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Mikael Knip

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
124
Ilonen, Jorma
91
Akerblom, Hans
75
Simell, Olli
48
Veijola, Riitta
44
Kulmala, Petri
43
Hyöty, Heikki
36
Virtanen, Suvi
32
Savola, Kaisa
29
Vähäsalo, Paula
27
Reijonen, Helena
20
Tapanainen, Päivi
19
Korhonen, Sari
18
Kupila, Antti
18
Simell, Tuula
17
Isojärvi, Jouko

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Publications

TOP 3
Virta M; Pessi T; Helminen M; Seiskari T; Kondrashova A; Knip M; Hyöty H; Hurme M
Interaction between CD14-159C>T polymorphism and Helicobacter pylori is associated with serum total immunoglobulin E.
Uusitalo Liisa; Uusitalo Ulla; Ovaskainen Marja-Leena; Niinistö Sari; Kronberg-Kippilä Carina; Marjamäki Liisa; Ahonen Suvi; Kenward Mike G; Knip Mikael; Veijola Riitta; Virtanen Suvi M
Sociodemographic and lifestyle characteristics are associated with antioxidant intake and the consumption of their dietary sources during pregnancy.
Honkanen Jarno; Skarsvik Susanne; Knip Mikael; Vaarala Outi
Poor in vitro induction of FOXP3 and ICOS in type 1 cytokine environment activated T-cells from children with type 1 diabetes.

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All Publications

2008: Virta M; Pessi T; Helminen M; Seiskari T; Kondrashova A; Knip M; Hyöty H; Hurme M
Interaction between CD14-159C>T polymorphism and Helicobacter pylori is associated with serum total immunoglobulin E.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2008;38(12):1929-34.
2008: Uusitalo Liisa; Uusitalo Ulla; Ovaskainen Marja-Leena; Niinistö Sari; Kronberg-Kippilä Carina; Marjamäki Liisa; Ahonen Suvi; Kenward Mike G; Knip Mikael; Veijola Riitta; Virtanen Suvi M
Sociodemographic and lifestyle characteristics are associated with antioxidant intake and the consumption of their dietary sources during pregnancy.
Public health nutrition 2008;11(12):1379-88.
2008: Honkanen Jarno; Skarsvik Susanne; Knip Mikael; Vaarala Outi
Poor in vitro induction of FOXP3 and ICOS in type 1 cytokine environment activated T-cells from children with type 1 diabetes.
Diabetes/metabolism research and reviews 2008;24(8):635-41.
2008: Näntö-Salonen Kirsti; Kupila Antti; Simell Satu; Siljander Heli; Salonsaari Tiina; Hekkala Anne; Korhonen Sari; Erkkola Risto; Sipilä Jukka I; Haavisto Lotta; Siltala Marja; Tuominen Juhani; Hakalax Jari; Hyöty Heikki; Ilonen Jorma; Veijola Riitta; Simell Tuula; Knip Mikael; Simell Olli
Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial.
Lancet 2008;372(9651):1746-55.
2008: Oikarinen M; Tauriainen S; Honkanen T; Vuori K; Karhunen P; Vasama-Nolvi C; Oikarinen S; Verbeke C; Blair G E; Rantala I; Ilonen J; Simell O; Knip M; Hyöty H
Analysis of pancreas tissue in a child positive for islet cell antibodies.
Diabetologia 2008;51(10):1796-802.
2008: Luopajärvi Kristiina; Savilahti Erkki; Virtanen Suvi M; Ilonen Jorma; Knip Mikael; Akerblom Hans K; Vaarala Outi
Enhanced levels of cow's milk antibodies in infancy in children who develop type 1 diabetes later in childhood.
Pediatric diabetes 2008;9(5):434-41.
2008: Marttila Jane; Huttunen Suvi; Vaarala Outi; Suzuki Kunimasa; Elliott John F; Närvänen Ale; Knip Mikael; Simell Olli; Ilonen Jorma
T-cell reactivity to insulin peptide A1-12 in children with recently diagnosed type 1 diabetes or multiple beta-cell autoantibodies.
Journal of autoimmunity 2008;31(2):142-8.
2008: Uusitalo Liisa; Kenward Mike G; Virtanen Suvi M; Uusitalo Ulla; Nevalainen Jaakko; Niinistö Sari; Kronberg-Kippilä Carina; Ovaskainen Marja-Leena; Marjamäki Liisa; Simell Olli; Ilonen Jorma; Veijola Riitta; Knip Mikael
Intake of antioxidant vitamins and trace elements during pregnancy and risk of advanced beta cell autoimmunity in the child.
The American journal of clinical nutrition 2008;88(2):458-64.
2008: Aarnisalo Johanna; Treszl Andras; Svec Peter; Marttila Jane; Oling Viveka; Simell Olli; Knip Mikael; Körner Anna; Madacsy Laszlo; Vasarhelyi Barna; Ilonen Jorma; Hermann Robert
Reduced CD4+T cell activation in children with type 1 diabetes carrying the PTPN22/Lyp 620Trp variant.
Journal of autoimmunity 2008;31(1):13-21.
2008: Knip Mikael; Siljander Heli
Autoimmune mechanisms in type 1 diabetes.
Autoimmunity reviews 2008;7(7):550-7.
2008: Mäkinen Anna; Härkönen Taina; Ilonen Jorma; Knip Mikael;
Characterization of the humoral immune response to islet antigen 2 in children with newly diagnosed type 1 diabetes.
European journal of endocrinology / European Federation of Endocrine Societies 2008;159(1):19-26.
2008: Pörksen Sven; Nielsen Lotte B; Mortensen Henrik B; Danne Thomas; Kocova Mirjana; Castaño Luis; Pociot Flemming; Hougaard Philip; Ekstrøm Claus T; Gammeltoft Steen; Knip Mikael; Hansen Lars;
Variation within the PPARG gene is associated with residual beta-cell function and glycemic control in children and adolescents during the first year of clinical type 1 diabetes.
Pediatric diabetes 2008;9(4 Pt 1):297-302.
2008: Tauriainen Sisko; Oikarinen Sami; Taimen Kirsi; Laranne Jussi; Sipilä Markku; Lönnrot Maria; Ilonen Jorma; Simell Olli; Knip Mikael; Hyöty Heikki
Temporal relationship between human parechovirus 1 infection and otitis media in young children.
The Journal of infectious diseases 2008;198(1):35-40.
2008: Knip Mikael; Reunanen Antti; Virtanen Suvi M; Nuutinen Matti; Viikari Jorma; Akerblom Hans K
Does the secular increase in body mass in children contribute to the increasing incidence of type 1 diabetes?
Pediatric diabetes 2008;9(3 Pt 2):46-9.
2008: Uusitalo L; Nevalainen J; Niinistö S; Alfthan G; Sundvall J; Korhonen T; Kenward M G; Oja H; Veijola R; Simell O; Ilonen J; Knip M; Virtanen S M
Serum alpha- and gamma-tocopherol concentrations and risk of advanced beta cell autoimmunity in children with HLA-conferred susceptibility to type 1 diabetes mellitus.
Diabetologia 2008;51(5):773-80.
2008: Aarnisalo J; Veijola R; Vainionpää R; Simell O; Knip M; Ilonen J
Cytomegalovirus infection in early infancy: risk of induction and progression of autoimmunity associated with type 1 diabetes.
Diabetologia 2008;51(5):769-72.
2008: Aberg L; Talling M; Härkönen T; Lönnqvist T; Knip M; Alen R; Rantala H; Tyynelä J
Intermittent prednisolone and autoantibodies to GAD65 in juvenile neuronal ceroid lipofuscinosis.
Neurology 2008;70(14):1218-20.
2008: Knip Mikael
Should we screen for risk of type 1 diabetes?
Diabetes care 2008;31(3):622-3.
2008: Kondrashova Anita; Viskari Hanna; Haapala Anna-Maija; Seiskari Tapio; Kulmala Petri; Ilonen Jorma; Knip Mikael; Hyöty Heikki
Serological evidence of thyroid autoimmunity among schoolchildren in two different socioeconomic environments.
The Journal of clinical endocrinology and metabolism 2008;93(3):729-34.
2008: Arkkola Tuula; Uusitalo Ulla; Kronberg-Kippilä Carina; Männistö Satu; Virtanen Mikko; Kenward Michael G; Veijola Riitta; Knip Mikael; Ovaskainen Marja-Leena; Virtanen Suvi M
Seven distinct dietary patterns identified among pregnant Finnish women--associations with nutrient intake and sociodemographic factors.
Public health nutrition 2008;11(2):176-82.
2008: Kondrashova Anita; Mustalahti Kirsi; Kaukinen Katri; Viskari Hanna; Volodicheva Vera; Haapala Anna-Maija; Ilonen Jorma; Knip Mikael; Mäki Markku; Hyöty Heikki;
Lower economic status and inferior hygienic environment may protect against celiac disease.
Annals of medicine 2008;40(3):223-31.
2007: Ankelo M; Kleimola V; Simell S; Simell O; Knip M; Jokisalo E; Tarkia M; Westerlund A; He Q; Viander M; Ilonen J; Hinkkanen A E
Antibody responses to deamidated gliadin peptide show high specificity and parallel antibodies to tissue transglutaminase in developing coeliac disease.
Clinical and experimental immunology 2007;150(2):285-93.
2007: Siljander H T; Veijola R; Reunanen A; Virtanen S M; Akerblom H K; Knip M
Prediction of type 1 diabetes among siblings of affected children and in the general population.
Diabetologia 2007;50(11):2272-5.
2007: Kiviniemi Minna; Hermann Robert; Nurmi Jussi; Ziegler Anette G; Knip Mikael; Simell Olli; Veijola Riitta; Lövgren Timo; Ilonen Jorma;
A high-throughput population screening system for the estimation of genetic risk for type 1 diabetes: an application for the TEDDY (the Environmental Determinants of Diabetes in the Young) study.
Diabetes technology & therapeutics 2007;9(5):460-72.
2007: Simell Satu; Hoppu Sanna; Hekkala Anne; Simell Tuula; Ståhlberg Marja-Riitta; Viander Markku; Yrjänäinen Heta; Grönlund Juhani; Markula Perttu; Simell Ville; Knip Mikael; Ilonen Jorma; Hyöty Heikki; Simell Olli
Fate of five celiac disease-associated antibodies during normal diet in genetically at-risk children observed from birth in a natural history study.
The American journal of gastroenterology 2007;102(9):2026-35.
2007: Oling Viveka; Marttila Jane; Knip Mikael; Simell Olli; Ilonen Jorma
Circulating CD4+CD25 high regulatory T cells and natural killer T cells in children with newly diagnosed type 1 diabetes or with diabetes-associated autoantibodies.
Annals of the New York Academy of Sciences 2007;1107():363-72.
2007: Kordonouri Olga; Maguire Ann M; Knip Mikael; Schober Edith; Lorini Renata; Holl Reinhard W; Donaghue Kim C;
ISPAD Clinical Practice Consensus Guidelines 2006-2007. Other complications and associated conditions.
Pediatric diabetes 2007;8(3):171-6.
2007: Sadeharju Karita; Knip Mikael; Virtanen Suvi M; Savilahti Erkki; Tauriainen Sisko; Koskela Pentti; Akerblom Hans K; Hyöty Heikki;
Maternal antibodies in breast milk protect the child from enterovirus infections.
Pediatrics 2007;119(5):941-6.
2007: Vainionpää Aki; Korpelainen Raija; Kaikkonen Hannu; Knip Mikael; Leppäluoto Juhani; Jämsä Timo
Effect of impact exercise on physical performance and cardiovascular risk factors.
Medicine and science in sports and exercise 2007;39(5):756-63.
2007: Westerlund A; Ankelo M; Simell S; Ilonen J; Knip M; Simell O; Hinkkanen A E
Affinity maturation of immunoglobulin A anti-tissue transglutaminase autoantibodies during development of coeliac disease.
