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Sven Klussmann

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Mohammad A Khan; Sven Klussmann; Lawrence L Leung; Christian Maasch; John Morser; Carl Atkinson; Peter S Heeger; Stephen Tomlinson; Axel Vater; Mark R Nicolls
Targeting complement component 5a promotes vascular integrity and limits airway remodeling.
Frank Schwoebel; Simone Sell; Lucas T van Eijk; Dirk Zboralski; Stefan Zöllner; Klaus Buchner; Dirk Eulberg; Martin Humphrey; Christian Maasch; Frank Morich; Peter Pickkers; Werner G Purschke; Sven Klussmann
The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys.
Rajkumar Savai; Axel Scheed; Werner Seeger; Axel Vater; Robert Voswinckel; Norbert Weissmann; Gamal-Andre Banat; Ewa Bieniek; Bhola K Dahal; Ludger Fink; Hossein A Ghofrani; Friedrich Grimminger; Walter Klepetko; Sven Klussmann; Julia Kolbe; Soni Pullamsetti; Christin Ritter; Ralph Theo Schermuly
Immune and inflammatory cell involvement in the pathology of idiopathic pulmonary arterial hypertension.

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All Publications

2013: Mohammad A Khan; Sven Klussmann; Lawrence L Leung; Christian Maasch; John Morser; Carl Atkinson; Peter S Heeger; Stephen Tomlinson; Axel Vater; Mark R Nicolls
Targeting complement component 5a promotes vascular integrity and limits airway remodeling.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(15):6061-6.
2013: Frank Schwoebel; Simone Sell; Lucas T van Eijk; Dirk Zboralski; Stefan Zöllner; Klaus Buchner; Dirk Eulberg; Martin Humphrey; Christian Maasch; Frank Morich; Peter Pickkers; Werner G Purschke; Sven Klussmann
The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys.
Blood 2013;121(12):2311-5.
2012: Rajkumar Savai; Axel Scheed; Werner Seeger; Axel Vater; Robert Voswinckel; Norbert Weissmann; Gamal-Andre Banat; Ewa Bieniek; Bhola K Dahal; Ludger Fink; Hossein A Ghofrani; Friedrich Grimminger; Walter Klepetko; Sven Klussmann; Julia Kolbe; Soni Pullamsetti; Christin Ritter; Ralph Theo Schermuly
Immune and inflammatory cell involvement in the pathology of idiopathic pulmonary arterial hypertension.
American journal of respiratory and critical care medicine 2012;186(9):897-908.
2012: Christer Baeck; Dirk Eulberg; Nikolaus Gassler; Felix Heymann; Sebastian Huss; Karlin Raja Karlmark; Sven Klussmann; Tom Luedde; Christian Trautwein; Mihael Vucur; Alexander Wehr; Frank Tacke
Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury.
Gut 2012;61(3):416-26.
2011: John J Turner; Stefan Vonhoff; Johannes S Hoos; Sven Klussmann
Methods for L-ribooligonucleotide sequence determination using LCMS.
Nucleic acids research 2011;39(21):e147.
2011: Stefanie Hoffmann; Johannes Hoos; Sven Klussmann; Stefan Vonhoff
RNA aptamers and spiegelmers: synthesis, purification, and post-synthetic PEG conjugation.
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2011;Chapter 4():Unit 4.46.1-30.
2011: Murthy N Darisipudi; Dirk Eulberg; Sven Klussmann; Onkar P Kulkarni; Adriana Migliorini; Eliana Parente; Paola Romagnani; Mi Ryu; Costanza Sagrinati; Sufyan G Sayyed; Axel Vater; Hans-Joachim Anders
Dual blockade of the homeostatic chemokine CXCL12 and the proinflammatory chemokine CCL2 has additive protective effects on diabetic kidney disease.
The American journal of pathology 2011;179(1):116-24.
2009: Onkar P Kulkarni; Dirk Eulberg; Norma Selve; Stefan Zöllner; Ramanjaneyulu Allam; Rahul Pawar; Stephanie Pfeiffer; Stephan Segerer; Sven Klussmann; Hans-Joachim Anders
Anti-Ccl2 Spiegelmer permits 75% dose reduction of cyclophosphamide to control diffuse proliferative lupus nephritis and pneumonitis in MRL-Fas(lpr) mice.
The Journal of pharmacology and experimental therapeutics 2009;328(2):371-7.
2008: Volha Ninichuk; Sebastian Clauss; Onkar P Kulkarni; Holger Schmid; Stephan Segerer; Ewa Radomska; Dirk Eulberg; Klaus Buchner; Norma Selve; Sven Klussmann; Hans-Joachim Anders
Late onset of Ccl2 blockade with the Spiegelmer mNOX-E36-3'PEG prevents glomerulosclerosis and improves glomerular filtration rate in db/db mice.
