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Peter-M Kloetzel

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Frédéric Ebstein; Peter-M Kloetzel; Orhan Aktas; Ulrike Kuckelkorn; Nicole Lange; Timour Prozorovski; Friederike Schröter; Ulrike Seifert; Antje Voigt; Annika Warnatsch; Elke Krüger
Immunoproteasomes are important for proteostasis in immune responses.
Kathrin Textoris-Taube; Ulrike Kuckelkorn; Christin Keller; Peter-M Kloetzel
Analysis of proteasome generated antigenic peptides by mass spectrometry.
Elke Krüger; Peter-M Kloetzel
Immunoproteasomes at the interface of innate and adaptive immune responses: two faces of one enzyme.

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All Publications

2013: Frédéric Ebstein; Peter-M Kloetzel; Orhan Aktas; Ulrike Kuckelkorn; Nicole Lange; Timour Prozorovski; Friederike Schröter; Ulrike Seifert; Antje Voigt; Annika Warnatsch; Elke Krüger
Immunoproteasomes are important for proteostasis in immune responses.
Cell 2013;152(5):935-7.
2013: Kathrin Textoris-Taube; Ulrike Kuckelkorn; Christin Keller; Peter-M Kloetzel
Analysis of proteasome generated antigenic peptides by mass spectrometry.
Methods in molecular biology (Clifton, N.J.) 2013;960():15-29.
2012: Elke Krüger; Peter-M Kloetzel
Immunoproteasomes at the interface of innate and adaptive immune responses: two faces of one enzyme.
Current opinion in immunology 2012;24(1):77-83.
2011: Melanie Kny; Sybille Standera; Rasmus Hartmann-Petersen; Peter-M Kloetzel; Michael Seeger
Herp regulates Hrd1-mediated ubiquitylation in a ubiquitin-like domain-dependent manner.
The Journal of biological chemistry 2011;286(7):5151-6.
2010: Ulrike Seifert; Lukasz P Bialy; Frédéric Ebstein; Dawadschargal Bech-Otschir; Antje Voigt; Friederike Schröter; Timour Prozorovski; Nicole Lange; Janos Steffen; Melanie Rieger; Ulrike Kuckelkorn; Orhan Aktas; Peter-M Kloetzel; Elke Krüger
Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress.
Cell 2010;142(4):613-24.
2010: Jan Sterz; Christian Jakob; Ulrike Kuckelkorn; Ulrike Heider; Maren Mieth; Lorenz Kleeberg; Martin Kaiser; Peter-M Kloetzel; Orhan Sezer; Ivana von Metzler
BSc2118 is a novel proteasome inhibitor with activity against multiple myeloma.
European journal of haematology 2010;85(2):99-107.
2010: Antje Voigt; Christiane Trimpert; Katrin Bartel; Karl Egerer; Ulrike Kuckelkorn; Eugen Feist; Christine Gericke; Karin Klingel; Reinhard Kandolf; Stephan B Felix; Gert Baumann; Peter-M Kloetzel; Karl Stangl; Alexander Staudt
Lack of evidence for a pathogenic role of proteasome-directed autoimmunity in dilated cardiomyopathy.
Basic research in cardiology 2010;105(4):557-67.
2010: Antje Voigt; Katrin Bartel; Karl Egerer; Christiane Trimpert; Eugen Feist; Christine Gericke; Reinhard Kandolf; Karin Klingel; Ulrike Kuckelkorn; Karl Stangl; Stephan B Felix; Gert Baumann; Peter-M Kloetzel; Alexander Staudt
Humoral anti-proteasomal autoimmunity in dilated cardiomyopathy.
Basic research in cardiology 2010;105(1):9-18.
2009: Frédéric Ebstein; Nicole Lange; Sabrina Urban; Ulrike Seifert; Elke Krüger; Peter-M Kloetzel
Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.
The international journal of biochemistry & cell biology 2009;41(5):1205-15.
2009: Dawadschargal Bech-Otschir; Annett Helfrich; Cordula Enenkel; Gesa Consiglieri; Michael Seeger; Hermann-Georg Holzhütter; Burkhardt Dahlmann; Peter-M Kloetzel
Polyubiquitin substrates allosterically activate their own degradation by the 26S proteasome.
Nature structural & molecular biology 2009;16(2):219-25.
2008: Michele Mishto; Fabio Luciani; Hermann-Georg Holzhütter; Elena Bellavista; Aurelia Santoro; Kathrin Textoris-Taube; Claudio Franceschi; Peter-M Kloetzel; Alexey Zaikin
Modeling the in vitro 20S proteasome activity: the effect of PA28-alphabeta and of the sequence and length of polypeptides on the degradation kinetics.
Journal of molecular biology 2008;377(5):1607-17.
2008: Ulrike Heider; Ivana von Metzler; Martin Kaiser; Marleen Rosche; Jan Sterz; Susanne Rötzer; Jessica Rademacher; Christian Jakob; Claudia Fleissner; Ulrike Kuckelkorn; Peter-M Kloetzel; Orhan Sezer
Synergistic interaction of the histone deacetylase inhibitor SAHA with the proteasome inhibitor bortezomib in mantle cell lymphoma.
European journal of haematology 2008;80(2):133-42.
