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Gregory Adams

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Siddharth Balachandran; Gregory P Adams
Interferon-γ-induced necrosis: an antitumor biotherapeutic perspective.
Jiping Zhang; Gregory P Adams; Hyung-Ok Lee; Wayne A Marasco; Stefanie R Mullins; Matthew K Robinson; Heidi Simmons; Matthildi Valianou; Louis M Weiner; Jonathan D Cheng
Identification of inhibitory scFv antibodies targeting fibroblast activation protein utilizing phage display functional screens.
Peirong Chen; Shoko Nogusa; Suraj Peri; Calvin Shaller; Heidi Simmons; Roshan J Thapa; Gregory P Adams; Siddharth Balachandran
Anti-CD70 Immunocytokines for Exploitation of Interferon-γ-Induced RIP1-Dependent Necrosis in Renal Cell Carcinoma.

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2013: Siddharth Balachandran; Gregory P Adams
Interferon-γ-induced necrosis: an antitumor biotherapeutic perspective.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2013;33(4):171-80.
2013: Jiping Zhang; Gregory P Adams; Hyung-Ok Lee; Wayne A Marasco; Stefanie R Mullins; Matthew K Robinson; Heidi Simmons; Matthildi Valianou; Louis M Weiner; Jonathan D Cheng
Identification of inhibitory scFv antibodies targeting fibroblast activation protein utilizing phage display functional screens.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013;27(2):581-9.
2013: Peirong Chen; Shoko Nogusa; Suraj Peri; Calvin Shaller; Heidi Simmons; Roshan J Thapa; Gregory P Adams; Siddharth Balachandran
Anti-CD70 Immunocytokines for Exploitation of Interferon-γ-Induced RIP1-Dependent Necrosis in Renal Cell Carcinoma.
PloS one 2013;8(4):e61446.
2011: LiNa Loo; Joseph A Capobianco; Wei Wu; Xiaotong Gao; Wan Y Shih; Wei-Heng Shih; Kambiz Pourrezaei; Matthew K Robinson; Gregory P Adams
Highly sensitive detection of HER2 extracellular domain in the serum of breast cancer patients by piezoelectric microcantilevers.
Analytical chemistry 2011;83(9):3392-7.
2011: LiNa Loo; Kambiz Pourrezaei; Wei-Heng Shih; Wan Y Shih; Wei Wu; Hossein Borghaei; Gregory P Adams
A rapid method to regenerate piezoelectric microcantilever sensors (PEMS).
Sensors (Basel, Switzerland) 2011;11(5):5520-8.
2009: Stephen I Rudnick; Gregory P Adams
Affinity and avidity in antibody-based tumor targeting.
Cancer biotherapy & radiopharmaceuticals 2009;24(2):155-61.
2009: Lily Yang; Hui Mao; Y Andrew Wang; Zehong Cao; Xianghong Peng; Xiaoxia Wang; Hongwei Duan; Chunchun Ni; Qingan Yuan; Gregory P Adams; Mark Q Smith; William C Wood; Xiaohu Gao; Shuming Nie
Single chain epidermal growth factor receptor antibody conjugated nanoparticles for in vivo tumor targeting and imaging.
Small (Weinheim an der Bergstrasse, Germany) 2009;5(2):235-43.
2008: Matthew K Robinson; K M Hodge; Eva M Horak; A L Sundberg; Maria Russeva; Calvin Shaller; Margaret von Mehren; Irina Shchaveleva; Heidi H Simmons; James D Marks; Gregory P Adams
Targeting ErbB2 and ErbB3 with a bispecific single-chain Fv enhances targeting selectivity and induces a therapeutic effect in vitro.
British journal of cancer 2008;99(9):1415-25.
2008: Jianhua Sui; Daniel R Aird; Azaibi Tamin; Akikazu Murakami; Meiying Yan; Anuradha Yammanuru; Huaiqi Jing; Biao Kan; Xin Liu; Quan Zhu; Qing-An Yuan; Gregory P Adams; William Joseph Bellini; Jianguo Xu; Larry J Anderson; Wayne A Marasco
Broadening of neutralization activity to directly block a dominant antibody-driven SARS-coronavirus evolution pathway.
