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Erik Knudsen

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Chellappagounder Thangavel; Agnieszka Witkiewicz; Meng Lim; Sankar Addya; Ettickan Boopathi; Adam Ertel; Paolo Fortina; Erik S Knudsen
Regulation of miR106b cluster through the RB pathway: mechanism and functional targets.
Erik S Knudsen; A Kathleen McClendon; Thomas F Pajak; Maria Qeenan; Gordon F Schwartz; Benjamin D Armon; Agnieszka K Witkiewicz
Retinoblastoma and phosphate and tensin homolog tumor suppressors: impact on ductal carcinoma in situ progression.
Agnieszka K Witkiewicz; Adam Ertel; Jeanne McFalls; Gordon Schwartz; Matias E Valsecchi; Erik S Knudsen
RB-pathway disruption is associated with improved response to neoadjuvant chemotherapy in breast cancer.

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All Publications

2013: Chellappagounder Thangavel; Agnieszka Witkiewicz; Meng Lim; Sankar Addya; Ettickan Boopathi; Adam Ertel; Paolo Fortina; Erik S Knudsen
Regulation of miR106b cluster through the RB pathway: mechanism and functional targets.
Cell cycle (Georgetown, Tex.) 2013;12(1):98-111.
2012: Erik S Knudsen; A Kathleen McClendon; Thomas F Pajak; Maria Qeenan; Gordon F Schwartz; Benjamin D Armon; Agnieszka K Witkiewicz
Retinoblastoma and phosphate and tensin homolog tumor suppressors: impact on ductal carcinoma in situ progression.
Journal of the National Cancer Institute 2012;104(23):1825-36.
2012: Agnieszka K Witkiewicz; Adam Ertel; Jeanne McFalls; Gordon Schwartz; Matias E Valsecchi; Erik S Knudsen
RB-pathway disruption is associated with improved response to neoadjuvant chemotherapy in breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(18):5110-22.
2012: Jeffry L Dean; A Kathleen McClendon; Erik S Knudsen
Modification of the DNA damage response by therapeutic CDK4/6 inhibition.
The Journal of biological chemistry 2012;287(34):29075-87.
2012: Jeffry L Dean; Theresa E Hickey; A Kathleen McClendon; Wayne D Tilley; Agnieszka Witkiewicz; Lisa M Butler; Erik S Knudsen
Therapeutic response to CDK4/6 inhibition in breast cancer defined by ex vivo analyses of human tumors.
Cell cycle (Georgetown, Tex.) 2012;11(14):2756-61.
2012: A Kathleen McClendon; Christopher A Reed; Dayana B Rivadeneira; Justine E Yu; Jeffry L Dean; John L Farber; Thomas Force; Erhe Gao; Walter J Koch; Erik S Knudsen
CDK4/6 inhibition antagonizes the cytotoxic response to anthracycline therapy.
Cell cycle (Georgetown, Tex.) 2012;11(14):2747-55.
2012: Erik S Knudsen; Gordon F Schwartz; Elai Davicioni; Adam Ertel; Jessica Kline; Agnieszka K Witkiewicz
Progression of ductal carcinoma in situ to invasive breast cancer is associated with gene expression programs of EMT and myoepithelia.
Breast cancer research and treatment 2012;133(3):1009-24.
2011: Jessica DelBove; Erik S Knudsen; Gary Rosson; Matthew W Strobeck; Weidong Wang; Trevor K Archer; Jianguang Chen; Bernard E Weissman
Identification of a core member of the SWI/SNF complex, BAF155/SMARCC1, as a human tumor suppressor gene.
Epigenetics : official journal of the DNA Methylation Society 2011;6(12):1444-53.
2011: A Kathleen McClendon; Christopher A Reed; Dayana B Rivadeneira; Agnieszka Witkiewicz; Christopher N Mayhew; Sankar Addya; Ryan J Bourgo; Jeffry L Dean; Adam Ertel; Paolo Fortina; Zhiyan Fu; H Leighton Grimes; Erik S Knudsen
RB and p53 cooperate to prevent liver tumorigenesis in response to tissue damage.
Gastroenterology 2011;141(4):1439-50.
2011: Agnieszka Witkiewicz; Dayana B Rivadeneira; Gordon F Schwartz; Adam Ertel; Paolo Fortina; Terry Hyslop; Jessica Kline; Erik S Knudsen
Association of RB/p16-pathway perturbations with DCIS recurrence: dependence on tumor versus tissue microenvironment.
The American journal of pathology 2011;179(3):1171-8.
2011: Ryan J Bourgo; Adam Ertel; Jacqueline Bergseid; A Kathleen McClendon; Chellappagounder Thangavel; Jean Y J Wang; Ludwig Wilkens; Agnieszka Witkiewicz; Erik S Knudsen
RB restricts DNA damage-initiated tumorigenesis through an LXCXE-dependent mechanism of transcriptional control.
Molecular cell 2011;43(4):663-72.
