reaction.
Biochemistry 1995;34(43):14077-92.
1995: Plastino J; Klinman J P
Limited proteolysis of Hansenula polymorpha yeast amine oxidase: isolation of a C-terminal fragment containing both a copper and quino-cofactor.
FEBS letters 1995;371(3):276-8.
1995: Moënne-Loccoz P; Nakamura N; Steinebach V; Duine J A; Mure M; Klinman J P; Sanders-Loehr J
Characterization of the topa quinone cofactor in amine oxidase from Escherichia coli by resonance Raman spectroscopy.
Biochemistry 1995;34(21):7020-6.
1995: Mure M; Klinman J P
Model studies of topa quinone: synthesis and characterization of topa quinone derivatives.
Methods in enzymology 1995;258():39-52.
1995: Janes S M; Klinman J P
Isolation of 2,4,5-trihydroxyphenylalanine quinone (topa quinone) from copper amine oxidases.
Methods in enzymology 1995;258():20-34.
1995: Mu D; Klinman J P
Cloning of mammalian topa quinone-containing enzymes.
Methods in enzymology 1995;258():114-22.
1995: Bahnson B J; Klinman J P
Hydrogen tunneling in enzyme catalysis.
Methods in enzymology 1995;249():373-97.
1994: Jonsson T; Edmondson D E; Klinman J P
Hydrogen tunneling in the flavoenzyme monoamine oxidase B.
Biochemistry 1994;33(49):14871-8.
1994: Cai D; Klinman J P
Evidence of a self-catalytic mechanism of 2,4,5-trihydroxyphenylalanine quinone biogenesis in yeast copper amine oxidase.
The Journal of biological chemistry 1994;269(51):32039-42.
1994: Cai D; Klinman J P
Copper amine oxidase: heterologous expression, purification, and characterization of an active enzyme in Saccharomyces cerevisiae.
Biochemistry 1994;33(24):7647-53.
1994: Mu D; Medzihradszky K F; Adams G W; Mayer P; Hines W M; Burlingame A L; Smith A J; Cai D; Klinman J P
Primary structures for a mammalian cellular and serum copper amine oxidase.
The Journal of biological chemistry 1994;269(13):9926-32.
1994: Tian G; Berry J A; Klinman J P
Oxygen-18 kinetic isotope effects in the dopamine beta-monooxygenase reaction: evidence for a new chemical mechanism in non-heme metallomonooxygenases.
Biochemistry 1994;33(1):226-34.
1994: Klinman J P; Mu D
Quinoenzymes in biology.
Annual review of biochemistry 1994;63():299-344.
1993: Bahnson B J; Park D H; Kim K; Plapp B V; Klinman J P
Unmasking of hydrogen tunneling in the horse liver alcohol dehydrogenase reaction by site-directed mutagenesis.
Biochemistry 1993;32(21):5503-7.
1993: Hartmann C; Brzovic P; Klinman J P
Spectroscopic detection of chemical intermediates in the reaction of para-substituted benzylamines with bovine serum amine oxidase.
Biochemistry 1993;32(9):2234-41.
1992: Janes S M; Palcic M M; Scaman C H; Smith A J; Brown D E; Dooley D M; Mure M; Klinman J P
Identification of topaquinone and its consensus sequence in copper amine oxidases.
Biochemistry 1992;31(48):12147-54.
1992: Rucker J; Cha Y; Jonsson T; Grant K L; Klinman J P
Role of internal thermodynamics in determining hydrogen tunneling in enzyme-catalyzed hydrogen transfer reactions.
Biochemistry 1992;31(46):11489-99.
1992: Mu D; Janes S M; Smith A J; Brown D E; Dooley D M; Klinman J P
Tyrosine codon corresponds to topa quinone at the active site of copper amine oxidases.
The Journal of biological chemistry 1992;267(12):7979-82.
1991: Kim S C; Klinman J P
Mechanism of inhibition of dopamine beta-monooxygenase by quinol and phenol derivatives, as determined by solvent and substrate deuterium isotope effects.
Biochemistry 1991;30(33):8138-44.
1991: Huyghe B G; Klinman J P
Activity of membranous dopamine beta-monooxygenase within chromaffin granule ghosts. Interaction with ascorbate.
