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Margaret Knowles

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L E De Faveri; Carolyn D Hurst; Margaret A Knowles; F M Platt; J-A Roulson; M Sanchez-Carbayo; Claire F Taylor; E J Chapman
Putative tumour suppressor gene necdin is hypermethylated and mutated in human cancer.
Boling Qiao; Mark T W Teo; Margaret A Knowles; Roger M Phillips; Robert G Bristow; Blaz Groselj; Martin Kerr; Anne E Kiltie
Imatinib radiosensitizes bladder cancer by targeting homologous recombination.
R L Ross; Jon M Askham; Margaret A Knowles
PIK3CA mutation spectrum in urothelial carcinoma reflects cell context-dependent signaling and phenotypic outputs.

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2013: L E De Faveri; Carolyn D Hurst; Margaret A Knowles; F M Platt; J-A Roulson; M Sanchez-Carbayo; Claire F Taylor; E J Chapman
Putative tumour suppressor gene necdin is hypermethylated and mutated in human cancer.
British journal of cancer 2013;108(6):1368-77.
2013: Boling Qiao; Mark T W Teo; Margaret A Knowles; Roger M Phillips; Robert G Bristow; Blaz Groselj; Martin Kerr; Anne E Kiltie
Imatinib radiosensitizes bladder cancer by targeting homologous recombination.
Cancer research 2013;73(5):1611-20.
2013: R L Ross; Jon M Askham; Margaret A Knowles
PIK3CA mutation spectrum in urothelial carcinoma reflects cell context-dependent signaling and phenotypic outputs.
Oncogene 2013;32(6):768-76.
2012: Carolyn D Hurst; Fiona M Platt; Claire F Taylor; Margaret A Knowles
Novel tumor subgroups of urothelial carcinoma of the bladder defined by integrated genomic analysis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(21):5865-77.
2012: Darren C Tomlinson; Margaret A Knowles; V Speirs
Mechanisms of FGFR3 actions in endocrine resistant breast cancer.
International journal of cancer. Journal international du cancer 2012;130(12):2857-66.
2012: Erica di Martino; Darren C Tomlinson; Margaret A Knowles
A Decade of FGF Receptor Research in Bladder Cancer: Past, Present, and Future Challenges.
Advances in urology 2012;2012():429213.
2012: Darren C Tomlinson; Paul M Loadman; Euan W Baxter; Mark A Hull; Margaret A Knowles
FGFR1-induced epithelial to mesenchymal transition through MAPK/PLCγ/COX-2-mediated mechanisms.
PloS one 2012;7(6):e38972.
2011: Lukas Kurt Josef Stadler; Christian Tiede; Darren Charles Tomlinson; Simon D Wagner; Anil Wipat; Michael Busby; Simon J Cockell; Jason J Davis; Keith Flanagan; Elisenda Gendra; Colin Harwood; Toni Hoffmann; Neil Keegan; Margaret A Knowles; Tracy Lee; Yvonne Nyathi; Qifeng Song; Paul Ko Ferrigno
Structure-function studies of an engineered scaffold protein derived from Stefin A. II: Development and applications of the SQT variant.
Protein engineering, design & selection : PEDS 2011;24(9):751-63.
2011: Boling Qiao; Abdul-Haq Ansari; Gina B Scott; Sei C Sak; Philip A Chambers; Faye Elliott; Mark T W Teo; Johanne Bentley; Michael Churchman; Janet Hall; Claire F Taylor; Timothy D Bishop; Margaret A Knowles; Anne E Kiltie
In vitro functional effects of XPC gene rare variants from bladder cancer patients.
Carcinogenesis 2011;32(4):516-21.
2011: F R Lamont; Darren C Tomlinson; P A Cooper; S D Shnyder; John D Chester; Margaret A Knowles
Small molecule FGF receptor inhibitors block FGFR-dependent urothelial carcinoma growth in vitro and in vivo.
British journal of cancer 2011;104(1):75-82.
