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Edward Knaus

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TOP 3
Atul Bhardwaj; Zhangjian Huang; Jatinder Kaur; John M Seubert; Fenghua Yang; Edward E Knaus
A diazen-1-ium-1,2-diolate analog of 7-azabenzobicyclo[2.2.1]heptane: Synthesis, nitric oxide and nitroxyl release, in vitro hemodynamic, and anti-hypertensive studies.
Atul Bhardwaj; Jatinder Kaur; Edward E Knaus
Can nitric oxide-releasing hybrid drugs alleviate adverse cardiovascular risks?
Atul Bhardwaj; Zhangjian Huang; Jatinder Kaur; Sai Kiran Sharma; Frank Wuest; Edward E Knaus
Hybrid fluorescent conjugates of COX-2 inhibitors: search for a COX-2 isozyme imaging cancer biomarker.

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2013: Atul Bhardwaj; Zhangjian Huang; Jatinder Kaur; John M Seubert; Fenghua Yang; Edward E Knaus
A diazen-1-ium-1,2-diolate analog of 7-azabenzobicyclo[2.2.1]heptane: Synthesis, nitric oxide and nitroxyl release, in vitro hemodynamic, and anti-hypertensive studies.
Bioorganic & medicinal chemistry letters 2013;23(9):2769-74.
2013: Atul Bhardwaj; Jatinder Kaur; Edward E Knaus
Can nitric oxide-releasing hybrid drugs alleviate adverse cardiovascular risks?
Future medicinal chemistry 2013;5(4):381-3.
2013: Atul Bhardwaj; Zhangjian Huang; Jatinder Kaur; Sai Kiran Sharma; Frank Wuest; Edward E Knaus
Hybrid fluorescent conjugates of COX-2 inhibitors: search for a COX-2 isozyme imaging cancer biomarker.
Bioorganic & medicinal chemistry letters 2013;23(1):163-8.
2012: Zhangjian Huang; Jatinder Kaur; S Bruce King; Nasser Alsaleh; Atul Bhardwaj; Jenna F DuMond; Julie A Reisz; John M Seubert; Yihua Zhang; Edward E Knaus
O2-sulfonylethyl protected isopropylamine diazen-1-ium-1,2-diolates as nitroxyl (HNO) donors: synthesis, β-elimination fragmentation, HNO release, positive inotropic properties, and blood pressure lowering studies.
Journal of medicinal chemistry 2012;55(22):10262-71.
2012: Jatinder Kaur; Atul Bhardwaj; Ting-Yueh Chen; Zhangjian Huang; Deepak Narang; Frances Plane; Edward E Knaus
Synthesis and biological investigations of nitric oxide releasing nateglinide and meglitinide type II antidiabetic prodrugs: in-vivo antihyperglycemic activities and blood pressure lowering studies.
Journal of medicinal chemistry 2012;55(17):7883-91.
2012: Atul Bhardwaj; Zhangjian Huang; Jatinder Kaur; Sri N Batchu; John M Seubert; Edward E Knaus
Cardiovascular properties of a nitric oxide releasing rofecoxib analogue: beneficial anti-hypertensive activity and enhanced recovery in an ischemic reperfusion injury model.
ChemMedChem 2012;7(8):1365-8.
2012: Jatinder Kaur; Atul Bhardwaj; Zhangjian Huang; Edward E Knaus
N-1 and C-3 substituted indole Schiff bases as selective COX-2 inhibitors: synthesis and biological evaluation.
Bioorganic & medicinal chemistry letters 2012;22(6):2154-9.
2012: Leonard I Wiebe; Jennifer Yang; Aihua Zhou; Carol E Cass; Staffan Eriksson; Piyush Kumar; Robert J Paproski; Elena V Sjuvarsson; William Sun; Edward E Knaus
Biochemistry and biology of 2'-Fluoro-2'-deoxythymidine (FT), a putative highly selective substrate for thymidine kinase type 2 (TK2).
Current radiopharmaceuticals 2012;5(1):38-46.
2011: M Abdur Rahim; Atul Bhardwaj; Zhangjian Huang; Jatinder Kaur; PN Praveen Rao; Edward E Knaus
Isomeric acetoxy analogs of celecoxib and their evaluation as cyclooxygenase inhibitors.
Bioorganic & medicinal chemistry letters 2011;21(20):6074-80.
2011: Edward E Knaus; Andrea Scozzafava; Alessio Innocenti; Claudiu T Supuran
Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II.
Bioorganic & medicinal chemistry letters 2011;21(19):5892-6.
2011: Khaled R A Abdellatif; Morshed A Chowdhury; Zhangjian Huang; Susan Kaufman; Edward E Knaus
A diazen-1-ium-1,2-diolated nitric oxide donor ester prodrug of 3-(4-hydroxymethylphenyl)-4-(4-methanesulfonylphenyl)-5H-furan-2-one: synthesis, biological evaluation and nitric oxide release studies.
Bioorganic & medicinal chemistry letters 2011;21(13):3951-6.
2011: Zhangjian Huang; Carlos Velázquez; Khaled R A Abdellatif; Morshed A Chowdhury; Julie A Reisz; Jenna F DuMond; S Bruce King; Edward E Knaus
Ethanesulfohydroxamic acid ester prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs): synthesis, nitric oxide and nitroxyl release, cyclooxygenase inhibition, anti-inflammatory, and ulcerogenicity index studies.
Journal of medicinal chemistry 2011;54(5):1356-64.
2011: Zhangjian Huang; Edward E Knaus
O2-(N-hydroxy(methoxy)-2-ethanesulfonamido) protected diazen-1-ium-1,2-diolates: nitric oxide release via a base-induced β-elimination cleavage.
Organic letters 2011;13(5):1178-81.
2011: Khaled R A Abdellatif; Carlos Velázquez; Zhangjian Huang; Morshed A Chowdhury; Edward E Knaus
Triaryl (Z)-olefins suitable for radiolabeling with iodine-124 or fluorine-18 radionuclides for positron emission tomography imaging of estrogen positive breast tumors.
Bioorganic & medicinal chemistry letters 2011;21(4):1195-8.
2010: Morshed A Chowdhury; Zhangjian Huang; Khaled R A Abdellatif; Ying Dong; Gang Yu; Carlos Velázquez; Edward E Knaus
Synthesis and biological evaluation of indomethacin analogs possessing a N-difluoromethyl-1,2-dihydropyrid-2-one ring system: a search for novel cyclooxygenase and lipoxygenase inhibitors.
Bioorganic & medicinal chemistry letters 2010;20(19):5776-80.
2010: Khaled R A Abdellatif; Carlos Velázquez; Zhangjian Huang; Morshed A Chowdhury; Edward E Knaus
Triaryl (Z)-olefins suitable for radiolabeling with carbon-11 or fluorine-18 radionuclides for positron emission tomography imaging of cyclooxygenase-2 expression in pathological disease.
Bioorganic & medicinal chemistry letters 2010;20(17):5245-50.
2010: Khaled R A Abdellatif; Morshed A Chowdhury; Carlos Velázquez; Zhangjian Huang; Ying Dong; Dipankar Das; Gang Yu; Mavanur R Suresh; Edward E Knaus
Celecoxib prodrugs possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies.
Bioorganic & medicinal chemistry letters 2010;20(15):4544-9.
2010: Gang Yu; PN Praveen Rao; Morshed A Chowdhury; Khaled R A Abdellatif; Ying Dong; Dipankar Das; Carlos Velázquez; Mavanur R Suresh; Edward E Knaus
Synthesis and biological evaluation of N-difluoromethyl-1,2-dihydropyrid-2-one acetic acid regioisomers: dual inhibitors of cyclooxygenases and 5-lipoxygenase.
Bioorganic & medicinal chemistry letters 2010;20(7):2168-73.
2010: Morshed A Chowdhury; Khaled R A Abdellatif; Ying Dong; Gang Yu; Zhangjian Huang; Moshfiqur Rahman; Dipankar Das; Carlos Velázquez; Mavanur R Suresh; Edward E Knaus
Celecoxib analogs possessing a N-(4-nitrooxybutyl)piperidin-4-yl or N-(4-nitrooxybutyl)-1,2,3,6-tetrahydropyridin-4-yl nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies.
