Username

Password

Forgot Password?

Preview

Sign-in free and Explore the Exciting World of BiomedExperts:

Over 1.500.000 Profiles
More than 1.800 Organizations worldwide
State of the Art Network Visualizations

Manage your own Profile
Locate Experts in your Country/Region
Locate Experts in your 1. and 2. Level Network
Connect to Experts Worldwide

NetworkView

Gilles Klopman

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Concepts & Ideas

Chemicals & Drugs

Procedures

Activities & Behaviors

Genes & Molecular Sequences

Molecular Structure

Living Beings

Occupations

Drug Design

Sign-in to see full Profile

Network (preview)

Co-Publications
Name
5
Saiakhov, Roustem
5
Zhu, Hao
4
Sedykh, Aleksandr
4
Chakravarti, Shukti
3
Ivanov, Julian
2
Kruhlak, Naomi
2
Matthews, Edwin
2
Contrera, Joseph
2
Yang, Chihae
1
Zagorski, Michael
1
van de Sandt, Johannes
1
Veith, Gilman
1
Wang, Shaomeng
1
Worth, Andrew
1
Benigni, Romualdo

Sign-in to see all Coauthors

Publications

TOP 3
Matthews Edwin J; Ursem Carling J; Kruhlak Naomi L; Benz R Daniel; Sabaté David Aragonés; Yang Chihae; Klopman Gilles; Contrera Joseph F
Identification of structure-activity relationships for adverse effects of pharmaceuticals in humans: Part B. Use of (Q)SAR systems for early detection of drug-induced hepatobiliary and urinary tract toxicities.
Chakravarti Suman K; Klopman Gilles
A structural analysis of the differential cytotoxicity of chemicals in the NCI-60 cancer cell lines.
Sedykh A; Klopman G
Data analysis and alternative modelling of MITI-I aerobic biodegradation.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of Gilles Klopman (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Matthews Edwin J; Ursem Carling J; Kruhlak Naomi L; Benz R Daniel; Sabaté David Aragonés; Yang Chihae; Klopman Gilles; Contrera Joseph F
Identification of structure-activity relationships for adverse effects of pharmaceuticals in humans: Part B. Use of (Q)SAR systems for early detection of drug-induced hepatobiliary and urinary tract toxicities.
Regulatory toxicology and pharmacology : RTP 2009;54(1):23-42.
2008: Chakravarti Suman K; Klopman Gilles
A structural analysis of the differential cytotoxicity of chemicals in the NCI-60 cancer cell lines.
Bioorganic & medicinal chemistry 2008;16(7):4052-63.
2007: Sedykh A; Klopman G
Data analysis and alternative modelling of MITI-I aerobic biodegradation.
SAR and QSAR in environmental research 2007;18(7-8):693-709.
2007: Matthews Edwin J; Kruhlak Naomi L; Daniel Benz R; Ivanov Julian; Klopman Gilles; Contrera Joseph F
A comprehensive model for reproductive and developmental toxicity hazard identification: II. Construction of QSAR models to predict activities of untested chemicals.
Regulatory toxicology and pharmacology : RTP 2007;47(2):136-55.
2006: Sedykh Aleksandr Y; Klopman Gilles
A structural analogue approach to the prediction of the octanol-water partition coefficient.
Journal of chemical information and modeling 2006;46(4):1598-603.
2005: Netzeva Tatiana I; Worth Andrew; Aldenberg Tom; Benigni Romualdo; Cronin Mark T D; Gramatica Paolo; Jaworska Joanna S; Kahn Scott; Klopman Gilles; Marchant Carol A; Myatt Glenn; Nikolova-Jeliazkova Nina; Patlewicz Grace Y; Perkins Roger; Roberts David; Schultz Terry; Stanton David W; van de Sandt Johannes J M; Tong Weida; Veith Gilman; Yang Chihae
Current status of methods for defining the applicability domain of (quantitative) structure-activity relationships. The report and recommendations of ECVAM Workshop 52.
Alternatives to laboratory animals : ATLA 2005;33(2):155-73.
2005: Klopman Gilles; Zhu Hao
Recent methodologies for the estimation of n-octanol/water partition coefficients and their use in the prediction of membrane transport properties of drugs.
Mini reviews in medicinal chemistry 2005;5(2):127-33.