2007: Eui-Cheol Shin; Ulrike Seifert; Sabrina Urban; Kim-Thuy Truong; Stephen M Feinstone; Charles M Rice; Peter-M Kloetzel; Barbara Rehermann
Proteasome activator and antigen-processing aminopeptidases are regulated by virus-induced type I interferon in the hepatitis C virus-infected liver.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2007;27(12):985-90.
2007: Benjamin Fricke; Sylvia Heink; Janos Steffen; Peter-M Kloetzel; Elke Krüger
The proteasome maturation protein POMP facilitates major steps of 20S proteasome formation at the endoplasmic reticulum.
EMBO reports 2007;8(12):1170-5.
2007: Kathrin Textoris-Taube; Peter Henklein; Sylvie Pollmann; Theresa Bergann; Hardy Weisshoff; Ulrike Seifert; Ilse Drung; Clemens Mügge; Alice J A M Sijts; Peter-M Kloetzel; Ulrike Kuckelkorn
The N-terminal flanking region of the TRP2360-368 melanoma antigen determines proteasome activator PA28 requirement for epitope liberation.
The Journal of biological chemistry 2007;282(17):12749-54.
2007: Antje Voigt; Ulrike Salzmann; Ulrike Seifert; Margitta Dathe; Alejandro Soza; Peter-M Kloetzel; Ulrike Kuckelkorn
20S proteasome-dependent generation of an IEpp89 murine cytomegalovirus-derived H-2L(d) epitope from a recombinant protein.
Biochemical and biophysical research communications 2007;355(2):549-54.
2007: Christian Jakob; Karl Egerer; Peter Liebisch; Seval Türkmen; Ivana Zavrski; Ulrike Kuckelkorn; Ulrike Heider; Martin Kaiser; Claudia Fleissner; Jan Sterz; Lorenz Kleeberg; Eugen Feist; Gerd R Burmester; Peter-M Kloetzel; Orhan Sezer
Circulating proteasome levels are an independent prognostic factor for survival in multiple myeloma.
Blood 2007;109(5):2100-5.
2006: Britta Strehl; Thorsten Joeris; Melanie Rieger; Alexander Visekruna; Kathrin Textoris-Taube; Stefan H E Kaufmann; Peter-M Kloetzel; Ulrike Kuckelkorn; Ulrich Steinhoff
Immunoproteasomes are essential for clearance of Listeria monocytogenes in nonlymphoid tissues but not for induction of bacteria-specific CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):6238-44.
2006: Eui-Cheol Shin; Ulrike Seifert; Takanobu Kato; Charles M Rice; Stephen M Feinstone; Peter-M Kloetzel; Barbara Rehermann
Virus-induced type I IFN stimulates generation of immunoproteasomes at the site of infection.
The Journal of clinical investigation 2006;116(11):3006-14.
2006: Kathrin Sebelin; Antje Schulzki; Peter-M Kloetzel; Bernd Dörken; Antonio Pezzutto; Marion Subklewe
Impairment of circulating myeloid dendritic cells in immunosuppressed renal/pancreas transplant recipients.
Transplantation 2006;82(6):779-87.
2006: Izabela Młynarczuk-Biały; Heike Roeckmann; Ulrike Kuckelkorn; Boris Schmidt; Sumaira Umbreen; Jakub Gołab; Antje Ludwig; Christina Montag; Lüder Wiebusch; Christian Hagemeier; Dirk Schadendorf; Peter-M Kloetzel; Ulrike Seifert
Combined effect of proteasome and calpain inhibition on cisplatin-resistant human melanoma cells.
Cancer research 2006;66(15):7598-605.
2006: S Krause; Ulrike Kuckelkorn; Thomas Dörner; G-R Burmester; Eugen Feist; Peter-M Kloetzel
Immunoproteasome subunit LMP2 expression is deregulated in Sjogren's syndrome but not in other autoimmune disorders.
Annals of the rheumatic diseases 2006;65(8):1021-7.
2006: Michael Brychcy; Ulrike Kuckelkorn; Gert Hausdorf; Karl Egerer; Peter-M Kloetzel; Gerd R Burmester; Eugen Feist
Anti-20S proteasome autoantibodies inhibit proteasome stimulation by proteasome activator PA28.
Arthritis and rheumatism 2006;54(7):2175-83.
2006: Michele Mishto; Aurelia Santoro; Elena Bellavista; Richard Sessions; Kathrin Textoris-Taube; Fabrizio Dal Piaz; Geraldine Carrard; Katia Forti; Stefano Salvioli; Bertrand Friguet; Peter-M Kloetzel; A Jennifer Rivett; Claudio Franceschi
A structural model of 20S immunoproteasomes: effect of LMP2 codon 60 polymorphism on expression, activity, intracellular localisation and insight into the regulatory mechanisms.
Biological chemistry 2006;387(4):417-29.
2006: Martin Kaiser; Ivana Zavrski; Jan Sterz; Christian Jakob; Claudia Fleissner; Peter-M Kloetzel; Orhan Sezer; Ulrike Heider
The effects of the histone deacetylase inhibitor valproic acid on cell cycle, growth suppression and apoptosis in multiple myeloma.
Haematologica 2006;91(2):248-51.
2006: Sylvia Heink; Benjamin Fricke; Daniela Ludwig; Peter-M Kloetzel; Elke Krüger
Tumor cell lines expressing the proteasome subunit isoform LMP7E1 exhibit immunoproteasome deficiency.
