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Brian Knight

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Hyperlipoproteinemia Type II

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Abdel M Hebbachi; Brian L Knight; David Wiggins; Dilip D Patel; Geoffrey F Gibbons
Peroxisome proliferator-activated receptor alpha deficiency abolishes the response of lipogenic gene expression to re-feeding: restoration of the normal response by activation of liver X receptor alpha.
Brian L Knight; Abdul M Hebbachi; David Hauton; Anna-Marie Brown; David Wiggins; Dilipkumar D Patel; Geoffrey F Gibbons
A role for PPARalpha in the control of SREBP activity and lipid synthesis in the liver.
K K Islam; Brian L Knight; K N Frayn; Dilipkumar D Patel; Geoffrey F Gibbons
Deficiency of PPARalpha disturbs the response of lipogenic flux and of lipogenic and cholesterogenic gene expression to dietary cholesterol in mouse white adipose tissue.

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All Publications

2008: Abdel M Hebbachi; Brian L Knight; David Wiggins; Dilip D Patel; Geoffrey F Gibbons
Peroxisome proliferator-activated receptor alpha deficiency abolishes the response of lipogenic gene expression to re-feeding: restoration of the normal response by activation of liver X receptor alpha.
The Journal of biological chemistry 2008;283(8):4866-76.
2005: Brian L Knight; Abdul M Hebbachi; David Hauton; Anna-Marie Brown; David Wiggins; Dilipkumar D Patel; Geoffrey F Gibbons
A role for PPARalpha in the control of SREBP activity and lipid synthesis in the liver.
The Biochemical journal 2005;389(Pt 2):413-21.
2005: K K Islam; Brian L Knight; K N Frayn; Dilipkumar D Patel; Geoffrey F Gibbons
Deficiency of PPARalpha disturbs the response of lipogenic flux and of lipogenic and cholesterogenic gene expression to dietary cholesterol in mouse white adipose tissue.
Biochimica et biophysica acta 2005;1734(3):259-68.
2004: Brian L Knight
ATP-binding cassette transporter A1: regulation of cholesterol efflux.
Biochemical Society transactions 2004;32(Pt 1):124-7.
2003: Brian L Knight; Dilipkumar D Patel; Sandy M Humphreys; David Wiggins; Geoffrey F Gibbons
Inhibition of cholesterol absorption associated with a PPAR alpha-dependent increase in ABC binding cassette transporter A1 in mice.
Journal of lipid research 2003;44(11):2049-58.
2003: Rossi P Naoumova; Dilipkumar D Patel; Frans O'Neill; Gilbert R Thompson; Brian L Knight
Treatment with atorvastatin alters the ratio of interleukin-12/interleukin-10 gene expression [corrected].
European journal of clinical investigation 2003;33(1):88-91.
2003: Loretto H Puckey; Brian L Knight
Sequence and functional changes in a putative enhancer region upstream of the apolipoprotein(a) gene.
Atherosclerosis 2003;166(1):119-27.
2002: Loretto H Puckey; Brian L Knight
Interaction of oestrogen and peroxisome proliferator-activated receptors with apolipoprotein(a) gene enhancers.
The Biochemical journal 2002;366(Pt 1):157-63.
2002: Mary C Sugden; Karen Bulmer; Geoffrey F Gibbons; Brian L Knight; Mark J Holness
Peroxisome-proliferator-activated receptor-alpha (PPARalpha) deficiency leads to dysregulation of hepatic lipid and carbohydrate metabolism by fatty acids and insulin.
The Biochemical journal 2002;364(Pt 2):361-8.
2002: Geoffrey F Gibbons; Dilip Patel; David Wiggins; Brian L Knight
The functional efficiency of lipogenic and cholesterogenic gene expression in normal mice and in mice lacking the peroxisomal proliferator-activated receptor-alpha (PPAR-alpha).
Advances in enzyme regulation 2002;42():227-47.
2001: J I Trickett; Dilipkumar D Patel; Brian L Knight; E David Saggerson; Geoffrey F Gibbons; Richard J Pease
Characterization of the rodent genes for arylacetamide deacetylase, a putative microsomal lipase, and evidence for transcriptional regulation.
The Journal of biological chemistry 2001;276(43):39522-32.
2001: Loretto H Puckey; Brian L Knight
Variation at position 162 of peroxisome proliferator-activated receptor alpha does not influence the effect of fibrates on cholesterol or triacylglycerol concentrations in hyperlipidaemic subjects.
Pharmacogenetics 2001;11(7):619-24.
