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William Klunk

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
Grimmer Timo; Henriksen Gjermund; Wester Hans-Jürgen; Förstl Hans; Klunk William E; Mathis Chester A; Kurz Alexander; Drzezga Alexander
Clinical severity of Alzheimer's disease is associated with PIB uptake in PET.
Wolk David A; Klunk William
Update on amyloid imaging: from healthy aging to Alzheimer's disease.
Venneti Sriram; Lopresti Brian J; Wang Guoji; Hamilton Ronald L; Mathis Chester A; Klunk William E; Apte Udayan M; Wiley Clayton A
PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET.

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All Publications

2009: Grimmer Timo; Henriksen Gjermund; Wester Hans-Jürgen; Förstl Hans; Klunk William E; Mathis Chester A; Kurz Alexander; Drzezga Alexander
Clinical severity of Alzheimer's disease is associated with PIB uptake in PET.
Neurobiology of aging 2009;30(12):1902-9.
2009: Wolk David A; Klunk William
Update on amyloid imaging: from healthy aging to Alzheimer's disease.
Current neurology and neuroscience reports 2009;9(5):345-52.
2009: Venneti Sriram; Lopresti Brian J; Wang Guoji; Hamilton Ronald L; Mathis Chester A; Klunk William E; Apte Udayan M; Wiley Clayton A
PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET.
Neurobiology of aging 2009;30(8):1217-26.
2009: Grimmer Timo; Riemenschneider Matthias; Förstl Hans; Henriksen Gjermund; Klunk William E; Mathis Chester A; Shiga Tohru; Wester Hans-Jürgen; Kurz Alexander; Drzezga Alexander
Beta amyloid in Alzheimer's disease: increased deposition in brain is reflected in reduced concentration in cerebrospinal fluid.
Biological psychiatry 2009;65(11):927-34.
2009: Lopez O L; Becker J T; Wahed A S; Saxton J; Sweet R A; Wolk D A; Klunk W; Dekosky S T
Long-term effects of the concomitant use of memantine with cholinesterase inhibition in Alzheimer disease.
Journal of neurology, neurosurgery, and psychiatry 2009;80(6):600-7.
2009: Wolk David A; Price Julie C; Saxton Judy A; Snitz Beth E; James Jeffrey A; Lopez Oscar L; Aizenstein Howard J; Cohen Ann D; Weissfeld Lisa A; Mathis Chester A; Klunk William E; De-Kosky Steven T;
Amyloid imaging in mild cognitive impairment subtypes.
Annals of neurology 2009;65(5):557-68.
2009: Reiman Eric M; Chen Kewei; Liu Xiaofen; Bandy Daniel; Yu Meixiang; Lee Wendy; Ayutyanont Napatkamon; Keppler Jennifer; Reeder Stephanie A; Langbaum Jessica B S; Alexander Gene E; Klunk William E; Mathis Chester A; Price Julie C; Aizenstein Howard J; DeKosky Steven T; Caselli Richard J
Fibrillar amyloid-beta burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(16):6820-5.
2009: Lin Kuo-Shyan; Debnath Manik L; Mathis Chester A; Klunk William E
Synthesis and beta-amyloid binding properties of rhenium 2-phenylbenzothiazoles.
Bioorganic & medicinal chemistry letters 2009;19(8):2258-62.
2009: Carrillo Maria C; Blackwell Andrew; Hampel Harald; Lindborg Johan; Sperling Reisa; Schenk Dale; Sevigny Jeffrey J; Ferris Steven; Bennett David A; Craft Suzanne; Hsu Timothy; Klunk William
Early risk assessment for Alzheimer's disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2009;5(2):182-96.
2009: McNamee Rebecca L; Yee Seong-Hwan; Price Julie C; Klunk William E; Rosario Bedda; Weissfeld Lisa; Ziolko Scott; Berginc Michael; Lopresti Brian; Dekosky Steven; Mathis Chester A
Consideration of optimal time window for Pittsburgh compound B PET summed uptake measurements.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2009;50(3):348-55.
2009: Wiley Clayton A; Lopresti Brian J; Venneti Sriram; Price Julie; Klunk William E; DeKosky Steven T; Mathis Chester A
Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease.
Archives of neurology 2009;66(1):60-7.
2008: Klunk William E; Mathis Chester A
The future of amyloid-beta imaging: a tale of radionuclides and tracer proliferation.
Current opinion in neurology 2008;21(6):683-7.