Cancer research 2006;66(2):649-52.
2005: Andrea Schulze; Sybille Standera; Elke Buerger; Marjolein Kikkert; Sjaak van Voorden; Emmanuel J H J Wiertz; Frits Koning; Peter-M Kloetzel; Michael Seeger
The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway.
Journal of molecular biology 2005;354(5):1021-7.
2005: Britta Strehl; Ulrike Seifert; Elke Krüger; Sylvia Heink; Ulrike Kuckelkorn; Peter-M Kloetzel
Interferon-gamma, the functional plasticity of the ubiquitin-proteasome system, and MHC class I antigen processing.
Immunological reviews 2005;207():19-30.
2005: Hannes A Braun; Sumaira Umbreen; Michael Groll; Ulrike Kuckelkorn; Izabela Mlynarczuk-Bialy; Moritz E Wigand; Ilse Drung; Peter-M Kloetzel; Boris Schmidt
Tripeptide mimetics inhibit the 20 S proteasome by covalent bonding to the active threonines.
The Journal of biological chemistry 2005;280(31):28394-401.
2005: Xiaohua Huang; Bettina K J Hetfeld; Ulrike Seifert; Thilo Kähne; Peter-M Kloetzel; Michael Naumann; Dawadschargal Bech-Otschir; Wolfgang Dubiel
Consequences of COP9 signalosome and 26S proteasome interaction.
The FEBS journal 2005;272(15):3909-17.
2005: Bettina K J Hetfeld; Annett Helfrich; Barbara Kapelari; Hartmut Scheel; Kay Hofmann; Adi Guterman; Michael Glickman; Rüdiger Schade; Peter-M Kloetzel; Wolfgang Dubiel
The zinc finger of the CSN-associated deubiquitinating enzyme USP15 is essential to rescue the E3 ligase Rbx1.
Current biology : CB 2005;15(13):1217-21.
2005: Sylvia Heink; Daniela Ludwig; Peter-M Kloetzel; Elke Krüger
IFN-gamma-induced immune adaptation of the proteasome system is an accelerated and transient response.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(26):9241-6.
2005: Ferry Ossendorp; Nathalie Fu; Marcel Camps; Francesca Granucci; Sam J P Gobin; Peter J van den Elsen; Danita Schuurhuis; Gosse J Adema; Grayson Lipford; Tomoki Chiba; Alice J A M Sijts; Peter-M Kloetzel; Paola Ricciardi-Castagnoli; Cornelis J M Melief
Differential expression regulation of the alpha and beta subunits of the PA28 proteasome activator in mature dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(12):7815-22.
2005: Stefan Tenzer; Björn Peters; Sascha Bulik; Oliver Schoor; Claudia Lemmel; M M Schatz; Peter-M Kloetzel; Hans-Georg Rammensee; Hansjörg Schild; Hermann-Georg Holzhütter
Modeling the MHC class I pathway by combining predictions of proteasomal cleavage, TAP transport and MHC class I binding.
Cellular and molecular life sciences : CMLS 2005;62(9):1025-37.
2005: Pamir Atagunduz; Heiner Appel; Wolfgang Kuon; Peihua Wu; Andreas Thiel; Peter-M Kloetzel; Joachim Sieper
HLA-B27-restricted CD8+ T cell response to cartilage-derived self peptides in ankylosing spondylitis.
Arthritis and rheumatism 2005;52(3):892-901.
2004: Srinivas Mullapudi; Lee Pullan; Ozlem T Bishop; Hassan Khalil; James K Stoops; Roland Beckmann; Peter-M Kloetzel; Elke Krüger; Pawel A Penczek
Rearrangement of the 16S precursor subunits is essential for the formation of the active 20S proteasome.
Biophysical journal 2004;87(6):4098-105.
2004: Peter-M Kloetzel
The proteasome and MHC class I antigen processing.
Biochimica et biophysica acta 2004;1695(1-3):225-33.
2004: Orhan Aktas; Timour Prozorovski; Alina Smorodchenko; Nicolai E Savaskan; Roland Lauster; Peter-M Kloetzel; Carmen Infante-Duarte; Stefan Brocke; Frauke Zipp
Green tea epigallocatechin-3-gallate mediates T cellular NF-kappa B inhibition and exerts neuroprotection in autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(9):5794-800.
2004: Ulrike Seifert; Heike Liermann; Vito Racanelli; Anne Halenius; Manfred Wiese; Heiner Wedemeyer; Thomas Ruppert; Kay Rispeter; Peter Henklein; Alice J A M Sijts; Hartmut Hengel; Peter-M Kloetzel; Barbara Rehermann
Hepatitis C virus mutation affects proteasomal epitope processing.
The Journal of clinical investigation 2004;114(2):250-9.
2004: Peter-M Kloetzel
Generation of major histocompatibility complex class I antigens: functional interplay between proteasomes and TPPII.
Nature immunology 2004;5(7):661-9.
2004: Peter-M Kloetzel; Ferry Ossendorp
Proteasome and peptidase function in MHC-class-I-mediated antigen presentation.
Current opinion in immunology 2004;16(1):76-81.
2003: G Sébastien Apcher; Sylvia Heink; Daniela Zantopf; Peter-M Kloetzel; Hans-P Schmid; R John Mayer; Elke Krüger
Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits.