2001: Frans O'Neill; Dilipkumar D Patel; Brian L Knight; Clare Neuwirth; M Bourbon; Anne K Soutar; Graham W Taylor; Gilbert R Thompson; Rossi P Naoumova
Determinants of variable response to statin treatment in patients with refractory familial hypercholesterolemia.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(5):832-7.
2001: Dilipkumar D Patel; Brian L Knight; David Wiggins; Sandy M Humphreys; Geoffrey F Gibbons
Disturbances in the normal regulation of SREBP-sensitive genes in PPAR alpha-deficient mice.
Journal of lipid research 2001;42(3):328-37.
2000: Dilipkumar D Patel; Brian L Knight; Anne K Soutar; Geoffrey F Gibbons; DP Wade
The effect of peroxisome-proliferator-activated receptor-alpha on the activity of the cholesterol 7 alpha-hydroxylase gene.
The Biochemical journal 2000;351 Pt 3():747-53.
1999: D Norman; Xi-Ming Sun; M Bourbon; Brian L Knight; Rossi P Naoumova; Anne K Soutar
Characterization of a novel cellular defect in patients with phenotypic homozygous familial hypercholesterolemia.
The Journal of clinical investigation 1999;104(5):619-28.
1999: Brian L Knight
Gene structure of apolipoprotein(a) and the regulation of its expression.
Biochemical Society transactions 1999;27(4):447-52.
1998: Dilipkumar D Patel; N Lelli; Rita Garuti; Salvatore Li Volti; Stefano Bertolini; Brian L Knight; Sebastiano Calandra
Analysis of two duplications of the LDL receptor gene affecting intracellular transport, catabolism, and surface binding of the LDL receptor.
Journal of lipid research 1998;39(7):1466-75.
1998: Xi-Ming Sun; Dilipkumar D Patel; Brian L Knight; Anne K Soutar
Influence of genotype at the low density lipoprotein (LDL) receptor gene locus on the clinical phenotype and response to lipid-lowering drug therapy in heterozygous familial hypercholesterolaemia. The Familial Hypercholesterolaemia Regression Study Group.
Atherosclerosis 1998;136(1):175-85.
1997: DP Wade; Loretto H Puckey; Brian L Knight; Francesco Acquati; Alessandra Mihalich; Roberto Taramelli
Characterization of multiple enhancer regions upstream of the apolipoprotein(a) gene.
The Journal of biological chemistry 1997;272(48):30387-99.
1997: Xi-Ming Sun; Dilipkumar D Patel; Brian L Knight; Anne K Soutar
Comparison of the genetic defect with LDL-receptor activity in cultured cells from patients with a clinical diagnosis of heterozygous familial hypercholesterolemia. The Familial Hypercholesterolaemia Regression Study Group.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(11):3092-101.
1997: Loretto H Puckey; R M Lawn; Brian L Knight
Polymorphisms in the apolipoprotein(a) gene and their relationship to allele size and plasma lipoprotein(a) concentration.
Human molecular genetics 1997;6(7):1099-107.
1997: Dilipkumar D Patel; R A Forder; Anne K Soutar; Brian L Knight
Synthesis and properties of the very-low-density-lipoprotein receptor and a comparison with the low-density-lipoprotein receptor.
The Biochemical journal 1997;324 ( Pt 2)():371-7.
1996: J C Webb; Dilipkumar D Patel; Carol C Shoulders; Brian L Knight; Anne K Soutar
Genetic variation at a splicing branch point in intron 9 of the low density lipoprotein (LDL)-receptor gene: a rare mutation that disrupts mRNA splicing in a patient with familial hypercholesterolaemia and a common polymorphism.
Human molecular genetics 1996;5(9):1325-31.
1996: Xi-Ming Sun; Clare Neuwirth; Dilipkumar D Patel; Brian L Knight; Anne K Soutar
Phenotypic variation and its correlation with mutations in the low density lipoprotein (LDL) receptor gene in familial hypercholesterolemia.
Zeitschrift für Gastroenterologie 1996;34 Suppl 3():12-3.
1996: J C Webb; Xi-Ming Sun; S N McCarthy; Clare Neuwirth; Gilbert R Thompson; Brian L Knight; Anne K Soutar
Characterization of mutations in the low density lipoprotein (LDL)-receptor gene in patients with homozygous familial hypercholesterolemia, and frequency of these mutations in FH patients in the United Kingdom.
Journal of lipid research 1996;37(2):368-81.
