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Björn Knollmann

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Sabine Huke; Hyun S Hwang; Franz Baudenbacher; Sirish Bennuri; Michela Faggioni; Raghav Venkataraman; Björn C Knollmann
Focal energy deprivation underlies arrhythmia susceptibility in mice with calcium-sensitized myofilaments.
Derek S Steele; Hyun-Seok Hwang; Björn C Knollmann
Triple mode of action of flecainide in catecholaminergic polymorphic ventricular tachycardia.
Nagesh Chopra; Björn C Knollmann
Triadin regulates cardiac muscle couplon structure and microdomain Ca2+ signalling: a path towards ventricular arrhythmias.

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2013: Sabine Huke; Hyun S Hwang; Franz Baudenbacher; Sirish Bennuri; Michela Faggioni; Raghav Venkataraman; Björn C Knollmann
Focal energy deprivation underlies arrhythmia susceptibility in mice with calcium-sensitized myofilaments.
Circulation research 2013;112(10):1334-44.
2013: Derek S Steele; Hyun-Seok Hwang; Björn C Knollmann
Triple mode of action of flecainide in catecholaminergic polymorphic ventricular tachycardia.
Cardiovascular research 2013;98(2):326-7.
2013: Nagesh Chopra; Björn C Knollmann
Triadin regulates cardiac muscle couplon structure and microdomain Ca2+ signalling: a path towards ventricular arrhythmias.
Cardiovascular research 2013;98(2):187-91.
2013: Anuradha Kalyanasundaram; Björn C Knollmann; Veronique A LaCombe; Muthu Periasamy; Andriy Belevych; Lucia Brunello; Cynthia A Carnes; Paul M L Janssen; Sandor Gyørke
Up-regulation of sarcoplasmic reticulum Ca2+ uptake leads to cardiac hypertrophy, contractile dysfunction and early mortality in mice deficient in CASQ2.
Cardiovascular research 2013;98(2):297-306.
2013: Hiroshi Watanabe; Arnon Adler; Zahurul A Bhuiyan; Hennie Bikker; Minoru Horie; Prince J Kannankeril; Björn C Knollmann; Tohru Minamino; Ferran Roses-Noguer; Raphael Rosso; Naokata Sumitomo; Jan Till; Christian van der Werf; Christian Veltmann; Sami Viskin; Arthur A M Wilde
Effects of flecainide on exercise-induced ventricular arrhythmias and recurrences in genotype-negative patients with catecholaminergic polymorphic ventricular tachycardia.
Heart rhythm : the official journal of the Heart Rhythm Society 2013;10(4):542-7.
2013: Björn C Knollmann
Induced pluripotent stem cell-derived cardiomyocytes: boutique science or valuable arrhythmia model?
Circulation research 2013;112(6):969-76; discussion 976.
2013: Michela Faggioni; Hyun Seok Hwang; Prince J Kannankeril; Ineke Nederend; Christian van der Werf; Arthur A M Wilde; Björn C Knollmann
Accelerated sinus rhythm prevents catecholaminergic polymorphic ventricular tachycardia in mice and in patients.
Circulation research 2013;112(4):689-97.
2012: Wei Feng; Hyun Seok Hwang; Dmytro O Kryshtal; Isela T Padilla; Isaac N Pessah; Birgit Puschner; Asheesh K Tiwary; Tao Yang; Björn C Knollmann
Coordinated regulation of murine cardiomyocyte contractility by nanomolar (-)-epigallocatechin-3-gallate, the major green tea catechin.
Molecular pharmacology 2012;82(5):993-1000.
2012: Michela Faggioni; Dmytro O Kryshtal; Björn C Knollmann
Calsequestrin mutations and catecholaminergic polymorphic ventricular tachycardia.
Pediatric cardiology 2012;33(6):959-67.