Clinical and experimental immunology 2007;148(2):230-40.
2007: Hekkala Anne; Knip Mikael; Veijola Riitta
Ketoacidosis at diagnosis of type 1 diabetes in children in northern Finland: temporal changes over 20 years.
Diabetes care 2007;30(4):861-6.
2007: Tauriainen Sisko; Martiskainen Mika; Oikarinen Sami; Lönnrot Maria; Viskari Hanna; Ilonen Jorma; Simell Olli; Knip Mikael; Hyöty Heikki
Human parechovirus 1 infections in young children--no association with type 1 diabetes.
Journal of medical virology 2007;79(4):457-62.
2007: Seiskari T; Kondrashova A; Viskari H; Kaila M; Haapala A-M; Aittoniemi J; Virta M; Hurme M; Uibo R; Knip M; Hyöty H;
Allergic sensitization and microbial load--a comparison between Finland and Russian Karelia.
Clinical and experimental immunology 2007;148(1):47-52.
2007: Ankelo Matti; Westerlund Annette; Blomberg Kaj; Knip Mikael; Ilonen Jorma; Hinkkanen Ari E
Time-resolved immunofluorometric dual-label assay for simultaneous detection of autoantibodies to GAD65 and IA-2 in children with type 1 diabetes.
Clinical chemistry 2007;53(3):472-9.
2007: Rinta-Valkama Johanna; Aaltonen Petri; Lassila Markus; Palmén Tuula; Tossavainen Päivi; Knip Mikael; Holthöfer Harry
Densin and filtrin in the pancreas and in the kidney, targets for humoral autoimmunity in patients with type 1 diabetes.
Diabetes/metabolism research and reviews 2007;23(2):119-26.
2007: Kondrashova Anita; Viskari Hanna; Kulmala Petri; Romanov Anatolij; Ilonen Jorma; Hyöty Heikki; Knip Mikael
Signs of beta-cell autoimmunity in nondiabetic schoolchildren: a comparison between Russian Karelia with a low incidence of type 1 diabetes and Finland with a high incidence rate.
Diabetes care 2007;30(1):95-100.
2007: Aaltonen Petri; Rinta-Valkama Johanna; Pätäri Anu; Tossavainen Päivi; Palmén Tuula; Kulmala Petri; Knip Mikael; Holthöfer Harry
Circulating antibodies to nephrin in patients with type 1 diabetes.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2007;22(1):146-53.
2007: Knip Mikael; Hyöty Heikki
[Not Available]
Duodecim; lääketieteellinen aikakauskirja 2007;123(11):1251-3.
2007: Laine Antti-Pekka; Holmberg Hanna; Nilsson Anita; Ortqvist Eva; Kiviniemi Minna; Vaarala Outi; Akerblom Hans K; Simell Olli; Knip Mikael; Ludvigsson Johnny; Ivarsson Sten-A; Larsson Karin; Lernmark Ake; Ilonen Jorma;
Two insulin gene single nucleotide polymorphisms associated with type 1 diabetes risk in the Finnish and Swedish populations.
Disease markers 2007;23(3):139-45.
2006: Tiittanen Minna; Huupponen Johanna T; Knip Mikael; Vaarala Outi
Insulin treatment in patients with type 1 diabetes induces upregulation of regulatory T-cell markers in peripheral blood mononuclear cells stimulated with insulin in vitro.
Diabetes 2006;55(12):3446-54.
2006: Arkkola Tuula; Uusitalo Ulla; Pietikäinen Minna; Metsälä Johanna; Kronberg-Kippilä Carina; Erkkola Maijaliisa; Veijola Riitta; Knip Mikael; Virtanen Suvi M; Ovaskainen Marja-Leena
Dietary intake and use of dietary supplements in relation to demographic variables among pregnant Finnish women.
The British journal of nutrition 2006;96(5):913-20.
2006: Simonen Paula; Korhonen Tapio; Simell Tuula; Keskinen Päivi; Kärkkäinen Maarit; Knip Mikael; Ilonen Jorma; Simell Olli
Parental reactions to information about increased genetic risk of type 1 diabetes mellitus in infants.
Archives of pediatrics & adolescent medicine 2006;160(11):1131-6.
2006: Tiittanen Minna; Paronen Johanna; Savilahti Erkki; Virtanen Suvi M; Ilonen Jorma; Knip Mikael; Akerblom Hans K; Vaarala Outi;
Dietary insulin as an immunogen and tolerogen.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2006;17(7):538-43.
2006: Räsänen M; Kronberg-Kippilä C; Ahonen S; Uusitalo L; Kautiainen S; Erkkola M; Veijola R; Knip M; Kaila M; Virtanen S M
Intake of vitamin D by Finnish children aged 3 months to 3 years in relation to sociodemographic factors.
European journal of clinical nutrition 2006;60(11):1317-22.
2006: Vuorinen Pauli; Rulli Maris; Kuusisto Ari; Simell Satu; Simell Tuula; Vahlberg Tero; Ilonen Jorma; Hyöty Heikki; Knip Mikael; Simell Olli
Time-resolved fluorescence imaging of islet cell autoantibodies.
Annals of the New York Academy of Sciences 2006;1079():226-8.
2006: Ronkainen Matti S; Hoppu Sanna; Korhonen Sari; Simell Satu; Veijola Riitta; Ilonen Jorma; Simell Olli; Knip Mikael
Early epitope- and isotype-specific humoral immune responses to GAD65 in young children with genetic susceptibility to type 1 diabetes.
European journal of endocrinology / European Federation of Endocrine Societies 2006;155(4):633-42.
2006: Gombos Zsofia; Wachowicz Joanna; Veijola Riitta; Akerblom Hans K; Simell Olli; Knip Mikael; Ilonen Jorma; Hermann Robert
Human leukocyte antigen non-class II determinants for type 1 diabetes in the Finnish population.
Human immunology 2006;67(9):714-21.
2006: Pylvänen Virpi; Pakarinen Arto; Knip Mikael; Isojärvi Jouko
Characterization of insulin secretion in Valproate-treated patients with epilepsy.
Epilepsia 2006;47(9):1460-4.
2006: Mäkelä M; Oling V; Marttila J; Waris M; Knip M; Simell O; Ilonen J
Rotavirus-specific T cell responses and cytokine mRNA expression in children with diabetes-associated autoantibodies and type 1 diabetes.
Clinical and experimental immunology 2006;145(2):261-70.
2006: Mäkelä Miia; Vaarala Outi; Hermann Robert; Salminen Kimmo; Vahlberg Tero; Veijola Riitta; Hyöty Heikki; Knip Mikael; Simell Olli; Ilonen Jorma
Enteral virus infections in early childhood and an enhanced type 1 diabetes-associated antibody response to dietary insulin.
Journal of autoimmunity 2006;27(1):54-61.
2006: Vähätalo Liisa; Bärlund Sonja; Hannila Marja-Leena; Uusitalo Ulla; Pigg Hanna-Mari; Salonen Marja; Nucci Anita; Krischer Jeffrey P; Knip Mikael; Akerblom Hans K; Virtanen Suvi M
Relative validity of a dietary interview for assessing infant diet and compliance in a dietary intervention trial.
Maternal & child nutrition 2006;2(3):181-7.
2006: Virtanen S M; Kenward M G; Erkkola M; Kautiainen S; Kronberg-Kippilä C; Hakulinen T; Ahonen S; Uusitalo L; Niinistö S; Veijola R; Simell O; Ilonen J; Knip M
Age at introduction of new foods and advanced beta cell autoimmunity in young children with HLA-conferred susceptibility to type 1 diabetes.
Diabetologia 2006;49(7):1512-21.
2006: Viskari Hanna; Kondrashova Anita; Koskela Pentti; Knip Mikael; Hyöty Heikki
Circulating vitamin D concentrations in two neighboring populations with markedly different incidence of type 1 diabetes.
Diabetes care 2006;29(6):1458-9.
2006: Hermann R; Lipponen K; Kiviniemi M; Kakko T; Veijola R; Simell O; Knip M; Ilonen J
Lymphoid tyrosine phosphatase (LYP/PTPN22) Arg620Trp variant regulates insulin autoimmunity and progression to type 1 diabetes.
Diabetologia 2006;49(6):1198-208.
2006: Pylvänen Virpi; Pakarinen Arto; Knip Mikael; Isojärvi Jouko
Insulin-related metabolic changes during treatment with valproate in patients with epilepsy.
Epilepsy & behavior : E&B 2006;8(3):643-8.
2006: Toivonen Anna M; Kimpimäki Teija; Kupila Antti; Korhonen Sari; Hyöty Heikki; Virtanen Suvi M; Ilonen Jorma; Simell Olli; Knip Mikael
Soluble adhesion molecules in young children with signs of beta-cell autoimmunity--prospective follow-up from birth.
Diabetes/metabolism research and reviews 2006;22(3):176-83.
2006: Hoppu S; Härkönen T; Ronkainen M S; Simell S; Hekkala A; Toivonen A; Ilonen J; Simell O; Knip M
IA-2 antibody isotypes and epitope specificity during the prediabetic process in children with HLA-conferred susceptibility to type I diabetes.
Clinical and experimental immunology 2006;144(1):59-66.
2006: Mrena Samy; Virtanen Suvi M; Laippala Pekka; Kulmala Petri; Hannila Marja-Leena; Akerblom Hans K; Knip Mikael
Models for predicting type 1 diabetes in siblings of affected children.
Diabetes care 2006;29(3):662-7.
2006: Järvelä Ilkka Y; Juutinen Jaana; Koskela Pentti; Hartikainen Anna-Liisa; Kulmala Petri; Knip Mikael; Tapanainen Juha S
Gestational diabetes identifies women at risk for permanent type 1 and type 2 diabetes in fertile age: predictive role of autoantibodies.
Diabetes care 2006;29(3):607-12.
2006: Laine A-P; Turpeinen H; Veijola R; Hermann R; Simell O; Knip M; Ilonen J
Evidence for linkage to and association with type 1 diabetes at the 3q21 region in the Finnish population.
Genes and immunity 2006;7(1):69-72.
2006: Kukko Marika; Toivonen Anna; Kupila Antti; Korhonen Sari; Keskinen Päivi; Veijola Riitta; Virtanen Suvi M; Ilonen Jorma; Simell Olli; Knip Mikael
Familial clustering of beta-cell autoimmunity in initially non-diabetic children.
Diabetes/metabolism research and reviews 2006;22(1):53-8.
2006: Karvonen Seija-Liisa; Knip Mikael
[Not Available]
Duodecim; lääketieteellinen aikakauskirja 2006;122(20):2509-15.
2005: Uusitalo Liisa; Knip Mikael; Kenward Michael G; Alfthan Georg; Sundvall Jouko; Aro Antti; Reunanen Antti; Akerblom Hans K; Virtanen Suvi M;
Serum alpha-tocopherol concentrations and risk of type 1 diabetes mellitus: a cohort study in siblings of affected children.
Journal of pediatric endocrinology & metabolism : JPEM 2005;18(12):1409-16.
2005: Paajanen Laura; Korpela Riitta; Tuure Tuula; Honkanen Jarno; Järvelä Irma; Ilonen Jorma; Knip Mikael; Vaarala Outi; Kokkonen Jorma
Cow milk is not responsible for most gastrointestinal immune-like syndromes--evidence from a population-based study.
The American journal of clinical nutrition 2005;82(6):1327-35.
2005: Ronkainen Matti S; Härkönen Taina; Perheentupa Jaakko; Knip Mikael
Characterization of the humoral immune response to glutamic acid decarboxylase in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) and/or type 1 diabetes.
European journal of endocrinology / European Federation of Endocrine Societies 2005;153(6):901-6.
2005: Knip Mikael; Veijola Riitta; Virtanen Suvi M; Hyöty Heikki; Vaarala Outi; Akerblom Hans K
Environmental triggers and determinants of type 1 diabetes.