Bioorganic & medicinal chemistry letters 2010;20(4):1324-9.
2010: Gang Yu; Morshed A Chowdhury; Khaled R A Abdellatif; Ying Dong; PN Praveen Rao; Dipankar Das; Carlos Velázquez; Mavanur R Suresh; Edward E Knaus
Phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.
Bioorganic & medicinal chemistry letters 2010;20(3):896-902.
2009: Morshed A Chowdhury; Khaled R A Abdellatif; Ying Dong; Dipankar Das; Gang Yu; Carlos Velázquez; Mavanur R Suresh; Edward E Knaus
Synthesis and biological evaluation of salicylic acid and N-acetyl-2-carboxybenzenesulfonamide regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.
Bioorganic & medicinal chemistry letters 2009;19(24):6855-61.
2009: Khaled R A Abdellatif; Morshed Alam Chowdhury; Ying Dong; Dipankar Das; Gang Yu; Carlos Velázquez; Mavanur R Suresh; Edward E Knaus
Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-carboxymethylphenyl)-1-(4-methanesulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its aminosulfonyl analog: Synthesis, biological evaluation and nitric oxide release studies.
Bioorganic & medicinal chemistry 2009;17(14):5182-8.
2009: Khaled R A Abdellatif; Morshed Alam Chowdhury; Ying Dong; Dipankar Das; Gang Yu; Carlos Velázquez; Mavanur R Suresh; Edward E Knaus
Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: synthesis, biological evaluation and nitric oxide release studies.
Bioorganic & medicinal chemistry letters 2009;19(11):3014-8.
2009: Morshed A Chowdhury; Khaled R A Abdellatif; Ying Dong; Dipankar Das; Mavanur R Suresh; Edward E Knaus
Synthesis of celecoxib analogues possessing a N-difluoromethyl-1,2-dihydropyrid-2-one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.
Journal of medicinal chemistry 2009;52(6):1525-9.
2009: Morshed Alam Chowdhury; Khaled R A Abdellatif; Ying Dong; Moshfiqur Rahman; Dipankar Das; Mavanur R Suresh; Edward E Knaus
Synthesis of 1-(methanesulfonyl- and aminosulfonylphenyl)acetylenes that possess a 2-(N-difluoromethyl-1,2-dihydropyridin-2-one) pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.
Bioorganic & medicinal chemistry letters 2009;19(3):584-8.
2008: Morshed Alam Chowdhury; Khaled R A Abdellatif; Ying Dong; Dipankar Das; Mavanur R Suresh; Edward E Knaus
Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2(1H)one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.
Bioorganic & medicinal chemistry letters 2008;18(23):6138-41.
2008: Khaled R A Abdellatif; Morshed Alam Chowdhury; Ying Dong; Carlos Velázquez; Dipankar Das; Mavanur R Suresh; Edward E Knaus
Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-hydroxymethylphenyl)-1-(4-aminosulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its methanesulfonyl analog: synthesis, biological evaluation and nitric oxide release studies.
Bioorganic & medicinal chemistry 2008;16(22):9694-8.
2008: Morshed Alam Chowdhury; Khaled R A Abdellatif; Ying Dong; Edward E Knaus
Synthesis of new 4-[2-(4-methyl(amino)sulfonylphenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-1,2,3,6-tetrahydropyridines: a search for novel nitric oxide donor anti-inflammatory agents.
Bioorganic & medicinal chemistry 2008;16(19):8882-8.
2008: Erin M MacKenzie; Afshin Fassihi; Asghar Davood; Qiao-Hong Chen; Gillian Rauw; Gail Rauw; Edward E Knaus; Glen B Baker
N-Propynyl analogs of beta-phenylethylidenehydrazines: synthesis and evaluation of effects on glycine, GABA, and monoamine oxidase.
Bioorganic & medicinal chemistry 2008;16(17):8254-63.
2008: Morshed Alam Chowdhury; Hua Chen; Khaled R A Abdellatif; Ying Dong; Kenneth C Petruk; Edward E Knaus
Synthesis and biological evaluation of 1-(benzenesulfonamido)-2-[5-(N-hydroxypyridin-2(1H)-one)]acetylene regioisomers: a novel class of 5-lipoxygenase inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(14):4195-8.
2008: Khaled R A Abdellatif; Morshed Alam Chowdhury; Ying Dong; Edward E Knaus
Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 1-(4-methanesulfonylphenyl)-5-aryl-1H-pyrazol-3-carboxylic acids: synthesis, nitric oxide release studies and anti-inflammatory activities.
Bioorganic & medicinal chemistry 2008;16(13):6528-34.
2008: Carlos Velázquez; Qiao-Hong Chen; Michael L Citro; Larry K Keefer; Edward E Knaus
Second-generation aspirin and indomethacin prodrugs possessing an O(2)-(acetoxymethyl)-1-(2-carboxypyrrolidin-1-yl)diazenium-1,2-diolate nitric oxide donor moiety: design, synthesis, biological evaluation, and nitric oxide release studies.
Journal of medicinal chemistry 2008;51(6):1954-61.
2008: Khaled R A Abdellatif; Morshed Alam Chowdhury; Ying Dong; Qiao-Hong Chen; Edward E Knaus
Diazen-1-ium-1,2-diolated and nitrooxyethyl nitric oxide donor ester prodrugs of anti-inflammatory (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic acids: synthesis, cyclooxygenase inhibition, and nitric oxide release studies.
Bioorganic & medicinal chemistry 2008;16(6):3302-8.
2008: Morshed Alam Chowdhury; Ying Dong; Qiao-Hong Chen; Khaled R A Abdellatif; Edward E Knaus
Synthesis and cyclooxygenase inhibitory activities of linear 1-(methanesulfonylphenyl or benzenesulfonamido)-2-(pyridyl)acetylene regioisomers.
Bioorganic & medicinal chemistry 2008;16(4):1948-56.
2008: H-F Li; Alexandra Winkeler; Sameh Moharram; Edward E Knaus; K Dittmar; M Stöckle; Wolf-Dieter Heiss; Leonard I Wiebe; A H Jacobs; A J Jacob
In vivo evaluation of the uptake of [(123)I]FIAU, [(123)I]IVFRU and [(123)I]IVFAU by normal mouse brain: potential for noninvasive assessment of HSV-1 thymidine kinase gene expression in gliomas.
Nucleosides, nucleotides & nucleic acids 2008;27(1):57-66.
2007: Khaled R A Abdellatif; Ying Dong; Qiao-Hong Chen; Morshed Alam Chowdhury; Edward E Knaus
Novel (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic ester prodrugs possessing a diazen-1-ium-1,2-diolate moiety: design, synthesis, cyclooxygenase inhibition, and nitric oxide release studies.
Bioorganic & medicinal chemistry 2007;15(21):6796-801.
2007: Pierre Morissette; Raymond Hreiche; Louise Mallet; Dean Vo; Edward E Knaus; Jacques Turgeon
Olanzapine prolongs cardiac repolarization by blocking the rapid component of the delayed rectifier potassium current.
Journal of psychopharmacology (Oxford, England) 2007;21(7):735-41.
2007: Carlos Velázquez; PN Praveen Rao; Michael L Citro; Larry K Keefer; Edward E Knaus
O2-acetoxymethyl-protected diazeniumdiolate-based NSAIDs (NONO-NSAIDs): synthesis, nitric oxide release, and biological evaluation studies.
Bioorganic & medicinal chemistry 2007;15(14):4767-74.
2007: Walter A Cristofoli; Leonard I Wiebe; Erik De Clercq; Graciela Andrei; Robert Snoeck; Jan Balzarini; Edward E Knaus
5-alkynyl analogs of arabinouridine and 2'-deoxyuridine: cytostatic activity against herpes simplex virus and varicella-zoster thymidine kinase gene-transfected cells.
Journal of medicinal chemistry 2007;50(12):2851-7.
2007: Afshin Zarghi; PN Praveen Rao; Edward E Knaus
Synthesis and biological evaluation of methanesulfonamide analogues of rofecoxib: Replacement of methanesulfonyl by methanesulfonamido decreases cyclooxygenase-2 selectivity.
