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Joyce Knutson

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René St-Arnaud; Alice Arabian; V W C Yu; Omar Akhouayri; Joyce C Knutson; S A Strugnell
1α,24(S)(OH)2D2 normalizes bone morphology and serum parathyroid hormone without hypercalcemia in 25-hydroxyvitamin D-1-hydroxylase (CYP27B1)-deficient mice, an animal model of vitamin D deficiency with secondary hyperparathyroidism.
Glenville Jones; Valarie Byford; Shelly West; Sonoko Masuda; George Ibrahim; Martin Kaufmann; Joyce C Knutson; Stephen A Strugnell; Rajendra Mehta
Hepatic activation and inactivation of clinically-relevant vitamin D analogs and prodrugs.
Alex J Brown; Cynthia S Ritter; Joyce C Knutson; Stephen A Strugnell
The vitamin D prodrugs 1alpha(OH)D2, 1alpha(OH)D3 and BCI-210 suppress PTH secretion by bovine parathyroid cells.

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All Publications

2008: René St-Arnaud; Alice Arabian; V W C Yu; Omar Akhouayri; Joyce C Knutson; S A Strugnell
1α,24(S)(OH)2D2 normalizes bone morphology and serum parathyroid hormone without hypercalcemia in 25-hydroxyvitamin D-1-hydroxylase (CYP27B1)-deficient mice, an animal model of vitamin D deficiency with secondary hyperparathyroidism.
Journal of endocrinological investigation 2008;31(8):711-7.
2006: Glenville Jones; Valarie Byford; Shelly West; Sonoko Masuda; George Ibrahim; Martin Kaufmann; Joyce C Knutson; Stephen A Strugnell; Rajendra Mehta
Hepatic activation and inactivation of clinically-relevant vitamin D analogs and prodrugs.
Anticancer research 2006;26(4A):2589-95.
2006: Alex J Brown; Cynthia S Ritter; Joyce C Knutson; Stephen A Strugnell
The vitamin D prodrugs 1alpha(OH)D2, 1alpha(OH)D3 and BCI-210 suppress PTH secretion by bovine parathyroid cells.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2006;21(3):644-50.
2006: Sonoko Masuda; Stephen A Strugnell; Joyce C Knutson; René St-Arnaud; Glenville Jones
Evidence for the activation of 1alpha-hydroxyvitamin D2 by 25-hydroxyvitamin D-24-hydroxylase: delineation of pathways involving 1alpha,24-dihydroxyvitamin D2 and 1alpha,25-dihydroxyvitamin D2.
Biochimica et biophysica acta 2006;1761(2):221-34.
2005: Y R Wang; Don Wigington; Stephen A Strugnell; Joyce C Knutson
Growth inhibition of cancer cells by an active metabolite of a novel vitamin D prodrug.
Anticancer research 2005;25(6B):4333-9.
2005: Don Wigington; Stephen A Strugnell; Joyce C Knutson
Pamidronate and 1,24(S)-dihydroxyvitamin D2 synergistically inhibit the growth of myeloma, breast and prostate cancer cells.
Anticancer research 2005;25(3B):1909-17.
2005: Glendon M Zinser; Emily Tribble; Meggan Valrance; Colleen M Urben; Joyce C Knutson; Richard B Mazess; Stephen A Strugnell; JoEllen Welsh
1,24(S)-dihydroxyvitamin D2, an endogenous vitamin D2 metabolite, inhibits growth of breast cancer cells and tumors.
Anticancer research 2005;25(1A):235-41.
2004: Alex J Brown; Cynthia S Ritter; L Shannon Holliday; Joyce C Knutson; Stephen A Strugnell
Tissue distribution and activity studies of 1,24-dihydroxyvitamin D2, a metabolite of vitamin D2 with low calcemic activity in vivo.
Biochemical pharmacology 2004;68(7):1289-96.
2004: Don Wigington; Colleen M Urben; Stephen A Strugnell; Joyce C Knutson
Combination study of 1,24(S)-dihydroxyvitamin D2 and chemotherapeutic agents on human breast and prostate cancer cell lines.
