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Gary Kobinger

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Oladele Ogunremi; John Pasick; Yohannes Berhane; Alfonso Clavijo; Drew Hannaman; Gary P Kobinger; Sylvia van Drunen Littel-van den Hurk
A single electroporation delivery of a DNA vaccine containing the hemagglutinin gene of Asian H5N1 avian influenza virus generated a protective antibody response in chickens against a North American virus strain.
Jason S Richardson; Stephane Pillet; Alexander J Bello; Gary P Kobinger
Airway delivery of an adenovirus-based Ebola virus vaccine bypasses existing immunity to homologous adenovirus in nonhuman primates.
Charles K Nfon; Greg Smith; Carissa Embury-Hyatt; Gary P Kobinger; Anders Leung; Hana Weingartl
Immunopathogenesis of Severe Acute Respiratory Disease in Zaire ebolavirus-Infected Pigs.

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All Publications

2013: Oladele Ogunremi; John Pasick; Yohannes Berhane; Alfonso Clavijo; Drew Hannaman; Gary P Kobinger; Sylvia van Drunen Littel-van den Hurk
A single electroporation delivery of a DNA vaccine containing the hemagglutinin gene of Asian H5N1 avian influenza virus generated a protective antibody response in chickens against a North American virus strain.
Clinical and vaccine immunology : CVI 2013;20(4):491-500.
2013: Jason S Richardson; Stephane Pillet; Alexander J Bello; Gary P Kobinger
Airway delivery of an adenovirus-based Ebola virus vaccine bypasses existing immunity to homologous adenovirus in nonhuman primates.
Journal of virology 2013;87(7):3668-77.
2013: Charles K Nfon; Greg Smith; Carissa Embury-Hyatt; Gary P Kobinger; Anders Leung; Hana Weingartl
Immunopathogenesis of Severe Acute Respiratory Disease in Zaire ebolavirus-Infected Pigs.
PloS one 2013;8(4):e61904.
2012: Charles K Nfon; John Pasick; Yohannes Berhane; Darwyn Kobasa; Gary P Kobinger; Shawn Babiuk
Prior infection of chickens with H1N1 avian influenza virus elicits heterologous protection against highly pathogenic H5N2.
Vaccine 2012;30(50):7187-92.
2012: Xuefei Shen; Jonas Söderholm; Alexander Bello; Kate E Broderick; Derek A Gregg; Gary P Kobinger; Feng Lin; Niranjan Y Sardesai
Influenza A vaccines using linear expression cassettes delivered via electroporation afford full protection against challenge in a mouse model.
Vaccine 2012;30(48):6946-54.
2012: Gary Wong; Yi Zhang; Judie B Alimonti; Heinz Feldmann; Robert Jeffrey Hogan; Ami Patel; Stephane Pillet; Xiangguo Qiu; Jason S Richardson; Ayato Takada; Gary P Kobinger
Immune parameters correlate with protection against ebola virus infection in rodents and nonhuman primates.
Science translational medicine 2012;4(158):158ra146.
2012: Allen Grolla; S Jones; Gary P Kobinger; C Roth; A Sprecher; H Artsob; H Feldmann; G Girard; M Yao; J E Strong
Flexibility of mobile laboratory unit in support of patient management during the 2007 Ebola-Zaire outbreak in the Democratic Republic of Congo.
Zoonoses and public health 2012;59 Suppl 2():151-7.
2012: Xiangguo Qiu; Jim E Strong; Gary Wong; Stephane Pillet; Frank Plummer; Judie B Alimonti; Jonathan Audet; Alexander Bello; Teresa Cabral; Cindy R Corbett; Gary P Kobinger
Successful treatment of ebola virus-infected cynomolgus macaques with monoclonal antibodies.
Science translational medicine 2012;4(138):138ra81.