Bioorganic & medicinal chemistry 2007;15(2):1056-61.
2007: Afshin Zarghi; Praveen Rao; Edward E Knaus
Design and synthesis of new rofecoxib analogs as selective cyclooxygenase-2 (COX-2) inhibitors: replacement of the methanesulfonyl pharmacophore by a N-acetylsulfonamido bioisostere.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques 2007;10(2):159-67.
2006: Anne Moreau; Qiao-Hong Chen; PN Praveen Rao; Edward E Knaus
Design, synthesis, and biological evaluation of (E)-3-(4-methanesulfonylphenyl)-2-(aryl)acrylic acids as dual inhibitors of cyclooxygenases and lipoxygenases.
Bioorganic & medicinal chemistry 2006;14(23):7716-27.
2006: Qiao-Hong Chen; Praveen Rao; Edward E Knaus
Synthesis and biological evaluation of a novel class of rofecoxib analogues as dual inhibitors of cyclooxygenases (COXs) and lipoxygenases (LOXs).
Bioorganic & medicinal chemistry 2006;14(23):7898-909.
2006: Anne Moreau; Praveen Rao; Edward E Knaus
Synthesis and biological evaluation of acyclic triaryl (Z)-olefins possessing a 3,5-di-tert-butyl-4-hydroxyphenyl pharmacophore: dual inhibitors of cyclooxygenases and lipoxygenases.
Bioorganic & medicinal chemistry 2006;14(15):5340-50.
2006: Praveen Rao; Qiao-Hong Chen; Edward E Knaus
Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: dual inhibitors of cyclooxygenases and lipoxygenases.
Journal of medicinal chemistry 2006;49(5):1668-83.
2005: Qiao-Hong Chen; Praveen Rao; Edward E Knaus
Design, synthesis, and biological evaluation of linear 1-(4-, 3- or 2-methylsulfonylphenyl)-2-phenylacetylenes: a novel class of cyclooxygenase-2 inhibitors.
Bioorganic & medicinal chemistry 2005;13(23):6425-34.
2005: Praveen Rao; Qiao-Hong Chen; Edward E Knaus
Synthesis and biological evaluation of 1,3-diphenylprop-2-yn-1-ones as dual inhibitors of cyclooxygenases and lipoxygenases.
Bioorganic & medicinal chemistry letters 2005;15(21):4842-5.
2005: Sameh Moharram; Aihua Zhou; Piyush Kumar; Edward E Knaus; Leonard I Wiebe
Radiosynthesis, in vitro cellular uptake and in vivo biodistribution of 3'-O-(3-benzenesulfonylfuroxan-4-yl)-5-[125I]iodo-2'-deoxyuridine, a nucleoside-based nitric oxide donor.
Nuclear medicine and biology 2005;32(6):641-5.
2005: Qiao-Hong Chen; Praveen Rao; Edward E Knaus
Design, synthesis, and biological evaluation of N-acetyl-2-(or 3-)carboxymethylbenzenesulfonamides as cyclooxygenase isozyme inhibitors.
Bioorganic & medicinal chemistry 2005;13(15):4694-703.
2005: Bernard Sowa; Gillian Rauw; Asghar Davood; Afshin Fassihi; Edward E Knaus; Glen B Baker
Design and biological evaluation of phenyl-substituted analogs of beta-phenylethylidenehydrazine.
Bioorganic & medicinal chemistry 2005;13(14):4389-95.
2005: Kevin W Morin; Weili Duan; Edward E Knaus; Alexander J B McEwan; Leonard I Wiebe
A human osteosarcoma cell line expressing herpes simplex type-1 thymidine kinase: studies with radiolabeled (E)-5-(2-iodovinyl)-2'-fluoro-2'-deoxyuridine.
Nuclear medicine and biology 2005;32(5):459-64.
2005: Carlos Velázquez; PN Praveen Rao; Edward E Knaus
Novel nonsteroidal antiinflammatory drugs possessing a nitric oxide donor diazen-1-ium-1,2-diolate moiety: design, synthesis, biological evaluation, and nitric oxide release studies.
Journal of medicinal chemistry 2005;48(12):4061-7.
2005: Javid S Mojarrad; Dean Vo; Carlos Velázquez; Edward E Knaus
Design and synthesis of alkyl 7,7-dihalo-3-methyl-5-(nitrophenyl)-2-azabicyclo[4.1.0]hept-3-ene-4-carboxylates with calcium channel antagonist activity.
Bioorganic & medicinal chemistry 2005;13(12):4085-91.
2005: Carlos Velázquez; Praveen Rao; Robert McDonald; Edward E Knaus
Synthesis and biological evaluation of 3,4-diphenyl-1,2,5-oxadiazole-2-oxides and 3,4-diphenyl-1,2,5-oxadiazoles as potential hybrid COX-2 inhibitor/nitric oxide donor agents.
Bioorganic & medicinal chemistry 2005;13(8):2749-57.
2005: Qiao-Hong Chen; Praveen Rao; Edward E Knaus
Design, synthesis, and biological evaluation of N-acetyl-2-carboxybenzenesulfonamides: a novel class of cyclooxygenase-2 (COX-2) inhibitors.
Bioorganic & medicinal chemistry 2005;13(7):2459-68.
2005: Jeffrey-Tri Nguyen; Carlos Velázquez; Edward E Knaus
Hantzsch 1,4-dihydropyridines containing a diazen-1-ium-1,2-diolate nitric oxide donor moiety to study calcium channel antagonist structure-activity relationships and nitric oxide release.
Bioorganic & medicinal chemistry 2005;13(5):1725-38.
2005: Md Jashim Uddin; Praveen Rao; Robert McDonald; Edward E Knaus
Design and synthesis of (E)-1,1,2-triarylethenes: novel inhibitors of the cyclooxygenase-2 (COX-2) isozyme.
Bioorganic & medicinal chemistry letters 2005;15(2):439-42.
2005: Md Jashim Uddin; PN Praveen Rao; Edward E Knaus
Design and synthesis of (Z)-1,2-diphenyl-1-(4-methanesulfonamidophenyl)alk-1-enes and (Z)-1-(4-azidophenyl)-1,2-diphenylalk-1-enes: novel inhibitors of cyclooxygenase-2 (COX-2) with anti-inflammatory and analgesic activity.
Bioorganic & medicinal chemistry 2005;13(2):417-24.
2004: Md Jashim Uddin; PN Praveen Rao; Robert McDonald; Edward E Knaus
A new class of acyclic 2-alkyl-1,1,2-triaryl (Z)-olefins as selective cyclooxygenase-2 inhibitors.
Journal of medicinal chemistry 2004;47(24):6108-11.
2004: Md Jashim Uddin; Praveen Rao; Edward E Knaus
Design and synthesis of acyclic triaryl (Z)-olefins: a novel class of cyclooxygenase-2 (COX-2) inhibitors.
Bioorganic & medicinal chemistry 2004;12(22):5929-40.
2004: Kazue Ohkura; Wei Yan Sun; Koh-ichi Seki; Edward E Knaus; Leonard I Wiebe
(2S)-2-[1-(2,4-Difluoro-5-iodophenyl)-2-deoxy-beta-D-ribofuranos-5-yloxy]-8-methyl-4H-1,3,2-benzodioxaphosphole 2-oxide.
Acta crystallographica. Section C, Crystal structure communications 2004;60(Pt 11):o789-91.
2004: Md Jashim Uddin; Praveen Rao; Md Abdur Rahim; Robert McDonald; Edward E Knaus
A new class of acyclic 2-alkyl-1,2-diaryl (E)-olefins as selective cyclooxygenase-2 (COX-2) inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(19):4911-4.
2004: Kyla M Smith; Amy M L Ng; Sylvia Y M Yao; Kathy A Labedz; Edward E Knaus; Leonard I Wiebe; Carol E Cass; Stephen A Baldwin; Xing-Zhen Chen; Edward Karpinski; James D Young
Electrophysiological characterization of a recombinant human Na+-coupled nucleoside transporter (hCNT1) produced in Xenopus oocytes.
The Journal of physiology 2004;558(Pt 3):807-23.
2004: Praveen Rao; Md Jashim Uddin; Edward E Knaus
Design, synthesis, and structure-activity relationship studies of 3,4,6-triphenylpyran-2-ones as selective cyclooxygenase-2 inhibitors.