2011: Agnieszka Witkiewicz; Karen E Knudsen; Adam P Dicker; Erik S Knudsen
The meaning of p16(ink4a) expression in tumors: functional significance, clinical associations and future developments.
Cell cycle (Georgetown, Tex.) 2011;10(15):2497-503.
2011: Chellappagounder Thangavel; Jeffry L Dean; Adam Ertel; Karen E Knudsen; C Marcelo Aldaz; Agnieszka K Witkiewicz; Robert Clarke; Erik S Knudsen
Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer.
Endocrine-related cancer 2011;18(3):333-45.
2011: Agnieszka Witkiewicz; Erik S Knudsen
RB pathway and therapeutic sensitivity: new insights in breast cancer and Tamoxifen therapy.
Cell cycle (Georgetown, Tex.) 2011;10(10):1525.
2011: Ubaldo E Martinez-Outschoorn; Marco Prisco; Adam Ertel; Aristotelis Tsirigos; Zhao Lin; Stephanos Pavlides; Chengwang Wang; Neal Flomenberg; Erik S Knudsen; Anthony Howell; Richard G Pestell; Federica Sotgia; Michael P Lisanti
Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics.
Cell cycle (Georgetown, Tex.) 2011;10(8):1271-86.
2011: Ryan J Bourgo; Ursula Ehmer; Julien Sage; Erik S Knudsen
RB deletion disrupts coordination between DNA replication licensing and mitotic entry in vivo.
Molecular biology of the cell 2011;22(7):931-9.
2010: Ankur Sharma; Wen-Shuz Yeow; Adam Ertel; Ilsa Coleman; Nigel Clegg; Chellappagounder Thangavel; Colm Morrissey; Xiaotun Zhang; Clay E S Comstock; Agnieszka K Witkiewicz; Leonard Gomella; Erik S Knudsen; Peter S Nelson; Karen E Knudsen
The retinoblastoma tumor suppressor controls androgen signaling and human prostate cancer progression.
The Journal of clinical investigation 2010;120(12):4478-92.
2010: Adam Ertel; Jeffry L Dean; Hallgeir Rui; Chengbao Liu; Agnieszka Witkiewicz; Karen E Knudsen; Erik S Knudsen
RB-pathway disruption in breast cancer: differential association with disease subtypes, disease-specific prognosis and therapeutic response.
Cell cycle (Georgetown, Tex.) 2010;9(20):4153-63.
2010: Ubaldo E Martinez-Outschoorn; Renee M Balliet; Dayana B Rivadeneira; Barbara Chiavarina; Stephanos Pavlides; Chenguang Wang; Diana Whitaker-Menezes; Kristin M Daumer; Zhao Lin; Agnieszka Witkiewicz; Neal Flomenberg; Anthony Howell; Richard G Pestell; Erik S Knudsen; Federica Sotgia; Michael P Lisanti
Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells.
Cell cycle (Georgetown, Tex.) 2010;9(16):3256-76.
2010: J L Dean; Chellappagounder Thangavel; A Kathleen McClendon; C A Reed; Erik S Knudsen
Therapeutic CDK4/6 inhibition in breast cancer: key mechanisms of response and failure.
Oncogene 2010;29(28):4018-32.
2010: Dayana B Rivadeneira; Christopher N Mayhew; Chellappagounder Thangavel; Elena Sotillo; Christopher A Reed; Xavier Graña; Erik S Knudsen
Proliferative suppression by CDK4/6 inhibition: complex function of the retinoblastoma pathway in liver tissue and hepatoma cells.
Gastroenterology 2010;138(5):1920-30.
2010: Deborah L Burkhart; Lynn K Ngai; Caitlin M Roake; Patrick Viatour; Chellappagounder Thangavel; Victoria M Ho; Erik S Knudsen; Julien Sage
Regulation of RB transcription in vivo by RB family members.
Molecular and cellular biology 2010;30(7):1729-45.
2010: Yasumichi Kuwahara; Aubri Charboneau; Erik S Knudsen; Bernard E Weissman
Reexpression of hSNF5 in malignant rhabdoid tumor cell lines causes cell cycle arrest through a p21(CIP1/WAF1)-dependent mechanism.
Cancer research 2010;70(5):1854-65.
2010: Erik S Knudsen; Jean Y J Wang
Targeting the RB-pathway in cancer therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(4):1094-9.
2010: Christopher A Reed; Christopher N Mayhew; A Kathleen McClendon; Erik S Knudsen
Unique impact of RB loss on hepatic proliferation: tumorigenic stresses uncover distinct pathways of cell cycle control.
The Journal of biological chemistry 2010;285(2):1089-96.
2010: J L Dean; A K McClendon; K R Stengel; Erik S Knudsen
Modeling the effect of the RB tumor suppressor on disease progression: dependence on oncogene network and cellular context.
Oncogene 2010;29(1):68-80.