2012: Tilmann Schober; Raghav Venkataraman; Dmytro Kryshtal; Franz J Baudenbacher; Oleksiy Gryshchenko; Sabine Huke; Hyun Seok Hwang; Björn C Knollmann
Myofilament Ca sensitization increases cytosolic Ca binding affinity, alters intracellular Ca homeostasis, and causes pause-dependent Ca-triggered arrhythmia.
Circulation research 2012;111(2):170-9.
2012: Young Soo Lee; Shien-Fong Lin; Mitsunori Maruyama; Hyung Wook Park; Kyoung-Suk Rhee; Changyu Shen; Huiyong Yin; Yu-Cheng Hsieh; Chia-Hsiang Hsueh; Hyun Seok Hwang; Björn C Knollmann; Po Cheng Chang; Peng-Sheng Chen
Ryanodine receptor inhibition potentiates the activity of Na channel blockers against spontaneous calcium elevations and delayed afterdepolarizations in Langendorff-perfused rabbit ventricles.
Heart rhythm : the official journal of the Heart Rhythm Society 2012;9(7):1125-32.
2012: Michela Faggioni; Björn C Knollmann
Calsequestrin 2 and arrhythmias.
American journal of physiology. Heart and circulatory physiology 2012;302(6):H1250-60.
2012: Raghav Venkataraman; Rene Harder; Mark R Holcomb; Björn C Knollmann; Franz Baudenbacher
Ratiometric imaging of calcium during ischemia-reperfusion injury in isolated mouse hearts using Fura-2.
Biomedical engineering online 2012;11():39.
2011: Hiroshi Watanabe; Björn C Knollmann
Mechanism underlying catecholaminergic polymorphic ventricular tachycardia and approaches to therapy.
Journal of electrocardiology 2011;44(6):650-5.
2011: Eleonora Savio Galimberti; Björn C Knollmann
Efficacy and potency of class I antiarrhythmic drugs for suppression of Ca2+ waves in permeabilized myocytes lacking calsequestrin.
Journal of molecular and cellular cardiology 2011;51(5):760-8.
2011: Hiroshi Watanabe; Derek S Steele; Björn C Knollmann
Mechanism of antiarrhythmic effects of flecainide in catecholaminergic polymorphic ventricular tachycardia.
Circulation research 2011;109(6):712-3.
2011: Hiroshi Watanabe; Tao Yang; Dina Myers Stroud; Naohito Tanabe; Dao W Wang; Thomas C Atack; Nagesh Chopra; Alfred L George; Lynn Hall; Louise Harris; Susan B Hipkens; Björn C Knollmann; Sabina Kupershmidt; Brenda Leake; John S Lowe; Mark Magnuson; Dan Mark Roden
Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro.
Circulation 2011;124(9):1001-11.
2011: Björn C Knollmann
Carvedilol tweaks calcium release to ease arrhythmias.
Nature medicine 2011;17(8):923-4.
2011: Nagesh Chopra; Björn C Knollmann
Gauging the risk of arrhythmic death by common genetic variants: resurgence of the sinister QT.
Circulation. Cardiovascular genetics 2011;4(3):221-2.
2011: Christian van der Werf; Prince J Kannankeril; Frederic Sacher; Andrew D Krahn; Sami Viskin; Antoine Leenhardt; Wataru Shimizu; Naokata Sumitomo; Frank A Fish; Zahurul A Bhuiyan; Albert R Willems; Maurits J van der Veen; Hiroshi Watanabe; Julien Laborderie; Michel Haïssaguerre; Björn C Knollmann; Arthur A M Wilde
Flecainide therapy reduces exercise-induced ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia.
Journal of the American College of Cardiology 2011;57(22):2244-54.
2011: Nagesh Chopra; Björn C Knollmann
Genetics of sudden cardiac death syndromes.
Current opinion in cardiology 2011;26(3):196-203.
2011: Hyun Seok Hwang; Can Hasdemir; Derek R Laver; Divya Mehra; Kutsal Turhan; Michela Faggioni; Huiyong Yin; Björn C Knollmann
Inhibition of cardiac Ca2+ release channels (RyR2) determines efficacy of class I antiarrhythmic drugs in catecholaminergic polymorphic ventricular tachycardia.