1995: Xi-Ming Sun; Clare Neuwirth; D P Wade; Brian L Knight; Anne K Soutar
A mutation (T-45C) in the promoter region of the low-density-lipoprotein (LDL)-receptor gene is associated with a mild clinical phenotype in a patient with heterozygous familial hypercholesterolaemia (FH).
Human molecular genetics 1995;4(11):2125-9.
1995: Dilipkumar D Patel; Anne K Soutar; Brian L Knight
Abnormal structure and co-operative binding of low-density lipoprotein receptors containing the Glu-80-->Lys mutation.
Biochimica et biophysica acta 1995;1255(3):285-92.
1995: Xi-Ming Sun; Dilipkumar D Patel; Deepak Bhatnagar; Brian L Knight; Anne K Soutar
Characterization of a splice-site mutation in the gene for the LDL receptor associated with an unpredictably severe clinical phenotype in English patients with heterozygous FH.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(2):219-27.
1995: Vilmundur Gudnason; D Patel; Xi-Ming Sun; S Humphries; Anne K Soutar; Brian L Knight
Effect of the StuI polymorphism in the LDL receptor gene (Ala 370 to Thr) on lipid levels in healthy individuals.
Clinical genetics 1995;47(2):68-74.
1995: B R Zysow; G E Lindahl; D P Wade; Brian L Knight; RM Lawn
C/T polymorphism in the 5' untranslated region of the apolipoprotein(a) gene introduces an upstream ATG and reduces in vitro translation.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(1):58-64.
1994: Stefano Bertolini; Dilipkumar D Patel; D A Coviello; N Lelli; M Ghisellini; Roberta Tiozzo; P Masturzo; N Elicio; Brian L Knight; Sebastiano Calandra
Partial duplication of the EGF precursor homology domain of the LDL-receptor protein causing familial hypercholesterolemia (FH-Salerno).
Journal of lipid research 1994;35(8):1422-30.
1994: Y F Perombelon; Anne K Soutar; Brian L Knight
Variation in lipoprotein(a) concentration associated with different apolipoprotein(a) alleles.
The Journal of clinical investigation 1994;93(4):1481-92.
1994: J C Webb; Dilipkumar D Patel; M D Jones; Brian L Knight; Anne K Soutar
Characterization and tissue-specific expression of the human 'very low density lipoprotein (VLDL) receptor' mRNA.
Human molecular genetics 1994;3(4):531-7.
1994: Brian L Knight
Lp(a) catabolism in hypercholesterolaemic individuals.
Chemistry and physics of lipids 1994;67-68():233-9.
1994: Xi-Ming Sun; Dilipkumar D Patel; J C Webb; Brian L Knight; L M Fan; H J Cai; Anne K Soutar
Familial hypercholesterolemia in China. Identification of mutations in the LDL-receptor gene that result in a receptor-negative phenotype.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(1):85-94.
1993: MD Feher; J C Webb; Dilipkumar D Patel; Ariel F Lant; P D Mayne; Brian L Knight; Anne K Soutar
Cholesterol-lowering drug therapy in a patient with receptor-negative homozygous familial hypercholesterolaemia.
Atherosclerosis 1993;103(2):171-80.
1993: Dilipkumar D Patel; Anne K Soutar; Brian L Knight
A mutation and an antibody that affect chemical cross-linking of low-density lipoprotein receptors on human fibroblasts.
The Biochemical journal 1993;289 ( Pt 2)():569-73.
1992: Xi-Ming Sun; J C Webb; Vilmundur Gudnason; S Humphries; Mary Seed; Gilbert R Thompson; Brian L Knight; Anne K Soutar
Characterization of deletions in the LDL receptor gene in patients with familial hypercholesterolemia in the United Kingdom.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1992;12(7):762-70.
1992: J C Webb; Xi-Ming Sun; Dilipkumar D Patel; S N McCarthy; Brian L Knight; Anne K Soutar
Characterization of two new point mutations in the low density lipoprotein receptor genes of an English patient with homozygous familial hypercholesterolemia.
Journal of lipid research 1992;33(5):689-98.
1992: Y F Perombelon; J J Gallagher; N B Myant; Anne K Soutar; Brian L Knight
Lipoprotein(a) in subjects with familial defective apolipoprotein B100.
Atherosclerosis 1992;92(2-3):203-12.
1991: D P Wade; Brian L Knight; K Harders-Spengel; Anne K Soutar
Detection and quantitation of apolipoprotein(a) mRNA in human liver and its relationship with plasma lipoprotein(a) concentration.
Atherosclerosis 1991;91(1-2):63-72.