2008: Aizenstein Howard Jay; Nebes Robert D; Saxton Judith A; Price Julie C; Mathis Chester A; Tsopelas Nicholas D; Ziolko Scott K; James Jeffrey A; Snitz Beth E; Houck Patricia R; Bi Wenzhu; Cohen Ann D; Lopresti Brian J; DeKosky Steven T; Halligan Edythe M; Klunk William E
Frequent amyloid deposition without significant cognitive impairment among the elderly.
Archives of neurology 2008;65(11):1509-17.
2008: Klunk William E
Biopsy support for the validity of Pittsburgh compound B positron emission tomography with a twist.
Archives of neurology 2008;65(10):1281-3.
2008: Gomperts S N; Rentz D M; Moran E; Becker J A; Locascio J J; Klunk W E; Mathis C A; Elmaleh D R; Shoup T; Fischman A J; Hyman B T; Growdon J H; Johnson K A
Imaging amyloid deposition in Lewy body diseases.
Neurology 2008;71(12):903-10.
2008: Sojkova Jitka; Beason-Held Lori; Zhou Yun; An Yang; Kraut Michael A; Ye Weigo; Ferrucci Luigi; Mathis Chester A; Klunk William E; Wong Dean F; Resnick Susan M
Longitudinal cerebral blood flow and amyloid deposition: an emerging pattern?
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008;49(9):1465-71.
2008: Klunk William E; Mathis Chester A
Whatever happened to Pittsburgh Compound-A?
Alzheimer disease and associated disorders 2008;22(3):198-203.
2008: Bateman Randall J; Klunk William E
Measuring target effect of proposed disease-modifying therapies in Alzheimer's disease.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2008;5(3):381-90.
2008: Raji Cyrus A; Becker James T; Tsopelas Nicholas D; Price Julie C; Mathis Chester A; Saxton Judith A; Lopresti Brian J; Hoge Jessica A; Ziolko Scott K; DeKosky Steven T; Klunk William E
Characterizing regional correlation, laterality and symmetry of amyloid deposition in mild cognitive impairment and Alzheimer's disease with Pittsburgh Compound B.
Journal of neuroscience methods 2008;172(2):277-82.
2008: Butters Meryl A; Klunk William E; Mathis Chester A; Price Julie C; Ziolko Scott K; Hoge Jessica A; Tsopelas Nicholas D; Lopresti Brian J; Reynolds Charles F; DeKosky Steven T; Meltzer Carolyn C
Imaging Alzheimer pathology in late-life depression with PET and Pittsburgh Compound-B.
Alzheimer disease and associated disorders 2008;22(3):261-8.
2008: Ikonomovic Milos D; Klunk William E; Abrahamson Eric E; Mathis Chester A; Price Julie C; Tsopelas Nicholas D; Lopresti Brian J; Ziolko Scott; Bi Wenzhu; Paljug William R; Debnath Manik L; Hope Caroline E; Isanski Barbara A; Hamilton Ronald L; DeKosky Steven T
Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease.
Brain : a journal of neurology 2008;131(Pt 6):1630-45.
2008: Bolmont Tristan; Haiss Florent; Eicke Daniel; Radde Rebecca; Mathis Chester A; Klunk William E; Kohsaka Shinichi; Jucker Mathias; Calhoun Michael E
Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(16):4283-92.
2008: Jack Clifford R; Lowe Val J; Senjem Matthew L; Weigand Stephen D; Kemp Bradley J; Shiung Maria M; Knopman David S; Boeve Bradley F; Klunk William E; Mathis Chester A; Petersen Ronald C
11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment.
Brain : a journal of neurology 2008;131(Pt 3):665-80.
2008: Drzezga Alexander; Grimmer Timo; Henriksen Gjermund; Stangier Isabelle; Perneczky Robert; Diehl-Schmid Janine; Mathis Chester A; Klunk William E; Price Julie; DeKosky Steve; Wester Hans-Jürgen; Schwaiger Markus; Kurz Alexander
Imaging of amyloid plaques and cerebral glucose metabolism in semantic dementia and Alzheimer's disease.
NeuroImage 2008;39(2):619-33.
2007: Pike Kerryn E; Savage Greg; Villemagne Victor L; Ng Steven; Moss Simon A; Maruff Paul; Mathis Chester A; Klunk William E; Masters Colin L; Rowe Christopher C
Beta-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease.
Brain : a journal of neurology 2007;130(Pt 11):2837-44.
2007: Mathis Chester A; Lopresti Brian J; Klunk William E
Impact of amyloid imaging on drug development in Alzheimer's disease.
Nuclear medicine and biology 2007;34(7):809-22.