2010: A Kathleen McClendon; Jeffry L Dean; Adam Ertel; Erik S Knudsen
Differential impact of tumor suppressor pathways on DNA damage response and therapy-induced transformation in a mouse primary cell model.
PloS one 2010;5(1):e8558.
2010: Yunxia Fan; Gregory P Boivin; Erik S Knudsen; Daniel W Nebert; Ying Xia; Alvaro Puga
The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesis.
Cancer research 2010;70(1):212-20.
2009: C A Reed; C N Mayhew; A K McClendon; X Yang; A Witkiewicz; Erik S Knudsen
RB has a critical role in mediating the in vivo checkpoint response, mitigating secondary DNA damage and suppressing liver tumorigenesis initiated by aflatoxin B1.
Oncogene 2009;28(50):4434-43.
2009: Clay E S Comstock; Michael A Augello; Ruth Pe Benito; Jason Karch; Thai H Tran; Fransiscus E Utama; Elizabeth A Tindall; Ying Wang; Craig J Burd; Eric M Groh; Hoa N Hoang; Graham G Giles; Gianluca Severi; Vanessa M Hayes; Brian E Henderson; Loic Le Marchand; Laurence N Kolonel; Christopher A Haiman; Raffaele Baffa; Leonard G Gomella; Erik S Knudsen; Hallgeir Rui; Susan M Henshall; Robert L Sutherland; Karen E Knudsen
Cyclin D1 splice variants: polymorphism, risk, and isoform-specific regulation in prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(17):5338-49.
2009: Kristy R Stengel; Chellappagounder Thangavel; David A Solomon; Steven P. Angus; Yi Zheng; Erik S Knudsen
Retinoblastoma/p107/p130 pocket proteins: protein dynamics and interactions with target gene promoters.
The Journal of biological chemistry 2009;284(29):19265-71.
2009: Ryan J Bourgo; Hasan Siddiqui; Sejal Fox; David Solomon; Courtney G Sansam; moshe yaniv; Christian Muchardt; Daniel Metzger; Pierre Chambon; Charles W M Roberts; Erik S Knudsen
SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacity.
Molecular biology of the cell 2009;20(14):3192-9.
2009: Paola Rojas; Fernando Benavides; Jorge Blando; Carlos Perez; Kim Cardenas; Ellen R Richie; Erik S Knudsen; David G Johnson; Adrian M Senderowicz; Marcelo L Rodriguez-Puebla; Claudio J Conti
Enhanced skin carcinogenesis and lack of thymus hyperplasia in transgenic mice expressing human cyclin D1b (CCND1b).
Molecular carcinogenesis 2009;48(6):508-16.
2009: E K A Millar; J L Dean; C M McNeil; Sandra Alison O'Toole; Susan M Henshall; T Tran; J Lin; A Quong; C E S Comstock; A Witkiewicz; Elizabeth A Musgrove; H Rui; L Lemarchand; V W Setiawan; C A Haiman; K E Knudsen; Robert L Sutherland; Erik S Knudsen
Cyclin D1b protein expression in breast cancer is independent of cyclin D1a and associated with poor disease outcome.
Oncogene 2009;28(15):1812-20.
2009: Federica Sotgia; francesco del galdo; Mathew C Casimiro; Gloria Bonuccelli; Isabelle Mercier; Diana Whitaker-Menezes; Kristin M Daumer; Jie Zhou; Chenguang Wang; Sanjay Katiyar; Huan Xu; Emily Bosco; Andrew A Quong; Bruce Aronow; Agnieszka Witkiewicz; Carlo Minetti; Philippe G Frank; Sergio A Jimenez; Erik S Knudsen; Richard G Pestell; Michael P Lisanti
Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts.
The American journal of pathology 2009;174(3):746-61.
2009: Federica Sotgia; Mathew C Casimiro; Gloria Bonuccelli; Manran Liu; Diana Whitaker-Menezes; Ozlem Er; Kristin M Daumer; Isabelle Mercier; Agnieszka K Witkiewicz; Carlo Minetti; Franco Capozza; Michael Gormley; Andrew A Quong; Hallgeir Rui; Philippe G Frank; Janet N Milliman; Erik S Knudsen; Jie Zhou; Chenguang Wang; Richard G Pestell; Michael P Lisanti
Loss of caveolin-3 induces a lactogenic microenvironment that is protective against mammary tumor formation.
The American journal of pathology 2009;174(2):613-29.
2009: Ryan J Bourgo; Wesley A Braden; Susanne I Wells; Erik S Knudsen
Activation of the retinoblastoma tumor suppressor mediates cell cycle inhibition and cell death in specific cervical cancer cell lines.
Molecular carcinogenesis 2009;48(1):45-55.
2008: W A Braden; A K McClendon; Erik S Knudsen
Cyclin-dependent kinase 4/6 activity is a critical determinant of pre-replication complex assembly.
Oncogene 2008;27(56):7083-93.
