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Friedrich Koch-Nolte

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Sahil Adriouch; Olivier Boyer; Friedrich Haag; Michel Seman; Friedrich Koch-Nolte
Extracellular NAD(+): a danger signal hindering regulatory T cells.
Anselm Sommer; Nancy Speck; Jörg Andrä; Sucharit Bhakdi; Isabell Cornelsen; Anja Fries; Gerald Gimpl; Friedrich Koch-Nolte; Karina Reiss
Melittin modulates keratinocyte function through P2 receptor-dependent ADAM activation.
Nicole Schwarz; Annette Nicke; Sahil Adriouch; Olivier Boyer; Laurent Drouot; Ralf Fliegert; Andreas H Guse; Friedrich Haag; Friedrich Koch-Nolte
Alternative splicing of the N-terminal cytosolic and transmembrane domains of P2X7 controls gating of the ion channel by ADP-ribosylation.

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All Publications

2012: Sahil Adriouch; Olivier Boyer; Friedrich Haag; Michel Seman; Friedrich Koch-Nolte
Extracellular NAD(+): a danger signal hindering regulatory T cells.
Microbes and infection / Institut Pasteur 2012;14(14):1284-92.
2012: Anselm Sommer; Nancy Speck; Jörg Andrä; Sucharit Bhakdi; Isabell Cornelsen; Anja Fries; Gerald Gimpl; Friedrich Koch-Nolte; Karina Reiss
Melittin modulates keratinocyte function through P2 receptor-dependent ADAM activation.
The Journal of biological chemistry 2012;287(28):23678-89.
2012: Nicole Schwarz; Annette Nicke; Sahil Adriouch; Olivier Boyer; Laurent Drouot; Ralf Fliegert; Andreas H Guse; Friedrich Haag; Friedrich Koch-Nolte
Alternative splicing of the N-terminal cytosolic and transmembrane domains of P2X7 controls gating of the ion channel by ADP-ribosylation.
PloS one 2012;7(7):e41269.
2011: Sabrina Laing; Friedrich Haag; Friedrich Koch-Nolte; Friedrich Buck
Strategies for the identification of arginine ADP-ribosylation sites.
Journal of proteomics 2011;75(1):169-76.
2011: Jörg Behnke; Friedrich Haag; Friedrich Koch-Nolte; Paul Saftig; Janna Schneppenheim; Bernd Schröder
Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail.
FEBS letters 2011;585(19):2951-7.
2011: Peter Bannas; Friedrich Haag; Irm Hermans-Borgmeyer; Felix Scheuplein; Lennart Well; Friedrich Koch-Nolte
Transgenic overexpression of toxin-related ecto-ADP-ribosyltransferase ART2.2 sensitizes T cells but not B cells to NAD-induced cell death.
Molecular immunology 2011;48(15-16):1762-70.
2011: Karla Juarez; Friedrich Koch-Nolte; Friedrich Buck; Gudrun Dubberke; Friedrich Haag; Pavel Lugo; Alexei Licea
Monoclonal antibodies for the identification and purification of vNAR domains and IgNAR immunoglobulins from the horn shark Heterodontus francisci.
Hybridoma (2005) 2011;30(4):323-9.
2011: Sabrina Laing; Mandy Unger; Friedrich Koch-Nolte; Friedrich Haag
ADP-ribosylation of arginine.
Amino acids 2011;41(2):257-69.
2011: Friedrich Koch-Nolte; Stefan Fischer; Friedrich Haag; Mathias Ziegler
Compartmentation of NAD+-dependent signalling.
FEBS letters 2011;585(11):1651-6.
2011: Christoph Garbers; Nathalie Jänner; Athena Chalaris; Marcia L Moss; Doreen M Floss; Dörte Meyer; Friedrich Koch-Nolte; Stefan Rose-John; Jürgen Scheller
Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding.
The Journal of biological chemistry 2011;286(17):14804-11.
2011: Vanina Alzogaray; Welbeck Danquah; Andrés Aguirre; Mariela Urrutia; Paula Berguer; Eleonora García Véscovi; Friedrich Haag; Friedrich Koch-Nolte; Fernando A Goldbaum
Single-domain llama antibodies as specific intracellular inhibitors of SpvB, the actin ADP-ribosylating toxin of Salmonella typhimurium.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(2):526-34.
2011: Chi-un Choe; Kerstin Lardong; Mathias Gelderblom; Peter Ludewig; Frank Leypoldt; Friedrich Koch-Nolte; Christian Gerloff; Tim Magnus
CD38 exacerbates focal cytokine production, postischemic inflammation and brain injury after focal cerebral ischemia.
PloS one 2011;6(5):e19046.
2011: Michael Hottiger; Mark Boothby; Friedrich Koch-Nolte; Bernhard Lüscher; Niall M B Martin; Ruth Plummer; Zhao-Qi Wang; Mathias Ziegler
Progress in the function and regulation of ADP-Ribosylation.