Diabetes 2005;54 Suppl 2():S125-36.
2005: Oling Viveka; Marttila Jane; Ilonen Jorma; Kwok William W; Nepom Gerald; Knip Mikael; Simell Olli; Reijonen Helena
GAD65- and proinsulin-specific CD4+ T-cells detected by MHC class II tetramers in peripheral blood of type 1 diabetes patients and at-risk subjects.
Journal of autoimmunity 2005;25(3):235-43.
2005: Simell Satu; Kupila Antti; Hoppu Sanna; Hekkala Anne; Simell Tuula; Ståhlberg Marja-Riitta; Viander Markku; Hurme Timo; Knip Mikael; Ilonen Jorma; Hyöty Heikki; Simell Olli
Natural history of transglutaminase autoantibodies and mucosal changes in children carrying HLA-conferred celiac disease susceptibility.
Scandinavian journal of gastroenterology 2005;40(10):1182-91.
2005: Hermann Robert; Mantere Jussi; Lipponen Kati; Veijola Riitta; Soltesz Gyula; Otonkoski Timo; Simell Olli; Knip Mikael; Ilonen Jorma
Lack of association of PAX4 gene with type 1 diabetes in the Finnish and Hungarian populations.
Diabetes 2005;54(9):2816-9.
2005: Hermann Robert; Laine A P; Veijola R; Vahlberg T; Simell S; Lähde J; Simell O; Knip M; Ilonen J
The effect of HLA class II, insulin and CTLA4 gene regions on the development of humoral beta cell autoimmunity.
Diabetologia 2005;48(9):1766-75.
2005: Vauhkonen Ilkka; Niskanen Leo; Knip Mikael; Mykkänen Leena Moilanen; Haffner Steven; Uusitupa Matti; Laakso Markku
Subtle hyperproinsulinaemia characterises the defective insulin secretory capacity in offspring of glutamic acid decarboxylase antibody-positive patients with latent autoimmune diabetes mellitus in adults.
European journal of endocrinology / European Federation of Endocrine Societies 2005;153(2):265-73.
2005: Mikkonen Kirsi; Knip Mikael; Pakarinen Arto J; Lanning Peter; Isojärvi Jouko I T; Vainionpää Leena K
Growth and lipid metabolism in girls and young women with epilepsy during pubertal maturation.
Epilepsia 2005;46(7):1114-20.
2005: Viskari H; Ludvigsson J; Uibo R; Salur L; Marciulionyte D; Hermann R; Soltesz G; Füchtenbusch M; Ziegler A-G; Kondrashova A; Romanov A; Kaplan B; Laron Z; Koskela P; Vesikari T; Huhtala H; Knip M; Hyöty H
Relationship between the incidence of type 1 diabetes and maternal enterovirus antibodies: time trends and geographical variation.
Diabetologia 2005;48(7):1280-7.
2005: Erkkola Maijaliisa; Kronberg-Kippilä Carina; Savilahti Erkki; Kenward Michael G; Salonen Marja; Ilonen Jorma; Knip Mikael; Akerblom Hans K; Virtanen Suvi M
Maternal consumption of dairy products during pregnancy and lactation, and the development of cow's milk antibodies in the offspring.
Acta paediatrica (Oslo, Norway : 1992) 2005;94(6):696-704.
2005: Kukko M; Kimpimäki T; Korhonen S; Kupila A; Simell S; Veijola R; Simell T; Ilonen J; Simell O; Knip M
Dynamics of diabetes-associated autoantibodies in young children with human leukocyte antigen-conferred risk of type 1 diabetes recruited from the general population.
The Journal of clinical endocrinology and metabolism 2005;90(5):2712-7.
2005: Akerblom H K; Virtanen S M; Ilonen J; Savilahti E; Vaarala O; Reunanen A; Teramo K; Hämäläinen A-M; Paronen J; Riikjärv M-A; Ormisson A; Ludvigsson J; Dosch H-M; Hakulinen T; Knip M;
Dietary manipulation of beta cell autoimmunity in infants at increased risk of type 1 diabetes: a pilot study.
Diabetologia 2005;48(5):829-37.
2005: Westerlund Annette; Ankelo Matti; Ilonen Jorma; Knip Mikael; Simell Olli; Hinkkanen Ari E
Absence of avidity maturation of autoantibodies to the protein tyrosine phosphatase-like IA-2 molecule and glutamic acid decarboxylase (GAD65) during progression to type 1 diabetes.
Journal of autoimmunity 2005;24(2):153-67.
2005: Erkkola M; Pigg H-M; Virta-Autio P; Hekkala A; Hyppönen E; Knip M; Virtanen S M
Infant feeding patterns in the Finnish type I diabetes prediction and prevention nutrition study cohort.
European journal of clinical nutrition 2005;59(1):107-13.
2005: Knip Mikael; Akerblom Hans K
Early nutrition and later diabetes risk.
Advances in experimental medicine and biology 2005;569():142-50.
2005: Kondrashova Anita; Reunanen Antti; Romanov Anatolij; Karvonen Aino; Viskari Hanna; Vesikari Timo; Ilonen Jorma; Knip Mikael; Hyöty Heikki
A six-fold gradient in the incidence of type 1 diabetes at the eastern border of Finland.
Annals of medicine 2005;37(1):67-72.
2004: Hoppu Sanna; Härkönen Taina; Ronkainen Matti S; Akerblom Hans K; Knip Mikael;
IA-2 antibody epitopes and isotypes during the prediabetic process in siblings of children with type 1 diabetes.
Journal of autoimmunity 2004;23(4):361-70.
2004: Devendra Devasenan; Franke Bernd; Galloway Tamara S; Horton Sara J; Knip Mikael; Wilkin Terence J
Distinct idiotypes of insulin autoantibody in autoimmune polyendocrine syndrome type 2 and childhood onset type 1 diabetes.
The Journal of clinical endocrinology and metabolism 2004;89(10):5266-70.
2004: Hermann R; Bartsocas C S; Soltész Gy; Vazeou A; Paschou P; Bozas E; Malamitsi-Puchner A; Simell O; Knip M; Ilonen J
Genetic screening for individuals at high risk for type 1 diabetes in the general population using HLA Class II alleles as disease markers. A comparison between three European populations with variable rates of disease incidence.
Diabetes/metabolism research and reviews 2004;20(4):322-9.
2004: Hoppu S; Ronkainen M S; Kulmala P; Akerblom H K; Knip M;
GAD65 antibody isotypes and epitope recognition during the prediabetic process in siblings of children with type I diabetes.
Clinical and experimental immunology 2004;136(1):120-8.
2004: Viskari Hanna; Ludvigsson Johnny; Uibo Raivo; Salur Lina; Marciulionyte Dalia; Hermann Robert; Soltesz Gyula; Füchtenbusch Martin; Ziegler Anette-G; Kondrashova Anita; Romanov Anatolij; Knip Mikael; Hyöty Heikki
Relationship between the incidence of type 1 diabetes and enterovirus infections in different European populations: results from the EPIVIR project.
Journal of medical virology 2004;72(4):610-7.
2004: Laine Antti-Pekka; Nejentsev Sergei; Veijola Riitta; Korpinen Eija; Sjöroos Minna; Simell Olli; Knip Mikael; Akerblom Hans K; Ilonen Jorma
A linkage study of 12 IDDM susceptibility loci in the Finnish population.
Diabetes/metabolism research and reviews 2004;20(2):144-9.
2004: Ronkainen M S; Savola K; Knip M
Antibodies to GAD65 epitopes at diagnosis and over the first 10 years of clinical type 1 diabetes mellitus.
Scandinavian journal of immunology 2004;59(3):334-40.
2004: Vainionpää Leena K; Mikkonen Kirsi; Rättyä Johanna; Knip Mikael; Pakarinen Arto J; Myllylä Vilho V; Isojärvi Jouko I T
Thyroid function in girls with epilepsy with carbamazepine, oxcarbazepine, or valproate monotherapy and after withdrawal of medication.
Epilepsia 2004;45(3):197-203.
2004: Kukko Marika; Virtanen Suvi M; Toivonen Anna; Simell Satu; Korhonen Sari; Ilonen Jorma; Simel Olli; Knip Mikael
Geographical variation in risk HLA-DQB1 genotypes for type 1 diabetes and signs of beta-cell autoimmunity in a high-incidence country.
Diabetes care 2004;27(3):676-81.
2004: Tiittanen Minna; Knip Mikael; Vaarala Outi
Anti-insulin activity in IgG-fractions from children with newly-diagnosed type 1 diabetes and negative for insulin autoantibodies.
Autoimmunity 2004;37(1):45-9.
2004: Salminen K K; Vuorinen T; Oikarinen S; Helminen M; Simell S; Knip M; Ilonen J; Simell O; Hyöty H
Isolation of enterovirus strains from children with preclinical Type 1 diabetes.
Diabetic medicine : a journal of the British Diabetic Association 2004;21(2):156-64.
2004: Mikkonen K; Vainionpää L K; Pakarinen A J; Knip M; Järvelä I Y; Tapanainen J S; Isojärvi J I
Long-term reproductive endocrine health in young women with epilepsy during puberty.
Neurology 2004;62(3):445-50.
2004: Hoppu Sanna; Ronkainen Matti S; Kimpimäki Teija; Simell Satu; Korhonen Sari; Ilonen Jorma; Simell Olli; Knip Mikael
Insulin autoantibody isotypes during the prediabetic process in young children with increased genetic risk of type 1 diabetes.
Pediatric research 2004;55(2):236-42.
2004: Marjamäki Liisa; Räsänen Minna; Uusitalo Liisa; Ahonen Suvi; Veijola Riitta; Knip Mikael; Virtanen Suvi Mirjami
Use of vitamin D and other dietary supplements by Finnish children at the age of 2 and 3 years.
International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition 2004;74(1):27-34.
2004: Toivonen Anna; Kulmala Petri; Rahko Jukka; Ilonen Jorma; Knip Mikael
Soluble adhesion molecules in Finnish schoolchildren with signs of preclinical type 1 diabetes.
Diabetes/metabolism research and reviews 2004;20(1):48-54.
2004: Laine A P; Hermann R; Knip M; Simell O; Akerblom H K; Ilonen J
The human leukocyte antigen genotype has a modest effect on the insulin gene polymorphism-associated susceptibility to type 1 diabetes in the Finnish population.
Tissue antigens 2004;63(1):72-4.
2004: Airas Laura; Korja Miikka; Soinio Minna; Nuutila Pirjo; Knip Mikael; Marttila Reijo J
[Stiff person syndrome]
Duodecim; lääketieteellinen aikakauskirja 2004;120(15):1899-902.
2004: Knip Mikael
[Is diabetes mellitus, type I an autoimmune disease and can we prevent its onset?]
Duodecim; lääketieteellinen aikakauskirja 2004;120(9):1158-65.
2004: Komulainen Jorma; Lounamaa Raisa; Sipilä Ilkka; Knip Mikael
[The criteria for good care of children and adolescents with diabetes]
Duodecim; lääketieteellinen aikakauskirja 2004;120(9):1135-7.
2003: Mrena S; Savola K; Kulmala P; Akerblom H K; Knip M;
Natural course of preclinical type 1 diabetes in siblings of affected children.
Acta paediatrica (Oslo, Norway : 1992) 2003;92(12):1403-10.
2003: Knip Mikael
Cow's milk antibodies in patients with newly diagnosed type 1 diabetes: primary or secondary?
Pediatric diabetes 2003;4(4):155-6.
2003: Virtanen Suvi M; Knip Mikael
Nutritional risk predictors of beta cell autoimmunity and type 1 diabetes at a young age.
The American journal of clinical nutrition 2003;78(6):1053-67.
2003: Gombos Zsofia; Hermann Robert; Veijola Riitta; Knip Mikael; Simell Olli; Pöllänen Pasi; Ilonen Jorma
Androgen receptor gene exon 1 CAG repeat polymorphism in Finnish patients with childhood-onset type 1 diabetes.
