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Hisataka Kobayashi

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Kohei Sano; Peter L Choyke; Takashi Ikegami; Kiminori Miyazaki; Takahito Nakajima; Yuya Ohuchi; Hisataka Kobayashi
Short PEG-Linkers Improve the Performance of Targeted, Activatable Monoclonal Antibody-Indocyanine Green Optical Imaging Probes.
Kohei Sano; Takahito Nakajima; Peter L Choyke; Hisataka Kobayashi
Markedly enhanced permeability and retention effects induced by photo-immunotherapy of tumors.
Rhonda C Kines; Hisataka Kobayashi; Peter L Choyke; Marcelino L Bernardo
Optical imaging of HPV infection in a murine model.

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All Publications

2013: Kohei Sano; Peter L Choyke; Takashi Ikegami; Kiminori Miyazaki; Takahito Nakajima; Yuya Ohuchi; Hisataka Kobayashi
Short PEG-Linkers Improve the Performance of Targeted, Activatable Monoclonal Antibody-Indocyanine Green Optical Imaging Probes.
Bioconjugate chemistry 2013;24(5):811-6.
2013: Kohei Sano; Takahito Nakajima; Peter L Choyke; Hisataka Kobayashi
Markedly enhanced permeability and retention effects induced by photo-immunotherapy of tumors.
ACS nano 2013;7(1):717-24.
2013: Rhonda C Kines; Hisataka Kobayashi; Peter L Choyke; Marcelino L Bernardo
Optical imaging of HPV infection in a murine model.
Methods in molecular biology (Clifton, N.J.) 2013;961():141-50.
2013: Nobuyuki Kosaka; Makoto Mitsunaga; Peter L Choyke; Hisataka Kobayashi
In vivo real-time lymphatic draining using quantum-dot optical imaging in mice.
Contrast media & molecular imaging 2013;8(1):96-100.
2012: Nakajima Takahitio; Kohei Sano; Peter L Choyke; Makoto Mitsunaga; Hisataka Kobayashi
Real-time monitoring of in vivo acute necrotic cancer cell death induced by near infrared photoimmunotherapy using fluorescence lifetime imaging.
Cancer research 2012;72(18):4622-8.
2012: Vinita M Alexander; Peter L Choyke; Nakajima Takahitio; Marcin Ptaszek; Kohei Sano; Zhanqian Yu; Hisataka Kobayashi
Galactosyl human serum albumin-NMP1 conjugate: a near infrared (NIR)-activatable fluorescence imaging agent to detect peritoneal ovarian cancer metastases.
Bioconjugate chemistry 2012;23(8):1671-9.
2012: Makoto Mitsunaga; Nakajima Takahitio; Kohei Sano; Peter L Choyke; Hisataka Kobayashi
Near-infrared theranostic photoimmunotherapy (PIT): repeated exposure of light enhances the effect of immunoconjugate.
Bioconjugate chemistry 2012;23(3):604-9.
2012: Nobuyuki Kosaka; Makoto Mitsunaga; Marcelino Bernardo; Peter L Choyke; Hisataka Kobayashi
MR and optical imaging of early micrometastases in lymph nodes: triple labeling with nano-sized agents yielding distinct signals.
Contrast media & molecular imaging 2012;7(2):247-53.
2012: Makoto Mitsunaga; Nakajima Takahitio; Kohei Sano; Peter L Choyke; Gabriela Kramer-Marek; Hisataka Kobayashi
Immediate in vivo target-specific cancer cell death after near infrared photoimmunotherapy.
BMC cancer 2012;12():345.
2012: Thomas E McCann; Nobuyuki Kosaka; Peter L Choyke; Hisataka Kobayashi
The use of fluorescent proteins for developing cancer-specific target imaging probes.
Methods in molecular biology (Clifton, N.J.) 2012;872():191-204.
2012: Kohei Sano; Peter L Choyke; Makoto Mitsunaga; Nakajima Takahitio; Hisataka Kobayashi
In vivo breast cancer characterization imaging using two monoclonal antibodies activatably labeled with near infrared fluorophores.
Breast cancer research : BCR 2012;14(2):R61.
2011: Makoto Mitsunaga; Mikako Ogawa; Lauren T Rosenblum; Peter L Choyke; Nobuyuki Kosaka; Hisataka Kobayashi
Cancer cell-selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules.
Nature medicine 2011;17(12):1685-91.
2011: Nobuyuki Kosaka; Michelle R Longmire; Makoto Mitsunaga; Peter L Choyke; Hisataka Kobayashi
Near infrared fluorescence-guided real-time endoscopic detection of peritoneal ovarian cancer nodules using intravenously injected indocyanine green.
International journal of cancer. Journal international du cancer 2011;129(7):1671-7.
2011: Hisataka Kobayashi; Michelle R Longmire; Mikako Ogawa; Peter L Choyke
Rational chemical design of the next generation of molecular imaging probes based on physics and biology: mixing modalities, colors and signals.
Chemical Society reviews 2011;40(9):4626-48.
2011: Nakajima Takahitio; Makoto Mitsunaga; Neil H Bander; Peter L Choyke; Warren D Heston; Hisataka Kobayashi
Targeted, activatable, in vivo fluorescence imaging of prostate-specific membrane antigen (PSMA) positive tumors using the quenched humanized J591 antibody-indocyanine green (ICG) conjugate.
Bioconjugate chemistry 2011;22(8):1700-5.
2011: Thomas E McCann; Makoto Mitsunaga; Baris Turkbey; Peter L Choyke; Nobuyuki Kosaka; Hisataka Kobayashi
Molecular imaging of tumor invasion and metastases: the role of MRI.
NMR in biomedicine 2011;24(6):561-8.
2011: Michelle R Longmire; Mikako Ogawa; Peter L Choyke; Hisataka Kobayashi
Biologically optimized nanosized molecules and particles: more than just size.
Bioconjugate chemistry 2011;22(6):993-1000.
2011: Makoto Mitsunaga; Nobuyuki Kosaka; Rhonda C Kines; Jeffrey N Roberts; Douglas Lowy; John T Schiller; Yasushige Ishihara; Akira Hasegawa; Peter L Choyke; Hisataka Kobayashi
In vivo longitudinal imaging of experimental human papillomavirus infection in mice with a multicolor fluorescence mini-endoscopy system.
Cancer prevention research (Philadelphia, Pa.) 2011;4(5):767-73.
2011: Lauren T Rosenblum; Peter L Choyke; Nobuyuki Kosaka; Makoto Mitsunaga; Hisataka Kobayashi
Optimizing quantitative in vivo fluorescence imaging with near-infrared quantum dots.
Contrast media & molecular imaging 2011;6(3):148-52.
2011: Lauren T Rosenblum; Peter L Choyke; Hisataka Kobayashi
Quantitative and specific molecular imaging of cancer with labeled engineered monoclonal antibody fragments.
Therapeutic delivery 2011;2(3):345-58.
2011: Nobuyuki Kosaka; Makoto Mitsunaga; Sukanta Bhattacharyya; Steven C Miller; Peter L Choyke; Hisataka Kobayashi
Self-illuminating in vivo lymphatic imaging using a bioluminescence resonance energy transfer quantum dot nano-particle.
Contrast media & molecular imaging 2011;6(1):55-9.
2010: Thomas E McCann; Nobuyuki Kosaka; Makoto Mitsunaga; Peter L Choyke; Jeffrey C Gildersleeve; Hisataka Kobayashi
Biodistribution and excretion of monosaccharide-albumin conjugates measured with in vivo near-infrared fluorescence imaging.
Bioconjugate chemistry 2010;21(10):1925-32.
2010: Lauren T Rosenblum; Nobuyuki Kosaka; Makoto Mitsunaga; Peter L Choyke; Hisataka Kobayashi
In vivo molecular imaging using nanomaterials: general in vivo characteristics of nano-sized reagents and applications for cancer diagnosis.
Molecular membrane biology 2010;27(7):274-85.
2010: Nobuyuki Kosaka; Thomas E McCann; Makoto Mitsunaga; Peter L Choyke; Hisataka Kobayashi
Real-time optical imaging using quantum dot and related nanocrystals.
Nanomedicine (London, England) 2010;5(5):765-76.
2010: Hisataka Kobayashi; Michelle R Longmire; Mikako Ogawa; Peter L Choyke; Satomi Kawamoto
Multiplexed imaging in cancer diagnosis: applications and future advances.
The lancet oncology 2010;11(6):589-95.
2010: Mikako Ogawa; Celeste A S Regino; Bernardo Marcelino; Mark Williams; Nobuyuki Kosaka; L Henry Bryant; Peter L Choyke; Hisataka Kobayashi
New nanosized biocompatible MR contrast agents based on lysine-dendri-graft macromolecules.
Bioconjugate chemistry 2010;21(5):955-60.