Science signaling 2011;4(174):mr5.
2010: Sandra Hubert; Björn Rissiek; Katjana Klages; Jochen Huehn; Tim D. Sparwasser; Friedrich Haag; Friedrich Koch-Nolte; Olivier Boyer; Michel Seman; Sahil Adriouch
Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway.
The Journal of experimental medicine 2010;207(12):2561-8.
2010: Peter Bannas; Oliver Graumann; Philipp Balcerak; Kersten Peldschus; Michael Gerhard Kaul; Heinrich Hohenberg; Friedrich Haag; Gerhard Adam; Harald Ittrich; Friedrich Koch-Nolte
Quantitative magnetic resonance imaging of enzyme activity on the cell surface: in vitro and in vivo monitoring of ADP-ribosyltransferase 2 on T cells.
Molecular imaging 2010;9(4):211-22.
2010: Michael O Hottiger; Paul O Hassa; Bernhard Lüscher; Herwig Schüler; Friedrich Koch-Nolte
Toward a unified nomenclature for mammalian ADP-ribosyltransferases.
Trends in biochemical sciences 2010;35(4):208-19.
2010: Felix Scheuplein; Björn Rissiek; John P Driver; Yi-Guang Chen; Friedrich Koch-Nolte; David V Serreze
A recombinant heavy chain antibody approach blocks ART2 mediated deletion of an iNKT cell population that upon activation inhibits autoimmune diabetes.
Journal of autoimmunity 2010;34(2):145-54.
2009: Hanna Erdmann; Christiane Steeg; Friedrich Koch-Nolte; Bernhard Fleischer; Thomas Jacobs
Sialylated ligands on pathogenic Trypanosoma cruzi interact with Siglec-E (sialic acid-binding Ig-like lectin-E).
Cellular microbiology 2009;11(11):1600-11.
2009: Shiyuan Hong; Anette Brass; Michel Seman; Friedrich Haag; Friedrich Koch-Nolte; George R Dubyak
Basal and inducible expression of the thiol-sensitive ART2.1 ecto-ADP-ribosyltransferase in myeloid and lymphoid leukocytes.
Purinergic signalling 2009;5(3):369-83.
2009: Janusz Wesolowski; Vanina Alzogaray; Jan Reyelt; Mandy Unger; Karla Juarez; Mariela Urrutia; Ana Cauerhff; Welbeck Danquah; Björn Rissiek; Felix Scheuplein; Nicole Schwarz; Sahil Adriouch; Olivier Boyer; Michel Seman; Alexei Licea; David V Serreze; Fernando A Goldbaum; Friedrich Haag; Friedrich Koch-Nolte
Single domain antibodies: promising experimental and therapeutic tools in infection and immunity.
Medical microbiology and immunology 2009;198(3):157-74.
2009: Shiyuan Hong; Nicole Schwarz; Anette Brass; Michel Seman; Friedrich Haag; Friedrich Koch-Nolte; William P Schilling; George R Dubyak
Differential regulation of P2X7 receptor activation by extracellular nicotinamide adenine dinucleotide and ecto-ADP-ribosyltransferases in murine macrophages and T cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(1):578-92.
2009: Nicole Schwarz; Ralf Fliegert; Sahil Adriouch; Michel Seman; Andreas H Guse; Friedrich Haag; Friedrich Koch-Nolte
Activation of the P2X7 ion channel by soluble and covalently bound ligands.
Purinergic signalling 2009;5(2):139-49.
2009: Sahil Adriouch; Felix Scheuplein; Robert Bähring; Michel Seman; Olivier Boyer; Friedrich Koch-Nolte; Friedrich Haag
Characterisation of the R276A gain-of-function mutation in the ectodomain of murine P2X7.
Purinergic signalling 2009;5(2):151-61.
2009: Stefan Kernstock; Friedrich Koch-Nolte; Jochen Mueller-Dieckmann; Manfred S Weiss; Christoph Mueller-Dieckmann
Cloning, expression, purification and crystallization as well as X-ray fluorescence and preliminary X-ray diffraction analyses of human ADP-ribosylhydrolase 1.
Acta crystallographica. Section F, Structural biology and crystallization communications 2009;65(Pt 5):529-32.
2009: Elena Bulanova; Vadim Budagian; Zane Orinska; Friedrich Koch-Nolte; Friedrich Haag; Silvia Bulfone-Paus
ATP induces P2X7 receptor-independent cytokine and chemokine expression through P2X1 and P2X3 receptors in murine mast cells.
Journal of leukocyte biology 2009;85(4):692-702.
2009: Felix Scheuplein; Nicole Schwarz; Sahil Adriouch; Christian Krebs; Peter Bannas; Björn Rissiek; Michel Seman; Friedrich Haag; Friedrich Koch-Nolte
NAD+ and ATP released from injured cells induce P2X7-dependent shedding of CD62L and externalization of phosphatidylserine by murine T cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(5):2898-908.