European journal of endocrinology / European Federation of Endocrine Societies 2003;149(6):597-600.
2003: Turpeinen Hannu; Hermann Robert; Vaara Satu; Laine Antti-Pekka; Simell Olli; Knip Mikael; Veijola Riitta; Ilonen Jorma
Vitamin D receptor polymorphisms: no association with type 1 diabetes in the Finnish population.
European journal of endocrinology / European Federation of Endocrine Societies 2003;149(6):591-6.
2003: Røste Line Sveberg; Taubøll Erik; Isojarvi Jouko I T; Berner Aasmund; Berg Kjell Andersen; Pakarinen Arto J; Huhtaniemi Ilpo T; Knip Mikael; Gjerstad Leif
Gonadal morphology and sex hormones in male and female Wistar rats after long-term lamotrigine treatment.
Seizure : the journal of the British Epilepsy Association 2003;12(8):621-7.
2003: Knip Mikael
Environmental triggers and determinants of beta-cell autoimmunity and type 1 diabetes.
Reviews in endocrine & metabolic disorders 2003;4(3):213-23.
2003: Kupila A; Sipilä J; Keskinen P; Simell T; Knip M; Pulkki K; Simell O
Intranasally administered insulin intended for prevention of type 1 diabetes--a safety study in healthy adults.
Diabetes/metabolism research and reviews 2003;19(5):415-20.
2003: Viskari H; Paronen J; Keskinen P; Simell S; Zawilinska B; Zgorniak-Nowosielska I; Korhonen S; Ilonen J; Simell O; Haapala A-M; Knip M; Hyöty H
Humoral beta-cell autoimmunity is rare in patients with the congenital rubella syndrome.
Clinical and experimental immunology 2003;133(3):378-83.
2003: Turpeinen H; Laine A P; Hermann R; Simell O; Veijola R; Knip M; Ilonen J
A linkage analysis of the CTLA4 gene region in Finnish patients with type 1 diabetes.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics 2003;30(4):289-93.
2003: Hermann R; Turpeinen H; Laine A P; Veijola R; Knip M; Simell O; Sipilä I; Akerblom H K; Ilonen J
HLA DR-DQ-encoded genetic determinants of childhood-onset type 1 diabetes in Finland: an analysis of 622 nuclear families.
Tissue antigens 2003;62(2):162-9.
2003: Sadeharju K; Knip M; Hiltunen M; Akerblom H K; Hyöty H
The HLA-DR phenotype modulates the humoral immune response to enterovirus antigens.
Diabetologia 2003;46(8):1100-5.
2003: Mäki Markku; Mustalahti Kirsi; Kokkonen Jorma; Kulmala Petri; Haapalahti Mila; Karttunen Tuomo; Ilonen Jorma; Laurila Kaija; Dahlbom Ingrid; Hansson Tony; Höpfl Peter; Knip Mikael
Prevalence of Celiac disease among children in Finland.
The New England journal of medicine 2003;348(25):2517-24.
2003: Mrena S; Savola K; Kulmala P; Reijonen H; Ilonen J; Akerblom H K; Knip M;
Genetic modification of risk assessment based on staging of preclinical type 1 diabetes in siblings of affected children.
The Journal of clinical endocrinology and metabolism 2003;88(6):2682-9.
2003: Westerlund-Karlsson Annette; Suonpää Katriina; Ankelo Matti; Ilonen Jorma; Knip Mikael; Hinkkanen Ari E
Detection of autoantibodies to protein tyrosine phosphatase-like protein IA-2 with a novel time-resolved fluorimetric assay.
Clinical chemistry 2003;49(6 Pt 1):916-23.
2003: Ankelo Matti; Westerlund-Karlsson Annette; Ilonen Jorma; Knip Mikael; Savola Kaisa; Kankaanpää Pasi; Meriö Liisa; Siitari Harri; Hinkkanen Ari
Time-resolved fluorometric assay for detection of autoantibodies to glutamic acid decarboxylase (GAD65).
Clinical chemistry 2003;49(6 Pt 1):908-15.
2003: Sadeharju K; Hämäläinen A-M; Knip M; Lönnrot M; Koskela P; Virtanen S M; Ilonen J; Akerblom H K; Hyöty H;
Enterovirus infections as a risk factor for type I diabetes: virus analyses in a dietary intervention trial.
Clinical and experimental immunology 2003;132(2):271-7.
2003: Hermann R; Veijola R; Sipilä I; Knip M; Akerblom H K; Simell O; Ilonen J
-to: Pani MA, Van Autreve J, Van Der Auwera BJ, Gorus FK, Badenhoop K (2002) Non-transmitted maternal HLA DQ2 or DQ8 alleles and risk of Type I diabetes in offspring: the importance of foetal or post partum exposure to diabetogenic molecules. Diabetologia 45:1340-1343.
Diabetologia 2003;46(4):588-9; author reply 591-2.
2003: Toivonen A M; Kulmala P; Savola K; Akerblom H K; Knip M
Soluble adhesion molecules in pre-clinical Type 1 diabetes: a prospective study.
Diabetologia 2003;46(4):492-5.
2003: Knip M
Cow's milk and the new trials for prevention of type 1 diabetes.
Journal of endocrinological investigation 2003;26(3):265-7.
2003: Hermann R; Knip M; Veijola R; Simell O; Laine A-P; Akerblom H K; Groop P-H; Forsblom C; Pettersson-Fernholm K; Ilonen J;
Temporal changes in the frequencies of HLA genotypes in patients with Type 1 diabetes--indication of an increased environmental pressure?
Diabetologia 2003;46(3):420-5.
2003: Pylvänen V; Knip M; Pakarinen A J; Turkka J; Kotila M; Rättyä J; Myllylä V V; Isojärvi J I T
Fasting serum insulin and lipid levels in men with epilepsy.
Neurology 2003;60(4):571-4.
2003: Kukko M; Kimpimäki T; Kupila A; Korhonen S; Kulmala P; Savola K; Simell T; Keskinen P; Ilonen J; Simell O; Knip M
Signs of beta-cell autoimmunity and HLA-defined diabetes susceptibility in the Finnish population: the sib cohort from the Type 1 Diabetes Prediction and Prevention Study.
Diabetologia 2003;46(1):65-70.
2003: Salminen Kimmo; Sadeharju Karita; Lönnrot Maria; Vähäsalo Paula; Kupila Antti; Korhonen Sari; Ilonen Jorma; Simell Olli; Knip Mikael; Hyöty Heikki
Enterovirus infections are associated with the induction of beta-cell autoimmunity in a prospective birth cohort study.
Journal of medical virology 2003;69(1):91-8.
2003: Eskola Vesa; Vähäsalo Paula; Akerblom Hans K; Knip Mikael;
Increased frequency of islet cell antibodies in unaffected brothers of children with type 1 diabetes.
Hormone research 2003;59(4):195-200.
2003: Hahl Jarmo; Simell Tuula; Kupila Antti; Keskinen Päivi; Knip Mikael; Ilonen Jorma; Simell Olli
A simulation model for estimating direct costs of type 1 diabetes prevention.
PharmacoEconomics 2003;21(5):295-303.
2002: Keskinen P; Korhonen S; Kupila A; Veijola R; Erkkilä S; Savolainen H; Arvilommi P; Simell T; Ilonen J; Knip M; Simell O
First-phase insulin response in young healthy children at genetic and immunological risk for Type I diabetes.
Diabetologia 2002;45(12):1639-48.
2002: Salmi Marko; Stolen Craig; Jousilahti Pekka; Yegutkin Gennady G; Tapanainen Päivi; Janatuinen Tuula; Knip Mikael; Jalkanen Sirpa; Salomaa Veikko
Insulin-regulated increase of soluble vascular adhesion protein-1 in diabetes.
The American journal of pathology 2002;161(6):2255-62.
2002: Riihimaa P H; Suominen K; Knip M; Tapanainen P; Tolonen U
Cardiovascular autonomic reactivity is decreased in adolescents with Type 1 diabetes.
Diabetic medicine : a journal of the British Diabetic Association 2002;19(11):932-8.
2002: Sveberg Røste Line; Taubøll Erik; Isojärvi Jouko I T; Pakarinen Arto J; Huhtaniemi Ilpo T; Knip Mikael; Gjerstad Leif
Effects of chronic valproate treatment on reproductive endocrine hormones in female and male Wistar rats.
Reproductive toxicology (Elmsford, N.Y.) 2002;16(6):767-73.
2002: Kimpimäki T; Kulmala P; Savola K; Kupila A; Korhonen S; Simell T; Ilonen J; Simell O; Knip M
Natural history of beta-cell autoimmunity in young children with increased genetic susceptibility to type 1 diabetes recruited from the general population.
The Journal of clinical endocrinology and metabolism 2002;87(10):4572-9.
2002: Hämäläinen Anu-Maaria; Knip Mikael
Autoimmunity and familial risk of type 1 diabetes.
Current diabetes reports 2002;2(4):347-53.
2002: Riihimaa Päivi H; Knip Mikael; Ruokonen Aimo; Tapanainen Päivi
Lack of physiological suppression of circulating IGFBP-1 in puberty in patients with insulin-dependent diabetes mellitus.
European journal of endocrinology / European Federation of Endocrine Societies 2002;147(2):235-41.
2002: Turpeinen H; Laine A-P; Nejentsev S; Sjöroos M; Ilonen J; Simell O; Veijola R; Knip M; Akerblom H K; Knip M
CD86 gene polymorphisms: no association with Type I diabetes among Finnish subjects.
Diabetologia 2002;45(7):1041-2.
2002: Turpeinen H; Laine A-P; Nejentsev S; Sjöroos M; Ilonen J; Simell O; Veijola R; Knip M; Akerblom H K; Knip M
CD86 gene polymorphisms: no association with Type I diabetes among Finnish subjects.
Diabetologia 2002;45(7):1041-2.
2002: Blomqvist M; Juhela S; Erkkila S; Korhonen S; Simell T; Kupila A; Vaarala O; Simell O; Knip M; Ilonen J
Rotavirus infections and development of diabetes-associated autoantibodies during the first 2 years of life.
Clinical and experimental immunology 2002;128(3):511-5.
2002: Knip Mikael; Kukko Marika; Kulmala Petri; Veijola Riitta; Simell Olli; Akerblom Hans K; Ilonen Jorma
Humoral beta-cell autoimmunity in relation to HLA-defined disease susceptibility in preclinical and clinical type 1 diabetes.
American journal of medical genetics 2002;115(1):48-54.
2002: Ilonen Jorma; Sjöroos Minna; Knip Mikael; Veijola Riitta; Simell Olli; Akerblom Hans K; Paschou Peri; Bozas Evangelos; Havarani Beatrice; Malamitsi-Puchner Ariadne; Thymelli Joanna; Vazeou Andriani; Bartsocas Christos S
Estimation of genetic risk for type 1 diabetes.
American journal of medical genetics 2002;115(1):30-6.
2002: Akerblom Hans K; Vaarala Outi; Hyöty Heikki; Ilonen Jorma; Knip Mikael
Environmental factors in the etiology of type 1 diabetes.
American journal of medical genetics 2002;115(1):18-29.
2002: Pylvänen Virpi; Knip Mikael; Pakarinen Arto; Kotila Mervi; Turkka Jukka; Isojärvi Jouko I T
Serum insulin and leptin levels in valproate-associated obesity.
Epilepsia 2002;43(5):514-7.
2002: Nieminen Peter; Löppönen Tuija; Tolonen Uolevi; Lanning Peter; Knip Mikael; Löppönen Heikki
Growth and biochemical markers of growth in children with snoring and obstructive sleep apnea.
Pediatrics 2002;109(4):e55.
2002: Knip Mikael
Can we predict type 1 diabetes in the general population?
Diabetes care 2002;25(3):623-5.