2010: Hisataka Kobayashi; Mikako Ogawa; Raphael Alford; Peter L Choyke; Yasuteru Urano
New strategies for fluorescent probe design in medical diagnostic imaging.
Chemical reviews 2010;110(5):2620-40.
2010: Mikako Ogawa; Nobuyuki Kosaka; Celeste A S Regino; Makoto Mitsunaga; Peter L Choyke; Hisataka Kobayashi
High sensitivity detection of cancer in vivo using a dual-controlled activation fluorescent imaging probe based on H-dimer formation and pH activation.
Molecular bioSystems 2010;6(5):888-93.
2010: Nobuyuki Kosaka; Mikako Ogawa; David S Paik; Chang H Paik; Peter L Choyke; Hisataka Kobayashi
Semiquantitative assessment of the microdistribution of fluorescence-labeled monoclonal antibody in small peritoneal disseminations of ovarian cancer.
Cancer science 2010;101(3):820-5.
2010: Celeste A S Regino; Mikako Ogawa; Raphael Alford; Karen J Wong; Noboyuki Kosaka; Mark Williams; Brian J Feild; Masatoshi Takahashi; Peter L Choyke; Hisataka Kobayashi
Two-step synthesis of galactosylated human serum albumin as a targeted optical imaging agent for peritoneal carcinomatosis.
Journal of medicinal chemistry 2010;53(4):1579-86.
2010: Raphael Alford; Mikako Ogawa; Moinuddin Hassan; Amir H Gandjbakhche; Peter L Choyke; Hisataka Kobayashi
Fluorescence lifetime imaging of activatable target specific molecular probes.
Contrast media & molecular imaging 2010;5(1):1-8.
2009: Richard T Lucarelli; Mikako Ogawa; Nobuyuki Kosaka; Baris Turkbey; Hisataka Kobayashi; Peter L Choyke
New approaches to lymphatic imaging.
Lymphatic research and biology 2009;7(4):205-14.
2009: Raphael Alford; Haley M Simpson; Josh Duberman; G Craig Hill; Mikako Ogawa; Celeste Regino; Hisataka Kobayashi; Peter L Choyke
Toxicity of organic fluorophores used in molecular imaging: literature review.
Molecular imaging 2009;8(6):341-54.
2009: Nobuyuki Kosaka; Mikako Ogawa; Noriko Sato; Peter L Choyke; Hisataka Kobayashi
In vivo real-time, multicolor, quantum dot lymphatic imaging.
The Journal of investigative dermatology 2009;129(12):2818-22.
2009: Gregory Ravizzini; Baris Turkbey; Tristan Barrett; Hisataka Kobayashi; Peter L Choyke
Nanoparticles in sentinel lymph node mapping.
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 2009;1(6):610-23.
2009: Mikako Ogawa; Celeste A S Regino; Jurgen Seidel; Michael V Green; Wenze Xi; Mark Williams; Nobuyuki Kosaka; Peter L Choyke; Hisataka Kobayashi
Dual-modality molecular imaging using antibodies labeled with activatable fluorescence and a radionuclide for specific and quantitative targeted cancer detection.
Bioconjugate chemistry 2009;20(11):2177-84.
2009: Nobuyuki Kosaka; Mikako Ogawa; Peter L Choyke; Hisataka Kobayashi
Clinical implications of near-infrared fluorescence imaging in cancer.
Future oncology (London, England) 2009;5(9):1501-11.
2009: Raphael Alford; Mikako Ogawa; Peter L Choyke; Hisataka Kobayashi
Molecular probes for the in vivo imaging of cancer.
Molecular bioSystems 2009;5(11):1279-91.
2009: Baris Turkbey; Hisataka Kobayashi; Mikako Ogawa; Marcelino Bernardo; Peter L Choyke
Imaging of tumor angiogenesis: functional or targeted?
AJR. American journal of roentgenology 2009;193(2):304-13.
2009: Mikako Ogawa; Nobuyuki Kosaka; Peter L Choyke; Hisataka Kobayashi
H-type dimer formation of fluorophores: a mechanism for activatable, in vivo optical molecular imaging.
ACS chemical biology 2009;4(7):535-46.
2009: Nobuyuki Kosaka; Mikako Ogawa; Peter L Choyke; Natasha Karassina; Cesear Corona; Mark McDougall; David T Lynch; Clifford C Hoyt; Richard Levenson; Georgyi V Los; Hisataka Kobayashi
In vivo stable tumor-specific painting in various colors using dehalogenase-based protein-tag fluorescent ligands.
Bioconjugate chemistry 2009;20(7):1367-74.
2009: Hisataka Kobayashi; Mikako Ogawa; Nobuyuki Kosaka; Peter L Choyke; Yasuteru Urano
Multicolor imaging of lymphatic function with two nanomaterials: quantum dot-labeled cancer cells and dendrimer-based optical agents.
Nanomedicine (London, England) 2009;4(4):411-9.
2009: Michelle Longmire; Nobuyuki Kosaka; Mikako Ogawa; Peter L Choyke; Hisataka Kobayashi
Multicolor in vivo targeted imaging to guide real-time surgery of HER2-positive micrometastases in a two-tumor coincident model of ovarian cancer.
Cancer science 2009;100(6):1099-104.
2009: Mikako Ogawa; Nobuyuki Kosaka; Michelle R Longmire; Yasuteru Urano; Peter L Choyke; Hisataka Kobayashi
Fluorophore-quencher based activatable targeted optical probes for detecting in vivo cancer metastases.
Molecular pharmaceutics 2009;6(2):386-95.
2009: Mikako Ogawa; Nobuyuki Kosaka; Peter L Choyke; Hisataka Kobayashi
In vivo molecular imaging of cancer with a quenching near-infrared fluorescent probe using conjugates of monoclonal antibodies and indocyanine green.
Cancer research 2009;69(4):1268-72.
2009: Nobuyuki Kosaka; Mikako Ogawa; Michelle R Longmire; Peter L Choyke; Hisataka Kobayashi
Multi-targeted multi-color in vivo optical imaging in a model of disseminated peritoneal ovarian cancer.
Journal of biomedical optics 2009;14(1):014023.
2009: Tristan Barrett; Gregory Ravizzini; Peter L Choyke; Hisataka Kobayashi
Dendrimers in medical nanotechnology.
IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society 2009;28(1):12-22.
2009: Mikako Ogawa; Celeste A S Regino; Peter L Choyke; Hisataka Kobayashi
In vivo target-specific activatable near-infrared optical labeling of humanized monoclonal antibodies.
Molecular cancer therapeutics 2009;8(1):232-9.
2009: Mikako Ogawa; Nobuyuki Kosaka; Peter L Choyke; Hisataka Kobayashi
Tumor-specific detection of an optically targeted antibody combined with a quencher-conjugated neutravidin "quencher-chaser": a dual "quench and chase" strategy to improve target to nontarget ratios for molecular imaging of cancer.
Bioconjugate chemistry 2009;20(1):147-54.
2008: Michelle Longmire; Peter L Choyke; Hisataka Kobayashi
Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats.
Nanomedicine (London, England) 2008;3(5):703-17.
2008: Michelle R Longmire; Mikako Ogawa; Yukihiro Hama; Nobuyuki Kosaka; Celeste A S Regino; Peter L Choyke; Hisataka Kobayashi
Determination of optimal rhodamine fluorophore for in vivo optical imaging.
Bioconjugate chemistry 2008;19(8):1735-42.
2008: Michelle Longmire; Peter L Choyke; Hisataka Kobayashi
Dendrimer-based contrast agents for molecular imaging.
Current topics in medicinal chemistry 2008;8(14):1180-6.
2007: Yoshinori Koyama; Tristan Barrett; Yukihiro Hama; Gregory Ravizzini; Peter L Choyke; Hisataka Kobayashi
In vivo molecular imaging to diagnose and subtype tumors through receptor-targeted optically labeled monoclonal antibodies.
Neoplasia (New York, N.Y.) 2007;9(12):1021-9.
2007: Tristan Barrett; Yoshinori Koyama; Yukihiro Hama; Gregory Ravizzini; In Soo Shin; Beom-Su Jang; Chang H Paik; Yasuteru Urano; Peter L Choyke; Hisataka Kobayashi
In vivo diagnosis of epidermal growth factor receptor expression using molecular imaging with a cocktail of optically labeled monoclonal antibodies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(22 Pt 1):6639-48.
2007: Hisataka Kobayashi; Yoshinori Koyama; Tristan Barrett; Yukihiro Hama; Celeste A S Regino; In Soo Shin; Beom-Su Jang; Nhat Le; Chang H Paik; Peter L Choyke; Yasuteru Urano
Multimodal nanoprobes for radionuclide and five-color near-infrared optical lymphatic imaging.
ACS nano 2007;1(4):258-64.
