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Ruth Kluck

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Chemicals & Drugs

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Publications

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Peter Czabotar; Grant Dewson; W Douglas Fairlie; Colin Hockings; David C S Huang; Ruth M Kluck; Erinna Lee; Stephen Ma; Adeline Y Robin; Brian J Smith; Dana Westphal; Shenggen Yao; Jerry M Adams; Peter M Colman
Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis.
V H Tran; D Westphal; A Alsop; R Bartolo; Grant Dewson; Ruth M Kluck
Bak apoptotic function is not directly regulated by phosphorylation.
Grant Dewson; P Frederick; C Hockings; Tobias Kratina; S Ma; I Tan; Ruth M Kluck
Bax dimerizes via a symmetric BH3:groove interface during apoptosis.

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All Publications

2013: Peter Czabotar; Grant Dewson; W Douglas Fairlie; Colin Hockings; David C S Huang; Ruth M Kluck; Erinna Lee; Stephen Ma; Adeline Y Robin; Brian J Smith; Dana Westphal; Shenggen Yao; Jerry M Adams; Peter M Colman
Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis.
Cell 2013;152(3):519-31.
2013: V H Tran; D Westphal; A Alsop; R Bartolo; Grant Dewson; Ruth M Kluck
Bak apoptotic function is not directly regulated by phosphorylation.
Cell death & disease 2013;4():e452.
2012: Grant Dewson; P Frederick; C Hockings; Tobias Kratina; S Ma; I Tan; Ruth M Kluck
Bax dimerizes via a symmetric BH3:groove interface during apoptosis.
Cell death and differentiation 2012;19(4):661-70.
2012: V R Sutton; J A Trapani; P I Bird; M E Christensen; Grant Dewson; R W Johnstone; Ruth M Kluck; Karin A Sedelies; N J Waterhouse
Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737.
Cell death & disease 2012;3():e344.
2012: Pedro Eitz Ferrer; Paul Frederick; Jacqueline M Gulbis; Grant Dewson; Ruth M Kluck
Translocation of a Bak C-terminus mutant from cytosol to mitochondria to mediate cytochrome C release: implications for Bak and Bax apoptotic function.
PloS one 2012;7(3):e31510.
2009: Grant Dewson; Tobias Kratina; Peter Czabotar; Catherine L Day; Jerry M Adams; Ruth M Kluck
Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices.
Molecular cell 2009;36(4):696-703.
2009: Grant Dewson; Ruth M Kluck
Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis.
Journal of cell science 2009;122(Pt 16):2801-8.
2008: Danielle J Smith; Heling Ng; Ruth M Kluck; Phillip Nagley
The mitochondrial gateway to cell death.
IUBMB life 2008;60(6):383-9.
2008: Grant Dewson; Tobias Kratina; Huiyan W Sim; Hamsa Puthalakath; Jerry M Adams; Peter M Colman; Ruth M Kluck
To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.
Molecular cell 2008;30(3):369-80.
2007: Rachel Uren; Grant Dewson; Lin Chen; Stephanie C Coyne; David C S Huang; Jerry M Adams; Ruth M Kluck
Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak.
The Journal of cell biology 2007;177(2):277-87.
2007: Simon N Willis; Jamie I Fletcher; Thomas Kaufmann; Mark F Van Delft; Lin Chen; Peter Czabotar; Helen Ierino; Erinna Lee; W Douglas Fairlie; Philippe Bouillet; Andreas Strasser; Ruth M Kluck; Jerry M Adams; David C S Huang
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.
Science (New York, N.Y.) 2007;315(5813):856-9.
2005: Rachel Uren; Grant Dewson; Christine Bonzon; Trevor Lithgow; Donald D Newmeyer; Ruth M Kluck