The American journal of pathology 2008;172(3):628-37.
2008: Christian Maasch; Klaus Buchner; Dirk Eulberg; Stefan Vonhoff; Sven Klussmann
Physicochemical stability of NOX-E36, a 40mer L-RNA (Spiegelmer) for therapeutic applications.
Nucleic acids symposium series (2004) 2008;(52):61-2.
2008: Csilla Becskei; K U Bilik; Sven Klussmann; Florian Jarosch; Thomas A Lutz; Thomas Riediger
The anti-ghrelin Spiegelmer NOX-B11-3 blocks ghrelin- but not fasting-induced neuronal activation in the hypothalamic arcuate nucleus.
Journal of neuroendocrinology 2008;20(1):85-92.
2007: Kerstin U Bilik; Elif Ergüven; Sven Klussmann; Florian Jarosch; Peter Y Wielinga; Thomas A Lutz; Thomas Riediger
In-vitro and in-vivo antagonistic action of an anti-amylin Spiegelmer.
Neuroreport 2007;18(17):1855-9.
2007: Onkar P Kulkarni; Rahul Pawar; Werner G Purschke; Dirk Eulberg; Norma Selve; Klaus Buchner; Volha Ninichuk; Stephan Segerer; Volker Vielhauer; Sven Klussmann; Hans-Joachim Anders
Spiegelmer inhibition of CCL2/MCP-1 ameliorates lupus nephritis in MRL-(Fas)lpr mice.
Journal of the American Society of Nephrology : JASN 2007;18(8):2350-8.
2006: Claudio Gnaccarini; Sascha Peter; Ute Scheffer; Stefan Vonhoff; Sven Klussmann; Michael W Göbel
Site-specific cleavage of RNA by a metal-free artificial nuclease attached to antisense oligonucleotides.
Journal of the American Chemical Society 2006;128(24):8063-7.
2006: Thomas Denekas; Markus Tröltzsch; Axel Vater; Sven Klussmann; Karl Messlinger
Inhibition of stimulated meningeal blood flow by a calcitonin gene-related peptide binding mirror-image RNA oligonucleotide.
British journal of pharmacology 2006;148(4):536-43.
2006: Peter Kobelt; Steffen Helmling; Andreas Stengel; Britta Wlotzka; Viola Andresen; Burghard F Klapp; Bertram Wiedenmann; Sven Klussmann; Hubert Mönnikes
Anti-ghrelin Spiegelmer NOX-B11 inhibits neurostimulatory and orexigenic effects of peripheral ghrelin in rats.
Gut 2006;55(6):788-92.
2006: Werner G Purschke; Dirk Eulberg; Klaus Buchner; Stefan Vonhoff; Sven Klussmann
An L-RNA-based aquaretic agent that inhibits vasopressin in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(13):5173-8.
2006: Lauren P Shearman; Sheng-Ping Wang; Steffen Helmling; D Sloan Stribling; Paul Mazur; Lan Ge; Liyang Wang; Sven Klussmann; D Euan MacIntyre; Andrew D Howard; Alison M Strack
Ghrelin neutralization by a ribonucleic acid-SPM ameliorates obesity in diet-induced obese mice.
Endocrinology 2006;147(3):1517-26.
2006: Florian Jarosch; Klaus Buchner; Sven Klussmann
In vitro selection using a dual RNA library that allows primerless selection.
Nucleic acids research 2006;34(12):e86.
2006: Steffen Helmling; Florian Jarosch; Sven Klussmann
The promise of ghrelin antagonism in obesity treatment.
Drug news & perspectives 2006;19(1):13-20.
2005: Jeffrey S Mogil; Frank Miermeister; frank seifert; Kate Strasburg; Katharina Zimmermann; Heiko Reinold; Jean-Sebastien Austin; Nadia Bernardini; Elissa J Chesler; Heiko A Hofmann; Christian Hordo; Karl Messlinger; Kumar V S Nemmani; Andrew L Rankin; Jennifer Ritchie; Angela Siegling; Shad B Smith; Susana G Sotocinal; Axel Vater; Sonya G Lehto; Sven Klussmann; Rémi Quirion; Martin Michaelis; Marshall Devor; Peter W Reeh
Variable sensitivity to noxious heat is mediated by differential expression of the CGRP gene.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(36):12938-43.
2005: Michael Gröschl; Hans-Georg Topf; Jörg Bohlender; Johannes Zenk; Sven Klussmann; Jörg Dötsch; Wolfgang Rascher; Manfred Rauh
Identification of ghrelin in human saliva: production by the salivary glands and potential role in proliferation of oral keratinocytes.
Clinical chemistry 2005;51(6):997-1006.
