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Lars-Oliver Klotz

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Anna Eckers; Ayman O S El-Kadi; Charlotte Esser; Ingrit Hamann; Elisabeth Sauerbier; Peter Schroeder; Anwar Anwar-Mohamed; Lars-Oliver Klotz
Detection of a functional xenobiotic response element in a widely employed FoxO-responsive reporter construct.
Niloofar Ale-Agha; Catrin Albrecht; Lars-Oliver Klotz
Loss of gap junctional intercellular communication in rat lung epithelial cells exposed to carbon or silica-based nanoparticles.
Niloofar Ale-Agha; Catrin Albrecht; Lars-Oliver Klotz
Loss of gap junctional intercellular communication in rat lung epithelial cells exposed to quartz particles.

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2011: Anna Eckers; Ayman O S El-Kadi; Charlotte Esser; Ingrit Hamann; Elisabeth Sauerbier; Peter Schroeder; Anwar Anwar-Mohamed; Lars-Oliver Klotz
Detection of a functional xenobiotic response element in a widely employed FoxO-responsive reporter construct.
Archives of biochemistry and biophysics 2011;516(2):138-45.
2010: Niloofar Ale-Agha; Catrin Albrecht; Lars-Oliver Klotz
Loss of gap junctional intercellular communication in rat lung epithelial cells exposed to carbon or silica-based nanoparticles.
Biological chemistry 2010;391(11):1333-9.
2009: Niloofar Ale-Agha; Catrin Albrecht; Lars-Oliver Klotz
Loss of gap junctional intercellular communication in rat lung epithelial cells exposed to quartz particles.
Biochemical and biophysical research communications 2009;390(1):44-7.
2009: Niloofar Ale-Agha; Stefanie Galban; Christiane Sobieroy; Kotb Abdelmohsen; Myriam Gorospe; Helmut Sies; Lars-Oliver Klotz
HuR regulates gap junctional intercellular communication by controlling beta-catenin levels and adherens junction integrity.
Hepatology (Baltimore, Md.) 2009;50(5):1567-76.
2009: Klaus-Dietrich Kröncke; Lars-Oliver Klotz
Zinc fingers as biologic redox switches?
Antioxidants & redox signaling 2009;11(5):1015-27.
2009: Anna Eckers; Kerstin Reimann; Lars-Oliver Klotz
Nickel and copper ion-induced stress signaling in human hepatoma cells: analysis of phosphoinositide 3'-kinase/Akt signaling.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2009;22(2):307-16.
2009: Anna Eckers; Lars-Oliver Klotz
Heavy metal ion-induced insulin-mimetic signaling.
Redox report : communications in free radical research 2009;14(4):141-6.
2008: Bodo Speckmann; Philippe L Walter; Lirija Alili; Roland Reinehr; Helmut Sies; Lars-Oliver Klotz; Holger Steinbrenner
Selenoprotein P expression is controlled through interaction of the coactivator PGC-1alpha with FoxO1a and hepatocyte nuclear factor 4alpha transcription factors.
Hepatology (Baltimore, Md.) 2008;48(6):1998-2006.
2008: Jürgen Knobloch; Kerstin Reimann; Lars-Oliver Klotz; Ulrich Rüther
Thalidomide resistance is based on the capacity of the glutathione-dependent antioxidant defense.
Molecular pharmaceutics 2008;5(6):1138-44.
2008: Philippe L Walter; Holger Steinbrenner; Andreas Barthel; Lars-Oliver Klotz
Stimulation of selenoprotein P promoter activity in hepatoma cells by FoxO1a transcription factor.
Biochemical and biophysical research communications 2008;365(2):316-21.
2007: Kotb Abdelmohsen; Elisabeth Sauerbier; Niloofar Ale-Agha; Juliane Beier; Philippe Walter; Stefanie Galban; Dominik Stuhlmann; Helmut Sies; Lars-Oliver Klotz
Epidermal growth factor- and stress-induced loss of gap junctional communication is mediated by ERK-1/ERK-2 but not ERK-5 in rat liver epithelial cells.
Biochemical and biophysical research communications 2007;364(2):313-7.
