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Klaus Klumpp

Research Profile

Living Beings

Hepacivirus

Chemicals & Drugs

Physiology

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Publications

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Nguyet Minh Nguyen; Quyen Than Ha Nguyen; Truong Thanh Nguyen; Rosemary Petric; Mai Phuong Pham; Lam Khanh Phung; Chau Nguyen Bich Tran; Hien Tinh Tran; Andreas Wilm; Marcel Wolbers; Pauline P K Aw; Kien Thi Hue Duong; Jeremy Farrar; Janet Hammond; Martin L Hibberd; Long Truong Hoang; Huy le Anh Huynh; Hassan Javanbakht; Klaus Klumpp; Laura Merson; Niranjan Nagarajan; Chinh Tran Nguyen; Chau Van Vinh Nguyen; Dung Thi Nguyen; Cameron P Simmons
A randomized, double-blind placebo controlled trial of balapiravir, a polymerase inhibitor, in adult dengue patients.
Zhinan Jin; Kenneth A Johnson; Vincent Leveque; Han Ma; Klaus Klumpp
NTP-mediated nucleotide excision activity of hepatitis C virus RNA-dependent RNA polymerase.
Simon P Fletcher; Lore Gruenbaum; Klaus Klumpp; Han Ma; Hans Bitter; Donavan T Cheng; Daniel J Chin; Paul J Cote; Palanikumar Ravindran; Stephan Menne
Identification of an intrahepatic transcriptional signature associated with self-limiting infection in the woodchuck model of hepatitis B.