2012: Feng Lin; Janess M Mendoza; Xuefei Shen; Jian Yan; Maria Yang; Philip Armendi; Alexander Bello; Kate E Broderick; Amir S Khan; Gleb Kichaev; Gary P Kobinger; Niranjan Y Sardesai
Optimization of electroporation-enhanced intradermal delivery of DNA vaccine using a minimally invasive surface device.
Human gene therapy methods 2012;23(3):157-68.
2012: Gary Wong; Gary P Kobinger
A strategy to simultaneously eradicate the natural reservoirs of rabies and Ebola virus.
Expert review of vaccines 2012;11(2):163-6.
2012: Isabelle Meunier; Francis Plummer; Shane Stebner; Nathalie Bastien; Carissa Embury-Hyatt; Michael Gray; Gary P Kobinger; Yan Li; Veronika von Messling
Virulence differences of closely related pandemic 2009 H1N1 isolates correlate with increased inflammatory responses in ferrets.
Virology 2012;422(1):125-31.
2012: Charles K Nfon; John Pasick; Yohannes Berhane; Carissa Embury-Hyatt; Darwyn Kobasa; Gary P Kobinger; Shawn Babiuk
Prior infection of chickens with H1N1 or H1N2 avian influenza elicits partial heterologous protection against highly pathogenic H5N1.
PloS one 2012;7(12):e51933.
2012: Hana Weingartl; Carissa Embury-Hyatt; Anders Leung; Charles K Nfon; Greg Smith; Gary P Kobinger
Transmission of Ebola virus from pigs to non-human primates.
Scientific reports 2012;2():811.
2012: Ami Patel; Jason S Richardson; Sarah Tohme; Brett Trost; Shawn Babiuk; Jessica C Dong; Sam K P Kung; Anthony Kusalik; Gary P Kobinger
Pentamers not found in the universal proteome can enhance antigen specific immune responses and adjuvant vaccines.
PloS one 2012;7(8):e43802.
2012: Xiangguo Qiu; Gary P Kobinger; Pasquale L Melito; Judie B Alimonti; Jonathan Audet; Heinz Feldmann; Lisa Fernando; Steven M Jones
Ebola GP-specific monoclonal antibodies protect mice and guinea pigs from lethal Ebola virus infection.
PLoS neglected tropical diseases 2012;6(3):e1575.
2011: Jason S Richardson; Beni M Sahai; Kaylie N Tran; Max C Abou; Anand Kumar; Gary P Kobinger
Impact of systemic or mucosal immunity to adenovirus on Ad-based Ebola virus vaccine efficacy in guinea pigs.
The Journal of infectious diseases 2011;204 Suppl 3():S1032-42.
2011: Zhujun Ao; Alexander Bello; Xi Chen; Keith Fowke; Xinying He; Kallesh Danappa Jayappa; Gary P Kobinger; Junhua Li; Xiaoxia Wang; Zhe Yu; Xiaojian Yao
Characterization of anti-HIV activity mediated by R88-APOBEC3G mutant fusion proteins in CD4+ T cells, peripheral blood mononuclear cells, and macrophages.
Human gene therapy 2011;22(10):1225-37.
2011: Stephane Pillet; Veronika von Messling; David B Weiner; Michael Gray; Darwyn Kobasa; Dominick Laddy; Isabelle Meunier; Gary P Kobinger
Cellular immune response in the presence of protective antibody levels correlates with protection against 1918 influenza in ferrets.
Vaccine 2011;29(39):6793-801.
2011: Gary P Kobinger; Anders Leung; James Neufeld; Ami Patel; Jason S Richardson; Greg Smith; Kevin Tierney; Darryl Falzarano; Hana M Weingartl
Replication, pathogenicity, shedding, and transmission of Zaire ebolavirus in pigs.
The Journal of infectious diseases 2011;204(2):200-8.
2010: Jason S Richardson; Joseph D Dekker; Maria A Croyle; Gary P Kobinger
Recent advances in Ebolavirus vaccine development.