2007: Johnson Keith A; Gregas Matt; Becker John A; Kinnecom Catherine; Salat David H; Moran Erin K; Smith Erin E; Rosand Jonathan; Rentz Dorene M; Klunk William E; Mathis Chester A; Price Julie C; Dekosky Steven T; Fischman Alan J; Greenberg Steven M
Imaging of amyloid burden and distribution in cerebral amyloid angiopathy.
Annals of neurology 2007;62(3):229-34.
2007: Klunk William E; Price Julie C; Mathis Chester A; Tsopelas Nicholas D; Lopresti Brian J; Ziolko Scott K; Bi Wenzhu; Hoge Jessica A; Cohen Ann D; Ikonomovic Milos D; Saxton Judith A; Snitz Beth E; Pollen Daniel A; Moonis Majaz; Lippa Carol F; Swearer Joan M; Johnson Keith A; Rentz Dorene M; Fischman Alan J; Aizenstein Howard J; DeKosky Steven T
Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(23):6174-84.
2007: Zhou Yun; Resnick Susan M; Ye Weiguo; Fan Hong; Holt Daniel P; Klunk William E; Mathis Chester A; Dannals Robert; Wong Dean F
Using a reference tissue model with spatial constraint to quantify [11C]Pittsburgh compound B PET for early diagnosis of Alzheimer's disease.
NeuroImage 2007;36(2):298-312.
2007: Rowe C C; Ng S; Ackermann U; Gong S J; Pike K; Savage G; Cowie T F; Dickinson K L; Maruff P; Darby D; Smith C; Woodward M; Merory J; Tochon-Danguy H; O'Keefe G; Klunk W E; Mathis C A; Price J C; Masters C L; Villemagne V L
Imaging beta-amyloid burden in aging and dementia.
Neurology 2007;68(20):1718-25.
2007: Rabinovici G D; Furst A J; O'Neil J P; Racine C A; Mormino E C; Baker S L; Chetty S; Patel P; Pagliaro T A; Klunk W E; Mathis C A; Rosen H J; Miller B L; Jagust W J
11C-PIB PET imaging in Alzheimer disease and frontotemporal lobar degeneration.
Neurology 2007;68(15):1205-12.
2007: Bacskai Brian J; Frosch Matthew P; Freeman Stefanie H; Raymond Scott B; Augustinack Jean C; Johnson Keith A; Irizarry Michael C; Klunk William E; Mathis Chester A; Dekosky Steven T; Greenberg Steven M; Hyman Bradley T; Growdon John H
Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report.
Archives of neurology 2007;64(3):431-4.
2006: Klunk William E; Mathis Chester A; Price Julie C; Lopresti Brian J; DeKosky Steven T
Two-year follow-up of amyloid deposition in patients with Alzheimer's disease.
Brain : a journal of neurology 2006;129(Pt 11):2805-7.
2006: Ziolko Scott K; Weissfeld Lisa A; Klunk William E; Mathis Chester A; Hoge Jessica A; Lopresti Brian J; DeKosky Steven T; Price Julie C
Evaluation of voxel-based methods for the statistical analysis of PIB PET amyloid imaging studies in Alzheimer's disease.
NeuroImage 2006;33(1):94-102.
2006: Mintun M A; Larossa G N; Sheline Y I; Dence C S; Lee S Y; Mach R H; Klunk W E; Mathis C A; DeKosky S T; Morris J C
[11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease.
Neurology 2006;67(3):446-52.
2006: Stankoff Bruno; Wang Yanming; Bottlaender Michel; Aigrot Marie-Stephane; Dolle Frederic; Wu Chunying; Feinstein Douglas; Huang Guo-Feng; Semah Frank; Mathis Chester A; Klunk William; Gould Robert M; Lubetzki Catherine; Zalc Bernard
Imaging of CNS myelin by positron-emission tomography.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(24):9304-9.
2006: de Leon Mony J; Klunk William
Biomarkers for the early diagnosis of Alzheimer's disease.
Lancet neurology 2006;5(3):198-9.
2006: Fagan Anne M; Mintun Mark A; Mach Robert H; Lee Sang-Yoon; Dence Carmen S; Shah Aarti R; LaRossa Gina N; Spinner Michael L; Klunk William E; Mathis Chester A; DeKosky Steven T; Morris John C; Holtzman David M
Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans.
Annals of neurology 2006;59(3):512-9.
2006: Thal Leon J; Kantarci Kejal; Reiman Eric M; Klunk William E; Weiner Michael W; Zetterberg Henrik; Galasko Douglas; Praticò Domenico; Griffin Sue; Schenk Dale; Siemers Eric
The role of biomarkers in clinical trials for Alzheimer disease.
Alzheimer disease and associated disorders 2006;20(1):6-15.