Circulation. Arrhythmia and electrophysiology 2011;4(2):128-35.
2010: Björn C Knollmann
Pacing lightly: optogenetics gets to the heart.
Nature methods 2010;7(11):889-91.
2010: Björn C Knollmann
Power and pitfalls of using transgenic mice to optimize therapy for CPVT: a need for prospective placebo-controlled clinical trials in genetic arrhythmia disorders.
Heart rhythm : the official journal of the Heart Rhythm Society 2010;7(11):1683-5.
2010: Sabine Huke; Björn C Knollmann
Increased myofilament Ca2+-sensitivity and arrhythmia susceptibility.
Journal of molecular and cellular cardiology 2010;48(5):824-33.
2010: Fredrick A Hilliard; Derek S Steele; Derek Laver; Zhaokang Yang; Sylvain J Le Marchand; Nagesh Chopra; David W Piston; Sabine Huke; Björn C Knollmann
Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass.
Journal of molecular and cellular cardiology 2010;48(2):293-301.
2010: Anuradha Kalyanasundaram; Naresh C Bal; Clara Franzini-Armstrong; Björn C Knollmann; Muthu Periasamy
The calsequestrin mutation CASQ2D307H does not affect protein stability and targeting to the junctional sarcoplasmic reticulum but compromises its dynamic regulation of calcium buffering.
The Journal of biological chemistry 2010;285(5):3076-83.
2009: Nagesh Chopra; Björn C Knollmann
Cardiac calsequestrin: the new kid on the block in arrhythmias.
Journal of cardiovascular electrophysiology 2009;20(10):1179-85.
2009: Björn C Knollmann
New roles of calsequestrin and triadin in cardiac muscle.
The Journal of physiology 2009;587(Pt 13):3081-7.
2009: Nagesh Chopra; Tao Yang; Parisa Asghari; Edwin D Moore; Sabine Huke; Brandy Akin; Robert A Cattolica; Claudio F Perez; Thinn Hlaing; Barbara E C Knollmann-Ritschel; Larry R Jones; Isaac N Pessah; Paul D Allen; Clara Franzini-Armstrong; Björn C Knollmann
Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(18):7636-41.
2009: Hiroshi Watanabe; Nagesh Chopra; Derek Laver; Hyun Seok Hwang; Sean S Davies; Daniel E Roach; Henry J Duff; Dan Mark Roden; Arthur A M Wilde; Björn C Knollmann
Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans.
Nature medicine 2009;15(4):380-3.
2008: Franz Baudenbacher; Tilmann Schober; Jose Renato Pinto; Veniamin Y Sidorov; Fredrick Hilliard; R John Solaro; James D Potter; Björn C Knollmann
Myofilament Ca2+ sensitization causes susceptibility to cardiac arrhythmia in mice.
The Journal of clinical investigation 2008;118(12):3893-903.
2008: Satish R Raj; Björn C Knollmann
The beat goes on--driven by a cardiac calcium clock?
Heart rhythm : the official journal of the Heart Rhythm Society 2008;5(5):701-3.
2008: Björn C Knollmann; Dan Mark Roden
A genetic framework for improving arrhythmia therapy.
Nature 2008;451(7181):929-36.
2007: Nagesh Chopra; Prince J Kannankeril; Tao Yang; Thinn Hlaing; Izabela Holinstat; Kristen Ettensohn; Karl Pfeifer; Brandy Akin; Larry R Jones; Clara Franzini-Armstrong; Björn C Knollmann
Modest reductions of cardiac calsequestrin increase sarcoplasmic reticulum Ca2+ leak independent of luminal Ca2+ and trigger ventricular arrhythmias in mice.
Circulation research 2007;101(6):617-26.
2007: Björn C Knollmann; Syevda G Sirenko; Qi Rong; Alexander N Katchman; Mathew C Casimiro; Karl Pfeifer; Steven N Ebert
Kcnq1 contributes to an adrenergic-sensitive steady-state K+ current in mouse heart.