Human vaccines 2010;6(6):439-49.
2010: Jennifer A Schwartz; Linda Buonocore; Amorsolo Suguitan; Alex Silaghi; Darwyn Kobasa; Gary P Kobinger; Heinz Feldmann; Kanta Subbarao; John K Rose
Potent vesicular stomatitis virus-based avian influenza vaccines provide long-term sterilizing immunity against heterologous challenge.
Journal of virology 2010;84(9):4611-8.
2010: Gary P Kobinger; Isabelle Meunier; Ami Patel; Stephane Pillet; Jason Gren; Shane Stebner; Anders Leung; James L Neufeld; Darwyn Kobasa; Veronika von Messling
Assessment of the efficacy of commercially available and candidate vaccines against a pandemic H1N1 2009 virus.
The Journal of infectious diseases 2010;201(7):1000-6.
2009: David Safronetz; Nagendra R Hegde; Hideki Ebihara; Michael Denton; Gary P Kobinger; Stephen St Jeor; Heinz Feldmann; David C Johnson
Adenovirus vectors expressing hantavirus proteins protect hamsters against lethal challenge with andes virus.
Journal of virology 2009;83(14):7285-95.
2009: Ami Patel; Kaylie Tran; Michael Gray; Yan Li; Zhujun Ao; Xiaojian Yao; Darwyn Kobasa; Gary P Kobinger
Evaluation of conserved and variable influenza antigens for immunization against different isolates of H5N1 viruses.
Vaccine 2009;27(23):3083-9.
2009: Jason S Richardson; Michel K Yao; Kaylie N Tran; Maria A Croyle; James E Strong; Heinz Feldmann; Gary P Kobinger
Enhanced protection against Ebola virus mediated by an improved adenovirus-based vaccine.
PloS one 2009;4(4):e5308.
2008: James E Strong; Gary Wong; Shane E Jones; Allen Grolla; Steven Theriault; Gary P Kobinger; Heinz Feldmann
Stimulation of Ebola virus production from persistent infection through activation of the Ras/MAPK pathway.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(46):17982-7.
2008: Zhujun Ao; Ami Patel; Kaylie Tran; Xinying He; Keith Fowke; Kevin M Coombs; Darwyn Kobasa; Gary P Kobinger; Xiaojian Yao
Characterization of a trypsin-dependent avian influenza H5N1-pseudotyped HIV vector system for high throughput screening of inhibitory molecules.
Antiviral research 2008;79(1):12-8.
2008: Maria A Croyle; Ami Patel; Kaylie N Tran; Michael Gray; Yi Zhang; James E Strong; Heinz Feldmann; Gary P Kobinger
Nasal delivery of an adenovirus-based vaccine bypasses pre-existing immunity to the vaccine carrier and improves the immune response in mice.
PloS one 2008;3(10):e3548.
2008: Dominick J Laddy; Jian Yan; Michele A Kutzler; Darwyn Kobasa; Gary P Kobinger; Amir S Khan; Jack Greenhouse; Niranjan Y Sardesai; Ruxandra Draghia-Akli; David B Weiner
Heterosubtypic protection against pathogenic human and avian influenza viruses via in vivo electroporation of synthetic consensus DNA antigens.
PloS one 2008;3(6):e2517.
2007: Ami Patel; Yi Zhang; Maria Croyle; Kaylie Tran; Michael Gray; Jim Strong; Heinz Feldmann; James M Wilson; Gary P Kobinger
Mucosal delivery of adenovirus-based vaccine protects against Ebola virus infection in mice.
The Journal of infectious diseases 2007;196 Suppl 2():S413-20.
2007: Soumitra Roy; Gary P Kobinger; Jianping Lin; Joanita Figueredo; Roberto Calcedo; Darwyn Kobasa; James M Wilson
Partial protection against H5N1 influenza in mice with a single dose of a chimpanzee adenovirus vector expressing nucleoprotein.
Vaccine 2007;25(39-40):6845-51.
