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Tania Baker

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequence

Living Beings

Phenomena

Protein Binding

Physiology

Protein Folding

Disorders

Protein Denaturation

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Network (preview)

Co-Publications
Name
51
Sauer, Robert
13
Levchenko, Igor
8
Grant, Robert
7
Flynn, Julia
7
Burton, Randall
7
Bolon, Daniel N.
6
Neher, Saskia
5
Hersch, Greg
5
Burton, Briana
5
Wah, David
5
Williams, Tanya
5
Martin, Andreas
4
Siddiqui, Samia
4
Kenniston, Jon
4
Kim, Yong In

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Publications

TOP 3
Glynn Steven E; Martin Andreas; Nager Andrew R; Baker Tania A; Sauer Robert T
Structures of asymmetric ClpX hexamers reveal nucleotide-dependent motions in a AAA+ protein-unfolding machine.
Pruteanu Mihaela; Baker Tania A
Proteolysis in the SOS response and metal homeostasis in Escherichia coli.
Barkow Sarah R; Levchenko Igor; Baker Tania A; Sauer Robert T
Polypeptide translocation by the AAA+ ClpXP protease machine.

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All Publications

2009: Glynn Steven E; Martin Andreas; Nager Andrew R; Baker Tania A; Sauer Robert T
Structures of asymmetric ClpX hexamers reveal nucleotide-dependent motions in a AAA+ protein-unfolding machine.
Cell 2009;139(4):744-56.
2009: Pruteanu Mihaela; Baker Tania A
Proteolysis in the SOS response and metal homeostasis in Escherichia coli.
Research in microbiology 2009;160(9):677-83.
2009: Barkow Sarah R; Levchenko Igor; Baker Tania A; Sauer Robert T
Polypeptide translocation by the AAA+ ClpXP protease machine.
Chemistry & biology 2009;16(6):605-12.
2009: Román-Hernández Giselle; Grant Robert A; Sauer Robert T; Baker Tania A
Molecular basis of substrate selection by the N-end rule adaptor protein ClpS.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(22):8888-93.
2009: Pruteanu Mihaela; Baker Tania A
Controlled degradation by ClpXP protease tunes the levels of the excision repair protein UvrA to the extent of DNA damage.
Molecular microbiology 2009;71(4):912-24.
2008: Wang Kevin H; Roman-Hernandez Giselle; Grant Robert A; Sauer Robert T; Baker Tania A
The molecular basis of N-end rule recognition.
Molecular cell 2008;32(3):406-14.
2008: Martin Andreas; Baker Tania A; Sauer Robert T
Pore loops of the AAA+ ClpX machine grip substrates to drive translocation and unfolding.
Nature structural & molecular biology 2008;15(11):1147-51.
2008: Wang Kevin H; Oakes Elizabeth S C; Sauer Robert T; Baker Tania A
Tuning the strength of a bacterial N-end rule degradation signal.
The Journal of biological chemistry 2008;283(36):24600-7.
2008: Schweidenback Caterina T H; Baker Tania A
Dissecting the roles of MuB in Mu transposition: ATP regulation of DNA binding is not essential for target delivery.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(34):12101-7.
2008: Moore Sean D; Baker Tania A; Sauer Robert T
Forced extraction of targeted components from complex macromolecular assemblies.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(33):11685-90.
2008: Yakamavich Joseph A; Baker Tania A; Sauer Robert T
Asymmetric nucleotide transactions of the HslUV protease.
Journal of molecular biology 2008;380(5):946-57.
2008: Abdelhakim Aliaa H; Oakes Elizabeth C; Sauer Robert T; Baker Tania A
Unique contacts direct high-priority recognition of the tetrameric Mu transposase-DNA complex by the AAA+ unfoldase ClpX.
Molecular cell 2008;30(1):39-50.
2008: Martin Andreas; Baker Tania A; Sauer Robert T
Diverse pore loops of the AAA+ ClpX machine mediate unassisted and adaptor-dependent recognition of ssrA-tagged substrates.
Molecular cell 2008;29(4):441-50.
2007: Baker Tania A
Obituary: Arthur Kornberg (1918-2007).
Nature 2007;450(7171):809.
2007: Lemberg Kathryn M; Schweidenback Caterina T H; Baker Tania A
The dynamic Mu transpososome: MuB activation prevents disintegration.
Journal of molecular biology 2007;374(5):1158-71.
2007: Chien Peter; Grant Robert A; Sauer Robert T; Baker Tania A
Structure and substrate specificity of an SspB ortholog: design implications for AAA+ adaptors.
Structure (London, England : 1993) 2007;15(10):1296-305.
2007: Martin Andreas; Baker Tania A; Sauer Robert T