PLoS pathogens 2008;4(11):e1000197.
2008: Joseph A Capobianco; Wan Y Shih; Qing-An Yuan; Gregory P Adams; Wei-Heng Shih
Label-free, all-electrical, in situ human epidermal growth receptor 2 detection.
The Review of scientific instruments 2008;79(7):076101.
2008: LiNa Loo; Matthew K Robinson; Gregory P Adams
Antibody engineering principles and applications.
Cancer journal (Sudbury, Mass.) 2008;14(3):149-53.
2008: Qing-An Yuan; Matthew K Robinson; Heidi H Simmons; Maria Russeva; Gregory P Adams
Isolation of anti-MISIIR scFv molecules from a phage display library by cell sorter biopanning.
Cancer immunology, immunotherapy : CII 2008;57(3):367-78.
2008: Matthew K Robinson; Calvin Shaller; Kayhan Garmestani; Paul S Plascjak; Kathryn M Hodge; Qing-An Yuan; James D Marks; Thomas Waldmann; Martin W Brechbiel; Gregory P Adams
Effective treatment of established human breast tumor xenografts in immunodeficient mice with a single dose of the alpha-emitting radioisotope astatine-211 conjugated to anti-HER2/neu diabodies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(3):875-82.
2007: Yu Zhou; Daryl C Drummond; Hao Zou; Mark E Hayes; Gregory P Adams; Dmitri B Kirpotin; James D Marks
Impact of single-chain Fv antibody fragment affinity on nanoparticle targeting of epidermal growth factor receptor-expressing tumor cells.
Journal of molecular biology 2007;371(4):934-47.
2007: Erika Nordberg; Mikaela Friedman; Lovisa Göstring; Gregory P Adams; hjalmar brismar; Fredrik Y Nilsson; Stefan Ståhl; Bengt Glimelius; Jörgen Carlsson
Cellular studies of binding, internalization and retention of a radiolabeled EGFR-binding affibody molecule.
Nuclear medicine and biology 2007;34(6):609-18.
2007: M Friedman; Erika Nordberg; Ingmarie Höidén Guthenberg; hjalmar brismar; Gregory P Adams; Fredrik Y Nilsson; J Carlsson; Stefan Ståhl
Phage display selection of Affibody molecules with specific binding to the extracellular domain of the epidermal growth factor receptor.
Protein engineering, design & selection : PEDS 2007;20(4):189-99.
2006: Qing-An Yuan; Heidi H Simmons; Matthew K Robinson; Maria Russeva; Wayne A Marasco; Gregory P Adams
Development of engineered antibodies specific for the Müllerian inhibiting substance type II receptor: a promising candidate for targeted therapy of ovarian cancer.
Molecular cancer therapeutics 2006;5(8):2096-105.
2006: Ann-Charlott Steffen; Anna Orlova; Maria Wikman; Fredrik Y Nilsson; Stefan Ståhl; Gregory P Adams; Vladimir Tolmachev; Jörgen Carlsson
Affibody-mediated tumour targeting of HER-2 expressing xenografts in mice.
European journal of nuclear medicine and molecular imaging 2006;33(6):631-8.
2006: Gregory P Adams; Mei-Sheng Tai; John E McCartney; James D Marks; Walter F Stafford; L L Houston; James S Huston; Louis M Weiner
Avidity-mediated enhancement of in vivo tumor targeting by single-chain Fv dimers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(5):1599-605.
2005: Eva M Horak; Tara Heitner; Matthew K Robinson; Heidi H Simmons; Jennifer Garrison; Maria Russeva; Polina Furmanova; Jianlong Lou; Yu Zhou; Qing-An Yuan; Louis M Weiner; Gregory P Adams; James D Marks
Isolation of scFvs to in vitro produced extracellular domains of EGFR family members.
Cancer biotherapy & radiopharmaceuticals 2005;20(6):603-13.
2005: Gregory P Adams; Louis M Weiner
Monoclonal antibody therapy of cancer.
Nature biotechnology 2005;23(9):1147-57.