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All Publications

2013: Nguyet Minh Nguyen; Quyen Than Ha Nguyen; Truong Thanh Nguyen; Rosemary Petric; Mai Phuong Pham; Lam Khanh Phung; Chau Nguyen Bich Tran; Hien Tinh Tran; Andreas Wilm; Marcel Wolbers; Pauline P K Aw; Kien Thi Hue Duong; Jeremy Farrar; Janet Hammond; Martin L Hibberd; Long Truong Hoang; Huy le Anh Huynh; Hassan Javanbakht; Klaus Klumpp; Laura Merson; Niranjan Nagarajan; Chinh Tran Nguyen; Chau Van Vinh Nguyen; Dung Thi Nguyen; Cameron P Simmons
A randomized, double-blind placebo controlled trial of balapiravir, a polymerase inhibitor, in adult dengue patients.
The Journal of infectious diseases 2013;207(9):1442-50.
2013: Zhinan Jin; Kenneth A Johnson; Vincent Leveque; Han Ma; Klaus Klumpp
NTP-mediated nucleotide excision activity of hepatitis C virus RNA-dependent RNA polymerase.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(5):E348-57.
2013: Simon P Fletcher; Lore Gruenbaum; Klaus Klumpp; Han Ma; Hans Bitter; Donavan T Cheng; Daniel J Chin; Paul J Cote; Palanikumar Ravindran; Stephan Menne
Identification of an intrahepatic transcriptional signature associated with self-limiting infection in the woodchuck model of hepatitis B.
Hepatology (Baltimore, Md.) 2013;57(1):13-22.
2012: Sophie Le Pogam; N S Shulman; P Smith; J M Yan; Samir Ali; M Chhabra; Daniel J Chin; M Ilnicka; Hyunsoon Kang; Klaus Klumpp; A Kosaka; Isabel Nájera
Characterization of hepatitis C virus (HCV) quasispecies dynamics upon short-term dual therapy with the HCV NS5B nucleoside polymerase inhibitor mericitabine and the NS3/4 protease inhibitor danoprevir.
Antimicrobial agents and chemotherapy 2012;56(11):5494-502.
2012: Simon P Fletcher; A Leonardo Iniguez; Yongmei Ji; Klaus Klumpp; Uri Lopatin; Han Ma; Hans Bitter; Donavan T Cheng; Daniel J Chin; Palanikumar Ravindran; David C Swinney; Bruce Taillon; Stephan Menne
Transcriptomic analysis of the woodchuck model of chronic hepatitis B.
Hepatology (Baltimore, Md.) 2012;56(3):820-30.
2012: Magnus Nilsson; Michael Pelcman; Pedro Pinho; Pierre Raboisson; Sa Rosenquist; Christina Rydegård; Bertil Samuelsson; Kenneth Simmen; David B Smith; Christian Sund; Ylva Terelius; Koen Vandyck; Lotta Vrang; Horst Wähling; Kristina Wikström; Anna Winqvist; Xiao-Xiong Zhou; Tatiana Agback; Anna-Karin Belfrage; Kurt Benckestock; Mirva Boothee; Herman de Kock; Tim H M Jonckers; Genadiy Kalayanov; Klaus Klumpp; Sophie Lachau-Durand; Tse-I Lin; Anneli Lindqvist; Joseph A Martin; Nils Gunnar Johansson
Discovery of 4'-azido-2'-deoxy-2'-C-methyl cytidine and prodrugs thereof: a potent inhibitor of Hepatitis C virus replication.
Bioorganic & medicinal chemistry letters 2012;22(9):3265-8.
2012: Zhinan Jin; Kenneth A Johnson; Vincent Leveque; Han Ma; Klaus Klumpp
Assembly, purification, and pre-steady-state kinetic analysis of active RNA-dependent RNA polymerase elongation complex.
The Journal of biological chemistry 2012;287(13):10674-83.
2010: Derek R Latour; andreas jekle; Hassan Javanbakht; Robert Henningsen; Peter Gee; Ina Lee; Patricia Tran; Suping Ren; Alan K Kutach; Seth F Harris; Sandra M Wang; Stephen J Lok; David Shaw; Jim Li; Gabrielle Heilek; Klaus Klumpp; David C Swinney; Jerome Deval
Biochemical characterization of the inhibition of the dengue virus RNA polymerase by beta-d-2'-ethynyl-7-deaza-adenosine triphosphate.
Antiviral research 2010;87(2):213-22.
2010: Denis J Kertesz; Christine Brotherton-Pleiss; Minmin Yang; Zhanguo Wang; Xianfeng Lin; Zongxing Qiu; Donald R Hirschfeld; Shelley Gleason; Tara Mirzadegan; Pete Dunten; Seth F Harris; Armando G Villaseñor; Julie Qi Hang; Gabrielle M Heilek; Klaus Klumpp
Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-benzyl derivatives with broad potency against resistant mutant viruses.
Bioorganic & medicinal chemistry letters 2010;20(14):4215-8.
2009: Christopher McGuigan; Mary Rose Kelleher; Plinio Perrone; Sinead Mulready; Giovanna M Luoni; Felice Daverio; Sonal Rajyaguru; Sophie Le Pogam; Isabel Najera; Joseph A Martin; Klaus Klumpp; David B Smith
The application of phosphoramidate ProTide technology to the potent anti-HCV compound 4'-azidocytidine (R1479).
Bioorganic & medicinal chemistry letters 2009;19(15):4250-4.
2009: Christopher McGuigan; Felice Daverio; Isabel Nájera; Joseph A Martin; Klaus Klumpp; David B Smith
The application of the phosphoramidate ProTide approach confers micromolar potency against hepatitis C virus on inactive agent 4'-azidoinosine: kinase bypass on a dual base/sugar modified nucleoside.
Bioorganic & medicinal chemistry letters 2009;19(11):3122-4.