Distinct static and dynamic interactions control ATPase-peptidase communication in a AAA+ protease.
Molecular cell 2007;27(1):41-52.
2007: Chien Peter; Perchuk Barrett S; Laub Michael T; Sauer Robert T; Baker Tania A
Direct and adaptor-mediated substrate recognition by an essential AAA+ protease.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(16):6590-5.
2007: McGinness Kathleen E; Bolon Daniel N; Kaganovich Mark; Baker Tania A; Sauer Robert T
Altered tethering of the SspB adaptor to the ClpXP protease causes changes in substrate delivery.
The Journal of biological chemistry 2007;282(15):11465-73.
2007: Pruteanu Mihaela; Neher Saskia B; Baker Tania A
Ligand-controlled proteolysis of the Escherichia coli transcriptional regulator ZntR.
Journal of bacteriology 2007;189(8):3017-25.
2007: Wang Kevin H; Sauer Robert T; Baker Tania A
ClpS modulates but is not essential for bacterial N-end rule degradation.
Genes & development 2007;21(4):403-8.
2007: Farrell Christopher M; Baker Tania A; Sauer Robert T
Altered specificity of a AAA+ protease.
Molecular cell 2007;25(1):161-6.
2006: Baker Tania A; Sauer Robert T
ATP-dependent proteases of bacteria: recognition logic and operating principles.
Trends in biochemical sciences 2006;31(12):647-53.
2006: McGinness Kathleen E; Baker Tania A; Sauer Robert T
Engineering controllable protein degradation.
Molecular cell 2006;22(5):701-7.
2006: Neher Saskia B; Villén Judit; Oakes Elizabeth C; Bakalarski Corey E; Sauer Robert T; Gygi Steven P; Baker Tania A
Proteomic profiling of ClpXP substrates after DNA damage reveals extensive instability within SOS regulon.
Molecular cell 2006;22(2):193-204.
2005: Martin Andreas; Baker Tania A; Sauer Robert T
Rebuilt AAA + motors reveal operating principles for ATP-fuelled machines.
Nature 2005;437(7062):1115-20.
2005: Bolon Daniel N; Grant Robert A; Baker Tania A; Sauer Robert T
Specificity versus stability in computational protein design.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(36):12724-9.
2005: Burton Briana M; Baker Tania A
Remodeling protein complexes: insights from the AAA+ unfoldase ClpX and Mu transposase.
Protein science : a publication of the Protein Society 2005;14(8):1945-54.
2005: Hersch Greg L; Burton Randall E; Bolon Daniel N; Baker Tania A; Sauer Robert T
Asymmetric interactions of ATP with the AAA+ ClpX6 unfoldase: allosteric control of a protein machine.
Cell 2005;121(7):1017-27.
2005: Levchenko Igor; Grant Robert A; Flynn Julia M; Sauer Robert T; Baker Tania A
Versatile modes of peptide recognition by the AAA+ adaptor protein SspB.
Nature structural & molecular biology 2005;12(6):520-5.
2005: Burton Randall E; Baker Tania A; Sauer Robert T
Nucleotide-dependent substrate recognition by the AAA+ HslUV protease.
Nature structural & molecular biology 2005;12(3):245-51.
2005: Kenniston Jon A; Baker Tania A; Sauer Robert T
Partitioning between unfolding and release of native domains during ClpXP degradation determines substrate selectivity and partial processing.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(5):1390-5.
2004: Bolon Daniel N; Grant Robert A; Baker Tania A; Sauer Robert T
Nucleotide-dependent substrate handoff from the SspB adaptor to the AAA+ ClpXP protease.
Molecular cell 2004;16(3):343-50.
2004: Sauer Robert T; Bolon Daniel N; Burton Briana M; Burton Randall E; Flynn Julia M; Grant Robert A; Hersch Greg L; Joshi Shilpa A; Kenniston Jon A; Levchenko Igor; Neher Saskia B; Oakes Elizabeth S C; Siddiqui Samia M; Wah David A; Baker Tania A
Sculpting the proteome with AAA(+) proteases and disassembly machines.
Cell 2004;119(1):9-18.
2004: Flynn Julia M; Levchenko Igor; Sauer Robert T; Baker Tania A
Modulating substrate choice: the SspB adaptor delivers a regulator of the extracytoplasmic-stress response to the AAA+ protease ClpXP for degradation.
Genes & development 2004;18(18):2292-301.
2004: Hersch Greg L; Baker Tania A; Sauer Robert T
SspB delivery of substrates for ClpXP proteolysis probed by the design of improved degradation tags.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(33):12136-41.
2004: Joshi Shilpa A; Hersch Greg L; Baker Tania A; Sauer Robert T
Communication between ClpX and ClpP during substrate processing and degradation.
