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Amira Klip

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Cesar Osorio-Fuentealba; Francisco Altamirano; Ariel E Contreras-Ferrat; Alejandra Espinosa; Amira Klip; Sergio Lavandero; Qing Li; Wenyan Niu; Enrique Jaimovich
Electrical Stimuli Release ATP to Increase GLUT4 Translocation and Glucose Uptake via PI3Kγ-Akt-AS160 in Skeletal Muscle Cells.
Lykke Sylow; Peter Schjerling; Shlomit Boguslavsky; Tim T Chiu; Thomas E Jensen; Jacob Jeppesen; Maximilian Kleinert; Amira Klip; Stine J Maarbjerg; Joshua R Mouatt; Clara Prats; Erik A Richter
Rac1 is a novel regulator of contraction-stimulated glucose uptake in skeletal muscle.
Nicolas J. Pillon; Philip J Bilan; Lisbeth N Fink; Amira Klip
Cross-talk between skeletal muscle and immune cells: muscle-derived mediators and metabolic implications.

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2013: Cesar Osorio-Fuentealba; Francisco Altamirano; Ariel E Contreras-Ferrat; Alejandra Espinosa; Amira Klip; Sergio Lavandero; Qing Li; Wenyan Niu; Enrique Jaimovich
Electrical Stimuli Release ATP to Increase GLUT4 Translocation and Glucose Uptake via PI3Kγ-Akt-AS160 in Skeletal Muscle Cells.
Diabetes 2013;62(5):1519-26.
2013: Lykke Sylow; Peter Schjerling; Shlomit Boguslavsky; Tim T Chiu; Thomas E Jensen; Jacob Jeppesen; Maximilian Kleinert; Amira Klip; Stine J Maarbjerg; Joshua R Mouatt; Clara Prats; Erik A Richter
Rac1 is a novel regulator of contraction-stimulated glucose uptake in skeletal muscle.
Diabetes 2013;62(4):1139-51.
2013: Nicolas J. Pillon; Philip J Bilan; Lisbeth N Fink; Amira Klip
Cross-talk between skeletal muscle and immune cells: muscle-derived mediators and metabolic implications.
American journal of physiology. Endocrinology and metabolism 2013;304(5):E453-65.
2013: Yi Zhu; Olesya Ilkun; Amira Klip; Brian T O'Neill; Renata Oliveira Pereira; Tenley A Rawlings; Christian Riehle; Ichiro Shiojima; Kenneth Walsh; Adam R Wende; Quanjiang Zhang; Yi Cheng Zhang; E Dale Abel
Cardiac PI3K-Akt impairs insulin-stimulated glucose uptake independent of mTORC1 and GLUT4 translocation.
Molecular endocrinology (Baltimore, Md.) 2013;27(1):172-84.
2013: Sophie E Hussey; Amira Klip; Hanyu Liang; Sheila R Costford; Ralph A DeFronzo; Brian Ely; Alicia Sanchez-Avila; Nicolas Musi
TAK-242, a small-molecule inhibitor of Toll-like receptor 4 signalling, unveils similarities and differences in lipopolysaccharide- and lipid-induced inflammation and insulin resistance in muscle cells.
Bioscience reports 2013;33(1):37-47.
2012: Warren L Lee; Amira Klip
Shuttling glucose across brain microvessels, with a little help from GLUT1 and AMP kinase. Focus on "AMP kinase regulation of sugar transport in brain capillary endothelial cells during acute metabolic stress".
American journal of physiology. Cell physiology 2012;303(8):C803-5.
2012: Shlomit Boguslavsky; Tim Chiu; Kevin P Foley; Costin N Antonescu; K Ulrich Bayer; Philip J Bilan; Cesar Osorio-Fuentealba; Amira Klip
Myo1c binding to submembrane actin mediates insulin-induced tethering of GLUT4 vesicles.
Molecular biology of the cell 2012;23(20):4065-78.
2012: Silvania Silva Teixeira; Francemilson Goulart-Silva; Amira Klip; Caroline Serrano-Nascimento; Akhilesh K Tamrakar; Maria Tereza Nunes
Triiodothyronine acutely stimulates glucose transport into L6 muscle cells without increasing surface GLUT4, GLUT1, or GLUT3.
Thyroid : official journal of the American Thyroid Association 2012;22(7):747-54.
2012: Nicolas J. Pillon; Karen Arane; Philip J Bilan; Tim T Chiu; Amira Klip
Muscle cells challenged with saturated fatty acids mount an autonomous inflammatory response that activates macrophages.
Cell communication and signaling : CCS 2012;10(1):30.
2011: Junna Yu; Philip J Bilan; Qing He; Amira Klip; M Constantine Samaan; Lihuan Shi; Hui Wang; Zhi Yao; Wenyan Niu
Conditioned medium from hypoxia-treated adipocytes renders muscle cells insulin resistant.
European journal of cell biology 2011;90(12):1000-15.
2011: Jonathan D Schertzer; Amira Klip
Give a NOD to insulin resistance.
American journal of physiology. Endocrinology and metabolism 2011;301(4):E585-6.
2011: Jonathan D Schertzer; Gregory R Steinberg; Akhilesh K Tamrakar; Philip J Bilan; Morgan D Fullerton; Adria Giacca; Zhi Liu; Joao G Magalhães; Sandra Pereira; Dana J Philpott; Amira Klip
NOD1 activators link innate immunity to insulin resistance.
Diabetes 2011;60(9):2206-15.
2011: Kevin Foley; Shlomit Boguslavsky; Amira Klip
Endocytosis, recycling, and regulated exocytosis of glucose transporter 4.
Biochemistry 2011;50(15):3048-61.
2011: Girish Kewalramani; Farzad Asadi; Lisbeth Nielsen Fink; Amira Klip
Palmitate-activated macrophages confer insulin resistance to muscle cells by a mechanism involving protein kinase C θ and ε.
PloS one 2011;6(10):e26947.
2011: Wenyan Niu; Philip J Bilan; Junna Yu; Jing Gao; Shlomit Boguslavsky; Jonathan D Schertzer; Guilan Chu; Zhi Yao; Amira Klip
PKCε regulates contraction-stimulated GLUT4 traffic in skeletal muscle cells.
Journal of cellular physiology 2011;226(1):173-80.
2010: Akhilesh K Tamrakar; Jonathan D Schertzer; Tim T Chiu; Kevin P Foley; Philip J Bilan; Dana J Philpott; Amira Klip
NOD2 activation induces muscle cell-autonomous innate immune responses and insulin resistance.
Endocrinology 2010;151(12):5624-37.
2010: Yi Sun; Philip J Bilan; Zhi Liu; Amira Klip
Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(46):19909-14.
2010: Tim Ting Chiu; Nish Patel; Alisa E Shaw; James R Bamburg; Amira Klip
Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cells.
Molecular biology of the cell 2010;21(20):3529-39.
2010: A E Contreras-Ferrat; B Toro; R Bravo; V Parra; C Vásquez; C Ibarra; D Mears; Mario Chiong; E Jaimovich; Amira Klip; Sergio Lavandero
An inositol 1,4,5-triphosphate (IP3)-IP3 receptor pathway is required for insulin-stimulated glucose transporter 4 translocation and glucose uptake in cardiomyocytes.
Endocrinology 2010;151(10):4665-77.
2010: Girish Kewalramani; Philip J Bilan; Amira Klip
Muscle insulin resistance: assault by lipids, cytokines and local macrophages.
Current opinion in clinical nutrition and metabolic care 2010;13(4):382-90.