Journal of medicinal chemistry 2004;47(16):3972-90.
2004: Carlos Velázquez; Edward E Knaus
Synthesis and biological evaluation of 1,4-dihydropyridine calcium channel modulators having a diazen-1-ium-1,2-diolate nitric oxide donor moiety for the potential treatment of congestive heart failure.
Bioorganic & medicinal chemistry 2004;12(14):3831-40.
2004: Kevin W Morin; Weili Duan; Lihua Xu; Aihua Zhou; Sameh Moharram; Edward E Knaus; Alexander J B McEwan; Leonard I Wiebe
Cytotoxicity and cellular uptake of pyrimidine nucleosides for imaging herpes simplex type-1 thymidine kinase (HSV-1 TK) expression in mammalian cells.
Nuclear medicine and biology 2004;31(5):623-30.
2004: Javid S Mojarrad; Ramin Miri; Edward E Knaus
Design and synthesis of methyl 2-methyl-7,7-dihalo-5-phenyl-2-azabicyclo[4.1.0]hept-3-ene-4-carboxylates with calcium channel antagonist activity.
Bioorganic & medicinal chemistry 2004;12(12):3215-20.
2004: Afshin Zarghi; PN Praveen Rao; Edward E Knaus
Sulfonamido, azidosulfonyl and N-acetylsulfonamido analogues of rofecoxib: 4-[4-(N-acetylsulfonamido)phenyl]-3-(4-methanesulfonylphenyl)-2(5H)furanone is a potent and selective cyclooxygenase-2 inhibitor.
Bioorganic & medicinal chemistry letters 2004;14(8):1957-60.
2004: Md Jashim Uddin; Praveen Rao; Edward E Knaus
Design of acyclic triaryl olefins: a new class of potent and selective cyclooxygenase-2 (COX-2) inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(8):1953-6.
2004: Sameh Moharram; Aihua Zhou; Leonard I Wiebe; Edward E Knaus
Design and synthesis of 3'- and 5'-O-(3-benzenesulfonylfuroxan-4-yl)-2'-deoxyuridines: biological evaluation as hybrid nitric oxide donor-nucleoside anticancer agents.
Journal of medicinal chemistry 2004;47(7):1840-6.
2004: Ashraf S Al-Madhoun; Staffan Eriksson; Zhi-Xian Wang; Ebrahim Naimi; Edward E Knaus; Leonard I Wiebe
Phosphorylation of isocarbostyril- and difluorophenyl-nucleoside thymidine mimics by the human deoxynucleoside kinases.
Nucleosides, nucleotides & nucleic acids 2004;23(12):1865-74.
2004: Rudong Shan; Carlos Velazquez; Edward E Knaus
Syntheses, calcium channel agonist-antagonist modulation activities, and nitric oxide release studies of nitrooxyalkyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-(2,1,3-benzoxadiazol-4-yl)pyridine-5-carboxylate racemates, enantiomers, and diastereomers.
Journal of medicinal chemistry 2004;47(1):254-61.
2003: Wei Yan Sun; Aihua Zhou; Leonard I Wiebe; Edward E Knaus
Cyclosaligenyl pronucleotides of 5-iodo and 5-trifluoromethyl-1-(2-deoxy-beta-D-ribofuranosyl)-2,4-difluorobenzene mimics of thymidine: synthesis and evaluation of this pronucleotide monophosphate delivery system for compounds with potential anticancer activity.
Nucleosides, nucleotides & nucleic acids 2003;22(12):2121-32.
2003: Panteha Khalili; Ebrahim Naimi; Wei Yan Sun; Edward E Knaus; Leonard I Wiebe
Dose-dependent pharmacokinetics of 1-(2-deoxy-beta-D- ribofuranosyl)-2,4-difluoro-5-iodobenzene: a potential mimic of 5-iodo-2'-deoxyuridine.
Biopharmaceutics & drug disposition 2003;24(9):385-95.
2003: Md Jashim Uddin; Praveen Rao; Edward E Knaus
Design and synthesis of novel celecoxib analogues as selective cyclooxygenase-2 (COX-2) inhibitors: replacement of the sulfonamide pharmacophore by a sulfonylazide bioisostere.
Bioorganic & medicinal chemistry 2003;11(23):5273-80.
2003: PN Praveen Rao; Mohsen Amini; Huiying Li; Amgad G Habeeb; Edward E Knaus
Design, synthesis, and biological evaluation of 6-substituted-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors.
Journal of medicinal chemistry 2003;46(23):4872-82.
2003: P Srinath; Praveen Rao; Edward E Knaus; Mavanur R Suresh
Effect of cyclooxygenase-2 (COX-2) inhibitors on prostate cancer cell proliferation.
Anticancer research 2003;23(5A):3923-8.
2003: Praveen Rao; Mohsen Amini; Huiying Li; Amgad G Habeeb; Edward E Knaus
6-Alkyl, alkoxy, or alkylthio-substituted 3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors.
Bioorganic & medicinal chemistry letters 2003;13(13):2205-9.
2003: Panteha Khalili; Ebrahim Naimi; Wei Yan Sun; Edward E Knaus; Leonard I Wiebe
Biochemical and pharmacokinetic evaluation of a novel pyrimidine nucleoside nitric oxide donor as a potential anticancer/antiviral agent.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2003;19(4):305-13.
2003: Ebrahim Naimi; Aihua Zhou; Panteha Khalili; Leonard I Wiebe; Jan Balzarini; Erik De Clercq; Edward E Knaus
Synthesis of 3'- and 5'-nitrooxy pyrimidine nucleoside nitrate esters: "nitric oxide donor" agents for evaluation as anticancer and antiviral agents.
Journal of medicinal chemistry 2003;46(6):995-1004.
2002: M Abdur Rahim; Praveen Rao; Edward E Knaus
Isomeric acetoxy analogues of rofecoxib: a novel class of highly potent and selective cyclooxygenase-2 inhibitors.
Bioorganic & medicinal chemistry letters 2002;12(19):2753-6.
2002: Panteha Khalili; Ebrahim Naimi; Edward E Knaus; Leonard I Wiebe
Pharmacokinetics and metabolism of the novel synthetic C-nucleoside, 1-(2-deoxy-beta-D-ribofuranosyl)-2,4-difluoro-5-iodobenzene: a potential mimic of 5-iodo-2'-deoxyuridine.
Biopharmaceutics & drug disposition 2002;23(3):105-13.
2002: Rudong Shan; Susan E Howlett; Edward E Knaus
Syntheses, calcium channel agonist-antagonist modulation activities, nitric oxide release, and voltage-clamp studies of 2-nitrooxyethyl 1,4-dihydro- 2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl)pyridine-5-carboxylate enantiomers.
Journal of medicinal chemistry 2002;45(4):955-61.
2001: Leonard I Wiebe; Edward E Knaus
Enzyme-targeted, nucleoside-based radiopharmaceuticals for scintigraphic monitoring of gene transfer and expression.
Current pharmaceutical design 2001;7(18):1893-906.
2001: Rakesh Kumar; L Wang; Leonard I Wiebe; Edward E Knaus
Synthesis and biological investigations of 5-substituted pyrimidine nucleosides coupled to a dihydropyridine/pyridinium salt redox chemical delivery system.
Archiv der Pharmazie 2001;334(11):351-6.
2001: Amgad G Habeeb; PN Praveen Rao; Edward E Knaus
Design and synthesis of celecoxib and rofecoxib analogues as selective cyclooxygenase-2 (COX-2) inhibitors: replacement of sulfonamide and methylsulfonyl pharmacophores by an azido bioisostere.
Journal of medicinal chemistry 2001;44(18):3039-42.
2001: Amgad G Habeeb; PN Praveen Rao; Edward E Knaus
Design and synthesis of 4,5-diphenyl-4-isoxazolines: novel inhibitors of cyclooxygenase-2 with analgesic and antiinflammatory activity.
Journal of medicinal chemistry 2001;44(18):2921-7.
