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Tuomas Knowles

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Li-Qiong Xu; Hong Zhang; Mark E Welland; Si Wu; Alexander K Buell; Li-Jun Chen; Samuel I A Cohen; Sarah A Cusack; Christopher M Dobson; Wan-Hui Hu; Laura S Itzhaki; Gary W Jones; Tuomas P J Knowles; Sarah Perrett
Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2.
Anthony Fitzpatrick; Robert G Griffin; Christopher Jaroniec; Tuomas P J Knowles; Vladimir Ladizhansky; Cait E MacPhee; Helen R Mott; Shirley A Müller; Elena V Orlova; Helen R Saibil; Michele Vendruscolo; Luchun Wang; Christopher Waudby; Vikram S Bajaj; Marvin J Bayro; Marc A Caporini; Daniel K Clare; Alfonso De Simone; Galia T Debelouchina; Christopher M Dobson
Atomic structure and hierarchical assembly of a cross-β amyloid fibril.
Alexander K Buell; Christopher M Dobson; Peter Hung; Xavier Salvatella; Mark E Welland; Tuomas P J Knowles
Electrostatic effects in filamentous protein aggregation.

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All Publications

2013: Li-Qiong Xu; Hong Zhang; Mark E Welland; Si Wu; Alexander K Buell; Li-Jun Chen; Samuel I A Cohen; Sarah A Cusack; Christopher M Dobson; Wan-Hui Hu; Laura S Itzhaki; Gary W Jones; Tuomas P J Knowles; Sarah Perrett
Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2013;368(1617):20110410.
2013: Anthony Fitzpatrick; Robert G Griffin; Christopher Jaroniec; Tuomas P J Knowles; Vladimir Ladizhansky; Cait E MacPhee; Helen R Mott; Shirley A Müller; Elena V Orlova; Helen R Saibil; Michele Vendruscolo; Luchun Wang; Christopher Waudby; Vikram S Bajaj; Marvin J Bayro; Marc A Caporini; Daniel K Clare; Alfonso De Simone; Galia T Debelouchina; Christopher M Dobson
Atomic structure and hierarchical assembly of a cross-β amyloid fibril.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(14):5468-73.
2013: Alexander K Buell; Christopher M Dobson; Peter Hung; Xavier Salvatella; Mark E Welland; Tuomas P J Knowles
Electrostatic effects in filamentous protein aggregation.
Biophysical journal 2013;104(5):1116-26.
2013: Maral Yolamanova; Onofrio Zirafi; Franziska Arnold; Carlos W Bertoncini; Jens Bohne; Wolf-Georg Forssmann; Hartmut Geiger; Christine Goffinet; Pavel G Khalatur; Alexei R Khokhlov; Frank Kirchhoff; Tuomas P J Knowles; Oleg Lunov; Christoph Meier; Janis A Müller; David Palesch; Nadia R Roan; Xavier Salvatella; Daniel Sauter; Hubert Schrezenmeier; Klaus Schwarz; Alexey K Shaytan; Thomas Simmet; Ludger Ständker; Shariq M Usmani; Virag Vas; Paul Walther; Tanja Weil; Jan Münch
Peptide nanofibrils boost retroviral gene transfer and provide a rapid means for concentrating viruses.
Nature nanotechnology 2013;8(2):130-6.
2012: Tuomas P J Knowles; Sarah Meehan; Luke Rajah; Andrew Baldwin; Alfonso De Simone; Christopher M Dobson; Anthony Fitzpatrick; Michele Vendruscolo; Mark E Welland; Eugene M Terentjev
Twisting transition between crystalline and fibrillar phases of aggregated peptides.
Physical review letters 2012;109(15):158101.
2012: Samuel I A Cohen; Christopher M Dobson; Michele Vendruscolo; Tuomas P J Knowles
From macroscopic measurements to microscopic mechanisms of protein aggregation.
Journal of molecular biology 2012;421(2-3):160-71.
2012: Eva K McGuire; Michael Motskin; Jeremy N Skepper; Shane D Bergin; Benedetta Bolognesi; Christopher M Dobson; Tuomas P J Knowles; Leila M Luheshi; David W McComb; Alexandra E Porter
Selenium-enhanced electron microscopic imaging of different aggregate forms of a segment of the amyloid β peptide in cells.
ACS nano 2012;6(6):4740-7.