2011: Boling Qiao; Gina B Scott; Laurence Vaslin; Margaret A Knowles; Johanne Bentley; D Timothy Bishop; Faye Elliott; Janet Hall; Anne E Kiltie
Functional assays to determine the significance of two common XPC 3'UTR variants found in bladder cancer patients.
BMC medical genetics 2011;12():84.
2010: Darren C Tomlinson; Margaret A Knowles
Altered splicing of FGFR1 is associated with high tumor grade and stage and leads to increased sensitivity to FGF1 in bladder cancer.
The American journal of pathology 2010;177(5):2379-86.
2010: Rosalyn Jewell; Caroline Conway; Angana Mitra; Juliette Randerson-Moor; Samira Lobo; Jérémie Nsengimana; Mark Harland; Maria Marples; Sara Edward; Martin Cook; Barry Powell; Andy Boon; Floor de Kort; Katharine A Parker; Ian Cree; Jennifer H Barrett; Margaret A Knowles; D Timothy Bishop; Julia Newton-Bishop
Patterns of expression of DNA repair genes and relapse from melanoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(21):5211-21.
2010: Ananya Choudhury; Louisa D Nelson; Mark T W Teo; Sameer Chilka; Selina Bhattarai; Colin F Johnston; Faye Elliott; Johanna Lowery; Claire F Taylor; Michael Churchman; Johanne Bentley; Margaret A Knowles; Patricia Harnden; Robert G Bristow; D Timothy Bishop; Anne E Kiltie
MRE11 expression is predictive of cause-specific survival following radical radiotherapy for muscle-invasive bladder cancer.
Cancer research 2010;70(18):7017-26.
2010: Sarah V Williams; Fiona M Platt; Carolyn D Hurst; Jo S Aveyard; Claire F Taylor; Jessica C M Pole; Maria J Garcia; Margaret A Knowles
High-resolution analysis of genomic alteration on chromosome arm 8p in urothelial carcinoma.
Genes, chromosomes & cancer 2010;49(7):642-59.
2010: Caroline Conway; Samantha Beswick; Faye Elliott; Yu-Mei Chang; Juliette A Randerson-Moor; Mark Harland; Paul Affleck; Jerry Marsden; D Scott Sanders; Andy Boon; Margaret A Knowles; D Timothy Bishop; Julia Newton-Bishop
Deletion at chromosome arm 9p in relation to BRAF/NRAS mutations and prognostic significance for primary melanoma.
Genes, chromosomes & cancer 2010;49(5):425-38.
2010: Jon M Askham; F Platt; P A Chambers; H Snowden; Claire F Taylor; Margaret A Knowles
AKT1 mutations in bladder cancer: identification of a novel oncogenic mutation that can co-operate with E17K.
Oncogene 2010;29(1):150-5.
2009: E di Martino; Corine G M L'hôte; Wendy Kennedy; Darren C Tomlinson; Margaret A Knowles
Mutant fibroblast growth factor receptor 3 induces intracellular signaling and cellular transformation in a cell type- and mutation-specific manner.
Oncogene 2009;28(48):4306-16.
2009: Margaret A Knowles; Fiona M Platt; Rebecca L Ross; Carolyn D Hurst
Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancer.
Cancer metastasis reviews 2009;28(3-4):305-16.
2009: Caroline Conway; Angana Mitra; Rosalyn Jewell; Juliette A Randerson-Moor; Samira Lobo; Jérémie Nsengimana; Sara Edward; D Scott Sanders; Martin Cook; Barry Powell; Andy Boon; Faye Elliott; Floor de Kort; Margaret A Knowles; D Timothy Bishop; Julia Newton-Bishop
Gene expression profiling of paraffin-embedded primary melanoma using the DASL assay identifies increased osteopontin expression as predictive of reduced relapse-free survival.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(22):6939-46.
2009: Emma J Chapman; Margaret A Knowles
Necdin: a multi functional protein with potential tumor suppressor role?
Molecular carcinogenesis 2009;48(11):975-81.