2008: Melissa Popowski; Heather A Ferguson; Amy M Sion; Erich Koller; Erik S Knudsen; Carla L Van Den Berg
Stress and IGF-I differentially control cell fate through mammalian target of rapamycin (mTOR) and retinoblastoma protein (pRB).
The Journal of biological chemistry 2008;283(42):28265-73.
2008: Erik S Knudsen; Karen E Knudsen
Tailoring to RB: tumour suppressor status and therapeutic response.
Nature reviews. Cancer 2008;8(9):714-24.
2008: E E Hoskins; R W Gunawardena; K B Habash; Trisha M Wise-Draper; Michael Jansen; Erik S Knudsen; S I Wells
Coordinate regulation of Fanconi anemia gene expression occurs through the Rb/E2F pathway.
Oncogene 2008;27(35):4798-808.
2008: Jennifer L Marlowe; Yunxia Fan; Xiaoqing Chang; Li Peng; Erik S Knudsen; Ying Xia; Alvaro Puga
The aryl hydrocarbon receptor binds to E2F1 and inhibits E2F1-induced apoptosis.
Molecular biology of the cell 2008;19(8):3263-71.
2008: Isabelle Mercier; Mathew C Casimiro; Chenguang Wang; Anne L Rosenberg; Judy Quong; Alimatou Minkeu; Kathleen G Allen; Christiane Danilo; Federica Sotgia; Gloria Bonuccelli; Jean-François Jasmin; Huan Xu; Emily Bosco; Bruce Aronow; Agnieszka Witkiewicz; Richard G Pestell; Erik S Knudsen; Michael P Lisanti
Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 downregulation and RB tumor suppressor functional inactivation: Implications for the response to hormonal therapy.
Cancer biology & therapy 2008;7(8):1212-25.
2008: Ying Wang; Jeffry L Dean; Ewan K A Millar; Thai Hong Tran; Catriona M McNeil; Craig J Burd; Susan M Henshall; Fransiscus E Utama; Agnieszka Witkiewicz; Hallgeir Rui; Robert L Sutherland; Karen E Knudsen; Erik S Knudsen
Cyclin D1b is aberrantly regulated in response to therapeutic challenge and promotes resistance to estrogen antagonists.
Cancer research 2008;68(14):5628-38.
2008: Li Peng; Christopher N Mayhew; Michael Schnekenburger; Erik S Knudsen; Alvaro Puga
Repression of Ah receptor and induction of transforming growth factor-beta genes in DEN-induced mouse liver tumors.
Toxicology 2008;246(2-3):242-7.
2008: Kristy R Stengel; Jeffry L Dean; Sarah L Seeley; Christopher N Mayhew; Erik S Knudsen
RB status governs differential sensitivity to cytotoxic and molecularly-targeted therapeutic agents.
Cell cycle (Georgetown, Tex.) 2008;7(8):1095-103.
2008: Deidre Daria; Marie-Dominique Filippi; Erik S Knudsen; Roberta Faccio; Zhixiong Li; Theodosia A Kalfa; Hartmut Geiger
The retinoblastoma tumor suppressor is a critical intrinsic regulator for hematopoietic stem and progenitor cells under stress.
Blood 2008;111(4):1894-902.
2007: Michael F Reed; William A Zagorski; Erik S Knudsen
RB activity alters checkpoint response and chemosensitivity in lung cancer lines.
The Journal of surgical research 2007;142(2):364-72.
2007: Michael P Markey; J Bergseid; Emily E Bosco; K Stengel; H Xu; Christopher N Mayhew; Sandy Schwemberger; Wesley A Braden; Y Jiang; George Babcock; anil jegga; Bruce Aronow; Michael F Reed; J Y J Wang; Erik S Knudsen
Loss of the retinoblastoma tumor suppressor: differential action on transcriptional programs related to cell cycle control and immune function.
Oncogene 2007;26(43):6307-18.
2007: Christopher N Mayhew; Scott L Carter; Sejal R Fox; Charlene R Sexton; Christopher A Reed; Seetha V Srinivasan; Xiangdong Liu; Kathryn Ann Wikenheiser-Brokamp; Gregory P Boivin; Ju Seog Lee; Bruce Aronow; Snorri S Thorgeirsson; Erik S Knudsen
RB loss abrogates cell cycle control and genome integrity to promote liver tumorigenesis.
Gastroenterology 2007;133(3):976-84.
2007: William A Zagorski; Erik S Knudsen; Michael F Reed
Retinoblastoma deficiency increases chemosensitivity in lung cancer.
Cancer research 2007;67(17):8264-73.
2007: Seetha V Srinivasan; Christopher N Mayhew; Sandy Schwemberger; William A Zagorski; Erik S Knudsen
RB loss promotes aberrant ploidy by deregulating levels and activity of DNA replication factors.
The Journal of biological chemistry 2007;282(33):23867-77.
2007: Ranjaka W Gunawardena; Sejal R Fox; Hasan Siddiqui; Erik S Knudsen
SWI/SNF activity is required for the repression of deoxyribonucleotide triphosphate metabolic enzymes via the recruitment of mSin3B.