2012: Nunilo Cremades; Emma Deas; Christopher M Dobson; Paul Dunne; Andrey Y Abramov; Francesco A Aprile; CARLOS WALTER BERTONCINI; Allen Y Chen; Richard W Clarke; Samuel I A Cohen; Tuomas P J Knowles; Angel Orte; Massimo Sandal; Nicholas W Wood; David Klenerman
Direct observation of the interconversion of normal and toxic forms of α-synuclein.
Cell 2012;149(5):1048-59.
2012: Alexander K Buell; Anne Dhulesia; Christopher M Dobson; Tuomas P J Knowles; Duncan A White; Mark E Welland
Detailed analysis of the energy barriers for amyloid fibril growth.
Angewandte Chemie (International ed. in English) 2012;51(21):5247-51.
2012: Nikolai Lorenzen; Søren B Nielsen; Gunna Christiansen; Samuel I A Cohen; Christopher M Dobson; Therese W Herling; Tuomas P J Knowles; Daniel E Otzen
Role of elongation and secondary pathways in S6 amyloid fibril growth.
Biophysical journal 2012;102(9):2167-75.
2012: Noah S Bieler; Daan Frenkel; Tuomas P J Knowles; Robert Vácha
Connecting macroscopic observables and microscopic assembly events in amyloid formation using coarse grained simulations.
PLoS computational biology 2012;8(10):e1002692.
2011: Alexander K Buell; Christopher M Dobson; Elin K Esbjörner; Patrick J Riss; Gergely Toth; Mark E Welland; Duncan A White; Franklin I Aigbirhio; Tuomas P J Knowles
Probing small molecule binding to amyloid fibrils.
Physical chemistry chemical physics : PCCP 2011;13(45):20044-52.
2011: Michele Vendruscolo; Tuomas P J Knowles; Christopher M Dobson
Protein solubility and protein homeostasis: a generic view of protein misfolding disorders.
Cold Spring Harbor perspectives in biology 2011;3(12):.
2011: Sarah L Shammas; Shuyu Wang; Christopher Waudby; Mark E Welland; Alexander K Buell; John A Carver; Christopher M Dobson; Heath Ecroyd; Tuomas P J Knowles; Sarah Meehan
Binding of the molecular chaperone αB-crystallin to Aβ amyloid fibrils inhibits fibril elongation.
Biophysical journal 2011;101(7):1681-9.
2011: Anthony Fitzpatrick; Tuomas P J Knowles; Michele Vendruscolo; Christopher Waudby; Christopher M Dobson
Inversion of the balance between hydrophobic and hydrogen bonding interactions in protein folding and aggregation.
PLoS computational biology 2011;7(10):e1002169.
2011: Andrew Baldwin; Paul D Barker; John Christodoulou; Glyn L Devlin; Spencer J Anthony-Cahill; Anthony Fitzpatrick; Sally L Gras; Tuomas P J Knowles; Sarah Meehan; Maria F Mossuto; Sarah Lucy Shammas; Gian Gaetano Tartaglia; Michele Vendruscolo; Christopher Waudby; Christopher M Dobson
Metastability of native proteins and the phenomenon of amyloid formation.
Journal of the American Chemical Society 2011;133(36):14160-3.
2011: Tuomas P J Knowles; Ralph A Sperling; Duncan A White; Adam R Abate; Jeremy J Agresti; Samuel I A Cohen; Erwin J De Genst; Christopher M Dobson; David A Weitz
Observation of spatial propagation of amyloid assembly from single nuclei.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(36):14746-51.
2011: Samuel I A Cohen; Christopher M Dobson; Michele Vendruscolo; Tuomas P J Knowles
Nucleated polymerization with secondary pathways. III. Equilibrium behavior and oligomer populations.
The Journal of chemical physics 2011;135(6):065107.
2011: Samuel I A Cohen; Christopher M Dobson; Michele Vendruscolo; Tuomas P J Knowles
Nucleated polymerization with secondary pathways. II. Determination of self-consistent solutions to growth processes described by non-linear master equations.
The Journal of chemical physics 2011;135(6):065106.
2011: Samuel I A Cohen; Christopher M Dobson; Eugene M Terentjev; Michele Vendruscolo; Mark E Welland; Tuomas P J Knowles
Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments.
The Journal of chemical physics 2011;135(6):065105.
2011: Katerina Levitan; John P Anderson; David Chereau; Samuel I A Cohen; Christopher M Dobson; Anthony L Fink; Jason M Goldstein; Tuomas P J Knowles; Glenn L Millhauser
Conserved C-terminal charge exerts a profound influence on the aggregation rate of α-synuclein.
Journal of molecular biology 2011;411(2):329-33.
