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Jochen Klucken

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Wei Xiang; Marvin Berlinghof; Julia C Bussmann; Stefan Helling; Jochen Klucken; Katrin Marcus; Tilman E Schäffer; Johannes C M Schlachetzki; Jürgen Winkler; Cord-Michael Becker
Oxidative stress-induced posttranslational modifications of alpha-synuclein: specific modification of alpha-synuclein by 4-hydroxy-2-nonenal increases dopaminergic toxicity.
Jochen Klucken; Zacharias Kohl; Patrick Kugler; Franz Marxreiter; Johannes Schlachetzki; Ralph Steidl; Jens Barth; Bjoern Eskofier; Thore Henze; Joachim Hornegger; Juergen Winkler
Unbiased and mobile gait analysis detects motor impairment in Parkinson's disease.
Jochen Klucken; Eliezer Masliah; Pamela J McLean; Silke Nuber; Anne-Maria Poehler; Edward Rockenstein; Ursula Schlötzer-Schrehardt; Jacqueline Schneider; Darius Ebrahimi-Fakhari; Bradley T Hyman; Juergen Winkler
Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway.

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All Publications

2013: Wei Xiang; Marvin Berlinghof; Julia C Bussmann; Stefan Helling; Jochen Klucken; Katrin Marcus; Tilman E Schäffer; Johannes C M Schlachetzki; Jürgen Winkler; Cord-Michael Becker
Oxidative stress-induced posttranslational modifications of alpha-synuclein: specific modification of alpha-synuclein by 4-hydroxy-2-nonenal increases dopaminergic toxicity.
Molecular and cellular neurosciences 2013;54():71-83.
2013: Jochen Klucken; Zacharias Kohl; Patrick Kugler; Franz Marxreiter; Johannes Schlachetzki; Ralph Steidl; Jens Barth; Bjoern Eskofier; Thore Henze; Joachim Hornegger; Juergen Winkler
Unbiased and mobile gait analysis detects motor impairment in Parkinson's disease.
PloS one 2013;8(2):e56956.
2012: Jochen Klucken; Eliezer Masliah; Pamela J McLean; Silke Nuber; Anne-Maria Poehler; Edward Rockenstein; Ursula Schlötzer-Schrehardt; Jacqueline Schneider; Darius Ebrahimi-Fakhari; Bradley T Hyman; Juergen Winkler
Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway.
Autophagy 2012;8(5):754-66.
2012: Hagen B Huttner; Roland Coras; Denis Corbeil; Arnd Doerfler; Hajo M Hamer; Stephan P Kloska; Jochen Klucken; Martin Köhrmann; Joji B Kuramatsu; Christoph Mauer; Elisabeth Pauli; Stefan Schwab; Christina Thirmeyer; Daniel Weigel; Jürgen Winkler; Burkhard S Kasper
Increased membrane shedding--indicated by an elevation of CD133-enriched membrane particles--into the CSF in partial epilepsy.
Epilepsy research 2012;99(1-2):101-6.
2012: Jens Barth; Katharina Bergner; Jochen Klucken; Gerald Schickhuber; Jürgen Winkler; Michael Sünkel; Björn Eskofier
Combined analysis of sensor data from hand and gait motor function improves automatic recognition of Parkinson's disease.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2012;2012():5122-5.
2011: Carolin Moessnang; Gabriele Frank; Ulrich Bogdahn; Jurgen Winkler; Mark W. Greenlee; Jochen Klucken
Altered activation patterns within the olfactory network in Parkinson's disease.
Cerebral cortex (New York, N.Y. : 1991) 2011;21(6):1246-53.
2011: Jens Barth; Joachim Hornegger; Thomas Kammerer; Jochen Klucken; Patrick Kugler; Ralph Steidl; Jürgen Winkler; Björn Eskofier
Biometric and mobile gait analysis for early diagnosis and therapy monitoring in Parkinson's disease.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2011;2011():868-71.
2009: Beate Winner; Paula Desplats; Christian Hagl; Jochen Klucken; Robert Aigner; Sonja Ploetz; Jörn Laemke; Alexandra Karl; Ludwig Aigner; Eliezer Masliah; Erich Buerger; Jürgen Winkler
Dopamine receptor activation promotes adult neurogenesis in an acute Parkinson model.
