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Jeffrey Knauf

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Cristina Montero-Conde; Neal Rosen; Sergio Ruiz-Llorente; Mabel Ryder; Eric J Sherman; Agnes Viale; Jose M Dominguez; Ronald A Ghossein; Jeffrey A Knauf; James A Fagin
Relief of Feedback Inhibition of HER3 Transcription by RAF and MEK Inhibitors Attenuates Their Antitumor Effects in BRAF-Mutant Thyroid Carcinomas.
Debyani Chakravarty; Gideon Bollag; Ronald Ghossein; Jeffrey A Knauf; Richard Kolesnick; Steven M Larson; Xiao-Hui Liao; Samuel Refetoff; Neal Rosen; Mabel Ryder; Elmer Santos; Tin Htwe Thin; Brian L West; Pat Zanzonico; James A Fagin
Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation.
Mickey Croyle; Nagako Akeno; Jeffrey A Knauf; Doriano Fabbro; Xu Chen; Jacqueline E Baumgartner; Heidi A Lane; James A Fagin
RET/PTC-induced cell growth is mediated in part by epidermal growth factor receptor (EGFR) activation: evidence for molecular and functional interactions between RET and EGFR.

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All Publications

2013: Cristina Montero-Conde; Neal Rosen; Sergio Ruiz-Llorente; Mabel Ryder; Eric J Sherman; Agnes Viale; Jose M Dominguez; Ronald A Ghossein; Jeffrey A Knauf; James A Fagin
Relief of Feedback Inhibition of HER3 Transcription by RAF and MEK Inhibitors Attenuates Their Antitumor Effects in BRAF-Mutant Thyroid Carcinomas.
Cancer discovery 2013;3(5):520-33.
2011: Debyani Chakravarty; Gideon Bollag; Ronald Ghossein; Jeffrey A Knauf; Richard Kolesnick; Steven M Larson; Xiao-Hui Liao; Samuel Refetoff; Neal Rosen; Mabel Ryder; Elmer Santos; Tin Htwe Thin; Brian L West; Pat Zanzonico; James A Fagin
Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation.
The Journal of clinical investigation 2011;121(12):4700-11.
2008: Mickey Croyle; Nagako Akeno; Jeffrey A Knauf; Doriano Fabbro; Xu Chen; Jacqueline E Baumgartner; Heidi A Lane; James A Fagin
RET/PTC-induced cell growth is mediated in part by epidermal growth factor receptor (EGFR) activation: evidence for molecular and functional interactions between RET and EGFR.
Cancer research 2008;68(11):4183-91.
2007: Nagako Akeno-Stuart; Mickey Croyle; Jeffrey A Knauf; Roberta Malaguarnera; Donata Vitagliano; Massimo Santoro; Christine Stephan; Konstantina Grosios; Markus Wartmann; Robert Cozens; Giorgio Caravatti; Doriano Fabbro; Heidi A Lane; James A Fagin
The RET kinase inhibitor NVP-AST487 blocks growth and calcitonin gene expression through distinct mechanisms in medullary thyroid cancer cells.
Cancer research 2007;67(14):6956-64.
2006: Cleo Mesa; mana mirza; Norisato Mitsutake; Maureen Sartor; Mario Medvedovic; Craig R Tomlinson; Jeffrey A Knauf; Georg F Weber; James A Fagin
Conditional activation of RET/PTC3 and BRAFV600E in thyroid cells is associated with gene expression profiles that predict a preferential role of BRAF in extracellular matrix remodeling.
Cancer research 2006;66(13):6521-9.
2006: Bin Ouyang; Jeffrey A Knauf; Eric P Smith; Lei Zhang; Tim Ramsey; Naeem Yusuff; David Batt; James A Fagin
Inhibitors of Raf kinase activity block growth of thyroid cancer cells with RET/PTC or BRAF mutations in vitro and in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(6):1785-93.