2007: Andreas Barthel; Elena A Ostrakhovitch; Philippe L Walter; Andreas Kampkötter; Lars-Oliver Klotz
Stimulation of phosphoinositide 3-kinase/Akt signaling by copper and zinc ions: mechanisms and consequences.
Archives of biochemistry and biophysics 2007;463(2):175-82.
2007: Ellen Fritsche; Claudia Schäfer; Christian Calles; Thorsten Bernsmann; Thorsten Bernshausen; Melanie Wurm; Ulrike Hübenthal; Jason E Cline; Hossein Hajimiragha; Peter Schroeder; Lars-Oliver Klotz; Agneta Rannug; Peter Fürst; Helmut Hanenberg; Josef Abel; Jean Krutmann
Lightening up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B radiation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(21):8851-6.
2007: Yvonne Steffen; Tobias Jung; Lars-Oliver Klotz; Tankred Schewe; Tilman Grune; Helmut Sies
Protein modification elicited by oxidized low-density lipoprotein (LDL) in endothelial cells: protection by (-)-epicatechin.
Free radical biology & medicine 2007;42(7):955-70.
2007: Tobias Jung; Martina Engels; Lars-Oliver Klotz; Klaus-Dietrich Kröncke; Tilman Grune
Nitrotyrosine and protein carbonyls are equally distributed in HT22 cells after nitrosative stress.
Free radical biology & medicine 2007;42(6):773-86.
2006: Claudia von Montfort; Niklas S Fernau; Juliane I Beier; Helmut Sies; Lars-Oliver Klotz
Extracellular generation of hydrogen peroxide is responsible for activation of EGF receptor by ultraviolet A radiation.
Free radical biology & medicine 2006;41(9):1478-87.
2006: Philippe L Walter; Andreas Kampkötter; Anna Eckers; Andreas Barthel; Dieter Schmoll; Helmut Sies; Lars-Oliver Klotz
Modulation of FoxO signaling in human hepatoma cells by exposure to copper or zinc ions.
Archives of biochemistry and biophysics 2006;454(2):107-13.
2006: Claudia von Montfort; Victor S Sharov; Sabine Metzger; Christian Schöneich; Helmut Sies; Lars-Oliver Klotz
Singlet oxygen inactivates protein tyrosine phosphatase-1B by oxidation of the active site cysteine.
Biological chemistry 2006;387(10-11):1399-404.
2006: Anja Muller; Eniko Sonkoly; Christine Eulert; Peter Arne Gerber; Robert Kubitza; Kerstin Schirlau; Petra Franken-Kunkel; Christopher Poremba; Carl Snyderman; Lars-Oliver Klotz; Thomas Ruzicka; Henning Bier; Albert Zlotnik; Theresa L Whiteside; Bernhard Homey; Thomas K Hoffmann
Chemokine receptors in head and neck cancer: association with metastatic spread and regulation during chemotherapy.
International journal of cancer. Journal international du cancer 2006;118(9):2147-57.
2006: Juliane I Beier; Claudia von Montfort; Helmut Sies; Lars-Oliver Klotz
Activation of ErbB2 by 2-methyl-1,4-naphthoquinone (menadione) in human keratinocytes: role of EGFR and protein tyrosine phosphatases.
FEBS letters 2006;580(7):1859-64.
2005: Kotb Abdelmohsen; Claudia von Montfort; Dominik Stuhlmann; Peter Arne Gerber; Ulrich K M Decking; Helmut Sies; Lars-Oliver Klotz
Doxorubicin induces EGF receptor-dependent downregulation of gap junctional intercellular communication in rat liver epithelial cells.
Biological chemistry 2005;386(3):217-23.
2005: Andreas Barthel; Lars-Oliver Klotz
Phosphoinositide 3-kinase signaling in the cellular response to oxidative stress.
Biological chemistry 2005;386(3):207-16.
2005: Ira Melchheier; Claudia von Montfort; Dominik Stuhlmann; Helmut Sies; Lars-Oliver Klotz
Quinone-induced Cdc25A inhibition causes ERK-dependent connexin phosphorylation.
Biochemical and biophysical research communications 2005;327(4):1016-23.
2005: Kotb Abdelmohsen; Dominik Stuhlmann; Felicitas Daubrawa; Lars-Oliver Klotz
Dicumarol is a potent reversible inhibitor of gap junctional intercellular communication.