2010: Wenyan Niu; Philip J Bilan; Shuhei Ishikura; Jonathan D Schertzer; Ariel Contreras-Ferrat; Zhengxiang Fu; Jie Liu; Shlomit Boguslavsky; Kevin P Foley; Zhi Liu; Jinru Li; Guilan Chu; Thomas Panakkezhum; Gary D Lopaschuk; Sergio Lavandero; Zhi Yao; Amira Klip
Contraction-related stimuli regulate GLUT4 traffic in C2C12-GLUT4myc skeletal muscle cells.
American journal of physiology. Endocrinology and metabolism 2010;298(5):E1058-71.
2010: Shuhei Ishikura; Costin N Antonescu; Amira Klip
Documenting GLUT4 exocytosis and endocytosis in muscle cell monolayers.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2010;Chapter 15():Unit 15.15.
2010: Alaa Badawi; Amira Klip; Pierre Haddad; David Ec Cole; Bibiana Garcia Bailo; Ahmed El-Sohemy; Mohamed Karmali
Type 2 diabetes mellitus and inflammation: Prospects for biomarkers of risk and nutritional intervention.
Diabetes, metabolic syndrome and obesity : targets and therapy 2010;3():173-86.
2009: Philip J Bilan; Victor Samokhvalov; Alexandra Koshkina; Jonathan D Schertzer; M Constantine Samaan; Amira Klip
Direct and macrophage-mediated actions of fatty acids causing insulin resistance in muscle cells.
Archives of physiology and biochemistry 2009;115(4):176-90.
2009: Sean M Hartig; Shuhei Ishikura; Rachel S Hicklen; Yanming Feng; Elisabeth G Blanchard; Kevin A Voelker; Christina S Pichot; Robert W Grange; Robert M Raphael; Amira Klip; Seth J Corey
The F-BAR protein CIP4 promotes GLUT4 endocytosis through bidirectional interactions with N-WASp and Dynamin-2.
Journal of cell science 2009;122(Pt 13):2283-91.
2009: Aaron D Schimmer; David Malkin; Eldad Zackenhaus; Allan Kagal; Amira Klip; Daniela Rotin; Mark D Minden; Jerome Teitel
Health care crisis in Gaza.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2009;180(12):1230.
2009: Amira Klip
The many ways to regulate glucose transporter 4.
Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme 2009;34(3):481-7.
2009: Amira Klip; J D Schertzer; Philip J Bilan; Farah S L Thong; C Antonescu
Regulation of glucose transporter 4 traffic by energy deprivation from mitochondrial compromise.
Acta physiologica (Oxford, England) 2009;196(1):27-35.
2009: Hilal Zaid; Ilana Talior-Volodarsky; Costin Antonescu; Zhi Liu; Amira Klip
GAPDH binds GLUT4 reciprocally to hexokinase-II and regulates glucose transport activity.
The Biochemical journal 2009;419(2):475-84.
2009: Jonathan D Schertzer; Costin N Antonescu; Philip J Bilan; Swati Jain; Xudong Huang; Zhi Liu; Arend Bonen; Amira Klip
A transgenic mouse model to study glucose transporter 4myc regulation in skeletal muscle.
Endocrinology 2009;150(4):1935-40.
2009: Costin N Antonescu; Michelangelo Foti; Nathalie Sauvonnet; Amira Klip
Ready, set, internalize: mechanisms and regulation of GLUT4 endocytosis.
Bioscience reports 2009;29(1):1-11.
2009: Victor Samokhvalov; Philip J Bilan; Jonathan D Schertzer; Costin N Antonescu; Amira Klip
Palmitate- and lipopolysaccharide-activated macrophages evoke contrasting insulin responses in muscle cells.
American journal of physiology. Endocrinology and metabolism 2009;296(1):E37-46.
2008: Tabitha E Wood; Shadi Dalili; Craig D Simpson; Rose Hurren; Xinliang Mao; Fernando Suarez Saiz; Marcela Gronda; Yanina Eberhard; Mark D Minden; Philip J Bilan; Amira Klip; Robert A Batey; Aaron D Schimmer
A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death.
Molecular cancer therapeutics 2008;7(11):3546-55.
2008: Varinder K Randhawa; Shuhei Ishikura; Ilana Talior-Volodarsky; Alex W P Cheng; Nish Patel; John H Hartwig; Amira Klip
GLUT4 vesicle recruitment and fusion are differentially regulated by Rac, AS160, and Rab8A in muscle cells.
The Journal of biological chemistry 2008;283(40):27208-19.
2008: Shuhei Ishikura; Amira Klip
Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocation.
American journal of physiology. Cell physiology 2008;295(4):C1016-25.
2008: Ilana Talior-Volodarsky; Varinder K Randhawa; Hilal Zaid; Amira Klip
Alpha-actinin-4 is selectively required for insulin-induced GLUT4 translocation.
The Journal of biological chemistry 2008;283(37):25115-23.
2008: Hilal Zaid; Costin N Antonescu; Varinder K Randhawa; Amira Klip
Insulin action on glucose transporters through molecular switches, tracks and tethers.
The Biochemical journal 2008;413(2):201-15.
2008: Costin N Antonescu; Mònica Díaz; Guiseppe Femia; Josep V Planas; Amira Klip
Clathrin-dependent and independent endocytosis of glucose transporter 4 (GLUT4) in myoblasts: regulation by mitochondrial uncoupling.
Traffic (Copenhagen, Denmark) 2008;9(7):1173-90.
2008: Chandrasagar B Dugani; Varinder K Randhawa; Alex W P Cheng; Nish Patel; Amira Klip
Selective regulation of the perinuclear distribution of glucose transporter 4 (GLUT4) by insulin signals in muscle cells.
European journal of cell biology 2008;87(6):337-51.
2008: Nerea Roher; Victor Samokhvalov; Mònica Díaz; SImon MacKenzie; Amira Klip; Josep V Planas
The proinflammatory cytokine tumor necrosis factor-alpha increases the amount of glucose transporter-4 at the surface of muscle cells independently of changes in interleukin-6.
Endocrinology 2008;149(4):1880-9.
2008: Costin N Antonescu; Varinder K Randhawa; Amira Klip
Dissecting GLUT4 traffic components in L6 myocytes by fluorescence-based, single-cell assays.
Methods in molecular biology (Clifton, N.J.) 2008;457():367-78.
2008: Amira Klip
Kei on GSK: a contribution by the 2007 recipient of the Young Scientist Award.
American journal of physiology. Endocrinology and metabolism 2008;294(1):E27.
2007: Mònica Díaz; Costin N Antonescu; Encarnación Capilla; Amira Klip; Josep V Planas
Fish glucose transporter (GLUT)-4 differs from rat GLUT4 in its traffic characteristics but can translocate to the cell surface in response to insulin in skeletal muscle cells.
Endocrinology 2007;148(11):5248-57.
2007: Shuhei Ishikura; Philip J Bilan; Amira Klip
Rabs 8A and 14 are targets of the insulin-regulated Rab-GAP AS160 regulating GLUT4 traffic in muscle cells.
Biochemical and biophysical research communications 2007;353(4):1074-9.
2007: Farah S L Thong; Philip J Bilan; Amira Klip
The Rab GTPase-activating protein AS160 integrates Akt, protein kinase C, and AMP-activated protein kinase signals regulating GLUT4 traffic.
Diabetes 2007;56(2):414-23.
2007: Lellean JeBailey; Oshrit Wanono; Wenyan Niu; Jessica Roessler; Assaf Rudich; Amira Klip
Ceramide- and oxidant-induced insulin resistance involve loss of insulin-dependent Rac-activation and actin remodeling in muscle cells.
Diabetes 2007;56(2):394-403.
2006: Amira Klip; Mladen Vranic
Muscle, liver, and pancreas: Three Musketeers fighting to control glycemia.
American journal of physiology. Endocrinology and metabolism 2006;291(6):E1141-3.
