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Hiroshi Kobayashi

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Naoto Furukawa; Seiji Kanayama; Ryuji Kawaguchi; Yoshikazu Sasaki; Aiko Shigemitsu; Juria Akasaka; Hiroshi Kobayashi
CA-125 cut-off value as a predictor for complete interval debulking surgery after neoadjuvant chemotherapy in patients with advanced ovarian cancer.
Natsuki Koike; Aiko Shigemitsu; Taihei Tsunemi; Chiharu Uekuri; Juria Akasaka; Fuminori Ito; Hiroshi Kobayashi
Pathogenesis and malignant transformation of adenomyosis (review).
Hiroshi Shigetomi; Yumi Higashiura; Hirotaka Kajihara; Hiroshi Kobayashi
A potential link of oxidative stress and cell cycle regulation for development of endometriosis.

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2013: Naoto Furukawa; Seiji Kanayama; Ryuji Kawaguchi; Yoshikazu Sasaki; Aiko Shigemitsu; Juria Akasaka; Hiroshi Kobayashi
CA-125 cut-off value as a predictor for complete interval debulking surgery after neoadjuvant chemotherapy in patients with advanced ovarian cancer.
Journal of gynecologic oncology 2013;24(2):141-5.
2013: Natsuki Koike; Aiko Shigemitsu; Taihei Tsunemi; Chiharu Uekuri; Juria Akasaka; Fuminori Ito; Hiroshi Kobayashi
Pathogenesis and malignant transformation of adenomyosis (review).
Oncology reports 2013;29(3):861-7.
2012: Hiroshi Shigetomi; Yumi Higashiura; Hirotaka Kajihara; Hiroshi Kobayashi
A potential link of oxidative stress and cell cycle regulation for development of endometriosis.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2012;28(11):897-902.
2012: Hiroshi Shigetomi; Yumi Higashiura; Hirotaka Kajihara; Hiroshi Kobayashi
Targeted molecular therapies for ovarian cancer: an update and future perspectives (Review).
Oncology reports 2012;28(2):395-408.
2012: Hirotaka Kajihara; Hiroshi Shigetomi; Yoshihiko Yamada; Yumi Higashiura; Hiroshi Kobayashi
The dichotomy in the histogenesis of endometriosis-associated ovarian cancer: clear cell-type versus endometrioid-type adenocarcinoma.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2012;31(4):304-12.
2012: Hiroshi Shigetomi; Yasuhito Tanase; Taihei Tsunemi; Shozo Yoshida; Yoriko Yoshizawa; Naoto Furukawa; Shoji Haruta; Hirotaka Kajihara; Toshiyuki Sado; Hiroshi Kobayashi
Molecular mechanisms linking endometriosis under oxidative stress with ovarian tumorigenesis and therapeutic modalities.
Cancer investigation 2012;30(6):473-80.
2012: Hiroshi Kobayashi
[Ovarian cancer screening].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 4():537-42.
2012: Hiroshi Kobayashi
[Malignant transformation of endometriosis].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 4():493-7.
2012: Ryuji Kawaguchi; Naoto Furukawa; Hiroshi Kobayashi
Cut-off value of D-dimer for prediction of deep venous thrombosis before treatment in ovarian cancer.
Journal of gynecologic oncology 2012;23(2):98-102.
2012: Katsuhiko Naruse; Taketoshi Noguchi; Hidekazu Oi; Toshiyuki Sado; Taihei Tsunemi; Shozo Yoshida; Juria Akasaka; Natsuki Koike; Hiroshi Kobayashi
Peripheral RAGE (receptor for advanced glycation endproducts)-ligands in normal pregnancy and preeclampsia: novel markers of inflammatory response.
Journal of reproductive immunology 2012;93(2):69-74.
2012: Seiji Kanayama; Ryuji Kawaguchi; Naoto Furukawa; Shoji Haruta; Akira Nagai; Hidekazu Oi; Yasuhito Tanase; Yoshihiko Yamada; Shozo Yoshida; Hiroshi Kobayashi
A case of early-stage ovarian carcinoid tumor metastasized to the liver.
Case reports in obstetrics and gynecology 2012;2012():961087.
2012: Hiroshi Kobayashi
The entry of fetal and amniotic fluid components into the uterine vessel circulation leads to sterile inflammatory processes during parturition.
Frontiers in immunology 2012;3():321.
2012: Akira Nagai; Katsuhiko Naruse; Taketoshi Noguchi; Toshiyuki Sado; Yasuhito Tanase; Taihei Tsunemi; Shozo Yoshida; Shoji Haruta; Hiroshi Kobayashi
Antiangiogenic-induced hypertension: the molecular basis of signaling network.
Gynecologic and obstetric investigation 2012;73(2):89-98.
2011: Shoji Haruta; Ryuji Kawaguchi; Naoto Furukawa; Akira Nagai; Yasuhito Tanase; Taihei Tsunemi; Shozo Yoshida; Yoriko Yoshizawa; Hiroshi Kobayashi
Molecular genetics and epidemiology of epithelial ovarian cancer (Review).
Oncology reports 2011;26(6):1347-56.
2011: Naoto Furukawa; Hirotaka Kajihara; Ryuji Kawaguchi; Hiroshi Kobayashi
Evaluation of the vessels of the cardinal ligament by transrectal ultrasonography with color Doppler imaging.
Journal of clinical ultrasound : JCU 2011;39(9):502-5.
2011: Yoshihiko Yamada; Shozo Yoshida; Naoto Furukawa; Shoji Haruta; Ryuji Kawaguchi; Akira Nagai; Hidekazu Oi; Akira Onogi; Hiroshi Shigetomi; Yasuhito Tanase; Taihei Tsunemi; Hiroshi Kobayashi
Redox-active iron-induced oxidative stress in the pathogenesis of clear cell carcinoma of the ovary.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2011;21(7):1200-7.
2011: Yoriko Yoshizawa; Naoto Furukawa; Seiji Kanayama; Ryuji Kawaguchi; Akira Nagai; Hidekazu Oi; Hiroshi Shigetomi; Yoshihiko Yamada; Shozo Yoshida; Hiroshi Kobayashi
Signaling pathway involved in cyclooxygenase-2 up-regulation by hepatocyte growth factor in endometrial cancer cells.
Oncology reports 2011;26(4):957-64.
2011: Ryuji Kawaguchi; Naoto Furukawa; Shoji Haruta; Akira Nagai; Hidekazu Ooi; Aiko Shigemitsu; Yasuhito Tanase; Yoshihiko Yamada; Shozo Yoshida; Hiroshi Kobayashi
[A case of recurrent endometrial cancer metastasis successfully treated with zoledronic Acid].
Gan to kagaku ryoho. Cancer & chemotherapy 2011;38(6):1035-8.
2011: Toshiyuki Sado; Katsuhiko Naruse; Taketoshi Noguchi; Shoji Haruta; Shozo Yoshida; Yasuhito Tanase; Takashi Kitanaka; Hidekazu Oi; Hiroshi Kobayashi
Inflammatory pattern recognition receptors and their ligands: factors contributing to the pathogenesis of preeclampsia.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2011;60(6):509-20.
2011: Yoshihiko Yamada; Hiroshi Shigetomi; Akira Onogi; Shoji Haruta; Ryuji Kawaguchi; Shozo Yoshida; Naoto Furukawa; Akira Nagai; Yasuhito Tanase; Taihei Tsunemi; Hidekazu Oi; Hiroshi Kobayashi
New insights into pattern recognition receptors and their ligands in gynecologic pathologies.
Human immunology 2011;72(3):213-8.
2011: Hirotaka Kajihara; Yoshihiko Yamada; Seiji Kanayama; Naoto Furukawa; Taketoshi Noguchi; Shoji Haruta; Shozo Yoshida; Toshiyuki Sado; Hidekazu Oi; Hiroshi Kobayashi
New insights into the pathophysiology of endometriosis: from chronic inflammation to danger signal.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2011;27(2):73-9.
2011: Ryuji Kawaguchi; Hidekazu Ooi; Yoshihiko Yamada; Naoto Furukawa; Hiroshi Kobayashi
Carcinosarcoma of the uterine corpus with alpha-fetoprotein-producing hepatoid adenocarcinoma: a report of two cases.