2007: Yukihiro Hama; Yasuteru Urano; Yoshinori Koyama; Andrew J Gunn; Peter L Choyke; Hisataka Kobayashi
A self-quenched galactosamine-serum albumin-rhodamineX conjugate: a "smart" fluorescent molecular imaging probe synthesized with clinically applicable material for detecting peritoneal ovarian cancer metastases.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(21):6335-43.
2007: Andrew J Gunn; Yukihiro Hama; Yoshinori Koyama; Elise C Kohn; Peter L Choyke; Hisataka Kobayashi
Targeted optical fluorescence imaging of human ovarian adenocarcinoma using a galactosyl serum albumin-conjugated fluorophore.
Cancer science 2007;98(11):1727-33.
2007: Yukihiro Hama; Yoshinori Koyama; Yasuteru Urano; Peter L Choyke; Hisataka Kobayashi
Two-color lymphatic mapping using Ig-conjugated near infrared optical probes.
The Journal of investigative dermatology 2007;127(10):2351-6.
2007: Yukihiro Hama; Yasuteru Urano; Yoshinori Koyama; Peter L Choyke; Hisataka Kobayashi
D-galactose receptor-targeted in vivo spectral fluorescence imaging of peritoneal metastasis using galactosamin-conjugated serum albumin-rhodamine green.
Journal of biomedical optics 2007;12(5):051501.
2007: Heng Xu; Celeste A S Regino; Yoshinori Koyama; Yukihiro Hama; Andrew J Gunn; Marcelino Bernardo; Hisataka Kobayashi; Peter L Choyke; Martin W Brechbiel
Preparation and preliminary evaluation of a biotin-targeted, lectin-targeted dendrimer-based probe for dual-modality magnetic resonance and fluorescence imaging.
Bioconjugate chemistry 2007;18(5):1474-82.
2007: Heng Xu; Celeste A S Regino; Marcelino Bernardo; Yoshinori Koyama; Hisataka Kobayashi; Peter L Choyke; Martin W Brechbiel
Toward improved syntheses of dendrimer-based magnetic resonance imaging contrast agents: new bifunctional diethylenetriaminepentaacetic acid ligands and nonaqueous conjugation chemistry.
Journal of medicinal chemistry 2007;50(14):3185-93.
2007: Hisataka Kobayashi; Yukihiro Hama; Yoshinori Koyama; Tristan Barrett; Celeste A S Regino; Yasuteru Urano; Peter L Choyke
Simultaneous multicolor imaging of five different lymphatic basins using quantum dots.
Nano letters 2007;7(6):1711-6.
2007: Yoshinori Koyama; Yukihiro Hama; Yasuteru Urano; Dao Nguyen; Peter L Choyke; Hisataka Kobayashi
Spectral fluorescence molecular imaging of lung metastases targeting HER2/neu.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(10):2936-45.
2007: Yukihiro Hama; Yoshinori Koyama; Peter L Choyke; Hisataka Kobayashi
Two-color in vivo dynamic contrast-enhanced pharmacokinetic imaging.
Journal of biomedical optics 2007;12(3):034016.
2007: Yukihiro Hama; Yoshinori Koyama; Yasuteru Urano; Peter L Choyke; Hisataka Kobayashi
Simultaneous two-color spectral fluorescence lymphangiography with near infrared quantum dots to map two lymphatic flows from the breast and the upper extremity.
Breast cancer research and treatment 2007;103(1):23-8.
2007: Yukihiro Hama; Yasuteru Urano; Yoshinori Koyama; Peter L Choyke; Hisataka Kobayashi
Activatable fluorescent molecular imaging of peritoneal metastases following pretargeting with a biotinylated monoclonal antibody.
Cancer research 2007;67(8):3809-17.
2007: Yoshinori Koyama; Vladimir S Talanov; Marcelino Bernardo; Yukihiro Hama; Celeste A S Regino; Martin W Brechbiel; Peter L Choyke; Hisataka Kobayashi
A dendrimer-based nanosized contrast agent dual-labeled for magnetic resonance and optical fluorescence imaging to localize the sentinel lymph node in mice.
Journal of magnetic resonance imaging : JMRI 2007;25(4):866-71.
2007: Yukihiro Hama; Yasuteru Urano; Yoshinori Koyama; Mako Kamiya; Marcelino Bernardo; Ronald S Paik; In Soo Shin; Chang H Paik; Peter L Choyke; Hisataka Kobayashi
A target cell-specific activatable fluorescence probe for in vivo molecular imaging of cancer based on a self-quenched avidin-rhodamine conjugate.
Cancer research 2007;67(6):2791-9.
2007: Yukihiro Hama; Yoshinori Koyama; Marcelino Bernardo; Peter L Choyke; Hisataka Kobayashi
Spectral near-infrared fluorescence imaging of curved surfaces using projection reconstruction algorithms.
Contrast media & molecular imaging 2007;2(2):82-7.
2007: Hisataka Kobayashi
[Molecular imaging; current status and future prospects in USA].
Nihon rinsho. Japanese journal of clinical medicine 2007;65(2):204-10.
2007: Yukihiro Hama; Marcelino Bernardo; Celeste A S Regino; Yoshinori Koyama; Martin W Brechbiel; Murali K Cherukuri; Peter L Choyke; Hisataka Kobayashi
MR lymphangiography using dendrimer-based contrast agents: a comparison at 1.5T and 3.0T.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2007;57(2):431-6.
2006: Tristan Barrett; Hisataka Kobayashi; Martin W Brechbiel; Peter L Choyke
Macromolecular MRI contrast agents for imaging tumor angiogenesis.
European journal of radiology 2006;60(3):353-66.
2006: Tristan Barrett; Peter L Choyke; Hisataka Kobayashi
Imaging of the lymphatic system: new horizons.
Contrast media & molecular imaging 2006;1(6):230-45.
2006: Yukihiro Hama; Yasuteru Urano; Yoshinori Koyama; Marcelino Bernardo; Peter L Choyke; Hisataka Kobayashi
A comparison of the emission efficiency of four common green fluorescence dyes after internalization into cancer cells.
Bioconjugate chemistry 2006;17(6):1426-31.
2006: Yukihiro Hama; Yasuteru Urano; Yoshinori Koyama; Peter L Choyke; Hisataka Kobayashi
Targeted optical imaging of cancer cells using lectin-binding BODIPY conjugated avidin.
Biochemical and biophysical research communications 2006;348(3):807-13.
2006: Yukihiro Hama; Yasuteru Urano; Yoshinori Koyama; Mako Kamiya; Marcelino Bernardo; Ronald S Paik; Murali K Cherukuri; Peter L Choyke; Hisataka Kobayashi
In vivo spectral fluorescence imaging of submillimeter peritoneal cancer implants using a lectin-targeted optical agent.
Neoplasia (New York, N.Y.) 2006;8(7):607-12.
2006: Vladimir S Talanov; Celeste A S Regino; Hisataka Kobayashi; Marcelino Bernardo; Peter L Choyke; Martin W Brechbiel
Dendrimer-based nanoprobe for dual modality magnetic resonance and fluorescence imaging.
Nano letters 2006;6(7):1459-63.
2006: Hisataka Kobayashi; Satomi Kawamoto; Marcelino Bernardo; Martin W Brechbiel; Michael V Knopp; Peter L Choyke
Delivery of gadolinium-labeled nanoparticles to the sentinel lymph node: comparison of the sentinel node visualization and estimations of intra-nodal gadolinium concentration by the magnetic resonance imaging.
Journal of controlled release : official journal of the Controlled Release Society 2006;111(3):343-51.
2006: Peter L Choyke; Hisataka Kobayashi
Functional magnetic resonance imaging of the kidney using macromolecular contrast agents.
Abdominal imaging 2006;31(2):224-31.
2006: James W Dear; Hisataka Kobayashi; Martin W Brechbiel; robert star
Imaging acute renal failure with polyamine dendrimer-based MRI contrast agents.
Nephron. Clinical practice 2006;103(2):c45-9.
2005: Hisataka Kobayashi; Martin W Brechbiel
Nano-sized MRI contrast agents with dendrimer cores.
Advanced drug delivery reviews 2005;57(15):2271-86.
2005: Hisataka Kobayashi; Satomi Kawamoto; Martin W Brechbiel; Marcelino Bernardo; Noriko Sato; Thomas Waldmann; Yutaka Tagaya; Peter L Choyke
Detection of lymph node involvement in hematologic malignancies using micromagnetic resonance lymphangiography with a gadolinum-labeled dendrimer nanoparticle.
Neoplasia (New York, N.Y.) 2005;7(11):984-91.
2005: James W Dear; Hisataka Kobayashi; Sang-Kyung Jo; Mikaela K Holly; Xuzhen Hu; Peter S T Yuen; Martin W Brechbiel; robert star
Dendrimer-enhanced MRI as a diagnostic and prognostic biomarker of sepsis-induced acute renal failure in aged mice.