2009: Fiona M Platt; Carolyn D Hurst; Claire F Taylor; Walter Gregory; Patricia Harnden; Margaret A Knowles
Spectrum of phosphatidylinositol 3-kinase pathway gene alterations in bladder cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(19):6008-17.
2009: Emma J Chapman; Sarah V Williams; Fiona M Platt; Carolyn D Hurst; Philip Chambers; Paul Roberts; Margaret A Knowles
Integrated genomic and transcriptional analysis of the in vitro evolution of telomerase-immortalized urothelial cells (TERT-NHUC).
Genes, chromosomes & cancer 2009;48(8):694-710.
2009: Darren C Tomlinson; Fiona R Lamont; Steve D Shnyder; Margaret A Knowles
Fibroblast growth factor receptor 1 promotes proliferation and survival via activation of the mitogen-activated protein kinase pathway in bladder cancer.
Cancer research 2009;69(11):4613-20.
2009: Johanne Bentley; Corine L'Hôte; Fiona Platt; Carolyn D Hurst; Johanna Lowery; Claire Taylor; Sei Chung Sak; Patricia Harnden; Margaret A Knowles; Anne E Kiltie
Papillary and muscle invasive bladder tumors with distinct genomic stability profiles have different DNA repair fidelity and KU DNA-binding activities.
Genes, chromosomes & cancer 2009;48(4):310-21.
2009: Carolyn D Hurst; Tahlita C M Zuiverloon; Christian Hafner; Ellen C Zwarthoff; Margaret A Knowles
A SNaPshot assay for the rapid and simple detection of four common hotspot codon mutations in the PIK3CA gene.
BMC research notes 2009;2():66.
2008: Margaret A Knowles
Bladder cancer subtypes defined by genomic alterations.
Scandinavian journal of urology and nephrology. Supplementum 2008;(218):116-30.
2008: Margaret A Knowles
Molecular pathogenesis of bladder cancer.
International journal of clinical oncology 2008;13(4):287-97.
2008: Emma J Chapman; Gavin Kelly; Margaret A Knowles
Genes involved in differentiation, stem cell renewal, and tumorigenesis are modulated in telomerase-immortalized human urothelial cells.
Molecular cancer research : MCR 2008;6(7):1154-68.
2008: Louis S Pymar; Fiona M Platt; Jon M Askham; Ewan E Morrison; Margaret A Knowles
Bladder tumour-derived somatic TSC1 missense mutations cause loss of function via distinct mechanisms.
Human molecular genetics 2008;17(13):2006-17.
2008: Carolyn D Hurst; Darren C Tomlinson; S V Williams; F M Platt; Margaret A Knowles
Inactivation of the Rb pathway and overexpression of both isoforms of E2F3 are obligate events in bladder tumours with 6p22 amplification.
Oncogene 2008;27(19):2716-27.
2007: Darren C Tomlinson; O Baldo; Patricia Harnden; Margaret A Knowles
FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancer.
The Journal of pathology 2007;213(1):91-8.
2007: Darren C Tomlinson; Carolyn D Hurst; Margaret A Knowles
Knockdown by shRNA identifies S249C mutant FGFR3 as a potential therapeutic target in bladder cancer.
Oncogene 2007;26(40):5889-99.
2007: Margaret A Knowles
Tumor suppressor loci in bladder cancer.
Frontiers in bioscience : a journal and virtual library 2007;12():2233-51.
2006: Nicholas P Munro; David A Cairns; Paul Clarke; Mark Rogers; Anthea J Stanley; Jennifer H Barrett; Patricia Harnden; Douglas Thompson; Ian Eardley; Rosamonde E Banks; Margaret A Knowles
Urinary biomarker profiling in transitional cell carcinoma.
International journal of cancer. Journal international du cancer 2006;119(11):2642-50.
2006: E J Chapman; Carolyn D Hurst; Eva Pitt; P Chambers; Joanne S Aveyard; Margaret A Knowles
Expression of hTERT immortalises normal human urothelial cells without inactivation of the p16/Rb pathway.