Nature structural & molecular biology 2004;11(5):404-11.
2004: Kenniston Jon A; Burton Randall E; Siddiqui Samia M; Baker Tania A; Sauer Robert T
Effects of local protein stability and the geometric position of the substrate degradation tag on the efficiency of ClpXP denaturation and degradation.
Journal of structural biology 2004;146(1-2):130-40.
2004: Siddiqui Samia M; Sauer Robert T; Baker Tania A
Role of the processing pore of the ClpX AAA+ ATPase in the recognition and engagement of specific protein substrates.
Genes & development 2004;18(4):369-74.
2004: Bolon Daniel N; Wah David A; Hersch Greg L; Baker Tania A; Sauer Robert T
Bivalent tethering of SspB to ClpXP is required for efficient substrate delivery: a protein-design study.
Molecular cell 2004;13(3):443-9.
2004: Williams Tanya L; Baker Tania A
Reorganization of the Mu transpososome active sites during a cooperative transition between DNA cleavage and joining.
The Journal of biological chemistry 2004;279(7):5135-45.
2003: Spector Shari; Flynn Julia M; Tidor Bruce; Baker Tania A; Sauer Robert T
Expression of N-formylated proteins in Escherichia coli.
Protein expression and purification 2003;32(2):317-22.
2003: Goldhaber-Gordon Ilana; Early Michael H; Baker Tania A
MuA transposase separates DNA sequence recognition from catalysis.
Biochemistry 2003;42(49):14633-42.
2003: Neher Saskia B; Sauer Robert T; Baker Tania A
Distinct peptide signals in the UmuD and UmuD' subunits of UmuD/D' mediate tethering and substrate processing by the ClpXP protease.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(23):13219-24.
2003: Levchenko Igor; Grant Robert A; Wah David A; Sauer Robert T; Baker Tania A
Structure of a delivery protein for an AAA+ protease in complex with a peptide degradation tag.
Molecular cell 2003;12(2):365-72.
2003: Wah David A; Levchenko Igor; Rieckhof Gabrielle E; Bolon Daniel N; Baker Tania A; Sauer Robert T
Flexible linkers leash the substrate binding domain of SspB to a peptide module that stabilizes delivery complexes with the AAA+ ClpXP protease.
Molecular cell 2003;12(2):355-63.
2003: Kenniston Jon A; Baker Tania A; Fernandez Julio M; Sauer Robert T
Linkage between ATP consumption and mechanical unfolding during the protein processing reactions of an AAA+ degradation machine.
Cell 2003;114(4):511-20.
2003: Goldhaber-Gordon Ilana; Early Michael H; Baker Tania A
The terminal nucleotide of the Mu genome controls catalysis of DNA strand transfer.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(13):7509-14.
2003: Burton Briana M; Baker Tania A
Mu transpososome architecture ensures that unfolding by ClpX or proteolysis by ClpXP remodels but does not destroy the complex.
Chemistry & biology 2003;10(5):463-72.
2003: Neher Saskia B; Flynn Julia M; Sauer Robert T; Baker Tania A
Latent ClpX-recognition signals ensure LexA destruction after DNA damage.
Genes & development 2003;17(9):1084-9.
2003: Burton Randall E; Baker Tania A; Sauer Robert T
Energy-dependent degradation: Linkage between ClpX-catalyzed nucleotide hydrolysis and protein-substrate processing.
Protein science : a publication of the Protein Society 2003;12(5):893-902.
2003: Joshi Shilpa A; Baker Tania A; Sauer Robert T
C-terminal domain mutations in ClpX uncouple substrate binding from an engagement step required for unfolding.
Molecular microbiology 2003;48(1):67-76.
2003: Flynn Julia M; Neher Saskia B; Kim Yong In; Sauer Robert T; Baker Tania A
Proteomic discovery of cellular substrates of the ClpXP protease reveals five classes of ClpX-recognition signals.
Molecular cell 2003;11(3):671-83.
2003: Sokolsky Tanya D; Baker Tania A
DNA gyrase requirements distinguish the alternate pathways of Mu transposition.
Molecular microbiology 2003;47(2):397-409.
2002: Wah David A; Levchenko Igor; Baker Tania A; Sauer Robert T
Characterization of a specificity factor for an AAA+ ATPase: assembly of SspB dimers with ssrA-tagged proteins and the ClpX hexamer.
Chemistry & biology 2002;9(11):1237-45.
2002: Goldhaber-Gordon Ilana; Early Michael H; Gray Matthew K; Baker Tania A
Sequence and positional requirements for DNA sites in a mu transpososome.
The Journal of biological chemistry 2002;277(10):7703-12.
2002: Goldhaber-Gordon Ilana; Williams Tanya L; Baker Tania A