2001: Ebrahim Naimi; Weili Duan; Leonard I Wiebe; Edward E Knaus
Synthesis of unnatural 7-substituted-1-(2-deoxy-beta-D-ribofuranosyl)isocarbostyrils: "thymine replacement" analogs of deoxythymidine for evaluation as antiviral and anticancer agents.
Nucleosides, nucleotides & nucleic acids 2001;20(8):1533-53.
2001: B L Mark; Jonathan C Parrish; ZX Wang; Leonard I Wiebe; Edward E Knaus; Michael N G James
(E)-1-(2'-deoxy-beta-D-ribofuranosyl)-2,4-difluoro-5-(2-iodovinyl)benzene.
Acta crystallographica. Section C, Crystal structure communications 2001;57(Pt 6):758-60.
2001: ZX Wang; Weili Duan; Leonard I Wiebe; Jan Balzarini; Erik De Clercq; Edward E Knaus
Synthesis of 1-(2-deoxy-beta-D-ribofuranosyl)-2,4-difluoro-5-substituted-benzenes: "thymine replacement" analogs of thymidine for evaluation as anticancer and antiviral agents.
Nucleosides, nucleotides & nucleic acids 2001;20(1-2):41-58.
2001: ZX Wang; Weili Duan; Leonard I Wiebe; Jan Balzarini; Erik De Clercq; Edward E Knaus
Synthesis of 1-(2-deoxy-beta-D-ribofuranosyl)-2,4-difluoro-5-substituted-benzene thymidine mimics, some related alpha-anomers, and their evaluation as antiviral and anticancer agents.
Nucleosides, nucleotides & nucleic acids 2001;20(1-2):11-40.
2000: ZX Wang; Weili Duan; Leonard I Wiebe; Erik De Clercq; Jan Balzarini; Edward E Knaus
Syntheses of 1-[(2-hydroxyethoxy)methyl]- and 1-[(1,3-dihydroxy-2-propoxy)methyl]- derivatives of 5-substituted-2,4-difluorobenzene: unnatural acyclo thymidine mimics for evaluation as anticancer and antiviral agents.
Nucleosides, nucleotides & nucleic acids 2000;19(9):1397-411.
2000: N Iqbal; C A McEwen; Soroush Sardari; Mohsen Daneshtalab; Edward E Knaus
Evaluation of methylthio-, methylsulfinyl-, and methylsulfonyl-analogs of alkanes and alkanoic acids as cardiac inotropic and antifungal agents.
Archiv der Pharmazie 2000;333(9):293-8.
2000: Kevin W Morin; Edward E Knaus; Leonard I Wiebe; H Xia; Alexander J B McEwan
Reporter gene imaging: effects of ganciclovir treatment on nucleoside uptake, hypoxia and perfusion in a murine gene therapy tumour model that expresses herpes simplex type-1 thymidine kinase.
Nuclear medicine communications 2000;21(2):129-37.
2000: Jonathan C Parrish; Rudong Shan; Edward E Knaus; Michael N G James
Racemic isopropyl 1,4-dihydro-2,6-dimethyl-4-(6-methyl-2-pyridyl)-3- nitropyridine-5-carboxylate hemibenzene solvate.
Acta crystallographica. Section C, Crystal structure communications 2000;56 ( Pt 1)():107-9.
1999: M Ramesh; Wandikayi Matowe; MW Wolowyk; Edward E Knaus
Synthesis and calcium channel antagonist activity of dialkyl 1,4-dihydro-2,6-dimethyl-4-[4-(1-methoxycarbonyl-1,4-dihydropyridyl)]-3 ,5- pyridinedicarboxylates.
Archiv der Pharmazie 1999;332(11):385-8.
1999: SH Yiu; Edward E Knaus
Synthesis, calcium channel antagonist activity, and anticonvulsant activity of 3-ethyl 5-methyl 1,4-dihydro-2-[(2-hydroxyethoxy) methyl]-6-methyl-4-(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate coupled to a 1-methyl-1,4-dihydropyridyl-3-carbonyl chemical delivery system.
Archiv der Pharmazie 1999;332(10):363-7.
1999: Rudong Shan; Edward E Knaus
The design of (-)-(S)-2-nitrooxyethyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl) pyridine-5-carboxylate: a cardioselective positive inotropic derivative of Bay K 8644.
Bioorganic & medicinal chemistry letters 1999;9(17):2613-4.
1999: Z Xia; Leonard I Wiebe; G G Miller; Edward E Knaus
Synthesis and biological evaluation of butanoate, retinoate, and bis(2,2,2-trichloroethyl)phosphate derivatives of 5-fluoro-2'-deoxyuridine and 2',5-difluoro-2'-deoxyuridine as potential dual action anticancer prodrugs.
Archiv der Pharmazie 1999;332(8):286-94.
1999: S A Agudoawu; SH Yiu; J L Wallace; Edward E Knaus
Synthesis and analgesic activity of 2-methyl-2-[1-(3-benzoyl-4-substituted-1,4-dihydropyridyl)]acetic acid methyl esters, acetic acids, and acetamides.
Archiv der Pharmazie 1999;332(6):213-8.
1998: Keykavous Parang; Leonard I Wiebe; Edward E Knaus; J S Huang; D Lorne J Tyrrell
In vitro anti-hepatitis B virus activities of 5"-O-myristoyl analogue derivatives of 3"-fluoro-2",3"-dideoxythymidine (FLT) and 3"-azido-2",3"-dideoxythymidine (AZT).
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques 1998;1(3):108-14.
1998: Keykavous Parang; Leonard I Wiebe; Edward E Knaus
Synthesis, in vitro anti-human immunodeficiency virus structure-activity relationships and biological stability of 5'-O-myristoyl analogue derivatives of 3'-azido-2',3'-dideoxythymidine (AZT) as potential prodrugs.
Antiviral chemistry & chemotherapy 1998;9(4):311-23.
1998: Keykavous Parang; Edward E Knaus; Leonard I Wiebe
Synthesis, in vitro anti-HIV activity, and biological stability of 5'-O-myristoyl analogue derivatives of 3'-fluoro-2',3'-dideoxythymidine (FLT) as potential bifunctional prodrugs of FLT.
Nucleosides & nucleotides 1998;17(6):987-1008.
1998: N Iqbal; M R Akula; Dean Vo; Wandikayi Matowe; C A McEwen; MW Wolowyk; Edward E Knaus
Synthesis, rotamer orientation, and calcium channel modulation activities of alkyl and 2-phenethyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-(3- or 6-substituted-2-pyridyl)-5-pyridinecarboxylates.
Journal of medicinal chemistry 1998;41(11):1827-37.
1998: M Ramesh; Wandikayi Matowe; M R Akula; Dean Vo; L Dagnino; M C Li-Kwong-Ken; MW Wolowyk; Edward E Knaus
Synthesis and calcium channel-modulating effects of alkyl (or cycloalkyl) 1,4-dihydro-2,6-dimethyl-3-nitro-4-pyridyl-5-pyridinecarboxylate racemates and enantiomers.
Journal of medicinal chemistry 1998;41(4):509-14.
1997: R Miri; S E Howlett; Edward E Knaus
Synthesis and calcium channel modulating effects of isopropyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-(thienyl)-5-pyridinecarboxylates.
Archiv der Pharmazie 1997;330(9-10):290-4.
1997: Rakesh Kumar; Leonard I Wiebe; Edward E Knaus
Synthesis and antiviral activity of 5-ethyl-5-halo-6-alkoxy-(or azido)-5,6-dihydro-2'-deoxyuridine diastereomers as potential prodrugs to 5-ethyl-2'-deoxyuridine.
Archiv der Pharmazie 1997;330(8):259-63.
1997: Kevin W Morin; E D Atrazheva; Edward E Knaus; Leonard I Wiebe
Synthesis and cellular uptake of 2'-substituted analogues of (E)-5-(2-[125I]iodovinyl)-2'-deoxyuridine in tumor cells transduced with the herpes simplex type-1 thymidine kinase gene. Evaluation as probes for monitoring gene therapy.
Journal of medicinal chemistry 1997;40(14):2184-90.
1997: Kevin W Morin; Edward E Knaus; Leonard I Wiebe
Non-invasive scintigraphic monitoring of gene expression in a HSV-1 thymidine kinase gene therapy model.