Case reports in oncology 2011;4(2):358-62.
2011: Hiroshi Kobayashi; Hirotaka Kajihara; Yoshihiko Yamada; Yasuhito Tanase; Seiji Kanayama; Naoto Furukawa; Taketoshi Noguchi; Shoji Haruta; Shozo Yoshida; Katsuhiko Naruse; Toshiyuki Sado; Hidekazu Oi
Risk of carcinoma in women with ovarian endometrioma.
Frontiers in bioscience (Elite edition) 2011;3():529-39.
2011: Toshiyuki Sado; Takashi Kitanaka; Katsuhiko Naruse; Hidekazu Oi; Taketoshi Noguchi; Shozo Yoshida; Hirotaka Kajihara; Hiroshi Shigetomi; Akira Oonogi; Hiroshi Kobayashi
Anticytokine therapy in preterm labor: current knowledge and future perspectives.
Gynecologic and obstetric investigation 2011;71(1):1-10.
2010: Naoto Furukawa; Hidekazu Oi; Shozo Yoshida; Hiroshi Shigetomi; Seiji Kanayama; Hiroshi Kobayashi
The usefulness of photodynamic eye for sentinel lymph node identification in patients with cervical cancer.
Tumori 2010;96(6):936-40.
2010: Aiko Shigemitsu; Naoto Furukawa; Natsuki Koike; Hiroshi Kobayashi
Endometrial cancer diagnosed by the presence of bone metastasis and treated with zoledronic Acid: a case report and review of the literature.
Case reports in oncology 2010;3(3):471-6.
2010: Hiroshi Shigetomi; Akira Onogi; Hirotaka Kajiwara; Shozo Yoshida; Naoto Furukawa; Shoji Haruta; Yasuhito Tanase; Seiji Kanayama; Taketoshi Noguchi; Yoshihiko Yamada; Hidekazu Oi; Hiroshi Kobayashi
Anti-inflammatory actions of serine protease inhibitors containing the Kunitz domain.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2010;59(9):679-87.
2010: Hirotaka Kajihara; Yoshihiko Yamada; Seiji Kanayama; Naoto Furukawa; Taketoshi Noguchi; Shoji Haruta; Shozo Yoshida; Toshiyuki Sado; Hidekazu Oi; Hiroshi Kobayashi
Clear cell carcinoma of the ovary: potential pathogenic mechanisms (Review).
Oncology reports 2010;23(5):1193-203.
2010: Chizuko Yaguchi; Hidekazu Oi; Hiroshi Kobayashi; Katsutoshi Miura; Naohiro Kanayama
A case of intravenous leiomyomatosis with high levels of hyaluronan.
The journal of obstetrics and gynaecology research 2010;36(2):454-8.
2010: Taketoshi Noguchi; Toshiyuki Sado; Katsuhiko Naruse; Hiroshi Shigetomi; Akira Onogi; Shoji Haruta; Ryuji Kawaguchi; Akira Nagai; Yasuhito Tanase; Shozo Yoshida; Takashi Kitanaka; Hidekazu Oi; Hiroshi Kobayashi
Evidence for activation of Toll-like receptor and receptor for advanced glycation end products in preterm birth.
Mediators of inflammation 2010;2010():490406.
2010: Hidekazu Oi; Katsuhiko Naruse; Taketoshi Noguchi; Toshiyuki Sado; Satoshi Kimura; Naohiro Kanayama; Toshihiko Terao; Hiroshi Kobayashi
Fatal factors of clinical manifestations and laboratory testing in patients with amniotic fluid embolism.
Gynecologic and obstetric investigation 2010;70(2):138-44.
2009: Shozo Yoshida; Naoto Furukawa; Shoji Haruta; Yasuhito Tanase; Seiji Kanayama; Taketoshi Noguchi; Mariko Sakata; Yoshihiko Yamada; Hidekazu Oi; Hiroshi Kobayashi
Theoretical model of treatment strategies for clear cell carcinoma of the ovary: focus on perspectives.
Cancer treatment reviews 2009;35(7):608-15.
2009: Hiroshi Kobayashi
Ovarian cancer in endometriosis: epidemiology, natural history, and clinical diagnosis.
International journal of clinical oncology 2009;14(5):378-82.
2009: Shozo Yoshida; Naoto Furukawa; Shoji Haruta; Yasuhito Tanase; Seiji Kanayama; Taketoshi Noguchi; Mariko Sakata; Yoshihiko Yamada; Hidekazu Oi; Hiroshi Kobayashi
Expression profiles of genes involved in poor prognosis of epithelial ovarian carcinoma: a review.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2009;19(6):992-7.
2009: Hiroshi Kobayashi; Hirotaka Kajiwara; Seiji Kanayama; Yoshihiko Yamada; Naoto Furukawa; Taketoshi Noguchi; Shoji Haruta; Shozo Yoshida; Mariko Sakata; Toshiyuki Sado; Hidekazu Oi
Molecular pathogenesis of endometriosis-associated clear cell carcinoma of the ovary (review).
Oncology reports 2009;22(2):233-40.
2009: Hiroshi Kobayashi; Yoshihiko Yamada; Seiji Kanayama; Naoto Furukawa; Taketoshi Noguchi; Shoji Haruta; Shozo Yoshida; Mariko Sakata; Toshiyuki Sado; Hidekazu Oi
The role of hepatocyte nuclear factor-1beta in the pathogenesis of clear cell carcinoma of the ovary.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2009;19(3):471-9.
2009: Hiroshi Kobayashi; Yoshihiko Yamada; Seiji Kanayama; Naoto Furukawa; Taketoshi Noguchi; Shoji Haruta; Shozo Yoshida; Mariko Sakata; Toshiyuki Sado; Hidekazu Oi
The role of iron in the pathogenesis of endometriosis.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2009;25(1):39-52.
2008: Ryuji Kawaguchi; Yoriko Tsuji; Shoji Haruta; Seiji Kanayama; Mariko Sakata; Yoshihiko Yamada; Hiroyuki Fujita; Hitomi Saito; Keiji Tsuneto; Hiroshi Kobayashi
Clinicopathologic features of ovarian cancer in patients with ovarian endometrioma.
The journal of obstetrics and gynaecology research 2008;34(5):872-7.
2008: Shozo Yoshida; Akira Onogi; Hiroshi Shigetomi; Yoriko Tsuji; Shoji Haruta; Katsuhiko Naruse; Seiji Kanayama; Taketoshi Noguchi; Mariko Sakata; Naoto Furukawa; Toshiyuki Sado; Yoshihiko Yamada; Takashi Kitanaka; Hidekazu Oi; Hiroshi Kobayashi
Two cases of pregnant women with ovarian endometrioma mimicking a malignant ovarian tumor.
Journal of clinical ultrasound : JCU 2008;36(8):512-6.
2008: Seiji Kanayama; Yoshihiko Yamada; Shoji Haruta; Katsuhiko Naruse; Naoto Furukawa; Ryuji Kawaguchi; Shozo Yoshida; Mariko Sakata; Toshiyuki Sado; Takashi Kitanaka; Hidekazu Oi; Hiroshi Kobayashi
Peritoneal disseminated recurrence and lung metastasis after surgery for stage IA uterine papillary serous carcinoma of the endometrium: a case report.
Archives of gynecology and obstetrics 2008;278(3):277-80.
2008: Hiroshi Kobayashi; Kazuhiro Sumimoto; Takashi Kitanaka; Yoshihiko Yamada; Toshiyuki Sado; Mariko Sakata; Shozo Yoshida; Ryuji Kawaguchi; Seiji Kanayama; Hiroshi Shigetomi; Shoji Haruta; Yoriko Tsuji; Sachiyo Ueda; Toshihiko Terao
Ovarian endometrioma--risks factors of ovarian cancer development.
European journal of obstetrics, gynecology, and reproductive biology 2008;138(2):187-93.
2008: Seiji Kanayama; Yoshihiko Yamada; Akira Onogi; Hiroshi Shigetomi; Sachiyo Ueda; Yoriko Tsuji; Shoji Haruta; Ryuji Kawaguchi; Shozo Yoshida; Mariko Sakata; Toshiyuki Sado; Takashi Kitanaka; Hidekazu Oi; Tatsuo Yagyu; Hiroshi Kobayashi
Molecular structure and function analysis of bikunin on down-regulation of tumor necrosis factor-alpha expression in activated neutrophils.