Biochemical and biophysical research communications 2007;360(1):212-8.
2007: Tilmann Schober; Björn C Knollmann
Exercise after myocardial infarction improves contractility and decreases myofilament Ca2+ sensitivity.
Circulation research 2007;100(7):937-9.
2007: Björn C Knollmann; Tilmann Schober; Andreas O Petersen; Syevda G Sirenko; Michael R Franz
Action potential characterization in intact mouse heart: steady-state cycle length dependence and electrical restitution.
American journal of physiology. Heart and circulatory physiology 2007;292(1):H614-21.
2006: Kai Liu; Susan Hipkens; Tao Yang; Robert Abraham; Wei Zhang; Nagesh Chopra; Björn C Knollmann; Mark Magnuson; Dan Mark Roden
Recombinase-mediated cassette exchange to rapidly and efficiently generate mice with human cardiac sodium channels.
Genesis (New York, N.Y. : 2000) 2006;44(11):556-64.
2006: Björn C Knollmann; Nagesh Chopra; Thinn Hlaing; Brandy Akin; Tao Yang; Kristen Ettensohn; Barbara E C Knollmann; Kenneth D Horton; Neil J Weissman; Izabela Holinstat; Wei Zhang; Dan Mark Roden; Larry R Jones; Clara Franzini-Armstrong; Karl Pfeifer
Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia.
The Journal of clinical investigation 2006;116(9):2510-20.
2006: Syevda G Sirenko; James D Potter; Björn C Knollmann
Differential effect of troponin T mutations on the inotropic responsiveness of mouse hearts--role of myofilament Ca2+ sensitivity increase.
The Journal of physiology 2006;575(Pt 1):201-13.
2006: Dirk Westermann; Björn C Knollmann; Paul Steendijk; Susanne Rutschow; Alexander Riad; Matthias Pauschinger; James D Potter; Heinz-Peter Schultheiss; Carsten Tschöpe
Diltiazem treatment prevents diastolic heart failure in mice with familial hypertrophic cardiomyopathy.
European journal of heart failure 2006;8(2):115-21.
2005: Olga M Hernandez; Danuta Szczesna-Cordary; Björn C Knollmann; Todd Miller; Michael Bell; Jiaju Zhao; Syevda G Sirenko; Zoraida Diaz; Georgianna Guzman; Yuanyuan Xu; Ying Wang; W Glenn L Kerrick; James D Potter
F110I and R278C troponin T mutations that cause familial hypertrophic cardiomyopathy affect muscle contraction in transgenic mice and reconstituted human cardiac fibers.
The Journal of biological chemistry 2005;280(44):37183-94.
2005: Björn C Knollmann; Brendan J Smyth; Christine E Garnett; Anastasios N Salesiotis; Dragoslav M Gvozdjan; N Seth Berry; Howard Lee; F David Min
Personal digital assistant-based drug reference software as tools to improve rational prescribing: benchmark criteria and performance.
Clinical pharmacology and therapeutics 2005;78(1):7-18.
2005: Martin Morad; Lars Cleemann; Björn C Knollmann
Triadin: the new player on excitation-contraction coupling block.
Circulation research 2005;96(6):607-9.
2004: Mathew C Casimiro; Björn C Knollmann; Ebenezer N Yamoah; Liping Nie; Jay C Vary; Syevda G Sirenko; Anne E Greene; Alexander Grinberg; Sing-Ping Huang; Steven N Ebert; Karl Pfeifer
Targeted point mutagenesis of mouse Kcnq1: phenotypic analysis of mice with point mutations that cause Romano-Ward syndrome in humans.
Genomics 2004;84(3):555-64.
2004: Björn C Knollmann; Mathew C Casimiro; Alexander N Katchman; Syevda G Sirenko; Tilmann Schober; Qi Rong; Karl Pfeifer; Steven N Ebert
Isoproterenol exacerbates a long QT phenotype in Kcnq1-deficient neonatal mice: possible roles for human-like Kcnq1 isoform 1 and slow delayed rectifier K+ current.