FEBS letters 2003;553(1-2):200-4.
2003: Silke Meiners; Dirk Heyken; Andrea Weller; Antje Ludwig; Karl Stangl; Peter-M Kloetzel; Elke Krüger
Inhibition of proteasome activity induces concerted expression of proteasome genes and de novo formation of Mammalian proteasomes.
The Journal of biological chemistry 2003;278(24):21517-25.
2003: Ulrike Seifert; Concepción Marañón; Ayelet Shmueli; Jean-François Desoutter; Lisa Wesoloski; Katharina Janek; Peter Henklein; Susanne Diescher; Muriel Andrieu; Henri de la Salle; Toni Weinschenk; Hansjörg Schild; Diego Laderach; Anne Galy; Gaby Haas; Peter-M Kloetzel; Yuval Reiss; Anne Hosmalin
An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope.
Nature immunology 2003;4(4):375-9.
2003: Christoph Gille; Andrean Goede; Cord Schlöetelburg; Robert Preissner; Peter-M Kloetzel; Ulf B Göbel; Cornelius Frömmel
A comprehensive view on proteasomal sequences: implications for the evolution of the proteasome.
Journal of molecular biology 2003;326(5):1437-48.
2003: Joerg Hakenberg; Alexander K Nussbaum; Hansjörg Schild; Hans-Georg Rammensee; Christina Kuttler; Hermann-Georg Holzhütter; Peter-M Kloetzel; Stefan H E Kaufmann; Hans-Joachim Mollenkopf
MAPPP: MHC class I antigenic peptide processing prediction.
Applied bioinformatics 2003;2(3):155-8.
2003: Elke Krüger; Ulrike Kuckelkorn; Alice J A M Sijts; Peter-M Kloetzel
The components of the proteasome system and their role in MHC class I antigen processing.
Reviews of physiology, biochemistry and pharmacology 2003;148():81-104.
2003: Ralf Stohwasser; Hermann-Georg Holzhütter; Undine Lehmann; Peter Henklein; Peter-M Kloetzel
Hepatitis B virus HBx peptide 116-138 and proteasome activator PA28 compete for binding to the proteasome alpha4/MC6 subunit.
Biological chemistry 2003;384(1):39-49.
2002: Xiaohua Huang; Ulrike Seifert; Ulrike Salzmann; Peter Henklein; Robert Preissner; Wolfgang Henke; Alice J Sijts; Peter-M Kloetzel; Wolfgang Dubiel
The RTP site shared by the HIV-1 Tat protein and the 11S regulator subunit alpha is crucial for their effects on proteasome function including antigen processing.
Journal of molecular biology 2002;323(4):771-82.
2002: Dietmar M W Zaiss; Sybille Standera; Peter-M Kloetzel; Alice J A M Sijts
PI31 is a modulator of proteasome formation and antigen processing.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14344-9.
2002: Karl Egerer; Ulrike Kuckelkorn; Paul E Rudolph; Jens C Rückert; Thomas Dörner; Gerd R Burmester; Peter-M Kloetzel; Eugen Feist
Circulating proteasomes are markers of cell damage and immunologic activity in autoimmune diseases.
The Journal of rheumatology 2002;29(10):2045-52.
2002: Alice J A M Sijts; Yuancheng Sun; Katarina Janek; Sylvie Kral; Annettte Paschen; Dirk Schadendorf; Peter-M Kloetzel
The role of the proteasome activator PA28 in MHC class I antigen processing.
Molecular immunology 2002;39(3-4):165-9.
2002: Yuansheng Sun; Alice J A M Sijts; Mingxia Song; Katharina Janek; Alexander K Nussbaum; Sylvie Kral; Markus Schirle; Stefan Stevanovic; Annette Paschen; Hansjörg Schild; Peter-M Kloetzel; Dirk Schadendorf
Expression of the proteasome activator PA28 rescues the presentation of a cytotoxic T lymphocyte epitope on melanoma cells.
Cancer research 2002;62(10):2875-82.
2002: Ulrike Kuckelkorn; Edite Antunes Ferreira; Ilse Drung; Ulrike Liewer; Peter-M Kloetzel; Matthias Theobald
The effect of the interferon-gamma-inducible processing machinery on the generation of a naturally tumor-associated human cytotoxic T lymphocyte epitope within a wild-type and mutant p53 sequence context.
European journal of immunology 2002;32(5):1368-75.
2002: Ulrike Kuckelkorn; Thomas Ruppert; Britta Strehl; Peter Jungblut; Ursula Zimny-Arndt; Stephanie Lamer; Immo Prinz; Ilse Drung; Peter-M Kloetzel; Stefan H E Kaufmann; Ulrich Steinhoff
Link between organ-specific antigen processing by 20S proteasomes and CD8(+) T cell-mediated autoimmunity.
The Journal of experimental medicine 2002;195(8):983-90.
2002: Andrea Lehmann; Katharina Janek; Beate Braun; Peter-M Kloetzel; Cordula Enenkel
20 S proteasomes are imported as precursor complexes into the nucleus of yeast.
Journal of molecular biology 2002;317(3):401-13.
2002: Karl Stangl; Christoph Günther; Thomas Frank; Mario Lorenz; Silke Meiners; Thorsten Röpke; Lars Stelter; Minoo Moobed; Gert Baumann; Peter-M Kloetzel; Verena Stangl
Inhibition of the ubiquitin-proteasome pathway induces differential heat-shock protein response in cardiomyocytes and renders early cardiac protection.