Cytokine 2008;42(2):191-7.
2008: Hiroshi Kobayashi; Yoshihiko Yamada; Toshiyuki Sado; M Sakata; Shozo Yoshida; Ryuji Kawaguchi; Seiji Kanayama; H Shigetomi; S Haruta; Yoriko Tsuji; S Ueda; Takashi Kitanaka
A randomized study of screening for ovarian cancer: a multicenter study in Japan.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2008;18(3):414-20.
2008: Ryuji Kawaguchi; Sachiyo Ueda; Yoriko Tsuji; Shoji Haruta; Seiji Kanayama; Yoshihiko Yamada; Hidekazu Ooi; Hiroshi Kobayashi
Massive ovarian edema in pregnancy after ovulation induction using clomiphene citrate.
Archives of gynecology and obstetrics 2008;277(4):375-8.
2008: Sachiyo Ueda; Yoshihiko Yamada; Yoriko Tsuji; Ryuji Kawaguchi; Shoji Haruta; Hiroshi Shigetomi; Seiji Kanayama; Shozo Yoshida; Mariko Sakata; Toshiyuki Sado; Koji Kitanaka; Hiroshi Kobayashi
Giant abdominal tumor of the ovary.
The journal of obstetrics and gynaecology research 2008;34(1):108-11.
2008: Seiji Kanayama; Yoshihiko Yamada; Ryuji Kawaguchi; Yoriko Tsuji; Shoji Haruta; Hiroshi Kobayashi
Hepatocyte growth factor induces anoikis resistance by up-regulation of cyclooxygenase-2 expression in uterine endometrial cancer cells.
Oncology reports 2008;19(1):117-22.
2008: Hiroshi Kobayashi; Yoshihiko Yamada; Toshiyuki Sado; Mariko Sakata; Shozo Yoshida; Ryuji Kawaguchi; Seiji Kanayama; Hiroshi Shigetomi; Shoji Haruta; Yoriko Tsuji; Sachiyo Ueda; Takashi Kitanaka; Hidekazu Oi
Prevalence of ovarian cancer among women with a CA125 level of 35 U/ml or less.
Gynecologic and obstetric investigation 2008;65(2):133-8.
2007: Yoriko Tsuji; Ryuji Kawaguchi; Shoji Haruta; Hiroshi Shigetomi; Sachiyo Ueda; Seiji Kanayama; Shozo Yoshida; Mariko Sakata; Toshiyuki Sado; Yoshihiko Yamada; Koji Kitanaka; Hiroshi Kobayashi
Late onset of pulmonary embolism caused by lymphocyst following pelvic lymphadenectomy.
The journal of obstetrics and gynaecology research 2007;33(5):734-8.
2007: Toshiyuki Sado; Hidekazu Oi; Mariko Sakata; Shozo Yoshida; Ryuji Kawaguchi; Seiji Kanayama; Hiroshi Shigetomi; Shoji Haruta; Yoriko Tsuji; Sachiyo Ueda; Takashi Kitanaka; Yoshihiko Yamada; Hiroshi Kobayashi
Aging impairs the protective effect of magnesium supplementation on hypertension in spontaneously hypertensive rats.
Magnesium research : official organ of the International Society for the Development of Research on Magnesium 2007;20(3):196-9.
2007: Seiji Kanayama; Yoshihiko Yamada; Akira Onogi; Hiroshi Shigetomi; Sachiyo Ueda; Yoriko Tsuji; Shoji Haruta; Ryuji Kawaguchi; Shozo Yoshida; Mariko Sakata; Toshiyuki Sado; Takashi Kitanaka; Hidekazu Oi; Tatsuo Yagyu; Hiroshi Kobayashi
Bikunin suppresses expression of pro-inflammatory cytokines induced by lipopolysaccharide in neutrophils.
Journal of endotoxin research 2007;13(6):369-76.
2007: Hiroshi Kobayashi; K Sumimoto; N Moniwa; M Imai; K Takakura; T Kuromaki; E Morioka; K Arisawa; T Terao
Risk of developing ovarian cancer among women with ovarian endometrioma: a cohort study in Shizuoka, Japan.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2007;17(1):37-43.
2006: Hiroshi Kobayashi
Endogenous anti-inflammatory substances, inter-alpha-inhibitor and bikunin.
Biological chemistry 2006;387(12):1545-9.
2006: Tatsuo Yagyu; Y Tsuji; S Haruta; Takashi Kitanaka; Yoshihiko Yamada; R Kawaguchi; S Kanayama; Y Tanase; Noriyuki Kurita; Hiroshi Kobayashi
Activation of mammalian target of rapamycin in postmenopausal ovarian endometriosis.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2006;16(4):1545-51.
2006: Yasuhito Tanase; Ryuji Kawaguchi; Shoji Haruta; Seiji Kanayama; Yoshihiko Yamada; Hiroshi Kobayashi
[Adjuvant chemotherapy of paclitaxel plus carboplatin in uterine corpus cancer--comparison with cisplatin, adriamycin plus cyclophosphamide].
Gan to kagaku ryoho. Cancer & chemotherapy 2006;33(7):945-50.
2006: Tatsuo Yagyu; Hiroshi Kobayashi; Hidenori Matsuzaki; Kiyoshi Wakahara; Toshiharu Kondo; Noriyuki Kurita; Hideo Sekino; Kiyokazu Inagaki
Enhanced spontaneous metastasis in bikunin-deficient mice.
International journal of cancer. Journal international du cancer 2006;118(9):2322-8.
2005: Hiroshi Kobayashi; Ryuji Yoshida; Yasufumi Kanada; Yoichi Fukuda; Tatsuo Yagyu; Kiyokazu Inagaki; Toshiharu Kondo; Noriyuki Kurita; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
Suppression of lipopolysaccharide-induced cytokine production of gingival fibroblasts by a soybean, Kunitz trypsin inhibitor.
Journal of periodontal research 2005;40(6):461-8.
2005: Hiroshi Kobayashi; Tatsuo Yagyu; Toshiharu Kondo; Noriyuki Kurita; Kiyokazu Inagaki; Shoji Haruta; Ryuji Kawaguchi; Takashi Kitanaka; Yoshiharu Sakamoto; Yoshihiko Yamada; Naohiro Kanayama; Toshihiko Terao
Suppression of urokinase receptor expression by thalidomide is associated with inhibition of nuclear factor kappaB activation and subsequently suppressed ovarian cancer dissemination.
Cancer research 2005;65(22):10464-71.
2005: Hiroshi Kobayashi; Ryuji Yoshida; Yasufumi Kanada; Yoichi Fukuda; Tatsuo Yagyu; Kiyokazu Inagaki; Toshiharu Kondo; Noriyuki Kurita; Yoshihiko Yamada; Toshiyuki Sado; Takashi Kitanaka; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
A soybean Kunitz trypsin inhibitor reduces tumor necrosis factor-alpha production in ultraviolet-exposed primary human keratinocytes.
Experimental dermatology 2005;14(10):765-74.
2005: Kiyokazu Inagaki; Hiroshi Kobayashi; Ryuji Yoshida; Yasufumi Kanada; Yoichi Fukuda; Tatsuo Yagyu; Toshiharu Kondo; Noriyuki Kurita; Takashi Kitanaka; Yoshihiko Yamada; Yoshiharu Sakamoto; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
Suppression of urokinase expression and invasion by a soybean Kunitz trypsin inhibitor are mediated through inhibition of Src-dependent signaling pathways.
The Journal of biological chemistry 2005;280(36):31428-37.
2005: Hidenori Matsuzaki; Hiroshi Kobayashi; Tatsuo Yagyu; Kiyoshi Wakahara; Toshiharu Kondo; Noriyuki Kurita; Hideo Sekino; Kiyokazu Inagaki; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
Reduced syndecan-1 expression stimulates heparin-binding growth factor-mediated invasion in ovarian cancer cells in a urokinase-independent mechanism.
Oncology reports 2005;14(2):449-57.
2005: Hiroshi Kobayashi; Ryuji Yoshida; Yasufumi Kanada; Yoichi Fukuda; Tatsuo Yagyu; Kiyokazu Inagaki; Toshiharu Kondo; Noriyuki Kurita; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
Suppressing effects of daily oral supplementation of beta-glucan extracted from Agaricus blazei Murill on spontaneous and peritoneal disseminated metastasis in mouse model.