2005: Ann-Charlott Steffen; Maria Wikman; Vladimir Tolmachev; Gregory P Adams; Fredrik Y Nilsson; Stefan Ståhl; Jörgen Carlsson
In vitro characterization of a bivalent anti-HER-2 affibody with potential for radionuclide-based diagnostics.
Cancer biotherapy & radiopharmaceuticals 2005;20(3):239-48.
2005: Matthew K Robinson; Mohan Doss; Calvin Shaller; Deepa Narayanan; James D Marks; Lee P Adler; Dinko E González Trotter; Gregory P Adams
Quantitative immuno-positron emission tomography imaging of HER2-positive tumor xenografts with an iodine-124 labeled anti-HER2 diabody.
Cancer research 2005;65(4):1471-8.
2004: Markus Chmielewski; Andreas Hombach; Claudia Heuser; Gregory P Adams; Hinrich Abken
T cell activation by antibody-like immunoreceptors: increase in affinity of the single-chain fragment domain above threshold does not increase T cell activation against antigen-positive target cells but decreases selectivity.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(12):7647-53.
2004: Gregory P Adams; Calvin Shaller; Ekaterina Dadachova; Heidi H Simmons; Eva M Horak; Abohawariat Tesfaye; Andres J P Klein-Szanto; James D Marks; Martin W Brechbiel; Louis M Weiner
A single treatment of yttrium-90-labeled CHX-A"-C6.5 diabody inhibits the growth of established human tumor xenografts in immunodeficient mice.
Cancer research 2004;64(17):6200-6.
2004: Dinko E González Trotter; Ravindra M Manjeshwar; Mohan Doss; Calvin Shaller; Matthew K Robinson; Reeti Tandon; Gregory P Adams; Lee P Adler
Quantitation of small-animal (124)I activity distributions using a clinical PET/CT scanner.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2004;45(7):1237-44.
2004: Maria Wikman; A-C Steffen; Elin Gunneriusson; Vladimir Tolmachev; Gregory P Adams; J Carlsson; Stefan Ståhl
Selection and characterization of HER2/neu-binding affibody ligands.
Protein engineering, design & selection : PEDS 2004;17(5):455-62.
2004: Maria Russeva; Gregory P Adams
Radioimmunotherapy with engineered antibodies.
Expert opinion on biological therapy 2004;4(2):217-31.
2003: Margaret von Mehren; Gregory P Adams; Louis M Weiner
Monoclonal antibody therapy for cancer.
Annual review of medicine 2003;54():343-69.
2001: Gregory P Adams; R Schier; AM McCall; Heidi H Simmons; Eva M Horak; R Katherine Alpaugh; James D Marks; Louis M Weiner
High affinity restricts the localization and tumor penetration of single-chain fv antibody molecules.
Cancer research 2001;61(12):4750-5.
2001: AM McCall; L Shahied; AR Amoroso; Eva M Horak; Heidi H Simmons; U Nielson; Gregory P Adams; R Schier; James D Marks; Louis M Weiner
Increasing the affinity for tumor antigen enhances bispecific antibody cytotoxicity.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(10):6112-7.
2001: D B Powers; Peter Amersdorfer; Marie-Alix Poul; Ulrik B Nielsen; M R Shalaby; Gregory P Adams; Louis M Weiner; James D Marks
Expression of single-chain Fv-Fc fusions in Pichia pastoris.
Journal of immunological methods 2001;251(1-2):123-35.
2001: Gregory P Adams; L M Weiner
Radioimmunotherapy of solid tumors: from fairytale to reality.
Cancer biotherapy & radiopharmaceuticals 2001;16(1):9-11.
2001: Gregory P Adams; R Schier
Developing Anti-HER2/neu Single-Chain Fv Fragments from Phage Display Libraries.
Methods in molecular medicine 2001;39():729-47.
2000: Louis M Weiner; Gregory P Adams
New approaches to antibody therapy.
Oncogene 2000;19(53):6144-51.
2000: Ulrik B Nielsen; Gregory P Adams; Louis M Weiner; James D Marks
Targeting of bivalent anti-ErbB2 diabody antibody fragments to tumor cells is independent of the intrinsic antibody affinity.