2007: Jennifer A Schwartz; Linda Buonocore; Anjeanette Roberts; Amorsolo Suguitan; Darwyn Kobasa; Gary P Kobinger; Heinz Feldmann; Kanta Subbarao; John K Rose
Vesicular stomatitis virus vectors expressing avian influenza H5 HA induce cross-neutralizing antibodies and long-term protection.
Virology 2007;366(1):166-73.
2007: Gary P Kobinger; Joanita Figueredo; Thomas Rowe; Yan Zhi; Guangping Gao; Julio Sanmiguel; Peter Bell; Nelson A Wivel; Lois A Zitzow; Douglas B Flieder; Robert Jeffrey Hogan; James M Wilson
Adenovirus-based vaccine prevents pneumonia in ferrets challenged with the SARS coronavirus and stimulates robust immune responses in macaques.
Vaccine 2007;25(28):5220-31.
2007: Gary P Kobinger; Maria P Limberis; Suri Somanathan; Gregory Schumer; Peter Bell; James M Wilson
Human immunodeficiency viral vector pseudotyped with the spike envelope of severe acute respiratory syndrome coronavirus transduces human airway epithelial cells and dendritic cells.
Human gene therapy 2007;18(5):413-22.
2007: Dominick J Laddy; Jian Yan; Natasha Corbitt; Darwyn Kobasa; Gary P Kobinger; David B Weiner
Immunogenicity of novel consensus-based DNA vaccines against avian influenza.
Vaccine 2007;25(16):2984-9.
2006: Soumitra Roy; Yan Zhi; Gary P Kobinger; Joanita Figueredo; Roberto Calcedo; James R Miller; Heinz Feldmann; James M Wilson
Generation of an adenoviral vaccine vector based on simian adenovirus 21.
The Journal of general virology 2006;87(Pt 9):2477-85.
2006: Yan Zhi; Joanita Figueredo; Gary P Kobinger; Heather Hagan; Roberto Calcedo; James R Miller; Guangping Gao; James M Wilson
Efficacy of severe acute respiratory syndrome vaccine based on a nonhuman primate adenovirus in the presence of immunity against human adenovirus.
Human gene therapy 2006;17(5):500-6.
2006: Gary P Kobinger; Heinz Feldmann; Yan Zhi; Gregory Schumer; Guangping Gao; Friederike Feldmann; Steven Jones; James M Wilson
Chimpanzee adenovirus vaccine protects against Zaire Ebola virus.
Virology 2006;346(2):394-401.
2005: Ester Zito; Alessandro Fraldi; Stefano Pepe; Ida Annunziata; Gary P Kobinger; Paola Di Natale; Andrea Ballabio; Maria Pia Cosma
Sulphatase activities are regulated by the interaction of sulphatase-modifying factor 1 with SUMF2.
EMBO reports 2005;6(7):655-60.
2005: Yan Zhi; Gary P Kobinger; Heather Jordan; Katie Suchma; Susan R Weiss; Hao Shen; Gregory Schumer; Guangping Gao; Julie L Boyer; Ronald G Crystal; James M Wilson
Identification of murine CD8 T cell epitopes in codon-optimized SARS-associated coronavirus spike protein.
Virology 2005;335(1):34-45.
2005: Julie L Boyer; Gary P Kobinger; James M Wilson; Helen-Ann Brown Epstein
Adenovirus-based genetic vaccines for biodefense.
Human gene therapy 2005;16(2):157-68.
2005: Gary P Kobinger; Shaoping Deng; Jean-Pierre Louboutin; Marko Z Vatamaniuk; Victor M Rivera; Moh-Moh Lian; James F Markmann; Tim Clackson; Steven E Raper; Franz M Matschinsky; James M Wilson
Pharmacologically regulated regeneration of functional human pancreatic islets.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;11(1):105-11.