2009: Jenny Schröder; Renate Lüllmann-Rauch; Nina Himmerkus; Irina Pleines; Bernhard Nieswandt; Zane Orinska; Friedrich Koch-Nolte; Bernd Schröder; Markus Bleich; Paul Saftig
Deficiency of the tetraspanin CD63 associated with kidney pathology but normal lysosomal function.
Molecular and cellular biology 2009;29(4):1083-94.
2009: Friedrich Koch-Nolte; Friedrich Haag; Andreas H Guse; Frances Lund; Mathias Ziegler
Emerging roles of NAD+ and its metabolites in cell signaling.
Science signaling 2009;2(57):mr1.
2008: Kirsten Heiss; Nathalie Jänner; Birgit Mähnss; Valéa Schumacher; Friedrich Koch-Nolte; Friedrich Haag; Hans-Willi Mittrücker
High sensitivity of intestinal CD8+ T cells to nucleotides indicates P2X7 as a regulator for intestinal T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(6):3861-9.
2008: Christoph Mueller-Dieckmann; Stefan Kernstock; Jochen Mueller-Dieckmann; Manfred S Weiss; Friedrich Koch-Nolte
Structure of mouse ADP-ribosylhydrolase 3 (mARH3).
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 3):156-62.
2008: Sahil Adriouch; Peter Bannas; Nicole Schwarz; Ralf Fliegert; Andreas H Guse; Michel Seman; Friedrich Haag; Friedrich Koch-Nolte
ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(3):861-9.
2008: Friedrich Koch-Nolte; Stefan Kernstock; Christoph Mueller-Dieckmann; Manfred S Weiss; Friedrich Haag
Mammalian ADP-ribosyltransferases and ADP-ribosylhydrolases.
Frontiers in bioscience : a journal and virtual library 2008;13():6716-29.
2008: Marc Niere; Stefan Kernstock; Friedrich Koch-Nolte; Mathias Ziegler
Functional localization of two poly(ADP-ribose)-degrading enzymes to the mitochondrial matrix.
Molecular and cellular biology 2008;28(2):814-24.
2007: Shiyuan Hong; Anette Brass; Michel Seman; Friedrich Haag; Friedrich Koch-Nolte; George R Dubyak
Lipopolysaccharide, IFN-gamma, and IFN-beta induce expression of the thiol-sensitive ART2.1 Ecto-ADP-ribosyltransferase in murine macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(9):6215-27.
2007: Friedrich Koch-Nolte; Jan Reyelt; Britta Schössow; Nicole Schwarz; Felix Scheuplein; Stefan Rothenburg; Friedrich Haag; Vanina Alzogaray; Ana Cauerhff; Fernando A Goldbaum
Single domain antibodies from llama effectively and specifically block T cell ecto-ADP-ribosyltransferase ART2.2 in vivo.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(13):3490-8.
2007: Sina Möller; Caroline Jung; Sahil Adriouch; Gudrun Dubberke; Fabienne Seyfried; Michel Seman; Friedrich Haag; Friedrich Koch-Nolte
Monitoring the expression of purinoceptors and nucleotide-metabolizing ecto-enzymes with antibodies directed against proteins in native conformation.
Purinergic signalling 2007;3(4):359-66.
2007: Sahil Adriouch; Sandra Hubert; Severine Pechberty; Friedrich Koch-Nolte; Friedrich Haag; Michel Seman
NAD+ released during inflammation participates in T cell homeostasis by inducing ART2-mediated death of naive T cells in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(1):186-94.
2007: Friedrich Haag; Caroline Jung; Sahil Adriouch; Peter Bannas; Anette Braß; Sina Möller; Felix Scheuplein; Michel Seman; Friedrich Koch-Nolte
Extracellular NAD and ATP: Partners in immune cell modulation.
Purinergic signalling 2007;3(1-2):71-81.
2007: Birte Kretschmer; Katja Lüthje; Andreas H Guse; Svenja Ehrlich; Friedrich Koch-Nolte; Friedrich Haag; Bernhard Fleischer; Minka Breloer
CD83 modulates B cell function in vitro: increased IL-10 and reduced Ig secretion by CD83Tg B cells.
PloS one 2007;2(8):e755.
2007: Sonja Schrepfer; Tobias Deuse; Friedrich Koch-Nolte; Thorsten Krieger; Munif Haddad; Hansjörg Schäfer; Marc P Pelletier; Robert C Robbins; Hermann Reichenspurner
FK778 in experimental xenotransplantation: a detailed analysis of drug efficacy.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2007;26(1):70-7.
2006: Richard Billington; Santina Bruzzone; Antonio De Flora; Armando Genazzani; Friedrich Koch-Nolte; Mathias Ziegler; Elena Zocchi
Emerging functions of extracellular pyridine nucleotides.
Molecular medicine (Cambridge, Mass.) 2006;12(11-12):324-7.
2006: Christoph Mueller-Dieckmann; Stefan Kernstock; Michael Lisurek; Jens Peter von Kries; Friedrich Haag; Manfred S Weiss; Friedrich Koch-Nolte
The structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylation.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(41):15026-31.