Cancer research 2000;60(22):6434-40.
2000: J D Cheng; P T Rieger; Margaret von Mehren; Gregory P Adams; Louis M Weiner
Recent advances in immunotherapy and monoclonal antibody treatment of cancer.
Seminars in oncology nursing 2000;16(4 Suppl 1):2-12.
2000: Gregory P Adams; Calvin Shaller; L L Chappell; Carl Wu; Eva M Horak; Heidi H Simmons; S Litwin; James D Marks; Louis M Weiner; Martin W Brechbiel
Delivery of the alpha-emitting radioisotope bismuth-213 to solid tumors via single-chain Fv and diabody molecules.
Nuclear medicine and biology 2000;27(4):339-46.
2000: Susan J Knox; Michael L Goris; Margaret A Tempero; Paul L Weiden; L Gentner; Hazel Breitz; Gregory P Adams; Axworthy Don; S Gaffigan; K Bryan; Darrell R Fisher; David Colcher; I D Horak; Louis M Weiner
Phase II trial of yttrium-90-DOTA-biotin pretargeted by NR-LU-10 antibody/streptavidin in patients with metastatic colon cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(2):406-14.
1999: Gregory P Adams; R Schier
Generating improved single-chain Fv molecules for tumor targeting.
Journal of immunological methods 1999;231(1-2):249-60.
1999: AM McCall; Gregory P Adams; AR Amoroso; Ulrik B Nielsen; L Zhang; Eva M Horak; Heidi H Simmons; R Schier; James D Marks; Louis M Weiner
Isolation and characterization of an anti-CD16 single-chain Fv fragment and construction of an anti-HER2/neu/anti-CD16 bispecific scFv that triggers CD16-dependent tumor cytolysis.
Molecular immunology 1999;36(7):433-45.
1998: Gregory P Adams; R Schier; AM McCall; Robert Crawford; E J Wolf; Louis M Weiner; James D Marks
Prolonged in vivo tumour retention of a human diabody targeting the extracellular domain of human HER2/neu.
British journal of cancer 1998;77(9):1405-12.
1998: Gregory P Adams; R Schier; K Marshall; E J Wolf; AM McCall; James D Marks; Louis M Weiner
Increased affinity leads to improved selective tumor delivery of single-chain Fv antibodies.
Cancer research 1998;58(3):485-90.
1998: Gregory P Adams
Improving the tumor specificity and retention of antibody-based molecules.
In vivo (Athens, Greece) 1998;12(1):11-21.
1996: R Schier; AM McCall; Gregory P Adams; K W Marshall; H Merritt; M Yim; Robert Crawford; Louis M Weiner; C Marks; James D Marks
Isolation of picomolar affinity anti-c-erbB-2 single-chain Fv by molecular evolution of the complementarity determining regions in the center of the antibody binding site.
Journal of molecular biology 1996;263(4):551-67.
1996: J S Huston; Andrew J T George; Gregory P Adams; W F Stafford; François Jamar; M S Tai; J E McCartney; H Oppermann; B T Heelan; A Michael Peters; L L Houston; M A Bookman; E J Wolf; Louis M Weiner
Single-chain Fv radioimmunotargeting.
The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR) 1996;40(3):320-33.
1996: Louis M Weiner; R Katherine Alpaugh; AR Amoroso; Gregory P Adams; D B Ring; M W Barth
Human neutrophil interactions of a bispecific monoclonal antibody targeting tumor and human Fc gamma RIII.
Cancer immunology, immunotherapy : CII 1996;42(3):141-50.
1996: R Schier; J Bye; G Apell; AM McCall; Gregory P Adams; M Malmqvist; Louis M Weiner; James D Marks
Isolation of high-affinity monomeric human anti-c-erbB-2 single chain Fv using affinity-driven selection.
Journal of molecular biology 1996;255(1):28-43.