2006: Nadeeja Wijesekara; Amanda Tung; Farah S L Thong; Amira Klip
Muscle cell depolarization induces a gain in surface GLUT4 via reduced endocytosis independently of AMPK.
American journal of physiology. Endocrinology and metabolism 2006;290(6):E1276-86.
2006: Ana C P Thirone; Lellean JeBailey; Philip J Bilan; Amira Klip
Opposite effect of JAK2 on insulin-dependent activation of mitogen-activated protein kinases and Akt in muscle cells: possible target to ameliorate insulin resistance.
Diabetes 2006;55(4):942-51.
2006: Ana C P Thirone; Carol Huang; Amira Klip
Tissue-specific roles of IRS proteins in insulin signaling and glucose transport.
Trends in endocrinology and metabolism: TEM 2006;17(2):72-8.
2006: Leonard J Foster; Assaf Rudich; Ilana Talior; Nish Patel; Xudong Huang; L Michelle Furtado; Philip J Bilan; Matthias Mann; Amira Klip
Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC).
Journal of proteome research 2006;5(1):64-75.
2006: Nish Patel; Carol Huang; Amira Klip
Cellular location of insulin-triggered signals and implications for glucose uptake.
Pflügers Archiv : European journal of physiology 2006;451(4):499-510.
2005: Amira Klip; Meredith Hawkins
Desperately seeking sugar: glial cells as hypoglycemia sensors.
The Journal of clinical investigation 2005;115(12):3403-5.
2005: Chandrasagar B Dugani; Amira Klip
Glucose transporter 4: cycling, compartments and controversies.
EMBO reports 2005;6(12):1137-42.
2005: Manabu Ishiki; Amira Klip
Minireview: recent developments in the regulation of glucose transporter-4 traffic: new signals, locations, and partners.
Endocrinology 2005;146(12):5071-8.
2005: Costin N Antonescu; Carol Huang; Wenyan Niu; Zhi Liu; P A Eyers; K A Heidenreich; Philip J Bilan; Amira Klip
Reduction of insulin-stimulated glucose uptake in L6 myotubes by the protein kinase inhibitor SB203580 is independent of p38MAPK activity.
Endocrinology 2005;146(9):3773-81.
2005: Manabu Ishiki; Varinder K Randhawa; Vincent Poon; Lellean JeBailey; Amira Klip
Insulin regulates the membrane arrival, fusion, and C-terminal unmasking of glucose transporter-4 via distinct phosphoinositides.
The Journal of biological chemistry 2005;280(31):28792-802.
2005: Farah S L Thong; Chandrasagar B Dugani; Amira Klip
Turning signals on and off: GLUT4 traffic in the insulin-signaling highway.
Physiology (Bethesda, Md.) 2005;20():271-84.
2005: Carol Huang; Ana C P Thirone; Xudong Huang; Amira Klip
Differential contribution of insulin receptor substrates 1 versus 2 to insulin signaling and glucose uptake in l6 myotubes.
The Journal of biological chemistry 2005;280(19):19426-35.
2005: Daniel Konrad; Assaf Rudich; Philip J Bilan; Nish Patel; C Richardson; L A Witters; Amira Klip
Troglitazone causes acute mitochondrial membrane depolarisation and an AMPK-mediated increase in glucose phosphorylation in muscle cells.
Diabetologia 2005;48(5):954-66.
2005: Nadeeja Wijesekara; Daniel Konrad; Mohamed Eweida; Craig Jefferies; Nicole Liadis; Adria Giacca; Michael A Crackower; Akira Suzuki; Tak W Mak; C Ronald Kahn; Amira Klip; Minna Woo
Muscle-specific Pten deletion protects against insulin resistance and diabetes.
Molecular and cellular biology 2005;25(3):1135-45.
2004: Varinder K Randhawa; Farah S L Thong; Dawn Y Lim; Dailin Li; Rami R Garg; Rachel Rudge; Thierry Galli; Assaf Rudich; Amira Klip
Insulin and hypertonicity recruit GLUT4 to the plasma membrane of muscle cells by using N-ethylmaleimide-sensitive factor-dependent SNARE mechanisms but different v-SNAREs: role of TI-VAMP.
Molecular biology of the cell 2004;15(12):5565-73.
2004: Dóra Török; Nish Patel; Lellean JeBailey; Farah S L Thong; Varinder K Randhawa; Amira Klip; Assaf Rudich
Insulin but not PDGF relies on actin remodeling and on VAMP2 for GLUT4 translocation in myoblasts.
Journal of cell science 2004;117(Pt 22):5447-55.
2004: Gary Sweeney; Rami R Garg; Rolando B Ceddia; Dailin Li; Manabu Ishiki; Romel Somwar; Leonard J Foster; Paul O Neilsen; Glenn D Prestwich; Assaf Rudich; Amira Klip
Intracellular delivery of phosphatidylinositol (3,4,5)-trisphosphate causes incorporation of glucose transporter 4 into the plasma membrane of muscle and fat cells without increasing glucose uptake.
The Journal of biological chemistry 2004;279(31):32233-42.
2004: Lellean JeBailey; Assaf Rudich; Xudong Huang; Caterina Di Ciano-Oliveira; Andras Kapus; Amira Klip
Skeletal muscle cells and adipocytes differ in their reliance on TC10 and Rac for insulin-induced actin remodeling.
Molecular endocrinology (Baltimore, Md.) 2004;18(2):359-72.
2004: Amira Klip
Intracellular traffic and activation of the muscle glucose transporter.
Journal of muscle research and cell motility 2004;25(8):595-6.
2003: Kathleen Lemieux; Daniel Konrad; Amira Klip; André Marette
The AMP-activated protein kinase activator AICAR does not induce GLUT4 translocation to transverse tubules but stimulates glucose uptake and p38 mitogen-activated protein kinases alpha and beta in skeletal muscle.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(12):1658-65.
2003: Assaf Rudich; Amira Klip
Push/pull mechanisms of GLUT4 traffic in muscle cells.
Acta physiologica Scandinavica 2003;178(4):297-308.
2003: L Michelle Furtado; V Poon; Amira Klip
GLUT4 activation: thoughts on possible mechanisms.
Acta physiologica Scandinavica 2003;178(4):287-96.
2003: Nish Patel; Assaf Rudich; Zayna A Khayat; Rami Garg; Amira Klip
Intracellular segregation of phosphatidylinositol-3,4,5-trisphosphate by insulin-dependent actin remodeling in L6 skeletal muscle cells.
Molecular and cellular biology 2003;23(13):4611-26.
2003: Wenyan Niu; Carol Huang; Zafar Nawaz; Michelle Levy; Romel Somwar; Dailin Li; Philip J Bilan; Amira Klip
Maturation of the regulation of GLUT4 activity by p38 MAPK during L6 cell myogenesis.
The Journal of biological chemistry 2003;278(20):17953-62.
2003: Assaf Rudich; Daniel Konrad; Dóra Török; Ronit Ben-Romano; Carol Huang; Wenyan Niu; Rami R Garg; Nadeeja Wijesekara; R J Germinario; Philip J Bilan; Amira Klip
Indinavir uncovers different contributions of GLUT4 and GLUT1 towards glucose uptake in muscle and fat cells and tissues.
Diabetologia 2003;46(5):649-58.
2003: Ronit Ben-Romano; Assaf Rudich; Dóra Török; Sharon Vanounou; Klaris Riesenberg; Francisc Schlaeffer; Amira Klip; Nava Bashan
Agent and cell-type specificity in the induction of insulin resistance by HIV protease inhibitors.
AIDS (London, England) 2003;17(1):23-32.