Oncogene 2006;25(36):5037-45.
2006: Jari Louhelainen; Carolyn D Hurst; Eva Pitt; H Nishiyama; H A Pickett; Margaret A Knowles
DBC1 re-expression alters the expression of multiple components of the plasminogen pathway.
Oncogene 2006;25(16):2409-19.
2006: Margaret A Knowles
Molecular subtypes of bladder cancer: Jekyll and Hyde or chalk and cheese?
Carcinogenesis 2006;27(3):361-73.
2005: Darren C Tomlinson; Corine G M L'hôte; Wendy Kennedy; Eva Pitt; Margaret A Knowles
Alternative splicing of fibroblast growth factor receptor 3 produces a secreted isoform that inhibits fibroblast growth factor-induced proliferation and is repressed in urothelial carcinoma cell lines.
Cancer research 2005;65(22):10441-9.
2005: Sushila H Mistry; Claire Taylor; Juliette A Randerson-Moor; Mark Harland; Faye Turner; Jennifer H Barrett; Linda Whitaker; Robert B Jenkins; Margaret A Knowles; Julia Newton-Bishop; D Timothy Bishop
Prevalence of 9p21 deletions in UK melanoma families.
Genes, chromosomes & cancer 2005;44(3):292-300.
2005: Emma J Chapman; Patricia Harnden; Philip Chambers; Colin Johnston; Margaret A Knowles
Comprehensive analysis of CDKN2A status in microdissected urothelial cell carcinoma reveals potential haploinsufficiency, a high frequency of homozygous co-deletion and associations with clinical phenotype.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(16):5740-7.
2005: Adel H Jebar; Carolyn D Hurst; Darren C Tomlinson; Colin Johnston; Claire F Taylor; Margaret A Knowles
FGFR3 and Ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma.
Oncogene 2005;24(33):5218-25.
2005: Sarah V Williams; Jacqui Adams; Jane Coulter; Brenda Summersgill; Janet Shipley; Margaret A Knowles
Assessment by M-FISH of karyotypic complexity and cytogenetic evolution in bladder cancer in vitro.
Genes, chromosomes & cancer 2005;43(4):315-28.
2005: Margaret A Knowles; Joanne S Aveyard; Claire F Taylor; Patricia Harnden; Sylvia Bass
Mutation analysis of the 8p candidate tumour suppressor genes DBC2 (RHOBTB2) and LZTS1 in bladder cancer.
Cancer letters 2005;225(1):121-30.
2005: Geoffrey D Hall; Robert Weeks; Jonathon Olsburgh; Jennifer Southgate; Margaret A Knowles; Peter J Selby; John D Chester
Transcriptional control of the human urothelial-specific gene, uroplakin Ia.
Biochimica et biophysica acta 2005;1729(2):126-34.
2005: Jacqui Adams; Darren Cuthbert-Heavens; Sylvia Bass; Margaret A Knowles
Infrequent mutation of TRAIL receptor 2 (TRAIL-R2/DR5) in transitional cell carcinoma of the bladder with 8p21 loss of heterozygosity.
Cancer letters 2005;220(2):137-44.
2005: Corine G M L'hôte; Margaret A Knowles
Cell responses to FGFR3 signalling: growth, differentiation and apoptosis.
Experimental cell research 2005;304(2):417-31.
2005: Christine P Diggle; Johanne Bentley; Margaret A Knowles; Anne E Kiltie
Inhibition of double-strand break non-homologous end-joining by cisplatin adducts in human cell extracts.
Nucleic acids research 2005;33(8):2531-9.
2005: Jacqui Adams; Sarah V Williams; Joanne S Aveyard; Margaret A Knowles
Loss of heterozygosity analysis and DNA copy number measurement on 8p in bladder cancer reveals two mechanisms of allelic loss.
Cancer research 2005;65(1):66-75.
2004: Joanne S Aveyard; Margaret A Knowles
Measurement of relative copy number of CDKN2A/ARF and CDKN2B in bladder cancer by real-time quantitative PCR and multiplex ligation-dependent probe amplification.