2004: Klopman G; Zhu H; Fuller M A; Saiakhov R D
Searching for an enhanced predictive tool for mutagenicity.
SAR and QSAR in environmental research 2004;15(4):251-63.
2004: Klopman Gilles; Chakravarti Suman K; Zhu Hao; Ivanov Julian M; Saiakhov Roustem D
ESP: a method to predict toxicity and pharmacological properties of chemicals using multiple MCASE databases.
Journal of chemical information and computer sciences 2004;44(2):704-15.
2003: Klopman Gilles; Zhu Hao; Ecker Gerhard; Chiba Peter
MCASE study of the multidrug resistance reversal activity of propafenone analogs.
Journal of computer-aided molecular design 2003;17(5-6):291-7.
2003: Klopman Gilles; Chakravarti Suman K
Screening of high production volume chemicals for estrogen receptor binding activity (II) by the MultiCASE expert system.
Chemosphere 2003;51(6):461-8.
2003: Klopman Gilles; Chakravarti Suman K
Structure-activity relationship study of a diverse set of estrogen receptor ligands (I) using MultiCASE expert system.
Chemosphere 2003;51(6):445-59.
2003: Klopman G; Chakravarti S K; Harris N; Ivanov J; Saiakhov R D
In-silico screening of high production volume chemicals for mutagenicity using the MCASE QSAR expert system.
SAR and QSAR in environmental research 2003;14(2):165-80.
2003: Klopman Gilles; Stuart Scott E
Multiple computer-automated structure evaluation study of aquatic toxicity. III. Vibrio fischeri.
Environmental toxicology and chemistry / SETAC 2003;22(3):466-72.
2002: Klopman Gilles; Stefan Liliana R; Saiakhov Roustem D
ADME evaluation. 2. A computer model for the prediction of intestinal absorption in humans.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2002;17(4-5):253-63.
2002: Klopman Gilles; Sedykh Aleksandr
An MCASE approach to the search of a cure for Parkinson's Disease.
BMC pharmacology 2002;2():8.
2001: Sedykh A; Saiakhov R; Klopman G
META V. A model of photodegradation for the prediction of photoproducts of chemicals under natural-like conditions.
Chemosphere 2001;45(6-7):971-81.
2001: Klopman G; Zhu H
Estimation of the aqueous solubility of organic molecules by the group contribution approach.
Journal of chemical information and computer sciences 2001;41(2):439-45.
1999: Klopman G; Tu M
Diversity analysis of 14 156 molecules tested by the National Cancer Institute for anti-HIV activity using the quantitative structure-activity relational expert system MCASE.
Journal of medicinal chemistry 1999;42(6):992-8.
1998: Klopman G
The MultiCASE program II. Baseline activity identification algorithm (BAIA).
Journal of chemical information and computer sciences 1998;38(1):78-81.
1997: Venkataprasad N; Jacobs M R; Johnson J L; Klopman G; Ellner J J
Activity of new quinolones against intracellular Mycobacterium avium in human monocytes.
The Journal of antimicrobial chemotherapy 1997;40(6):841-5.
1997: Klopman G; Shi L M; Ramu A
Quantitative structure-activity relationship of multidrug resistance reversal agents.
Molecular pharmacology 1997;52(2):323-34.
1997: Klopman G; Tu M; Talafous J
META. 3. A genetic algorithm for metabolic transform priorities optimization.
Journal of chemical information and computer sciences 1997;37(2):329-34.
1995: Klopman G; Zhang Z; Woodgate S D; Rosenkranz H S
The structure-toxicity relationship challenge at hazardous waste sites.
Chemosphere 1995;31(1):2511-9.
1995: Klopman G; Li J Y
Quantitative structure-agonist activity relationship of capsaicin analogues.
Journal of computer-aided molecular design 1995;9(3):283-94.
1994: Talafous J; Sayre L M; Mieyal J J; Klopman G
META. 2. A dictionary model of mammalian xenobiotic metabolism.
Journal of chemical information and computer sciences 1994;34(6):1326-33.
1994: Klopman G; Dimayuga M; Talafous J
META. 1. A program for the evaluation of metabolic transformation of chemicals.
Journal of chemical information and computer sciences 1994;34(6):1320-5.