2009: David B Smith; Genadiy Kalayanov; Christian Sund; Anna Winqvist; Tatiana Maltseva; Vincent J-P Leveque; Sonal Rajyaguru; Sophie Le Pogam; Isabel Najera; Kurt Benkestock; Xiao-Xiong Zhou; Ann C Kaiser; Hans Maag; Nick Cammack; Joseph A Martin; Steven Swallow; Nils Gunnar Johansson; Klaus Klumpp; Mark Smith
The design, synthesis, and antiviral activity of monofluoro and difluoro analogues of 4'-azidocytidine against hepatitis C virus replication: the discovery of 4'-azido-2'-deoxy-2'-fluorocytidine and 4'-azido-2'-dideoxy-2',2'-difluorocytidine.
Journal of medicinal chemistry 2009;52(9):2971-8.
2009: David B Smith; Genadiy Kalayanov; Christian Sund; Anna Winqvist; Pedro Pinho; Tatiana Maltseva; Veronique Morisson; Vincent Leveque; Sonal Rajyaguru; Sophie Le Pogam; Isabel Najera; Kurt Benkestock; Xiao-Xiong Zhou; Hans Maag; Nick Cammack; Joseph A Martin; Steven Swallow; Nils Gunnar Johansson; Klaus Klumpp; Mark Smith
The design, synthesis, and antiviral activity of 4'-azidocytidine analogues against hepatitis C virus replication: the discovery of 4'-azidoarabinocytidine.
Journal of medicinal chemistry 2009;52(1):219-23.
2008: Samir Ali; Vincent Leveque; Sophie Le Pogam; Han Ma; Friederike Philipp; Nicole Inocencio; Mark Smith; Andre Alker; Hyunsoon Kang; Isabel Najera; Klaus Klumpp; Julian Symons; Nick Cammack; Wen-Rong Jiang
Selected replicon variants with low-level in vitro resistance to the hepatitis C virus NS5B polymerase inhibitor PSI-6130 lack cross-resistance with R1479.
Antimicrobial agents and chemotherapy 2008;52(12):4356-69.
2008: Zachary K Sweeney; James P Dunn; Yu Li; Gabrielle Heilek; Pete Dunten; Todd R Elworthy; Xiaochun Han; Seth F Harris; Donald R Hirschfeld; J Heather Hogg; Walter Huber; Ann C Kaiser; Denis J Kertesz; Woongki Kim; Tara Mirzadegan; Michael G Roepel; Y David Saito; Tania M P C Silva; Steven Swallow; Jahari L Tracy; Armando Villasenor; Harit Vora; Amy S Zhou; Klaus Klumpp
Discovery and optimization of pyridazinone non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Bioorganic & medicinal chemistry letters 2008;18(15):4352-4.
2008: Zachary K Sweeney; Sahaja Acharya; Andrew Briggs; James P Dunn; Todd R Elworthy; Jennifer Fretland; Anthony M Giannetti; Gabrielle Heilek; Yu Li; Ann C Kaiser; Michael Martin; Y David Saito; Mark Smith; Judy M Suh; Steven Swallow; Jeffrey Wu; Julie Qi Hang; Amy S Zhou; Klaus Klumpp
Discovery of triazolinone non-nucleoside inhibitors of HIV reverse transcriptase.
Bioorganic & medicinal chemistry letters 2008;18(15):4348-51.
2008: Peter Gee; Pong Kian Chua; Jirair Gevorkyan; Klaus Klumpp; Isabel Najera; David C Swinney; Jerome Deval
Essential role of the N-terminal domain in the regulation of RIG-I ATPase activity.
The Journal of biological chemistry 2008;283(14):9488-96.
2008: Klaus Klumpp; Genadiy Kalayanov; Han Ma; Sophie Le Pogam; Vincent Leveque; Wen-Rong Jiang; Nicole Inocencio; Anniek De Witte; Sonal Rajyaguru; Ezra Tai; Sushmita Chanda; Michael R Irwin; Christian Sund; Anna Winqist; Tatiana Maltseva; Staffan Eriksson; Elena Usova; Mark Smith; Andre Alker; Isabel Najera; Nick Cammack; Joseph A Martin; Nils Gunnar Johansson; David B Smith
2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groups.
The Journal of biological chemistry 2008;283(4):2167-75.
2007: Plinio Perrone; Felice Daverio; Rocco Valente; Sonal Rajyaguru; Joseph A Martin; Vincent Lévêque; Sophie Le Pogam; Isabel Najera; Klaus Klumpp; David B Smith; Christopher McGuigan
First example of phosphoramidate approach applied to a 4'-substituted purine nucleoside (4'-azidoadenosine): conversion of an inactive nucleoside to a submicromolar compound versus hepatitis C virus.
Journal of medicinal chemistry 2007;50(22):5463-70.
2007: Han Ma; Wen-Rong Jiang; Nicole Robledo; Vincent Leveque; Samir Ali; Teresa Lara-Jaime; Mohammad Masjedizadeh; David B Smith; Nick Cammack; Klaus Klumpp; Julian Symons
Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species.
The Journal of biological chemistry 2007;282(41):29812-20.
2007: David B Smith; Joseph A Martin; Klaus Klumpp; Stewart J Baker; Peter A Blomgren; Rene Devos; Caroline Granycome; Julie Qi Hang; Christopher J Hobbs; Wen-Rong Jiang; Carl Laxton; Sophie Le Pogam; Vincent Leveque; Han Ma; Graham Maile; John H Merrett; Arkadius Pichota; Keshab Sarma; Mark Smith; Steven Swallow; Julian Symons; David Vesey; Isabel Najera; Nick Cammack
Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479.
Bioorganic & medicinal chemistry letters 2007;17(9):2570-6.
