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Walter Koch

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Philip Raake; Julia Reinkober; Stefanie Schinkel; Philipp Schlegel; Sven T Pleger; Jens Barthelmes; Uwe Haberkorn; Hugo A Katus; Walter J Koch; Jan Ksienzyk; Walter Mier; Patrick Most; Oliver J Müller
AAV6.βARKct cardiac gene therapy ameliorates cardiac function and normalizes the catecholaminergic axis in a clinically relevant large animal heart failure model.
Mai Chen; J Kurt Chuprun; Erhe Gao; Jessica Ibetti; Nicholas J Otis; Shi Pan; Raymond J Peroutka; Priscila Y Sato; Shey-Shing Sheu; Walter J Koch
Prodeath signaling of g protein-coupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targeting.
JaBaris D Swain; Catherine E Tomasulo; Anthony S Fargnoli; Michael G Katz; Walter J Koch; Joseph E Rabinowitz; Kyle C Richardville; Marina Sumaroka; Charles R Bridges
MCARD-mediated gene transfer of GRK2 inhibitor in ovine model of acute myocardial infarction.

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2013: Philip Raake; Julia Reinkober; Stefanie Schinkel; Philipp Schlegel; Sven T Pleger; Jens Barthelmes; Uwe Haberkorn; Hugo A Katus; Walter J Koch; Jan Ksienzyk; Walter Mier; Patrick Most; Oliver J Müller
AAV6.βARKct cardiac gene therapy ameliorates cardiac function and normalizes the catecholaminergic axis in a clinically relevant large animal heart failure model.
European heart journal 2013;34(19):1437-47.
2013: Mai Chen; J Kurt Chuprun; Erhe Gao; Jessica Ibetti; Nicholas J Otis; Shi Pan; Raymond J Peroutka; Priscila Y Sato; Shey-Shing Sheu; Walter J Koch
Prodeath signaling of g protein-coupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targeting.
Circulation research 2013;112(8):1121-34.
2013: JaBaris D Swain; Catherine E Tomasulo; Anthony S Fargnoli; Michael G Katz; Walter J Koch; Joseph E Rabinowitz; Kyle C Richardville; Marina Sumaroka; Charles R Bridges
MCARD-mediated gene transfer of GRK2 inhibitor in ovine model of acute myocardial infarction.
Journal of cardiovascular translational research 2013;6(2):253-62.
2013: Wayne Bond Lau; Baojiang Liu; Bernard Lopez; Xin L Ma; Xiaoliang Wang; Theodore A Christopher; Erhe Gao; Walter J Koch; Yuexing Yuan; Yanqing Zhang; Jianli Zhao; Yajing Wang
Lymphotoxin-α is a novel adiponectin expression suppressor following myocardial ischemia/reperfusion.
American journal of physiology. Endocrinology and metabolism 2013;304(6):E661-7.
2013: Patrick Most; Sven T Pleger; Giuseppe Rengo; Julia Ritterhoff; David Rohde; Norbert Weiss; Cornelius J Busch; Chelain Goodman; Julian Heissenberg; Hugo A Katus; Walter J Koch; Felix Laube; Carolin Lerchenmüller; Adrian Mahlmann; Karsten Peppel
S100A1 deficiency impairs postischemic angiogenesis via compromised proangiogenic endothelial cell function and nitric oxide synthase regulation.
Circulation research 2013;112(1):66-78.
2013: Jessica I Gold; Jonathan Hullmann; Donald M Bers; Julie Bossuyt; J Kurt Chuprun; Erhe Gao; Linda Lee; Jeffrey S Martini; Joseph E Rabinowitz; Douglas G Tilley; Walter J Koch
Nuclear translocation of cardiac G protein-Coupled Receptor kinase 5 downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process.
PloS one 2013;8(3):e57324.