Kidney international 2005;67(6):2159-67.
2005: Makoto Sugaya; Takahiro Watanabe; Aparche Yang; Matthew F Starost; Hisataka Kobayashi; April M Atkins; Debra L Borris; Elisabeth A Hanan; Daniel Schimel; Mark A Bryant; Nicole Roberts; Mihaela Skobe; Katherine A Staskus; Philipp Kaldis; Andrew Blauvelt
Lymphatic dysfunction in transgenic mice expressing KSHV k-cyclin under the control of the VEGFR-3 promoter.
Blood 2005;105(6):2356-63.
2005: Milliam L Kataoka; Kaori Togashi; Toshihide Yamaoka; Takashi Koyama; Hiroyuki Ueda; Hisataka Kobayashi; Mahbubur Rahman; Toshihiro Higuchi; Shingo Fujii
Posterior cul-de-sac obliteration associated with endometriosis: MR imaging evaluation.
Radiology 2005;234(3):815-23.
2005: Hisataka Kobayashi; Sigrid Dubois; Noriko Sato; Helen Sabzevari; Yoshio Sakai; Thomas Waldmann; Yutaka Tagaya
Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillance.
Blood 2005;105(2):721-7.
2004: Hisataka Kobayashi; Martin W Brechbiel
Dendrimer-based nanosized MRI contrast agents.
Current pharmaceutical biotechnology 2004;5(6):539-49.
2004: Hisataka Kobayashi; Koen Reijnders; Sean English; Alexander T Yordanov; Diane E Milenic; Anastasia L Sowers; Deborah Citrin; Murali K Cherukuri; Thomas Waldmann; James B Mitchell; Martin W Brechbiel
Application of a macromolecular contrast agent for detection of alterations of tumor vessel permeability induced by radiation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(22):7712-20.
2004: Hisataka Kobayashi; Sang-Kyung Jo; Satomi Kawamoto; Hideo Yasuda; Xuzhen Hu; Michael V Knopp; Martin W Brechbiel; Peter L Choyke; robert star
Polyamine dendrimer-based MRI contrast agents for functional kidney imaging to diagnose acute renal failure.
Journal of magnetic resonance imaging : JMRI 2004;20(3):512-8.
2004: Hisataka Kobayashi; Satomi Kawamoto; Yoshio Sakai; Peter L Choyke; robert star; Martin W Brechbiel; Noriko Sato; Yutaka Tagaya; John C Morris; Thomas Waldmann
Lymphatic drainage imaging of breast cancer in mice by micro-magnetic resonance lymphangiography using a nano-size paramagnetic contrast agent.
Journal of the National Cancer Institute 2004;96(9):703-8.
2004: Hisataka Kobayashi; Satomi Kawamoto; Martin W Brechbiel; Sang-Kyung Jo; Xuzhen Hu; Tianxin Yang; Bhalchandra A Diwan; Thomas Waldmann; Jurgen Schnermann; Peter L Choyke; robert star
Micro-MRI methods to detect renal cysts in mice.
Kidney international 2004;65(4):1511-6.
2004: Marcelo Mamede; Tsuneo Saga; Takayoshi Ishimori; Tatsuya Higashi; Noriko Sato; Hisataka Kobayashi; Martin W Brechbiel; Junji Konishi
Hepatocyte targeting of 111In-labeled oligo-DNA with avidin or avidin-dendrimer complex.
Journal of controlled release : official journal of the Controlled Release Society 2004;95(1):133-41.
2004: Raya Mandler; Hisataka Kobayashi; Ella R Hinson; Martin W Brechbiel; Thomas Waldmann
Herceptin-geldanamycin immunoconjugates: pharmacokinetics, biodistribution, and enhanced antitumor activity.
Cancer research 2004;64(4):1460-7.
2003: Asako Nakai; Kaori Togashi; Toshihide Yamaoka; Toshitaka Fujiwara; Hiroyuki Ueda; Takashi Koyama; Hisataka Kobayashi; Tatsuo Kagimura; Shingo Fujii; Junji Konishi
Uterine peristalsis shown on cine MR imaging using ultrafast sequence.
Journal of magnetic resonance imaging : JMRI 2003;18(6):726-33.
2003: Hisataka Kobayashi; Satomi Kawamoto; Peter L Choyke; Noriko Sato; Michael V Knopp; robert star; Thomas Waldmann; Yutaka Tagaya; Martin W Brechbiel
Comparison of dendrimer-based macromolecular contrast agents for dynamic micro-magnetic resonance lymphangiography.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2003;50(4):758-66.
2003: Marcelo Mamede; Tsuneo Saga; Hisataka Kobayashi; Takayoshi Ishimori; Tatsuya Higashi; Noriko Sato; Martin W Brechbiel; Junji Konishi
Radiolabeling of avidin with very high specific activity for internal radiation therapy of intraperitoneally disseminated tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(10 Pt 1):3756-62.
2003: Hisataka Kobayashi; Satomi Kawamoto; robert star; Thomas Waldmann; Martin W Brechbiel; Peter L Choyke
Activated clearance of a biotinylated macromolecular MRI contrast agent from the blood pool using an avidin chase.
Bioconjugate chemistry 2003;14(5):1044-7.
2003: Yuji Nakamoto; Tsuneo Saga; Tatsuya Higashi; Takayoshi Ishimori; Hisataka Kobayashi; Koichi Ishizu; Noriko Sato; Marcelo Mamede; Harumi Sakahara; Masayuki Imamura; Junji Konishi
Optimal scan time for evaluating pancreatic disease with positron emission tomography using F-18-fluorodeoxyglucose.
Annals of nuclear medicine 2003;17(5):421-6.
2003: Sang-Kyung Jo; Xuzhen Hu; Hisataka Kobayashi; Martin Lizak; Takehiko Miyaji; Alan Koretsky; robert star
Detection of inflammation following renal ischemia by magnetic resonance imaging.
Kidney international 2003;64(1):43-51.
2003: Marcelo Mamede; Tsuneo Saga; Takayoshi Ishimori; Yuji Nakamoto; Noriko Sato; Tatsuya Higashi; Takahiro Mukai; Hisataka Kobayashi; Junji Konishi
Differential uptake of (18)F-fluorodeoxyglucose by experimental tumors xenografted into immunocompetent and immunodeficient mice and the effect of immunomodification.
Neoplasia (New York, N.Y.) 2003;5(2):179-83.
2003: Hisataka Kobayashi; Satomi Kawamoto; Sang-Kyung Jo; Henry L Bryant; Martin W Brechbiel; robert star
Macromolecular MRI contrast agents with small dendrimers: pharmacokinetic differences between sizes and cores.
Bioconjugate chemistry 2003;14(2):388-94.
2003: Hisataka Kobayashi; Satomi Kawamoto; robert star; Thomas Waldmann; Yutaka Tagaya; Martin W Brechbiel
Micro-magnetic resonance lymphangiography in mice using a novel dendrimer-based magnetic resonance imaging contrast agent.
Cancer research 2003;63(2):271-6.
2003: Hisataka Kobayashi; Martin W Brechbiel
Dendrimer-based macromolecular MRI contrast agents: characteristics and application.
Molecular imaging 2003;2(1):1-10.
2002: Insook Kim; Hisataka Kobayashi; Tae M Yoo; Meyong-kon Kim; Nhat Le; Eui-sik Han; Qing-Cheng Wang; Ira Pastan; Jorge Carrasquillo; Chang H Paik
Lowering of pI by acylation improves the renal uptake of 99mTc-labeled anti-Tac dsFv: effect of different acylating reagents.
Nuclear medicine and biology 2002;29(8):795-801.
2002: Hisataka Kobayashi; Tsuneo Saga; Satomi Kawamoto; Noriko Sato; Akira Hiraga; Takayoshi Ishimori; Junji Konishi; Kaori Togashi; Martin W Brechbiel
Dynamic micro-MRI of liver micrometastasis with a novel liver macromolecular MR contrast agent DAB-Am64-(1B4M-Gd)64.
Academic radiology 2002;9 Suppl 2():S452-4.
2002: Raya Mandler; Hisataka Kobayashi; Marie Y Davis; Thomas Waldmann; Martin W Brechbiel
Modifications in synthesis strategy improve the yield and efficacy of geldanamycin-herceptin immunoconjugates.
Bioconjugate chemistry 2002;13(4):786-91.
2002: Hisataka Kobayashi; Satomi Kawamoto; Sang-Kyung Jo; Noriko Sato; Tsuneo Saga; Akira Hiraga; Junji Konishi; Susan Hu; Kaori Togashi; Martin W Brechbiel; robert star
Renal tubular damage detected by dynamic micro-MRI with a dendrimer-based magnetic resonance contrast agent.
Kidney international 2002;61(6):1980-5.
