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Soo Ko

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Carlton L Campbell; Carla Hassler; Soo S Ko; Matthew E Voss; Michael A Guaciaro; Percy H Carter; Robert J Cherney
Enantioselective synthesis of benzyl (1S,2R,4R)-4-(tert-butoxycarbonylamino)-2-(hydroxymethyl)cyclohexylcarbamate using an iodolactamization as the key step.
Daniel S Gardner; Joseph B Santella; Andrew J Tebben; Douglas G Batt; Soo S Ko; Sarah C Traeger; Patricia K Welch; Eric A Wadman; Paul Davies; Percy H Carter; John V Duncia
From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part II: Acyclic replacements for the (3S)-3-benzylpiperidine in a series of potent CCR3 antagonists.
Joseph B Santella; Daniel S Gardner; Wenqing Yao; Chongsheng Shi; Prabhakar Reddy; Andrew J Tebben; George V DeLucca; Dean A Wacker; Paul S Watson; Patricia K Welch; Eric A Wadman; Paul Davies; Kimberly A Solomon; Danielle Graden; Swamy Yeleswaram; Sandhya Mandlekar; Ilona Kariv; Carl P Decicco; Soo S Ko; Percy H Carter; John V Duncia
From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part I: the discovery of CCR3 antagonist development candidate BMS-639623 with picomolar inhibition potency against eosinophil chemotaxis.

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All Publications

2009: Carlton L Campbell; Carla Hassler; Soo S Ko; Matthew E Voss; Michael A Guaciaro; Percy H Carter; Robert J Cherney
Enantioselective synthesis of benzyl (1S,2R,4R)-4-(tert-butoxycarbonylamino)-2-(hydroxymethyl)cyclohexylcarbamate using an iodolactamization as the key step.
The Journal of organic chemistry 2009;74(16):6368-70.
2008: Daniel S Gardner; Joseph B Santella; Andrew J Tebben; Douglas G Batt; Soo S Ko; Sarah C Traeger; Patricia K Welch; Eric A Wadman; Paul Davies; Percy H Carter; John V Duncia
From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part II: Acyclic replacements for the (3S)-3-benzylpiperidine in a series of potent CCR3 antagonists.
Bioorganic & medicinal chemistry letters 2008;18(2):586-95.
2008: Joseph B Santella; Daniel S Gardner; Wenqing Yao; Chongsheng Shi; Prabhakar Reddy; Andrew J Tebben; George V DeLucca; Dean A Wacker; Paul S Watson; Patricia K Welch; Eric A Wadman; Paul Davies; Kimberly A Solomon; Danielle Graden; Swamy Yeleswaram; Sandhya Mandlekar; Ilona Kariv; Carl P Decicco; Soo S Ko; Percy H Carter; John V Duncia
From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part I: the discovery of CCR3 antagonist development candidate BMS-639623 with picomolar inhibition potency against eosinophil chemotaxis.
Bioorganic & medicinal chemistry letters 2008;18(2):576-85.
2007: James R Pruitt; Douglas G Batt; Dean A Wacker; Lori L Bostrom; Shon K Booker; Erin McLaughlin; Gregory C Houghton; Jeffrey G Varnes; David D Christ; Maryanne B Covington; Anuk M Das; Paul Davies; Danielle Graden; Ilona Kariv; Yevgeniya Orlovsky; Nicole C Stowell; Kris Vaddi; Eric A Wadman; Patricia K Welch; Swamy Yeleswaram; Kimberly A Solomon; Robert C Newton; Carl P Decicco; Percy H Carter; Soo S Ko
CC chemokine receptor-3 (CCR3) antagonists: improving the selectivity of DPC168 by reducing central ring lipophilicity.
Bioorganic & medicinal chemistry letters 2007;17(11):2992-7.
2006: Paul S Watson; Bin Jiang; Kim Harrison; Naoyuki Asakawa; Patricia K Welch; Maryanne B Covington; Nicole C Stowell; Eric A Wadman; Paul Davies; Kimberly A Solomon; Robert C Newton; George L Trainor; Steven M Friedman; Carl P Decicco; Soo S Ko
2,4-Disubstituted piperidines as selective CC chemokine receptor 3 (CCR3) antagonists: synthesis and selectivity.