Biochemical and biophysical research communications 2002;291(3):542-9.
2002: Silke Meiners; Michael Laule; Wim Rother; Christoph Guenther; Ines Prauka; Peter Muschick; Gert Baumann; Peter-M Kloetzel; Karl Stangl
Ubiquitin-proteasome pathway as a new target for the prevention of restenosis.
Circulation 2002;105(4):483-9.
2002: Anja Bubeck; Uwe Reusch; Markus Wagner; Thomas Ruppert; Walter Muranyi; Peter-M Kloetzel; Ulrich H Koszinowski
The glycoprotein gp48 of murine cytomegalovirusL proteasome-dependent cytosolic dislocation and degradation.
The Journal of biological chemistry 2002;277(3):2216-24.
2001: Wolfgang Kuon; Hermann-Georg Holzhütter; Heiner Appel; M Grolms; Simon Kollnberger; A Traeder; Peter Henklein; E Weiss; Andreas Thiel; Roland Lauster; Paul Bowness; Andreas Radbruch; Peter-M Kloetzel; Joachim Sieper
Identification of HLA-B27-restricted peptides from the Chlamydia trachomatis proteome with possible relevance to HLA-B27-associated diseases.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(8):4738-46.
2001: C Knuehl; Pieter Spee; Thomas Ruppert; Ulrike Kuckelkorn; Peter Henklein; Jacques Neefjes; Peter-M Kloetzel
The murine cytomegalovirus pp89 immunodominant H-2Ld epitope is generated and translocated into the endoplasmic reticulum as an 11-mer precursor peptide.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(3):1515-21.
2001: Burkhardt Dahlmann; T Ruppert; Peter-M Kloetzel; Lothar Kuehn
Subtypes of 20S proteasomes from skeletal muscle.
Biochimie 2001;83(3-4):295-9.
2001: Elke Krüger; Peter-M Kloetzel; Cordula Enenkel
20S proteasome biogenesis.
Biochimie 2001;83(3-4):289-93.
2000: K Schwarz; M Eggers; Alejandro Soza; Ulrich H Koszinowski; Peter-M Kloetzel; Marcus Groettrup
The proteasome regulator PA28alpha/beta can enhance antigen presentation without affecting 20S proteasome subunit composition.
European journal of immunology 2000;30(12):3672-9.
2000: Burkhardt Dahlmann; T Ruppert; Lothar Kuehn; Simone Merforth; Peter-M Kloetzel
Different proteasome subtypes in a single tissue exhibit different enzymatic properties.
Journal of molecular biology 2000;303(5):643-53.
2000: Ulrike Kuckelkorn; C Knuehl; B Boes-Fabian; Ilse Drung; Peter-M Kloetzel
The effect of heat shock on 20S/26S proteasomes.
Biological chemistry 2000;381(9-10):1017-23.
2000: Eugen Feist; Thomas Dörner; Ulrike Kuckelkorn; Sonja Scheffler; Gerd R Burmester; Peter-M Kloetzel
Diagnostic importance of anti-proteasome antibodies.
International archives of allergy and immunology 2000;123(1):92-7.
2000: Alice J A M Sijts; Marcel Camps; Rienk Offringa; Cornelis J M Melief; Peter-M Kloetzel; Ferry Ossendorp
Differential influence on cytotoxic T lymphocyte epitope presentation by controlled expression of either proteasome immunosubunits or PA28.
The Journal of experimental medicine 2000;192(4):483-94.
2000: E Witt; Daniela Zantopf; Marion Schmidt; R Kraft; Peter-M Kloetzel; Elke Krüger
Characterisation of the newly identified human Ump1 homologue POMP and analysis of LMP7(beta 5i) incorporation into 20 S proteasomes.
Journal of molecular biology 2000;301(1):1-9.
2000: K Schwarz; Maries van den Broek; Susanne Kostka; R Kraft; Alejandro Soza; Gunter Schmidtke; Peter-M Kloetzel; Marcus Groettrup
Overexpression of the proteasome subunits LMP2, LMP7, and MECL-1, but not PA28 alpha/beta, enhances the presentation of an immunodominant lymphocytic choriomeningitis virus T cell epitope.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(2):768-78.
2000: Alice J A M Sijts; Sybille Standera; R E Toes; Thomas Ruppert; Nico J Beekman; Peter van Veelen; Ferry Ossendorp; Cornelis J M Melief; Peter-M Kloetzel
MHC class I antigen processing of an adenovirus CTL epitope is linked to the levels of immunoproteasomes in infected cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(9):4500-6.
2000: Nico J Beekman; Peter van Veelen; Thorbald van Hall; A Neisig; Alice J A M Sijts; Marcel Camps; Peter-M Kloetzel; Jacques Neefjes; Cornelis J M Melief; Ferry Ossendorp
Abrogation of CTL epitope processing by single amino acid substitution flanking the C-terminal proteasome cleavage site.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(4):1898-905.
2000: Ralf Stohwasser; J Giesebrecht; R Kraft; EC Müller; Karl Georg Häusler; Helmut Kettenmann; Uwe-Karsten Hanisch; Peter-M Kloetzel
Biochemical analysis of proteasomes from mouse microglia: induction of immunoproteasomes by interferon-gamma and lipopolysaccharide.