Archives of biochemistry and biophysics 2005;434(2):241-7.
2005: Peter Schroeder; Nina Voevodskaya; Lars-Oliver Klotz; Peter Brenneisen; Astrid Gräslund; Helmut Sies
Loss of the tyrosyl radical in mouse ribonucleotide reductase by (-)-epicatechin.
Biochemical and biophysical research communications 2005;326(3):614-7.
2004: Stefan M Schieke; Claudia von Montfort; Darius P Buchczyk; Andreas Timmer; Susanne Grether-Beck; Jean Krutmann; Nikki J Holbrook; Lars-Oliver Klotz
Singlet oxygen-induced attenuation of growth factor signaling: possible role of ceramides.
Free radical research 2004;38(7):729-37.
2004: Ulrich Flögel; Axel Gödecke; Lars-Oliver Klotz; Jürgen Schrader
Role of myoglobin in the antioxidant defense of the heart.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(10):1156-8.
2004: André Mahns; Rainer Wolber; Franz Stäb; Lars-Oliver Klotz; Helmut Sies
Contribution of UVB and UVA to UV-dependent stimulation of cyclooxygenase-2 expression in artificial epidermis.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2004;3(3):257-62.
2004: Henrik Traulsen; Holger Steinbrenner; Darius P Buchczyk; Lars-Oliver Klotz; Helmut Sies
Selenoprotein P protects low-density lipoprotein against oxidation.
Free radical research 2004;38(2):123-8.
2004: Ritsuko Yamauchi; Akimichi Morita; Yoko Yasuda; Susanne Grether-Beck; Lars-Oliver Klotz; Takuo Tsuji; Jean Krutmann
Different susceptibility of malignant versus nonmalignant human T cells toward ultraviolet A-1 radiation-induced apoptosis.
The Journal of investigative dermatology 2004;122(2):477-83.
2004: Kotb Abdelmohsen; Pauline Patak; Claudia von Montfort; Ira Melchheier; Helmut Sies; Lars-Oliver Klotz
Signaling effects of menadione: from tyrosine phosphatase inactivation to connexin phosphorylation.
Methods in enzymology 2004;378():258-72.
2003: Kotb Abdelmohsen; Peter Arne Gerber; Claudia von Montfort; Helmut Sies; Lars-Oliver Klotz
Epidermal growth factor receptor is a common mediator of quinone-induced signaling leading to phosphorylation of connexin-43: role of glutathione and tyrosine phosphatases.
The Journal of biological chemistry 2003;278(40):38360-7.
2003: Govindasamy Mugesh; Lars-Oliver Klotz; Wolf-Walther du Mont; Katja Becker; Helmut Sies
Selenenyl iodide: a new substrate for mammalian thioredoxin reductase.
Organic & biomolecular chemistry 2003;1(16):2848-52.
2003: Peter Schroeder; Lars-Oliver Klotz; Helmut Sies
Amphiphilic properties of (-)-epicatechin and their significance for protection of cells against peroxynitrite.
Biochemical and biophysical research communications 2003;307(1):69-73.
2003: Christoph V Suschek; Oliver Schnorr; Karsten Hemmrich; Olivier Aust; Lars-Oliver Klotz; Helmut Sies; Victoria Kolb-Bachofen
Critical role of L-arginine in endothelial cell survival during oxidative stress.
Circulation 2003;107(20):2607-14.
2003: Lars-Oliver Klotz; Klaus-Dietrich Kröncke; Darius P Buchczyk; Helmut Sies
Role of copper, zinc, selenium and tellurium in the cellular defense against oxidative and nitrosative stress.
The Journal of nutrition 2003;133(5 Suppl 1):1448S-51S.
2003: Lars-Oliver Klotz; Helmut Sies
Defenses against peroxynitrite: selenocompounds and flavonoids.
Toxicology letters 2003;140-141():125-32.
2003: André Mahns; Ira Melchheier; Christoph V Suschek; Helmut Sies; Lars-Oliver Klotz
Irradiation of cells with ultraviolet-A (320-400 nm) in the presence of cell culture medium elicits biological effects due to extracellular generation of hydrogen peroxide.