Journal of cancer research and clinical oncology 2005;131(8):527-38.
2005: Hiroshi Kobayashi; Ryuji Yoshida; Yasufumi Kanada; Yoichi Fukuda; Tatsuo Yagyu; Kiyokazu Inagaki; Toshiharu Kondo; Noriyuki Kurita; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
Dietary supplementation of soybean kunitz trypsin inhibitor reduces lipopolysaccharide-induced lethality in mouse model.
Shock (Augusta, Ga.) 2005;23(5):441-7.
2005: Tatsuo Yagyu; Hiroshi Kobayashi; Hidenori Matsuzaki; Kiyoshi Wakahara; Toshiharu Kondo; Noriyuki Kurita; Hideo Sekino; Kiyokazu Inagaki; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
Thalidomide inhibits tumor necrosis factor-alpha-induced interleukin-8 expression in endometriotic stromal cells, possibly through suppression of nuclear factor-kappaB activation.
The Journal of clinical endocrinology and metabolism 2005;90(5):3017-21.
2005: Kiyoshi Wakahara; Hiroshi Kobayashi; Tatsuo Yagyu; Hidenori Matsuzaki; Toshiharu Kondo; Noriyuki Kurita; Hideo Sekino; Kiyokazu Inagaki; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
Bikunin down-regulates heterodimerization between CD44 and growth factor receptors and subsequently suppresses agonist-mediated signaling.
Journal of cellular biochemistry 2005;94(5):995-1009.
2005: Kiyoshi Wakahara; Hiroshi Kobayashi; Tatsuo Yagyu; Hidenori Matsuzaki; Toshiharu Kondo; Noriyuki Kurita; Hideo Sekino; Kiyokazu Inagaki; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
Bikunin suppresses lipopolysaccharide-induced lethality through down-regulation of tumor necrosis factor- alpha and interleukin-1 beta in macrophages.
The Journal of infectious diseases 2005;191(6):930-8.
2005: Hidenori Matsuzaki; Hiroshi Kobayashi; Tatsuo Yagyu; Kiyoshi Wakahara; Toshiharu Kondo; Noriyuki Kurita; Hideo Sekino; Kiyokazu Inagaki; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
Plasma bikunin as a favorable prognostic factor in ovarian cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(7):1463-72.
2004: Hiroshi Kobayashi; Yoichi Fukuda; Ryuji Yoshida; Yasufumi Kanada; Setsuko Nishiyama; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
Suppressing effects of dietary supplementation of soybean trypsin inhibitor on spontaneous, experimental and peritoneal disseminated metastasis in mouse model.
International journal of cancer. Journal international du cancer 2004;112(3):519-24.
2004: Hidenori Matsuzaki; Hiroshi Kobayashi; Tatsuo Yagyu; Kiyoshi Wakahara; Toshiharu Kondo; Noriyuki Kurita; Hideo Sekino; Kiyokazu Inagaki; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
Bikunin inhibits lipopolysaccharide-induced tumor necrosis factor alpha induction in macrophages.
Clinical and diagnostic laboratory immunology 2004;11(6):1140-7.
2004: Tatsuo Yagyu; Hiroshi Kobayashi; Kiyoshi Wakahara; Hidenori Matsuzaki; Toshiharu Kondo; Noriyuki Kurita; Hideo Sekino; Kiyokazu Inagaki; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
A kunitz-type protease inhibitor bikunin disrupts ligand-induced oligomerization of receptors for transforming growth factor (TGF)-beta and subsequently suppresses TGF-beta signalings.
FEBS letters 2004;576(3):408-16.
2004: Kiyoshi Wakahara; Hiroshi Kobayashi; Tatsuo Yagyu; Hidenori Matsuzaki; Toshiharu Kondo; Noriyuki Kurita; Hideo Sekino; Kiyokazu Inagaki; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
Transforming growth factor-beta1-dependent activation of Smad2/3 and up-regulation of PAI-1 expression is negatively regulated by Src in SKOV-3 human ovarian cancer cells.
Journal of cellular biochemistry 2004;93(3):437-53.
2004: Mika Suzuki; Hiroshi Kobayashi; Yoshiko Tanaka; Naohiro Kanayama; Toshihiko Terao
Reproductive failure in mice lacking inter-alpha-trypsin inhibitor (ITI)--ITI target genes in mouse ovary identified by microarray analysis.
The Journal of endocrinology 2004;183(1):29-38.
2004: Yoshiko Tanaka; Hiroshi Kobayashi; Mitsuaki Suzuki; Naohiro Kanayama; Mika Suzuki; Toshihiko Terao
Upregulation of bikunin in tumor-infiltrating macrophages as a factor of favorable prognosis in ovarian cancer.
Gynecologic oncology 2004;94(3):725-34.
2004: Hiroshi Kobayashi; Tatsuo Yagyu; Kiyokazu Inagaki; Toshiharu Kondo; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
Bikunin plus paclitaxel markedly reduces tumor burden and ascites in mouse model of ovarian cancer.
International journal of cancer. Journal international du cancer 2004;110(1):134-9.
2004: Yoshiko Tanaka; Hiroshi Kobayashi; Mika Suzuki; Yasuyuki Hirashima; Naohiro Kanayama; Toshihiko Terao
Genetic downregulation of pregnancy-associated plasma protein-A (PAPP-A) by bikunin reduces IGF-I-dependent Akt and ERK1/2 activation and subsequently reduces ovarian cancer cell growth, invasion and metastasis.
International journal of cancer. Journal international du cancer 2004;109(3):336-47.
2004: Mika Suzuki; Hiroshi Kobayashi; Naohiro Kanayama; Yasushi Saga; Mitsuaki Suzuki; Chen-Yong Lin; Robert B Dickson; Toshihiko Terao
Inhibition of tumor invasion by genomic down-regulation of matriptase through suppression of activation of receptor-bound pro-urokinase.
The Journal of biological chemistry 2004;279(15):14899-908.
2004: Yoshiko Tanaka; Hiroshi Kobayashi; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
Transforming growth factor-beta1-dependent urokinase up-regulation and promotion of invasion are involved in Src-MAPK-dependent signaling in human ovarian cancer cells.
The Journal of biological chemistry 2004;279(10):8567-76.
2004: Hiroshi Kobayashi; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
Genetic down-regulation of phosphoinositide 3-kinase by bikunin correlates with suppression of invasion and metastasis in human ovarian cancer HRA cells.
The Journal of biological chemistry 2004;279(8):6371-9.
2004: Hiroshi Kobayashi; Tatsuo Yagyu; Kiyokazu Inagaki; Toshiharu Kondo; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
Therapeutic efficacy of once-daily oral administration of a Kunitz-type protease inhibitor, bikunin, in a mouse model and in human cancer.
Cancer 2004;100(4):869-77.
2004: Hiroshi Kobayashi; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
A soybean Kunitz trypsin inhibitor suppresses ovarian cancer cell invasion by blocking urokinase upregulation.
Clinical & experimental metastasis 2004;21(2):159-66.
2003: Yasuyuki Hirashima; Hiroshi Kobayashi; Mika Suzuki; Yoshiko Tanaka; Naohiro Kanayama; Toshihiko Terao
Transforming growth factor-beta1 produced by ovarian cancer cell line HRA stimulates attachment and invasion through an up-regulation of plasminogen activator inhibitor type-1 in human peritoneal mesothelial cells.
The Journal of biological chemistry 2003;278(29):26793-802.
2003: Yoshiko Tanaka; Hiroshi Kobayashi; Mitsuaki Suzuki; Naohiro Kanayama; Mika Suzuki; Toru Yamakawa; Hideaki Morishita; Toshihiko Terao
Reduced bikunin gene expression as a factor of poor prognosis in ovarian carcinoma.
Cancer 2003;98(2):424-30.
2003: Hiroshi Kobayashi; Mika Suzuki; Yasuyuki Hirashima; Toshihiko Terao
The protease inhibitor bikunin, a novel anti-metastatic agent.
Biological chemistry 2003;384(5):749-54.