The Journal of biological chemistry 1991;266(18):11544-50.
1991: Stewart L C; Klinman J P
Cooperativity in the dopamine beta-monooxygenase reaction. Evidence for ascorbate regulation of enzyme activity.
The Journal of biological chemistry 1991;266(18):11537-43.
1991: Janes S M; Klinman J P
An investigation of bovine serum amine oxidase active site stoichiometry: evidence for an aminotransferase mechanism involving two carbonyl cofactors per enzyme dimer.
Biochemistry 1991;30(18):4599-605.
1991: Hartmann C; Klinman J P
Structure-function studies of substrate oxidation by bovine serum amine oxidase: relationship to cofactor structure and mechanism.
Biochemistry 1991;30(18):4605-11.
1991: Klinman J P; Dooley D M; Duine J A; Knowles P F; Mondovi B; Villafranca J J
Status of the cofactor identity in copper oxidative enzymes.
FEBS letters 1991;282(1):1-4.
1991: Brown D E; McGuirl M A; Dooley D M; Janes S M; Mu D; Klinman J P
The organic functional group in copper-containing amine oxidases. Resonance Raman spectra are consistent with the presence of topa quinone (6-hydroxydopa quinone) in the active site.
The Journal of biological chemistry 1991;266(7):4049-51.
1990: Janes S M; Mu D; Wemmer D; Smith A J; Kaur S; Maltby D; Burlingame A L; Klinman J P
A new redox cofactor in eukaryotic enzymes: 6-hydroxydopa at the active site of bovine serum amine oxidase.
Science (New York, N.Y.) 1990;248(4958):981-7.
1990: Bossard M J; Klinman J P
Use of isotope effects to characterize intermediates in mechanism-based inactivation of dopamine beta-monooxygenase by beta-chlorophenethylamine.
The Journal of biological chemistry 1990;265(10):5640-7.
1990: Hartmann C; Klinman J P
Reductive trapping of substrate to methylamine oxidase from Arthrobacter P1.
FEBS letters 1990;261(2):441-4.
1989: Taljanidisz J; Stewart L; Smith A J; Klinman J P
Structure of bovine adrenal dopamine beta-monooxygenase, as deduced from cDNA and protein sequencing: evidence that the membrane-bound form of the enzyme is anchored by an uncleaved signal peptide.
Biochemistry 1989;28(26):10054-61.
1989: Klinman J P
Quantum mechanical effects in enzyme-catalysed hydrogen transfer reactions.
Trends in biochemical sciences 1989;14(9):368-73.
1989: Grant K L; Klinman J P
Evidence that both protium and deuterium undergo significant tunneling in the reaction catalyzed by bovine serum amine oxidase.
Biochemistry 1989;28(16):6597-605.
1989: Ahn N G; Klinman J P
Nature of rate-limiting steps in a compartmentalized enzyme system. Quantitation of dopamine transport and hydroxylation rates in resealed chromaffin granule ghosts.
The Journal of biological chemistry 1989;264(21):12259-65.
1989: Brenner M C; Klinman J P
Correlation of copper valency with product formation in single turnovers of dopamine beta-monooxygenase.
Biochemistry 1989;28(11):4664-70.
1989: Brenner M C; Murray C J; Klinman J P
Rapid freeze- and chemical-quench studies of dopamine beta-monooxygenase: comparison of pre-steady-state and steady-state parameters.
Biochemistry 1989;28(11):4656-64.
1989: Cha Y; Murray C J; Klinman J P
Hydrogen tunneling in enzyme reactions.
Science (New York, N.Y.) 1989;243(4896):1325-30.
1988: Klinman J P; Janes S; Hartmann C
Mechanism of reaction of the copper amine oxidases.
Pharmacological research communications 1988;20 Suppl 4():35-7.
1988: Stewart L C; Klinman J P
Bovine membranous dopamine beta-hydroxylase is not anchored via covalently attached phosphatidylinositol.
The Journal of biological chemistry 1988;263(25):12183-6.
1988: Hartmann C; Klinman J P
Pyrroloquinoline quinone: a new redox cofactor in eukaryotic enzymes.
BioFactors (Oxford, England) 1988;1(1):41-9.
1988: Stewart L C; Klinman J P
Dopamine beta-hydroxylase of adrenal chromaffin granules: structure and function.