2013: Hui Su; Xiaoliang Wang; Xiao-Ming Wang; Yajing Wang; Yuexing Yuan; Erhe Gao; Walter J Koch; Wayne Bond Lau; Xin-Liang Ma
Inhibition of CTRP9, a novel and cardiac-abundantly expressed cell survival molecule, by TNFα-initiated oxidative signaling contributes to exacerbated cardiac injury in diabetic mice.
Basic research in cardiology 2013;108(1):315.
2012: Elena Deliu; Walter J Koch; Muniswamy Madesh; Karthik Mallilankaraman; Ashiwel S Undieh; Hong Wang; G Cristina Brailoiu; Eugen Brailoiu
Intracellular endothelin type B receptor-driven Ca2+ signal elicits nitric oxide production in endothelial cells.
The Journal of biological chemistry 2012;287(49):41023-31.
2012: David M Thal; Emily K Wu; Jun Chen; Joseph Y Cheung; J Kurt Chuprun; Erhe Gao; Patricia M Hinkle; Kristoff T Homan; Z Maggie Huang; Walter J Koch; Larry A Sklar; Jianliang Song; John J G Tesmer
Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility.
ACS chemical biology 2012;7(11):1830-9.
2012: Yi Liu; Xiaoyan Lu; Yanzhuo Ma; Yan Qu; Lu Sun; Chao Gao; Erhe Gao; Walter J Koch; Wayne B Lau; Kun Lian; Jingyi Liu; Haichang Wang; Rutao Wang; Chenhai Xia; Aibing Xu; Lu Yang; Ling Tao
The alternative crosstalk between RAGE and nitrative thioredoxin inactivation during diabetic myocardial ischemia-reperfusion injury.
American journal of physiology. Endocrinology and metabolism 2012;303(7):E841-52.
2012: Jessica I Gold; Richard T Premont; Xiying Shang; Erhe Gao; Walter J Koch
Determining the absolute requirement of G protein-coupled receptor kinase 5 for pathological cardiac hypertrophy: short communication.
Circulation research 2012;111(8):1048-53.
2012: Nohra Chalouhi; Muhammad S Ali; L Fernando Gonzalez; Pascal M Jabbour; Walter J Koch; Robert H Rosenwasser; Stavropoula I Tjoumakaris; Aaron S Dumont
Biology of intracranial aneurysms: role of inflammation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2012;32(9):1659-76.
2012: Rachid Seqqat; Louis J Dell'Italia; Jianfen Guo; Xinji Guo; Steven R Houser; Walter J Koch; Mikhail A Kolpakov; Khadija Rafiq; Abdelkarim Sabri
Beta1-adrenergic receptors promote focal adhesion signaling downregulation and myocyte apoptosis in acute volume overload.
Journal of molecular and cellular cardiology 2012;53(2):240-9.
2012: Jean-Pierre Louboutin; Elena Marusich; Lokesh Agrawal; Ehre Gao; Walter J Koch; David S Strayer
Ethanol protects from injury due to ischemia and reperfusion by increasing vascularity via vascular endothelial growth factor.
Alcohol (Fayetteville, N.Y.) 2012;46(5):441-54.
2012: Giuseppe Rengo; Carmela Zincarelli; A Cannavo; C de Lucia; Gd Femminella; Nicola Ferrara; P Gargiulo; Walter J Koch; D Liccardo; Anastasios Lymperopoulos; G Pagano; P Perrone Filardi; Dario Leosco
Blockade of β-adrenoceptors restores the GRK2-mediated adrenal α(2) -adrenoceptor-catecholamine production axis in heart failure.
British journal of pharmacology 2012;166(8):2430-40.
2012: Giuseppe Rengo; D Ruggiero; Carmela Zincarelli; D Liccardo; Anastasios Lymperopoulos; G Pagano; Pasquale Perrone-Filardi; Giovanna Giuseppina Altobelli; Vincenzo Cimini; C de Lucia; G D Femminella; Nicola Ferrara; E Gao; Walter J Koch; Dario Leosco
Myocardial β(2) -adrenoceptor gene delivery promotes coordinated cardiac adaptive remodelling and angiogenesis in heart failure.