2003: Mika Suzuki; Hiroshi Kobayashi; Yoshiko Tanaka; Yasuyuki Hirashima; Naohiro Kanayama; Yuji Takei; Yasushi Saga; Mitsuaki Suzuki; Hiroshi Itoh; Toshihiko Terao
Bikunin target genes in ovarian cancer cells identified by microarray analysis.
The Journal of biological chemistry 2003;278(17):14640-6.
2003: Mika Suzuki; Hiroshi Kobayashi; Yoshiko Tanaka; Yasuyuki Hirashima; Naohiro Kanayama; Yuji Takei; Yasushi Saga; Mitsuaki Suzuki; Hiroshi Itoh; Toshihiko Terao
Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cell line by overexpression of bikunin.
International journal of cancer. Journal international du cancer 2003;104(3):289-302.
2003: Hiroshi Kobayashi; Mika Suzuki; Yoshiko Tanaka; Naohiro Kanayama; Toshihiko Terao
A Kunitz-type protease inhibitor, bikunin, inhibits ovarian cancer cell invasion by blocking the calcium-dependent transforming growth factor-beta 1 signaling cascade.
The Journal of biological chemistry 2003;278(10):7790-9.
2003: Guang Wei Sun; Hiroshi Kobayashi; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
Follicle-stimulating hormone and insulin-like growth factor I synergistically induce up-regulation of cartilage link protein (Crtl1) via activation of phosphatidylinositol-dependent kinase/Akt in rat granulosa cells.
Endocrinology 2003;144(3):793-801.
2002: Hiroshi Kobayashi; Mika Suzuki; Naohiro Kanayama; Takashi Nishida; Masaharu Takigawa; Toshihiko Terao
CD44 stimulation by fragmented hyaluronic acid induces upregulation of urokinase-type plasminogen activator and its receptor and subsequently facilitates invasion of human chondrosarcoma cells.
International journal of cancer. Journal international du cancer 2002;102(4):379-89.
2002: Junko Goto; Nobuhiko Suganuma; Kayoko Takata; Kimiya Kitamura; Toshihiko Asahina; Hiroshi Kobayashi; Yoshinori Muranaka; Madoka Furuhashi; Naohiro Kanayama
Morphological analyses of interleukin-8 effects on rat ovarian follicles at ovulation and luteinization in vivo.
Cytokine 2002;20(4):168-73.
2002: Yoshiko Tanaka; Hiroshi Kobayashi; Mitsuaki Suzuki; Naohiro Kanayama; Mika Suzuki; Toshihiko Terao
Thymidine phosphorylase expression in tumor-infiltrating macrophages may be correlated with poor prognosis in uterine endometrial cancer.
Human pathology 2002;33(11):1105-13.
2002: Guang Wei Sun; Hiroshi Kobayashi; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
Production of cartilage link protein by human granulosa-lutein cells.
The Journal of endocrinology 2002;175(2):505-15.
2002: Guang Wei Sun; Hiroshi Kobayashi; Mika Suzuki; Naohiro Kanayama; Toshihiko Terao
Link protein as an enhancer of cumulus cell-oocyte complex expansion.
Molecular reproduction and development 2002;63(2):223-31.
2002: Mika Suzuki; Hiroshi Kobayashi; Naohiro Kanayama; Takashi Nishida; Masaharu Takigawa; Toshihiko Terao
CD44 stimulation by fragmented hyaluronic acid induces upregulation and tyrosine phosphorylation of c-Met receptor protein in human chondrosarcoma cells.
Biochimica et biophysica acta 2002;1591(1-3):37-44.
2002: Hiroshi Kobayashi; Mika Suzuki; Naohiro Kanayama; Takashi Nishida; Masaharu Takigawa; Toshihiko Terao
Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade.
European journal of biochemistry / FEBS 2002;269(16):3945-57.
2002: Mika Suzuki; Hiroshi Kobayashi; Michio Fujie; Takashi Nishida; Masaharu Takigawa; Naohiro Kanayama; Toshihiko Terao
Kunitz-type protease inhibitor bikunin disrupts phorbol ester-induced oligomerization of CD44 variant isoforms containing epitope v9 and subsequently suppresses expression of urokinase-type plasminogen activator in human chondrosarcoma cells.
The Journal of biological chemistry 2002;277(10):8022-32.
2001: Y Hirashima; Hiroshi Kobayashi; Tomizo Nishiguchi; K Miura; Naohiro Kanayama
A case of glassy cell carcinoma of the uterine cervix effectively responding to chemotherapy with paclitaxel and carboplatin.
Anti-cancer drugs 2001;12(7):627-30.
2001: Mika Suzuki; Hiroshi Kobayashi; Shinji Kageyama; K Shibata; Michio Fujie; Toshihiko Terao
Excretion of bikunin and its fragments in the urine of patients with renal stones.
The Journal of urology 2001;166(1):268-74.
2001: Mika Suzuki; Hiroshi Kobayashi; Yoshiko Tanaka; Yasuyuki Hirashima; Toshihiko Terao
Structure and function analysis of urinary trypsin inhibitor (UTI): identification of binding domains and signaling property of UTI by analysis of truncated proteins.
Biochimica et biophysica acta 2001;1547(1):26-36.
2001: Yasuyuki Hirashima; Hiroshi Kobayashi; Mika Suzuki; Yoshiko Tanaka; Naohiro Kanayama; Michio Fujie; Takashi Nishida; Masaharu Takigawa; Toshihiko Terao
Characterization of binding properties of urinary trypsin inhibitor to cell-associated binding sites on human chondrosarcoma cell line HCS-2/8.
The Journal of biological chemistry 2001;276(17):13650-6.
2001: Hiroshi Kobayashi; Mika Suzuki; Yoshiko Tanaka; Yasuyuki Hirashima; Toshihiko Terao
Suppression of urokinase expression and invasiveness by urinary trypsin inhibitor is mediated through inhibition of protein kinase C- and MEK/ERK/c-Jun-dependent signaling pathways.
The Journal of biological chemistry 2001;276(3):2015-22.
2001: Fang Shu; Motoi Sugimura; Hiroshi Kobayashi; Takao Kobayashi; Naohiro Kanayama
Activated protein C prevents development of phosphatidylserine-induced intrauterine growth restriction in mice.
Seminars in thrombosis and hemostasis 2001;27(2):99-105.
2000: Hiroshi Kobayashi; Mika Suzuki; Guang Wei Sun; Yasuyuki Hirashima; Toshihiko Terao
Suppression of urokinase-type plasminogen activator expression from human ovarian cancer cells by urinary trypsin inhibitor.
Biochimica et biophysica acta 2000;1481(2):310-6.
2000: Hiroshi Kobayashi; Yasuyuki Hirashima; Toshihiko Terao
Human myometrial cells in culture express specific binding sites for urinary trypsin inhibitor.
Molecular human reproduction 2000;6(8):735-42.
2000: Hiroshi Kobayashi; Yasuyuki Hirashima; Guang Wei Sun; Michio Fujie; Takashi Nishida; Masaharu Takigawa; Toshihiko Terao
Identity of urinary trypsin inhibitor-binding protein to link protein.
The Journal of biological chemistry 2000;275(28):21185-91.
2000: Hiroshi Kobayashi; Yasuyuki Hirashima; Guang Wei Sun; H Ohi; Michio Fujie; Toshihiko Terao
Identification and characterization of a Kunitz-type protease inhibitor in ascites fluid from patients with ovarian carcinoma.
International journal of cancer. Journal international du cancer 2000;87(1):44-54.
2000: Hiroshi Kobayashi
Invasive capacity of heterotopic endometrium.
Gynecologic and obstetric investigation 2000;50 Suppl 1():26-32.
2000: Fang Shu; Motoi Sugimura; Naohiro Kanayama; Hiroshi Kobayashi; Takao Kobayashi; Toshihiko Terao
Immunohistochemical study of annexin V expression in placentae of preeclampsia.
Gynecologic and obstetric investigation 2000;49(1):17-23.
1999: Guang Wei Sun; Hiroshi Kobayashi; Toshihiko Terao
Expression of link protein during mouse follicular development.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1999;47(11):1433-42.
1999: Hiroshi Kobayashi; Guang Wei Sun; Yasuyuki Hirashima; Toshihiko Terao
Identification of link protein during follicle development and cumulus cell cultures in rats.
