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Henrik Klitgaard

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Cristina Zona; Massimo Pieri; Irene Carunchio; Livia Curcio; Henrik Klitgaard; Doru Georg Margineanu
Brivaracetam (ucb 34714) inhibits Na(+) current in rat cortical neurons in culture.
Rafal M Kaminski; Michel Gillard; Karine Leclercq; Etienne Hanon; Geneviève Lorent; Donald Dassesse; Alain Matagne; Henrik Klitgaard
Proepileptic phenotype of SV2A-deficient mice is associated with reduced anticonvulsant efficacy of levetiracetam.
Doru Georg Margineanu; Henrik Klitgaard
Brivaracetam inhibits spreading depression in rat neocortical slices in vitro.

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All Publications

2010: Cristina Zona; Massimo Pieri; Irene Carunchio; Livia Curcio; Henrik Klitgaard; Doru Georg Margineanu
Brivaracetam (ucb 34714) inhibits Na(+) current in rat cortical neurons in culture.
Epilepsy research 2010;88(1):46-54.
2009: Rafal M Kaminski; Michel Gillard; Karine Leclercq; Etienne Hanon; Geneviève Lorent; Donald Dassesse; Alain Matagne; Henrik Klitgaard
Proepileptic phenotype of SV2A-deficient mice is associated with reduced anticonvulsant efficacy of levetiracetam.
Epilepsia 2009;50(7):1729-40.
2009: Doru Georg Margineanu; Henrik Klitgaard
Brivaracetam inhibits spreading depression in rat neocortical slices in vitro.
Seizure : the journal of the British Epilepsy Association 2009;18(6):453-6.
2008: Alain Matagne; D-G Margineanu; B Kenda; P Michel; Henrik Klitgaard
Anti-convulsive and anti-epileptic properties of brivaracetam (ucb 34714), a high-affinity ligand for the synaptic vesicle protein, SV2A.
British journal of pharmacology 2008;154(8):1662-71.
2008: Rafal M Kaminski; Alain Matagne; Karine Leclercq; Michel Gillard; Philippe Michel; Benoit Kenda; Patrice Talaga; Henrik Klitgaard
SV2A protein is a broad-spectrum anticonvulsant target: functional correlation between protein binding and seizure protection in models of both partial and generalized epilepsy.
Neuropharmacology 2008;54(4):715-20.
2006: Doru Georg Margineanu; Henrik Klitgaard
The connexin 36 blockers quinine, quinidine and mefloquine inhibit cortical spreading depression in a rat neocortical slice model in vitro.
Brain research bulletin 2006;71(1-3):23-8.
2006: Wassilios Meissner; Paula Ravenscroft; René Reese; Daniel Harnack; Rudolf Morgenstern; Andreas Kupsch; Henrik Klitgaard; Bernard Bioulac; Christian E Gross; Erwan Bezard; Thomas Boraud
Increased slow oscillatory activity in substantia nigra pars reticulata triggers abnormal involuntary movements in the 6-OHDA-lesioned rat in the presence of excessive extracellular striatal dopamine.
Neurobiology of disease 2006;22(3):586-98.
2006: Doru Georg Margineanu; Henrik Klitgaard
Differential effects of cation-chloride co-transport-blocking diuretics in a rat hippocampal slice model of epilepsy.
Epilepsy research 2006;69(2):93-9.
2004: Doru Georg Margineanu; Henrik Klitgaard
Caffeine-induced epileptiform field potentials in rat hippocampal slices: a pharmacological characterization.
Neuropharmacology 2004;47(6):926-34.
2004: Michael P Hill; Jonathan M Brotchie; Alan R Crossman; Erwan Bezard; Anne Michel; Renee Grimée; Henrik Klitgaard
Levetiracetam Interferes With the L-dopa priming process in MPTP-lesioned drug-naive marmosets.
Clinical neuropharmacology 2004;27(4):171-7.
2004: Michael P Hill; Paula Ravenscroft; Erwan Bezard; Alan R Crossman; Jonathan M Brotchie; Anne Michel; Renee Grimée; Henrik Klitgaard
Levetiracetam potentiates the antidyskinetic action of amantadine in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned primate model of Parkinson's disease.
The Journal of pharmacology and experimental therapeutics 2004;310(1):386-94.