2002: Takayoshi Ishimori; Tsuneo Saga; Marcelo Mamede; Hisataka Kobayashi; Tatsuya Higashi; Yuji Nakamoto; Noriko Sato; Junji Konishi
Increased (18)F-FDG uptake in a model of inflammation: concanavalin A-mediated lymphocyte activation.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2002;43(5):658-63.
2002: Meyoung-Kon Kim; Hyeh-Jean Jeong; Chih-Hao K Kao; Zhengsheng Yao; David S Paik; Jae-Eun Pie; Hisataka Kobayashi; Thomas Waldmann; Jorge Carrasquillo; Chang H Paik
Improved renal clearance and tumor targeting of 99mTc-labeled anti-Tac monoclonal antibody Fab by chemical modifications.
Nuclear medicine and biology 2002;29(2):139-46.
2001: Hisataka Kobayashi; Satomi Kawamoto; Tsuneo Saga; Noriko Sato; Akira Hiraga; Junji Konishi; Kaori Togashi; Martin W Brechbiel
Micro-MR angiography of normal and intratumoral vessels in mice using dedicated intravascular MR contrast agents with high generation of polyamidoamine dendrimer core: reference to pharmacokinetic properties of dendrimer-based MR contrast agents.
Journal of magnetic resonance imaging : JMRI 2001;14(6):705-13.
2001: Noriko Sato; Hisataka Kobayashi; Akira Hiraga; Tsuneo Saga; Kaori Togashi; Junji Konishi; Martin W Brechbiel
Pharmacokinetics and enhancement patterns of macromolecular MR contrast agents with various sizes of polyamidoamine dendrimer cores.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2001;46(6):1169-73.
2001: Noriko Sato; Hisataka Kobayashi; Tsuneo Saga; Yuji Nakamoto; Takayoshi Ishimori; Kaori Togashi; Yasuhisa Fujibayashi; Junji Konishi; Martin W Brechbiel
Tumor targeting and imaging of intraperitoneal tumors by use of antisense oligo-DNA complexed with dendrimers and/or avidin in mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(11):3606-12.
2001: Toshihiko Masui; Ryo Hosotani; Shoichiro Tsuji; Yoshiharu Miyamoto; S Yasuda; Jyun Ida; Sanae Nakajima; Michiya Kawaguchi; Hisataka Kobayashi; Masayuki Koizumi; Eiji Toyoda; Sidhartha S Tulachan; Shigeki Arii; Ryuichiro Doi; Masayuki Imamura
Expression of METH-1 and METH-2 in pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(11):3437-43.
2001: Hisataka Kobayashi; Satomi Kawamoto; Tsuneo Saga; Noriko Sato; Akira Hiraga; Takayoshi Ishimori; Y Akita; Marcelo Mamede; Junji Konishi; Kaori Togashi; Martin W Brechbiel
Novel liver macromolecular MR contrast agent with a polypropylenimine diaminobutyl dendrimer core: comparison to the vascular MR contrast agent with the polyamidoamine dendrimer core.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2001;46(4):795-802.
2001: Hisataka Kobayashi; Satomi Kawamoto; Tsuneo Saga; Noriko Sato; Akira Hiraga; Takayoshi Ishimori; Junji Konishi; Kaori Togashi; Martin W Brechbiel
Positive effects of polyethylene glycol conjugation to generation-4 polyamidoamine dendrimers as macromolecular MR contrast agents.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2001;46(4):781-8.
2001: Hisataka Kobayashi; Noriko Sato; Satomi Kawamoto; Tsuneo Saga; Akira Hiraga; Takayoshi Ishimori; Junji Konishi; Kaori Togashi; Martin W Brechbiel
3D MR angiography of intratumoral vasculature using a novel macromolecular MR contrast agent.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2001;46(3):579-85.
2001: Hisataka Kobayashi; Noriko Sato; Satomi Kawamoto; Tsuneo Saga; Akira Hiraga; Takayoshi Ishimori; Junji Konishi; Kaori Togashi; Martin W Brechbiel
Novel intravascular macromolecular MRI contrast agent with generation-4 polyamidoamine dendrimer core: accelerated renal excretion with coinjection of lysine.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2001;46(3):457-64.
2001: Yoshiharu Miyamoto; Ryo Hosotani; Ryuichiro Doi; Michihiko Wada; Jyun Ida; Shoichiro Tsuji; Michiya Kawaguchi; Sanae Nakajima; Hisataka Kobayashi; Toshihiko Masui; Masayuki Imamura
Interleukin-6 inhibits radiation induced apoptosis in pancreatic cancer cells.
Anticancer research 2001;21(4A):2449-56.
2001: Hisataka Kobayashi; Satomi Kawamoto; Tsuneo Saga; Noriko Sato; Takayoshi Ishimori; Junji Konishi; Koji Ono; Kaori Togashi; Martin W Brechbiel
Avidin-dendrimer-(1B4M-Gd)(254): a tumor-targeting therapeutic agent for gadolinium neutron capture therapy of intraperitoneal disseminated tumor which can be monitored by MRI.
Bioconjugate chemistry 2001;12(4):587-93.
2001: Tsuneo Saga; Harumi Sakahara; Yuji Nakamoto; Noriko Sato; Takayoshi Ishimori; Marcelo Mamede; Hisataka Kobayashi; Shin-Ichiro Masunaga; K Sasai; M Kuroki; Junji Konishi
Enhancement of the therapeutic outcome of radio-immunotherapy by combination with whole-body mild hyperthermia.
European journal of cancer (Oxford, England : 1990) 2001;37(11):1429-34.
2001: Hisataka Kobayashi; Tsuneo Saga; Satomi Kawamoto; Noriko Sato; Akira Hiraga; Takayoshi Ishimori; Junji Konishi; Kaori Togashi; Martin W Brechbiel
Dynamic micro-magnetic resonance imaging of liver micrometastasis in mice with a novel liver macromolecular magnetic resonance contrast agent DAB-Am64-(1B4M-Gd)(64).
Cancer research 2001;61(13):4966-70.
2001: Hisataka Kobayashi; Noriko Sato; Akira Hiraga; Tsuneo Saga; Yuji Nakamoto; H Ueda; Junji Konishi; Kaori Togashi; Martin W Brechbiel
3D-micro-MR angiography of mice using macromolecular MR contrast agents with polyamidoamine dendrimer core with reference to their pharmacokinetic properties.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2001;45(3):454-60.
2001: Hisataka Kobayashi; Noriko Sato; Satomi Kawamoto; Tsuneo Saga; Akira Hiraga; T L Haque; Takayoshi Ishimori; Junji Konishi; Kaori Togashi; Martin W Brechbiel
Comparison of the macromolecular MR contrast agents with ethylenediamine-core versus ammonia-core generation-6 polyamidoamine dendrimer.
Bioconjugate chemistry 2001;12(1):100-7.
2000: Yuji Nakamoto; Tsuneo Saga; Takashi Misaki; Hisataka Kobayashi; Noriko Sato; Takayoshi Ishimori; Shinji Kosugi; Harumi Sakahara; Junji Konishi
Establishment and characterization of a breast cancer cell line expressing Na+/I- symporters for radioiodide concentrator gene therapy.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2000;41(11):1898-904.
2000: Hisataka Kobayashi; Noriko Sato; Tsuneo Saga; Yuji Nakamoto; Takayoshi Ishimori; S Toyama; Kaori Togashi; Junji Konishi; Martin W Brechbiel
Monoclonal antibody-dendrimer conjugates enable radiolabeling of antibody with markedly high specific activity with minimal loss of immunoreactivity.
European journal of nuclear medicine 2000;27(9):1334-9.
2000: Takatomo Koshiba; Ryo Hosotani; Yoshiharu Miyamoto; Jyun Ida; Shoichiro Tsuji; Sanae Nakajima; Michiya Kawaguchi; Hisataka Kobayashi; Ryuichiro Doi; Toshiyuki Hori; Nobutaka Fujii; Masayuki Imamura
Expression of stromal cell-derived factor 1 and CXCR4 ligand receptor system in pancreatic cancer: a possible role for tumor progression.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(9):3530-5.
2000: Hisataka Kobayashi; Jorge Carrasquillo; Chang H Paik; Thomas Waldmann; Yutaka Tagaya
Differences of biodistribution, pharmacokinetics, and tumor targeting between interleukins 2 and 15.
Cancer research 2000;60(13):3577-83.
2000: Hisataka Kobayashi; C H Kao; Robert J Kreitman; Nhat Le; Meyoung-Kon Kim; Martin W Brechbiel; Chang H Paik; Ira Pastan; Jorge Carrasquillo
Pharmacokinetics of 111In- and 125I-labeled antiTac single-chain Fv recombinant immunotoxin.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2000;41(4):755-62.