2006: Maik Friedrich; Andreas Grahnert; Uwe Paasch; Andrea Tannapfel; Friedrich Koch-Nolte; Sunna Hauschildt
Expression of toxin-related human mono-ADP-ribosyltransferase 3 in human testes.
Asian journal of andrology 2006;8(3):281-7.
2006: Jing Chen; Yi-Guang Chen; Peter C Reifsnyder; William H Schott; Chul-Ho Lee; Melissa Osborne; Felix Scheuplein; Friedrich Haag; Friedrich Koch-Nolte; David V Serreze; Edward H Leiter
Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(8):4590-9.
2006: Sonja Schrepfer; Tobias Deuse; Friedrich Koch-Nolte; Christian Detter; Hermann Reichenspurner
FK778: new cellular and molecular mechanisms of action.
Transplantation proceedings 2006;38(3):757-61.
2006: Tobias Deuse; Sonja Schrepfer; Friedrich Koch-Nolte; Munif Haddad; Hansjörg Schäfer; Christian Detter; Hermann Reichenspurner
Sirolimus and FK778: a comparison of two anti-proliferative immunosuppressants for prevention of experimental obliterative airway disease.
Transplant international : official journal of the European Society for Organ Transplantation 2006;19(4):310-8.
2006: Stefan Kernstock; Friedrich Koch-Nolte; Jochen Mueller-Dieckmann; Manfred S Weiss; Christoph Mueller-Dieckmann
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of human ARH3, the first eukaryotic protein-ADP-ribosylhydrolase.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 3):224-7.
2006: Nikolaus Deigendesch; Friedrich Koch-Nolte; Stefan Rothenburg
ZBP1 subcellular localization and association with stress granules is controlled by its Z-DNA binding domains.
Nucleic acids research 2006;34(18):5007-20.
2006: Friedrich Koch-Nolte; Sahil Adriouch; Peter Bannas; Christian Krebs; Felix Scheuplein; Michel Seman; Friedrich Haag
ADP-ribosylation of membrane proteins: unveiling the secrets of a crucial regulatory mechanism in mammalian cells.
Annals of medicine 2006;38(3):188-99.
2005: Tobias Deuse; Sonja Schrepfer; Friedrich Koch-Nolte; Munif Haddad; Edzard Schwedhelm; Rainer H Böger; Hansjörg Schäfer; Christian Detter; Hermann Reichenspurner
FK778 and tacrolimus prevent the development of obliterative airway disease after heterotopic rat tracheal transplantation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2005;24(11):1844-54.
2005: Stefan Rothenburg; Friedrich Haag; Friedrich Koch-Nolte; Christine Carter; Margaret Graham; Geoffrey W Butcher
Characterization of multiple alleles of the T-cell differentiation marker ART2 (RT6) in inbred and wild rats.
Immunogenetics 2005;57(10):739-49.
2005: Jing Chen; Peter C Reifsnyder; Felix Scheuplein; William H Schott; Maria Mileikovsky; Sharon Soodeen-Karamath; Andras Nagy; Michael H Dosch; James Ellis; Friedrich Koch-Nolte; Edward H Leiter
"Agouti NOD": identification of a CBA-derived Idd locus on Chromosome 7 and its use for chimera production with NOD embryonic stem cells.
Mammalian genome : official journal of the International Mammalian Genome Society 2005;16(10):775-83.
2005: Sonja Schrepfer; Tobias Deuse; Hansjörg Schäfer; Friedrich Koch-Nolte; Wilhelm Braendle; Hermann Reichenspurner
The phytoestrogen biochaninA weakens acute cardiac allograft rejection without affecting the reproductive system.
Transplant immunology 2005;15(1):45-53.
2005: Chris McKinnell; Richard M Sharpe; Kim Mahood; Nina Hallmark; Hayley Scott; Richard Ivell; Christophe Staub; Bernard Jégou; Friedrich Haag; Friedrich Koch-Nolte; Stefan Hartung
Expression of insulin-like factor 3 protein in the rat testis during fetal and postnatal development and in relation to cryptorchidism induced by in utero exposure to di (n-Butyl) phthalate.
Endocrinology 2005;146(10):4536-44.
2005: Friedrich Koch-Nolte; Gustavo Glowacki; Peter Bannas; Fenja Braasch; Gudrun Dubberke; Erika Ortolan; Ada Funaro; Fabio Malavasi; Friedrich Haag
Use of genetic immunization to raise antibodies recognizing toxin-related cell surface ADP-ribosyltransferases in native conformation.
Cellular immunology 2005;236(1-2):66-71.
2005: Ines Parusel; Sarah Kahl; Fenja Braasch; Gustavo Glowacki; Gregory R Halverson; Marion E Reid; Alissa Schawalder; Erika Ortolan; Ada Funaro; Fabio Malavasi; Debbie Hardie; Sapna Halder; Christopher D Buckley; Friedrich Haag; Friedrich Koch-Nolte
A panel of monoclonal antibodies recognizing GPI-anchored ADP-ribosyltransferase ART4, the carrier of the Dombrock blood group antigens.