Free radical research 2003;37(4):391-7.
2003: Darius P Buchczyk; Tilman Grune; Helmut Sies; Lars-Oliver Klotz
Modifications of glyceraldehyde-3-phosphate dehydrogenase induced by increasing concentrations of peroxynitrite: early recognition by 20S proteasome.
Biological chemistry 2003;384(2):237-41.
2003: Claudio Jösch; Lars-Oliver Klotz; Helmut Sies
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
Biological chemistry 2003;384(2):213-8.
2003: Lars-Oliver Klotz; Klaus-Dietrich Kröncke; Helmut Sies
Singlet oxygen-induced signaling effects in mammalian cells.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2003;2(2):88-94.
2003: Andreas Kampkötter; Thorsten E Volkmann; Sarah Hegi de Castro; Britta Leiers; Lars-Oliver Klotz; Thomas Johnson; Christopher D Link; Kimberly Henkle-Dührsen
Functional analysis of the glutathione S-transferase 3 from Onchocerca volvulus (Ov-GST-3): a parasite GST confers increased resistance to oxidative stress in Caenorhabditis elegans.
Journal of molecular biology 2003;325(1):25-37.
2002: Lars-Oliver Klotz; Peter Schroeder; Helmut Sies
Peroxynitrite signaling: receptor tyrosine kinases and activation of stress-responsive pathways.
Free radical biology & medicine 2002;33(6):737-43.
2002: Lars-Oliver Klotz; Pauline Patak; Niloofar Ale-Agha; Darius P Buchczyk; Kotb Abdelmohsen; Peter Arne Gerber; Claudia von Montfort; Helmut Sies
2-Methyl-1,4-naphthoquinone, vitamin K(3), decreases gap-junctional intercellular communication via activation of the epidermal growth factor receptor/extracellular signal-regulated kinase cascade.
Cancer research 2002;62(17):4922-8.
2002: Klaus-Dietrich Kröncke; Lars-Oliver Klotz; Christoph V Suschek; Helmut Sies
Comparing nitrosative versus oxidative stress toward zinc finger-dependent transcription. Unique role for NO.
The Journal of biological chemistry 2002;277(15):13294-301.
2002: Lars-Oliver Klotz
Oxidant-induced signaling: effects of peroxynitrite and singlet oxygen.
Biological chemistry 2002;383(3-4):443-56.
2002: Elena A Ostrakhovitch; Mohammad Reza Lordnejad; Freimut Schliess; Helmut Sies; Lars-Oliver Klotz
Copper ions strongly activate the phosphoinositide-3-kinase/Akt pathway independent of the generation of reactive oxygen species.
Archives of biochemistry and biophysics 2002;397(2):232-9.
2002: Lars-Oliver Klotz; Helmut Sies
Reversible conversion of nitroxyl anion to nitric oxide.
Methods in enzymology 2002;349():101-6.
2002: Gavin E Arteel; Lars-Oliver Klotz; Darius P Buchczyk; Helmut Sies
Selenoprotein P.
Methods in enzymology 2002;347():121-5.
2001: Peter Schroeder; H Zhang; Lars-Oliver Klotz; B Kalyanaraman; Helmut Sies
(-)-Epicatechin inhibits nitration and dimerization of tyrosine in hydrophilic as well as hydrophobic environments.
Biochemical and biophysical research communications 2001;289(5):1334-8.
2001: Tankred Schewe; Christian Sadik; Lars-Oliver Klotz; T Yoshimoto; H Kühn; Helmut Sies
Polyphenols of cocoa: inhibition of mammalian 15-lipoxygenase.
Biological chemistry 2001;382(12):1687-96.
2001: Peter Schroeder; Lars-Oliver Klotz; Darius P Buchczyk; Christian Sadik; Tankred Schewe; Helmut Sies
Epicatechin selectively prevents nitration but not oxidation reactions of peroxynitrite.
Biochemical and biophysical research communications 2001;285(3):782-7.
2001: Darius P Buchczyk; Lars-Oliver Klotz; K Lang; Clemens Fritsch; Helmut Sies
High efficiency of 5-aminolevulinate-photodynamic treatment using UVA irradiation.
Carcinogenesis 2001;22(6):879-83.