2002: Romel Somwar; Sandra Koterski; Gary Sweeney; Richard Sciotti; Stevan W Djuric; Cathy Berg; James M Trevillyan; Philipp E Scherer; cristina Rondinone; Amira Klip
A dominant-negative p38 MAPK mutant and novel selective inhibitors of p38 MAPK reduce insulin-stimulated glucose uptake in 3T3-L1 adipocytes without affecting GLUT4 translocation.
The Journal of biological chemistry 2002;277(52):50386-95.
2002: Janet Farhang-Fallah; Varinder K Randhawa; Anjaruwee Nimnual; Amira Klip; Dafna Bar-Sagi; Maria Rozakis-Adcock
The pleckstrin homology (PH) domain-interacting protein couples the insulin receptor substrate 1 PH domain to insulin signaling pathways leading to mitogenesis and GLUT4 translocation.
Molecular and cellular biology 2002;22(20):7325-36.
2002: Daniel Konrad; Philip J Bilan; Zafar Nawaz; Gary Sweeney; Wenyan Niu; Zhi Liu; Costin N Antonescu; Assaf Rudich; Amira Klip
Need for GLUT4 activation to reach maximum effect of insulin-mediated glucose uptake in brown adipocytes isolated from GLUT4myc-expressing mice.
Diabetes 2002;51(9):2719-26.
2002: Carol Huang; Romel Somwar; Nish Patel; Wenyan Niu; Dóra Török; Amira Klip
Sustained exposure of L6 myotubes to high glucose and insulin decreases insulin-stimulated GLUT4 translocation but upregulates GLUT4 activity.
Diabetes 2002;51(7):2090-8.
2002: Zayna A Khayat; Nish Patel; Amira Klip
Exercise- and insulin-stimulated muscle glucose transport: distinct mechanisms of regulation.
Canadian journal of applied physiology = Revue canadienne de physiologie appliquée 2002;27(2):129-51.
2002: L Michelle Furtado; Romel Somwar; Gary Sweeney; Wenyan Niu; Amira Klip
Activation of the glucose transporter GLUT4 by insulin.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2002;80(5):569-78.
2001: Romel Somwar; Wenyan Niu; DY Kim; Gary Sweeney; Varinder K Randhawa; Carol Huang; T Ramlal; Amira Klip
Differential effects of phosphatidylinositol 3-kinase inhibition on intracellular signals regulating GLUT4 translocation and glucose transport.
The Journal of biological chemistry 2001;276(49):46079-87.
2001: Gary Sweeney; W Niu; Victor A Canfield; R Levenson; Amira Klip
Insulin increases plasma membrane content and reduces phosphorylation of Na(+)-K(+) pump alpha(1)-subunit in HEK-293 cells.
American journal of physiology. Cell physiology 2001;281(6):C1797-803.
2001: LJ Foster; Dailin Li; Varinder K Randhawa; Amira Klip
Insulin accelerates inter-endosomal GLUT4 traffic via phosphatidylinositol 3-kinase and protein kinase B.
The Journal of biological chemistry 2001;276(47):44212-21.
2001: Romel Somwar; DY Kim; Gary Sweeney; Carol Huang; Wenyan Niu; C Lador; T Ramlal; Amira Klip
GLUT4 translocation precedes the stimulation of glucose uptake by insulin in muscle cells: potential activation of GLUT4 via p38 mitogen-activated protein kinase.
The Biochemical journal 2001;359(Pt 3):639-49.
2001: Gary Sweeney; J Keen; Romel Somwar; Daniel Konrad; R Garg; Amira Klip
High leptin levels acutely inhibit insulin-stimulated glucose uptake without affecting glucose transporter 4 translocation in l6 rat skeletal muscle cells.
Endocrinology 2001;142(11):4806-12.
2001: ML Weir; H Xie; Amira Klip; William S Trimble
VAP-A binds promiscuously to both v- and tSNAREs.
Biochemical and biophysical research communications 2001;286(3):616-21.
2001: P Tong; Zayna A Khayat; Carol Huang; Nish Patel; A Ueyama; Amira Klip
Insulin-induced cortical actin remodeling promotes GLUT4 insertion at muscle cell membrane ruffles.
The Journal of clinical investigation 2001;108(3):371-81.
2001: Nish Patel; Zayna A Khayat; N B Ruderman; Amira Klip
Dissociation of 5' AMP-activated protein kinase activation and glucose uptake stimulation by mitochondrial uncoupling and hyperosmolar stress: differential sensitivities to intracellular Ca2+ and protein kinase C inhibition.
Biochemical and biophysical research communications 2001;285(4):1066-70.
2001: Dailin Li; Varinder K Randhawa; Nish Patel; M Hayashi; Amira Klip
Hyperosmolarity reduces GLUT4 endocytosis and increases its exocytosis from a VAMP2-independent pool in l6 muscle cells.
The Journal of biological chemistry 2001;276(25):22883-91.
2001: Daniel Konrad; Romel Somwar; Gary Sweeney; KL Yaworsky; M Hayashi; T Ramlal; Amira Klip
The antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: potential role of p38 mitogen-activated protein kinase in GLUT4 activation.
Diabetes 2001;50(6):1464-71.
2000: Romel Somwar; M Perreault; S Kapur; C Taha; Gary Sweeney; T Ramlal; DY Kim; J Keen; C H Côte; Amira Klip; André Marette
Activation of p38 mitogen-activated protein kinase alpha and beta by insulin and contraction in rat skeletal muscle: potential role in the stimulation of glucose transport.
Diabetes 2000;49(11):1794-800.
2000: LJ Foster; Amira Klip
Mechanism and regulation of GLUT-4 vesicle fusion in muscle and fat cells.
American journal of physiology. Cell physiology 2000;279(4):C877-90.
2000: Varinder K Randhawa; Philip J Bilan; Zayna A Khayat; N Daneman; Zhi Liu; T Ramlal; Allen Volchuk; Xiao-Rong Peng; Thierry Coppola; Romano Regazzi; William S Trimble; Amira Klip
VAMP2, but not VAMP3/cellubrevin, mediates insulin-dependent incorporation of GLUT4 into the plasma membrane of L6 myoblasts.
Molecular biology of the cell 2000;11(7):2403-17.
2000: LJ Foster; ML Weir; D Y Lim; Zhi Liu; William S Trimble; Amira Klip
A functional role for VAP-33 in insulin-stimulated GLUT4 traffic.
Traffic (Copenhagen, Denmark) 2000;1(6):512-21.
2000: KL Yaworsky; Romel Somwar; T Ramlal; H J Tritschler; Amira Klip
Engagement of the insulin-sensitive pathway in the stimulation of glucose transport by alpha-lipoic acid in 3T3-L1 adipocytes.
Diabetologia 2000;43(3):294-303.
2000: Gary Sweeney; Wenyan Niu; Ronik Kanani; Amira Klip
Regulation of the Na,K-pump by leptin in 3T3-L1 fibroblasts.
Endocrinology 2000;141(3):1277-80.
2000: Zayna A Khayat; P Tong; KL Yaworsky; Robert J Bloch; Amira Klip
Insulin-induced actin filament remodeling colocalizes actin with phosphatidylinositol 3-kinase and GLUT4 in L6 myotubes.
Journal of cell science 2000;113 Pt 2():279-90.
1999: C Taha; Zhi Liu; J Jin; H Al-Hasani; N Sonenberg; Amira Klip
Opposite translational control of GLUT1 and GLUT4 glucose transporter mRNAs in response to insulin. Role of mammalian target of rapamycin, protein kinase b, and phosphatidylinositol 3-kinase in GLUT1 mRNA translation.
The Journal of biological chemistry 1999;274(46):33085-91.
1999: Bernardo Yusta; Romel Somwar; F Wang; DG Munroe; Sergio Grinstein; Amira Klip; Daniel J Drucker
Identification of glucagon-like peptide-2 (GLP-2)-activated signaling pathways in baby hamster kidney fibroblasts expressing the rat GLP-2 receptor.