Cellular immunology 2005;236(1-2):59-65.
2005: Sahil Adriouch; Gudrun Dubberke; Philip Diessenbacher; François Rassendren; Michel Seman; Friedrich Haag; Friedrich Koch-Nolte
Probing the expression and function of the P2X7 purinoceptor with antibodies raised by genetic immunization.
Cellular immunology 2005;236(1-2):72-7.
2005: Peter Bannas; Sahil Adriouch; Sarah Kahl; Fenja Braasch; Friedrich Haag; Friedrich Koch-Nolte
Activity and specificity of toxin-related mouse T cell ecto-ADP-ribosyltransferase ART2.2 depends on its association with lipid rafts.
Blood 2005;105(9):3663-70.
2005: Christian Krebs; Sahil Adriouch; Fenja Braasch; Wolfgang Koestner; Edward H Leiter; Michel Seman; Frances E Lund; Norman Oppenheimer; Friedrich Haag; Friedrich Koch-Nolte
CD38 controls ADP-ribosyltransferase-2-catalyzed ADP-ribosylation of T cell surface proteins.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(6):3298-305.
2005: Hiroki Kawamura; Fred Aswad; Masahiro Minagawa; Karen Malone; Harvey Kaslow; Friedrich Koch-Nolte; William H Schott; Edward H Leiter; Gunther Dennert
P2X7 receptor-dependent and -independent T cell death is induced by nicotinamide adenine dinucleotide.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(4):1971-9.
2005: Stefan Rothenburg; Nikolaus Deigendesch; Katharina Dittmar; Friedrich Koch-Nolte; Friedrich Haag; Ky Lowenhaupt; Alexander Rich
A PKR-like eukaryotic initiation factor 2alpha kinase from zebrafish contains Z-DNA binding domains instead of dsRNA binding domains.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(5):1602-7.
2005: Helge Otto; Pedro A Reche; J. Fernando Bazan; Katharina Dittmar; Friedrich Haag; Friedrich Koch-Nolte
In silico characterization of the family of PARP-like poly(ADP-ribosyl)transferases (pARTs).
BMC genomics 2005;6():139.
2004: Tobias Deuse; Sonja Schrepfer; Hansjörg Schäfer; Friedrich Koch-Nolte; Edzard Schwedhelm; Rainer H Böger; Hermann Reichenspurner
FK778 attenuates lymphocyte-endothelium interaction after cardiac transplantation: in vivo and in vitro studies.
Transplantation 2004;78(1):71-7.
2004: Michel Seman; Sahil Adriouch; Friedrich Haag; Friedrich Koch-Nolte
Ecto-ADP-ribosyltransferases (ARTs): emerging actors in cell communication and signaling.
Current medicinal chemistry 2004;11(7):857-72.
2003: Philip Diessenbacher; Katrin Bartels; Friedrich Koch-Nolte; Friedrich Haag
T-cell survival regulator LKLF is not involved in inappropriate apoptosis of diabetes-prone BBDP rat T cells.
Annals of the New York Academy of Sciences 2003;1010():548-51.
2003: Felix Scheuplein; Sahil Adriouch; Gustavo Glowacki; Friedrich Haag; Michel Seman; Friedrich Koch-Nolte
Triggering of T-cell apoptosis by toxin-related ecto-ADP-ribosyltransferase ART2.
Annals of the New York Academy of Sciences 2003;1010():296-9.
2003: Michel Seman; Sahil Adriouch; Felix Scheuplein; Christian Krebs; Dunja Freese; Gustavo Glowacki; Phillipe Deterre; Friedrich Haag; Friedrich Koch-Nolte
NAD-induced T cell death: ADP-ribosylation of cell surface proteins by ART2 activates the cytolytic P2X7 purinoceptor.
Immunity 2003;19(4):571-82.
2003: Holger Ritter; Friedrich Koch-Nolte; Victor E Marquez; Georg E Schulz
Substrate binding and catalysis of ecto-ADP-ribosyltransferase 2.2 from rat.
Biochemistry 2003;42(34):10155-62.
2003: Svenja Kunerth; Georg W Mayr; Friedrich Koch-Nolte; Andreas H Guse
Analysis of subcellular calcium signals in T-lymphocytes.
Cellular signalling 2003;15(8):783-92.
2003: Christian Krebs; Wolfgang Koestner; Marion Nissen; Vivienne Welge; Ines Parusel; Fabio Malavasi; Edward H Leiter; Regina M Santella; Friedrich Haag; Friedrich Koch-Nolte
Flow cytometric and immunoblot assays for cell surface ADP-ribosylation using a monoclonal antibody specific for ethenoadenosine.
Analytical biochemistry 2003;314(1):108-15.