Bioorganic & medicinal chemistry letters 2006;16(21):5695-9.
2006: Anuk M Das; Kris Vaddi; Kimberly A Solomon; Candice Krauthauser; Xiaosui Jiang; Kim McIntyre; Xiao Xia Yang; Eric A Wadman; Patricia K Welch; Maryanne B Covington; Danielle Graden; Krishnaswamy Yeleswaram; James M Trzaskos; Robert C Newton; Sandhya Mandlekar; Soo S Ko; Percy H Carter; Paul Davies
Selective inhibition of eosinophil influx into the lung by small molecule CC chemokine receptor 3 antagonists in mouse models of allergic inflammation.
The Journal of pharmacology and experimental therapeutics 2006;318(1):411-7.
2005: George V De Lucca; Ui Tae Kim; Brian J Vargo; John V Duncia; Joseph B Santella; Daniel S Gardner; Changsheng Zheng; Ann Y Liauw; Zhang Wang; George Emmett; Dean A Wacker; Patricia K Welch; Maryanne B Covington; Nicole C Stowell; Eric A Wadman; Anuk M Das; Paul Davies; Swamy Yeleswaram; Danielle Graden; Kimberly A Solomon; Robert C Newton; George L Trainor; Carl P Decicco; Soo S Ko
Discovery of CC chemokine receptor-3 (CCR3) antagonists with picomolar potency.
Journal of medicinal chemistry 2005;48(6):2194-211.
2004: Jeffrey G Varnes; Daniel S Gardner; Joseph B Santella; John V Duncia; Melissa Estrella; Paul S Watson; Cheryl M Clark; Soo S Ko; Patricia K Welch; Maryanne B Covington; Nicole C Stowell; Eric A Wadman; Paul Davies; Kimberley Solomon; Robert C Newton; George L Trainor; Carl P Decicco; Dean A Wacker
Discovery of N-propylurea 3-benzylpiperidines as selective CC chemokine receptor-3 (CCR3) antagonists.
Bioorganic & medicinal chemistry letters 2004;14(7):1645-9.
2002: George V De Lucca; Ui Tae Kim; Curt Johnson; Brian J Vargo; Patricia K Welch; Maryanne B Covington; Paul Davies; Kimberly A Solomon; Robert C Newton; George L Trainor; Carl P Decicco; Soo S Ko
Discovery and structure-activity relationship of N-(ureidoalkyl)-benzyl-piperidines as potent small molecule CC chemokine receptor-3 (CCR3) antagonists.
Journal of medicinal chemistry 2002;45(17):3794-804.
2002: Dean A Wacker; Joseph B Santella; Daniel S Gardner; Jeffrey G Varnes; Melissa Estrella; George V DeLucca; Soo S Ko; Keiichi Tanabe; Paul S Watson; Patricia K Welch; Maryanne B Covington; Nicole C Stowell; Eric A Wadman; Paul Davies; Kimberly A Solomon; Robert C Newton; George L Trainor; Steven M Friedman; Carl P Decicco; John V Duncia
CCR3 antagonists: a potential new therapy for the treatment of asthma. Discovery and structure-activity relationships.
Bioorganic & medicinal chemistry letters 2002;12(13):1785-9.
2001: AJ Cocuzza; DR Chidester; Beverly C Cordova; Ronald Klabe; S Jeffrey; Sharon Diamond; C A Weigelt; Soo S Ko; Lee Bacheler; Susan Erickson-Viitanen; James D Rodgers
4,1-Benzoxazepinone analogues of efavirenz (Sustiva) as HIV-1 reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry letters 2001;11(11):1389-92.
2001: AJ Cocuzza; DR Chidester; Beverly C Cordova; S Jeffrey; R L Parsons; Lee Bacheler; Susan Erickson-Viitanen; George L Trainor; Soo S Ko
Synthesis and evaluation of efavirenz (Sustiva) analogues as HIV-1 reverse transcriptase inhibitors: replacement of the cyclopropylacetylene side chain.