2006: Ikonomovic Milos D; Abrahamson Eric E; Isanski Barbara A; Debnath Manik L; Mathis Chester A; Dekosky Steven T; Klunk William E
X-34 labeling of abnormal protein aggregates during the progression of Alzheimer's disease.
Methods in enzymology 2006;412():123-44.
2005: Lopresti Brian J; Klunk William E; Mathis Chester A; Hoge Jessica A; Ziolko Scott K; Lu Xueling; Meltzer Carolyn C; Schimmel Kurt; Tsopelas Nicholas D; DeKosky Steven T; Price Julie C
Simplified quantification of Pittsburgh Compound B amyloid imaging PET studies: a comparative analysis.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2005;46(12):1959-72.
2005: Klunk William E; Lopresti Brian J; Ikonomovic Milos D; Lefterov Iliya M; Koldamova Radosveta P; Abrahamson Eric E; Debnath Manik L; Holt Daniel P; Huang Guo-feng; Shao Li; DeKosky Steven T; Price Julie C; Mathis Chester A
Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(46):10598-606.
2005: Price Julie C; Klunk William E; Lopresti Brian J; Lu Xueling; Hoge Jessica A; Ziolko Scott K; Holt Daniel P; Meltzer Carolyn C; DeKosky Steven T; Mathis Chester A
Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005;25(11):1528-47.
2005: Desai Purnima P; Ikonomovic Milos D; Abrahamson Eric E; Hamilton Ronald L; Isanski Barbara A; Hope Caroline E; Klunk William E; DeKosky Steven T; Kamboh M Ilyas
Apolipoprotein D is a component of compact but not diffuse amyloid-beta plaques in Alzheimer's disease temporal cortex.
Neurobiology of disease 2005;20(2):574-82.
2005: Morris John C; Kimberly A; Quaid K; Holtzman David M; Kantarci Kejal; Kaye Jeffrey; Reiman Eric M; Klunk William E; Siemers Eric R
Role of biomarkers in studies of presymptomatic Alzheimer's disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2005;1(2):145-51.
2005: Klunk William E
Commentary on "Diagnosis of Alzheimer's disease: Two decades of progress." Diagnosis of Alzheimer's disease: Walking a well-paved path.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2005;1(2):99-100.
2005: Buckner Randy L; Snyder Abraham Z; Shannon Benjamin J; LaRossa Gina; Sachs Rimmon; Fotenos Anthony F; Sheline Yvette I; Klunk William E; Mathis Chester A; Morris John C; Mintun Mark A
Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(34):7709-17.
2005: Nesterov Evgueni E; Skoch Jesse; Hyman Bradley T; Klunk William E; Bacskai Brian J; Swager Timothy M
In vivo optical imaging of amyloid aggregates in brain: design of fluorescent markers.
Angewandte Chemie (International ed. in English) 2005;44(34):5452-6.
2005: Matsuoka Yasuji; Shao Li; Debnath Manik; Lafrancois John; Becker Amanda; Gray Audrey; Aisen Paul; Mathis Chester; Klunk William; Duff Karen
An Abeta sequestration approach using non-antibody Abeta binding agents.
Current Alzheimer research 2005;2(2):265-8.
2005: Mathis Chester A; Klunk William E; Price Julie C; DeKosky Steven T
Imaging technology for neurodegenerative diseases: progress toward detection of specific pathologies.
Archives of neurology 2005;62(2):196-200.
2005: Brendza Robert P; Bacskai Brian J; Cirrito John R; Simmons Kelly A; Skoch Jesse M; Klunk William E; Mathis Chester A; Bales Kelly R; Paul Steven M; Hyman Bradley T; Holtzman David M
Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice.
The Journal of clinical investigation 2005;115(2):428-33.
2005: Lopez Oscar L; Becker James T; Saxton Judith; Sweet Robert A; Klunk William; DeKosky Steven T
Alteration of a clinically meaningful outcome in the natural history of Alzheimer's disease by cholinesterase inhibition.
Journal of the American Geriatrics Society 2005;53(1):83-7.
2004: Sadowski Marcin; Pankiewicz Joanna; Scholtzova Henrieta; Tsai Julia; Li Yongsheng; Carp Richard I; Meeker Harry C; Gambetti Pierluigi; Debnath Manik; Mathis Chester A; Shao Li; Gan Wen-Biao; Klunk William E; Wisniewski Thomas
Targeting prion amyloid deposits in vivo.
Journal of neuropathology and experimental neurology 2004;63(7):775-84.