2006: Jeffrey A Knauf; Bin Ouyang; Erik S Knudsen; Kenji Fukasawa; George Babcock; James A Fagin
Oncogenic RAS induces accelerated transition through G2/M and promotes defects in the G2 DNA damage and mitotic spindle checkpoints.
The Journal of biological chemistry 2006;281(7):3800-9.
2006: Norisato Mitsutake; Makoto Miyagishi; Shin Mitsutake; Nagako Akeno; Cleo Mesa; Jeffrey A Knauf; Lei Zhang; Kazunari Taira; James A Fagin
BRAF mediates RET/PTC-induced mitogen-activated protein kinase activation in thyroid cells: functional support for requirement of the RET/PTC-RAS-BRAF pathway in papillary thyroid carcinogenesis.
Endocrinology 2006;147(2):1014-9.
2005: Efisio Puxeddu; Jeffrey A Knauf; Maureen Sartor; Norisato Mitsutake; Eric P Smith; Mario Medvedovic; Craig R Tomlinson; Sonia Moretti; James A Fagin
RET/PTC-induced gene expression in thyroid PCCL3 cells reveals early activation of genes involved in regulation of the immune response.
Endocrine-related cancer 2005;12(2):319-34.
2005: Jeffrey A Knauf; Xiaolan Ma; Eric P Smith; Lei Zhang; Norisato Mitsutake; Xiao-Hui Liao; Samuel Refetoff; Yuri E Nikiforov; James A Fagin
Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation.
Cancer research 2005;65(10):4238-45.
2005: Raffaele Ciampi; Jeffrey A Knauf; Hartmut M Rabes; James A Fagin; Yuri E Nikiforov
BRAF kinase activation via chromosomal rearrangement in radiation-induced and sporadic thyroid cancer.
Cell cycle (Georgetown, Tex.) 2005;4(4):547-8.
2005: Norisato Mitsutake; Jeffrey A Knauf; Shin Mitsutake; Cleo Mesa; Lei Zhang; James A Fagin
Conditional BRAFV600E expression induces DNA synthesis, apoptosis, dedifferentiation, and chromosomal instability in thyroid PCCL3 cells.
Cancer research 2005;65(6):2465-73.
2005: Raffaele Ciampi; Jeffrey A Knauf; Roswitha Kerler; Manoj Gandhi; Zhaowen Zhu; Marina N Nikiforova; Hartmut M Rabes; James A Fagin; Yuri E Nikiforov
Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer.
The Journal of clinical investigation 2005;115(1):94-101.
2004: Marina N Nikiforova; Raffaele Ciampi; Giuliana Salvatore; Massimo Santoro; Manoj Gandhi; Jeffrey A Knauf; Gerry A Thomas; Steve Jeremiah; Tetyana I Bogdanova; Mykola D Tronko; James A Fagin; Yuri E Nikiforov
Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas.
Cancer letters 2004;209(1):1-6.
2003: Efisio Puxeddu; Norisato Mitsutake; Jeffrey A Knauf; Sonia Moretti; Hei W Kim; Karen A Seta; Diane E Brockman; Leslie Myatt; David E Millhorn; James A Fagin
Microsomal prostaglandin E2 synthase-1 is induced by conditional expression of RET/PTC in thyroid PCCL3 cells through the activation of the MEK-ERK pathway.
The Journal of biological chemistry 2003;278(52):52131-8.
2003: Marina N Nikiforova; Edna T Kimura; Manoj Gandhi; Paul Williams Biddinger; Jeffrey A Knauf; Fulvio Basolo; Zhaowen Zhu; Riccardo Giannini; Giuliana Salvatore; Alfredo Fusco; Massimo Santoro; James A Fagin; Yuri E Nikiforov
BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas.
The Journal of clinical endocrinology and metabolism 2003;88(11):5399-404.
2003: Jeffrey A Knauf; Bin Ouyang; Mickey Croyle; Edna Kimura; James A Fagin
Acute expression of RET/PTC induces isozyme-specific activation and subsequent downregulation of PKCepsilon in PCCL3 thyroid cells.