2002: Kupila Antti; Keskinen Päivi; Simell Tuula; Erkkilä Satu; Arvilommi Paula; Korhonen Sari; Kimpimäki Teija; Sjöroos Minna; Ronkainen Matti; Ilonen Jorma; Knip Mikael; Simell Olli
Genetic risk determines the emergence of diabetes-associated autoantibodies in young children.
Diabetes 2002;51(3):646-51.
2002: Hämäläinen Anu-Maaria; Ilonen Jorma; Simell Olli; Savola Kaisa; Kulmala Petri; Kupila Antti; Simell Tuula; Erkkola Risto; Koskela Pentti; Knip Mikael
Prevalence and fate of type 1 diabetes-associated autoantibodies in cord blood samples from newborn infants of non-diabetic mothers.
Diabetes/metabolism research and reviews 2002;18(1):57-63.
2002: Korhonen Sari; Knip Maria M; Kulmala Petri; Savola Kaisa; Akerblom Hans K; Knip Mikael;
Autoantibodies to GAD, IA-2 and insulin in ICA-positive first-degree relatives of children with type 1 diabetes: a comparison between parents and siblings.
Diabetes/metabolism research and reviews 2002;18(1):43-8.
2002: Korhonen Sari; Knip Maria M; Kulmala Petri; Savola Kaisa; Akerblom Hans K; Knip Mikael;
Autoantibodies to GAD, IA-2 and insulin in ICA-positive first-degree relatives of children with type 1 diabetes: a comparison between parents and siblings.
Diabetes/metabolism research and reviews 2002;18(1):43-8.
2002: Kordonouri Olga; Hartmann Reinhard; Grüters-Kieslich Anette; Knip Mikael; Danne Thomas
Age-specific levels of diabetes-related GAD and IA-2 antibodies in healthy children and adults.
Journal of pediatric endocrinology & metabolism : JPEM 2002;15(1):47-52.
2002: Knip Mikael
Natural course of preclinical type 1 diabetes.
Hormone research 2002;57 Suppl 1():6-11.
2002: Zuppi Cecilia; Messana Irene; Tapanainen Päivi; Knip Mikael; Vincenzoni Federica; Giardina Bruno; Nuutinen Matti
Proton nuclear magnetic resonance spectral profiles of urine from children and adolescents with type 1 diabetes.
Clinical chemistry 2002;48(4):660-2.
2001: Heino L; Lönnrot M; Knip M; Kupila A; Erkkilä S; Toivonen A; Vähäsalo P; Ilonen J; Simell O; Hyöty H
No evidence of abnormal regulation of antibody response to coxsackievirus B4 antigen in prediabetic children.
Clinical and experimental immunology 2001;126(3):432-6.
2001: Hämäläinen A M; Savola K; Kulmala P K; Koskela P; Akerblom H K; Knip M;
Disease-associated autoantibodies during pregnancy and at birth in families affected by type 1 diabetes.
Clinical and experimental immunology 2001;126(2):230-5.
2001: Savola K; Läärä E; Vähäsalo P; Kulmala P; Akerblom H K; Knip M;
Dynamic pattern of disease-associated autoantibodies in siblings of children with type 1 diabetes: a population-based study.
Diabetes 2001;50(11):2625-32.
2001: Palmén T; Ahola H; Palgi J; Aaltonen P; Luimula P; Wang S; Jaakkola I; Knip M; Otonkoski T; Holthöfer H
Nephrin is expressed in the pancreatic beta cells.
Diabetologia 2001;44(10):1274-80.
2001: Kimpimäki T; Kupila A; Hämäläinen A M; Kukko M; Kulmala P; Savola K; Simell T; Keskinen P; Ilonen J; Simell O; Knip M
The first signs of beta-cell autoimmunity appear in infancy in genetically susceptible children from the general population: the Finnish Type 1 Diabetes Prediction and Prevention Study.
The Journal of clinical endocrinology and metabolism 2001;86(10):4782-8.
2001: Isojärvi J I; Taubøll E; Pakarinen A J; van Parys J; Rättyä J; Harbo H F; Dale P O; Fauser B C; Gjerstad L; Koivunen R; Knip M; Tapanainen J S
Altered ovarian function and cardiovascular risk factors in valproate-treated women.
The American journal of medicine 2001;111(4):290-6.
2001: Erkkola M; Karppinen M; Javanainen J; Räsänen L; Knip M; Virtanen S M
Validity and reproducibility of a food frequency questionnaire for pregnant Finnish women.
American journal of epidemiology 2001;154(5):466-76.
2001: Rättyä J; Pakarinen A J; Knip M; Repo-Outakoski M; Myllylä V V; Isojärvi J I
Early hormonal changes during valproate or carbamazepine treatment: a 3-month study.
Neurology 2001;57(3):440-4.
2001: Sadeharju K; Lönnrot M; Kimpimäki T; Savola K; Erkkilä S; Kalliokoski T; Savolainen P; Koskela P; Ilonen J; Simell O; Knip M; Hyöty H
Enterovirus antibody levels during the first two years of life in prediabetic autoantibody-positive children.
Diabetologia 2001;44(7):818-23.
2001: Riihimaa P H; Suominen K; Tolonen U; Jäntti V; Knip M; Tapanainen P
Peripheral nerve function is increasingly impaired during puberty in adolescents with type 1 diabetes.
Diabetes care 2001;24(6):1087-92.
2001: Ronkainen M S; Hämäläinen A M; Koskela P; Akerblom H K; Knip M;
Pregnancy induces nonimmunoglobulin insulin-binding activity in both maternal and cord blood serum.
Clinical and experimental immunology 2001;124(2):190-6.
2001: Isojärvi J I; Taubøll E; Tapanainen J S; Pakarinen A J; Laatikainen T J; Knip M; Myllylä V V
On the association between valproate and polycystic ovary syndrome: a response and an alternative view.
Epilepsia 2001;42(3):305-10.
2001: Kupila A; Muona P; Simell T; Arvilommi P; Savolainen H; Hämäläinen A M; Korhonen S; Kimpimäki T; Sjöroos M; Ilonen J; Knip M; Simell O;
Feasibility of genetic and immunological prediction of type I diabetes in a population-based birth cohort.
Diabetologia 2001;44(3):290-7.
2001: Kimpimäki T; Erkkola M; Korhonen S; Kupila A; Virtanen S M; Ilonen J; Simell O; Knip M
Short-term exclusive breastfeeding predisposes young children with increased genetic risk of Type I diabetes to progressive beta-cell autoimmunity.
Diabetologia 2001;44(1):63-9.
2001: Kulmala P; Rahko J; Savola K; Vähäsalo P; Sjöroos M; Reunanen A; Ilonen J; Knip M
Beta-cell autoimmunity, genetic susceptibility, and progression to type 1 diabetes in unaffected schoolchildren.
Diabetes care 2001;24(1):171-3.
2001: Rättyä J; Turkka J; Pakarinen A J; Knip M; Kotila M A; Lukkarinen O; Myllylä V V; Isojärvi J I
Reproductive effects of valproate, carbamazepine, and oxcarbazepine in men with epilepsy.
Neurology 2001;56(1):31-6.
2001: Toivonen A; Kulmala P; Savola K; Akerblom H K; Knip M; The Childhood Diabetes In Finl
Soluble adhesion molecules in preclinical type 1 diabetes. The Childhood Diabetes in Finland Study Group.
Pediatric research 2001;49(1):24-9.
2001: Erkkola M; Karppinen M; Knip M; Virtanen S
[Nutrition during pregnancy--do recommendations and practice meet?]
Duodecim; lääketieteellinen aikakauskirja 2001;117(2):149-55.
2001: Tapanainen P; Leinonen E; Ruokonen A; Knip M
Leptin concentrations are elevated in newborn infants of diabetic mothers.
Hormone research 2001;55(4):185-90.
2001: Kimpimäki T; Knip M
Disease-associated autoantibodies as predictive markers of type 1 diabetes mellitus in siblings of affected children.
Journal of pediatric endocrinology & metabolism : JPEM 2001;14 Suppl 1():575-87.
2000: Gylling M; Tuomi T; Björses P; Kontiainen S; Partanen J; Christie M R; Knip M; Perheentupa J; Miettinen A
ss-cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.
The Journal of clinical endocrinology and metabolism 2000;85(12):4434-40.
2000: Hyppönen E; Virtanen S M; Kenward M G; Knip M; Akerblom H K;
Obesity, increased linear growth, and risk of type 1 diabetes in children.
Diabetes care 2000;23(12):1755-60.
2000: Zavialov A; Ankelo M; Westerlund-Karlsson A; Knip M; Ilonen J; Hinkkanen A
Novel fusion proteins in the analysis of diabetes-associated autoantibodies to GAD65 and IA-2.
Journal of immunological methods 2000;246(1-2):91-6.
2000: Nejentsev S; Gombos Z; Laine A P; Veijola R; Knip M; Simell O; Vaarala O; Akerblom H K; Ilonen J
Non-class II HLA gene associated with type 1 diabetes maps to the 240-kb region near HLA-B.
Diabetes 2000;49(12):2217-21.
2000: Knip M; Douek I F; Moore W P; Gillmor H A; McLean A E; Bingley P J; Gale E A;
Safety of high-dose nicotinamide: a review.
Diabetologia 2000;43(11):1337-45.
2000: Hämäläinen A M; Ronkainen M S; Akerblom H K; Knip M
Postnatal elimination of transplacentally acquired disease-associated antibodies in infants born to families with type 1 diabetes. The Finnish TRIGR Study Group. Trial to Reduce IDDM in the Genetically at Risk.
The Journal of clinical endocrinology and metabolism 2000;85(11):4249-53.
2000: Otonkoski T; Roivainen M; Vaarala O; Dinesen B; Leipälä J A; Hovi T; Knip M
Neonatal Type I diabetes associated with maternal echovirus 6 infection: a case report.
Diabetologia 2000;43(10):1235-8.
2000: Paronen J; Knip M; Savilahti E; Virtanen S M; Ilonen J; Akerblom H K; Vaarala O
Effect of cow's milk exposure and maternal type 1 diabetes on cellular and humoral immunization to dietary insulin in infants at genetic risk for type 1 diabetes. Finnish Trial to Reduce IDDM in the Genetically at Risk Study Group.
Diabetes 2000;49(10):1657-65.
2000: Sabbah E; Savola K; Ebeling T; Kulmala P; Vähäsalo P; Ilonen J; Salmela P I; Knip M
Genetic, autoimmune, and clinical characteristics of childhood- and adult-onset type 1 diabetes.
Diabetes care 2000;23(9):1326-32.
2000: Ilonen J; Reijonen H; Green A; Reunanen A; Knip M; Simell O; Akerblom H K
Geographical differences within Finland in the frequency of HLA-DQ genotypes associated with type 1 diabetes susceptibility. The Childhood Diabetes in Finland Study Group.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics 2000;27(4):225-30.
2000: Lönnrot M; Korpela K; Knip M; Ilonen J; Simell O; Korhonen S; Savola K; Muona P; Simell T; Koskela P; Hyöty H
Enterovirus infection as a risk factor for beta-cell autoimmunity in a prospectively observed birth cohort: the Finnish Diabetes Prediction and Prevention Study.
Diabetes 2000;49(8):1314-8.
2000: Riihimaa P H; Knip M; Hirvelä H; Tapanainen P
Metabolic characteristics and urine albumin excretion rate in relation to pubertal maturation in Type 1 diabetes.
Diabetes/metabolism research and reviews 2000;16(4):269-75.
2000: Peltola J; Kulmala P; Isojärvi J; Saiz A; Latvala K; Palmio J; Savola K; Knip M; Keränen T; Graus F
Autoantibodies to glutamic acid decarboxylase in patients with therapy-resistant epilepsy.
Neurology 2000;55(1):46-50.
