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JW Ko

Research Profile

Chemicals & Drugs

Anatomy

Microsomes, Liver

Concepts & Ideas

Kinetics

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Publications

TOP 3
JW Ko; Zeruesenay Desta; Nadia Soukhova; T Tracy; David A Flockhart
In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6.
JW Ko; In-Jin Jang; Jae-Gook Shin; S K Nam; Sang-Goo Shin; David A Flockhart
Theophylline pharmacokinetics are not altered by lansoprazole in CYP2C19 poor metabolizers.
JW Ko; Zeruesenay Desta; David A Flockhart
Human N-demethylation of (S)-mephenytoin by cytochrome P450s 2C9 and 2B6.

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All Publications

2000: JW Ko; Zeruesenay Desta; Nadia Soukhova; T Tracy; David A Flockhart
In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6.
British journal of clinical pharmacology 2000;49(4):343-51.
1999: JW Ko; In-Jin Jang; Jae-Gook Shin; S K Nam; Sang-Goo Shin; David A Flockhart
Theophylline pharmacokinetics are not altered by lansoprazole in CYP2C19 poor metabolizers.
Clinical pharmacology and therapeutics 1999;65(6):606-14.
1998: JW Ko; Zeruesenay Desta; David A Flockhart
Human N-demethylation of (S)-mephenytoin by cytochrome P450s 2C9 and 2B6.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(8):775-8.
1998: Zeruesenay Desta; T Kerbusch; Nadia Soukhova; E Richard; JW Ko; David A Flockhart
Identification and characterization of human cytochrome P450 isoforms interacting with pimozide.
The Journal of pharmacology and experimental therapeutics 1998;285(2):428-37.
1997: S R Donahue; David A Flockhart; Darrell R. Abernethy; JW Ko
Ticlopidine inhibition of phenytoin metabolism mediated by potent inhibition of CYP2C19.
Clinical pharmacology and therapeutics 1997;62(5):572-7.
1997: JW Ko; N Sukhova; DL Thacker; P Chen; David A Flockhart
Evaluation of omeprazole and lansoprazole as inhibitors of cytochrome P450 isoforms.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(7):853-62.

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