DNA recognition sites activate MuA transposase to perform transposition of non-Mu DNA.
The Journal of biological chemistry 2002;277(10):7694-702.
2001: Flynn J M; Levchenko I; Seidel M; Wickner S H; Sauer R T; Baker T A
Overlapping recognition determinants within the ssrA degradation tag allow modulation of proteolysis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(19):10584-9.
2001: Burton B M; Williams T L; Baker T A
ClpX-mediated remodeling of mu transpososomes: selective unfolding of subunits destabilizes the entire complex.
Molecular cell 2001;8(2):449-54.
2001: Burton R E; Siddiqui S M; Kim Y I; Baker T A; Sauer R T
Effects of protein stability and structure on substrate processing by the ClpXP unfolding and degradation machine.
The EMBO journal 2001;20(12):3092-100.
2001: Roldan L A; Baker T A
Differential role of the Mu B protein in phage Mu integration vs. replication: mechanistic insights into two transposition pathways.
Molecular microbiology 2001;40(1):141-55.
2001: Lo J H; Baker T A; Sauer R T
Characterization of the N-terminal repeat domain of Escherichia coli ClpA-A class I Clp/HSP100 ATPase.
Protein science : a publication of the Protein Society 2001;10(3):551-9.
2001: Kim Y I; Levchenko I; Fraczkowska K; Woodruff R V; Sauer R T; Baker T A
Molecular determinants of complex formation between Clp/Hsp100 ATPases and the ClpP peptidase.
Nature structural biology 2001;8(3):230-3.
2000: Levchenko I; Seidel M; Sauer R T; Baker T A
A specificity-enhancing factor for the ClpXP degradation machine.
Science (New York, N.Y.) 2000;289(5488):2354-6.
2000: Williams T L; Baker T A
Molecular biology. Transposase team puts a headlock on DNA.
Science (New York, N.Y.) 2000;289(5476):73-4.
2000: Kim Y I; Burton R E; Burton B M; Sauer R T; Baker T A
Dynamics of substrate denaturation and translocation by the ClpXP degradation machine.
Molecular cell 2000;5(4):639-48.
1999: Williams T L; Jackson E L; Carritte A; Baker T A
Organization and dynamics of the Mu transpososome: recombination by communication between two active sites.
Genes & development 1999;13(20):2725-37.
1999: Smith C K; Baker T A; Sauer R T
Lon and Clp family proteases and chaperones share homologous substrate-recognition domains.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(12):6678-82.
1998: Krementsova E; Giffin M J; Pincus D; Baker T A
Mutational analysis of the Mu transposase. Contributions of two distinct regions of domain II to recombination.
The Journal of biological chemistry 1998;273(47):31358-65.
1998: Yamauchi M; Baker T A
An ATP-ADP switch in MuB controls progression of the Mu transposition pathway.
The EMBO journal 1998;17(18):5509-18.
1998: Baker T A; Bell S P
Polymerases and the replisome: machines within machines.
Cell 1998;92(3):295-305.
1997: Levchenko I; Smith C K; Walsh N P; Sauer R T; Baker T A
PDZ-like domains mediate binding specificity in the Clp/Hsp100 family of chaperones and protease regulatory subunits.
Cell 1997;91(7):939-47.
1997: Levchenko I; Yamauchi M; Baker T A
ClpX and MuB interact with overlapping regions of Mu transposase: implications for control of the transposition pathway.
Genes & development 1997;11(12):1561-72.
1996: Aldaz H; Schuster E; Baker T A
The interwoven architecture of the Mu transposase couples DNA synapsis to catalysis.
Cell 1996;85(2):257-69.
1995: Levchenko I; Luo L; Baker T A
Disassembly of the Mu transposase tetramer by the ClpX chaperone.
Genes & development 1995;9(19):2399-408.
1995: Baker T A
Replication arrest.
Cell 1995;80(4):521-4.
1994: Baker T A; Kremenstova E; Luo L
Complete transposition requires four active monomers in the mu transposase tetramer.
Genes & development 1994;8(20):2416-28.
1994: Baker T A
Replication initiation. A new controller in Escherichia coli.
Current biology : CB 1994;4(10):945-6.
1994: Baker T A; Luo L
Identification of residues in the Mu transposase essential for catalysis.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(14):6654-8.
1993: Baker T A
Protein-DNA assemblies controlling lytic development of bacteriophage Mu.
Current opinion in genetics & development 1993;3(5):708-12.
1993: Baker T A
DNA topology: untangling the steps in chromosome segregation.
Current biology : CB 1993;3(2):94-6.

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