2011: Tuomas P J Knowles; Markus J Buehler
Nanomechanics of functional and pathological amyloid materials.
Nature nanotechnology 2011;6(8):469-79.
2011: Sarah L Shammas; Tuomas P J Knowles; Andrew Baldwin; Cait E MacPhee; Mark E Welland; Christopher M Dobson; Glyn L Devlin
Perturbation of the stability of amyloid fibrils through alteration of electrostatic interactions.
Biophysical journal 2011;100(11):2783-91.
2011: Alexander K Buell; Anne Dhulesia; Maria F Mossuto; Nunilo Cremades; Janet R Kumita; Mireille Dumoulin; Mark E Welland; Tuomas P J Knowles; Xavier Salvatella; Christopher M Dobson
Population of nonnative states of lysozyme variants drives amyloid fibril formation.
Journal of the American Chemical Society 2011;133(20):7737-43.
2011: Yi-Qian Wang; Alexander K Buell; Xin-Yu Wang; Mark E Welland; Christopher M Dobson; Tuomas P J Knowles; Sarah Perrett
Relationship between prion propensity and the rates of individual molecular steps of fibril assembly.
The Journal of biological chemistry 2011;286(14):12101-7.
2011: Samuel I A Cohen; Christopher M Dobson; Michele Vendruscolo; Tuomas P J Knowles
Nucleated polymerisation in the presence of pre-formed seed filaments.
International journal of molecular sciences 2011;12(9):5844-52.
2011: Tuomas P J Knowles; Glyn L Devlin; Christopher M Dobson; Mark E Welland
Probing protein aggregation with quartz crystal microbalances.
Methods in molecular biology (Clifton, N.J.) 2011;752():137-45.
2010: Alexander K Buell; Christopher M Dobson; Tuomas P J Knowles; Mark E Welland
Interactions between amyloidophilic dyes and their relevance to studies of amyloid inhibitors.
Biophysical journal 2010;99(10):3492-7.
2010: Alexander K Buell; Duncan A White; Christoph Meier; Mark E Welland; Tuomas P J Knowles; Christopher M Dobson
Surface attachment of protein fibrils via covalent modification strategies.
The journal of physical chemistry. B 2010;114(34):10925-38.
2010: Anders Sandberg; Leila M Luheshi; Sofia Söllvander; Teresa Pereira de Barros; Bertil Macao; Tuomas P J Knowles; Henrik Biverstål; Christofer Lendel; Frida Ekholm-Petterson; Anatoly Dubnovitsky; Lars Lannfelt; Christopher M Dobson; Torleif Härd
Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(35):15595-600.
2010: Alexander K Buell; Jamie R Blundell; Christopher M Dobson; Mark E Welland; Eugene M Terentjev; Tuomas P J Knowles
Frequency factors in a landscape model of filamentous protein aggregation.
Physical review letters 2010;104(22):228101.
2010: Duncan A White; Alexander K Buell; Tuomas P J Knowles; Mark E Welland; Christopher M Dobson
Protein aggregation in crowded environments.
Journal of the American Chemical Society 2010;132(14):5170-5.
2010: Tomas Oppenheim; Tuomas P J Knowles; Stéphanie P Lacour; Mark E Welland
Fabrication and characterisation of protein fibril-elastomer composites.
Acta biomaterialia 2010;6(4):1337-41.
2010: Christopher Waudby; Tuomas P J Knowles; Glyn L Devlin; Jeremy N Skepper; Heath Ecroyd; John A Carver; Mark E Welland; John Christodoulou; Christopher M Dobson; Sarah Meehan
The interaction of alphaB-crystallin with mature alpha-synuclein amyloid fibrils inhibits their elongation.
Biophysical journal 2010;98(5):843-51.
2010: Tuomas P J Knowles; Tomas W Oppenheim; Alexander K Buell; Dimitri Y Chirgadze; Mark E Welland
Nanostructured films from hierarchical self-assembly of amyloidogenic proteins.
Nature nanotechnology 2010;5(3):204-7.
2010: Ann-Christin Brorsson; Janet R Kumita; Ian MacLeod; Benedetta Bolognesi; Elena Speretta; Leila M Luheshi; Tuomas P J Knowles; Christopher M Dobson; Damian C Crowther
Methods and models in neurodegenerative and systemic protein aggregation diseases.
Frontiers in bioscience : a journal and virtual library 2010;15():373-96.