The Journal of molecular diagnostics : JMD 2004;6(4):356-65.
2004: Carolyn D Hurst; Heike Fiegler; Philippa Carr; Sarah Williams; Nigel P Carter; Margaret A Knowles
High-resolution analysis of genomic copy number alterations in bladder cancer by microarray-based comparative genomic hybridization.
Oncogene 2004;23(12):2250-63.
2004: Johanne Bentley; Christine P Diggle; Patricia Harnden; Margaret A Knowles; Anne E Kiltie
DNA double strand break repair in human bladder cancer is error prone and involves microhomology-associated end-joining.
Nucleic acids research 2004;32(17):5249-59.
2003: Rachael Natrajan; Jari Louhelainen; Sarah Williams; Jonathan Laye; Margaret A Knowles
High-resolution deletion mapping of 15q13.2-q21.1 in transitional cell carcinoma of the bladder.
Cancer research 2003;63(22):7657-62.
2003: Margaret A Knowles; Tomonori Habuchi; Wendy Kennedy; Darren Cuthbert-Heavens
Mutation spectrum of the 9q34 tuberous sclerosis gene TSC1 in transitional cell carcinoma of the bladder.
Cancer research 2003;63(22):7652-6.
2003: Christine P Diggle; Sheena M Cruickshank; Jonathon Olsburgh; Stephanie Pellegrin; Barbara Smith; Rosamonde E Banks; Peter J Selby; Margaret A Knowles; Jennifer Southgate; Patricia Harnden
Identification of genes up-regulated in urothelial tumors: the 67-kd laminin receptor and tumor-associated trypsin inhibitor.
The American journal of pathology 2003;163(2):493-504.
2003: Margaret A Knowles; Nick Hornigold; Eva Pitt
Tuberous sclerosis complex (TSC) gene involvement in sporadic tumours.
Biochemical Society transactions 2003;31(Pt 3):597-602.
2003: Nicholas P Munro; Margaret A Knowles
Fibroblast growth factors and their receptors in transitional cell carcinoma.
The Journal of urology 2003;169(2):675-82.
2003: John D Chester; Wendy Kennedy; Geoffrey D Hall; Peter J Selby; Margaret A Knowles
Adenovirus-mediated gene therapy for bladder cancer: efficient gene delivery to normal and malignant human urothelial cells in vitro and ex vivo.
Gene therapy 2003;10(2):172-9.
2002: Sarah V Williams; Kathryn D Sibley; Alison M Davies; Hiroyuki Nishiyama; Nick Hornigold; Jane Coulter; Wendy J Kennedy; Amy Skilleter; Tomonori Habuchi; Margaret A Knowles
Molecular genetic analysis of chromosome 9 candidate tumor-suppressor loci in bladder cancer cell lines.
Genes, chromosomes & cancer 2002;34(1):86-96.
2001: Fumihiro Kimura; Andrea R Florl; Hans-Helge Seifert; Jari Louhelainen; Simone Maas; Margaret A Knowles; Wolfgang A Schulz
Destabilization of chromosome 9 in transitional cell carcinoma of the urinary bladder.
British journal of cancer 2001;85(12):1887-93.
2001: Kathryn D Sibley; Peter L Stern; Margaret A Knowles
Frequency of fibroblast growth factor receptor 3 mutations in sporadic tumours.
Oncogene 2001;20(32):4416-8.
2001: H Nishiyama; J H Gill; Eva Pitt; Wendy Kennedy; Margaret A Knowles
Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1.
Oncogene 2001;20(23):2956-64.
2001: Kathryn D Sibley; Darren Cuthbert-Heavens; Margaret A Knowles
Loss of heterozygosity at 4p16.3 and mutation of FGFR3 in transitional cell carcinoma.
Oncogene 2001;20(6):686-91.
2000: Kathryn D Sibley; S Bell; Margaret A Knowles
Redefining a critical region of LOH on 4p16.3 in bladder cancer.