British journal of pharmacology 2012;166(8):2348-61.
2012: A Kathleen McClendon; Christopher A Reed; Dayana B Rivadeneira; Justine E Yu; Jeffry L Dean; John L Farber; Thomas Force; Erhe Gao; Walter J Koch; Erik S Knudsen
CDK4/6 inhibition antagonizes the cytotoxic response to anthracycline therapy.
Cell cycle (Georgetown, Tex.) 2012;11(14):2747-55.
2012: Wei Yi; Yuexing Yuan; Qijun Zheng; Erhe Gao; Walter J Koch; Wayne Bond Lau; Xiying Shang; Yang Sun; Xiaoliang Wang; Yajing Wang; Xin-Liang Ma
C1q/tumor necrosis factor-related protein-3, a newly identified adipokine, is a novel antiapoptotic, proangiogenic, and cardioprotective molecule in the ischemic mouse heart.
Circulation 2012;125(25):3159-69.
2012: Steven R Houser; David A Kass; Walter Koch; Walter J Koch; Kenneth B Margulies; Jeffery D Molkentin; Anne M Murphy; Sumanth D Prabhu; Howard A Rockman; Francis G Spinale; Mark A Sussman; Gary S Francis
Animal models of heart failure: a scientific statement from the American Heart Association.
Circulation research 2012;111(1):131-50.
2012: J Reinkober; H Tscheschner; Hugo A Katus; Walter J Koch; Patrick Most; Sven T Pleger; Philip Raake
Targeting GRK2 by gene therapy for heart failure: benefits above β-blockade.
Gene therapy 2012;19(6):686-93.
2012: Zhengyu Wei; Michele Ciccarelli; Reginald Hurtt; Walter J Koch; Cataldo Doria
Growth inhibition of human hepatocellular carcinoma cells by overexpression of G-protein-coupled receptor kinase 2.
Journal of cellular physiology 2012;227(6):2371-7.
2012: Philip Raake; Mingxin Tang; Leif Erik Vinge; Xiaoying Zhang; Yingxin Li; Patrick Most; Henriette Brinks; Xiongwen Chen; Gerald W Dorn; Erhe Gao; Steven R Houser; Naser Jaleel; Hugo A Katus; Walter J Koch
Cardiac G-protein-coupled receptor kinase 2 ablation induces a novel Ca2+ handling phenotype resistant to adverse alterations and remodeling after myocardial infarction.
Circulation 2012;125(17):2108-18.
2012: Kazi N Islam; Walter J Koch
Involvement of nuclear factor κB (NF-κB) signaling pathway in regulation of cardiac G protein-coupled receptor kinase 5 (GRK5) expression.
The Journal of biological chemistry 2012;287(16):12771-8.
2012: Yajing Wang; Wei Yi; Yuexin Yuan; Xiaoliang Wang; Kurt Chuprun; Erhe Gao; Jean-François Jasmin; Walter J Koch; Wayne Bond Lau; Rong Li; Michael P Lisanti; Xin-Liang Ma
Essential role of caveolin-3 in adiponectin signalsome formation and adiponectin cardioprotection.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(4):934-42.
2012: Hongyu Zhang; Remus M Berretta; Xiongwen Chen; Jason M Duran; Erhe Gao; Walter J Koch; Hajime Kubo; Ying Li; Catherine A Makarewich; Héctor H Valdivia; Wei Wang; Steven R Houser
Hyperphosphorylation of the cardiac ryanodine receptor at serine 2808 is not involved in cardiac dysfunction after myocardial infarction.
Circulation research 2012;110(6):831-40.
2012: Jianliang Song; Jufang Wang; Xue-Qian Zhang; Tung O Chan; Arthur M Feldman; Erhe Gao; Jeffrey I Joseph; Walter J Koch; Blaise Z Peterson; Xiying Shang; Joseph Y Cheung
Constitutive overexpression of phosphomimetic phospholemman S68E mutant results in arrhythmias, early mortality, and heart failure: potential involvement of Na+/Ca2+ exchanger.