2004: Klunk William E; Engler Henry; Nordberg Agneta; Wang Yanming; Blomqvist Gunnar; Holt Daniel P; Bergström Mats; Savitcheva Irina; Huang Guo-feng; Estrada Sergio; Ausén Birgitta; Debnath Manik L; Barletta Julien; Price Julie C; Sandell Johan; Lopresti Brian J; Wall Anders; Koivisto Pernilla; Antoni Gunnar; Mathis Chester A; Långström Bengt
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.
Annals of neurology 2004;55(3):306-19.
2004: Wang Yanming; Klunk William E; Debnath Manik L; Huang Guo-Feng; Holt Daniel P; Shao Li; Mathis Chester A
Development of a PET/SPECT agent for amyloid imaging in Alzheimer's disease.
Journal of molecular neuroscience : MN 2004;24(1):55-62.
2004: Mathis C A; Wang Y; Klunk W E
Imaging beta-amyloid plaques and neurofibrillary tangles in the aging human brain.
Current pharmaceutical design 2004;10(13):1469-92.
2003: Klunk William E; Engler Henry; Nordberg Agneta; Bacskai Brian J; Wang Yanming; Price Julie C; Bergström Mats; Hyman Bradley T; Långström Bengt; Mathis Chester A
Imaging the pathology of Alzheimer's disease: amyloid-imaging with positron emission tomography.
Neuroimaging clinics of North America 2003;13(4):781-9, ix.
2003: Kanski Jaroslaw; Sultana Rukhsana; Klunk William; Butterfield D Allan
Antioxidant activity of X-34 in synaptosomal and neuronal systems.
Brain research 2003;988(1-2):173-9.
2003: Bacskai Brian J; Hickey Gregory A; Skoch Jesse; Kajdasz Stephen T; Wang Yanming; Huang Guo-Feng; Mathis Chester A; Klunk William E; Hyman Bradley T
Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-beta ligand in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(21):12462-7.
2003: Mathis Chester A; Wang Yanming; Holt Daniel P; Huang Guo-Feng; Debnath Manik L; Klunk William E
Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents.
Journal of medicinal chemistry 2003;46(13):2740-54.
2003: Klunk William E; Wang Yanming; Huang Guo-feng; Debnath Manik L; Holt Daniel P; Shao Li; Hamilton Ronald L; Ikonomovic Milos D; DeKosky Steven T; Mathis Chester A
The binding of 2-(4'-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(6):2086-92.
2003: DeKosky Steven T; Ikonomovic Milos D; Wang Xiaoyan; Farlow Martin; Wisniewski Stephen; Lopez Oscar L; Becker James T; Saxton Judith; Klunk William E; Sweet Robert; Kaufer Daniel I; Kamboh M Ilyas
Plasma and cerebrospinal fluid alpha1-antichymotrypsin levels in Alzheimer's disease: correlation with cognitive impairment.
Annals of neurology 2003;53(1):81-90.
2003: Wang Yanming; Mathis Chester A; Huang Guo-Feng; Debnath Manik L; Holt Daniel P; Shao Li; Klunk William E
Effects of lipophilicity on the affinity and nonspecific binding of iodinated benzothiazole derivatives.
Journal of molecular neuroscience : MN 2003;20(3):255-60.
2003: Lopez Oscar L; Becker James T; Sweet Robert A; Klunk William; Kaufer Daniel I; Saxton Judith; Habeych Miguel; DeKosky Steven T
Psychiatric symptoms vary with the severity of dementia in probable Alzheimer's disease.
The Journal of neuropsychiatry and clinical neurosciences 2003;15(3):346-53.
2003: Lopez Oscar L; Becker James T; Sweet Robert A; Klunk William; Kaufer Daniel I; Saxton Judith; DeKosky Steven T
Patterns of change in the treatment of psychiatric symptoms in patients with probable Alzheimer's disease from 1983 to 2000.
The Journal of neuropsychiatry and clinical neurosciences 2003;15(1):67-73.
2002: Ishii Kazuhiro; Klunk William E; Arawaka Shigeki; Debnath Manik L; Furiya Yoshiko; Sahara Naruhiko; Shoji Shin'ichi; Tamaoka Akira; Pettegrew Jay W; Mori Hiroshi
Chrysamine G and its derivative reduce amyloid beta-induced neurotoxicity in mice.
Neuroscience letters 2002;333(1):5-8.
2002: Klunk William E; Bacskai Brian J; Mathis Chester A; Kajdasz Stephen T; McLellan Megan E; Frosch Matthew P; Debnath Manik L; Holt Daniel P; Wang Yanming; Hyman Bradley T
Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative.
Journal of neuropathology and experimental neurology 2002;61(9):797-805.
