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Christopher Bakkenist

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Shikhar Uttam; Kevin Staton; Sergey Alexandrov; Christopher J Bakkenist; Rajan K Bista; Randall E Brand; Serah Choi; Douglas J Hartman; Yang Liu
Investigation of depth-resolved nanoscale structural changes in regulated cell proliferation and chromatin decondensation.
Manoj Gandhi; Christopher J Bakkenist; Karen T Cuenco; Viktoria N Evdokimova; Yuri E Nikiforov
Homologous chromosomes move and rapidly initiate contact at the sites of double-strand breaks in genes in G₀-phase human cells.
Wei Qian; Christopher J Bakkenist; Serah Choi; Gregory A Gibson; Simon C Watkins; Bennett Van Houten
Mitochondrial hyperfusion induced by loss of the fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stress.

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All Publications

2013: Shikhar Uttam; Kevin Staton; Sergey Alexandrov; Christopher J Bakkenist; Rajan K Bista; Randall E Brand; Serah Choi; Douglas J Hartman; Yang Liu
Investigation of depth-resolved nanoscale structural changes in regulated cell proliferation and chromatin decondensation.
Biomedical optics express 2013;4(4):596-613.
2013: Manoj Gandhi; Christopher J Bakkenist; Karen T Cuenco; Viktoria N Evdokimova; Yuri E Nikiforov
Homologous chromosomes move and rapidly initiate contact at the sites of double-strand breaks in genes in G₀-phase human cells.
Cell cycle (Georgetown, Tex.) 2013;12(4):547-52.
2012: Wei Qian; Christopher J Bakkenist; Serah Choi; Gregory A Gibson; Simon C Watkins; Bennett Van Houten
Mitochondrial hyperfusion induced by loss of the fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stress.
Journal of cell science 2012;125(Pt 23):5745-57.
2012: Serah Choi; Thomas P Conrads; Banu Dost; Katherine Y Fu; Gregory A Gibson; Brian L Hood; Trey Ideker; Rohith Srivas; Bennett Van Houten; Simon C Watkins; Nuno Bandeira; Christopher J Bakkenist
Quantitative proteomics reveal ATM kinase-dependent exchange in DNA damage response complexes.
Journal of proteome research 2012;11(10):4983-91.
2012: Kenta Yamamoto; Christopher J Bakkenist; Richard L Dubois; Wenxia Jiang; Chyuan-Sheng Lin; Xiangyu Liu; Thomas Ludwig; Yunyue Wang; Shan Zha
Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice.
The Journal of cell biology 2012;198(3):305-13.
2012: Manoj Gandhi; Lindsey M Kelly; Christopher J Bakkenist; Viktoria N Evdokimova; Marina N Nikiforova; James R Stringer; Karen T Cuenco; Yuri E Nikiforov
Homologous chromosomes make contact at the sites of double-strand breaks in genes in somatic G0/G1-phase human cells.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(24):9454-9.
2012: Armin M Gamper; Yoshihiro Matsumoto; Alan E Tomkinson; Dibyendu Banerjee; Serah Choi; Christopher J Bakkenist
ATM protein physically and functionally interacts with proliferating cell nuclear antigen to regulate DNA synthesis.
The Journal of biological chemistry 2012;287(15):12445-54.
2011: Mark E Bernard; Michael W Epperly; Erin M Forbeck; Darcy Franicola; Marie-Celine Frantz; Julie P Goff; Frank Houghton; Hyun Kim; Donna Shields; Hong Wang; Peter Wipf; Xichen Zhang; Christopher J Bakkenist; Hebist Berhane; Joel S Greenberger
GS-nitroxide (JP4-039)-mediated radioprotection of human Fanconi anemia cell lines.
Radiation research 2011;176(5):603-12.
2011: Serah Choi; Oscar Fernandez-Capetillo; Luis I Toledo; Christopher J Bakkenist
CGK733 does not inhibit ATM or ATR kinase activity in H460 human lung cancer cells.
DNA repair 2011;10(10):1000-1; author reply 1002.
2011: Jason S White; Ning Yue; Jing Hu; Christopher J Bakkenist
The ATM kinase signaling induced by the low-energy β-particles emitted by (33)P is essential for the suppression of chromosome aberrations and is greater than that induced by the energetic β-particles emitted by (32)P.
Mutation research 2011;708(1-2):28-36.
2010: Serah Choi; Armin M Gamper; Jason S White; Christopher J Bakkenist
Inhibition of ATM kinase activity does not phenocopy ATM protein disruption: implications for the clinical utility of ATM kinase inhibitors.