Glia 2000;29(4):355-65.
2000: Alice J A M Sijts; Thomas Ruppert; Barbara Rehermann; Marion Schmidt; Ulrich H Koszinowski; Peter-M Kloetzel
Efficient generation of a hepatitis B virus cytotoxic T lymphocyte epitope requires the structural features of immunoproteasomes.
The Journal of experimental medicine 2000;191(3):503-14.
2000: Ralf Stohwasser; Alejandro Soza; M Eggers; Ulrich H Koszinowski; Peter-M Kloetzel
PA28alphabeta double and PA28beta single transfectant mouse B8 cell lines reveal enhanced presentation of a mouse cytomegalovirus (MCMV) pp89 MHC class I epitope.
Molecular immunology 2000;37(1-2):13-9.
1999: Dietmar M W Zaiss; Sybille Standera; Hermann-Georg Holzhütter; Peter-M Kloetzel; Alice J A M Sijts
The proteasome inhibitor PI31 competes with PA28 for binding to 20S proteasomes.
FEBS letters 1999;457(3):333-8.
1999: B C Braun; M Glickman; R Kraft; Burkhardt Dahlmann; Peter-M Kloetzel; D Finley; Marion Schmidt
The base of the proteasome regulatory particle exhibits chaperone-like activity.
Nature cell biology 1999;1(4):221-6.
1999: Ulrike Salzmann; Sylvie Kral; B Braun; Sybille Standera; Marion Schmidt; Peter-M Kloetzel; Alice J A M Sijts
Mutational analysis of subunit i beta2 (MECL-1) demonstrates conservation of cleavage specificity between yeast and mammalian proteasomes.
FEBS letters 1999;454(1-2):11-5.
1999: Marion Schmidt; Daniela Zantopf; R Kraft; Susanne Kostka; R Preissner; Peter-M Kloetzel
Sequence information within proteasomal prosequences mediates efficient integration of beta-subunits into the 20 S proteasome complex.
Journal of molecular biology 1999;288(1):117-28.
1999: Dietmar M W Zaiss; Peter-M Kloetzel
A second gene encoding the mouse proteasome activator PA28beta subunit is part of a LINE1 element and is driven by a LINE1 promoter.
Journal of molecular biology 1999;287(5):829-35.
1999: Cordula Enenkel; Andrea Lehmann; Peter-M Kloetzel
GFP-labelling of 26S proteasomes in living yeast: insight into proteasomal functions at the nuclear envelope/rough ER.
Molecular biology reports 1999;26(1-2):131-5.
1999: Eugen Feist; Ulrike Kuckelkorn; Thomas Dörner; H Dönitz; Sonja Scheffler; Falk Hiepe; Peter-M Kloetzel; Gerd R Burmester
Autoantibodies in primary Sjögren's syndrome are directed against proteasomal subunits of the alpha and beta type.
Arthritis and rheumatism 1999;42(4):697-702.
1999: Peter-M Kloetzel; Alejandro Soza; Ralf Stohwasser
The role of the proteasome system and the proteasome activator PA28 complex in the cellular immune response.
Biological chemistry 1999;380(3):293-7.
1998: Cordula Enenkel; Andrea Lehmann; Peter-M Kloetzel
Subcellular distribution of proteasomes implicates a major location of protein degradation in the nuclear envelope-ER network in yeast.
The EMBO journal 1998;17(21):6144-54.
1998: Matthias Theobald; Thomas Ruppert; Ulrike Kuckelkorn; J Hernandez; A Häussler; Edite Antunes Ferreira; Ulrike Liewer; Judith A Biggs; Arnold J Levine; Christoph Huber; Ulrich H Koszinowski; Peter-M Kloetzel; Linda A Sherman
The sequence alteration associated with a mutational hotspot in p53 protects cells from lysis by cytotoxic T lymphocytes specific for a flanking peptide epitope.
The Journal of experimental medicine 1998;188(6):1017-28.
1998: Robert Kraft; Susanne Kostka; Gerlinde Grelle; P Henklein; Peter-M Kloetzel; U Kuckelhorn
Influence of single amino acid exchanges in epitope generation by 20S proteasome.
Journal of protein chemistry 1998;17(6):547-8.
1998: Gunter Schmidtke; M Eggers; Thomas Ruppert; Marcus Groettrup; Ulrich H Koszinowski; Peter-M Kloetzel
Inactivation of a defined active site in the mouse 20S proteasome complex enhances major histocompatibility complex class I antigen presentation of a murine cytomegalovirus protein.
The Journal of experimental medicine 1998;187(10):1641-6.
1997: M Groettrup; Sybille Standera; Ralf Stohwasser; Peter-M Kloetzel
The subunits MECL-1 and LMP2 are mutually required for incorporation into the 20S proteasome.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(17):8970-5.
1997: Alejandro Soza; C Knuehl; M Groettrup; P Henklein; K Tanaka; Peter-M Kloetzel
Expression and subcellular localization of mouse 20S proteasome activator complex PA28.
FEBS letters 1997;413(1):27-34.
1997: Ralf Stohwasser; Sybille Standera; I Peters; Peter-M Kloetzel; M Groettrup
Molecular cloning of the mouse proteasome subunits MC14 and MECL-1: reciprocally regulated tissue expression of interferon-gamma-modulated proteasome subunits.