2002: Bacskai Brian J; Klunk William E; Mathis Chester A; Hyman Bradley T
Imaging amyloid-beta deposits in vivo.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(9):1035-41.
2002: Wang Yanming; Klunk William E; Huang Guo-Feng; Debnath Manik L; Holt Daniel P; Mathis Chester A
Synthesis and evaluation of 2-(3'-iodo-4'-aminophenyl)-6-hydroxybenzothiazole for in vivo quantitation of amyloid deposits in Alzheimer's disease.
Journal of molecular neuroscience : MN 2002;19(1-2):11-6.
2002: Sweet Robert A; Panchalingam Kanagasabai; Pettegrew Jay W; McClure Richard J; Hamilton Ronald L; Lopez Oscar L; Kaufer Daniel I; DeKosky Steven T; Klunk William E
Psychosis in Alzheimer disease: postmortem magnetic resonance spectroscopy evidence of excess neuronal and membrane phospholipid pathology.
Neurobiology of aging 2002;23(4):547-53.
2002: Klunk William E
Blood and CSF biomarkers for AD revisited: what's new, what's good, and is this where we should be looking?
Neurobiology of aging 2002;23(4):517-9; discussion 521-2.
2002: Whyte Ellen M; Mulsant Benoit H; Butters Meryl A; Qayyum Moshin; Towers Adele; Sweet Robert A; Klunk William; Wisniewski Steve; DeKosky Steven T
Cognitive and behavioral correlates of low vitamin B12 levels in elderly patients with progressive dementia.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2002;10(3):321-7.
2002: Mathis Chester A; Bacskai Brian J; Kajdasz Stephen T; McLellan Megan E; Frosch Matthew P; Hyman Bradley T; Holt Daniel P; Wang Yanming; Huang Guo-Feng; Debnath Manik L; Klunk William E
A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain.
Bioorganic & medicinal chemistry letters 2002;12(3):295-8.
2002: Lopez Oscar L; Becker James T; Kaufer Daniel I; Hamilton Ronald L; Sweet Robert A; Klunk William; DeKosky Steven T
Research evaluation and prospective diagnosis of dementia with Lewy bodies.
Archives of neurology 2002;59(1):43-6.
2002: Sweet Robert A; Kamboh M Ilyas; Wisniewski Stephen R; Lopez Oscar L; Klunk William E; Kaufer Daniel I; DeKosky Steven T
Apolipoprotein E and alpha-1-antichymotrypsin genotypes do not predict time to psychosis in Alzheimer's disease.
Journal of geriatric psychiatry and neurology 2002;15(1):24-30.
2001: Sweet R A; Pollock B G; Sukonick D L; Mulsant B H; Rosen J; Klunk W E; Kastango K B; DeKosky S T; Ferrell R E
The 5-HTTPR polymorphism confers liability to a combined phenotype of psychotic and aggressive behavior in Alzheimer disease.
International psychogeriatrics / IPA 2001;13(4):401-9.
2001: Smith D L; Portier R; Woodman B; Hockly E; Mahal A; Klunk W E; Li X J; Wanker E; Murray K D; Bates G P
Inhibition of polyglutamine aggregation in R6/2 HD brain slices-complex dose-response profiles.
Neurobiology of disease 2001;8(6):1017-26.
2001: Sukonick D L; Pollock B G; Sweet R A; Mulsant B H; Rosen J; Klunk W E; Kastango K B; DeKosky S T; Ferrell R E
The 5-HTTPR*S/*L polymorphism and aggressive behavior in Alzheimer disease.
Archives of neurology 2001;58(9):1425-8.
2001: Klunk W E; Wang Y; Huang G F; Debnath M L; Holt D P; Mathis C A
Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain.
Life sciences 2001;69(13):1471-84.
2001: Link C D; Johnson C J; Fonte V; Paupard M; Hall D H; Styren S; Mathis C A; Klunk W E
Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34.
Neurobiology of aging 2001;22(2):217-26.
2000: Sweet R A; Hamilton R L; Lopez O L; Klunk W E; Wisniewski S R; Kaufer D I; Healy M T; DeKosky S T
Psychotic symptoms in Alzheimer's disease are not associated with more severe neuropathologic features.
International psychogeriatrics / IPA 2000;12(4):547-58.
2000: Lopez O L; Becker J T; Klunk W; Saxton J; Hamilton R L; Kaufer D I; Sweet R A; Cidis Meltzer C; Wisniewski S; Kamboh M I; DeKosky S T
Research evaluation and diagnosis of possible Alzheimer's disease over the last two decades: II.
Neurology 2000;55(12):1863-9.