The Journal of biological chemistry 2007;282(28):20116-23.
2007: Ankur Sharma; Clay E S Comstock; Erik S Knudsen; Khanh H Cao; Janet K Hess-Wilson; Lisa M Morey; Jason Barrera; Karen E Knudsen
Retinoblastoma tumor suppressor status is a critical determinant of therapeutic response in prostate cancer cells.
Cancer research 2007;67(13):6192-203.
2007: Hasan Siddiqui; Sejal R Fox; Ranjaka W Gunawardena; Erik S Knudsen
Loss of RB compromises specific heterochromatin modifications and modulates HP1alpha dynamics.
Journal of cellular physiology 2007;211(1):131-7.
2007: Emily E Bosco; Erik S Knudsen
RB in breast cancer: at the crossroads of tumorigenesis and treatment.
Cell cycle (Georgetown, Tex.) 2007;6(6):667-71.
2007: Sarah L Seeley; Emily E Bosco; Elizabeth Kramer; Linda M Parysek; Erik S Knudsen
Distinct roles for RB loss on cell cycle control, cisplatin response, and immortalization in Schwann cells.
Cancer letters 2007;245(1-2):205-17.
2007: Emily E Bosco; Ying Wang; Huan Xu; Jack T Zilfou; Karen E Knudsen; Bruce Aronow; Scott W Lowe; Erik S Knudsen
The retinoblastoma tumor suppressor modifies the therapeutic response of breast cancer.
The Journal of clinical investigation 2007;117(1):218-28.
2006: Erik S Knudsen; Charlene R Sexton; Christopher N Mayhew
Role of the retinoblastoma tumor suppressor in the maintenance of genome integrity.
Current molecular medicine 2006;6(7):749-57.
2006: Wesley A Braden; Jon M Lenihan; Zhengdao Lan; K Scott Luce; William A Zagorski; Emily E Bosco; Michael F Reed; Jeanette Gowen Cook; Erik S Knudsen
Distinct action of the retinoblastoma pathway on the DNA replication machinery defines specific roles for cyclin-dependent kinase complexes in prereplication complex assembly and S-phase progression.
Molecular and cellular biology 2006;26(20):7667-81.
2006: Erik S Knudsen; Karen E Knudsen
Retinoblastoma tumor suppressor: where cancer meets the cell cycle.
Experimental biology and medicine (Maywood, N.J.) 2006;231(7):1271-81.
2006: Michael F Reed; William A Zagorski; John A Howington; Jack T Zilfou; Erik S Knudsen
Inhibition of retinoblastoma tumor suppressor activity by RNA interference in lung cancer lines.
The Annals of thoracic surgery 2006;82(1):249-53.
2006: Karen E Knudsen; J Alan Diehl; Christopher A Haiman; Erik S Knudsen
Cyclin D1: polymorphism, aberrant splicing and cancer risk.
Oncogene 2006;25(11):1620-8.
2006: Jeffrey A Knauf; Bin Ouyang; Erik S Knudsen; Kenji Fukasawa; George Babcock; James A Fagin
Oncogenic RAS induces accelerated transition through G2/M and promotes defects in the G2 DNA damage and mitotic spindle checkpoints.
The Journal of biological chemistry 2006;281(7):3800-9.
2006: Craig J Burd; Christin E Petre; Lisa M Morey; Ying Wang; Monica P Revelo; Christopher A Haiman; Shan Lu; Cecilia Fenoglio-Preiser; Jiwen Li; Erik S Knudsen; Jiemin Wong; Karen E Knudsen
Cyclin D1b variant influences prostate cancer growth through aberrant androgen receptor regulation.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(7):2190-5.
2005: Christopher N Mayhew; Emily E Bosco; Sejal R Fox; Tomohisa Okaya; Pheruza Tarapore; Sandy Schwemberger; George Babcock; Alex B Lentsch; Kenji Fukasawa; Erik S Knudsen
Liver-specific pRB loss results in ectopic cell cycle entry and aberrant ploidy.
Cancer research 2005;65(11):4568-77.
2005: fatima banine; Christopher Bartlett; Ranjaka W Gunawardena; Christian Muchardt; Moshe Yaniv; Erik S Knudsen; Bernard E Weissman; Larry S Sherman
SWI/SNF chromatin-remodeling factors induce changes in DNA methylation to promote transcriptional activation.
Cancer research 2005;65(9):3542-7.
2005: Feng-Qi An; Nicole Compitello; Edward Horwitz; Michael Sramkoski; Erik S Knudsen; Rolf Renne
The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus modulates cellular gene expression and protects lymphoid cells from p16 INK4A-induced cell cycle arrest.
The Journal of biological chemistry 2005;280(5):3862-74.
2005: Emily E Bosco; Erik S Knudsen
Differential role of RB in response to UV and IR damage.
Nucleic acids research 2005;33(5):1581-92.