The Journal of biological chemistry 1999;274(43):30459-67.
1999: T Tsakiridis; P Tong; B Matthews; Evangelia Tsiani; Philip J Bilan; Amira Klip; Gregory P Downey
Role of the actin cytoskeleton in insulin action.
Microscopy research and technique 1999;47(2):79-92.
1999: A Ueyama; KL Yaworsky; Q Wang; Y Ebina; Amira Klip
GLUT-4myc ectopic expression in L6 myoblasts generates a GLUT-4-specific pool conferring insulin sensitivity.
The American journal of physiology 1999;277(3 Pt 1):E572-8.
1999: D Li; Gary Sweeney; Q Wang; Amira Klip
Participation of PI3K and atypical PKC in Na+-K+-pump stimulation by IGF-I in VSMC.
The American journal of physiology 1999;276(6 Pt 2):H2109-16.
1999: Julian Mathoo; ZQ Shi; Amira Klip; Mladen Vranic
Opposite effects of acute hypoglycemia and acute hyperglycemia on glucose transport and glucose transporters in perfused rat skeletal muscle.
Diabetes 1999;48(6):1281-8.
1999: Q Wang; Romel Somwar; Philip J Bilan; Zhi Liu; J Jin; James R Woodgett; Amira Klip
Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts.
Molecular and cellular biology 1999;19(6):4008-18.
1999: LJ Foster; KL Yaworsky; William S Trimble; Amira Klip
SNAP23 promotes insulin-dependent glucose uptake in 3T3-L1 adipocytes: possible interaction with cytoskeleton.
The American journal of physiology 1999;276(5 Pt 1):C1108-14.
1999: C Taha; Amira Klip
The insulin signaling pathway.
The Journal of membrane biology 1999;169(1):1-12.
1999: Gary Sweeney; Romel Somwar; T Ramlal; Allen Volchuk; A Ueyama; Amira Klip
An inhibitor of p38 mitogen-activated protein kinase prevents insulin-stimulated glucose transport but not glucose transporter translocation in 3T3-L1 adipocytes and L6 myotubes.
The Journal of biological chemistry 1999;274(15):10071-8.
1998: Zayna A Khayat; T Tsakiridis; A Ueyama; Romel Somwar; Y Ebina; Amira Klip
Rapid stimulation of glucose transport by mitochondrial uncoupling depends in part on cytosolic Ca2+ and cPKC.
The American journal of physiology 1998;275(6 Pt 1):C1487-97.
1998: Q Wang; Philip J Bilan; Amira Klip
Opposite effects of insulin on focal adhesion proteins in 3T3-L1 adipocytes and in cells overexpressing the insulin receptor.
Molecular biology of the cell 1998;9(11):3057-69.
1998: T Tsakiridis; A Bergman; Romel Somwar; C Taha; K Aktories; TF Cruz; Amira Klip; Gregory P Downey
Actin filaments facilitate insulin activation of the src and collagen homologous/mitogen-activated protein kinase pathway leading to DNA synthesis and c-fos expression.
The Journal of biological chemistry 1998;273(43):28322-31.
1998: Steen B Kristiansen; T Ramlal; Amira Klip
Phosphatidylinositol 4-kinase, but not phosphatidylinositol 3-kinase, is present in GLUT4-containing vesicles isolated from rat skeletal muscle.
The Biochemical journal 1998;335 ( Pt 2)():351-6.
1998: Gary Sweeney; Romel Somwar; T Ramlal; P Martin-Vasallo; Amira Klip
Insulin stimulation of K+ uptake in 3T3-L1 fibroblasts involves phosphatidylinositol 3-kinase and protein kinase C-zeta.
Diabetologia 1998;41(10):1199-204.
1998: Romel Somwar; S Sumitani; C Taha; Gary Sweeney; Amira Klip
Temporal activation of p70 S6 kinase and Akt1 by insulin: PI 3-kinase-dependent and -independent mechanisms.
The American journal of physiology 1998;275(4 Pt 1):E618-25.
1998: LJ Foster; B Yeung; Mahmood Mohtashami; K Ross; William S Trimble; Amira Klip
Binary interactions of the SNARE proteins syntaxin-4, SNAP23, and VAMP-2 and their regulation by phosphorylation.
Biochemistry 1998;37(31):11089-96.
1998: Zayna A Khayat; A L McCall; Amira Klip
Unique mechanism of GLUT3 glucose transporter regulation by prolonged energy demand: increased protein half-life.
The Biochemical journal 1998;333 ( Pt 3)():713-8.
1998: ML Weir; Amira Klip; William S Trimble
Identification of a human homologue of the vesicle-associated membrane protein (VAMP)-associated protein of 33 kDa (VAP-33): a broadly expressed protein that binds to VAMP.
The Biochemical journal 1998;333 ( Pt 2)():247-51.
1998: Q Wang; Zayna A Khayat; K Kishi; Y Ebina; Amira Klip
GLUT4 translocation by insulin in intact muscle cells: detection by a fast and quantitative assay.
FEBS letters 1998;427(2):193-7.
1998: Q Wang; Philip J Bilan; T Tsakiridis; Aleksander Hinek; Amira Klip
Actin filaments participate in the relocalization of phosphatidylinositol3-kinase to glucose transporter-containing compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes.
The Biochemical journal 1998;331 ( Pt 3)():917-28.
1998: Allen Volchuk; S Narine; LJ Foster; D Grabs; Pietro De Camilli; Amira Klip
Perturbation of dynamin II with an amphiphysin SH3 domain increases GLUT4 glucose transporters at the plasma membrane in 3T3-L1 adipocytes. Dynamin II participates in GLUT4 endocytosis.
The Journal of biological chemistry 1998;273(14):8169-76.
1998: H S Ewart; Romel Somwar; Amira Klip
Dexamethasone stimulates the expression of GLUT1 and GLUT4 proteins via different signalling pathways in L6 skeletal muscle cells.
FEBS letters 1998;425(1):179-83.
1998: H S Ewart; Romel Somwar; Amira Klip
Dexamethasone stimulates the expression of GLUT1 and GLUT4 proteins via different signalling pathways in L6 skeletal muscle cells.
FEBS letters 1998;421(2):120-4.
1998: Romel Somwar; Gary Sweeney; T Ramlal; Amira Klip
Stimulation of glucose and amino acid transport and activation of the insulin signaling pathways by insulin lispro in L6 skeletal muscle cells.
Clinical therapeutics 1998;20(1):125-40.
1997: Herbert Y Gaisano; Laura Sheu; P P Wong; Amira Klip; William S Trimble
SNAP-23 is located in the basolateral plasma membrane of rat pancreatic acinar cells.
FEBS letters 1997;414(2):298-302.
1997: Juan Carlos Aledo; L Lavoie; Allen Volchuk; S R Keller; Amira Klip; Harinder S Hundal
Identification and characterization of two distinct intracellular GLUT4 pools in rat skeletal muscle: evidence for an endosomal and an insulin-sensitive GLUT4 compartment.
The Biochemical journal 1997;325 ( Pt 3)():727-32.
1997: C Taha; T Tsakiridis; A McCall; Amira Klip
Glucose transporter expression in L6 muscle cells: regulation through insulin- and stress-activated pathways.
The American journal of physiology 1997;273(1 Pt 1):E68-76.
1997: L Lavoie; R Levenson; P Martin-Vasallo; Amira Klip
The molar ratios of alpha and beta subunits of the Na+-K+-ATPase differ in distinct subcellular membranes from rat skeletal muscle.
Biochemistry 1997;36(25):7726-32.