2000: Virtanen S M; Läärä E; Hyppönen E; Reijonen H; Räsänen L; Aro A; Knip M; Ilonen J; Akerblom H K
Cow's milk consumption, HLA-DQB1 genotype, and type 1 diabetes: a nested case-control study of siblings of children with diabetes. Childhood diabetes in Finland study group.
Diabetes 2000;49(6):912-7.
2000: Lönnrot M; Salminen K; Knip M; Savola K; Kulmala P; Leinikki P; Hyypiä T; Akerblom H K; Hyöty H
Enterovirus RNA in serum is a risk factor for beta-cell autoimmunity and clinical type 1 diabetes: a prospective study. Childhood Diabetes in Finland (DiMe) Study Group.
Journal of medical virology 2000;61(2):214-20.
2000: Kulmala P; Rahko J; Savola K; Vähäsalo P; Veijola R; Sjöroos M; Reunanen A; Ilonen J; Knip M
Stability of autoantibodies and their relation to genetic and metabolic markers of Type I diabetes in initially unaffected schoolchildren.
Diabetologia 2000;43(4):457-64.
2000: Kimpimäki T; Kulmala P; Savola K; Vähäsalo P; Reijonen H; Ilonen J; Akerblom H K; Knip M
Disease-associated autoantibodies as surrogate markers of type 1 diabetes in young children at increased genetic risk. Childhood Diabetes in Finland Study Group.
The Journal of clinical endocrinology and metabolism 2000;85(3):1126-32.
2000: Akerblom H K; Knip M; Vaarala O
VII International "Onnela" Workshop: gut immune system and type 1 diabetes mellitus held in Janakkala, Finland, June 25-26, 1998.
Journal of pediatric endocrinology & metabolism : JPEM 2000;13(3):333-7.
2000: Vauhkonen I; Niskanen L; Knip M; Ilonen J; Vanninen E; Kainulainen S; Uusitupa M; Laakso M
Impaired insulin secretion in non-diabetic offspring of probands with latent autoimmune diabetes mellitus in adults.
Diabetologia 2000;43(1):69-78.
2000: Kulmala P; Savola K; Reijonen H; Veijola R; Vähäsalo P; Karjalainen J; Tuomilehto-Wolf E; Ilonen J; Tuomilehto J; Akerblom H K; Knip M
Genetic markers, humoral autoimmunity, and prediction of type 1 diabetes in siblings of affected children. Childhood Diabetes in Finland Study Group.
Diabetes 2000;49(1):48-58.
1999: Nejentsev S; Sjöroos M; Soukka T; Knip M; Simell O; Lövgren T; Ilonen J
Population-based genetic screening for the estimation of Type 1 diabetes mellitus risk in Finland: selective genotyping of markers in the HLA-DQB1, HLA-DQA1 and HLA-DRB1 loci.
Diabetic medicine : a journal of the British Diabetic Association 1999;16(12):985-92.
1999: Lönnrot M; Knip M; Marciulionyte D; Rahko J; Urbonaite B; Moore W P; Vilja P; Hyöty H
Enterovirus antibodies in relation to islet cell antibodies in two populations with high and low incidence of type 1 diabetes.
Diabetes care 1999;22(12):2086-8.
1999: Hyppönen E; Kenward M G; Virtanen S M; Piitulainen A; Virta-Autio P; Tuomilehto J; Knip M; Akerblom H K
Infant feeding, early weight gain, and risk of type 1 diabetes. Childhood Diabetes in Finland (DiMe) Study Group.
Diabetes care 1999;22(12):1961-5.
1999: Komulainen J; Kulmala P; Savola K; Lounamaa R; Ilonen J; Reijonen H; Knip M; Akerblom H K
Clinical, autoimmune, and genetic characteristics of very young children with type 1 diabetes. Childhood Diabetes in Finland (DiMe) Study Group.
Diabetes care 1999;22(12):1950-5.
1999: Rantala H; Kulmala P; Savola K; Knip M
Absence of glutamic acid decarboxylase antibodies in childhood epilepsies.
Pediatric neurology 1999;21(5):794-6.
1999: Klemetti P; Hyöty H; Roivainen M; Ilonen J; Savola K; Knip M; Akerblom H K; Vaarala O
Relation between T-cell responses to glutamate decarboxylase and coxsackievirus B4 in patients with insulin-dependent diabetes mellitus.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 1999;14(2):95-105.
1999: Mrena S; Savola K; Kulmala P; Akerblom H K; Knip M
Staging of preclinical type 1 diabetes in siblings of affected children. Childhood Diabetes in Finland Study Group.
Pediatrics 1999;104(4 Pt 1):925-30.
1999: Adojaan B; Sabbah E; Vähäsalo P; Akerblom H K; Podar T; Knip M
Glutamic acid decarboxylase and islet cell antibodies in healthy Estonian children.
Journal of pediatric endocrinology & metabolism : JPEM 1999;12(5):667-72.
1999: Arikoski P; Komulainen J; Riikonen P; Voutilainen R; Knip M; Kröger H
Alterations in bone turnover and impaired development of bone mineral density in newly diagnosed children with cancer: a 1-year prospective study.
The Journal of clinical endocrinology and metabolism 1999;84(9):3174-81.
1999: Vaarala O; Knip M; Paronen J; Hämäläinen A M; Muona P; Väätäinen M; Ilonen J; Simell O; Akerblom H K
Cow's milk formula feeding induces primary immunization to insulin in infants at genetic risk for type 1 diabetes.
Diabetes 1999;48(7):1389-94.
1999: Juhela S; Hyöty H; Hinkkanen A; Elliott J F; Roivainen M; Kulmala P; Rahko J; Knip M; Ilonen J
T cell responses to enterovirus antigens and to beta-cell autoantigens in unaffected children positive for IDDM-associated autoantibodies.
Journal of autoimmunity 1999;12(4):269-78.
1999: Sabbah E; Savola K; Kulmala P; Veijola R; Vähäsalo P; Karjalainen J; Akerblom H K; Knip M
Diabetes-associated autoantibodies in relation to clinical characteristics and natural course in children with newly diagnosed type 1 diabetes. The Childhood Diabetes In Finland Study Group.
The Journal of clinical endocrinology and metabolism 1999;84(5):1534-9.
1999: Vainionpää L K; Rättyä J; Knip M; Tapanainen J S; Pakarinen A J; Lanning P; Tekay A; Myllylä V V; Isojärvi J I
Valproate-induced hyperandrogenism during pubertal maturation in girls with epilepsy.
Annals of neurology 1999;45(4):444-50.
1999: Sabbah E; Savola K; Kulmala P; Reijonen H; Veijola R; Vähäsalo P; Karjalainen J; Ilonen J; Akerblom H K; Knip M
Disease-associated autoantibodies and HLA-DQB1 genotypes in children with newly diagnosed insulin-dependent diabetes mellitus (IDDM). The Childhood Diabetes in Finland Study Group.
Clinical and experimental immunology 1999;116(1):78-83.
1999: Rättyä J; Vainionpää L; Knip M; Lanning P; Isojärvi J I
The effects of valproate, carbamazepine, and oxcarbazepine on growth and sexual maturation in girls with epilepsy.
Pediatrics 1999;103(3):588-93.
1999: Petersen J S; Kulmala P; Clausen J T; Knip M; Dyrberg T
Progression to type 1 diabetes is associated with a change in the immunoglobulin isotype profile of autoantibodies to glutamic acid decarboxylase (GAD65). Childhood Diabetes in Finland Study Group.
Clinical immunology (Orlando, Fla.) 1999;90(2):276-81.
1999: Kerokoski P; Ilonen J; Gaedigk R; Dosch H M; Knip M; Hakala M; Hinkkanen A
Production of the islet cell antigen ICA69 (p69) with baculovirus expression system: analysis with a solid-phase time-resolved fluorescence method of sera from patients with IDDM and rheumatoid arthritis.
Autoimmunity 1999;29(4):281-9.
1998: Nejentsev S; Koskinen S; Sjöroos M; Reijonen H; Schwartz E I; Kovalchuk L; Sochnev A; Adojaan B; Podar T; Knip M; Simell O; Koskenvuo M; Akerblom H K; Ilonen J
Distribution of insulin-dependent diabetes mellitus (IDDM)-related HLA alleles correlates with the difference in IDDM incidence in four populations of the Eastern Baltic region.
Tissue antigens 1998;52(5):473-7.
1998: Savola K; Sabbah E; Kulmala P; Vähäsalo P; Ilonen J; Knip M
Autoantibodies associated with Type I diabetes mellitus persist after diagnosis in children.
Diabetologia 1998;41(11):1293-7.
1998: Erkkola M; Karppinen M; Järvinen A; Knip M; Virtanen S M
Folate, vitamin D, and iron intakes are low among pregnant Finnish women.
European journal of clinical nutrition 1998;52(10):742-8.
1998: Virtanen S M; Hyppönen E; Läärä E; Vähäsalo P; Kulmala P; Savola K; Räsänen L; Aro A; Knip M; Akerblom H K
Cow's milk consumption, disease-associated autoantibodies and type 1 diabetes mellitus: a follow-up study in siblings of diabetic children. Childhood Diabetes in Finland Study Group.
Diabetic medicine : a journal of the British Diabetic Association 1998;15(9):730-8.
1998: Roivainen M; Knip M; Hyöty H; Kulmala P; Hiltunen M; Vähäsalo P; Hovi T; Akerblom H K
Several different enterovirus serotypes can be associated with prediabetic autoimmune episodes and onset of overt IDDM. Childhood Diabetes in Finland (DiMe) Study Group.
Journal of medical virology 1998;56(1):74-8.
1998: Leinonen J S; Alho H; Harmoinen A; Lehtimäki T; Knip M
Unaltered antioxidant activity of plasma in subjects at increased risk for IDDM.
Free radical research 1998;29(2):159-64.
1998: Ilonen J; Simell O; Knip M; Akerblom H K
Screening for genetic IDDM risk and prevention trials in infancy.
Diabetes/metabolism reviews 1998;14(2):188.
1998: Arikoski P; Komulainen J; Voutilainen R; Riikonen P; Parviainen M; Tapanainen P; Knip M; Kröger H
Reduced bone mineral density in long-term survivors of childhood acute lymphoblastic leukemia.
Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology 1998;20(3):234-40.
1998: Lönnrot M; Knip M; Roivainen M; Koskela P; Akerblom H K; Hyöty H
Onset of type 1 diabetes mellitus in infancy after enterovirus infections.
Diabetic medicine : a journal of the British Diabetic Association 1998;15(5):431-4.
1998: Knip M; Akerblom H K
IDDM prevention trials in progress--a critical assessment.
Journal of pediatric endocrinology & metabolism : JPEM 1998;11 Suppl 2():371-7.
1998: Savola K; Bonifacio E; Sabbah E; Kulmala P; Vähäsalo P; Karjalainen J; Tuomilehto-Wolf E; Meriläinen J; Akerblom H K; Knip M
IA-2 antibodies--a sensitive marker of IDDM with clinical onset in childhood and adolescence. Childhood Diabetes in Finland Study Group.
Diabetologia 1998;41(4):424-9.
1998: Isojärvi J I; Rättyä J; Myllylä V V; Knip M; Koivunen R; Pakarinen A J; Tekay A; Tapanainen J S
Valproate, lamotrigine, and insulin-mediated risks in women with epilepsy.
Annals of neurology 1998;43(4):446-51.
1998: Komulainen J; Knip M; Sabbah E; Vähäsalo P; Lounamaa R; Akerblom H K; Reijonen H; Ilonen J
Autoimmune and clinical characteristics of type I diabetes in children with different genetic risk loads defined by HLA-DQB1 alleles. Childhood Diabetes in Finland Study Group.
Clinical science (London, England : 1979) 1998;94(3):263-9.
1998: Akerblom H K; Knip M
Putative environmental factors in Type 1 diabetes.
Diabetes/metabolism reviews 1998;14(1):31-67.