European journal of immunology 1997;27(5):1182-7.
1997: Gunter Schmidtke; Marion Schmidt; Peter-M Kloetzel
Maturation of mammalian 20 S proteasome: purification and characterization of 13 S and 16 S proteasome precursor complexes.
Journal of molecular biology 1997;268(1):95-106.
1997: Marion Schmidt; Gunter Schmidtke; Peter-M Kloetzel
Structure and structure formation of the 20S proteasome.
Molecular biology reports 1997;24(1-2):103-12.
1996: Gunter Schmidtke; R Kraft; Susanne Kostka; P Henklein; Cornelius Frömmel; J Löwe; Robert Huber; Peter-M Kloetzel; Marion Schmidt
Analysis of mammalian 20S proteasome biogenesis: the maturation of beta-subunits is an ordered two-step mechanism involving autocatalysis.
The EMBO journal 1996;15(24):6887-98.
1996: Eugen Feist; T Dörner; Ulrike Kuckelkorn; Gunter Schmidtke; B Micheel; Falk Hiepe; Gerd R Burmester; Peter-M Kloetzel
Proteasome alpha-type subunit C9 is a primary target of autoantibodies in sera of patients with myositis and systemic lupus erythematosus.
The Journal of experimental medicine 1996;184(4):1313-8.
1996: Ralf Stohwasser; Peter-M Kloetzel
Cytokine induced changes in proteasome subunit composition are concentration dependent.
Biological chemistry 1996;377(9):571-7.
1996: Marcus Groettrup; Alejandro Soza; Ulrike Kuckelkorn; Peter-M Kloetzel
Peptide antigen production by the proteasome: complexity provides efficiency.
Immunology today 1996;17(9):429-35.
1996: TP Dick; T Ruppert; Marcus Groettrup; Peter-M Kloetzel; L Kuehn; Ulrich H Koszinowski; S Stevanović; Hansjörg Schild; Hans-Georg Rammensee
Coordinated dual cleavages induced by the proteasome regulator PA28 lead to dominant MHC ligands.
Cell 1996;86(2):253-62.
1996: C Knuehl; Anna Seelig; B Brecht; P Henklein; Peter-M Kloetzel
Functional analysis of eukaryotic 20S proteasome nuclear localization signal.
Experimental cell research 1996;225(1):67-74.
1996: Marcus Groettrup; Alejandro Soza; M Eggers; L Kuehn; TP Dick; Hansjörg Schild; Hans-Georg Rammensee; Ulrich H Koszinowski; Peter-M Kloetzel
A role for the proteasome regulator PA28alpha in antigen presentation.
Nature 1996;381(6578):166-8.
1996: Marcus Groettrup; R Kraft; Susanne Kostka; Sybille Standera; Ralf Stohwasser; Peter-M Kloetzel
A third interferon-gamma-induced subunit exchange in the 20S proteasome.
European journal of immunology 1996;26(4):863-9.
1996: Ralf Stohwasser; Ulrike Kuckelkorn; R Kraft; Susanne Kostka; Peter-M Kloetzel
20S proteasome from LMP7 knock out mice reveals altered proteolytic activities and cleavage site preferences.
FEBS letters 1996;383(1-2):109-13.
1996: R Rotem-Yehudar; Marcus Groettrup; Alejandro Soza; Peter-M Kloetzel; Rachel Ehrlich
LMP-associated proteolytic activities and TAP-dependent peptide transport for class 1 MHC molecules are suppressed in cell lines transformed by the highly oncogenic adenovirus 12.
The Journal of experimental medicine 1996;183(2):499-514.
1995: M Eggers; B Boes-Fabian; T Ruppert; Peter-M Kloetzel; Ulrich H Koszinowski
The cleavage preference of the proteasome governs the yield of antigenic peptides.
The Journal of experimental medicine 1995;182(6):1865-70.
1995: Marcus Groettrup; T Ruppert; L Kuehn; M Seeger; Sybille Standera; Ulrich H Koszinowski; Peter-M Kloetzel
The interferon-gamma-inducible 11 S regulator (PA28) and the LMP2/LMP7 subunits govern the peptide production by the 20 S proteasome in vitro.
The Journal of biological chemistry 1995;270(40):23808-15.
1995: Ulrike Kuckelkorn; S Frentzel; R Kraft; Susanne Kostka; Marcus Groettrup; Peter-M Kloetzel
Incorporation of major histocompatibility complex--encoded subunits LMP2 and LMP7 changes the quality of the 20S proteasome polypeptide processing products independent of interferon-gamma.
European journal of immunology 1995;25(9):2605-11.
1994: S Frentzel; B Pesold-Hurt; Anna Seelig; Peter-M Kloetzel
20 S proteasomes are assembled via distinct precursor complexes. Processing of LMP2 and LMP7 proproteins takes place in 13-16 S preproteasome complexes.
Journal of molecular biology 1994;236(4):975-81.
1994: B Boes; Hartmut Hengel; T Ruppert; Gerd Multhaup; Ulrich H Koszinowski; Peter-M Kloetzel
Interferon gamma stimulation modulates the proteolytic activity and cleavage site preference of 20S mouse proteasomes.
The Journal of experimental medicine 1994;179(3):901-9.
