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David Adams

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TOP 3
Ryan T Cameron; Ryan G Coleman; Jon P Day; Miles D Houslay; Brian K Shoichet; Krishna C Yalla; David R Adams; George S Baillie
Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4).
Brian D Hudson; Evi Kostenis; David R Adams; Elisabeth Christiansen; Manuel Grundmann; Irina G Tikhonova; Trond Ulven; Graeme Milligan
Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs.
Nicola J Smith; Leigh A Stoddart; Irina G Tikhonova; Christian Tränkle; Trond Ulven; Richard J Ward; David R Adams; Brian D Hudson; Evi Kostenis; Joanne C Morris; Graeme Milligan
Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator.

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All Publications

2013: Ryan T Cameron; Ryan G Coleman; Jon P Day; Miles D Houslay; Brian K Shoichet; Krishna C Yalla; David R Adams; George S Baillie
Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4).
Biochemical pharmacology 2013;85(9):1297-305.
2012: Brian D Hudson; Evi Kostenis; David R Adams; Elisabeth Christiansen; Manuel Grundmann; Irina G Tikhonova; Trond Ulven; Graeme Milligan
Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(12):4951-65.
2011: Nicola J Smith; Leigh A Stoddart; Irina G Tikhonova; Christian Tränkle; Trond Ulven; Richard J Ward; David R Adams; Brian D Hudson; Evi Kostenis; Joanne C Morris; Graeme Milligan
Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator.
Molecular pharmacology 2011;80(1):163-73.
2011: Jonathan P Day; Barbara Lindsay; Tracy Riddell; Zhong Jiang; Robert W Allcock; Achamma Abraham; Sebastian Sookup; Frank Christian; Jana Bogum; Elisabeth K Martin; Robert L Rae; Diana Anthony; Georgina M Rosair; Daniel M Houslay; Elaine Huston; George S Baillie; Enno Klussmann; Miles D Houslay; David R Adams
Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4).
Journal of medicinal chemistry 2011;54(9):3331-47.
2011: Y Y Sin; H V Edwards; Xiang Li; Jonathan P Day; F Christian; Allan J Dunlop; David R Adams; Manuela Zaccolo; Miles D Houslay; George S Baillie
Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes.
Journal of molecular and cellular cardiology 2011;50(5):872-83.
2010: Peter Burton; David R Adams; Achamma Abraham; Robert W Allcock; Zhong Jiang; Angela McCahill; Jane Gilmour; John McAbney; Alexandra Kaupisch; Nicole Kane; George S Baillie; Andrew H Baker; Graeme Milligan; Miles D Houslay; joanne mountford
Erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells.
The Biochemical journal 2010;432(3):575-84.
2010: Frank Christian; Diana F Anthony; Surakiran Vadrevu; Tracy Riddell; Jonathan P Day; Ruth McLeod; David R Adams; George S Baillie; Miles D Houslay
p62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways.
Cellular signalling 2010;22(10):1576-96.
2010: Peter Burton; David R Adams; Achamma Abraham; Robert W Allcock; Zhong Jiang; Angela McCahill; Jane Gilmour; John McAbney; Nicole Kane; George S Baillie; Fergus R McKenzie; Andrew H Baker; Miles D Houslay; joanne mountford; Graeme Milligan
Identification and characterization of small-molecule ligands that maintain pluripotency of human embryonic stem cells.
Biochemical Society transactions 2010;38(4):1058-61.
2010: Xiang Li; Suryakiran Vadrevu; Allan J Dunlop; Jon Day; Noopur Advant; Jessica Troeger; Enno Klussmann; Ellis Jaffrey; Ron Thomas Hay; David R Adams; Miles D Houslay; George S Baillie
Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK.
The Biochemical journal 2010;428(1):55-65.
2009: Xiang Li; Ruth MacLeod; Allan J Dunlop; Helen V Edwards; Noopur Advant; Lucien C D Gibson; Nicola M Devine; Kim M Brown; David R Adams; Miles D Houslay; George S Baillie
A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex.
FEBS letters 2009;583(20):3310-6.
2009: Dong Meng; Martin J Lynch; Elaine Huston; Michael Beyermann; Jenny Eichhorst; David R Adams; Enno Klussmann; Enno Klusmann; Miles D Houslay; George S Baillie
MEK1 binds directly to betaarrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization.
The Journal of biological chemistry 2009;284(17):11425-35.
2008: Tian-Rui Xu; George S Baillie; Narinder Bhari; Thomas M Houslay; Andrew M Pitt; David R Adams; Walter Kolch; Miles D Houslay; Graeme Milligan
Mutations of beta-arrestin 2 that limit self-association also interfere with interactions with the beta2-adrenoceptor and the ERK1/2 MAPKs: implications for beta2-adrenoceptor signalling via the ERK1/2 MAPKs.
The Biochemical journal 2008;413(1):51-60.
2007: K John Smith; George S Baillie; Eva I Hyde; Xiang Li; Thomas M Houslay; Angela McCahill; Allan J Dunlop; Graeme B Bolger; Enno Klussmann; David R Adams; Miles D Houslay
1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, beta-arrestin and RACK1.
Cellular signalling 2007;19(12):2612-24.
2007: George S Baillie; David R Adams; Narinder Bhari; Thomas M Houslay; Suryakiran Vadrevu; Dong Meng; Xiang Li; Allan J Dunlop; Graeme Milligan; Graeme B Bolger; Enno Klussmann; Miles D Houslay
Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of beta-arrestin using spot-immobilized peptide arrays.
The Biochemical journal 2007;404(1):71-80.
2006: Graeme B Bolger; George S Baillie; Xiang Li; Martin J Lynch; Pawel Herzyk; Ahmed Mohamed; Lisa High Mitchell; Angela McCahill; Christian Hundsrucker; Enno Klussmann; David R Adams; Miles D Houslay
Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5.
The Biochemical journal 2006;398(1):23-36.
2004: Lee Ann Johnston; Suat Erdogan; York-Fong Cheung; Michael Sullivan; Rachael Barber; Martin J Lynch; George S Baillie; Gino van Heeke; David R Adams; Elaine Huston; Miles D Houslay
Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene.
The Biochemical journal 2004;380(Pt 2):371-84.
2003: Robert Terry; York-Fong Cheung; Morten Praestegaard; George S Baillie; Elaine Huston; Irene Gall; David R Adams; Miles D Houslay
Occupancy of the catalytic site of the PDE4A4 cyclic AMP phosphodiesterase by rolipram triggers the dynamic redistribution of this specific isoform in living cells through a cyclic AMP independent process.
Cellular signalling 2003;15(10):955-71.
2003: Miles D Houslay; David R Adams
PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization.
The Biochemical journal 2003;370(Pt 1):1-18.