2004: David A Solomon; M Cristina Cardoso; Erik S Knudsen
Dynamic targeting of the replication machinery to sites of DNA damage.
The Journal of cell biology 2004;166(4):455-63.
2004: Jennifer L Marlowe; Erik S Knudsen; Sandy Schwemberger; Alvaro Puga
The aryl hydrocarbon receptor displaces p300 from E2F-dependent promoters and represses S phase-specific gene expression.
The Journal of biological chemistry 2004;279(28):29013-22.
2004: Ranjaka W Gunawardena; Hasan Siddiqui; David A Solomon; Christopher N Mayhew; Justin Held; Steven P. Angus; Erik S Knudsen
Hierarchical requirement of SWI/SNF in retinoblastoma tumor suppressor-mediated repression of Plk1.
The Journal of biological chemistry 2004;279(28):29278-85.
2004: Michael P Markey; Hasan Siddiqui; Erik S Knudsen
Geminin is targeted for repression by the retinoblastoma tumor suppressor pathway through intragenic E2F sites.
The Journal of biological chemistry 2004;279(28):29255-62.
2004: Steven P. Angus; Christopher N Mayhew; David A Solomon; Wesley A Braden; Michael P Markey; Yukiko Okuno; M Cristina Cardoso; David M Gilbert; Erik S Knudsen
RB reversibly inhibits DNA replication via two temporally distinct mechanisms.
Molecular and cellular biology 2004;24(12):5404-20.
2004: Christopher N Mayhew; Lisa M Perkin; Xiaoping Zhang; Julien Sage; Tyler Jacks; Erik S Knudsen
Discrete signaling pathways participate in RB-dependent responses to chemotherapeutic agents.
Oncogene 2004;23(23):4107-20.
2004: John T Powers; SungKi Hong; Christopher N Mayhew; Pamela M Rogers; Erik S Knudsen; David G Johnson
E2F1 uses the ATM signaling pathway to induce p53 and Chk2 phosphorylation and apoptosis.
Molecular cancer research : MCR 2004;2(4):203-14.
2004: Christopher N Mayhew; Emily E Bosco; David A Solomon; Erik S Knudsen; Steven P. Angus
Analysis of RB action in DNA damage checkpoint response.
Methods in molecular biology (Clifton, N.J.) 2004;281():3-16.
2004: Emily E Bosco; Christopher N Mayhew; Robert F Hennigan; Julien Sage; Tyler Jacks; Erik S Knudsen
RB signaling prevents replication-dependent DNA double-strand breaks following genotoxic insult.
Nucleic acids research 2004;32(1):25-34.
2003: Steven P. Angus; David A Solomon; Lioba Kuschel; Robert F Hennigan; Erik S Knudsen
Retinoblastoma tumor suppressor: analyses of dynamic behavior in living cells reveal multiple modes of regulation.
Molecular and cellular biology 2003;23(22):8172-88.
2003: Hasan Siddiqui; David A Solomon; Ranjaka W Gunawardena; Ying Wang; Erik S Knudsen
Histone deacetylation of RB-responsive promoters: requisite for specific gene repression but dispensable for cell cycle inhibition.
Molecular and cellular biology 2003;23(21):7719-31.
2003: Niharika Nath; Sheng Wang; Vicki Betts; Erik S Knudsen; Srikumar Chellappan
Apoptotic and mitogenic stimuli inactivate Rb by differential utilization of p38 and cyclin-dependent kinases.
Oncogene 2003;22(38):5986-94.
2003: Sunita Gupta; Mai X Luong; Sylvia A Bleuming; Angela Miele; Michael Luong; Daniel Young; Erik S Knudsen; Andre J van Wijnen; Janet L Stein; Gary S Stein
Tumor suppressor pRB functions as a co-repressor of the CCAAT displacement protein (CDP/cut) to regulate cell cycle controlled histone H4 transcription.
Journal of cellular physiology 2003;196(3):541-56.
2003: David A Solomon; Ying Wang; Sejal R Fox; Tah C Lambeck; Sarah Giesting; Zhengdao Lan; Adrian M Senderowicz; Claudio J Conti; Erik S Knudsen
Cyclin D1 splice variants. Differential effects on localization, RB phosphorylation, and cellular transformation.
The Journal of biological chemistry 2003;278(32):30339-47.
2003: Erik S Knudsen; Steven P. Angus
Functional analysis of the antimitogenic activity of tumor suppressors.
Methods in molecular biology (Clifton, N.J.) 2003;218():3-15.
2002: Alvaro Puga; Jennifer L Marlowe; Sonya Barnes; Ching-yi Chang; Andrew Maier; Zongqing Tan; J Kevin Kerzee; Xaoqing Chang; Matthew W Strobeck; Erik S Knudsen
Role of the aryl hydrocarbon receptor in cell cycle regulation.
Toxicology 2002;181-182():171-7.
2002: Michael P Markey; Steven P. Angus; Matthew W Strobeck; Sarah L Williams; Ranjaka W Gunawardena; Bruce Aronow; Erik S Knudsen
Unbiased analysis of RB-mediated transcriptional repression identifies novel targets and distinctions from E2F action.