1994: Talafous J; Marcinowski K J; Klopman G; Zagorski M G
Solution structure of residues 1-28 of the amyloid beta-peptide.
Biochemistry 1994;33(25):7788-96.
1994: Klopman G; Rosenkranz H S
International Commission for Protection Against Environmental Mutagens and Carcinogens. Approaches to SAR in carcinogenesis and mutagenesis. Prediction of carcinogenicity/mutagenicity using MULTI-CASE.
Mutation research 1994;305(1):33-46.
1993: Klopman G; Ptchelintsev D
Antifungal triazole alcohols: a comparative analysis of structure-activity, structure-teratogenicity and structure-therapeutic index relationships using the Multiple Computer-Automated Structure Evaluation (Multi-CASE) methodology.
Journal of computer-aided molecular design 1993;7(3):349-62.
1992: Klopman G; Wang S; Balthasar D M
Estimation of aqueous solubility of organic molecules by the group contribution approach. Application to the study of biodegradation.
Journal of chemical information and computer sciences 1992;32(5):474-82.
1992: Klopman G; Rosenkranz H S
Testing by artificial intelligence: computational alternatives to the determination of mutagenicity.
Mutation research 1992;272(1):59-71.
1992: Mersch-Sundermann V; Rosenkranz H S; Klopman G
Structural basis of the genotoxicity of polycyclic aromatic hydrocarbons.
Mutagenesis 1992;7(3):211-8.
1992: Mersch-Sundermann V; Klopman G; Rosenkranz H S
Structural requirements for the induction of the SOS repair in bacteria by nitrated polycyclic aromatic hydrocarbons and related chemicals.
Mutation research 1992;265(1):61-73.
1991: Klopman G; Rosenkranz H
Structure-activity relations: maximizing the usefulness of mutagenicity and carcinogenicity databases.
Environmental health perspectives 1991;96():67-75.
1991: Klopman G; Rosenkranz H S
Quantification of the predictivity of some short-term assays for carcinogenicity in rodents.
Mutation research 1991;253(3):237-40.
1991: Rosenkranz H S; Klopman G
A re-examination of the genotoxicity and carcinogenicity of azathioprine.
Mutation research 1991;251(1):157-61; discussion 163-4.
1990: Rosenkranz H S; Klopman G
Methapyrilene: DNA as a possible target.
Mutation research 1990;245(4):239-43.
1990: Rosenkranz H S; Ennever F K; Klopman G
Relationship between carcinogenicity in rodents and the induction of sister chromatid exchanges and chromosomal aberrations in Chinese hamster ovary cells.
Mutagenesis 1990;5(6):559-71.
1990: Rosenkranz H S; Klopman G
Evaluating the ability of CASE, an artificial intelligence structure-activity relational system, to predict structural alerts for genotoxicity.
Mutagenesis 1990;5(6):525-7.
1990: Rosenkranz H S; Klopman G
Use of a composite polyfunctional model electrophile as a probe to analyze the performance of an artificial intelligence structure-activity method.
Mutation research 1990;232(2):249-60.
1990: Rosenkranz H S; Klopman G
The structural basis of the carcinogenic and mutagenic potentials of phytoalexins.
Mutation research 1990;245(1):51-4.
1990: Rosenkranz H S; Klopman G
Prediction of the carcinogenicity in rodents of chemicals currently being tested by the US National Toxicology Program: structure-activity correlations.
Mutagenesis 1990;5(5):425-32.
1990: Rosenkranz H S; Klopman G
Novel structural concepts in elucidating the potential genotoxicity and carcinogenicity of tetrandrine, a traditional herbal drug.
Mutation research 1990;244(4):265-71.
1990: Rosenkranz H S; Klopman G
Structural alerts to genotoxicity: the interaction of human and artificial intelligence.
Mutagenesis 1990;5(4):333-61.
1990: McCoy G D; Rosenkranz H S; Klopman G
Non-mutagenic carcinogens are primarily hydrophobic.
Carcinogenesis 1990;11(7):1111-7.
1990: Klopman G; Srivastava S
Computer-automated structure evaluation of gastric antiulcer compounds: study of cytoprotective and antisecretory imidazo[1,2-a]pyridines and -pyrazines.