1998: Löppönen T; Saukkonen A L; Serlo W; Tapanainen P; Ruokonen A; Lanning P; Knip M
Pituitary function in children with hydrocephalus before and after the first shunting operation.
European journal of endocrinology / European Federation of Endocrine Societies 1998;138(2):170-5.
1998: Hahl J; Simell T; Ilonen J; Knip M; Simell O
Costs of predicting IDDM.
Diabetologia 1998;41(1):79-85.
1998: Kulmala P; Savola K; Petersen J S; Vähäsalo P; Karjalainen J; Löppönen T; Dyrberg T; Akerblom H K; Knip M
Prediction of insulin-dependent diabetes mellitus in siblings of children with diabetes. A population-based study. The Childhood Diabetes in Finland Study Group.
The Journal of clinical investigation 1998;101(2):327-36.
1998: Raudaskoski T; Knip M; Laatikainen T
Plasma insulin-like growth factor-I and its binding proteins 1 and 3 during continuous nonoral and oral combined hormone replacement therapy.
Menopause (New York, N.Y.) 1998;5(4):217-22.
1997: Tapanainen P; Knip M; Risteli L; Kemppainen L; Käär M L; Risteli J
Collagen metabolites in the prediction of response to GH therapy in short children.
European journal of endocrinology / European Federation of Endocrine Societies 1997;137(6):621-5.
1997: Akerblom H K; Knip M; Simell O
From pathomechanisms to prediction, prevention and improved care of insulin-dependent diabetes mellitus in children.
Annals of medicine 1997;29(5):383-5.
1997: Löppönen T; Saukkonen A L; Serlo W; Tapanainen P; Ruokonen A; Knip M
Reduced levels of growth hormone, insulin-like growth factor-I and binding protein-3 in patients with shunted hydrocephalus.
Archives of disease in childhood 1997;77(1):32-7.
1997: Komulainen J; Knip M; Lounamaa R; Vähäsalo P; Karjalainen J; Sabbah E; Akerblom H K
Poor beta-cell function after the clinical manifestation of type 1 diabetes in children initially positive for islet cell specific autoantibodies. The Childhood Diabetes in Finland Study Group.
Diabetic medicine : a journal of the British Diabetic Association 1997;14(7):532-7.
1997: Löppönen T; Pääkkö E; Laitinen J; Saukkonen A L; Serlo W; Tapanainen P; Ruokonen A; Pirttiniemi P; Poikela A; Knip M
Pituitary size and function in children and adolescents with shunted hydrocephalus.
Clinical endocrinology 1997;46(6):691-9.
1997: Akerblom H K; Knip M
Prevention of IDDM: strategies based on new observations of molecular pathogenesis. Workshop held in Majvik, Kirkkonummi, Finland, 6-8 May 1996.
Diabetologia 1997;40(6):743-8.
1997: Ilonen J; Koskinen S; Nejentsev S; Sjöroos M; Knip M; Schwartz E I; Adojaan B; Kovalchuk L; Sochnevs A
HLA-DQB1*0304-DRB1*0408 haplotype associated with insulin-dependent diabetes mellitus in populations in the eastern Baltic region.
Tissue antigens 1997;49(5):532-4.
1997: Martikainen H; Salmela P; Nuojua-Huttunen S; Perälä J; Leinonen S; Knip M; Ruokonen A
Insulin-like growth factors and their binding proteins in the venous effluents of ovary and adrenal gland in severely hyperandrogenic women.
Human reproduction (Oxford, England) 1997;12(3):446-8.
1997: Hiltunen M; Hyöty H; Knip M; Ilonen J; Reijonen H; Vähäsalo P; Roivainen M; Lonnrot M; Leinikki P; Hovi T; Akerblom H K
Islet cell antibody seroconversion in children is temporally associated with enterovirus infections. Childhood Diabetes in Finland (DiMe) Study Group.
The Journal of infectious diseases 1997;175(3):554-60.
1997: Lahtela J T; Knip M; Paul R; Antonen J; Salmi J
Severe antibody-mediated human insulin resistance: successful treatment with the insulin analog lispro. A case report.
Diabetes care 1997;20(1):71-3.
1997: Peterson P; Salmi H; Hyöty H; Miettinen A; Ilonen J; Reijonen H; Knip M; Akerblom H K; Krohn K
Steroid 21-hydroxylase autoantibodies in insulin-dependent diabetes mellitus. Childhood Diabetes in Finland (DiMe) Study Group.
Clinical immunology and immunopathology 1997;82(1):37-42.
1996: Vähäsalo P; Knip M; Karjalainen J; Tuomilehto-Wolf E; Lounamaa R; Akerblom H K
Islet cell-specific autoantibodies in children with insulin-dependent diabetes mellitus and their siblings at clinical manifestation of the disease. Childhood Diabetes in Finland Study Group.
European journal of endocrinology / European Federation of Endocrine Societies 1996;135(6):689-95.
1996: Veijola R; Reijonen H; Vähäsalo P; Sabbah E; Kulmala P; Ilonen J; Akerblom H K; Knip M
HLA-DQB1-defined genetic susceptibility, beta cell autoimmunity, and metabolic characteristics in familial and nonfamilial insulin-dependent diabetes mellitus. Childhood Diabetes in Finland (DiMe) Study Group.
The Journal of clinical investigation 1996;98(11):2489-95.
1996: Adojaan B; Knip M; Vähásalo P; Karjalainen J; Kalits I; Akerblom H K
Relationship between the incidence of childhood IDDM and the frequency of ICA positivity in nondiabetic children in the general population.
Diabetes care 1996;19(12):1452-4.
1996: Martikainen A; Saukkonen T; Kulmala P K; Reijonen H; Ilonen J; Teramo K; Koskela P; Knip M; Akerblom H K
Disease-associated antibodies in offspring of mothers with IDDM.
Diabetes 1996;45(12):1706-10.
1996: Komulainen J; Lounamaa R; Knip M; Kaprio E A; Akerblom H K
Ketoacidosis at the diagnosis of type 1 (insulin dependent) diabetes mellitus is related to poor residual beta cell function. Childhood Diabetes in Finland Study Group.
Archives of disease in childhood 1996;75(5):410-5.
1996: Halminen M; Veijola R; Reijonen H; Ilonen J; Akerblom H K; Knip M
Effect of polymorphism in the insulin gene region on IDDM susceptibility and insulin secretion. The Childhood Diabetes in Finland (DiMe) Study Group.
European journal of clinical investigation 1996;26(10):847-52.
1996: Martikainen H; Salmela P; Nuojua-Huttunen S; Perälä J; Leinonen S; Knip M; Ruokonen A
Adrenal steroidogenesis is related to insulin in hyperandrogenic women.
Fertility and sterility 1996;66(4):564-70.
1996: Karjalainen J; Vähasalo P; Knip M; Tuomilehto-Wolf E; Virtala E; Akerblom H K
Islet cell autoimmunity and progression to insulin-dependent diabetes mellitus in genetically high- and low-risk siblings of diabetic children. The Childhood Diabetes in Finland (DiMe) Study Group.
European journal of clinical investigation 1996;26(8):640-9.
1996: Ilonen J; Reijonen H; Herva E; Sjöroos M; Iitiä A; Lövgren T; Veijola R; Knip M; Akerblom H K
Rapid HLA-DQB1 genotyping for four alleles in the assessment of risk for IDDM in the Finnish population. The Childhood Diabetes in Finland (DiMe) Study Group.
Diabetes care 1996;19(8):795-800.
1996: Talvensaari K K; Lanning M; Tapanainen P; Knip M
Long-term survivors of childhood cancer have an increased risk of manifesting the metabolic syndrome.
The Journal of clinical endocrinology and metabolism 1996;81(8):3051-5.
1996: Veijola R; Knip M; Puukka R; Reijonen H; Cox D W; Ilonen J
The immunoglobulin heavy-chain variable region in insulin-dependent diabetes mellitus: affected-sib-pair analysis and association studies.
American journal of human genetics 1996;59(2):462-70.
1996: Ekman A C; Vakkuri O; Ekman M; Leppäluoto J; Ruokonen A; Knip M
Ethanol decreases nocturnal plasma levels of thyrotropin and growth hormone but not those of thyroid hormones or prolactin in man.
The Journal of clinical endocrinology and metabolism 1996;81(7):2627-32.
1996: Sabbah E; Kulmala P; Veijola R; Vähäsalo P; Karjalainen J; Tuomilehto-Wolf E; Akerblom H K; Knip M
Glutamic acid decarboxylase antibodies in relation to other autoantibodies and genetic risk markers in children with newly diagnosed insulin-dependent diabetes. Childhood Diabetes in Finland Study Group.
The Journal of clinical endocrinology and metabolism 1996;81(7):2455-9.
1996: Lönnrot M; Hyöty H; Knip M; Roivainen M; Kulmala P; Leinikki P; Akerblom H K
Antibody cross-reactivity induced by the homologous regions in glutamic acid decarboxylase (GAD65) and 2C protein of coxsackievirus B4. Childhood Diabetes in Finland Study Group.
Clinical and experimental immunology 1996;104(3):398-405.
1996: Löppönen T; Saukkonen A L; Serlo W; Tapanainen P; Ruokonen A; Knip M
Accelerated pubertal development in patients with shunted hydrocephalus.
Archives of disease in childhood 1996;74(6):490-6.
1996: Isojärvi J I; Laatikainen T J; Knip M; Pakarinen A J; Juntunen K T; Myllylä V V
Obesity and endocrine disorders in women taking valproate for epilepsy.
Annals of neurology 1996;39(5):579-84.
1996: Talvensaari K K; Knip M; Lanning P; Lanning M
Clinical characteristics and factors affecting growth in long-term survivors of cancer.
Medical and pediatric oncology 1996;26(3):166-72.
1996: Vähäsalo P; Petäys T; Knip M; Miettinen A; Saukkonen T; Karjalainen J; Savilahti E; Akerblom H K
Relation between antibodies to islet cell antigens, other autoantigens and cow's milk proteins in diabetic children and unaffected siblings at the clinical manifestation of IDDM. The Childhood Diabetes in Finland Study Group.
Autoimmunity 1996;23(3):165-74.
1995: Knip M; Tapanainen P; Pekonen F; Blum W F
Insulin-like growth factor binding proteins in prepubertal children with insulin-dependent diabetes mellitus.
European journal of endocrinology / European Federation of Endocrine Societies 1995;133(4):440-4.
1995: Knip M; Ekman A C; Ekman M; Leppäluoto J; Vakkuri O
Ethanol induces a paradoxical simultaneous increase in circulating concentrations of insulin-like growth factor binding protein-1 and insulin.
Metabolism: clinical and experimental 1995;44(10):1356-9.
1995: Raitakari O T; Porkka K V; Rönnemaa T; Knip M; Uhari M; Akerblom H K; Viikari J S
The role of insulin in clustering of serum lipids and blood pressure in children and adolescents. The Cardiovascular Risk in Young Finns Study.
Diabetologia 1995;38(9):1042-50.
1995: Veijola R; Vähäsalo P; Tuomilehto-Wolf E; Reijonen H; Kulmala P; Ilonen J; Akerblom H K; Knip M
Human leukocyte antigen identity and DQ risk alleles in autoantibody-positive siblings of children with IDDM are associated with reduced early insulin response. Childhood Diabetes in Finland (DiMe) Study Group.
Diabetes 1995;44(9):1021-8.
1995: Hyöty H; Hiltunen M; Knip M; Laakkonen M; Vähäsalo P; Karjalainen J; Koskela P; Roivainen M; Leinikki P; Hovi T
A prospective study of the role of coxsackie B and other enterovirus infections in the pathogenesis of IDDM. Childhood Diabetes in Finland (DiMe) Study Group.
Diabetes 1995;44(6):652-7.
1995: Löppönen T; Saukkonen A L; Serlo W; Lanning P; Knip M
Slow prepubertal linear growth but early pubertal growth spurt in patients with shunted hydrocephalus.