Cell cycle (Georgetown, Tex.) 2010;9(20):4052-7.
2010: Malolan S Rajagopalan; Brandon Stone; Jean-Claude Rwigema; Umar Salimi; Michael W Epperly; Julie Goff; Darcy Franicola; Tracy Dixon; Shaonan Cao; Xichen Zhang; Bettina M Buchholz; Anthony J Bauer; Serah Choi; Christopher J Bakkenist; Hong Wang; Joel S Greenberger
Intraesophageal manganese superoxide dismutase-plasmid liposomes ameliorates novel total-body and thoracic radiation sensitivity of NOS1-/- mice.
Radiation research 2010;174(3):297-312.
2010: Xiang Xu; Jaya Vatsyayan; Chenxi Gao; Christopher J Bakkenist; Jing Hu
HDAC2 promotes eIF4E sumoylation and activates mRNA translation gene specifically.
The Journal of biological chemistry 2010;285(24):18139-43.
2010: Xiang Xu; Jaya Vatsyayan; Chenxi Gao; Christopher J Bakkenist; Jing Hu
Sumoylation of eIF4E activates mRNA translation.
EMBO reports 2010;11(4):299-304.
2010: Jason S White; Serah Choi; Christopher J Bakkenist
Transient ATM kinase inhibition disrupts DNA damage-induced sister chromatid exchange.
Science signaling 2010;3(124):ra44.
2009: Julie P Goff; Donna S Shields; Mineaki Seki; Serah Choi; Michael W Epperly; Tracy Dixon; Hong Wang; Christopher J Bakkenist; Stephen D Dertinger; Dorothea K Torous; John Wittschieben; Richard D Wood; Joel S Greenberger
Lack of DNA polymerase theta (POLQ) radiosensitizes bone marrow stromal cells in vitro and increases reticulocyte micronuclei after total-body irradiation.
Radiation research 2009;172(2):165-74.
2009: Olga Momcilović; Serah Choi; Sandra Varum; Christopher J Bakkenist; Gerald Schatten; Christopher S Navara
Ionizing radiation induces ataxia telangiectasia mutated-dependent checkpoint signaling and G(2) but not G(1) cell cycle arrest in pluripotent human embryonic stem cells.
Stem cells (Dayton, Ohio) 2009;27(8):1822-35.
2008: Jason S White; Serah Choi; Christopher J Bakkenist
Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity.
Cell cycle (Georgetown, Tex.) 2008;7(9):1277-84.
2007: Rahul A Parikh; Jason S White; Xin Huang; David W Schoppy; Bora E Baysal; Rajasekaran Baskaran; Christopher J Bakkenist; William S Saunders; Lih-Ching Hsu; Marjorie Romkes; Susanne M Gollin
Loss of distal 11q is associated with DNA repair deficiency and reduced sensitivity to ionizing radiation in head and neck squamous cell carcinoma.
Genes, chromosomes & cancer 2007;46(8):761-75.
2005: Jirina Bartkova; Christopher J Bakkenist; Ewa Rajpert-De Meyts; Niels E Skakkebaek; Maxwell Sehested; Jiri Lukas; Michael B Kastan; Jiri Bartek
ATM activation in normal human tissues and testicular cancer.
Cell cycle (Georgetown, Tex.) 2005;4(6):838-45.
2004: Jan Karlseder; Kristina Hoke; Olga K Mirzoeva; Christopher J Bakkenist; Michael B Kastan; John H J Petrini; Titia de Lange
The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response.
PLoS biology 2004;2(8):E240.
2004: Christopher J Bakkenist; Michael B Kastan
Initiating cellular stress responses.
Cell 2004;118(1):9-17.
2004: Christopher J Bakkenist; Michael B Kastan
Phosphatases join kinases in DNA-damage response pathways.
Trends in cell biology 2004;14(7):339-41.
2004: Risa Kitagawa; Christopher J Bakkenist; Peter J McKinnon; Michael B Kastan
Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway.
Genes & development 2004;18(12):1423-38.
2004: Christopher J Bakkenist; Rachid Drissi; Jing Wu; Michael B Kastan; Jeffrey S Dome
Disappearance of the telomere dysfunction-induced stress response in fully senescent cells.
Cancer research 2004;64(11):3748-52.
2004: Zuzana Horejsí; Jacob Falck; Christopher J Bakkenist; Michael B Kastan; Jiri Lukas; Jiri Bartek
Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation.
Oncogene 2004;23(17):3122-7.
2003: ML Cortés; Christopher J Bakkenist; M V Di Maria; Michael B Kastan; Xandra O Breakefield
HSV-1 amplicon vector-mediated expression of ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype.
Gene therapy 2003;10(16):1321-7.
2003: Christopher J Bakkenist; Michael B Kastan
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.
Nature 2003;421(6922):499-506.