Nuclear medicine communications 1997;18(7):599-605.
1997: R D Anana; H Ng; S E Howlett; Edward E Knaus
Synthesis and smooth muscle calcium channel effects of dialkyl 1,4-dihydro-2,6-dimethyl-4-aryl-3,5-pyridinedicarboxylates containing a nitrone moiety in the 4-aryl substituent.
Archiv der Pharmazie 1997;330(3):53-8.
1997: SH Yiu; Edward E Knaus
Syntheses, calcium channel antagonist and anticonvulsant activities of substituted 1,4-dihydro-3,5-pyridinedicarboxylates containing various 3-alkyl ester substituents.
Archiv der Pharmazie 1997;330(1-2):35-43.
1996: S Yiu; Edward E Knaus
Synthesis, biological evaluation, calcium channel antagonist activity, and anticonvulsant activity of felodipine coupled to a dihydropyridine-pyridinium salt redox chemical delivery system.
Journal of medicinal chemistry 1996;39(23):4576-82.
1996: Keykavous Parang; Edward E Knaus; Leonard I Wiebe; Soroush Sardari; Mohsen Daneshtalab; F Csizmadia
Synthesis and antifungal activities of myristic acid analogs.
Archiv der Pharmazie 1996;329(11):475-82.
1996: R D Anana; Edward E Knaus
Synthesis and smooth muscle calcium channel antagonist effects of alkyl 1,4-dihydro-2,6-dimethyl-4-(pyridinyl)-5-[2-(4,5-dihydro- 4,4-dimethyloxazolin-2-yl)]-3-pyridinecarboxylates.
Archiv der Pharmazie 1996;329(8-9):408-12.
1996: L Wang; Kevin W Morin; R Kumar; M Cheraghali; K G Todd; Glen B Baker; Edward E Knaus; Leonard I Wiebe
In vivo biodistribution, pharmacokinetic parameters, and brain uptake of 5-halo-y-methoxy(or ethoxy)-5,6-dihydro-3'-azido-3'-deoxythymidine diastereomers as potential prodrugs of 3'-azido-3'-deoxythymidine.
Journal of medicinal chemistry 1996;39(4):826-33.
1996: N Iqbal; Edward E Knaus
Synthesis and smooth muscle calcium channel antagonist effects of dialkyl 1,4-dihydro-2,6-dimethyl-4-aryl-3,5-pyridinedicarboxylates containing a nitrooxy or nitrophenyl moiety in the 3-alkyl ester substituent.
Archiv der Pharmazie 1996;329(1):23-6.
1995: Dean Vo; Wandikayi Matowe; M Ramesh; N Iqbal; M W Wolowyk; Susan E Howlett; Edward E Knaus
Syntheses, calcium channel agonist-antagonist modulation activities, and voltage-clamp studies of isopropyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-pyridinylpyridine-5-carboxylate racemates and enantiomers.
Journal of medicinal chemistry 1995;38(15):2851-9.
1995: A M Cheraghali; Kevin W Morin; R Kumar; Edward E Knaus; Leonard I Wiebe
Accumulation of 5-ethyl-2'-deoxyuridine and its 5,6-dihydro prodrugs in murine lung and its potential clinical application.
The Journal of pharmacy and pharmacology 1995;47(7):595-600.
1995: A M Cheraghali; R Kumar; Edward E Knaus; Leonard I Wiebe
Pharmacokinetics and bioavailability of 5-ethyl-2'-deoxyuridine and its novel (5R,6R)-5-bromo-6-ethoxy-5,6-dihydro prodrugs in mice.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(2):223-6.
1994: R Kumar; L Wang; Leonard I Wiebe; Edward E Knaus
Synthesis, in vitro biological stability, and anti-HIV activity of 5-halo-6-alkoxy(or azido)-5,6-dihydro-3'-azido-3'-deoxythymidine diastereomers as potential prodrugs to 3'-azido-3'-deoxythymidine (AZT).
Journal of medicinal chemistry 1994;37(25):4297-306.
1994: A M Cheraghali; Edward E Knaus; Leonard I Wiebe
Bioavailability and pharmacokinetic parameters for 5-ethyl-2'-deoxyuridine.
Antiviral research 1994;25(3-4):259-67.
1994: R Kumar; L Wang; Leonard I Wiebe; Edward E Knaus
Synthesis and antiviral (HIV-1, HBV) activities of 5-halo-6-methoxy(or azido)-5,6-dihydro-3'-fluoro-3'-deoxythymidine diastereomers. Potential prodrugs to 3'-fluoro-3'-deoxythymidine.
Journal of medicinal chemistry 1994;37(21):3554-60.
1994: R Kumar; Edward E Knaus; L F Wiebe; T M Allen
Synthesis of 5-[1-hydroxy (or methoxy)-2,2-dihaloethyl]-2'- deoxyuridines with antiviral and cytotoxic activity.
Antiviral research 1994;24(4):315-25.
1994: A M Cheraghali; Kevin W Morin; R Kumar; Edward E Knaus; Leonard I Wiebe
Synthesis and biodistribution of [4-14C]-5-bromo-6-methoxy-5,6-dihydro-prodrug derivatives of 5-ethyl-2'-deoxyuridine.
Drug design and discovery 1994;12(1):53-61.
1994: A M Cheraghali; R Kumar; L Wang; Edward E Knaus; Leonard I Wiebe
Synthesis, biotransformation, pharmacokinetics, and antiviral properties of 5-ethyl-5-halo-6-methoxy-5,6-dihydro-2'-deoxyuridine diastereomers.
Biochemical pharmacology 1994;47(9):1615-25.
1994: P Kumar; Edward E Knaus
Synthesis and antiinflammatory activity of 5-(1,6-dihydropyridyl)-tetrazol-2-acetic acids, esters and amides.
Drug design and discovery 1994;11(1):15-22.
1994: N Iqbal; Dean Vo; C A McEwen; M W Wolowyk; Edward E Knaus
Enantioselective syntheses and calcium channel modulating effects of (+)- and (-)-3-isopropyl 5-(4-methylphenethyll) 1,4-dihydro-2,6-dimethyl-4-(2-pyridyl)-3,5-pyridinedicarboxylates.
Chirality 1994;6(7):515-20.
1993: Kevin W Morin; Leonard I Wiebe; Edward E Knaus
Synthesis of brain-targeted 1-(2-deoxy-2-fluoro-beta-D-ribofuranosyl)-(E)-5-(2-iodovinyl)uracil coupled to a dihydropyridine <---> pyridinium salt redox chemical-delivery system.
Carbohydrate research 1993;249(1):109-16.
1993: R Kumar; Leonard I Wiebe; Edward E Knaus
Synthesis and antiviral activity of novel 5-(1-azido-2-haloethyl) and 5-(1-azido-, amino-, or methoxyethyl) analogs of 2'-deoxyuridine.
Journal of medicinal chemistry 1993;36(17):2470-4.
1993: Dean Vo; M W Wolowyk; Edward E Knaus
Synthesis and beta-adrenergic antagonist activity of heterocyclic propanolamines.
Drug design and discovery 1993;10(2):89-99.
1993: C Y Fiakpui; Oludotun A Phillips; K S Murthy; Edward E Knaus
Synthesis and anticonvulsant activity of 1,3-dihydro-5-phenyl-2H-pyrido[3,4-e]-1,4-diazepin-2-ones.
Drug design and discovery 1993;10(1):45-55.
1993: C Y Fiakpui; Edward E Knaus
Synthesis and anticonvulsant activity of 1,3-dihydro-5-phenyl-2H-pyrido[3,2-e]-1,4-diazepin-2-ones.
Drug design and discovery 1993;10(3):173-81.
1992: M Ramesh; Wandikayi Matowe; Edward E Knaus; M W Wolowyk
Synthesis and calcium channel antagonist activity of dialkyl 1,4-dihydro-2,6-dimethyl-4-[3-(1-methoxy-carbonyl-4-substituted-1,4- dihydro-pyridyl)]-3,5-pyridinedicarboxylates.
Drug design and discovery 1992;8(4):313-23.
1992: J K Buolamwini; Edward E Knaus
Synthesis and antinociceptive activity of 1-[2-(pyridyl)ethyl] and 1-[2-(dihydropyridyl)ethyl] analogues of fentanyl.