2000: BF Sun; Hisataka Kobayashi; Nhat Le; Tae M Yoo; D Drumm; Chang H Paik; J G McAfee; Jorge Carrasquillo
Effects of insulinlike growth factor binding proteins on insulinlike growth factor-I biodistribution in tumor-bearing nude mice.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2000;41(2):318-26.
2000: Michiya Kawaguchi; Ryo Hosotani; Masafumi Kogire; Jyun Ida; Ryuichiro Doi; Takatomo Koshiba; Yoshiharu Miyamoto; Shoichiro Tsuji; Sanae Nakajima; Hisataka Kobayashi; Toshihiko Masui; Masayuki Imamura
Auto-induction and growth stimulatory effect of betacellulin in human pancreatic cancer cells.
International journal of oncology 2000;16(1):37-41.
1999: Hisataka Kobayashi; BF Sun; Tae M Yoo; Nhat Le; Meyoung-Kon Kim; Chang H Paik; Ira Pastan; Thomas Waldmann; Jorge Carrasquillo
Methods to avoid adverse effect of circulating antigen on biodistribution of 125I-labeled antiTac dsFv: preinjection of intact antibody versus clearance of antigen with adivin-biotin system.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1999;40(8):1381-91.
1999: IS Kim; Tae M Yoo; Hisataka Kobayashi; Meyoung-Kon Kim; Nhat Le; Qing-Cheng Wang; Ira Pastan; Jorge Carrasquillo; Chang H Paik
Chemical modification to reduce renal uptake of disulfide-bonded variable region fragment of anti-Tac monoclonal antibody labeled with 99mTc.
Bioconjugate chemistry 1999;10(3):447-53.
1999: Hisataka Kobayashi; IS Kim; D Drumm; Meyoung-Kon Kim; David S Paik; Nhat Le; Thomas Waldmann; Jorge Carrasquillo; Chang H Paik
Favorable effects of glycolate conjugation on the biodistribution of humanized antiTac Fab fragment.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1999;40(5):837-45.
1999: Hisataka Kobayashi; Nhat Le; IS Kim; Meyoung-Kon Kim; Jae-Eun Pie; D Drumm; David S Paik; Thomas Waldmann; Chang H Paik; Jorge Carrasquillo
The pharmacokinetic characteristics of glycolated humanized anti-Tac Fabs are determined by their isoelectric points.
Cancer research 1999;59(2):422-30.
1999: M Kim; Jurgen Seidel; Nhat Le; IS Kim; Tae M Yoo; C Barker; Hisataka Kobayashi; Michael V Green; Jorge Carrasquillo; Chang H Paik
Evaluation of 99mTc-mercaptoacetyltriglycine-biocytin as a new hepatobiliary imaging agent in mice coinjected with bilirubin.
Nuclear medicine and biology 1999;26(1):43-9.
1999: Hisataka Kobayashi; Carl Wu; M K Kim; Chang H Paik; Jorge Carrasquillo; Martin W Brechbiel
Evaluation of the in vivo biodistribution of indium-111 and yttrium-88 labeled dendrimer-1B4M-DTPA and its conjugation with anti-Tac monoclonal antibody.
Bioconjugate chemistry 1999;10(1):103-11.
1998: Meyoung-Kon Kim; Byoung J Song; Jurgen Seidel; Y Soh; Kyu-Shik Jeong; IS Kim; Hisataka Kobayashi; Michael V Green; Jorge Carrasquillo; Chang H Paik
Use of 99mTc-mercaptoacetyltriglycine (MAG3)-biocytin hepatobiliary scintigraphy to study the protective effect of a synthetic enzyme inhibitor on acute hepatotoxicity in mice.
Nuclear medicine and biology 1998;25(6):561-8.
1998: Z Yao; M Zhang; Harumi Sakahara; Tsuneo Saga; Hisataka Kobayashi; Yuji Nakamoto; S Toyama; Junji Konishi
Increased streptavidin uptake in tumors pretargeted with biotinylated antibody using a conjugate of streptavidin-fab fragment.
Nuclear medicine and biology 1998;25(6):557-60.
1998: Hisataka Kobayashi; Eui-sik Han; IS Kim; Nhat Le; V Rajagopal; Robert J Kreitman; Ira Pastan; Chang H Paik; Jorge Carrasquillo
Similarities in the biodistribution of iodine-labeled anti-Tac single-chain disulfide-stabilized Fv fragment and anti-Tac disulfide-stabilized Fv fragment.
Nuclear medicine and biology 1998;25(4):387-93.
1998: Hisataka Kobayashi; Chuanchu Wu; Tae M Yoo; BF Sun; D Drumm; Ira Pastan; Chang H Paik; Otto A Gansow; Jorge Carrasquillo; Martin W Brechbiel
Evaluation of the in vivo biodistribution of yttrium-labeled isomers of CHX-DTPA-conjugated monoclonal antibodies.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1998;39(5):829-36.
1998: Hisataka Kobayashi; BF Sun; Eui-sik Han; Meyoung-Kon Kim; Nhat Le; Qing-Cheng Wang; David L Nelson; Ira Pastan; Thomas Waldmann; Chang H Paik; Jorge Carrasquillo
Epitope blocking: positive and negative effects on the biodistribution of 125I-labeled anti-Tac disulfide-stabilized Fv fragment of two antibodies against different epitopes of the circulating antigen.
Japanese journal of cancer research : Gann 1998;89(4):436-44.
1997: Hisataka Kobayashi; Chohei Shigeno; Harumi Sakahara; T Yamamoto; M Hosono; Ryota Fujimoto; Junji Konishi
Three phase 99Tcm (V)DMSA scintigraphy in Paget's disease: an indicator of pamidronate effect.
The British journal of radiology 1997;70(838):1056-9.
1997: Chuanchu Wu; Hisataka Kobayashi; B Sun; Tae M Yoo; Chang H Paik; Otto A Gansow; Jorge Carrasquillo; Ira Pastan; Martin W Brechbiel
Stereochemical influence on the stability of radio-metal complexes in vivo. Synthesis and evaluation of the four stereoisomers of 2-(p-nitrobenzyl)-trans-CyDTPA.
Bioorganic & medicinal chemistry 1997;5(10):1925-34.
1997: M Hosono; Hisataka Kobayashi; Ryota Fujimoto; K Tsutsui; Y Kotoura; Tadao Tsuboyama; H Hayashi; Tetsuya Nakamura; Junji Konishi
MR appearance of parasymphseal insufficiency fractures of the os pubis.
Skeletal radiology 1997;26(9):525-8.
1997: Yuji Nakamoto; Harumi Sakahara; Hisataka Kobayashi; Tsuneo Saga; N Tsuboyama; T Nakamura; Junji Konishi
Technetium-99m (V)-dimercaptosuccinic acid: normal accumulation in the breasts.
European journal of nuclear medicine 1997;24(9):1146-8.
1997: BF Sun; Hisataka Kobayashi; Nhat Le; Tae M Yoo; D Drumm; Chang H Paik; J G McAfee; Jorge Carrasquillo
Biodistribution of 125I-labeled des(1-3) insulin-like growth factor I in tumor-bearing nude mice and its in vitro catabolism.
Cancer research 1997;57(13):2754-9.
1997: Hisataka Kobayashi; Tae M Yoo; D Drumm; Meyoung-Kon Kim; BF Sun; Nhat Le; KO Webber; Ira Pastan; Thomas Waldmann; Chang H Paik; Jorge Carrasquillo
Improved biodistribution of 125I-labeled anti-Tac disulfide-stabilized Fv fragment by blocking its binding to the alpha subunit of the interleukin 2 receptor in the circulation with preinjected humanized anti-Tac IgG.
Cancer research 1997;57(10):1955-61.
1997: M Hosono; Hisataka Kobayashi; Ryota Fujimoto; Y Kotoura; Tadao Tsuboyama; Yoshitaka Matsusue; Tetsuya Nakamura; T Itoh; Junji Konishi
Septum-like structures in lipoma and liposarcoma: MR imaging and pathologic correlation.
Skeletal radiology 1997;26(3):150-4.
1997: Hisataka Kobayashi; Y Kotoura; M Hosono; Tadao Tsuboyama; Harumi Sakahara; Keigo Endo; Junji Konishi
MRI and scintigraphic features of extraabdominal desmoid tumors.
Clinical imaging 1997;21(1):35-9.
1996: Hisataka Kobayashi; Tae M Yoo; IS Kim; Meyoung-Kon Kim; Nhat Le; KO Webber; Ira Pastan; Chang H Paik; William Eckelman; Jorge Carrasquillo
L-lysine effectively blocks renal uptake of 125I- or 99mTc-labeled anti-Tac disulfide-stabilized Fv fragment.
Cancer research 1996;56(16):3788-95.
1996: Harumi Sakahara; M Hosono; Hisataka Kobayashi; Z Yao; Tsuneo Saga; S Yano; Keigo Endo; T Mori; Junji Konishi
Effect of circulating antigen on immunoscintigraphy of ovarian cancer patients using anti-CA125 monoclonal antibody.