1996: AR Amoroso; J I Clark; Samuel Litwin; S Hsieh-Ma; T Shi; R Katherine Alpaugh; Gregory P Adams; E J Wolf; D B Ring; Louis M Weiner
Binding characteristics and antitumor properties of 1A10 bispecific antibody recognizing gp40 and human transferrin receptor.
Cancer research 1996;56(1):113-20.
1995: Gregory P Adams; J E McCartney; E J Wolf; J Eisenberg; J S Huston; M A Bookman; P Moldofsky; W F Stafford; L L Houston; Louis M Weiner
Enhanced tumor specificity of 741F8-1 (sFv')2, an anti-c-erbB-2 single-chain Fv dimer, mediated by stable radioiodine conjugation.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1995;36(12):2276-81.
1995: M S Tai; J E McCartney; Gregory P Adams; D Jin; R M Hudziak; H Oppermann; A A Laminet; M A Bookman; E J Wolf; S Liu
Targeting c-erbB-2 expressing tumors using single-chain Fv monomers and dimers.
Cancer research 1995;55(23 Suppl):5983s-5989s.
1995: Gregory P Adams; L M Weiner
Intracellular single-chain Fv antibodies--a knockout punch for neoplastic cells?
Gynecologic oncology 1995;59(1):6-7.
1995: Andrew J T George; François Jamar; M S Tai; B T Heelan; Gregory P Adams; J E McCartney; L L Houston; Louis M Weiner; H Oppermann; A Michael Peters
Radiometal labeling of recombinant proteins by a genetically engineered minimal chelation site: technetium-99m coordination by single-chain Fv antibody fusion proteins through a C-terminal cysteinyl peptide.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(18):8358-62.
1995: Gregory P Adams; J E McCartney; E J Wolf; J Eisenberg; M S Tai; J S Huston; W F Stafford; M A Bookman; L L Houston; Louis M Weiner
Optimization of in vivo tumor targeting in SCID mice with divalent forms of 741F8 anti-c-erbB-2 single-chain Fv: effects of dose escalation and repeated i.v. administration.
Cancer immunology, immunotherapy : CII 1995;40(5):299-306.
1995: J E McCartney; M S Tai; R M Hudziak; Gregory P Adams; Louis M Weiner; D Jin; W F Stafford; S Liu; M A Bookman; A A Laminet
Engineering disulfide-linked single-chain Fv dimers [(sFv')2] with improved solution and targeting properties: anti-digoxin 26-10 (sFv')2 and anti-c-erbB-2 741F8 (sFv')2 made by protein folding and bonded through C-terminal cysteinyl peptides.
Protein engineering 1995;8(3):301-14.
1994: J S Huston; Gregory P Adams; J E McCartney; M S Tai; R M Hudziak; H Oppermann; W F Stafford; S Liu; I Fand; G Apell
Tumor targeting in a murine tumor xenograft model with the (sFv')2 divalent form of anti-c-erbB-2 single-chain Fv.
Cell biophysics 1994;24-25():267-78.
1993: Louis M Weiner; M Holmes; A Richeson; A Godwin; Gregory P Adams; S T Hsieh-Ma; D B Ring; R Katherine Alpaugh
Binding and cytotoxicity characteristics of the bispecific murine monoclonal antibody 2B1.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(5):2877-86.
1993: Gregory P Adams; J E McCartney; M S Tai; H Oppermann; J S Huston; W F Stafford; M A Bookman; I Fand; L L Houston; Louis M Weiner
Highly specific in vivo tumor targeting by monovalent and divalent forms of 741F8 anti-c-erbB-2 single-chain Fv.
Cancer research 1993;53(17):4026-34.
1993: I E Garcia de Palazzo; Gregory P Adams; P Sundareshan; Albert J Wong; Joseph R Testa; D D Bigner; Louis M Weiner
Expression of mutated epidermal growth factor receptor by non-small cell lung carcinomas.
Cancer research 1993;53(14):3217-20.
1993: Louis M Weiner; M Holmes; Gregory P Adams; F LaCreta; P Watts; I Garcia de Palazzo
A human tumor xenograft model of therapy with a bispecific monoclonal antibody targeting c-erbB-2 and CD16.
Cancer research 1993;53(1):94-100.