2000: Lopez O L; Becker J T; Klunk W; Saxton J; Hamilton R L; Kaufer D I; Sweet R A; Cidis Meltzer C; Wisniewski S; Kamboh M I; DeKosky S T
Research evaluation and diagnosis of probable Alzheimer's disease over the last two decades: I.
Neurology 2000;55(12):1854-62.
2000: Pettegrew J W; Klunk W E; Panchalingam K; McClure R J; Stanley J A
Molecular insights into neurodevelopmental and neurodegenerative diseases.
Brain research bulletin 2000;53(4):455-69.
2000: Styren S D; Hamilton R L; Styren G C; Klunk W E
X-34, a fluorescent derivative of Congo red: a novel histochemical stain for Alzheimer's disease pathology.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2000;48(9):1223-32.
1999: Lopez O L; Litvan I; Catt K E; Stowe R; Klunk W; Kaufer D I; Becker J T; DeKosky S T
Accuracy of four clinical diagnostic criteria for the diagnosis of neurodegenerative dementias.
Neurology 1999;53(6):1292-9.
1999: Klunk W E; Jacob R F; Mason R P
Quantifying amyloid beta-peptide (Abeta) aggregation using the Congo red-Abeta (CR-abeta) spectrophotometric assay.
Analytical biochemistry 1999;266(1):66-76.
1999: Klunk W E; Jacob R F; Mason R P
Quantifying amyloid by congo red spectral shift assay.
Methods in enzymology 1999;309():285-305.
1998: Klunk W E; Panchalingam K; McClure R J; Stanley J A; Pettegrew J W
Metabolic alterations in postmortem Alzheimer's disease brain are exaggerated by Apo-E4.
Neurobiology of aging 1998;19(6):511-5.
1998: Klunk W E
Biological markers of Alzheimer's disease.
Neurobiology of aging 1998;19(2):145-7.
1998: Klunk W E; Debnath M L; Koros A M; Pettegrew J W
Chrysamine-G, a lipophilic analogue of Congo red, inhibits A beta-induced toxicity in PC12 cells.
Life sciences 1998;63(20):1807-14.
1997: Xu C J; Kanfer J N; Klunk W E; Xiong Q; McClure R J; Pettegrew J W
Effect of phosphomonoesters, phosphodiesters, and phosphocreatine on glutamate uptake by synaptic vesicles.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1997;32(1-3):89-99.
1997: Pettegrew J W; Klunk W E; Panchalingam K; McClure R J; Stanley J A
Magnetic resonance spectroscopic changes in Alzheimer's disease.
Annals of the New York Academy of Sciences 1997;826():282-306.
1997: Klunk W E; Xu C J; McClure R J; Panchalingam K; Stanley J A; Pettegrew J W
Aggregation of beta-amyloid peptide is promoted by membrane phospholipid metabolites elevated in Alzheimer's disease brain.
Journal of neurochemistry 1997;69(1):266-72.
1996: Xu C J; Klunk W E; Kanfer J N; Xiong Q; Miller G; Pettegrew J W
Phosphocreatine-dependent glutamate uptake by synaptic vesicles. A comparison with atp-dependent glutamate uptake.
The Journal of biological chemistry 1996;271(23):13435-40.
1996: Klunk W E; Xu C; Panchalingam K; McClure R J; Pettegrew J W
Quantitative 1H and 31P MRS of PCA extracts of postmortem Alzheimer's disease brain.
Neurobiology of aging 1996;17(3):349-57.
1995: Pettegrew J W; Klunk W E; Kanal E; Panchalingam K; McClure R J
Changes in brain membrane phospholipid and high-energy phosphate metabolism precede dementia.
Neurobiology of aging 1995;16(6):973-5.
1995: Klunk W E; McClure R J; Xu C J; Pettegrew J W
Structural determinants of activity at the GABAB receptor. A comparison of phosphoethanolamine and related GABA analogs.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1995;26(1):15-30.
1995: Klunk W E; Debnath M L; Pettegrew J W
Chrysamine-G binding to Alzheimer and control brain: autopsy study of a new amyloid probe.
Neurobiology of aging 1995;16(4):541-8.
1995: McClure R J; Kanfer J N; Panchalingam K; Klunk W E; Pettegrew J W
Magnetic resonance spectroscopy and its application to aging and Alzheimer's disease.
Neuroimaging clinics of North America 1995;5(1):69-86.
1995: Pettegrew J W; Klunk W E; Panchalingam K; Kanfer J N; McClure R J
Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease.
Neurobiology of aging 1995;16(1):1-4.