Molecular pharmacology 1990;37(6):958-65.
1990: Klopman G; Dimayuga M L
Computer Automated Structure Evaluation (CASE) of the teratogenicity of retinoids with the aid of a novel geometry index.
Journal of computer-aided molecular design 1990;4(2):117-30.
1990: Rosenkranz H S; Klopman G; Ohshima H; Bartsch H
Structural basis of the genotoxicity of nitrosatable phenols and derivatives present in smoked food products.
Mutation research 1990;230(1):9-27.
1990: Rosenkranz H S; Klopman G
'Cryptic' mutagens and carcinogenicity.
Mutagenesis 1990;5(2):199-202.
1990: Rosenkranz H S; Klopman G
Structural basis of the mutagenicity of 1-amino-2-naphthol-based azo dyes.
Mutagenesis 1990;5(2):137-46.
1990: Klopman G; Raychaudhury C
Vertex indices of molecular graphs in structure-activity relationships: a study of the convulsant-anticonvulsant activity of barbiturates and the carcinogenicity of unsubstituted polycyclic aromatic hydrocarbons.
Journal of chemical information and computer sciences 1990;30(1):12-9.
1990: Rosenkranz H S; Klopman G
Natural pesticides present in edible plants are predicted to be carcinogenic.
Carcinogenesis 1990;11(2):349-53.
1990: Rosenkranz H S; Klopman G
Structural basis of carcinogenicity in rodents of genotoxicants and non-genotoxicants.
Mutation research 1990;228(2):105-24.
1990: Rosenkranz H S; Klopman G
The structural basis of the mutagenicity of chemicals in Salmonella typhimurium: the National Toxicology Program Data Base.
Mutation research 1990;228(1):51-80.
1990: Klopman G; Frierson M R; Rosenkranz H S
The structural basis of the mutagenicity of chemicals in Salmonella typhimurium: the Gene-Tox data base.
Mutation research 1990;228(1):1-50.
1990: Rosenkranz H S; Ennever F K; Dimayuga M; Klopman G
Significant differences in the structural basis of the induction of sister chromatid exchanges and chromosomal aberrations in Chinese hamster ovary cells.
Environmental and molecular mutagenesis 1990;16(3):149-77.
1990: Rosenkranz H S; Klopman G
Identification of rodent carcinogens by an expert system.
Progress in clinical and biological research 1990;340B():23-48.
1990: Rosenkranz H S; Klopman G
New structural concepts for predicting carcinogenicity in rodents: an artificial intelligence approach.
Teratogenesis, carcinogenesis, and mutagenesis 1990;10(2):73-88.
1989: Rosenkranz H S; Klopman G
Structural basis of the mutagenicity of phenylazoaniline dyes.
Mutation research 1989;221(3):217-34.
1988: Rosenkranz H S; Klopman G
CASE, the computer-automated structure evaluation system, as an alternative to extensive animal testing.
Toxicology and industrial health 1988;4(4):533-40.
1988: Klopman G; Buyukbingol E
An artificial intelligence approach to the study of the structural moieties relevant to drug-receptor interactions in aldose reductase inhibitors.
Molecular pharmacology 1988;34(6):852-62.
1988: Klopman G; Dimayuga M L
Computer-automated structure evaluation of flavonoids and other structurally related compounds as glyoxalase I enzyme inhibitors.
Molecular pharmacology 1988;34(2):218-22.
1988: Rosenkranz H S; Klopman G
CASE, the computer-automated structure evaluation method, correctly predicts the low mutagenicity for Salmonella of nitrated cyclopenta-fused polycyclic aromatic hydrocarbons.
Mutation research 1988;199(1):95-101.
1987: Klopman G; Kalos A N; Rosenkranz H S
A computer automated study of the structure-mutagenicity relationships of non-fused-ring nitroarenes and related compounds.
Molecular toxicology 1987;1(1):61-81.
1986: Rosenkranz H S; Frierson M R; Klopman G
Computer-automated prediction of the mutagenicity of benzidine, 4,4"-diaminoterphenyl, 4-dimethylaminoazobenzene and 4-cyanodimethylaniline: comparison with the results of the Second UKEMS Collaborative Study.
Mutagenesis 1986;1(4):275-82.

Sign-in to see more