American journal of physiology. Heart and circulatory physiology 2012;302(3):H770-81.
2012: Weizhong Zhu; Aizhi Zhao; Khalid Chakir; J Kurt Chuprun; Gerald W Dorn; Arthur M Feldman; Erhe Gao; Walter J Koch; Edward G Lakatta; Natalia Petrashevskaya; Shuxun Ren; Mark Talan; Yibin Wang; Rui-Ping Xiao
Gi-biased β2AR signaling links GRK2 upregulation to heart failure.
Circulation research 2012;110(2):265-74.
2012: Nohra Chalouhi; Muhammad S Ali; L Fernando Gonzalez; Pascal M Jabbour; Walter J Koch; Robert H Rosenwasser; Robert M Starke; Stavropoula I Tjoumakaris; Aaron S Dumont
Cigarette smoke and inflammation: role in cerebral aneurysm formation and rupture.
Mediators of inflammation 2012;2012():271582.
2012: Eman A Hamad; Walter J Koch; Xue Li; Valerie Myers; Jianliang Song; Jin Zhang; Xue-Qian Zhang; Weizhong Zhu; Tung O Chan; Joseph Y Cheung; Erhe Gao; Arthur M Feldman
Cardioprotection of controlled and cardiac-specific over-expression of A(2A)-adenosine receptor in the pressure overload.
PloS one 2012;7(7):e39919.
2012: Anastasios Lymperopoulos; Giuseppe Rengo; Walter J Koch
GRK2 inhibition in heart failure: something old, something new.
Current pharmaceutical design 2012;18(2):186-91.
2011: Hui Cheng; Walter J Koch; Adam P Dicker; Ulrich Rodeck; Gabor Kari; Thomas Force
A novel preclinical strategy for identifying cardiotoxic kinase inhibitors and mechanisms of cardiotoxicity.
Circulation research 2011;109(12):1401-9.
2011: Xue Li; Deana Mikhalkova; Valerie Myers; Karsten Peppel; Jianliang Song; Jin Zhang; Carmen Zincarelli; Joseph Y Cheung; Arthur M Feldman; Erhe Gao; Walter J Koch; Yonghong Lei; Tung O Chan
Myocardial injury after ischemia-reperfusion in mice deficient in Akt2 is associated with increased cardiac macrophage density.
American journal of physiology. Heart and circulatory physiology 2011;301(5):H1932-40.
2011: Philip Raake; J Reinkober; J Ritterhoff; H Tscheschner; Hugo A Katus; Walter J Koch; Patrick Most
Gene therapy targets in heart failure: the path to translation.
Clinical pharmacology and therapeutics 2011;90(4):542-53.
2011: Wei Yi; Yuexing Yuan; Qijun Zheng; Erhe Gao; Walter J Koch; Wayne Bond Lau; Rong Li; Yang Sun; Ling Tao; Xiaoliang Wang; Yajing Wang; Xufeng Wei; Xin-Liang Ma
Reduced cardioprotective action of adiponectin in high-fat diet-induced type II diabetic mice and its underlying mechanisms.
Antioxidants & redox signaling 2011;15(7):1779-88.
2011: Yan Zhang; Xiujun Duan; Jessica I Gold; Walter J Koch; Scot J Matkovich; Gerald W Dorn
Nuclear effects of G-protein receptor kinase 5 on histone deacetylase 5-regulated gene transcription in heart failure.
Circulation. Heart failure 2011;4(5):659-68.
2011: Henriette Brinks; Thierry Carrel; Andrea D Eckhart; Nicole Herzog; Hugo A Katus; Walter J Koch; Carolin Lerchenmüller; Paul J Mather; Sven T Pleger; Gang Qiu; Joseph Rabinowitz; David Rohde; Arjang Ruhparwar; Scott Silvestry; Mirko Voelkers; Patrick Most
S100A1 genetically targeted therapy reverses dysfunction of human failing cardiomyocytes.
Journal of the American College of Cardiology 2011;58(9):966-73.