Genes, chromosomes & cancer 2000;29(4):378-9.
2000: Carol Salem; Gangning Liang; Yvonne C Tsai; Jane Coulter; Margaret A Knowles; An-Chen Feng; Susan Groshen; Peter W Nichols; Peter A Jones
Progressive increases in de novo methylation of CpG islands in bladder cancer.
Cancer research 2000;60(9):2473-6.
1999: Richard D Unwin; Margaret A Knowles; Peter J Selby; Rosamonde E Banks
Urological malignancies and the proteomic-genomic interface.
Electrophoresis 1999;20(18):3629-37.
1999: Hiroyuki Nishiyama; T Takahashi; Y Kakehi; Tomonori Habuchi; Margaret A Knowles
Homozygous deletion at the 9q32-33 candidate tumor suppressor locus in primary human bladder cancer.
Genes, chromosomes & cancer 1999;26(2):171-5.
1999: Margaret A Knowles
The genetics of transitional cell carcinoma: progress and potential clinical application.
BJU international 1999;84(4):412-27.
1999: Hiroyuki Nishiyama; Nick Hornigold; Alison M Davies; Margaret A Knowles
A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33.
Genomics 1999;59(3):335-8.
1999: Joanne S Aveyard; A Skilleter; T Habuchi; Margaret A Knowles
Somatic mutation of PTEN in bladder carcinoma.
British journal of cancer 1999;80(5-6):904-8.
1999: Nick Hornigold; J Devlin; Alison M Davies; Joanne S Aveyard; Tomonori Habuchi; Margaret A Knowles
Mutation of the 9q34 gene TSC1 in sporadic bladder cancer.
Oncogene 1999;18(16):2657-61.
1999: Margaret A Knowles
Identification of novel bladder tumour suppressor genes.
Electrophoresis 1999;20(2):269-79.
1998: Margaret A Knowles
Molecular genetics of bladder cancer: pathways of development and progression.
Cancer surveys 1998;31():49-76.
1997: S M Bell; M Shaw; Y S Jou; Richard Myers; Margaret A Knowles
Identification and characterization of the human homologue of SH3BP2, an SH3 binding domain protein within a common region of deletion at 4p16.3 involved in bladder cancer.
Genomics 1997;44(2):163-70.
1997: M E Eydmann; Margaret A Knowles
Mutation analysis of 8p genes POLB and PPP2CB in bladder cancer.
Cancer genetics and cytogenetics 1997;93(2):167-71.
1996: S M Bell; J Zuo; Richard Myers; Margaret A Knowles
Fluorescence in situ hybridization deletion mapping at 4p16.3 in bladder cancer cell lines refines the localisation of the critical interval to 30 kb.
Genes, chromosomes & cancer 1996;17(2):108-17.
1996: L A Takle; Margaret A Knowles
Deletion mapping implicates two tumor suppressor genes on chromosome 8p in the development of bladder cancer.
Oncogene 1996;12(5):1083-7.
1996: J Devlin; P A Elder; H Gabra; Michael Steel; Margaret A Knowles
High frequency of chromosome 9 deletion in ovarian cancer: evidence for three tumour-suppressor loci.
British journal of cancer 1996;73(4):420-3.
1995: T Habuchi; J Devlin; P A Elder; Margaret A Knowles
Detailed deletion mapping of chromosome 9q in bladder cancer: evidence for two tumour suppressor loci.
Oncogene 1995;11(8):1671-4.
1995: M P Williamson; P A Elder; M E Shaw; J Devlin; Margaret A Knowles
p16 (CDKN2) is a major deletion target at 9p21 in bladder cancer.
Human molecular genetics 1995;4(9):1569-77.
1995: Margaret A Knowles
Molecular genetics of bladder cancer.
British journal of urology 1995;75 Suppl 1():57-66.
1995: M E Shaw; Margaret A Knowles
Deletion mapping of chromosome 11 in carcinoma of the bladder.
Genes, chromosomes & cancer 1995;13(1):1-8.