Endocrinology 1999;140(8):3835-42.
1999: Hiroshi Kobayashi; Guang Wei Sun; Toshihiko Terao
Urinary trypsin inhibitor down-regulates hyaluronic acid fragment-induced prostanoid release in cultured human amnion cells by inhibiting cyclo-oxygenase-2 expression.
Molecular human reproduction 1999;5(7):662-7.
1999: Hiroshi Kobayashi; Guang Wei Sun; Toshihiko Terao
Immunolocalization of hyaluronic acid and inter-alpha-trypsin inhibitor in mice.
Cell and tissue research 1999;296(3):587-97.
1999: Hiroshi Kobayashi; Guang Wei Sun; Yoshiko Tanaka; T Kondo; Toshihiko Terao
Serum hyaluronic acid levels during pregnancy and labor.
Obstetrics and gynecology 1999;93(4):480-4.
1999: Tomizo Nishiguchi; Takao Kobayashi; Motoi Sugimura; Hiroshi Kobayashi; Toshihiko Terao
Upregulation of thrombomodulin antigen levels in U937 cells by combined stimulation with estradiol-17beta and vitamin K2 (menaquinone 4).
Seminars in thrombosis and hemostasis 1999;25(5):509-17.
1999: Hiroshi Kobayashi; K Suzuki; D Sugino; Toshihiko Terao
Urinary trypsin inhibitor levels in amniotic fluid of normal human pregnancy: decreased levels observed at parturition.
American journal of obstetrics and gynecology 1999;180(1 Pt 1):141-7.
1998: Hiroshi Kobayashi; Guang Wei Sun; Toshihiko Terao
Production of prostanoids via increased cyclo-oxygenase-2 expression in human amnion cells in response to low molecular weight hyaluronic acid fragment.
Biochimica et biophysica acta 1998;1425(2):369-76.
1998: Hiroshi Kobayashi; Y Okada; Toshihiko Asahina; J Gotoh; Toshihiko Terao
The kallikrein-kinin system, but not vascular endothelial growth factor, plays a role in the increased vascular permeability associated with ovarian hyperstimulation syndrome.
Journal of molecular endocrinology 1998;20(3):363-74.
1998: Hiroshi Kobayashi; K Shibata; Michio Fujie; D Sugino; Toshihiko Terao
Identification of structural domains in inter-alpha-trypsin involved in calcium oxalate crystallization.
Kidney international 1998;53(6):1727-35.
1998: Hiroshi Kobayashi; Yasuyuki Hirashima; Guang Wei Sun; Michio Fujie; S Shibata; S Tamotsu; K Kato; H Morishita; Toshihiko Terao
Internalization of urinary trypsin inhibitor in human uterine fibroblasts.
Pflügers Archiv : European journal of physiology 1998;436(1):16-25.
1998: Hiroshi Kobayashi; D Sugino; M Y She; H Ohi; Yasuyuki Hirashima; H Shinohara; Michio Fujie; K Shibata; Toshihiko Terao
A bifunctional hybrid molecule of the amino-terminal fragment of urokinase and domain II of bikunin efficiently inhibits tumor cell invasion and metastasis.
European journal of biochemistry / FEBS 1998;253(3):817-26.
1998: Hiroshi Kobayashi; Yasuyuki Hirashima; Guang Wei Sun; Michio Fujie; K Shibata; S Tamotsu; K Miura; D Sugino; Yoshiko Tanaka; S Kondo; Toshihiko Terao
Identification and characterization of the cell-associated binding protein for urinary trypsin inhibitor.
Biochimica et biophysica acta 1998;1383(2):253-68.
1998: H Oi; Hiroshi Kobayashi; Y Hirashima; T Yamazaki; Takao Kobayashi; Toshihiko Terao
Serological and immunohistochemical diagnosis of amniotic fluid embolism.
Seminars in thrombosis and hemostasis 1998;24(5):479-84.
1998: Motoi Sugimura; F Su; Naohiro Kanayama; Hiroshi Kobayashi; Takao Kobayashi; Toshihiko Terao
Anticoagulant activity in non-immunoglobulin fraction from plasma of patients with antiphospholipid syndrome.
Seminars in thrombosis and hemostasis 1998;24(5):473-7.
1998: Hiroshi Kobayashi; D Sugino; Toshihiko Terao
Urinary trypsin inhibitor, a Kunitz-type protease inhibitor, modulates tumor necrosis factor-stimulated activation and translocation of protein kinase C in U937 cells.
International journal of oncology 1998;12(1):95-105.
1997: Hiroshi Kobayashi; Toshihiko Terao
Hyaluronic acid-specific regulation of cytokines by human uterine fibroblasts.
The American journal of physiology 1997;273(4 Pt 1):C1151-9.
1997: E El Maradny; Naohiro Kanayama; Hiroshi Kobayashi; B Hossain; S Khatun; S Liping; Takao Kobayashi; Toshihiko Terao
The role of hyaluronic acid as a mediator and regulator of cervical ripening.
Human reproduction (Oxford, England) 1997;12(5):1080-8.
1997: Yasuyuki Hirashima; Hiroshi Kobayashi; J Gotoh; Toshihiko Terao
Inter-alpha-trypsin inhibitor is concentrated in the pericellular environment of mouse granulosa cells through hyaluronan-binding.
European journal of obstetrics, gynecology, and reproductive biology 1997;73(1):79-84.
1997: Hiroshi Kobayashi; H Ooi; H Hayakawa; T Arai; Y Matsuda; K Gotoh; T Tarao
Histological diagnosis of amniotic fluid embolism by monoclonal antibody TKH-2 that recognizes NeuAc alpha 2-6GalNAc epitope.
Human pathology 1997;28(4):428-33.
1996: Hiroshi Kobayashi; J Gotoh; Toshihiko Terao
Urinary trypsin inhibitor efficiently inhibits urokinase production in tumor necrosis factor-stimulated cells.
European journal of cell biology 1996;71(4):380-6.
1996: Hiroshi Kobayashi
[Mechanism of tumor cell-induced extracellular matrix degradation--inhibition of cell-surface proteolytic activity might have a therapeutic effect on tumor cell invasion and metastasis].
Nihon Sanka Fujinka Gakkai zasshi 1996;48(8):623-32.
1996: Hiroshi Kobayashi; J Gotoh; Yasuyuki Hirashima; Toshihiko Terao
Inter-alpha-trypsin inhibitor bound to tumor cells is cleaved into the heavy chains and the light chain on the cell surface.
The Journal of biological chemistry 1996;271(19):11362-7.
1995: Hiroshi Kobayashi; H Shinohara; Michio Fujie; J Gotoh; M Itoh; K Takeuchi; Toshihiko Terao
Inhibition of metastasis of Lewis lung carcinoma by urinary trypsin inhibitor in experimental and spontaneous metastasis models.
International journal of cancer. Journal international du cancer 1995;63(3):455-62.
1995: Hiroshi Kobayashi; H Shinohara; J Gotoh; Michio Fujie; S Fujishiro; Toshihiko Terao
Anti-metastatic therapy by urinary trypsin inhibitor in combination with an anti-cancer agent.
British journal of cancer 1995;72(5):1131-7.
1995: Hiroshi Kobayashi; J Gotoh; Naohiro Kanayama; Yasuyuki Hirashima; Toshihiko Terao; D Sugino
Inhibition of tumor cell invasion through matrigel by a peptide derived from the domain II region in urinary trypsin inhibition.
Cancer research 1995;55(9):1847-52.
1995: Hiroshi Kobayashi; J Gotoh; Yasuyuki Hirashima; Michio Fujie; D Sugino; Toshihiko Terao
Inhibitory effect of a conjugate between human urokinase and urinary trypsin inhibitor on tumor cell invasion in vitro.
The Journal of biological chemistry 1995;270(14):8361-6.
1994: Hiroshi Kobayashi; S Fujishiro; Toshihiko Terao
Impact of urokinase-type plasminogen activator and its inhibitor type 1 on prognosis in cervical cancer of the uterus.
Cancer research 1994;54(24):6539-48.
1994: Hiroshi Kobayashi; J Gotoh; Michio Fujie; Toshihiko Terao
Characterization of the cellular binding site for the urinary trypsin inhibitor.
The Journal of biological chemistry 1994;269(32):20642-7.