Japanese journal of cancer research : Gann 1996;87(6):655-61.
1996: Hisataka Kobayashi; Y Kotoura; M Hosono; Tadao Tsuboyama; H Sakahara; Junji Konishi
Periosteal ganglion of the tibia.
Skeletal radiology 1996;25(4):381-3.
1996: Hisataka Kobayashi; Harumi Sakahara; Keigo Endo; Z S Yao; Junji Konishi
Inflammation-seeking scintigraphy with radiolabeled biotinylated polyclonal IgG followed by the injection of avidin chase.
Nuclear medicine and biology 1996;23(1):29-32.
1996: Hisataka Kobayashi; T Itoh; Y Sasaki; Junji Konishi
Diagnostic imaging of idiopathic adult respiratory distress syndrome (ARDS)/diffuse alveolar damage (DAD) histopathological correlation with radiological imaging.
Clinical imaging 1996;20(1):1-7.
1995: Hisataka Kobayashi; M Hosono; Ryota Fujimoto; Junji Konishi
Tumoral calcinosis-like metastatic calcification in a patient with renal osteodystrophy: CT and scintigraphic appearances.
Clinical nuclear medicine 1995;20(12):1112-4.
1995: M Hosono; Akifumi Takaori-Kondo; Z S Yao; Hisataka Kobayashi; M N Hosono; Harumi Sakahara; Kazunori Imada; M Okuma; Takashi Uchiyama; Junji Konishi
Radioimmunodetection of human leukemia with anti-interleukin-2 receptor antibody in severe combined immunodeficiency mice.
Nuclear medicine and biology 1995;22(7):869-74.
1995: Hisataka Kobayashi; Y Kotoura; M Hosono; Ryota Fujimoto; Tadao Tsuboyama; H Itoh; Junji Konishi
3D-spiral CT of multiple exostoses.
Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society 1995;19(5):419-22.
1995: Harumi Sakahara; H Onodera; M Shirato; Z Yao; Gakuji Ohshio; Hisataka Kobayashi; M Hosono; S Yano; Hiroshi Nakada; Masayuki Imamura
Immunoscintigraphy of colorectal cancer using 111In-labeled monoclonal antibody to mucin.
Cancer immunology, immunotherapy : CII 1995;41(3):157-61.
1995: Hisataka Kobayashi; Harumi Sakahara; Keigo Endo; Z S Yao; S Toyama; Junji Konishi
Repeating the avidin "chase" markedly improved the biodistribution of radiolabelled biotinylated antibodies and promoted the excretion of additional background radioactivity.
European journal of cancer (Oxford, England : 1990) 1995;31A(10):1689-96.
1995: Hisataka Kobayashi; Y Kotoura; M Hosono; Tadao Tsuboyama; N Nishijima; Harumi Sakahara; Junji Konishi
Uptake of pentavalent technetium-99m dimercaptosuccinic acid in idiopathic synovial chondromatosis.
Annals of nuclear medicine 1995;9(3):153-5.
1995: Hisataka Kobayashi; Y Kotoura; Tadao Tsuboyama; M Hosono; Harumi Sakahara; Junji Konishi
Incidental detection of papillary carcinoma of the thyroid by Tc-99m (V) DMSA tumor scintigraphy.
Clinical nuclear medicine 1995;20(7):638.
1995: Hisataka Kobayashi; K H Suzuki; Harumi Sakahara; Z S Yao; A Yokoyama; Junji Konishi
Oxygen bubbling can improve the labelling of pentavalent technetium-99m dimercaptosuccinic acid.
European journal of nuclear medicine 1995;22(6):559-62.
1995: Z Yao; M Zhang; Hisataka Kobayashi; Harumi Sakahara; Hiroshi Nakada; Ikuo Yamashina; Junji Konishi
Improved targeting of radiolabeled streptavidin in tumors pretargeted with biotinylated monoclonal antibodies through an avidin chase.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1995;36(5):837-41.
1995: Hisataka Kobayashi; Y Kotoura; M Hosono; Harumi Sakahara; M Hosono; Z S Yao; Tadao Tsuboyama; T Yamamuro; Keigo Endo; Junji Konishi
Diagnostic value of Tc-99m (V) DMSA for chondrogenic tumors with positive Tc-99m HMDP uptake on bone scintigraphy.
Clinical nuclear medicine 1995;20(4):361-4.
1995: Hisataka Kobayashi; Y Kotoura; M Hosono; Tadao Tsuboyama; Harumi Sakahara; Junji Konishi
Solitary muscular involvement by tuberculosis: CT, MRI, and scintigraphic features.
Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society 1995;19(2):237-40.
1995: Hisataka Kobayashi; Harumi Sakahara; Keigo Endo; M Hosono; Z S Yao; S Toyama; Junji Konishi
Comparison of the chase effects of avidin, streptavidin, neutravidin, and avidin-ferritin on a radiolabeled biotinylated anti-tumor monoclonal antibody.
Japanese journal of cancer research : Gann 1995;86(3):310-4.
1995: Z Yao; Harumi Sakahara; M Zhang; Hisataka Kobayashi; Hiroshi Nakada; Ikuo Yamashina; Junji Konishi
Radioimmunoimaging of colon cancer xenografts with anti-Tn monoclonal antibody.
Nuclear medicine and biology 1995;22(2):199-203.
1995: M Hosono; N Sone; Keigo Endo; Tsuneo Saga; Hisataka Kobayashi; M N Hosono; Harumi Sakahara; K Yasunaga; Junji Konishi
Kinetics of platelets in dogs with thrombocytopenia induced by antiglycoprotein IIb/IIIa receptor monoclonal antibody.
Nuclear medicine and biology 1995;22(1):71-6.
1994: Harumi Sakahara; H Onodera; Hisataka Kobayashi; Z Yao; Ikuo Yamashina; Junji Konishi
Reduced bone marrow uptake of indium-111 labelled monoclonal antibody after radiotherapy.
European journal of nuclear medicine 1994;21(11):1252-3.
1994: Hisataka Kobayashi; Y Kotoura; M Hosono; Harumi Sakahara; T Yamamuro; Keigo Endo; Junji Konishi
Case report: uptake of pentavalent technetium-99m dimercaptosuccinic acid by pigmented villonodular synovitis: comparison with computed tomography, magnetic resonance imaging and gallium-67 scintigraphy.
The British journal of radiology 1994;67(802):1030-2.
1994: Hisataka Kobayashi; Harumi Sakahara; M Hosono; Z S Yao; S Toyama; Keigo Endo; Junji Konishi
Improved clearance of radiolabeled biotinylated monoclonal antibody following the infusion of avidin as a "chase" without decreased accumulation in the target tumor.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1994;35(10):1677-84.
1994: Hisataka Kobayashi; Chohei Shigeno; Harumi Sakahara; M Hosono; M Hosono; Z S Yao; Keigo Endo; Junji Konishi
Intraosseous hemangiomatosis: technetium-99m(V)dimercaptosuccinic acid and technetium-99m-hydroxymethylene diphosphonate imaging.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1994;35(9):1482-4.
1994: Hisataka Kobayashi; Y Kotoura; Harumi Sakahara; M Hosono; M Hosono; T Tsaboyama; T Yamamuro; Keigo Endo; Junji Konishi
Schwannoma of the extremities: comparison of MRI and pentavalent technetium-99m-dimercaptosuccinic acid and gallium-67-citrate scintigraphy.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1994;35(7):1174-8.
1994: Hisataka Kobayashi; Y Kotoura; H Sakahara; T Yamamuro; K Endo; Junji Konishi
Solitary muscular sarcoidosis: CT, MRI, and scintigraphic characteristics.
Skeletal radiology 1994;23(4):293-5.
1994: Harumi Sakahara; Keigo Endo; Tsuneo Saga; M Hosono; Hisataka Kobayashi; Junji Konishi
131I-metaiodobenzylguanidine therapy for malignant pheochromocytoma.
Annals of nuclear medicine 1994;8(2):133-7.
1994: Hisataka Kobayashi; T Itoh; R Murata; Junji Konishi
Detection of intrarenal venous invasions of malignant renal neoplasms by retrograde renal venography.
Clinical imaging 1994;18(2):115-8.
1994: Harumi Sakahara; T Kousaka; N Hattori; K Tomida; Z Yao; M Hosono; Hisataka Kobayashi; M Shirato; Keigo Endo; Junji Konishi
Dissociation in serum CA125 concentrations measured by different monoclonal antibodies.
Gynecologic oncology 1994;52(3):301-5.
1994: M Hosono; Keigo Endo; M N Hosono; Hisataka Kobayashi; M Shirato; Harumi Sakahara; R Ueda; Junji Konishi
Treatment of small-cell lung cancer xenografts with iodine-131-anti-neural cell adhesion molecule monoclonal antibody and evaluation of absorbed dose in tissue.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1994;35(2):296-300.