The Journal of pharmacology and experimental therapeutics 2004;310(1):311-8.
2004: Joseph V Tranquillo; Michael R Franz; Björn C Knollmann; Alexandra P Henriquez; Doris Taylor; Craig S Henriquez
Genesis of the monophasic action potential: role of interstitial resistance and boundary gradients.
American journal of physiology. Heart and circulatory physiology 2004;286(4):H1370-81.
2003: Björn C Knollmann; Paulus Kirchhof; Syevda G Sirenko; Hubertus Degen; Anne E Greene; Tilmann Schober; Jessica C Mackow; Larissa Fabritz; James D Potter; Martin Morad
Familial hypertrophic cardiomyopathy-linked mutant troponin T causes stress-induced ventricular tachycardia and Ca2+-dependent action potential remodeling.
Circulation research 2003;92(4):428-36.
2002: Björn C Knollmann; Joseph Tranquillo; Syevda G Sirenko; Craig S Henriquez; Michael R Franz
Microelectrode study of the genesis of the monophasic action potential by contact electrode technique.
Journal of cardiovascular electrophysiology 2002;13(12):1246-52.
2002: David A Flockhart; Sally Usdin Yasuda; John C Pezzullo; Björn C Knollmann
Teaching rational prescribing: a new clinical pharmacology curriculum for medical schools.
Naunyn-Schmiedeberg's archives of pharmacology 2002;366(1):33-43.
2002: Susan Ji; Toshimasa Tosaka; Bernard H Whitfield; Alexander N Katchman; Abdurrahman Kandil; Björn C Knollmann; Steven N Ebert
Differential rate responses to nicotine in rat heart: evidence for two classes of nicotinic receptors.
The Journal of pharmacology and experimental therapeutics 2002;301(3):893-9.
2001: Björn C Knollmann; Alexander N Katchman; Michael R Franz
Monophasic action potential recordings from intact mouse heart: validation, regional heterogeneity, and relation to refractoriness.
Journal of cardiovascular electrophysiology 2001;12(11):1286-94.
2001: Björn C Knollmann; James D Potter
Altered regulation of cardiac muscle contraction by troponin T mutations that cause familial hypertrophic cardiomyopathy.
Trends in cardiovascular medicine 2001;11(5):206-12.
2001: Björn C Knollmann; S A Blatt; K Horton; F de Freitas; Todd Miller; M Bell; Philippe R Housmans; N J Weissman; Martin Morad; James D Potter
Inotropic stimulation induces cardiac dysfunction in transgenic mice expressing a troponin T (I79N) mutation linked to familial hypertrophic cardiomyopathy.
The Journal of biological chemistry 2001;276(13):10039-48.
2001: Mathew C Casimiro; Björn C Knollmann; Steven N Ebert; J C Vary; Anne E Greene; M R Franz; Alexander Grinberg; Sing-Ping Huang; Karl Pfeifer
Targeted disruption of the Kcnq1 gene produces a mouse model of Jervell and Lange-Nielsen Syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2526-31.
2000: Björn C Knollmann; B E Knollmann-Ritschel; Neil J Weissman; Larry R Jones; Martin Morad
Remodelling of ionic currents in hypertrophied and failing hearts of transgenic mice overexpressing calsequestrin.
The Journal of physiology 2000;525 Pt 2():483-98.
1998: MD Drici; Björn C Knollmann; WX Wang; Raymond L Woosley
Cardiac actions of erythromycin: influence of female sex.
JAMA : the journal of the American Medical Association 1998;280(20):1774-6.
1998: Steffen Behrens; C Li; Björn C Knollmann; Michael R Franz
Dispersion of ventricular repolarization in the voltage domain.
Pacing and clinical electrophysiology : PACE 1998;21(1 Pt 1):100-7.