1994: Hiroshi Kobayashi; J Gotoh; Michio Fujie; H Shinohara; N Moniwa; Toshihiko Terao
Inhibition of metastasis of Lewis lung carcinoma by a synthetic peptide within growth factor-like domain of urokinase in the experimental and spontaneous metastasis model.
International journal of cancer. Journal international du cancer 1994;57(5):727-33.
1994: Hiroshi Kobayashi; Michio Fujie; H Shinohara; H Ohi; M Sugimura; Toshihiko Terao
Effects of urinary trypsin inhibitor on the invasion of reconstituted basement membranes by ovarian cancer cells.
International journal of cancer. Journal international du cancer 1994;57(3):378-84.
1994: Hiroshi Kobayashi; J Gotoh; H Shinohara; N Moniwa; Toshihiko Terao
Inhibition of the metastasis of Lewis lung carcinoma by antibody against urokinase-type plasminogen activator in the experimental and spontaneous metastasis model.
Thrombosis and haemostasis 1994;71(4):474-80.
1994: Hiroshi Kobayashi; H Shinohara; H Ohi; M Sugimura; Toshihiko Terao; Michio Fujie
Urinary trypsin inhibitor (UTI) and fragments derived from UTI by limited proteolysis efficiently inhibit tumor cell invasion.
Clinical & experimental metastasis 1994;12(2):117-28.
1994: M Sugimura; Hiroshi Kobayashi; Toshihiko Terao
Plasmin modulators, aprotinin and anti-catalytic plasmin antibody, efficiently inhibit destruction of bovine vascular endothelial cells by choriocarcinoma cells.
Gynecologic oncology 1994;52(3):337-46.
1994: Hiroshi Kobayashi; H Shinohara; K Takeuchi; M Itoh; Michio Fujie; M Saitoh; Toshihiko Terao
Inhibition of the soluble and the tumor cell receptor-bound plasmin by urinary trypsin inhibitor and subsequent effects on tumor cell invasion and metastasis.
Cancer research 1994;54(3):844-9.
1994: S Fujishiro; Hiroshi Kobayashi; Toshihiko Terao
[Urokinase-type plasminogen activator as a predictor for lymph nodes metastasis of uterine cervical cancer].
Nihon Sanka Fujinka Gakkai zasshi 1994;46(2):129-36.
1994: Hiroshi Kobayashi; N Moniwa; J Gotoh; M Sugimura; Toshihiko Terao
Role of activated protein C in facilitating basement membrane invasion by tumor cells.
Cancer research 1994;54(1):261-7.
1994: Hiroshi Kobayashi; H Ohi; Toshihiko Terao
Analysis of monoclonal antibodies reactive with meconium- and amniotic fluid-derived mucin.
Journal of clinical laboratory analysis 1994;8(1):27-34.
1993: Hiroshi Kobayashi; H Ohi; N Moniwa; H Shinohara; Toshihiko Terao
Characterization of CA 125 antigen identified by monoclonal antibodies that recognize different epitopes.
Clinical biochemistry 1993;26(5):391-7.
1993: Hiroshi Kobayashi; W Ida; Toshihiko Terao; Y Kawashima
Molecular characteristics of the CA 125 antigen produced by human endometrial epithelial cells: comparison between eutopic and heterotopic epithelial cells.
American journal of obstetrics and gynecology 1993;169(3):725-30.
1993: Hiroshi Kobayashi; H Ohi; H Shinohara; Toshihiko Terao
[Heterogeneity of the CA125 antigen that coexpresses sialyl Tn and CA19-9 antigens].
Nihon Sanka Fujinka Gakkai zasshi 1993;45(9):980-6.
1993: Hiroshi Kobayashi; N Moniwa; M Sugimura; H Shinohara; H Ohi; Toshihiko Terao
Effects of membrane-associated cathepsin B on the activation of receptor-bound prourokinase and subsequent invasion of reconstituted basement membranes.
Biochimica et biophysica acta 1993;1178(1):55-62.
1993: M Sugimura; Hiroshi Kobayashi; T Fujii; M Maeda; Toshihiko Terao
[Bovine endothelial cell destruction by choriocarcinoma cell line (SMT-cc1) (inhibition of destruction by urinary trypsin inhibitor)].
Gan to kagaku ryoho. Cancer & chemotherapy 1993;20(8):1097-9.
1993: Hiroshi Kobayashi; N Moniwa; M Sugimura; H Shinohara; H Ohi; Toshihiko Terao
Increased cell-surface urokinase in advanced ovarian cancer.
Japanese journal of cancer research : Gann 1993;84(6):633-40.
1993: Hiroshi Kobayashi; M Tamura; T Satoh; Toshihiko Terao
Clinical evaluation of new cancer-associated antigen CA125 II in epithelial ovarian cancers: comparison with CA125.
Clinical biochemistry 1993;26(3):213-9.
1993: Hiroshi Kobayashi; W Ida; Toshihiko Terao; Y Kawashima
Quantitative and qualitative assessment of CA-125 production by human endometrial epithelial cells: comparison of eutopic and heterotopic epithelial cells.
International journal of cancer. Journal international du cancer 1993;54(3):426-34.
1993: H Ohi; Hiroshi Kobayashi; Toshihiko Terao
[A new histologic diagnosis for amniotic fluid embolism by monoclonal antibody TKH-2 that recognizes mucin-type glycoprotein].
Nihon Sanka Fujinka Gakkai zasshi 1993;45(5):464-70.
1993: Hiroshi Kobayashi; H Ohi; M Sugimura; H Shinohara; Toshihiko Terao
Monoclonal antibodies MA54 and MA61 as potential reagents in the prognosis of patients with ovarian cancer.
Gynecologic oncology 1993;49(1):80-5.
1993: Hiroshi Kobayashi; H Ohi; Toshihiko Terao
A simple, noninvasive, sensitive method for diagnosis of amniotic fluid embolism by monoclonal antibody TKH-2 that recognizes NeuAc alpha 2-6GalNAc.
American journal of obstetrics and gynecology 1993;168(3 Pt 1):848-53.
1993: Hiroshi Kobayashi; H Ohi; H Shinohara; Motoi Sugimura; T Fujii; Toshihiko Terao; Manfred Schmitt; L Goretzki; N Chucholowski; Fritz Jänicke
Saturation of tumour cell surface receptors for urokinase-type plasminogen activator by amino-terminal fragment and subsequent effect on reconstituted basement membranes invasion.
British journal of cancer 1993;67(3):537-44.
1992: Hiroshi Kobayashi; H Ohi; M Sugimura; H Shinohara; Toshihiko Terao
Characterization and clinical evaluation of tumor-associated antigen CA54/61 identified by monoclonal antibodies MA54 and MA61 in epithelial ovarian cancer.
Gynecologic oncology 1992;47(3):328-36.
1992: M Sugimura; Hiroshi Kobayashi; N Kanayama; Toshihiko Terao
Clinical significance of urokinase-type plasminogen activator (uPA) in invasive cervical cancer of the uterus.
Gynecologic oncology 1992;46(3):330-6.
1992: Hiroshi Kobayashi; H Ohi; M Sugimura; H Shinohara; T Fujii; Toshihiko Terao
Inhibition of in vitro ovarian cancer cell invasion by modulation of urokinase-type plasminogen activator and cathepsin B.
Cancer research 1992;52(13):3610-4.
1992: H Ohi; Hiroshi Kobayashi; M Sugimura; Toshihiko Terao
[A new method for diagnosis of amniotic fluid embolism by means of monoclonal antibody TKH-2 that recognizes mucin-type glycoprotein, a component in meconium].
Nihon Sanka Fujinka Gakkai zasshi 1992;44(7):813-9.
1992: M Sugimura; Hiroshi Kobayashi; Naohiro Kanayama; Toshihiko Terao
[Immunohistochemical study on the expression of epidermal growth factor receptor (EGF-R) in invasive cervical cancer of the uterus].
Nihon Sanka Fujinka Gakkai zasshi 1992;44(6):689-94.
1992: Hiroshi Kobayashi; W Ida; T Fujii; Toshihiko Terao; Y Kawashima
[Heterogeneity of CA 125 antigens released from human endometrial heterotopic epithelium and ovarian cancer].