2002: Friedrich Haag; Dunja Freese; Felix Scheublein; Wiebke Ohlrogge; Sahil Adriouch; Michel Seman; Friedrich Koch-Nolte
T cells of different developmental stages differ in sensitivity to apoptosis induced by extracellular NAD.
Developmental immunology 2002;9(4):197-202.
2002: Wiebke Ohlrogge; Friedrich Haag; Jürgen Löhler; Michel Seman; Dan R Littman; Nigel Killeen; Friedrich Koch-Nolte
Generation and characterization of ecto-ADP-ribosyltransferase ART2.1/ART2.2-deficient mice.
Molecular and cellular biology 2002;22(21):7535-42.
2002: Sahil Adriouch; Claudia Dox; Vivienne Welge; Michel Seman; Friedrich Koch-Nolte; Friedrich Haag
Cutting edge: a natural P451L mutation in the cytoplasmic domain impairs the function of the mouse P2X7 receptor.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(8):4108-12.
2002: Christoph Mueller-Dieckmann; Holger Ritter; Friedrich Haag; Friedrich Koch-Nolte; Georg E Schulz
Structure of the ecto-ADP-ribosyl transferase ART2.2 from rat.
Journal of molecular biology 2002;322(4):687-96.
2002: Stefan Rothenburg; Maike Eiben; Friedrich Koch-Nolte; Friedrich Haag
Independent integration of rodent identifier (ID) elements into orthologous sites of some RT6 alleles of Rattus norvegicus and Rattus rattus.
Journal of molecular evolution 2002;55(3):251-9.
2002: Christoph Mueller-Dieckmann; Till Scheuermann; Karsten Wursthorn; Jens Schröder; Friedrich Haag; Georg E Schulz; Friedrich Koch-Nolte
Expression, purification, crystallization and preliminary X-ray analysis of rat ecto-ADP-ribosyltransferase 2 (ART2.2).
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 7):1211-3.
2002: Gustavo Glowacki; Rickmer Braren; Kathrin Firner; Marion Nissen; Maren Kühl; Pedro A Reche; J. Fernando Bazan; Marina Cetkovic-Cvrlje; Edward H Leiter; Friedrich Haag; Friedrich Koch-Nolte
The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse.
Protein science : a publication of the Protein Society 2002;11(7):1657-70.
2002: Andreas Grahnert; Maik Friedrich; Martin Pfister; Friedrich Haag; Friedrich Koch-Nolte; Sunna Hauschildt
Mono-ADP-ribosyltransferases in human monocytes: regulation by lipopolysaccharide.
The Biochemical journal 2002;362(Pt 3):717-23.
2002: Stefan Rothenburg; Thomas Schwartz; Friedrich Koch-Nolte; Friedrich Haag
Complex regulation of the human gene for the Z-DNA binding protein DLM-1.
Nucleic acids research 2002;30(4):993-1000.
2001: Stefan Rothenburg; Friedrich Koch-Nolte; Friedrich Haag
DNA methylation and Z-DNA formation as mediators of quantitative differences in the expression of alleles.
Immunological reviews 2001;184():286-98.
2001: Gustavo Glowacki; Rickmer Braren; Marina Cetkovic-Cvrlje; Edward H Leiter; Friedrich Haag; Friedrich Koch-Nolte
Structure, chromosomal localization, and expression of the gene for mouse ecto-mono(ADP-ribosyl)transferase ART5.
Gene 2001;275(2):267-77.
2001: Stefan Rothenburg; Friedrich Koch-Nolte; A Rich; Friedrich Haag
A polymorphic dinucleotide repeat in the rat nucleolin gene forms Z-DNA and inhibits promoter activity.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(16):8985-90.
2001: Vitaly Ablamunits; MM Bridgett; T Duffy; Friedrich Haag; Marion Nissen; Friedrich Koch-Nolte; H Leiter
Changing patterns of cell surface mono (ADP-ribosyl) transferase antigen ART2.2 on resting versus cytopathically-activated T cells in NOD/Lt mice.
Diabetologia 2001;44(7):848-58.
2001: Sahil Adriouch; Wiebke Ohlrogge; Friedrich Haag; Friedrich Koch-Nolte; Michel Seman
Rapid induction of naive T cell apoptosis by ecto-nicotinamide adenine dinucleotide: requirement for mono(ADP-ribosyl)transferase 2 and a downstream effector.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(1):196-203.
2001: Dilek Tezcan-Merdol; T Nyman; Uno Lindberg; Friedrich Haag; Friedrich Koch-Nolte; Mikael Rhen
Actin is ADP-ribosylated by the Salmonella enterica virulence-associated protein SpvB.
Molecular microbiology 2001;39(3):606-19.
2001: Stefan Rothenburg; Friedrich Koch-Nolte; HG Thiele; Friedrich Haag
DNA methylation contributes to tissue- and allele-specific expression of the T-cell differentiation marker RT6.
Immunogenetics 2001;52(3-4):231-41.