2009: Tuomas P J Knowles; Christopher Waudby; Glyn L Devlin; Samuel I A Cohen; Adriano Aguzzi; Michele Vendruscolo; Eugene M Terentjev; Mark E Welland; Christopher M Dobson
An analytical solution to the kinetics of breakable filament assembly.
Science (New York, N.Y.) 2009;326(5959):1533-7.
2009: Alexandra E Porter; Tuomas P J Knowles; Karin Muller; Sarah Meehan; Eva McGuire; Jeremy N Skepper; Mark E Welland; Christopher M Dobson
Imaging amyloid fibrils within cells using a Se-labelling strategy.
Journal of molecular biology 2009;392(4):868-71.
2009: Duncan A White; Alexander K Buell; Christopher M Dobson; Mark E Welland; Tuomas P J Knowles
Biosensor-based label-free assays of amyloid growth.
FEBS letters 2009;583(16):2587-92.
2009: Alexander K Buell; Gian Gaetano Tartaglia; Neil R Birkett; Christopher Waudby; Michele Vendruscolo; Xavier Salvatella; Mark E Welland; Christopher M Dobson; Tuomas P J Knowles
Position-dependent electrostatic protection against protein aggregation.
Chembiochem : a European journal of chemical biology 2009;10(8):1309-12.
2008: Jeppe Falsig; K Peterr Nilsson; Tuomas P J Knowles; Adriano Aguzzi
Chemical and biophysical insights into the propagation of prion strains.
HFSP journal 2008;2(6):332-41.
2008: Wenmiao Shu; Sophie Laurenson; Tuomas P J Knowles; Paul Ko Ferrigno; Ashwin A Seshia
Highly specific label-free protein detection from lysed cells using internally referenced microcantilever sensors.
Biosensors & bioelectronics 2008;24(2):233-7.
2008: Tuomas P J Knowles; Hans Peter Lang; Wenmiao Shu; Christopher M Dobson; Christoph Gerber; François Huber; Mark E Welland
Label-free detection of amyloid growth with microcantilever sensors.
Nanotechnology 2008;19(38):384007.
2008: Andrew Baldwin; Spencer J Anthony-Cahill; Tuomas P J Knowles; Guy Lippens; John Christodoulou; Paul D Barker; Christopher M Dobson
Measurement of amyloid fibril length distributions by inclusion of rotational motion in solution NMR diffusion measurements.
Angewandte Chemie (International ed. in English) 2008;47(18):3385-7.
2007: Tuomas P J Knowles; Anthony Fitzpatrick; Sarah Meehan; Helen R Mott; Michele Vendruscolo; Christopher M Dobson; Mark E Welland
Role of intermolecular forces in defining material properties of protein nanofibrils.
Science (New York, N.Y.) 2007;318(5858):1900-3.
2007: Sarah Meehan; Tuomas P J Knowles; Andrew Baldwin; Jeffrey F Smith; Adam M Squires; Phillip Clements; Teresa M Treweek; Heath Ecroyd; Gian Gaetano Tartaglia; Michele Vendruscolo; Cait E MacPhee; Christopher M Dobson; John A Carver
Characterisation of amyloid fibril formation by small heat-shock chaperone proteins human alphaA-, alphaB- and R120G alphaB-crystallins.
Journal of molecular biology 2007;372(2):470-84.
2007: Tuomas P J Knowles; Wenmiao Shu; Glyn L Devlin; Sarah Meehan; Stefan Auer; Christopher M Dobson; Mark E Welland
Kinetics and thermodynamics of amyloid formation from direct measurements of fluctuations in fibril mass.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(24):10016-21.
2006: Jeffrey F Smith; Tuomas P J Knowles; Christopher M Dobson; Cait E MacPhee; Mark E Welland
Characterization of the nanoscale properties of individual amyloid fibrils.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(43):15806-11.
2006: Tuomas P J Knowles; Ralph Zahn
Enhanced stability of human prion proteins with two disulfide bridges.
Biophysical journal 2006;91(4):1494-500.
2006: Glyn L Devlin; Tuomas P J Knowles; Adam M Squires; Margaret McCammon; Sally L Gras; Melanie R Nilsson; Carol V Robinson; Christopher M Dobson; Cait E MacPhee
The component polypeptide chains of bovine insulin nucleate or inhibit aggregation of the parent protein in a conformation-dependent manner.
Journal of molecular biology 2006;360(2):497-509.
2006: Tuomas P J Knowles; Jeffrey F Smith; Aidan Craig; Christopher M Dobson; Mark E Welland
Spatial persistence of angular correlations in amyloid fibrils.
Physical review letters 2006;96(23):238301.