Nihon Sanka Fujinka Gakkai zasshi 1992;44(5):571-6.
1992: Hiroshi Kobayashi; W Ida; Toshihiko Terao; Y Kawashima
[Qualitative assessment and characterization of CA125 antigen produced from human endometrial epithelial cells].
Nihon Sanka Fujinka Gakkai zasshi 1992;44(3):303-9.
1992: Hiroshi Kobayashi; Toshihiko Terao
[Field trial for the early detection of patients with ovarian cancer].
Rinsho byori. The Japanese journal of clinical pathology 1992;40(2):139-45.
1992: Hiroshi Kobayashi; K Sumimoto; Toshihiko Terao; Y Kawashima; K Okada
[Field trial for the early detection of patients with ovarian cancer--discrimination of ovarian cancer patients by the statistical analysis using Mahalanobis' generalized distance].
Nihon Sanka Fujinka Gakkai zasshi 1992;44(2):174-80.
1992: Hiroshi Kobayashi; Toshihiko Terao; Y Kawashima
Serum sialyl Tn as an independent predictor of poor prognosis in patients with epithelial ovarian cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1992;10(1):95-101.
1992: Hiroshi Kobayashi; Toshihiko Terao; Y Kawashima
[Serum sialyl Tn antigen as a prognostic marker in patients with epithelial ovarian cancer].
Nihon Sanka Fujinka Gakkai zasshi 1992;44(1):14-20.
1991: Hiroshi Kobayashi; H Ohi; Toshihiko Terao
Prevention by urinastatin of cis-diamminedichloroplatinum-induced nephrotoxicity in rabbits: comparison of urinary enzyme excretions and morphological alterations by electron microscopy.
Asia-Oceania journal of obstetrics and gynaecology / AOFOG 1991;17(3):277-88.
1991: Hiroshi Kobayashi; Toshihiko Terao; Y Kawashima
[Circulating serum STN antigen as a prognostic marker in epithelial ovarian cancer].
Gan to kagaku ryoho. Cancer & chemotherapy 1991;18(10):1651-5.
1991: Hiroshi Kobayashi; Toshihiko Terao; Y Kawashima
Clinical evaluation of circulating serum sialyl Tn antigen levels in patients with epithelial ovarian cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1991;9(6):983-7.
1991: Hiroshi Kobayashi; Manfred Schmitt; L Goretzki; N Chucholowski; J Calvete; M Kramer; W A Günzler; Fritz Jänicke; Henner Graeff
Cathepsin B efficiently activates the soluble and the tumor cell receptor-bound form of the proenzyme urokinase-type plasminogen activator (Pro-uPA).
The Journal of biological chemistry 1991;266(8):5147-52.
1991: Manfred Schmitt; L Goretzki; Fritz Jänicke; J Calvete; M Eulitz; Hiroshi Kobayashi; N Chucholowski; Henner Graeff
Biological and clinical relevance of the urokinase-type plasminogen activator (uPA) in breast cancer.
Biomedica biochimica acta 1991;50(4-6):731-41.
1990: W Ida; Hiroshi Kobayashi; Y Naito
[An in vitro study on the mechanism of CA125 production of endometrial cells--comparison of eutopic and heterotopic endometrium].
Nihon Sanka Fujinka Gakkai zasshi 1990;42(9):1161-7.
1990: Hiroshi Kobayashi; Y Kawashima
Clinical usefulness of serum sialyl SSEA-1 antigen levels in patients with epithelial ovarian cancer. Comparative effectiveness of sialyl SSEA-1 and CA 125.
Gynecologic and obstetric investigation 1990;30(1):52-8.
1989: Hiroshi Kobayashi; H Ishizuka; Y Hirashima; H Ohi; H Demukai; M Moniwa; M Maeda; Takao Kobayashi; Toshihiko Terao; Y Kawashima
[Preventive effect of urinastatin on cisplatin-induced nephrotoxicity].
Nihon Sanka Fujinka Gakkai zasshi 1989;41(12):1959-64.
1989: Hiroshi Kobayashi; T Hayata; Toshihiko Terao; Y Kawashima
[The study of cyclic maintenance chemotherapy with cisplatin, adriamycin, and cyclophosphamide (cyclic PAC chemotherapy) in patients with advanced ovarian cancer].
Nihon Sanka Fujinka Gakkai zasshi 1989;41(12):1936-42.
1989: Hiroshi Kobayashi; K Sumimoto; Toshihiko Terao; Y Kawashima
[Serodiagnostic tests by factor analysis and stepwise discriminating analysis with tumor markers for the detection of ovarian cancer].
Nihon Sanka Fujinka Gakkai zasshi 1989;41(12):1903-10.
1989: Hiroshi Kobayashi; Y Kawashima
[Prognosis estimation score in advanced ovarian cancer].
Nihon Sanka Fujinka Gakkai zasshi 1989;41(11):1783-90.
1989: Hiroshi Kobayashi; Y Kawashima
[Clinical usefulness of the combination assay of CA 125, SLX, and CA 72-4 in patients with ovarian cancer].
Nihon Sanka Fujinka Gakkai zasshi 1989;41(11):1731-5.
1989: Hiroshi Kobayashi; K Sumimoto; Toshihiko Terao; Y Kawashima; M Kouda
[Field trial of the early detection in patients with ovarian cancer].
Nihon Sanka Fujinka Gakkai zasshi 1989;41(11):1743-9.
1989: Hiroshi Kobayashi; K Sumimoto; Toshihiko Terao; Y Kawashima
[Diagnostic value of serological tumor marker tests in patients with ovarian cancer].
Nihon Sanka Fujinka Gakkai zasshi 1989;41(10):1501-6.
1989: Hiroshi Kobayashi; Y Kawashima
[A case of recurrent uterine cervical cancer successfully treated with etoposide].
Gan to kagaku ryoho. Cancer & chemotherapy 1989;16(9):3279-82.
1989: Hiroshi Kobayashi; H Ohi; Y Kawashima
[Prevention of cisplatin induced nephrotoxicity by administering urinastatin to rabbits--comparison with other protease inhibitors].
Nihon Sanka Fujinka Gakkai zasshi 1989;41(6):683-7.
1989: Hiroshi Kobayashi
[The clinical usefulness of serum CA72-4 analysis in patients with ovarian cancer].
Nihon Sanka Fujinka Gakkai zasshi 1989;41(5):585-9.
1989: Hiroshi Kobayashi
[Analysis of factors influencing prognosis in patients with advanced ovarian cancer].
Nihon Sanka Fujinka Gakkai zasshi 1989;41(5):564-70.
1989: Hiroshi Kobayashi
[Fundamental and clinical study on source of CA 125 antigen in cul-de-sac fluid and translation into systemic circulation].
Nihon Sanka Fujinka Gakkai zasshi 1989;41(4):390-6.
1989: Hiroshi Kobayashi
[Preventive effect of urinastatin on cisplatin induced nephrotoxicity in rabbits].
Nihon Sanka Fujinka Gakkai zasshi 1989;41(3):328-32.
1989: Hiroshi Kobayashi
[A study on the production of CA125 antigen using tissue culture of eutopic and heterotopic endometrium].
Nihon Sanka Fujinka Gakkai zasshi 1989;41(2):143-8.
1989: Hiroshi Kobayashi
[Clinical usefulness of serum sialyl Le(x)-i measurement in patients with ovarian cancer].
Nihon Sanka Fujinka Gakkai zasshi 1989;41(1):15-9.
1988: Hiroshi Kobayashi
[The clinical usefulness of the measurement of serum sialyl SSEA-1 antigen levels in patients with gynecologic diseases: as respects the comparative effectiveness of sialyl SSEA-1 and CA125].
Nihon Sanka Fujinka Gakkai zasshi 1988;40(7):828-34.
1988: Hiroshi Kobayashi; W Miyake; M Yamashita; Naohiro Kanayama; T Hayata; Y Kawashima
[The mechanism of the increase in the serum CA125 concentration in patients with endometriosis].
Nihon Sanka Fujinka Gakkai zasshi 1988;40(4):467-72.
1988: Hiroshi Kobayashi
[The effect of metoclopramide, dexamethasone and antihistamine in the prevention of PAC chemotherapy-induced emesis].
Nihon Sanka Fujinka Gakkai zasshi 1988;40(2):153-9.