Annual review of biochemistry 1988;57():551-92.
1988: Klinman J P; Brenner M
Role of copper and catalytic mechanism in the copper monooxygenase, dopamine beta-hydroxylase (D beta H).
Progress in clinical and biological research 1988;274():227-48.
1987: Stewart L C; Klinman J P
Characterization of alternate reductant binding and electron transfer in the dopamine beta-monooxygenase reaction.
Biochemistry 1987;26(17):5302-9.
1987: Ahn N G; Klinman J P
Activation of dopamine beta-monooxygenase by external and internal electron donors in resealed chromaffin granule ghosts.
The Journal of biological chemistry 1987;262(4):1485-92.
1987: Hartmann C; Klinman J P
Reductive trapping of substrate to bovine plasma amine oxidase.
The Journal of biological chemistry 1987;262(3):962-5.
1986: Bossard M J; Klinman J P
Mechanism-based inhibition of dopamine beta-monooxygenase by aldehydes and amides.
The Journal of biological chemistry 1986;261(35):16421-7.
1986: Farnum M F; Klinman J P
Stereochemical probes of bovine plasma amine oxidase: evidence for mirror image processing and a syn abstraction of hydrogens from C-1 and C-2 of dopamine.
Biochemistry 1986;25(20):6028-36.
1986: Farnum M; Palcic M; Klinman J P
pH dependence of deuterium isotope effects and tritium exchange in the bovine plasma amine oxidase reaction: a role for single-base catalysis in amine oxidation and imine exchange.
Biochemistry 1986;25(8):1898-904.
1985: Miller S M; Klinman J P
Secondary isotope effects and structure-reactivity correlations in the dopamine beta-monooxygenase reaction: evidence for a chemical mechanism.
Biochemistry 1985;24(9):2114-27.
1984: Mangold J B; Klinman J P
Mechanism-based inactivation of dopamine beta-monooxygenase by beta-chlorophenethylamine.
The Journal of biological chemistry 1984;259(12):7772-9.
1984: Klinman J P; Krueger M; Brenner M; Edmondson D E
Evidence for two copper atoms/subunit in dopamine beta-monooxygenase catalysis.
The Journal of biological chemistry 1984;259(6):3399-402.
1983: Palcic M M; Klinman J P
Isotopic probes yield microscopic constants: separation of binding energy from catalytic efficiency in the bovine plasma amine oxidase reaction.
Biochemistry 1983;22(25):5957-66.
1983: Ahn N; Klinman J P
Mechanism of modulation of dopamine beta-monooxygenase by pH and fumarate as deduced from initial rate and primary deuterium isotope effect studies.
Biochemistry 1983;22(13):3096-106.
1983: Miller S M; Klinman J P
Magnitude of intrinsic isotope effects in the dopamine beta-monooxygenase reaction.
Biochemistry 1983;22(13):3091-6.
1982: Klinman J P; Krueger M
Dopamine beta-hydroxylase: activity and inhibition in the presence of beta-substituted phenethylamines.
Biochemistry 1982;21(1):67-75.
1982: Miller S M; Klinman J P
Deduction of kinetic mechanisms from primary hydrogen isotope effects: dopamine beta-monooxygenase--a case history.
Methods in enzymology 1982;87():711-32.
1981: Allen R R; Klinman J P
Stereochemistry and kinetic isotope effects in the decarboxylation of S-adenosylmethionine catalyzed by the pyruvyl enzyme, S-adenosylmethionine decarboxylase.
The Journal of biological chemistry 1981;256(7):3233-9.
1981: Klinman J P
Probes of mechanism and transition-state structure in the alcohol dehydrogenase reaction.
CRC critical reviews in biochemistry 1981;10(1):39-78.
1980: Klinman J P; Humphries H; Voet J G
Deduction of kinetic mechanism in multisubstrate enzyme reactions from tritium isotope effects. Application to dopamine beta-hydroxylase.
The Journal of biological chemistry 1980;255(24):11648-51.
1980: Welsh K M; Creighton D J; Klinman J P
Transition-state structure in the yeast alcohol dehydrogenase reaction: the magnitude of solvent and alpha-secondary hydrogen isotope effects.
Biochemistry 1980;19(10):2005-16.

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