2005: Tippi C Mackenzie; Gary P Kobinger; Jean-Pierre Louboutin; Antoneta Radu; Elizabeth H Javazon; Miguel Sena-Esteves; James M Wilson; Alan W Flake
Transduction of satellite cells after prenatal intramuscular administration of lentiviral vectors.
The journal of gene medicine 2005;7(1):50-8.
2004: Robert Jeffrey Hogan; Guangping Gao; Thomas Rowe; Peter Bell; Douglas B Flieder; Jason Paragas; Gary P Kobinger; Nelson A Wivel; Ronald G Crystal; Julie Boyer; Heinz Feldmann; Thomas G Voss; James M Wilson
Resolution of primary severe acute respiratory syndrome-associated coronavirus infection requires Stat1.
Journal of virology 2004;78(20):11416-21.
2004: Thomas Rowe; Guangping Gao; Robert Jeffrey Hogan; Ronald G Crystal; Thomas G Voss; Rebecca L Grant; Peter Bell; Gary P Kobinger; Nelson A Wivel; James M Wilson
Macaque model for severe acute respiratory syndrome.
Journal of virology 2004;78(20):11401-4.
2004: Gary P Kobinger; Shaoping Deng; Jean-Pierre Louboutin; Marko Z Vatamaniuk; Franz M Matschinsky; James F Markmann; Steven E Raper; James M Wilson
Transduction of human islets with pseudotyped lentiviral vectors.
Human gene therapy 2004;15(2):211-9.
2004: Maria A Croyle; Shellie M Callahan; Alberto Auricchio; Gregg Schumer; Klaus D Linse; James M Wilson; Lane J Brunner; Gary P Kobinger
PEGylation of a vesicular stomatitis virus G pseudotyped lentivirus vector prevents inactivation in serum.
Journal of virology 2004;78(2):912-21.
2003: Maria Fe Medina; Gary P Kobinger; John Rux; Mehdi Gasmi; David J Looney; Paul Bates; James M Wilson
Lentiviral vectors pseudotyped with minimal filovirus envelopes increased gene transfer in murine lung.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;8(5):777-89.
2003: Gary P Kobinger; Jean-Pierre Louboutin; Elisabeth R Barton; H Lee Sweeney; James M Wilson
Correction of the dystrophic phenotype by in vivo targeting of muscle progenitor cells.
Human gene therapy 2003;14(15):1441-9.
2003: Foong-Yen Lim; Gary P Kobinger; Daniel J Weiner; Antoneta Radu; James M Wilson; Timothy M Crombleholme
Human fetal trachea-SCID mouse xenografts: efficacy of vesicular stomatitis virus-G pseudotyped lentiviral-mediated gene transfer.
Journal of pediatric surgery 2003;38(6):834-9.
2003: Kenneth R Hallows; Gary P Kobinger; James M Wilson; Lee A Witters; J Kevin Foskett
Physiological modulation of CFTR activity by AMP-activated protein kinase in polarized T84 cells.
American journal of physiology. Cell physiology 2003;284(5):C1297-308.
2002: Tippi C Mackenzie; Gary P Kobinger; Neeltje Kootstra; Antoneta Radu; Miguel Sena-Esteves; Sarah Bouchard; James M Wilson; Inder M Verma; Alan W Flake
Efficient transduction of liver and muscle after in utero injection of lentiviral vectors with different pseudotypes.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(3):349-58.
2002: Deborah J Watson; Gary P Kobinger; Marco A Passini; James M Wilson; John H Wolfe
Targeted transduction patterns in the mouse brain by lentivirus vectors pseudotyped with VSV, Ebola, Mokola, LCMV, or MuLV envelope proteins.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(5 Pt 1):528-37.
2001: Gary P Kobinger; Daniel J Weiner; Qian-Chun Yu; James M Wilson
Filovirus-pseudotyped lentiviral vector can efficiently and stably transduce airway epithelia in vivo.
Nature biotechnology 2001;19(3):225-30.