2004: Isabelle Niespodziany; Henrik Klitgaard; Doru Georg Margineanu
Is the persistent sodium current a specific target of anti-absence drugs?
Neuroreport 2004;15(6):1049-52.
2004: Erwan Bezard; Michael P Hill; Alan R Crossman; Jonathan M Brotchie; Anne Michel; Renee Grimée; Henrik Klitgaard
Levetiracetam improves choreic levodopa-induced dyskinesia in the MPTP-treated macaque.
European journal of pharmacology 2004;485(1-3):159-64.
2004: Andrey Mazarati; Roger Baldwin; Henrik Klitgaard; Alain Matagne; Claude Wasterlain
Anticonvulsant effects of levetiracetam and levetiracetam-diazepam combinations in experimental status epilepticus.
Epilepsy research 2004;58(2-3):167-74.
2004: Benoit M Kenda; Alain Matagne; Patrice Talaga; Patrick M Pasau; Edmond Differding; Bénédicte I Lallemand; Anne M Frycia; Florence G Moureau; Henrik Klitgaard; Michel Gillard; Bruno Fuks; Philippe Michel
Discovery of 4-substituted pyrrolidone butanamides as new agents with significant antiepileptic activity.
Journal of medicinal chemistry 2004;47(3):530-49.
2003: Michael P Hill; Erwan Bezard; Steven G McGuire; Alan R Crossman; Jonathan M Brotchie; Anne Michel; Renee Grimée; Henrik Klitgaard
Novel antiepileptic drug levetiracetam decreases dyskinesia elicited by L-dopa and ropinirole in the MPTP-lesioned marmoset.
Movement disorders : official journal of the Movement Disorder Society 2003;18(11):1301-5.
2003: Michael Madeja; Doru Georg Margineanu; Ali Gorji; Elke Siep; Paul Boerrigter; Henrik Klitgaard; Erwin-Josef Speckmann
Reduction of voltage-operated potassium currents by levetiracetam: a novel antiepileptic mechanism of action?
Neuropharmacology 2003;45(5):661-71.
2003: Bruno Fuks; Michel Gillard; Philippe Michel; Berkley Lynch; Pascale Vertongen; Pierre Leprince; Henrik Klitgaard; Pierre Chatelain
Localization and photoaffinity labelling of the levetiracetam binding site in rat brain and certain cell lines.
European journal of pharmacology 2003;478(1):11-9.
2003: Yves Lamberty; Doru Georg Margineanu; Donald Dassesse; Henrik Klitgaard
H3 agonist immepip markedly reduces cortical histamine release, but only weakly promotes sleep in the rat.
Pharmacological research : the official journal of the Italian Pharmacological Society 2003;48(2):193-8.
2003: Denis Ardid; Yves Lamberty; Abdelkrim Alloui; Marie Ange Coudore-Civiale; Henrik Klitgaard; Alain Eschalier
Antihyperalgesic effect of levetiracetam in neuropathic pain models in rats.
European journal of pharmacology 2003;473(1):27-33.
2003: Isabelle Niespodziany; Henrik Klitgaard; Doru Georg Margineanu
Desynchronizing effect of levetiracetam on epileptiform responses in rat hippocampal slices.
Neuroreport 2003;14(9):1273-6.
2003: Yves Lamberty; Ursula Falter; Alma J Gower; Henrik Klitgaard
Anxiolytic profile of the antiepileptic drug levetiracetam in the Vogel conflict test in the rat.
European journal of pharmacology 2003;469(1-3):97-102.
2003: Henrik Klitgaard; Asla Pitkänen
Antiepileptogenesis, neuroprotection, and disease modification in the treatment of epilepsy: focus on levetiracetam.
Epileptic disorders : international epilepsy journal with videotape 2003;5 Suppl 1():S9-16.
2003: Doru Georg Margineanu; Henrik Klitgaard
Levetiracetam has no significant gamma-aminobutyric acid-related effect on paired-pulse interaction in the dentate gyrus of rats.
European journal of pharmacology 2003;466(3):255-61.
2003: Mikael Angehagen; Doru Georg Margineanu; Elinor Ben-Menachem; Lars Rönnbäck; Elisabeth Hansson; Henrik Klitgaard
Levetiracetam reduces caffeine-induced Ca2+ transients and epileptiform potentials in hippocampal neurons.