1995: Klunk W E; Debnath M L; McClure R J; Pettegrew J W
Inactivity of phosphoethanolamine, an endogenous GABA analog decreased in Alzheimer's disease, at GABA binding sites.
Life sciences 1995;56(26):2377-83.
1994: McClure R J; Kanfer J N; Panchalingam K; Klunk W E; Pettegrew J W
Alzheimer's disease: membrane-associated metabolic changes.
Annals of the New York Academy of Sciences 1994;747():110-24.
1994: Klunk W E; Debnath M L; Pettegrew J W
Development of small molecule probes for the beta-amyloid protein of Alzheimer's disease.
Neurobiology of aging 1994;15(6):691-8.
1994: Lopez O L; Larumbe M R; Becker J T; Rezek D; Rosen J; Klunk W; DeKosky S T
Reliability of NINDS-AIREN clinical criteria for the diagnosis of vascular dementia.
Neurology 1994;44(7):1240-5.
1994: Klunk W E; Xu C J; Pettegrew J W
NMR identification of the formic acid-modified residue in Alzheimer's amyloid protein.
Journal of neurochemistry 1994;62(1):349-54.
1994: Klunk W E; Xu C J; Panchalingam K; McClure R J; Pettegrew J W
Analysis of magnetic resonance spectra by mole percent: comparison to absolute units.
Neurobiology of aging 1994;15(1):133-40.
1994: Pettegrew J W; Panchalingam K; Klunk W E; McClure R J; Muenz L R
Alterations of cerebral metabolism in probable Alzheimer's disease: a preliminary study.
Neurobiology of aging 1994;15(1):117-32.
1992: Klunk W E; Panchalingam K; Moossy J; McClure R J; Pettegrew J W
N-acetyl-L-aspartate and other amino acid metabolites in Alzheimer's disease brain: a preliminary proton nuclear magnetic resonance study.
Neurology 1992;42(8):1578-85.
1991: Klunk W E; McClure R J; Pettegrew J W
Possible roles of L-phosphoserine in the pathogenesis of Alzheimer's disease.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1991;15(1):51-73.
1991: Klunk W E; McClure R J; Pettegrew J W
L-phosphoserine, a metabolite elevated in Alzheimer's disease, interacts with specific L-glutamate receptor subtypes.
Journal of neurochemistry 1991;56(6):1997-2003.
1990: Klunk W E; Pettegrew J W
Alzheimer's beta-amyloid protein is covalently modified when dissolved in formic acid.
Journal of neurochemistry 1990;54(6):2050-6.
1989: Klunk W E; Pettegrew J W; Abraham D J
Two simple methods for quantifying low-affinity dye-substrate binding.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1989;37(8):1293-7.
1989: Klunk W E; Pettegrew J W; Abraham D J
Quantitative evaluation of congo red binding to amyloid-like proteins with a beta-pleated sheet conformation.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1989;37(8):1273-81.
1988: Klunk W E; Abraham D J
Filamentous proteins in Alzheimer's disease: new insights through molecular biology.
Psychiatric developments 1988;6(2):121-52.
1983: Ferrendelli J A; McKeon A C; Klunk W E
Effects of alkyl-substituted gamma-butyrolactones and succinimides on the evoked and spontaneous activity of hippocampal slices in vitro.
Experimental neurology 1983;82(3):663-74.
1983: Klunk W E; Covey D F; Ferrendelli J A
Alkyl-substituted gamma-butyrolactones as potential tools in the study and treatment of epilepsy.
Biochemical pharmacology 1983;32(20):2999-3004.
1983: Klunk W E; Kalman B L; Ferrendelli J A; Covey D F
Computer-assisted modeling of the picrotoxinin and gamma-butyrolactone receptor site.
Molecular pharmacology 1983;23(2):511-8.
1982: Klunk W E; Covey D F; Ferrendelli J A
Structure-activity relationships of alkyl-substituted gamma-butyrolactones and succinimides.
Molecular pharmacology 1982;22(2):444-50.
1982: Klunk W E; Covey D F; Ferrendelli J A
Anticonvulsant properties of alpha, gamma, and alpha, gamma-substituted gamma-butyrolactones.
Molecular pharmacology 1982;22(2):438-43.
1982: Klunk W E; Covey D F; Ferrendelli J A
Comparison of epileptogenic properties of unsubstituted and beta-alkyl-substituted gamma-butyrolactones.
Molecular pharmacology 1982;22(2):431-7.
1982: Klunk W E; McKeon A; Covey D F; Ferrendelli J A
Alpha-substituted gamma-butyrolactones: new class of anticonvulsant drugs.
Science (New York, N.Y.) 1982;217(4564):1040-2.

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