1997: S Sumitani; T Ramlal; Romel Somwar; S R Keller; Amira Klip
Insulin regulation and selective segregation with glucose transporter-4 of the membrane aminopeptidase vp165 in rat skeletal muscle cells.
Endocrinology 1997;138(3):1029-34.
1997: P P Wong; N Daneman; Allen Volchuk; N Lassam; M C Wilson; Amira Klip; William S Trimble
Tissue distribution of SNAP-23 and its subcellular localization in 3T3-L1 cells.
Biochemical and biophysical research communications 1997;230(1):64-8.
1997: T Tsakiridis; Q Wang; C Taha; Sergio Grinstein; G Downey; Amira Klip
Involvement of the actin network in insulin signalling.
Society of General Physiologists series 1997;52():257-71.
1996: D E Estrada; H S Ewart; T Tsakiridis; Allen Volchuk; T Ramlal; H Tritschler; Amira Klip
Stimulation of glucose uptake by the natural coenzyme alpha-lipoic acid/thioctic acid: participation of elements of the insulin signaling pathway.
Diabetes 1996;45(12):1798-804.
1996: T Ramlal; H S Ewart; Romel Somwar; RO Deems; M A Valentin; D A Young; Amira Klip
Muscle subcellular localization and recruitment by insulin of glucose transporters and Na+-K+-ATPase subunits in transgenic mice overexpressing the GLUT4 glucose transporter.
Diabetes 1996;45(11):1516-23.
1996: Juleen R Zierath; L He; A Gumà; E Odegoard Wahlström; Amira Klip; Harriet Wallberg-Henriksson
Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM.
Diabetologia 1996;39(10):1180-9.
1996: T Tsakiridis; C Taha; Sergio Grinstein; Amira Klip
Insulin activates a p21-activated kinase in muscle cells via phosphatidylinositol 3-kinase.
The Journal of biological chemistry 1996;271(33):19664-7.
1996: Allen Volchuk; Q Wang; H S Ewart; Zhi Liu; L He; M K Bennett; Amira Klip
Syntaxin 4 in 3T3-L1 adipocytes: regulation by insulin and participation in insulin-dependent glucose transport.
Molecular biology of the cell 1996;7(7):1075-82.
1996: L Lavoie; D Roy; T Ramlal; Luce Dombrowski; P Martín-Vasallo; André Marette; J L Carpentier; Amira Klip
Insulin-induced translocation of Na+-K+-ATPase subunits to the plasma membrane is muscle fiber type specific.
The American journal of physiology 1996;270(5 Pt 1):C1421-9.
1996: T Tsakiridis; P P Wong; Z Liu; C D Rodgers; Mladen Vranic; Amira Klip
Exercise increases the plasma membrane content of the Na+ -K+ pump and its mRNA in rat skeletal muscles.
Journal of applied physiology (Bethesda, Md. : 1985) 1996;80(2):699-705.
1995: John H Brumell; Allen Volchuk; H Sengelov; Niels Borregaard; A M Cieutat; DF Bainton; Sergio Grinstein; Amira Klip
Subcellular distribution of docking/fusion proteins in neutrophils, secretory cells with multiple exocytic compartments.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(12):5750-9.
1995: Steven J Isakoff; C Taha; E Rose; J Marcusohn; Amira Klip; Edward Y Skolnik
The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(22):10247-51.
1995: C Taha; Y Mitsumoto; Zhi Liu; Edward Y Skolnik; Amira Klip
The insulin-dependent biosynthesis of GLUT1 and GLUT3 glucose transporters in L6 muscle cells is mediated by distinct pathways. Roles of p21ras and pp70 S6 kinase.
The Journal of biological chemistry 1995;270(42):24678-81.
1995: T Tsakiridis; H E McDowell; T Walker; C Peter Downes; Harinder S Hundal; Mladen Vranic; Amira Klip
Multiple roles of phosphatidylinositol 3-kinase in regulation of glucose transport, amino acid transport, and glucose transporters in L6 skeletal muscle cells.
Endocrinology 1995;136(10):4315-22.
1995: S Sumitani; T Ramlal; Zhi Liu; Amira Klip
Expression of syntaxin 4 in rat skeletal muscle and rat skeletal muscle cells in culture.
Biochemical and biophysical research communications 1995;213(2):462-8.
1995: H S Ewart; Amira Klip
Hormonal regulation of the Na(+)-K(+)-ATPase: mechanisms underlying rapid and sustained changes in pump activity.
The American journal of physiology 1995;269(2 Pt 1):C295-311.
1995: C M Wilson; Y Mitsumoto; F Maher; Amira Klip
Regulation of cell surface GLUT1, GLUT3, and GLUT4 by insulin and IGF-I in L6 myotubes.
FEBS letters 1995;368(1):19-22.
1995: R J Sargeant; Zhi Liu; Amira Klip
Action of insulin on Na(+)-K(+)-ATPase and the Na(+)-K(+)-2Cl- cotransporter in 3T3-L1 adipocytes.
The American journal of physiology 1995;269(1 Pt 1):C217-25.
1995: T Tsakiridis; Mladen Vranic; Amira Klip
Phosphatidylinositol 3-kinase and the actin network are not required for the stimulation of glucose transport caused by mitochondrial uncoupling: comparison with insulin action.
The Biochemical journal 1995;309 ( Pt 1)():1-5.
1995: L Lavoie; L He; T Ramlal; Cameron Ackerley; André Marette; Amira Klip
The GLUT4 glucose transporter and the alpha 2 subunit of the Na+,K(+)-ATPase do not localize to the same intracellular vesicles in rat skeletal muscle.
FEBS letters 1995;366(2-3):109-14.
1995: Evangelia Tsiani; T Ramlal; L A Leiter; Amira Klip; I George Fantus
Stimulation of glucose uptake and increased plasma membrane content of glucose transporters in L6 skeletal muscle cells by the sulfonylureas gliclazide and glyburide.
Endocrinology 1995;136(6):2505-12.
1995: Allen Volchuk; R Sargeant; S Sumitani; Zhi Liu; L He; Amira Klip
Cellubrevin is a resident protein of insulin-sensitive GLUT4 glucose transporter vesicles in 3T3-L1 adipocytes.
The Journal of biological chemistry 1995;270(14):8233-40.
1995: A Gumà; Juleen R Zierath; Harriet Wallberg-Henriksson; Amira Klip
Insulin induces translocation of GLUT-4 glucose transporters in human skeletal muscle.
The American journal of physiology 1995;268(4 Pt 1):E613-22.
1994: T Tsakiridis; Mladen Vranic; Amira Klip
Disassembly of the actin network inhibits insulin-dependent stimulation of glucose transport and prevents recruitment of glucose transporters to the plasma membrane.
The Journal of biological chemistry 1994;269(47):29934-42.
1994: Allen Volchuk; Y Mitsumoto; L He; Zhi Liu; E Habermann; William S Trimble; Amira Klip
Expression of vesicle-associated membrane protein 2 (VAMP-2)/synaptobrevin II and cellubrevin in rat skeletal muscle and in a muscle cell line.
The Biochemical journal 1994;304 ( Pt 1)():139-45.
1994: D E Estrada; E Elliott; B Zinman; I Poon; Zhi Liu; Amira Klip; D Daneman
Regulation of glucose transport and expression of GLUT3 transporters in human circulating mononuclear cells: studies in cells from insulin-dependent diabetic and nondiabetic individuals.
Metabolism: clinical and experimental 1994;43(5):591-8.
1994: RO Deems; R W Deacon; T Ramlal; Allen Volchuk; Amira Klip; D A Young
Insulin action on whole body glucose utilization and on muscle glucose transporter translocation in mice.
Biochemical and biophysical research communications 1994;199(2):662-70.