2007: Plinio Perrone; Giovanna M Luoni; Mary Rose Kelleher; Felice Daverio; Annette Angell; Sinead Mulready; Costantino Congiatu; Sonal Rajyaguru; Joseph A Martin; Vincent Levêque; Sophie Le Pogam; Isabel Najera; Klaus Klumpp; David B Smith; Christopher McGuigan
Application of the phosphoramidate ProTide approach to 4'-azidouridine confers sub-micromolar potency versus hepatitis C virus on an inactive nucleoside.
Journal of medicinal chemistry 2007;50(8):1840-9.
2007: Julie Qi Hang; Yu Li; Yanli Yang; Nick Cammack; Tara Mirzadegan; Klaus Klumpp
Substrate-dependent inhibition or stimulation of HIV RNase H activity by non-nucleoside reverse transcriptase inhibitors (NNRTIs).
Biochemical and biophysical research communications 2007;352(2):341-50.
2006: Sophie Le Pogam; Wen-Rong Jiang; Vincent Leveque; Sonal Rajyaguru; Han Ma; Hyunsoon Kang; Sharon Jiang; Margaret Singer; Samir Ali; Klaus Klumpp; Dave Smith; Julian Symons; Nick Cammack; Isabel Nájera
In vitro selected Con1 subgenomic replicons resistant to 2'-C-methyl-cytidine or to R1479 show lack of cross resistance.
Virology 2006;351(2):349-59.
2006: Sophie Le Pogam; Hyunsoon Kang; Seth F Harris; Vincent Leveque; Anthony M Giannetti; Samir Ali; Wen-Rong Jiang; Sonal Rajyaguru; Gisele Tavares; Connie Oshiro; Than Hendricks; Klaus Klumpp; Julian Symons; Michelle F Browner; Nick Cammack; Isabel Nájera
Selection and characterization of replicon variants dually resistant to thumb- and palm-binding nonnucleoside polymerase inhibitors of the hepatitis C virus.
Journal of virology 2006;80(12):6146-54.
2006: Klaus Klumpp; Vincent Lévêque; Sophie Le Pogam; Han Ma; Wen-Rong Jiang; Hyunsoon Kang; Caroline Granycome; Margaret Singer; Carl Laxton; Julie Qi Hang; Keshab Sarma; David B Smith; Dieter Heindl; Chris J Hobbs; John H Merrett; Julian Symons; Nick Cammack; Joseph A Martin; Rene Devos; Isabel Nájera
The novel nucleoside analog R1479 (4'-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture.
The Journal of biological chemistry 2006;281(7):3793-9.
2006: Klaus Klumpp; Tara Mirzadegan
Recent progress in the design of small molecule inhibitors of HIV RNase H.
Current pharmaceutical design 2006;12(15):1909-22.
2006: Klaus Klumpp; Bradford J Graves
Optimization of small molecule drugs binding to highly polar target sites: lessons from the discovery and development of neuraminidase inhibitors.
Current topics in medicinal chemistry 2006;6(5):423-34.
2005: Han Ma; Vincent Leveque; Anniek De Witte; Weixing Li; Than Hendricks; Saundra M Clausen; Nick Cammack; Klaus Klumpp
Inhibition of native hepatitis C virus replicase by nucleotide and non-nucleoside inhibitors.
Virology 2005;332(1):8-15.
2004: Julie Qi Hang; Surendran Rajendran; Yanli Yang; Yu Li; Philippe Wong Kai In; Hilary Overton; Kevin E B Parkes; Nick Cammack; Joseph A Martin; Klaus Klumpp
Activity of the isolated HIV RNase H domain and specific inhibition by N-hydroxyimides.
Biochemical and biophysical research communications 2004;317(2):321-9.
2003: Klaus Klumpp; Julie Qi Hang; Surendran Rajendran; Yanli Yang; Andre Derosier; Philippe Wong Kai In; Hilary Overton; Kevin E B Parkes; Nick Cammack; Joseph A Martin
Two-metal ion mechanism of RNA cleavage by HIV RNase H and mechanism-based design of selective HIV RNase H inhibitors.
Nucleic acids research 2003;31(23):6852-9.
2003: Lisa Hooker; Rachel Sully; Balraj Handa; Naomi Ono; Hiroshi Koyano; Klaus Klumpp
Quantitative analysis of influenza virus RNP interaction with RNA cap structures and comparison to human cap binding protein eIF4E.
Biochemistry 2003;42(20):6234-40.
2003: Kevin E B Parkes; Philipp Ermert; Jürg Fässler; Jane Ives; Joseph A Martin; John H Merrett; Daniel Obrecht; Glyn Williams; Klaus Klumpp
Use of a pharmacophore model to discover a new class of influenza endonuclease inhibitors.
Journal of medicinal chemistry 2003;46(7):1153-64.
2001: Lisa Hooker; R Strong; R Adams; Balraj Handa; John H Merrett; Joseph A Martin; Klaus Klumpp
A sensitive, single-tube assay to measure the enzymatic activities of influenza RNA polymerase and other poly(A) polymerases: application to kinetic and inhibitor analysis.
Nucleic acids research 2001;29(13):2691-8.
2001: Klaus Klumpp; Lisa Hooker; Balraj Handa
Influenza virus endoribonuclease.
Methods in enzymology 2001;342():451-66.
2000: Klaus Klumpp; L Doan; NA Roberts; Balraj Handa
RNA and DNA hydrolysis are catalyzed by the influenza virus endonuclease.
The Journal of biological chemistry 2000;275(9):6181-8.
1999: L Doan; Balraj Handa; NA Roberts; Klaus Klumpp
Metal ion catalysis of RNA cleavage by the influenza virus endonuclease.
Biochemistry 1999;38(17):5612-9.