Experimental neurology 2009;219(2):543-52.
2009: Franz Marxreiter; Silke Nuber; Mahesh Kandasamy; Jochen Klucken; Robert Aigner; Ralf Burgmayer; Sebastien Couillard-Despres; Olaf Riess; Jürgen Winkler; Beate Winner
Changes in adult olfactory bulb neurogenesis in mice expressing the A30P mutant form of alpha-synuclein.
The European journal of neuroscience 2009;29(5):879-90.
2009: Tiago Outeiro; Jochen Klucken; Kathryn Bercury; Julie Tetzlaff; Preeti Putcha; Luis M A Oliveira; Alexandre Quintas; Pamela J McLean; Bradley T Hyman
Dopamine-induced conformational changes in alpha-synuclein.
PloS one 2009;4(9):e6906.
2008: Heinrich J Audebert; Sandra Boy; Ralf Jankovits; Philipp Pilz; Jochen Klucken; Nando P Fehm; Johannes Schenkel
Is mobile teleconsulting equivalent to hospital-based telestroke services?
Stroke; a journal of cerebral circulation 2008;39(12):3427-30.
2007: Jessie L St Martin; Jochen Klucken; Tiago Outeiro; Paul Nguyen; Christine Keller-McGandy; Ippolita Cantuti-Castelvetri; Tom N Grammatopoulos; David G Standaert; Bradley T Hyman; Pamela J McLean
Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra.
Journal of neurochemistry 2007;100(6):1449-57.
2006: Tiago Outeiro; Jochen Klucken; Katherine E Strathearn; Fang Liu; Paul Nguyen; Jean-Christophe Rochet; Bradley T Hyman; Pamela J McLean
Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation.
Biochemical and biophysical research communications 2006;351(3):631-8.
2006: Jochen Klucken; Tiago Outeiro; Paul Nguyen; Pamela J McLean; Bradley T Hyman
Detection of novel intracellular alpha-synuclein oligomeric species by fluorescence lifetime imaging.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(12):2050-7.
2006: Jochen Klucken; Martin Ingelsson; Youngah Shin; Michael C Irizarry; E Tessa Hedley-Whyte; M Frosch; John H Growdon; Pamela J McLean; Bradley T Hyman
Clinical and biochemical correlates of insoluble alpha-synuclein in dementia with Lewy bodies.
Acta neuropathologica 2006;111(2):101-8.
2005: Ippolita Cantuti-Castelvetri; Jochen Klucken; Martin Ingelsson; Karunya Ramasamy; Pamela J McLean; Matthew P Frosch; Bradley T Hyman; David G Standaert
Alpha-synuclein and chaperones in dementia with Lewy bodies.
Journal of neuropathology and experimental neurology 2005;64(12):1058-66.
2005: Jung Lee; Hiroaki Fukumoto; Jennifer Orne; Jochen Klucken; Susan Raju; Charles R Vanderburg; Michael C Irizarry; Bradley T Hyman; Martin Ingelsson
Decreased levels of BDNF protein in Alzheimer temporal cortex are independent of BDNF polymorphisms.
Experimental neurology 2005;194(1):91-6.
2005: Youngah Shin; Jochen Klucken; Winston Patterson; Bradley T Hyman; Pamela J McLean
The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways.
The Journal of biological chemistry 2005;280(25):23727-34.
2004: Jochen Klucken; Youngah Shin; Bradley T Hyman; Pamela J McLean
A single amino acid substitution differentiates Hsp70-dependent effects on alpha-synuclein degradation and toxicity.
Biochemical and biophysical research communications 2004;325(1):367-73.
2004: Pamela J McLean; Jochen Klucken; Youngah Shin; Bradley T Hyman
Geldanamycin induces Hsp70 and prevents alpha-synuclein aggregation and toxicity in vitro.
Biochemical and biophysical research communications 2004;321(3):665-9.
2004: Jochen Klucken; Youngah Shin; Eliezer Masliah; Bradley T Hyman; Pamela J McLean
Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity.
The Journal of biological chemistry 2004;279(24):25497-502.