2001: KD McCullough; Jennifer L Martindale; Lars-Oliver Klotz; T Y Aw; Nikki J Holbrook
Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state.
Molecular and cellular biology 2001;21(4):1249-59.
2001: Lars-Oliver Klotz; Nikki J Holbrook; Helmut Sies
UVA and singlet oxygen as inducers of cutaneous signaling events.
Current problems in dermatology 2001;29():95-113.
2000: Lars-Oliver Klotz; Stefan M Schieke; Helmut Sies; Nikki J Holbrook
Peroxynitrite activates the phosphoinositide 3-kinase/Akt pathway in human skin primary fibroblasts.
The Biochemical journal 2000;352 Pt 1():219-25.
2000: Dmitry B Zorov; C R Filburn; Lars-Oliver Klotz; Jay L Zweier; STEVEN SOLLOTT
Reactive oxygen species (ROS)-induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes.
The Journal of experimental medicine 2000;192(7):1001-14.
1999: Stefan M Schieke; K Briviba; Lars-Oliver Klotz; Helmut Sies
Activation pattern of mitogen-activated protein kinases elicited by peroxynitrite: attenuation by selenite supplementation.
FEBS letters 1999;448(2-3):301-3.
1999: K Briviba; Lars-Oliver Klotz; Helmut Sies
Defenses against peroxynitrite.
Methods in enzymology 1999;301():301-11.
1998: Lars-Oliver Klotz; Clemens Fritsch; K Briviba; N Tsacmacidis; F Schliess; Helmut Sies
Activation of JNK and p38 but not ERK MAP kinases in human skin cells by 5-aminolevulinate-photodynamic therapy.
Cancer research 1998;58(19):4297-300.
1998: K Briviba; R Tamler; Lars-Oliver Klotz; Lars Engman; Ian A Cotgreave; Helmut Sies
Protection by organotellurium compounds against peroxynitrite-mediated oxidation and nitration reactions.
Biochemical pharmacology 1998;55(6):817-23.
1998: Helmut Sies; Lars-Oliver Klotz; VS Sharov; A Assmann; K Briviba
Protection against peroxynitrite by selenoproteins.
Zeitschrift für Naturforschung. C, Journal of biosciences 1998;53(3-4):228-32.
1998: Peter Brenneisen; Jutta Wenk; Lars-Oliver Klotz; Meinhard Wlaschek; K Briviba; Thomas Krieg; H Sies; Karin Scharffetter-Kochanek
Central role of Ferrous/Ferric iron in the ultraviolet B irradiation-mediated signaling pathway leading to increased interstitial collagenase (matrix-degrading metalloprotease (MMP)-1) and stromelysin-1 (MMP-3) mRNA levels in cultured human dermal fibroblasts.
The Journal of biological chemistry 1998;273(9):5279-87.
1997: A Morita; T Werfel; Helger Stege; C Ahrens; K Karmann; Markus Grewe; Susanne Grether-Beck; Thomas Ruzicka; A Kapp; Lars-Oliver Klotz; Helmut Sies; Jean Krutmann
Evidence that singlet oxygen-induced human T helper cell apoptosis is the basic mechanism of ultraviolet-A radiation phototherapy.
The Journal of experimental medicine 1997;186(10):1763-8.
1997: K Briviba; Lars-Oliver Klotz; Helmut Sies
Toxic and signaling effects of photochemically or chemically generated singlet oxygen in biological systems.
Biological chemistry 1997;378(11):1259-65.
1997: Helmut Sies; VS Sharov; Lars-Oliver Klotz; K Briviba
Glutathione peroxidase protects against peroxynitrite-mediated oxidations. A new function for selenoproteins as peroxynitrite reductase.
The Journal of biological chemistry 1997;272(44):27812-7.
1997: OM Panasenko; K Briviba; Lars-Oliver Klotz; Helmut Sies
Oxidative modification and nitration of human low-density lipoproteins by the reaction of hypochlorous acid with nitrite.
Archives of biochemistry and biophysics 1997;343(2):254-9.
1997: Lars-Oliver Klotz; K Briviba; Helmut Sies
Singlet oxygen mediates the activation of JNK by UVA radiation in human skin fibroblasts.
FEBS letters 1997;408(3):289-91.