Mitochondrial release of pro-apoptotic proteins: electrostatic interactions can hold cytochrome c but not Smac/DIABLO to mitochondrial membranes.
The Journal of biological chemistry 2005;280(3):2266-74.
2004: Nigel Waterhouse; Rohan Steel; Ruth M Kluck; Joseph A Trapani
Assaying cytochrome C translocation during apoptosis.
Methods in molecular biology (Clifton, N.J.) 2004;284():307-13.
2002: Ziedulla Kh Abdullaev; Marina E Bodrova; Boris V Chernyak; Dmitry A Dolgikh; Ruth M Kluck; Mikhail O Pereverzev; Alexander S Arseniev; Roman G Efremov; Mikhail P Kirpichnikov; Elena N Mokhova; Donald D Newmeyer; Heinrich Roder; Vladimir P Skulachev
A cytochrome c mutant with high electron transfer and antioxidant activities but devoid of apoptogenic effect.
The Biochemical journal 2002;362(Pt 3):749-54.
2001: AA Kaspar; Satoshi Okada; J Kumar; Francis Poulain; Katerina A Drouvalakis; A Kelekar; DA Hanson; Ruth M Kluck; Yasumichi Hitoshi; D E Johnson; C J Froelich; Craig Thompson; Donald D Newmeyer; Alberto Anel; Carol Clayberger; Alan Krensky
A distinct pathway of cell-mediated apoptosis initiated by granulysin.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(1):350-6.
2001: Nigel Waterhouse; Joshua C Goldstein; Ruth M Kluck; Donald D Newmeyer; Douglas R Green
The (Holey) study of mitochondria in apoptosis.
Methods in cell biology 2001;66():365-91.
2000: O von Ahsen; Christian Renken; Guy Perkins; Ruth M Kluck; Ella Bossy-Wetzel; Donald D Newmeyer
Preservation of mitochondrial structure and function after Bid- or Bax-mediated cytochrome c release.
The Journal of cell biology 2000;150(5):1027-36.
2000: Ruth M Kluck; Lisa M Ellerby; H Michael Ellerby; S Naiem; M P Yaffe; E Margoliash; Dale E Bredesen; A G Mauk; F Sherman; Donald D Newmeyer
Determinants of cytochrome c pro-apoptotic activity. The role of lysine 72 trimethylation.
The Journal of biological chemistry 2000;275(21):16127-33.
2000: Donald D Newmeyer; Ella Bossy-Wetzel; Ruth M Kluck; BB Wolf; Helen M Beere; Douglas R Green
Bcl-xL does not inhibit the function of Apaf-1.
Cell death and differentiation 2000;7(4):402-7.
2000: Joshua C Goldstein; Ruth M Kluck; Douglas R Green
A single cell analysis of apoptosis. Ordering the apoptotic phenotype.
Annals of the New York Academy of Sciences 2000;926():132-41.
1999: Ruth M Kluck; Mauro Degli Esposti; Guy Perkins; Christian Renken; Tomomi Kuwana; Ella Bossy-Wetzel; M Goldberg; T Allen; M J Barber; Douglas R Green; Donald D Newmeyer
The pro-apoptotic proteins, Bid and Bax, cause a limited permeabilization of the mitochondrial outer membrane that is enhanced by cytosol.
The Journal of cell biology 1999;147(4):809-22.
1999: EA Slee; M T Harte; Ruth M Kluck; BB Wolf; C A Casiano; Donald D Newmeyer; Hong-Gang Wang; John C Reed; D W Nicholson; E S Alnemri; Douglas R Green; Seamus Martin
Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner.
The Journal of cell biology 1999;144(2):281-92.
1997: Ruth M Kluck; Seamus Martin; B M Hoffman; J S Zhou; Douglas R Green; Donald D Newmeyer
Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system.
The EMBO journal 1997;16(15):4639-49.
1997: Ruth M Kluck; Ella Bossy-Wetzel; Douglas R Green; Donald D Newmeyer
The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis.
Science (New York, N.Y.) 1997;275(5303):1132-6.
1997: Ruth M Kluck; S Kasibhatla
A lively meeting on a deathly topic.
Apoptosis : an international journal on programmed cell death 1997;2(3):337-42.