1994: Y Mitsumoto; Zhi Liu; Amira Klip
A long-lasting vitamin C derivative, ascorbic acid 2-phosphate, increases myogenin gene expression and promotes differentiation in L6 muscle cells.
Biochemical and biophysical research communications 1994;199(1):394-402.
1994: Harinder S Hundal; Philip J Bilan; T Tsakiridis; André Marette; Amira Klip
Structural disruption of the trans-Golgi network does not interfere with the acute stimulation of glucose and amino acid uptake by insulin-like growth factor I in muscle cells.
The Biochemical journal 1994;297 ( Pt 2)():289-95.
1994: Amira Klip; T Tsakiridis; André Marette; P A Ortiz
Regulation of expression of glucose transporters by glucose: a review of studies in vivo and in cell cultures.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1994;8(1):43-53.
1993: André Marette; J Krischer; L Lavoie; Cameron Ackerley; J L Carpentier; Amira Klip
Insulin increases the Na(+)-K(+)-ATPase alpha 2-subunit in the surface of rat skeletal muscle: morphological evidence.
The American journal of physiology 1993;265(6 Pt 1):C1716-22.
1993: RR Romanek; R Sargeant; M R Paquet; S Gluck; Amira Klip; Sergio Grinstein
Chloroquine inhibits glucose-transporter recruitment induced by insulin in rat adipocytes independently of its action on endomembrane pH.
The Biochemical journal 1993;296 ( Pt 2)():321-7.
1993: Amira Klip; T Ramlal; Philip J Bilan; André Marette; Zhi Liu; Y Mitsumoto
What signals are involved in the stimulation of glucose transport by insulin in muscle cells?
Cellular signalling 1993;5(5):519-29.
1993: Harinder S Hundal; André Marette; T Ramlal; Z Liu; Amira Klip
Expression of beta subunit isoforms of the Na+,K(+)-ATPase is muscle type-specific.
FEBS letters 1993;328(3):253-8.
1993: André Marette; C Atgié; Zhi Liu; Ludwik J Bukowiecki; Amira Klip
Differential regulation of GLUT1 and GLUT4 glucose transporters in skeletal muscle of a new model of type II diabetes. The obese SHR/N-cp rat.
Diabetes 1993;42(8):1195-201.
1993: R Sargeant; Y Mitsumoto; V Sarabia; G Shillabeer; Amira Klip
Hormonal regulation of glucose transporters in muscle cells in culture.
Journal of endocrinological investigation 1993;16(2):147-62.
1993: N Bashan; E Burdett; A Gumà; R Sargeant; Laura C Tumiati; Zhi Liu; Amira Klip
Mechanisms of adaptation of glucose transporters to changes in the oxidative chain of muscle and fat cells.
The American journal of physiology 1993;264(2 Pt 1):C430-40.
1993: L Lavoie; D Dimitrakoudis; André Marette; Borhane Annabi; Amira Klip; Mladen Vranic; GERALD VAN DE WERVE
Opposite effects of hyperglycemia and insulin deficiency on liver glycogen synthase phosphatase activity in the diabetic rat.
Diabetes 1993;42(2):363-6.
1993: Harinder S Hundal; Amira Klip
Regulation of glucose transporters and the Na/K-ATPase by insulin in skeletal muscle.
Advances in experimental medicine and biology 1993;334():63-78.
1992: André Marette; E Burdett; A Douen; Mladen Vranic; Amira Klip
Insulin induces the translocation of GLUT4 from a unique intracellular organelle to transverse tubules in rat skeletal muscle.
Diabetes 1992;41(12):1562-9.
1992: D Dimitrakoudis; Mladen Vranic; Amira Klip
Effects of hyperglycemia on glucose transporters of the muscle: use of the renal glucose reabsorption inhibitor phlorizin to control glycemia.
Journal of the American Society of Nephrology : JASN 1992;3(5):1078-91.
1992: Amira Klip; André Marette; D Dimitrakoudis; T Ramlal; Adria Giacca; ZQ Shi; Mladen Vranic
Effect of diabetes on glucoregulation. From glucose transporters to glucose metabolism in vivo.
Diabetes care 1992;15(11):1747-66.
1992: V Sarabia; L Lam; E Burdett; L A Leiter; Amira Klip
Glucose transport in human skeletal muscle cells in culture. Stimulation by insulin and metformin.
The Journal of clinical investigation 1992;90(4):1386-95.
1992: Harinder S Hundal; A Ahmed; A Gumà; Y Mitsumoto; André Marette; M J Rennie; Amira Klip
Biochemical and immunocytochemical localization of the 'GLUT5 glucose transporter' in human skeletal muscle.
The Biochemical journal 1992;286 ( Pt 2)():339-43.
1992: Harinder S Hundal; T Ramlal; R Reyes; L A Leiter; Amira Klip
Cellular mechanism of metformin action involves glucose transporter translocation from an intracellular pool to the plasma membrane in L6 muscle cells.
Endocrinology 1992;131(3):1165-73.
1992: André Marette; J M Richardson; T Ramlal; T W Balon; Mladen Vranic; Jeffrey Pessin; Amira Klip
Abundance, localization, and insulin-induced translocation of glucose transporters in red and white muscle.
The American journal of physiology 1992;263(2 Pt 1):C443-52.
1992: Philip J Bilan; Y Mitsumoto; F Maher; Ian A Simpson; Amira Klip
Detection of the GLUT3 facilitative glucose transporter in rat L6 muscle cells: regulation by cellular differentiation, insulin and insulin-like growth factor-I.
Biochemical and biophysical research communications 1992;186(2):1129-37.
1992: D Dimitrakoudis; T Ramlal; S Rastogi; Mladen Vranic; Amira Klip
Glycaemia regulates the glucose transporter number in the plasma membrane of rat skeletal muscle.
The Biochemical journal 1992;284 ( Pt 2)():341-8.
1992: Amira Klip; A Gumà; T Ramlal; Philip J Bilan; L Lam; L A Leiter
Stimulation of hexose transport by metformin in L6 muscle cells in culture.
Endocrinology 1992;130(5):2535-44.
1992: Y Mitsumoto; Gregory P Downey; Amira Klip
Stimulation of glucose transport in L6 muscle cells by long-term intermittent stretch-relaxation.
FEBS letters 1992;301(1):94-8.
1992: Harinder S Hundal; André Marette; Y Mitsumoto; T Ramlal; R Blostein; Amira Klip
Insulin induces translocation of the alpha 2 and beta 1 subunits of the Na+/K(+)-ATPase from intracellular compartments to the plasma membrane in mammalian skeletal muscle.
The Journal of biological chemistry 1992;267(8):5040-3.
1992: Y Mitsumoto; Amira Klip
Development regulation of the subcellular distribution and glycosylation of GLUT1 and GLUT4 glucose transporters during myogenesis of L6 muscle cells.
The Journal of biological chemistry 1992;267(7):4957-62.
1992: N Bashan; E Burdett; Harinder S Hundal; Amira Klip
Regulation of glucose transport and GLUT1 glucose transporter expression by O2 in muscle cells in culture.
The American journal of physiology 1992;262(3 Pt 1):C682-90.
1992: Philip J Bilan; Y Mitsumoto; T Ramlal; Amira Klip
Acute and long-term effects of insulin-like growth factor I on glucose transporters in muscle cells. Translocation and biosynthesis.
FEBS letters 1992;298(2-3):285-90.
1992: Denis Daneman; Bernard Zinman; M E Elliott; Philip J Bilan; Amira Klip
Insulin-stimulated glucose transport in circulating mononuclear cells from nondiabetic and IDDM subjects.
Diabetes 1992;41(2):227-34.
1991: Gregory D Cartee; A G Douen; T Ramlal; Amira Klip; John O Holloszy
Stimulation of glucose transport in skeletal muscle by hypoxia.