2005: Raphaël Boisgard; Bertrand Kuhnast; Stefan Vonhoff; Chéraz Younes; Françoise Hinnen; Jean-Marc Verbavatz; Bernard Rousseau; Jens P Fürste; Britta Wlotzka; Frédéric Dollé; Sven Klussmann; Bertrand Tavitian
In vivo biodistribution and pharmacokinetics of 18F-labelled Spiegelmers: a new class of oligonucleotidic radiopharmaceuticals.
European journal of nuclear medicine and molecular imaging 2005;32(4):470-7.
2005: Dirk Eulberg; Klaus Buchner; Christian Maasch; Sven Klussmann
Development of an automated in vitro selection protocol to obtain RNA-based aptamers: identification of a biostable substance P antagonist.
Nucleic acids research 2005;33(4):e45.
2004: Steffen Helmling; Christian Maasch; Dirk Eulberg; Klaus Buchner; Werner Schröder; Christian Lange; Stefan Vonhoff; Britta Wlotzka; Matthias H Tschöp; Stefan Rosewicz; Sven Klussmann
Inhibition of ghrelin action in vitro and in vivo by an RNA-Spiegelmer.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(36):13174-9.
2004: Dirk Faulhammer; Bernd Eschgfäller; Sandra Stark; Petra Burgstaller; Werner Englberger; Jeannette Erfurth; Frank Kleinjung; Johanna Rupp; Sebastian Dan Vulcu; Werner Schröder; Stefan Vonhoff; Hermann Nawrath; Clemens Gillen; Sven Klussmann
Biostable aptamers with antagonistic properties to the neuropeptide nociceptin/orphanin FQ.
RNA (New York, N.Y.) 2004;10(3):516-27.
2003: Axel Vater; Florian Jarosch; Klaus Buchner; Sven Klussmann
Short bioactive Spiegelmers to migraine-associated calcitonin gene-related peptide rapidly identified by a novel approach: tailored-SELEX.
Nucleic acids research 2003;31(21):e130.
2003: Dirk Eulberg; Sven Klussmann
Spiegelmers: biostable aptamers.
Chembiochem : a European journal of chemical biology 2003;4(10):979-83.
2003: Thomas Schoetzau; Josmar Langner; Elisabeth Moyroud; Ingo Roehl; Stefan Vonhoff; Sven Klussmann
Aminomodified nucleobases: functionalized nucleoside triphosphates applicable for SELEX.
Bioconjugate chemistry 2003;14(5):919-26.
2003: Werner G Purschke; Falko Radtke; Frank Kleinjung; Sven Klussmann
A DNA Spiegelmer to staphylococcal enterotoxin B.
Nucleic acids research 2003;31(12):3027-32.
2003: Th Schoetzau; Josmar Langner; Elisabeth Moyroud; I Röhl; Sven Klussmann; Stefan Vonhoff
Modified nucleoside triphosphates: synthesis and applications for RNA in vitro selection.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1293-6.
2003: Steffen Helmling; Elisabeth Moyroud; W Schroeder; I Roehl; Frank Kleinjung; S Stark; Gregor Bahrenberg; Clemens Gillen; Sven Klussmann; Stefan Vonhoff
A new class of Spiegelmers containing 2'-fluoro-nucleotides.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1035-8.
2003: Josmar Langner; Sven Klussmann
PCR primers containing stop codons reduce the number of false-negatives during blue-white screening.
BioTechniques 2003;34(5):950-2, 954.
2003: Christian Frauendorf; Felix Hausch; Ingo Röhl; Andrea Lichte; Stefan Vonhoff; Sven Klussmann
Internal 32P-labeling of L-deoxyoligonucleotides.
Nucleic acids research 2003;31(7):e34.
2003: Axel Vater; Sven Klussmann
Toward third-generation aptamers: Spiegelmers and their therapeutic prospects.
Current opinion in drug discovery & development 2003;6(2):253-61.
2003: Nicole Wehofsky; Sven Thust; Jens Burmeister; Sven Klussmann; Frank Bordusa
all-D-Polypeptides: novel targets for semisynthesis.
Angewandte Chemie (International ed. in English) 2003;42(6):677-9.
2002: Britta Wlotzka; Susanne Leva; Bernd Eschgfäller; Jens Burmeister; Frank Kleinjung; Christine Kaduk; Peter Muhn; Holger Hess-Stumpp; Sven Klussmann
In vivo properties of an anti-GnRH Spiegelmer: an example of an oligonucleotide-based therapeutic substance class.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(13):8898-902.
2002: Susanne Leva; Andrea Lichte; Jens Burmeister; Peter Muhn; Birgit Jahnke; Dirk Fesser; Jeannette Erfurth; Petra Burgstaller; Sven Klussmann
GnRH binding RNA and DNA Spiegelmers: a novel approach toward GnRH antagonism.
Chemistry & biology 2002;9(3):351-9.