Drug design and discovery 1992;8(4):301-12.
1992: Dean Vo; M W Wolowyk; Edward E Knaus
Synthesis and beta-adrenergic antagonist activity of novel (3-oxazolinyl-1,4-dihydropyridyl) propanolamines.
Drug design and discovery 1992;8(4):265-72.
1992: R Kumar; Leonard I Wiebe; Edward E Knaus; T M Allen; M L Tempest
Synthesis, antiviral and cytotoxic activity of 2'-deoxyuridines, 2'-fluoro-2'-deoxyuridines and 2'-arabinouridines containing 5-(1-hydroxy-2-halo-2-ethoxycarbonylethyl)-, 5-(1-hydroxy-2-iodo-2- carboxyethyl)- and 5-[1-hydroxy (or methoxy)-2-iodoethyl] substituents.
Drug design and discovery 1992;8(3):179-89.
1992: Dean Vo; M W Wolowyk; Edward E Knaus
Synthesis and cardioselective beta-adrenergic antagonist activity of quinolyloxypropanolamines.
Drug design and discovery 1992;9(1):69-78.
1992: M Tandon; S Singh; L Xu; P Kumar; Leonard I Wiebe; Edward E Knaus; Wendy P Gati; M L Tempest
Synthesis and biological activity of 5-(2,2-difluorocyclopropyl)-2'-deoxyuridine deoxyuridine diastereomers.
Drug design and discovery 1992;9(1):79-91.
1991: J K Buolamwini; Edward E Knaus
Synthesis and antinociceptive activity of 2- and 3-methyl derivatives of 4-(pyridyl) isosteres of meperidine.
Drug design and discovery 1991;8(2):145-56.
1991: Dean Vo; M W Wolowyk; Edward E Knaus
Synthesis and beta-adrenergic antagonist activity of novel (3-cyanodihydropyridyl)propanolamines.
Drug design and discovery 1991;8(2):157-64.
1991: P Kumar; Edward E Knaus
Synthesis and anti-inflammatory activity of 5-(1,4-dihydropyridyl)-tetrazol-2-acetic acids, esters and amides.
Drug design and delivery 1991;7(4):287-94.
1991: M Tandon; S Singh; Leonard I Wiebe; Edward E Knaus; Wendy P Gati; M L Tempest
Synthesis of the diastereomers of 5-(2,2-dichlorocyclopropyl)- and 5-(2-chlorocyclopropyl)-2'-deoxyuridine, and the antiviral and cytotoxic activity of these and bromo analogues.
Drug design and delivery 1991;7(4):295-307.
1991: O A Phillips; Edward E Knaus
Synthesis and anticonvulsant activity of 3-(3'-trifluoromethylphenoxy)-pyridines and -dihydropyridines.
Drug design and delivery 1991;7(4):279-86.
1990: M R Akula; Wandikayi Matowe; M W Wolowyk; Edward E Knaus
Synthesis and calcium channel antagonist activity of nifedipine analogues containing 4-pyridyl and 3-arylethyloxycarbonyl substituents.
Drug design and delivery 1990;7(1):11-7.
1990: J K Buolamwini; Edward E Knaus
Synthesis and antinociceptive activity of 4-pyridyl and -dihydropyridyl analogues of meperidine and ketobemidone.
Drug design and delivery 1990;7(1):19-31.
1990: M R Akula; Wandikayi Matowe; M W Wolowyk; Edward E Knaus
Synthesis and calcium channel antagonist activity of 3-arylmethyl 5-isopropyl 1,4-dihydro-2,6-dimethyl-4-(pyridyl)-3,5-pyridinedicarboxylates.
Pharmaceutical research 1990;7(9):919-22.
1990: P Kumar; Edward E Knaus
Synthesis and antiinflammatory activity of 2H-tetrazol-2-acetic acids, esters and amides.
Drug design and delivery 1990;6(3):169-75.
1990: V K Agrawal; S B Tang; M W Wolowyk; Edward E Knaus
Synthesis and activity of 1,4-dihydropyridine analogues of histamine H2-receptor antagonists.
Drug design and delivery 1990;6(2):101-9.
1990: C Y Fiakpui; M N Namchuk; Edward E Knaus
Synthesis and anticonvulsant activity of 3-alkoxycarbonylaminomethylcarbonylamino-4-benzoylpyridines .
Drug design and delivery 1990;6(2):111-21.
1990: C Im; Edward E Knaus; R P Thuynsma; T M Allen
Synthesis and cytotoxic activity of (E)-1-(2-nitrovinyl) and 1-[N-(tert-butylformiminyl)]-substituted 1,4-dihydropyridines and 2-pyridones.
Drug design and delivery 1990;5(3):239-48.
1990: R Kumar; L H Xu; Edward E Knaus; Leonard I Wiebe; D R Tovell; D Lorne J Tyrrell; T M Allen
Synthesis and antiviral and cytotoxic activity of iodohydrin and iodomethoxy derivatives of 5-vinyl-2'-deoxyuridines, 2'-fluoro-2'-deoxyuridine, and uridine.
Journal of medicinal chemistry 1990;33(2):717-23.
1990: Leonard I Wiebe; Edward E Knaus; Wendy P Gati; Takashi Iwashina; L McQueen
Drug-induced perturbations in the in vivo distribution of oncological radiotracers--II. 5-[125I]iodo-2'-deoxyuridine influenced by nitrobenzylthioinosine-5'-phosphate (NBMPR-P) and acyclothymidine (ACT).
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes 1990;41(2):159-62.
1989: M R Akula; Wandikayi Matowe; M W Wolowyk; Edward E Knaus
Synthesis and calcium channel antagonist activity of alkyl cycloalkyl esters of nifedipine containing pyridinyl substituents.
Drug design and delivery 1989;5(2):117-23.
1989: John R Mercer; L H Xu; Edward E Knaus; Leonard I Wiebe
Synthesis and tumor uptake of 5-82Br- and 5-131I-labeled 5-halo-1-(2-fluoro-2-deoxy-beta-D-ribofuranosyl)uracils.
Journal of medicinal chemistry 1989;32(6):1289-94.
1989: R Kumar; Leonard I Wiebe; T W Hall; Edward E Knaus; D R Tovell; D Lorne J Tyrrell; T M Allen; R Fathi-Afshar
Synthesis of 5-[1-hydroxy(or methoxy)-2-bromo(or chloro)ethyl]-2'-deoxyuridines and related halohydrin analogues with antiviral and cytotoxic activity.
Journal of medicinal chemistry 1989;32(5):941-4.
1989: R Kumar; Leonard I Wiebe; Edward E Knaus; T M Allen; R Fathi-Afshar; D R Tovell; D Lorne J Tyrrell
Synthesis, cytotoxic and antiviral activity of uracils containing 5-(1-hydroxy-2-haloethyl)- and 5-(1-methoxy-2-haloethyl) substituents.
Drug design and delivery 1989;4(3):227-35.
1989: O A Phillips; L A Nelson; Edward E Knaus; T M Allen; R Fathi-Afshar
Synthesis and cytotoxic activity of pyridylthio, pyridylsulfinyl, and pyridylsulfonyl methyl acrylates.
Drug design and delivery 1989;4(2):121-7.
1989: Wandikayi Matowe; M Akula; Edward E Knaus; M W Wolowyk
AK-2-38, a nifedipine analogue with potent smooth muscle calcium antagonist action and partial agonist effects on isolated guinea pig left atrium.
Proceedings of the Western Pharmacology Society 1989;32():305-7.
1989: L K Ho; Edward E Knaus; T M Allen; R Fathi-Afshar
Synthesis and cytotoxic activity of tetrahydropyridylidene-2- and -4-sulfonamides.
Drug design and delivery 1989;4(1):35-43.
1988: M Ramesh; Wandikayi Matowe; M W Wolowyk; Edward E Knaus
Synthesis and calcium channel antagonist activity of nifedipine analogues containing 1-oxido-2-pyridyl in place of the 2-nitrophenyl moiety.
Drug design and delivery 1988;3(4):337-41.
1988: V K Agrawal; S B Tang; M W Wolowyk; Edward E Knaus
Synthesis and activity of pyridine analogues of histamine H2-receptor antagonists.