2003: Jochen Klucken; Pamela J McLean; E Gomez-Tortosa; Martin Ingelsson; Bradley T Hyman
Neuritic alterations and neural system dysfunction in Alzheimer's disease and dementia with Lewy bodies.
Neurochemical research 2003;28(11):1683-91.
2003: Frank-Peter Wachs; Sebastien Couillard-Despres; Maren Engelhardt; Daniel Wilhelm; Sonja Ploetz; Maurice Vroemen; Johanna Kaesbauer; Gökhan Uyanik; Jochen Klucken; Claudia Karl; Johanna Tebbing; Clive Svendsen; Norbert Weidner; H Georg Kuhn; Jürgen Winkler; Ludwig Aigner
High efficacy of clonal growth and expansion of adult neural stem cells.
Laboratory investigation; a journal of technical methods and pathology 2003;83(7):949-62.
2000: Thomas Langmann; Mustafa Porsch-Ozcürümez; U Unkelbach; Jochen Klucken; Gerd Schmitz
Genomic organization and characterization of the promoter of the human ATP-binding cassette transporter-G1 (ABCG1) gene.
Biochimica et biophysica acta 2000;1494(1-2):175-80.
2000: Wolfgang E Kaminski; Evelyn Orsó; W Diederich; Jochen Klucken; Wolfgang Drobnik; Gerd Schmitz
Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7).
Biochemical and biophysical research communications 2000;273(2):532-8.
2000: Jochen Klucken; Christa Büchler; Evelyn Orsó; Wolfgang E Kaminski; Mustafa Porsch-Ozcürümez; Gerhard Liebisch; M Kapinsky; W Diederich; Wolfgang Drobnik; M Dean; R Allikmets; Gerd Schmitz
ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(2):817-22.
2000: Christa Buechler; Mirko Ritter; Evelyn Orsó; Thomas Langmann; Jochen Klucken; Gerd Schmitz
Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli.
Journal of leukocyte biology 2000;67(1):97-103.
1999: Marek Bodzioch; Evelyn Orsó; Jochen Klucken; Thomas Langmann; Alfred Böttcher; W Diederich; Wolfgang Drobnik; Stefan Barlage; Christa Büchler; Mustafa Porsch-Ozcürümez; Wolfgang E Kaminski; H W Hahmann; K Oette; Gregor Rothe; Charalampos Aslanidis; Karl J Lackner; Gerd Schmitz
The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease.
Nature genetics 1999;22(4):347-51.
1999: Thomas Langmann; Jochen Klucken; Markus Reil; Gerhard Liebisch; M F Luciani; Giovanna Chimini; Wolfgang E Kaminski; Gerd Schmitz
Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1): evidence for sterol-dependent regulation in macrophages.
Biochemical and biophysical research communications 1999;257(1):29-33.
1999: Mirko Ritter; Christa Buechler; Thomas Langmann; E Orso; Jochen Klucken; Gerd Schmitz
The scavenger receptor CD163: regulation, promoter structure and genomic organization.
Pathobiology : journal of immunopathology, molecular and cellular biology 1999;67(5-6):257-61.
1999: Gerd Schmitz; Wolfgang E Kaminski; Mustafa Porsch-Ozcürümez; Jochen Klucken; Evelyn Orsó; Marek Bodzioch; Christa Büchler; Wolfgang Drobnik
ATP-binding cassette transporter A1 (ABCA1) in macrophages: a dual function in inflammation and lipid metabolism?
Pathobiology : journal of immunopathology, molecular and cellular biology 1999;67(5-6):236-40.
1997: Gerd Schmitz; Evelyn Orsó; Gregor Rothe; Jochen Klucken
Scavenging, signalling and adhesion coupling in macrophages: implications for atherogenesis.
Current opinion in lipidology 1997;8(5):287-300.
1996: Gregor Rothe; H Gabriel; E Kovacs; Jochen Klucken; J Stöhr; W Kindermann; Gerd Schmitz
Peripheral blood mononuclear phagocyte subpopulations as cellular markers in hypercholesterolemia.
Arteriosclerosis, thrombosis, and vascular biology 1996;16(12):1437-47.