2000: S Kahl; Marion Nissen; R Girisch; T Duffy; Edward H Leiter; Friedrich Haag; Friedrich Koch-Nolte
Metalloprotease-mediated shedding of enzymatically active mouse ecto-ADP-ribosyltransferase ART2.2 upon T cell activation.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(8):4463-9.
2000: H Otto; Dilek Tezcan-Merdol; R Girisch; Friedrich Haag; Mikael Rhen; Friedrich Koch-Nolte
The spvB gene-product of the Salmonella enterica virulence plasmid is a mono(ADP-ribosyl)transferase.
Molecular microbiology 2000;37(5):1106-15.
1999: Friedrich Koch-Nolte; T Duffy; Marion Nissen; S Kahl; N Killeen; Vitaly Ablamunits; Friedrich Haag; Edward H Leiter
A new monoclonal antibody detects a developmentally regulated mouse ecto-ADP-ribosyltransferase on T cells: subset distribution, inbred strain variation, and modulation upon T cell activation.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(11):6014-22.
1999: J Fang; Stefan Rothenburg; Friedrich Koch-Nolte; HG Thiele; Friedrich Haag
Mutation of a putative TATA motif does not affect transcription by the promoter of the rat T cell differentiation marker RT6.
Transplantation proceedings 1999;31(3):1629-30.
1999: Stefan Rothenburg; Friedrich Koch-Nolte; HG Thiele; Friedrich Haag
Evidence that allelic variations in the main RT6 promoter modulate transcriptional activity.
Transplantation proceedings 1999;31(3):1626-8.
1999: Stefan Rothenburg; Friedrich Koch-Nolte; HG Thiele; Friedrich Haag
Expression of the T-cell differentiation antigen RT6.2 in T-cell lines is correlated with hypomethylation of the RT6 promoter.
Transplantation proceedings 1999;31(3):1624-5.
1998: Rickmer Braren; Gustavo Glowacki; Marion Nissen; Friedrich Haag; Friedrich Koch-Nolte
Molecular characterization and expression of the gene for mouse NAD+:arginine ecto-mono(ADP-ribosyl)transferase, Art1.
The Biochemical journal 1998;336 ( Pt 3)():561-8.
1998: Friedrich Haag; Friedrich Koch-Nolte
Endogenous relatives of ADP-ribosylating bacterial toxins in mice and men: potential regulators of immune cell function.
Journal of biological regulators and homeostatic agents 1998;12(3):53-62.
1997: Friedrich Haag; Stefan Rothenburg; Friedrich Koch-Nolte; HG Thiele
Polymorphic microsatellite within the main promoter of the rat T cell differentiation antigen RT6 on chromosome 1.
Transplantation proceedings 1997;29(3):1703-4.
1997: G Kuhlenbäumer; Friedrich Haag; Friedrich Koch-Nolte; H G Thiele
Transcription of the gene for the rat T cell differentiation marker RT6 is mainly mediated by a promoter 5' of exon 2.
Transplantation proceedings 1997;29(3):1701-2.
1997: Friedrich Haag; Friedrich Koch-Nolte; A Gerber; J Schröder; HG Thiele
Rat T cell differentiation alloantigens RT6.1 and RT6.2 are NAD(+)-metabolizing ecto-enzymes that differ in their enzymatic activities.
Transplantation proceedings 1997;29(3):1699-700.
1997: Friedrich Koch-Nolte; Friedrich Haag; Rickmer Braren; Maren Kühl; J Hoovers; Sriram Balasubramanian; J. Fernando Bazan; HG Thiele
Two novel human members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxins.
Genomics 1997;39(3):370-6.
1997: Friedrich Haag; Friedrich Koch-Nolte
The vertebrate gene family of mono(ADP-ribosyl)transferases. Proposal for a unified nomenclature.
Advances in experimental medicine and biology 1997;419():459-62.
1997: M Matthes; C Hollmann; H Bertuleit; Maren Kühl; HG Thiele; Friedrich Haag; Friedrich Koch-Nolte
"Natural" RT6-1 and RT6-2 "knock-out" mice.
Advances in experimental medicine and biology 1997;419():271-4.
1997: G Kuhlenbäumer; Stefan Rothenburg; M Matthes; C Hollmann; Edgar Wingender; HG Thiele; Friedrich Koch-Nolte; Friedrich Haag
Expression of the RT6 mono(ADP-ribosyl)transferases is regulated by two promoter regions.
Advances in experimental medicine and biology 1997;419():265-70.
1997: K Bredehorst; Karsten Wursthorn; HG Thiele; Friedrich Haag; Friedrich Koch-Nolte
Using secondary structure predictions and site-directed mutagenesis to identify and probe the role of potential active site motifs in the RT6 mono(ADP-ribosyl)transferases.
Advances in experimental medicine and biology 1997;419():185-9.