Anticancer research 2004;24(5A):2905-12.
2004: Sonoko Masuda; Martin Kaufmann; Valarie Byford; Mian Gao; René St-Arnaud; Alice Arabian; Hugh L J Makin; Joyce C Knutson; Stephen A Strugnell; Glenville Jones
Insights into Vitamin D metabolism using cyp24 over-expression and knockout systems in conjunction with liquid chromatography/mass spectrometry (LC/MS).
The Journal of steroid biochemistry and molecular biology 2004;89-90(1-5):149-53.
2003: Robert A Upton; Joyce C Knutson; Charles W Bishop; Leon W LeVan
Pharmacokinetics of doxercalciferol, a new vitamin D analogue that lowers parathyroid hormone.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2003;18(4):750-8.
2002: Valarie Byford; Stephen A Strugnell; Ruth Coldwell; Neil J Schroeder; Hugh L J Makin; Joyce C Knutson; Charles W Bishop; Glenville Jones
Use of vitamin D(4) analogs to investigate differences in hepatic and target cell metabolism of vitamins D(2) and D(3).
Biochimica et biophysica acta 2002;1583(2):151-66.
1998: EB Mawer; Glenville Jones; Michael Davies; P E Still; Valarie Byford; Neil J Schroeder; Hugh L J Makin; Charles W Bishop; Joyce C Knutson
Unique 24-hydroxylated metabolites represent a significant pathway of metabolism of vitamin D2 in humans: 24-hydroxyvitamin D2 and 1,24-dihydroxyvitamin D2 detectable in human serum.
The Journal of clinical endocrinology and metabolism 1998;83(6):2156-66.
1997: Joyce C Knutson; L W LeVan; C R Valliere; Charles W Bishop
Pharmacokinetics and systemic effect on calcium homeostasis of 1 alpha,24-dihydroxyvitamin D2 in rats. Comparison with 1 alpha,25-dihydroxyvitamin D2, calcitriol, and calcipotriol.
Biochemical pharmacology 1997;53(6):829-37.
1997: A U Tan; BS Levine; Richard B Mazess; DM Kyllo; Charles W Bishop; Joyce C Knutson; K S Kleinman; Jack W Coburn
Effective suppression of parathyroid hormone by 1 alpha-hydroxy-vitamin D2 in hemodialysis patients with moderate to severe secondary hyperparathyroidism.
Kidney international 1997;51(1):317-23.
1996: Glenville Jones; V Byford; Hugh L J Makin; R Kremer; R H Rice; L A deGraffenried; Joyce C Knutson; Charles W Bishop
Anti-proliferative activity and target cell catabolism of the vitamin D analog 1 alpha,24(S)-(OH)2D2 in normal and immortalized human epidermal cells.
Biochemical pharmacology 1996;52(1):133-40.
1996: Jack W Coburn; A U Tan; B S Levine; R B Mazess; D M Kyllo; Joyce C Knutson; Charles W Bishop
1 alpha-Hydroxy-vitamin D2: a new look at an 'old' compound.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1996;11 Suppl 3():153-7.
1995: Joyce C Knutson; Bruce W Hollis; L W LeVan; C Valliere; K G Gould; Charles W Bishop
Metabolism of 1 alpha-hydroxyvitamin D2 to activated dihydroxyvitamin D 2 metabolites decreases endogenous 1 alpha, 25-dihydroxyvitamin D 3 in rats and monkeys.
Endocrinology 1995;136(11):4749-53.
1995: S Strugnell; V Byford; Hugh L J Makin; Robert M Moriarty; R Gilardi; L W LeVan; Joyce C Knutson; Charles W Bishop; Glenville Jones
1 alpha,24(S)-dihydroxyvitamin D2: a biologically active product of 1 alpha-hydroxyvitamin D2 made in the human hepatoma, Hep3B.
The Biochemical journal 1995;310 ( Pt 1)():233-41.
1994: J Christopher Gallagher; Charles W Bishop; Joyce C Knutson; R B Mazess; H F DeLuca
Effects of increasing doses of 1 alpha-hydroxyvitamin D2 on calcium homeostasis in postmenopausal osteopenic women.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1994;9(5):607-14.