Cancer research 2002;62(22):6587-97.
2002: Steven P. Angus; Linda J Wheeler; Sejal A Ranmal; Xiaoping Zhang; Michael P Markey; Christopher K Mathews; Erik S Knudsen
Retinoblastoma tumor suppressor targets dNTP metabolism to regulate DNA replication.
The Journal of biological chemistry 2002;277(46):44376-84.
2002: Christopher D. Heinen; Kathleen Heppner Goss; James R Cornelius; George Babcock; Erik S Knudsen; Timothy F Kowalik; Joanna Groden
The APC tumor suppressor controls entry into S-phase through its ability to regulate the cyclin D/RB pathway.
Gastroenterology 2002;123(3):751-63.
2002: Bryan Lorris Betz; Matthew W Strobeck; David N Reisman; Erik S Knudsen; Bernard E Weissman
Re-expression of hSNF5/INI1/BAF47 in pediatric tumor cells leads to G1 arrest associated with induction of p16ink4a and activation of RB.
Oncogene 2002;21(34):5193-203.
2002: Steven P. Angus; Anne F Fribourg; Michael P Markey; Sarah L Williams; Henning F Horn; James DeGregori; Timothy F Kowalik; Kenji Fukasawa; Erik S Knudsen
Active RB elicits late G1/S inhibition.
Experimental cell research 2002;276(2):201-13.
2002: Zhengdao Lan; Zvjezdana Sever-Chroneos; Matthew W Strobeck; Chi-Hyun Park; R Baskaran; Winfried Edelmann; Gustavo Leone; Erik S Knudsen
DNA damage invokes mismatch repair-dependent cyclin D1 attenuation and retinoblastoma signaling pathways to inhibit CDK2.
The Journal of biological chemistry 2002;277(10):8372-81.
2002: Matthew W Strobeck; David N Reisman; Ranjaka W Gunawardena; Bryan Lorris Betz; Steven P. Angus; Karen E Knudsen; Timothy F Kowalik; Bernard E Weissman; Erik S Knudsen
Compensation of BRG-1 function by Brm: insight into the role of the core SWI-SNF subunits in retinoblastoma tumor suppressor signaling.
The Journal of biological chemistry 2002;277(7):4782-9.
2002: David N Reisman; Matthew W Strobeck; Bryan Lorris Betz; Janiece Sciariotta; William K Funkhouser; Christian Murchardt; Moshe Yaniv; Larry S Sherman; Erik S Knudsen; Bernard E Weissman
Concomitant down-regulation of BRM and BRG1 in human tumor cell lines: differential effects on RB-mediated growth arrest vs CD44 expression.
Oncogene 2002;21(8):1196-207.
2002: Jaclyn A Biegel; Ganjam V Kalpana; Erik S Knudsen; Roger J Packer; Charles M Roberts; Carol Jeanne Thiele; Bernard E Weissman; Malcolm Smith
The role of INI1 and the SWI/SNF complex in the development of rhabdoid tumors: meeting summary from the workshop on childhood atypical teratoid/rhabdoid tumors.
Cancer research 2002;62(1):323-8.
2001: Zvjezdana Sever-Chroneos; Steven P. Angus; Anne F Fribourg; H Wan; I Todorov; Karen E Knudsen; Erik S Knudsen
Retinoblastoma tumor suppressor protein signals through inhibition of cyclin-dependent kinase 2 activity to disrupt PCNA function in S phase.
Molecular and cellular biology 2001;21(12):4032-45.
2001: Matthew W Strobeck; MF DeCristofaro; fatima banine; Bernard E Weissman; Larry S Sherman; Erik S Knudsen
The BRG-1 subunit of the SWI/SNF complex regulates CD44 expression.
The Journal of biological chemistry 2001;276(12):9273-8.
2000: Karen E Knudsen; D Booth; Soheil Naderi; Zvjezdana Sever-Chroneos; Anne F Fribourg; Irina C Hunton; James R Feramisco; Jean Y J Wang; Erik S Knudsen
RB-dependent S-phase response to DNA damage.
Molecular and cellular biology 2000;20(20):7751-63.
2000: Masaru Okuda; Henning F Horn; Pheruza Tarapore; Yukari Tokuyama; A George Smulian; P K Chan; Erik S Knudsen; I A Hofmann; J D Snyder; Kevin E Bove; Kenji Fukasawa
Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication.
Cell 2000;103(1):127-40.
2000: Matthew W Strobeck; Karen E Knudsen; Anne F Fribourg; MF DeCristofaro; Bernard E Weissman; A N Imbalzano; Erik S Knudsen
BRG-1 is required for RB-mediated cell cycle arrest.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(14):7748-53.
2000: Anne F Fribourg; Karen E Knudsen; Matthew W Strobeck; C M Lindhorst; Erik S Knudsen
Differential requirements for ras and the retinoblastoma tumor suppressor protein in the androgen dependence of prostatic adenocarcinoma cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2000;11(7):361-72.