1997: Rickmer Braren; K Firner; Sriram Balasubramanian; J. Fernando Bazan; HG Thiele; Friedrich Haag; Friedrich Koch-Nolte
Use of the EST database resource to identify and clone novel mono(ADP-ribosyl)transferase gene family members.
Advances in experimental medicine and biology 1997;419():163-8.
1997: HG Thiele; Friedrich Haag; Friedrich Koch-Nolte
Molecular cloning and characterization of the T-cell mono(ADP-ribosyl)transferase RT6. Relationships to other mADPRTs and possible functions.
Advances in experimental medicine and biology 1997;419():109-20.
1997: Friedrich Koch-Nolte; Friedrich Haag
Mono(ADP-ribosyl)transferases and related enzymes in animal tissues. Emerging gene families.
Advances in experimental medicine and biology 1997;419():1-13.
1996: Friedrich Koch-Nolte; Friedrich Haag; R Kastelein; J. Fernando Bazan
Uncovered: the family relationship of a T-cell-membrane protein and bacterial toxins.
Immunology today 1996;17(9):402-5.
1996: Friedrich Haag; G Kuhlenbäumer; Friedrich Koch-Nolte; Edgar Wingender; HG Thiele
Structure of the gene encoding the rat T cell ecto-ADP-ribosyltransferase RT6.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(5):2022-30.
1996: Friedrich Koch-Nolte; M Kühl; Friedrich Haag; M Cetkovic-Cvrlje; E H Leiter; HG Thiele
Assignment of the human and mouse genes for muscle ecto mono (ADPribosyl)transferase to a conserved linkage group on human chromosome 11p15 and mouse chromosome 7.
Genomics 1996;36(1):215-6.
1996: C Hollmann; Friedrich Haag; M Schlott; A Damaske; H Bertuleit; M Matthes; M Kühl; HG Thiele; Friedrich Koch-Nolte
Molecular characterization of mouse T-cell ecto-ADP-ribosyltransferase Rt6: cloning of a second functional gene and identification of the Rt6 gene products.
Molecular immunology 1996;33(9):807-17.
1996: Friedrich Koch-Nolte; D Petersen; Sriram Balasubramanian; Friedrich Haag; D Kahlke; T Willer; R Kastelein; J. Fernando Bazan; HG Thiele
Mouse T cell membrane proteins Rt6-1 and Rt6-2 are arginine/protein mono(ADPribosyl)transferases and share secondary structure motifs with ADP-ribosylating bacterial toxins.
The Journal of biological chemistry 1996;271(13):7686-93.
1995: Friedrich Haag; V Andresen; S Karsten; Friedrich Koch-Nolte; H Thiele
Both allelic forms of the rat T cell differentiation marker RT6 display nicotinamide adenine dinucleotide (NAD)-glycohydrolase activity, yet only RT6.2 is capable of automodification upon incubation with NAD.
European journal of immunology 1995;25(8):2355-61.
1995: Friedrich Koch-Nolte; J Klein; C Hollmann; M Kühl; Friedrich Haag; H. Rex Gaskins; E Leiter; HG Thiele
Defects in the structure and expression of the genes for the T cell marker Rt6 in NZW and (NZB x NZW)F1 mice.
International immunology 1995;7(5):883-90.
1995: Friedrich Koch-Nolte; C Hollmann; M Kühl; Friedrich Haag; M Prochazka; E Leiter; HG Thiele
Molecular polymorphism in the Rt6 genes of laboratory mice correlates with the allotypes of the H1 minor histocompatibility system.
Immunogenetics 1995;41(2-3):152-5.
1994: Friedrich Haag; Friedrich Koch-Nolte; M Kühl; S Lorenzen; HG Thiele
Premature stop codons inactivate the RT6 genes of the human and chimpanzee species.
Journal of molecular biology 1994;243(3):537-46.
1994: Friedrich Koch-Nolte; S Singh; Friedrich Haag; M Kühl; HG Thiele
BglII identifies a frequent biallelic DNA polymorphism of the human RT6 gene.
Human genetics 1994;93(6):724.
1994: P Sarkar; L Crisá; U McKeever; Rita Bortell; E Handler; John P Mordes; D Waite; A Schoenbaum; Friedrich Haag; Friedrich Koch-Nolte
Loss of RT6 message and most circulating T cells after thymectomy of diabetes prone BB rats.
Autoimmunity 1994;18(1):15-22.
1993: Friedrich Koch-Nolte; Friedrich Haag; M Kühl; Veronica van Heyningen; J Hoovers; K H Grzeschik; S Singh; HG Thiele
Assignment of the human RT6 gene to 11q13 by PCR screening of somatic cell hybrids and in situ hybridization.
Genomics 1993;18(2):404-6.
1991: M Prochazka; H. Rex Gaskins; Edward H Leiter; Friedrich Koch-Nolte; Friedrich Haag; HG Thiele
Chromosomal localization, DNA polymorphism, and expression of Rt-6, the mouse homologue of rat T-lymphocyte differentiation marker RT6.
Immunogenetics 1991;33(2):152-6.