1993: Anna Seelig; Gerd Multhaup; B Pesold-Hurt; Konrad Beyreuther; Peter-M Kloetzel
Drosophila proteasome Dm25 subunit substitutes the mouse MC3 subunit in hybrid proteasomes. The N-terminal domain is essential for subunit incorporation.
The Journal of biological chemistry 1993;268(34):25561-7.
1993: Anna Seelig; M Troxell; Peter-M Kloetzel
Sequence and genomic organization of the Drosophila proteasome PROS-Dm25 gene.
Biochimica et biophysica acta 1993;1174(2):215-7.
1993: S Frentzel; I Kuhn-Hartmann; M Gernold; P Gött; Anna Seelig; Peter-M Kloetzel
The major-histocompatibility-complex-encoded beta-type proteasome subunits LMP2 and LMP7. Evidence that LMP2 and LMP7 are synthesized as proproteins and that cellular levels of both mRNA and LMP-containing 20S proteasomes are differentially regulated.
European journal of biochemistry / FEBS 1993;216(1):119-26.
1993: M Gernold; U Knauf; Matthias Gaestel; J Stahl; Peter-M Kloetzel
Development and tissue-specific distribution of mouse small heat shock protein hsp25.
Developmental genetics 1993;14(2):103-11.
1992: S Frentzel; U Gräf; Günter J Hämmerling; Peter-M Kloetzel
Isolation and characterization of the MHC linked beta-type proteasome subunit MC13 cDNA.
FEBS letters 1992;302(2):121-5.
1992: S Frentzel; M Troxell; Christian Haass; B Pesold-Hurt; K H Glätzer; Peter-M Kloetzel
Molecular characterization of the genomic regions of the Drosophila alpha-type subunit proteasome genes PROS-Dm28.1 and PROS-Dm35.
European journal of biochemistry / FEBS 1992;205(3):1043-51.
1991: Anna Seelig; Peter-M Kloetzel; L Kuehn; Burkhardt Dahlmann
Molecular interaction of the proteasome (multicatalytic proteinase). Evidence that the proteasome is not a constituent of the '26 S' multienzyme complex.
The Biochemical journal 1991;280 ( Pt 1)():225-32.
1991: V Ortiz-Navarrete; Anna Seelig; M Gernold; S Frentzel; Peter-M Kloetzel; Günter J Hämmerling
Subunit of the '20S' proteasome (multicatalytic proteinase) encoded by the major histocompatibility complex.
Nature 1991;353(6345):662-4.
1991: Peter-M Kloetzel; S Frentzel; M Gernold; Christian Haass; U Klein; B Pesold-Hurt; Anna Seelig
The proteasome of Drosophila and features of the evolutionarily conserved PROS-gene family.
Biomedica biochimica acta 1991;50(4-6):451-7.
1990: U Klein; M Gernold; Peter-M Kloetzel
Cell-specific accumulation of Drosophila proteasomes (MCP) during early development.
The Journal of cell biology 1990;111(6 Pt 1):2275-82.
1990: Christian Haass; B Pesold-Hurt; Peter-M Kloetzel
The Drosophila PROS-29 gene is a new member of the PROS-gene family.
Nucleic acids research 1990;18(13):4018.
1990: Christian Haass; B Pesold-Hurt; Gerd Multhaup; Konrad Beyreuther; Peter-M Kloetzel
The Drosophila PROS-28.1 gene is a member of the proteasome gene family.
Gene 1990;90(2):235-41.
1989: Christian Haass; B Pesold-Hurt; Gerd Multhaup; Konrad Beyreuther; Peter-M Kloetzel
The PROS-35 gene encodes the 35 kd protein subunit of Drosophila melanogaster proteasome.
The EMBO journal 1989;8(8):2373-9.
1989: P E Falkenburg; Peter-M Kloetzel
Identification and characterization of three different subpopulations of the Drosophila multicatalytic proteinase (proteasome).
The Journal of biological chemistry 1989;264(12):6660-6.
1989: Johannes Schenkel; Peter-M Kloetzel
In vitro reconstitution of hnRNP particles.
FEBS letters 1989;247(1):51-4.
1989: Christian Haass; Peter-M Kloetzel
The Drosophila proteasome undergoes changes in its subunit pattern during development.
Experimental cell research 1989;180(1):243-52.
1988: P E Falkenburg; Christian Haass; Peter-M Kloetzel; B Niedel; Friedrich Kopp; L Kuehn; Burkhardt Dahlmann
Drosophila small cytoplasmic 19S ribonucleoprotein is homologous to the rat multicatalytic proteinase.
Nature 1988;331(6152):190-2.
1987: Peter-M Kloetzel; P E Falkenburg; P Hössl; K H Glätzer
The 19S ring-type particles of Drosophila. Cytological and biochemical analysis of their intracellular association and distribution.
Experimental cell research 1987;170(1):204-13.
1986: K H Glätzer; Peter-M Kloetzel
Differential chromosomal distribution of ribonucleoprotein antigens in nuclei of Drosophila spermatocytes.
The Journal of cell biology 1986;103(6 Pt 1):2113-9.
1983: Peter-M Kloetzel; Ekkehard K F Bautz
Heat-shock proteins are associated with hnRNA in Drosophila melanogaster tissue culture cells.
The EMBO journal 1983;2(5):705-10.