Journal of applied physiology (Bethesda, Md. : 1985) 1991;70(4):1593-600.
1991: Y Mitsumoto; E Burdett; A Grant; Amira Klip
Differential expression of the GLUT1 and GLUT4 glucose transporters during differentiation of L6 muscle cells.
Biochemical and biophysical research communications 1991;175(2):652-9.
1991: U M Koivisto; H Martinez-Valdez; Philip J Bilan; E Burdett; T Ramlal; Amira Klip
Differential regulation of the GLUT-1 and GLUT-4 glucose transport systems by glucose and insulin in L6 muscle cells in culture.
The Journal of biological chemistry 1991;266(4):2615-21.
1991: A G Douen; E Burdett; T Ramlal; S Rastogi; Mladen Vranic; Amira Klip
Characterization of glucose transporter-enriched membranes from rat skeletal muscle: assessment of endothelial cell contamination and presence of sarcoplasmic reticulum and transverse tubules.
Endocrinology 1991;128(1):611-6.
1991: Philip J Bilan; T Ramlal; Amira Klip
IGF-I mediated recruitment of glucose transporters from intracellular membranes to plasma membranes in L6 muscle cells.
Advances in experimental medicine and biology 1991;293():273-88.
1990: Amira Klip; T Ramlal; Philip J Bilan; Gregory D Cartee; Eric Gulve; John O Holloszy
Recruitment of GLUT-4 glucose transporters by insulin in diabetic rat skeletal muscle.
Biochemical and biophysical research communications 1990;172(2):728-36.
1990: A G Douen; T Ramlal; S Rastogi; Philip J Bilan; Gregory D Cartee; Mladen Vranic; John O Holloszy; Amira Klip
Exercise induces recruitment of the "insulin-responsive glucose transporter". Evidence for distinct intracellular insulin- and exercise-recruitable transporter pools in skeletal muscle.
The Journal of biological chemistry 1990;265(23):13427-30.
1990: Amira Klip; M Hill; T Ramlal
Halothane increases cytosolic Ca2+ and inhibits Na+/H+ exchange in L6 muscle cells.
The Journal of pharmacology and experimental therapeutics 1990;254(2):552-9.
1990: Philip J Bilan; Amira Klip
Glycation of the human erythrocyte glucose transporter in vitro and its functional consequences.
The Biochemical journal 1990;268(3):661-7.
1990: Amira Klip; L A Leiter
Cellular mechanism of action of metformin.
Diabetes care 1990;13(6):696-704.
1990: Amira Klip; M R Pâquet
Glucose transport and glucose transporters in muscle and their metabolic regulation.
Diabetes care 1990;13(3):228-43.
1990: Amira Klip; Gordon B Mills; B A Britt; M E Elliott
Halothane-dependent release of intracellular Ca2+ in blood cells in malignant hyperthermia.
The American journal of physiology 1990;258(3 Pt 1):C495-503.
1990: A G Douen; T Ramlal; Gregory D Cartee; Amira Klip
Exercise modulates the insulin-induced translocation of glucose transporters in rat skeletal muscle.
FEBS letters 1990;261(2):256-60.
1990: V Sarabia; T Ramlal; Amira Klip
Glucose uptake in human and animal muscle cells in culture.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1990;68(2):536-42.
1990: P S Walker; T Ramlal; V Sarabia; U M Koivisto; Philip J Bilan; Jeffrey Pessin; Amira Klip
Glucose transport activity in L6 muscle cells is regulated by the coordinate control of subcellular glucose transporter distribution, biosynthesis, and mRNA transcription.
The Journal of biological chemistry 1990;265(3):1516-23.
1990: P J O'Brien; H A Pook; Amira Klip; B A Britt; B I Kalow; R N McLaughlin; E Scott; M E Elliott
Canine stress syndrome/malignant hyperthermia susceptibility: calcium-homeostasis defect in muscle and lymphocytes.
Research in veterinary science 1990;48(1):124-8.
1990: P J O'Brien; Amira Klip; B A Britt; B I Kalow
Malignant hyperthermia susceptibility: biochemical basis for pathogenesis and diagnosis.
Canadian journal of veterinary research = Revue canadienne de recherche vétérinaire 1990;54(1):83-92.
1990: E Burdett; Gordon B Mills; Amira Klip
Effect of GTP gamma S on insulin binding and tyrosine phosphorylation in liver membranes and L6 muscle cells.
The American journal of physiology 1990;258(1 Pt 1):C99-108.
1989: V Sarabia; Amira Klip
Regulation of cytosolic Ca2+ in clonal human muscle cell cultures.
Biochemical and biophysical research communications 1989;165(3):1130-7.
1989: Amira Klip; A G Douen
Role of kinases in insulin stimulation of glucose transport.
The Journal of membrane biology 1989;111(1):1-23.
1989: T Ramlal; S Rastogi; Mladen Vranic; Amira Klip
Decrease in glucose transporter number in skeletal muscle of mildly diabetic (streptozotocin-treated) rats.
Endocrinology 1989;125(2):890-7.
1989: P S Walker; T Ramlal; J A Donovan; T P Doering; A Sandra; Amira Klip; Jeffrey Pessin
Insulin and glucose-dependent regulation of the glucose transport system in the rat L6 skeletal muscle cell line.
The Journal of biological chemistry 1989;264(11):6587-95.
1989: A G Douen; T Ramlal; Amira Klip; D A Young; Gregory D Cartee; John O Holloszy
Exercise-induced increase in glucose transporters in plasma membranes of rat skeletal muscle.
Endocrinology 1989;124(1):449-54.
1988: T Ramlal; V Sarabia; Philip J Bilan; Amira Klip
Insulin-mediated translocation of glucose transporters from intracellular membranes to plasma membranes: sole mechanism of stimulation of glucose transport in L6 muscle cells.
Biochemical and biophysical research communications 1988;157(3):1329-35.
1988: Amira Klip; T Ramlal; A G Douen; Philip J Bilan; K L Skorecki
Inhibition by forskolin of insulin-stimulated glucose transport in L6 muscle cells.
The Biochemical journal 1988;255(3):1023-9.
1988: Amira Klip; T Ramlal; A G Douen; E Burdett; D Young; Gregory D Cartee; John O Holloszy
Insulin-induced decrease in 5'-nucleotidase activity in skeletal muscle membranes.
FEBS letters 1988;238(2):419-23.
1988: E Burdett; Amira Klip
Exofacial regions of the glucose transporter of human erythrocytes: detection with polyclonal antibodies.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1988;66(10):1126-33.
1988: Amira Klip; T Ramlal; U M Koivisto
Stimulation of Na+/H+ exchange by insulin and phorbol ester during differentiation of 3T3-L1 cells. Relation to hexose uptake.
Endocrinology 1988;123(1):296-304.
1987: Amira Klip; T Ramlal; D A Young; John O Holloszy
Insulin-induced translocation of glucose transporters in rat hindlimb muscles.
FEBS letters 1987;224(1):224-30.
1987: Amira Klip; T Ramlal; D Walker; B A Britt; M E Elliott
Selective increase in cytoplasmic calcium by anesthetic in lymphocytes from malignant hyperthermia-susceptible pigs.
Anesthesia and analgesia 1987;66(5):381-5.
1987: Amira Klip; B A Britt; M E Elliott; W Pegg; W Frodis; E Scott
Anaesthetic-induced increase in ionised calcium in blood mononuclear cells from malignant hyperthermia patients.
Lancet 1987;1(8531):463-6.
1986: Amira Klip; B A Britt; M E Elliott; D Walker; T Ramlal; W Pegg
Changes in cytoplasmic free calcium caused by halothane. Role of the plasma membrane and intracellular Ca2+ stores.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1986;64(11):1181-9.