Drug design and delivery 1988;3(4):297-307.
1988: Takashi Iwashina; D R Tovell; L Xu; D Lorne J Tyrrell; Edward E Knaus; Leonard I Wiebe
Synthesis and antiviral activity of IVFRU, a potential probe for the non-invasive diagnosis of herpes simplex encephalitis.
Drug design and delivery 1988;3(4):309-21.
1988: H Wynn; M Ramesh; Wandikayi Matowe; M W Wolowyk; Edward E Knaus
Synthesis and calcium channel antagonist activity of 1,2-dihydropyridyl analogues of nifedipine.
Drug design and delivery 1988;3(3):245-56.
1988: S Stathaki; Leonard I Wiebe; Edward E Knaus; J A Rogers; D Tovell; D Lorne J Tyrrell
Liposomes for targeted delivery of radioiodinated IVdU and 3-CH3-IVdU for non-invasive detection of herpes simplex virus encephalitis in mice.
Drug design and delivery 1988;3(3):223-34.
1988: D R Tovell; J Samuel; John R Mercer; H K Misra; L Xu; Leonard I Wiebe; D Lorne J Tyrrell; Edward E Knaus
The in vitro evaluation of nucleoside analogues as probes for use in the noninvasive diagnosis of herpes simplex encephalitis.
Drug design and delivery 1988;3(3):213-21.
1988: J K Buolamwini; Edward E Knaus
Synthesis and antinociceptive activity of 7-aryloxysulfonyl piperidines.
Drug design and delivery 1988;3(1):35-47.
1988: L K Ho; Edward E Knaus; T M Allen; R Fathi-Afshar
Synthesis and cytotoxic activity of 1-(3-oxoprop-1-enyl)-2-pyridones.
Drug design and delivery 1988;2(3):227-37.
1988: D A Soboleski; M C Li-Kwong-Ken; H Wynn; C R Triggle; M W Wolowyk; Edward E Knaus
Synthesis and calcium channel antagonist activity of nifedipine analogues containing 1,2-dihydropyridyl in place of the 1,4-dihydropyridyl moiety.
Drug design and delivery 1988;2(3):177-89.
1987: P Kumar; Edward E Knaus
Synthesis and antiinflammatory activity of N-substituted-dihydropyridylacetic acids, esters, and amides.
Drug design and delivery 1987;2(2):145-59.
1987: M Ramesh; Wandikayi Matowe; M W Wolowyk; Edward E Knaus
Synthesis and calcium channel antagonist activity of alkyl t-butyl esters of nifedipine analogues containing pyridinyl substituents.
Drug design and delivery 1987;2(2):79-89.
1987: D R Tovell; H P Yacyshyn; H K Misra; Edward E Knaus; Leonard I Wiebe; J Samuel; M J Gill; D Lorne J Tyrrell
Effect of acyclovir on the uptake of 131I-labelled 1-(2'fluoro-2'-deoxy-beta-D-arabinofuranosyl)-5-iodouracil in herpes infected cells.
Journal of medical virology 1987;22(2):183-8.
1987: Wendy P Gati; Leonard I Wiebe; Edward E Knaus; Alan R P Paterson
[125I]iodohydroxynitrobenzylthioinosine: a new high-affinity nucleoside transporter probe.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1987;65(5):467-73.
1987: L Dagnino; M C Li-Kwong-Ken; H Wynn; M W Wolowyk; C R Triggle; Edward E Knaus
Synthesis and calcium channel antagonist activity of dialkyl 4- (dihydropyridinyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylates.
Journal of medicinal chemistry 1987;30(4):640-6.
1987: John R Mercer; Edward E Knaus; Leonard I Wiebe
Synthesis and tumor uptake of 5-halo-1-(2'-fluoro-2'-deoxy-beta-D-ribofuranosyl)[2-14C]uracils.
Journal of medicinal chemistry 1987;30(4):670-5.
1987: M W Wolowyk; M C Li-Kwong-Ken; L Dagnino; H Wynn; Edward E Knaus
Novel dihydropyridine calcium channel antagonists: structural features which extend duration of action.
Proceedings of the Western Pharmacology Society 1987;30():97-100.
1986: L Dagnino; M C Li-Kwong-Ken; M W Wolowyk; H Wynn; C R Triggle; Edward E Knaus
Synthesis and calcium channel antagonist activity of dialkyl 1,4-dihydro-2,6-dimethyl-4-(pyridinyl)-3,5-pyridinedicarboxylates.
Journal of medicinal chemistry 1986;29(12):2524-9.
1986: D N Abrams; Y W Lee; John R Mercer; Edward E Knaus; Leonard I Wiebe
Tumour uptake of radiolabelled pyrimidine bases and pyrimidine nucleosides in animal models. IX. Radiolabelled 1-(2'-fluoro-2'-deoxy-beta-D-ribofuranosyl)uracil and 1-(2'-chloro-2'-deoxy-beta-D-ribofuranosyl)uracil.
The British journal of radiology 1986;59(699):263-70.
1986: J Samuel; M J Gill; Takashi Iwashina; D R Tovell; D Lorne J Tyrrell; Edward E Knaus; Leonard I Wiebe
Pharmacokinetics and metabolism of E-5-(2-[131I]iodovinyl)-2'-deoxyuridine in dogs.
Antimicrobial agents and chemotherapy 1986;29(2):320-4.
1985: Y W Lee; Takashi Iwashina; Wendy P Gati; Edward E Knaus; Leonard I Wiebe
Tumor uptake of radiolabelled pyrimidine bases and pyrimidine nucleosides in animal models--VIII. Synthesis and tissue distribution of N-[2-(hydroxyethoxy) methyl]-5-[3H]methyluracil.
The International journal of applied radiation and isotopes 1985;36(5):395-8.
1985: Leonard I Wiebe; R J Flanagan; F Helus; WH Knapp; Edward E Knaus; W Maier-Borst
Radiolabeled L-fucose for diagnostic oncology: preliminary studies in mice and rats using L-1-14C-fucose.
International journal of nuclear medicine and biology 1985;12(2):111-4.
1984: Y W Lee; John R Mercer; Leonard I Wiebe; Edward E Knaus
Tumor uptake of radiolabelled pyrimidine bases and pyrimidine nucleosides in animal models: VI. 1-(3'-[36Cl]-chloro-, 1-(3'-[82Br]-bromo- and 1-(3'-[123I]-Iodo-3'-deoxy-beta-D-arabinofuranosyl)uracil.
The International journal of applied radiation and isotopes 1984;35(11):1057-61.
1984: Y W Lee; John R Mercer; Edward E Knaus; Leonard I Wiebe
The synthesis of [36Cl]-, [82Br]- and [123I]-labelled 1-(3'-chloro-(bromo and iodo)-3'-deoxy-beta-D-arabinofuranosyl)uracil.
The International journal of applied radiation and isotopes 1984;35(11):1053-6.
1984: Wendy P Gati; H K Misra; Edward E Knaus; Leonard I Wiebe
Structural modifications at the 2'- and 3'-positions of some pyrimidine nucleosides as determinants of their interaction with the mouse erythrocyte nucleoside transporter.
Biochemical pharmacology 1984;33(21):3325-31.
1984: Y W Lee; D N Abrams; Leonard I Wiebe; Edward E Knaus
Tumor uptake of radiolabelled pyrimidine bases and pyrimidine nucleosides in animal models--V. 6-[36Cl]chlorouracil, 6-[82Br]bromouracil and 6-[123I]iodouracil.
International journal of nuclear medicine and biology 1984;11(3-4):262-6.
1983: Wendy P Gati; Edward E Knaus; Leonard I Wiebe
Interaction of 2'-halogeno-2'-deoxyuridines with the human erythrocyte nucleoside transport mechanism.
Molecular pharmacology 1983;23(1):146-52.
1981: D N Abrams; Edward E Knaus; Leonard I Wiebe; F Helus; W Maier-Borst
Tumour uptake of radiolabelled pyrimidine bases and pyrimidine nucleosides in animal models--IV. 2'-123I-iodo-2'-deoxyuridine.
The International journal of applied radiation and isotopes 1981;32(2):105-8.