Neuroreport 2003;14(3):471-5.
2003: Henrik Klitgaard; Alain Matagne; Renee Grimee; Jocelyne Vanneste-Goemaere; Doru Georg Margineanu
Electrophysiological, neurochemical and regional effects of levetiracetam in the rat pilocarpine model of temporal lobe epilepsy.
Seizure : the journal of the British Epilepsy Association 2003;12(2):92-100.
2002: Henrik Klitgaard; Alain Matagne; Jocelyne Vanneste-Goemaere; Doru Georg Margineanu
Pilocarpine-induced epileptogenesis in the rat: impact of initial duration of status epilepticus on electrophysiological and neuropathological alterations.
Epilepsy research 2002;51(1-2):93-107.
2002: Jean-Michel Rigo; Grégory Hans; Laurent Nguyen; Véronique Rocher; Shibeshih Belachew; Brigitte Malgrange; Pierre Leprince; Gustave Moonen; I Selak; Alain Matagne; Henrik Klitgaard
The anti-epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA- and glycine-gated currents.
British journal of pharmacology 2002;136(5):659-72.
2002: Henrik Klitgaard; Alain Matagne; Yves Lamberty
Use of epileptic animals for adverse effect testing.
Epilepsy research 2002;50(1-2):55-65.
2002: Yves Lamberty; Alma J Gower; Henrik Klitgaard
The new antiepileptic drug levetiracetam normalises chlordiazepoxide withdrawal-induced anxiety in mice.
European journal of pharmacology 2002;439(1-3):101-6.
2001: Doru Georg Margineanu; Henrik Klitgaard
Can gap-junction blockade preferentially inhibit neuronal hypersynchrony vs. excitability?
Neuropharmacology 2001;41(3):377-83.
2001: Isabelle Niespodziany; Henrik Klitgaard; Doru Georg Margineanu
Levetiracetam inhibits the high-voltage-activated Ca(2+) current in pyramidal neurones of rat hippocampal slices.
Neuroscience letters 2001;306(1-2):5-8.
2001: E Hanon; Henrik Klitgaard
Neuroprotective properties of the novel antiepileptic drug levetiracetam in the rat middle cerebral artery occlusion model of focal cerebral ischemia.
Seizure : the journal of the British Epilepsy Association 2001;10(4):287-93.
2001: Cristina Zona; Isabelle Niespodziany; C Marchetti; Henrik Klitgaard; Giorgio Bernardi; Doru Georg Margineanu
Levetiracetam does not modulate neuronal voltage-gated Na+ and T-type Ca2+ currents.
Seizure : the journal of the British Epilepsy Association 2001;10(4):279-86.
2001: Patrice Talaga; Alain Matagne; Henrik Klitgaard
Pharmacological evaluation of a diarylmethylene-piperidine derivative: a new potent atypical antipsychotic?
Bioorganic & medicinal chemistry letters 2001;11(10):1313-6.
2001: A Bocquet; G Lorent; Bruno Fuks; Renee Grimée; Patrice Talaga; J Daliers; Henrik Klitgaard
Failure of GPI compounds to display neurotrophic activity in vitro and in vivo.
European journal of pharmacology 2001;415(2-3):173-80.
2000: Yves Lamberty; Doru Georg Margineanu; Henrik Klitgaard
Absence of negative impact of levetiracetam on cognitive function and memory in normal and amygdala-kindled rats.
Epilepsy & behavior : E&B 2000;1(5):333-42.
2000: Doru Georg Margineanu; Henrik Klitgaard
Inhibition of neuronal hypersynchrony in vitro differentiates levetiracetam from classical antiepileptic drugs.
Pharmacological research : the official journal of the Italian Pharmacological Society 2000;42(4):281-5.
1999: Isabelle Niespodziany; Henrik Klitgaard; Doru Georg Margineanu
Chronic electrode implantation entails epileptiform field potentials in rat hippocampal slices, similarly to amygdala kindling.
Epilepsy research 1999;36(1):69-74.
1998: Henrik Klitgaard; Alain Matagne; J Gobert; E Wülfert
Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy.
European journal of pharmacology 1998;353(2-3):191-206.
1998: Alain Matagne; Henrik Klitgaard
Validation of corneally kindled mice: a sensitive screening model for partial epilepsy in man.
Epilepsy research 1998;31(1):59-71.