Pediatrics 1995;95(6):917-23.
1995: Hiltunen M; Hyöty H; Karjalainen J; Leinikki P; Knip M; Lounamaa R; Akerblom H K
Serological evaluation of the role of cytomegalovirus in the pathogenesis of IDDM: a prospective study. The Childhood Diabetes in Finland Study Group.
Diabetologia 1995;38(6):705-10.
1995: Tapanainen P; Käär M L; Leppäluoto J; Huttunen N P; Knip M
Normal stimulated growth hormone secretion but low peripheral levels of insulin-like growth factor I in prepubertal children with insulin-dependent diabetes mellitus.
Acta paediatrica (Oslo, Norway : 1992) 1995;84(6):646-50.
1995: Nuutinen M; Kouvalainen K; Knip M
Good growth response to growth hormone treatment in the ring chromosome 15 syndrome.
Journal of medical genetics 1995;32(6):486-7.
1995: Veijola R; Knip M; Reijonen H; Vähäsalo P; Puukka R; Iionen J
Effect of genetic risk load defined by HLA-DQB1 polymorphism on clinical characteristics of IDDM in children.
European journal of clinical investigation 1995;25(2):106-12.
1994: Reijonen H; Vähäsalo P; Karjalainen J; Ilonen J; Akerblom H K; Knip M
HLA-DQB1 genotypes and islet cell antibodies in the identification of siblings at risk for insulin-dependent diabetes (IDDM) in Finland. Childhood Diabetes in Finland (DiMe) Study Group.
Journal of autoimmunity 1994;7(5):675-86.
1994: Talvensaari K K; Lanning M; Pääkkö E; Tapanainen P; Knip M
Pituitary size assessed with magnetic resonance imaging as a measure of growth hormone secretion in long term survivors of childhood cancer.
The Journal of clinical endocrinology and metabolism 1994;79(4):1122-7.
1994: Lahti E I; Knip M; Laatikainen T J
Plasma insulin-like growth factor I and its binding proteins 1 and 3 in postmenopausal patients with breast cancer receiving long term tamoxifen.
Cancer 1994;74(2):618-24.
1994: Pääkkö E; Löppönen T; Saukkonen A L; Pyhtinen J; Laitinen J; Serlo W; Knip M
Information value of magnetic resonance imaging in shunted hydrocephalus.
Archives of disease in childhood 1994;70(6):530-4; discussion 534-5.
1994: Knip M; Vähäsalo P; Karjalainen J; Lounamaa R; Akerblom H K
Natural history of preclinical IDDM in high risk siblings. Childhood Diabetes in Finland Study Group.
Diabetologia 1994;37(4):388-93.
1994: Virtanen S M; Saukkonen T; Savilahti E; Ylönen K; Räsänen L; Aro A; Knip M; Tuomilehto J; Akerblom H K
Diet, cow's milk protein antibodies and the risk of IDDM in Finnish children. Childhood Diabetes in Finland Study Group.
Diabetologia 1994;37(4):381-7.
1994: Reijonen H; Ilonen J; Akerblom H K; Knip M; Dosch H M
Multi-locus analysis of HLA class II genes in DR2-positive IDDM haplotypes in Finland. The "Childhood Diabetes in Finland" (DiMe) Study Group.
Tissue antigens 1994;43(1):1-6.
1994: Reijonen H; Ilonen J; Knip M
[The role of genes in the type-1 diabetes]
Duodecim; lääketieteellinen aikakauskirja 1994;110(7):695-706.
1993: Akerblom H K; Savilahti E; Saukkonen T T; Paganus A; Virtanen S M; Teramo K; Knip M; Ilonen J; Reijonen H; Karjalainen J
The case for elimination of cow's milk in early infancy in the prevention of type 1 diabetes: the Finnish experience.
Diabetes/metabolism reviews 1993;9(4):269-78.
1993: Knip M; Kääpä P; Koivisto M
Hormonal enteroinsular axis in newborn infants of insulin-treated diabetic mothers.
The Journal of clinical endocrinology and metabolism 1993;77(5):1340-4.
1993: Koivisto V A; Leirisalo-Repo M; Ebeling P; Tuominen J A; Knip M; Turunen U; Mandrup-Poulsen T; Pelkonen R
Seven years of remission in a type I diabetic patient.
Diabetes care 1993;16(7):990-5.
1993: Puistola U; Risteli L; Kauppila A; Knip M; Risteli J
Markers of type I and type III collagen synthesis in serum as indicators of tissue growth during pregnancy.
The Journal of clinical endocrinology and metabolism 1993;77(1):178-82.
1993: Veijola R; Knip M; Risteli L; Risteli J; Käär M L; Puukka R; Ilonen J
Clinical characteristics and circulating collagen and laminin metabolites in insulin-dependent diabetic children with joint and skin manifestations.
Pediatric research 1993;33(5):501-5.
1993: Parkkonen P; Hyöty H; Huupponen T; Leinikki P; Tuomilehto-Wolf E; Knip M
Defective HLA class II expression in monocytes of type 1 diabetic patients. The Childhood Diabetes in Finland Study Group.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1993;101(5):395-402.
1992: Tapanainen P; Knip M
Evaluation of growth hormone secretion and treatment.
Annals of medicine 1992;24(4):237-47.
1991: Reijonen H; Ilonen J; Knip M; Akerblom H K
HLA-DQB1 alleles and absence of Asp 57 as susceptibility factors of IDDM in Finland.
Diabetes 1991;40(12):1640-4.
1991: Akerblom H K; Knip M
Aetiology of insulin-dependent diabetes mellitus--a cornucopia for research?
Annals of medicine 1991;23(4):415-7.
1991: Reijonen H; Ilonen J; Knip M; Reunala T
Insulin-dependent diabetes mellitus associated with dermatitis herpetiformis: evidence for heterogeneity of HLA-associated genes.
Tissue antigens 1991;37(2):94-6.
1991: Rönnemaa T; Knip M; Lautala P; Viikari J; Uhari M; Leino A; Kaprio E A; Salo M K; Dahl M; Nuutinen E M
Serum insulin and other cardiovascular risk indicators in children, adolescents and young adults.
Annals of medicine 1991;23(1):67-72.
1991: Otonkoski T; Knip M; Wong I; Simell O
Lack of glucose-induced functional maturation during long-term culture of human fetal islet cells.
Life sciences 1991;48(22):2157-63.
1990: Reijonen H; Silvennoinen-Kassinen S; Ilonen J; Knip M
Lack of association of T cell receptor beta-chain constant region polymorphism with insulin-dependent diabetes mellitus in Finland.
Clinical and experimental immunology 1990;81(3):396-9.
1990: Reijonen H; Ilonen J; Knip M; Michelsen B; Akerblom H K
HLA-DQ beta-chain restriction fragment length polymorphism as a risk marker in type 1 (insulin-dependent) diabetes mellitus: a Finnish family study.
Diabetologia 1990;33(6):357-62.
1989: Huttunen N P; Länkelä S L; Knip M; Lautala P; Käär M L; Laasonen K; Puukka R
Effect of once-a-week training program on physical fitness and metabolic control in children with IDDM.
Diabetes care 1989;12(10):737-40.
1989: Tapanainen P; Rantala H; Leppäluoto J; Lautala P; Käär M L; Knip M
Nocturnal release of immunoreactive growth hormone-releasing hormone and growth hormone in normal children.
Pediatric research 1989;26(5):404-9.
1989: Karjalainen J; Salmela P; Ilonen J; Surcel H M; Knip M
A comparison of childhood and adult type I diabetes mellitus.
The New England journal of medicine 1989;320(14):881-6.
1989: Huttunen N P; Knip M; Käär M L; Puukka R; Akerblom H K
Clinical significance of urinary C-peptide excretion in children with insulin-dependent diabetes mellitus.
Acta paediatrica Scandinavica 1989;78(2):271-7.
1988: Tapanainen P; Risteli L; Knip M; Käär M L; Risteli J
Serum aminoterminal propeptide of type III procollagen: a potential predictor of the response to growth hormone therapy.
The Journal of clinical endocrinology and metabolism 1988;67(6):1244-9.
1988: Knip M; Lautala P; Puukka R
Reduced insulin removal and erythrocyte insulin binding in obese children.
European journal of pediatrics 1988;148(3):233-7.
1988: Otonkoski T; Knip M; Wong I; Simell O
Effects of growth hormone and insulin-like growth factor I on endocrine function of human fetal islet-like cell clusters during long-term tissue culture.
Diabetes 1988;37(12):1678-83.
1988: Tapanainen P; Knip M; Lautala P; Leppäluoto J
Variable plasma growth hormone (GH)-releasing hormone and GH responses to clonidine, L-dopa, and insulin in normal men.
The Journal of clinical endocrinology and metabolism 1988;67(4):845-9.
1988: Otonkoski T; Knip M; Panula P; Andersson S; Wong I; Goldman H; Simell O
Morphology, yield and functional integrity of islet-like cell clusters in tissue culture of human fetal pancreata obtained after different means of abortion.
Acta endocrinologica 1988;118(1):68-76.
1988: Lautala P; Puukka R; Knip M; Perkkilä L; Puukka M
Postnatal decrease in insulin binding to erythrocytes in infants of diabetic mothers.
The Journal of clinical endocrinology and metabolism 1988;66(4):696-701.
1988: Karjalainen J; Knip M; Hyöty H; Leinikki P; Ilonen J; Käär M L; Akerblom H K
Relationship between serum insulin autoantibodies, islet cell antibodies and Coxsackie-B4 and mumps virus-specific antibodies at the clinical manifestation of type 1 (insulin-dependent) diabetes.
Diabetologia 1988;31(3):146-52.
1988: Karjalainen J; Knip M; Mustonen A; Akerblom H K
Insulin autoantibodies at the clinical manifestation of type 1 (insulin-dependent) diabetes--a poor predictor of clinical course and antibody response to exogenous insulin.
Diabetologia 1988;31(3):129-33.
1988: Otonkoski T; Andersson S; Knip M; Simell O
Maturation of insulin response to glucose during human fetal and neonatal development. Studies with perifusion of pancreatic isletlike cell clusters.
Diabetes 1988;37(3):286-91.
1988: Ryhänen P; Knip M; Puukka R; Huttunen N P; Lahti Y; Perkkilä L
Gluco-regulatory response to intravenous glucose infusion in children undergoing surgery.
Anesthesiology 1988;68(1):147-52.
1987: Leppäluoto J; Tapanainen P; Knip M
Heat exposure elevates plasma immunoreactive growth hormone-releasing hormone levels in man.
The Journal of clinical endocrinology and metabolism 1987;65(5):1035-8.
1986: Puukka R; Knip M; Lautala P; Perkkilä L; Puukka M
Erythrocyte insulin binding in preterm newborn infants.
Pediatric research 1986;20(3):256-60.
1984: Mustonen A; Knip M; Huttunen N P; Puukka R; Käär M L; Akerblom H K
Evidence of delayed beta-cell destruction in type 1 (insulin-dependent) diabetic patients with persisting complement-fixing cytoplasmic islet cell antibodies.
Diabetologia 1984;27(4):421-6.
1984: Käär M L; Akerblom H K; Huttunen N P; Knip M; Säkkinen K
Metabolic control in children and adolescents with insulin-dependent diabetes mellitus.
Acta paediatrica Scandinavica 1984;73(1):102-8.
1983: Knip M; Puukka R; Lautala P; Leppilampi M; Puukka M
Basal insulin secretion and erythrocyte insulin binding in preterm and term newborn infants.
Biology of the neonate 1983;43(3-4):172-80.
1982: Knip M; Säkkinen A; Huttunen N P; Käär M L; Länkelä S; Mustonen A; Akerblom H K
Postinitial remission in diabetic children--an analysis of 178 cases.
Acta paediatrica Scandinavica 1982;71(6):901-8.

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