Oncogene 2003;22(44):6830-8.
2003: Jeffrey A Knauf; Hiroaki Kuroda; Saswata Basu; James A Fagin
RET/PTC-induced dedifferentiation of thyroid cells is mediated through Y1062 signaling through SHC-RAS-MAP kinase.
Oncogene 2003;22(28):4406-12.
2003: Jianwei Wang; Jeffrey A Knauf; Saswata Basu; Efisio Puxeddu; Hiroaki Kuroda; Massimo Santoro; Alfredo Fusco; James A Fagin
Conditional expression of RET/PTC induces a weak oncogenic drive in thyroid PCCL3 cells and inhibits thyrotropin action at multiple levels.
Molecular endocrinology (Baltimore, Md.) 2003;17(7):1425-36.
2003: Edna T Kimura; Marina N Nikiforova; Zhaowen Zhu; Jeffrey A Knauf; Yuri E Nikiforov; James A Fagin
High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma.
Cancer research 2003;63(7):1454-7.
2002: Jeffrey A Knauf; Laura S Ward; Yuri E Nikiforov; Marina N Nikiforova; Efisio Puxeddu; Mario Medvedovic; Tamar Liron; Daria Mochly-Rosen; James A Fagin
Isozyme-specific abnormalities of PKC in thyroid cancer: evidence for post-transcriptional changes in PKC epsilon.
The Journal of clinical endocrinology and metabolism 2002;87(5):2150-9.
2002: Bin Ouyang; Jeffrey A Knauf; Kenneth B Ain; Benjamin Nacev; James A Fagin
Mechanisms of aneuploidy in thyroid cancer cell lines and tissues: evidence for mitotic checkpoint dysfunction without mutations in BUB1 and BUBR1.
Clinical endocrinology 2002;56(3):341-50.
2001: Daria Mochly-Rosen; James A Fagin; Jeffrey A Knauf; Yuri E Nikiforov; Tamar Liron; Deborah Schechtman
Spontaneous occurrence of an inhibitor of protein kinase C localization in a thyroid cancer cell line: role in thyroid tumorigenesis.
Advances in enzyme regulation 2001;41():87-97.
2000: J M Shirokawa; R Elisei; Jeffrey A Knauf; T Hara; Jianwei Wang; Harold I Saavedra; James A Fagin
Conditional apoptosis induced by oncogenic ras in thyroid cells.
Molecular endocrinology (Baltimore, Md.) 2000;14(11):1725-38.
2000: Harold I Saavedra; Jeffrey A Knauf; J M Shirokawa; Jianwei Wang; Bin Ouyang; R Elisei; Peter J Stambrook; James A Fagin
The RAS oncogene induces genomic instability in thyroid PCCL3 cells via the MAPK pathway.
Oncogene 2000;19(34):3948-54.
1999: Jeffrey A Knauf; R Elisei; Daria Mochly-Rosen; Tamar Liron; Xiao-Ning Chen; R Gonsky; Julie R Korenberg; James A Fagin
Involvement of protein kinase Cepsilon (PKCepsilon) in thyroid cell death. A truncated chimeric PKCepsilon cloned from a thyroid cancer cell line protects thyroid cells from apoptosis.
The Journal of biological chemistry 1999;274(33):23414-25.
1998: X Chen; Jeffrey A Knauf; R Gonsky; M Wang; E H Lai; S Chissoe; James A Fagin; Julie R Korenberg
From amplification to gene in thyroid cancer: a high-resolution mapped bacterial-artificial-chromosome resource for cancer chromosome aberrations guides gene discovery after comparative genome hybridization.
American journal of human genetics 1998;63(2):625-37.
1997: R Gonsky; Jeffrey A Knauf; R Elisei; J W Wang; S Su; James A Fagin
Identification of rapid turnover transcripts overexpressed in thyroid tumors and thyroid cancer cell lines: use of a targeted differential RNA display method to select for mRNA subsets.
Nucleic acids research 1997;25(19):3823-31.