Bioorganic & medicinal chemistry letters 2001;11(9):1177-9.
2000: Jeffrey W Corbett; Soo S Ko; James D Rodgers; L A Gearhart; N A Magnus; Lee Bacheler; Sharon Diamond; S Jeffrey; Ronald Klabe; Beverly C Cordova; Sena Garber; Kelly Logue; George L Trainor; PS Anderson; Susan Erickson-Viitanen
Inhibition of clinically relevant mutant variants of HIV-1 by quinazolinone non-nucleoside reverse transcriptase inhibitors.
Journal of medicinal chemistry 2000;43(10):2019-30.
2000: Jeffrey W Corbett; L A Gearhart; Soo S Ko; James D Rodgers; Beverly C Cordova; Ronald Klabe; Susan Erickson-Viitanen
Novel 2,2-dioxide-4,4-disubstituted-1,3-H-2,1,3-benzothiadiazines as non-nucleoside reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry letters 2000;10(2):193-5.
1999: Jeffrey W Corbett; Soo S Ko; James D Rodgers; S Jeffrey; Lee Bacheler; Ronald Klabe; Sharon Diamond; C M Lai; S R Rabel; JA Saye; S P Adams; George L Trainor; PS Anderson; Susan Erickson-Viitanen
Expanded-spectrum nonnucleoside reverse transcriptase inhibitors inhibit clinically relevant mutant variants of human immunodeficiency virus type 1.
Antimicrobial agents and chemotherapy 1999;43(12):2893-7.
1999: Mona Patel; RJ McHugh; Beverly C Cordova; Ronald Klabe; Susan Erickson-Viitanen; George L Trainor; Soo S Ko
Synthesis and evaluation of benzoxazinones as HIV-1 reverse transcriptase inhibitors. Analogs of Efavirenz (SUSTIVA).
Bioorganic & medicinal chemistry letters 1999;9(22):3221-4.
1999: Mona Patel; James D Rodgers; RJ McHugh; BL Johnson; Beverly C Cordova; Ronald Klabe; Lee Bacheler; Susan Erickson-Viitanen; Soo S Ko
Unsymmetrical cyclic ureas as HIV-1 protease inhibitors: novel biaryl indazoles as P2/P2' substituents.
Bioorganic & medicinal chemistry letters 1999;9(22):3217-20.
1999: Mona Patel; Soo S Ko; RJ McHugh; Jay A Markwalder; A S Srivastava; Beverly C Cordova; Ronald Klabe; Susan Erickson-Viitanen; George L Trainor; Steven P Seitz
Synthesis and evaluation of analogs of Efavirenz (SUSTIVA) as HIV-1 reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry letters 1999;9(19):2805-10.
1998: James D Rodgers; Patrick Y S Lam; BL Johnson; H Wang; R Li; Y Ru; Soo S Ko; Steven P Seitz; George L Trainor; PS Anderson; Ronald Klabe; Lee Bacheler; Beverly C Cordova; Sena Garber; C Reid; Matthew R Wright; Chong-Hwan Chang; Susan Erickson-Viitanen
Design and selection of DMP 850 and DMP 851: the next generation of cyclic urea HIV protease inhibitors.
Chemistry & biology 1998;5(10):597-608.
1998: Gene C Ness; Dayami Lopez; CM Chambers; Z Zhao; D L Beach; Soo S Ko; J M Trzaskos
Effects of 15-oxa-32-vinyl-lanost-8-ene-3 beta,32 diol on the expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase and low density lipoprotein receptor in rat liver.
Archives of biochemistry and biophysics 1998;357(2):259-64.
1998: George V De Lucca; Ui Tae Kim; J Liang; Beverly C Cordova; Ronald Klabe; Sena Garber; Lee Bacheler; GN Lam; Matthew R Wright; Kelly Logue; Susan Erickson-Viitanen; Soo S Ko; George L Trainor
Nonsymmetric P2/P2' cyclic urea HIV protease inhibitors. Structure-activity relationship, bioavailability, and resistance profile of monoindazole-substituted P2 analogues.
Journal of medicinal chemistry 1998;41(13):2411-23.