2000: Matthew W Strobeck; Anne F Fribourg; Alvaro Puga; Erik S Knudsen
Restoration of retinoblastoma mediated signaling to Cdk2 results in cell cycle arrest.
Oncogene 2000;19(15):1857-67.
2000: Alvaro Puga; S J Barnes; Timothy P Dalton; C y Chang; Erik S Knudsen; M A Maier
Aromatic hydrocarbon receptor interaction with the retinoblastoma protein potentiates repression of E2F-dependent transcription and cell cycle arrest.
The Journal of biological chemistry 2000;275(4):2943-50.
1999: Karen E Knudsen; Anne F Fribourg; Matthew W Strobeck; J M Blanchard; Erik S Knudsen
Cyclin A is a functional target of retinoblastoma tumor suppressor protein-mediated cell cycle arrest.
The Journal of biological chemistry 1999;274(39):27632-41.
1999: Karen E Knudsen; E Weber; Karen C Arden; Webster K Cavenee; James R Feramisco; Erik S Knudsen
The retinoblastoma tumor suppressor inhibits cellular proliferation through two distinct mechanisms: inhibition of cell cycle progression and induction of cell death.
Oncogene 1999;18(37):5239-45.
1999: E Weber; Rajani Ravi; Erik S Knudsen; JR Williams; Larry E Dillehay; Barry D Nelkin; Gregory P Kalemkerian; James R Feramisco; M Mabry
Retinoic acid-mediated growth inhibition of small cell lung cancer cells is associated with reduced myc and increased p27Kip1 expression.
International journal of cancer. Journal international du cancer 1999;80(6):935-43.
1998: Erik S Knudsen; C Buckmaster; Tung-Ti Chen; James R Feramisco; Jean Y J Wang
Inhibition of DNA synthesis by RB: effects on G1/S transition and S-phase progression.
Genes & development 1998;12(15):2278-92.
1998: LL Whitaker; H Su; R Baskaran; Erik S Knudsen; Jean Y J Wang
Growth suppression by an E2F-binding-defective retinoblastoma protein (RB): contribution from the RB C pocket.
Molecular and cellular biology 1998;18(7):4032-42.
1998: Erik S Knudsen; C Pazzagli; T L Born; B L Bertolaet; Karen E Knudsen; Karen C Arden; R R Henry; James R Feramisco
Elevated cyclins and cyclin-dependent kinase activity in the rhabdomyosarcoma cell line RD.
Cancer research 1998;58(9):2042-9.
1998: Erik S Knudsen; Jean Y J Wang
Hyperphosphorylated p107 and p130 bind to T-antigen: identification of a critical regulatory sequence present in RB but not in p107/p130.
Oncogene 1998;16(13):1655-63.
1997: W Arap; Erik S Knudsen; Duane A Sewell; David Sidransky; Jean Y J Wang; H J Huang; Webster K Cavenee
Functional analysis of wild-type and malignant glioma derived CDKN2Abeta alleles: evidence for an RB-independent growth suppressive pathway.
Oncogene 1997;15(17):2013-20.
1997: Erik S Knudsen; Jean Y J Wang
Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation.
Molecular and cellular biology 1997;17(10):5771-83.
1997: Mandri Obeyesekere; Erik S Knudsen; Jean Y J Wang; Stuart O Zimmerman
A mathematical model of the regulation of the G1 phase of Rb+/+ and Rb-/- mouse embryonic fibroblasts and an osteosarcoma cell line.
Cell proliferation 1997;30(3-4):171-94.
1997: W Arap; Erik S Knudsen; Jean Y J Wang; Webster K Cavenee; H J Huang
Point mutations can inactivate in vitro and in vivo activities of p16(INK4a)/CDKN2A in human glioma.
Oncogene 1997;14(5):603-9.
1996: Yan Chen; Erik S Knudsen; Jean Y J Wang
The RB/p107/p130 phosphorylation pathway is not inhibited in rapamycin-induced G1-prolongation of NIH3T3 cells.
Oncogene 1996;13(8):1765-71.
1996: Yan Chen; Erik S Knudsen; Jean Y J Wang
Cells arrested in G1 by the v-Abl tyrosine kinase do not express cyclin A despite the hyperphosphorylation of RB.
The Journal of biological chemistry 1996;271(33):19637-40.
1996: Karen E Knudsen; Erik S Knudsen; Jean Y J Wang; Suresh Subramani
p34cdc2 kinase activity is maintained upon activation of the replication checkpoint in Schizosaccharomyces pombe.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8278-83.
1996: Erik S Knudsen; Jean Y J Wang
Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sites.
The Journal of biological chemistry 1996;271(14):8313-20.
1994: Jean Y J Wang; Erik S Knudsen; P J Welch
The retinoblastoma tumor suppressor protein.
Advances in cancer research 1994;64():25-85.