1994: Hisataka Kobayashi; Harumi Sakahara; M Hosono; M Shirato; Junji Konishi
Pentavalent technetium-99m dimercaptosuccinic acid SPECT of metastatic renal cell carcinoma in the scalp and in the brain.
Clinical nuclear medicine 1994;19(2):136-7.
1994: Hisataka Kobayashi; Harumi Sakahara; M Hosono; M Shirato; Keigo Endo; Y Kotoura; T Yamamuro; Junji Konishi
Soft-tissue tumors: diagnosis with Tc-99m (V) dimercaptosuccinic acid scintigraphy.
Radiology 1994;190(1):277-80.
1994: Hisataka Kobayashi; Harumi Sakahara; M Hosono; M Shirato; S Kondo; S Miyatake; H Kikuchi; Y Namba; K Endo; Junji Konishi
Scintigraphic detection of neural-cell-derived small-cell lung cancer using glioma-specific antibody.
Journal of cancer research and clinical oncology 1994;120(5):259-62.
1993: Harumi Sakahara; T Kousaka; N Hattori; M Hosono; Hisataka Kobayashi; M Shirato; Z Yao; Junji Konishi
[Evaluation of a cytokeratin 19 assay kit "BALL ELSA CYFRA21-1"].
Kaku igaku. The Japanese journal of nuclear medicine 1993;30(12):1475-9.
1993: Harumi Sakahara; Tsuneo Saga; Keigo Endo; T Kousaka; M Hosono; Hisataka Kobayashi; M Shirato; Junji Konishi
Similarity and co-expression of tumour-associated antigens recognised by different monoclonal antibodies.
British journal of cancer 1993;68(5):920-5.
1993: Hisataka Kobayashi; Harumi Sakahara; M Hosono; M Shirato; Junji Konishi; Y Kotoura; T Yamamuro; Keigo Endo
Scintigraphic evaluation of tenosynovial giant-cell tumor using technetium-99m(V)-dimercaptosuccinic acid.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1993;34(10):1745-7.
1993: Hisataka Kobayashi; Harumi Sakahara; M Hosono; M Shirato; Junji Konishi; Jun A Takahashi; Y Oda; H Kikuchi; Keigo Endo; Y Kozai
Scintigraphic detection of xenografted tumors producing human basic fibroblast growth factor.
Cancer immunology, immunotherapy : CII 1993;37(5):281-5.
1993: T Nakai; Harumi Sakahara; Keigo Endo; M Shirato; Hisataka Kobayashi; M Hosono; Tsuneo Saga; M Sakamoto; Junji Konishi
Changes in CA125 release and surface expression caused by drugs in uterine cervix adenocarcinoma cells.
Annals of nuclear medicine 1993;7(3):133-9.
1993: Hisataka Kobayashi; Harumi Sakahara; Tsuneo Saga; M Hosono; M Shirato; H Kanda; K Ishibashi; T Watanabe; Keigo Endo; I Ishiwata
A human/mouse chimeric monoclonal antibody against CA125 for radioimmunoimaging of ovarian cancer.
Cancer immunology, immunotherapy : CII 1993;37(3):143-9.
1993: Harumi Sakahara; Tsuneo Saga; Keigo Endo; N Hattori; M Hosono; Hisataka Kobayashi; M Shirato; T Yamamuro; S Toyama; Yasushi Arano
In vivo instability of reduction-mediated 99mTc-labeled monoclonal antibody.
Nuclear medicine and biology 1993;20(5):617-23.
1993: Yoriko Kajiya; Hisataka Kobayashi; Masayuki Nakajo
Transarterial internal radiation therapy with I-131 Lipiodol for multifocal hepatocellular carcinoma: immediate and long-term results.
Cardiovascular and interventional radiology 1993;16(3):150-7.
1993: Hisataka Kobayashi; Harumi Sakahara; T Itoh; T Kudoh; T Takagi; K Shibuya; S Nomura; M Hosono; Keigo Endo; Junji Konishi
Technetium-99m(V)dimercaptosuccinic acid uptake in intra-abdominal massive deposit of amyloid protein.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1993;34(5):815-7.
1993: M Hosono; Tsuneo Saga; Harumi Sakahara; Hisataka Kobayashi; M Shirato; Keigo Endo; T Yamamoto; T Akiyama; K Toyoshima; Junji Konishi
Construction of immunoradiometric assay for circulating c-erbB-2 protooncogene product in advanced breast cancer patients.
Japanese journal of cancer research : Gann 1993;84(2):147-52.
1992: Hiroki Inoue; A Hori; M Satake; I Kanetsuki; K Ueno; H Nishida; K Ikeda; Hisataka Kobayashi; Masayuki Nakajo
[Liver abscess formation after treatment of liver cancer by arterial injection using adriamycin/mitomycin C oil suspension (ADMOS)].
Nihon Igaku Hōshasen Gakkai zasshi. Nippon acta radiologica 1992;52(2):155-63.
1992: K Ikeda; Hiroki Inoue; T Yano; Hisataka Kobayashi; Masayuki Nakajo
Comparison of the anticancer effect of ADMOS alone and ADMOS with CDDP in the treatment of hepatocellular carcinoma by intra-arterial injection.
Cancer chemotherapy and pharmacology 1992;31 Suppl():S65-8.
1991: N Miyaji; T Oyama; N Uchiyama; Hisataka Kobayashi; Y Ito; I Akazaki; S Shinohara; S Tanohata
[Results of radiotherapy combined with BAI (bronchial artery infusion) for non-small cell lung cancer--analysis of 104 cases].
Nihon Igaku Hōshasen Gakkai zasshi. Nippon acta radiologica 1991;51(3):270-81.
1990: T Takeshita; N Miyaji; Hisataka Kobayashi; Hiroki Inoue; T Yano; M Asato; Y Ito; S Shinohara
[A case of a rare anomaly of the abdominal aorta--magnetic resonance image and angiographic finding].
Nihon Igaku Hōshasen Gakkai zasshi. Nippon acta radiologica 1990;50(3):258-61.
1990: K Ikeda; Hisataka Kobayashi; S Shinohara; Kouichi Ohkubo
[An experimental trial for quantitative estimation of lipiodol using CT value--application to hepatic arterial infusion therapy].
Nihon Igaku Hōshasen Gakkai zasshi. Nippon acta radiologica 1990;50(1):84-6.
1989: Hiroki Inoue; Hisataka Kobayashi; Y Itoh; S Shinohara
Treatment of liver metastases by arterial injection of adriamycin/mitomycin C lipiodol suspension.
Acta radiologica (Stockholm, Sweden : 1987) 1989;30(6):603-8.
1988: Yoshiyuki Hiraki; Hisataka Kobayashi; Y Itoh; T Yano; K Ikeda; T Sonoda; S Shinohara
[Accumulating patterns of lipiodol and therapeutic effect of combination therapy with ADMOS and CDDP two-route infusion in hepatocellular carcinoma].
Gan to kagaku ryoho. Cancer & chemotherapy 1988;15(8 Pt 2):2525-30.
1988: Masayuki Nakajo; Hisataka Kobayashi; K Shimabukuro; K Shirono; H Sakata; M Taguchi; N Uchiyama; T Sonoda; S Shinohara
Biodistribution and in vivo kinetics of iodine-131 lipiodol infused via the hepatic artery of patients with hepatic cancer.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1988;29(6):1066-77.
1988: S Onohara; Hisataka Kobayashi; Y Itoh; S Shinohara
Intra-arterial cis-platinum infusion with sodium thiosulfate protection and angiotensin II induced hypertension for treatment of hepatocellular carcinoma.
Acta radiologica (Stockholm, Sweden : 1987) 1988;29(2):197-202.
1988: N Uchiyama; Hisataka Kobayashi; Masayuki Nakajo; S Shinohara
Treatment of lung cancer with bronchial artery infusion of cisplatin and intravenous sodium thiosulfate rescue.
Acta oncologica (Stockholm, Sweden) 1988;27(1):57-61.
1987: Hisataka Kobayashi; Hiroki Inoue; J Shimada; T Yano; T Maeda; T Oyama; S Shinohara
Intra-arterial injection of adriamycin/mitomycin C lipiodol suspension in liver metastases.
Acta radiologica (Stockholm, Sweden : 1987) 1987;28(3):275-80.
1984: Hisataka Kobayashi; Masayuki Nakajo; K Shimabukuro; K Shirono; H Sakata; T Oyama; T Sonoda; S Shinohara
[Possibility of radiotherapy of hepatic cancer by transcatheter arterial embolization with radioactive Lipiodol].
Nihon Igaku Hōshasen Gakkai zasshi. Nippon acta radiologica 1984;44(1):96-8.

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