1994: P A Elder; S M Bell; Margaret A Knowles
Deletion of two regions on chromosome 4 in bladder carcinoma: definition of a critical 750kB region at 4p16.3.
Oncogene 1994;9(12):3433-6.
1994: J Devlin; A J Keen; Margaret A Knowles
Homozygous deletion mapping at 9p21 in bladder carcinoma defines a critical region within 2cM of IFNA.
Oncogene 1994;9(9):2757-60.
1994: A J Keen; Margaret A Knowles
Definition of two regions of deletion on chromosome 9 in carcinoma of the bladder.
Oncogene 1994;9(7):2083-8.
1994: M P Williamson; P A Elder; Margaret A Knowles
The spectrum of TP53 mutations in bladder carcinoma.
Genes, chromosomes & cancer 1994;9(2):108-18.
1994: Margaret A Knowles; P A Elder; M Williamson; J P Cairns; M E Shaw; M G Law
Allelotype of human bladder cancer.
Cancer research 1994;54(2):531-8.
1993: Margaret A Knowles; M E Shaw; A J Proctor
Deletion mapping of chromosome 8 in cancers of the urinary bladder using restriction fragment length polymorphisms and microsatellite polymorphisms.
Oncogene 1993;8(5):1357-64.
1993: P Cairns; M E Shaw; Margaret A Knowles
Initiation of bladder cancer may involve deletion of a tumour-suppressor gene on chromosome 9.
Oncogene 1993;8(4):1083-5.
1993: P Cairns; M E Shaw; Margaret A Knowles
Preliminary mapping of the deleted region of chromosome 9 in bladder cancer.
Cancer research 1993;53(6):1230-2.
1993: H J Xu; P Cairns; S X Hu; Margaret A Knowles; W F Benedict
Loss of RB protein expression in primary bladder cancer correlates with loss of heterozygosity at the RB locus and tumor progression.
International journal of cancer. Journal international du cancer 1993;53(5):781-4.
1993: L M Coombs; D A Pigott; M E Eydmann; A J Proctor; Margaret A Knowles
Reduced expression of TGF beta is associated with advanced disease in transitional cell carcinoma.
British journal of cancer 1993;67(3):578-84.
1993: Margaret A Knowles; M Williamson
Mutation of H-ras is infrequent in bladder cancer: confirmation by single-strand conformation polymorphism analysis, designed restriction fragment length polymorphisms, and direct sequencing.
Cancer research 1993;53(1):133-9.
1991: P Cairns; A J Proctor; Margaret A Knowles
Loss of heterozygosity at the RB locus is frequent and correlates with muscle invasion in bladder carcinoma.
Oncogene 1991;6(12):2305-9.
1991: A J Proctor; L M Coombs; J P Cairns; Margaret A Knowles
Amplification at chromosome 11q13 in transitional cell tumours of the bladder.
Oncogene 1991;6(5):789-95.
1991: L M Coombs; D A Pigott; E Sweeney; A J Proctor; M E Eydmann; C Parkinson; Margaret A Knowles
Amplification and over-expression of c-erbB-2 in transitional cell carcinoma of the urinary bladder.
British journal of cancer 1991;63(4):601-8.
1991: Margaret A Knowles; M E Eydmann
Loss of a tumor suppressor function during neoplastic progression of epithelial cells in vitro.
International journal of cancer. Journal international du cancer 1991;47(5):726-31.
1990: L M Coombs; D Pigott; A Proctor; M Eydmann; J Denner; Margaret A Knowles
Simultaneous isolation of DNA, RNA, and antigenic protein exhibiting kinase activity from small tumor samples using guanidine isothiocyanate.
Analytical biochemistry 1990;188(2):338-43.
1987: Margaret A Knowles; M E Eydmann; A Proctor; R A Padua; J Roberts
N-methyl-N-nitrosourea-induced transformation of rat urothelial cells in vitro is not mediated by activation of ras oncogenes.
Oncogene 1987;1(2):143-8.