1991: Anne K Soutar; S N McCarthy; Mary Seed; Brian L Knight
Relationship between apolipoprotein(a) phenotype, lipoprotein(a) concentration in plasma, and low density lipoprotein receptor function in a large kindred with familial hypercholesterolemia due to the pro664----leu mutation in the LDL receptor gene.
The Journal of clinical investigation 1991;88(2):483-92.
1991: N B Myant; J J Gallagher; Brian L Knight; S N McCarthy; J Frostegård; J Nilsson; A Hamsten; Philippa J Talmud; S E Humphries
Clinical signs of familial hypercholesterolemia in patients with familial defective apolipoprotein B-100 and normal low density lipoprotein receptor function.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1991;11(3):691-703.
1991: Brian L Knight; Y F Perombelon; Anne K Soutar; D P Wade; Mary Seed
Catabolism of lipoprotein(a) in familial hypercholesterolaemic subjects.
Atherosclerosis 1991;87(2-3):227-37.
1990: Anne K Soutar; Brian L Knight
Structure and regulation of the LDL-receptor and its gene.
British medical bulletin 1990;46(4):891-916.
1989: Anne K Soutar; Brian L Knight; Dilipkumar D Patel
Identification of a point mutation in growth factor repeat C of the low density lipoprotein-receptor gene in a patient with homozygous familial hypercholesterolemia that affects ligand binding and intracellular movement of receptors.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(11):4166-70.
1989: D P Wade; Brian L Knight; Anne K Soutar
Regulation of low-density-lipoprotein-receptor mRNA by insulin in human hepatoma Hep G2 cells.
European journal of biochemistry / FEBS 1989;181(3):727-31.
1989: Brian L Knight; S J Gavigan; Anne K Soutar; Dilipkumar D Patel
Defective processing and binding of low-density lipoprotein receptors in fibroblasts from a familial hypercholesterolaemic subject.
European journal of biochemistry / FEBS 1989;179(3):693-8.
1988: Brian L Knight; Dilipkumar D Patel; S J Gavigan; Anne K Soutar
Low-density-lipoprotein-receptor mRNA content of fibroblasts from normal and familial hypercholesterolaemic subjects.
European journal of biochemistry / FEBS 1988;178(2):555-61.
1988: D P Wade; Brian L Knight; Anne K Soutar
Hormonal regulation of low-density lipoprotein (LDL) receptor activity in human hepatoma Hep G2 cells. Insulin increases LDL receptor activity and diminishes its suppression by exogenous LDL.
European journal of biochemistry / FEBS 1988;174(1):213-8.
1988: S J Gavigan; Dilipkumar D Patel; Anne K Soutar; Brian L Knight
An antibody to the low-density lipoprotein (LDL) receptor that partially inhibits the binding of LDL to cultured human fibroblasts.
European journal of biochemistry / FEBS 1988;171(1-2):355-61.
1986: Anne K Soutar; K Harders-Spengel; D P Wade; Brian L Knight
Detection and quantitation of low density lipoprotein (LDL) receptors in human liver by ligand blotting, immunoblotting, and radioimmunoassay. LDL receptor protein content is correlated with plasma LDL cholesterol concentration.
The Journal of biological chemistry 1986;261(36):17127-33.
1986: D P Wade; Brian L Knight; Anne K Soutar
Binding of low-density lipoprotein and chylomicron remnants to the hepatic low-density lipoprotein receptor of dogs, rats and rabbits demonstrated by ligand blotting. Failure to detect a distinct chylomicron-remnant-binding protein by ligand blotting.
European journal of biochemistry / FEBS 1986;159(2):333-40.
1985: D P Wade; Brian L Knight; Anne K Soutar
Detection of the low-density-lipoprotein receptor with biotin-low-density lipoprotein. A rapid new method for ligand blotting.
The Biochemical journal 1985;229(3):785-90.
1983: S J Gavigan; Brian L Knight
The effects of low-density lipoprotein and cholesterol on acyl-coenzyme A: cholesterol acyltransferase activity in membranes from cultured human fibroblasts.
The Biochemical journal 1983;216(1):93-100.
1982: Anne K Soutar; Brian L Knight; N B Myant
The characterization of lipoproteins in the high density fraction obtained from patients with familial lecithin:cholesterol acyltransferase deficiency and their interaction with cultured human fibroblasts.
Journal of lipid research 1982;23(3):380-90.
1981: S J Gavigan; Brian L Knight
Catabolism of low-density lipoprotein by fibroblasts cultured in medium supplemented with saturated or unsaturated free fatty acids.
Biochimica et biophysica acta 1981;665(3):632-5.