2011: Xue Li; Valerie Myers; Jeffrey Robbins; Jianliang Song; Jin Zhang; Xue-Qian Zhang; Jocelyn Andrel; Tung O Chan; Joseph Y Cheung; Ibrul Chowdhury; Hajime Funakoshi; Terry Hyslop; Walter J Koch; Arthur M Feldman
Controlled and cardiac-restricted overexpression of the arginine vasopressin V1A receptor causes reversible left ventricular dysfunction through Gαq-mediated cell signaling.
Circulation 2011;124(5):572-81.
2011: Anthony S Fargnoli; Michael G Katz; Walter J Koch; Joseph J Rabinowitz; Hansell Stedman; Marina V Sumaroka; Charles Yarnall; Charles R Bridges
A pharmacokinetic analysis of molecular cardiac surgery with recirculation mediated delivery of βARKct gene therapy: developing a quantitative definition of the therapeutic window.
Journal of cardiac failure 2011;17(8):691-9.
2011: Shaowei Liu; Yi Liu; Yanzhuo Ma; Haifeng Pei; Yan Qu; Lu Sun; Erhe Gao; Walter J Koch; Wayne Bond Lau; Kun Lian; Haichang Wang; Rutao Wang; Xufeng Wei; Chenhai Xia; Wei Yi; Tao Yin; Ling Tao
Downregulation of adiponectin induced by tumor necrosis factor α is involved in the aggravation of posttraumatic myocardial ischemia/reperfusion injury.
Critical care medicine 2011;39(8):1935-43.
2011: Sven T Pleger; Gang Qiu; Philip Raake; Stefanie Schinkel; Changguang Shan; Christophe Weber; Oliver J Müller; Raffi Bekeredjian; Peter Boekstegers; Rabea Hinkel; Hugo A Katus; Walter J Koch; Jan Ksienzyk; Barbara Leuchs; Jochen Ludwig; Patrick Most
Cardiac AAV9-S100A1 gene therapy rescues post-ischemic heart failure in a preclinical large animal model.
Science translational medicine 2011;3(92):92ra64.
2011: Henriette Brinks; Amrit Das; Walter J Koch
A role for GRK2 in myocardial ischemic injury: indicators of a potential future therapy and diagnostic.
Future cardiology 2011;7(4):547-56.
2011: J D White; C Yarnall; A Fargnoli; A Henderson; D Holt; A Isidro; M G Katz; Walter J Koch; R Nolen-Walston; M Petrov; J Rabinowitz; H H Stedman; M Sumaroka; J B D Swain; D M Thesier; C Tomasulo; Liqing Wang; C R Bridges
Myocardial gene delivery using molecular cardiac surgery with recombinant adeno-associated virus vectors in vivo.
Gene therapy 2011;18(6):546-52.
2011: Michele Ciccarelli; J Kurt Chuprun; Giuseppe Rengo; Erhe Gao; Zhengyu Wei; Raymond J Peroutka; Jessica I Gold; Anna Gumpert; Mai Chen; Nicholas J Otis; Gerald W Dorn; Bruno Trimarco; guido iaccarino; Walter J Koch
G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia.
Circulation 2011;123(18):1953-62.
2011: Giuseppe Rengo; Anastasios Lymperopoulos; Dario Leosco; Walter J Koch
GRK2 as a novel gene therapy target in heart failure.
Journal of molecular and cellular cardiology 2011;50(5):785-92.
2011: Jean-François Jasmin; Giuseppe Rengo; Anastasios Lymperopoulos; Ratika Gupta; Gregory J Eaton; Kevin Quann; Donna M Gonzales; Isabelle Mercier; Walter J Koch; Michael P Lisanti
Caveolin-1 deficiency exacerbates cardiac dysfunction and reduces survival in mice with myocardial infarction.
American journal of physiology. Heart and circulatory physiology 2011;300(4):H1274-81.
2011: Philip W Raake; Walter J Koch; Patrick Most
Polymorphisms present in G-protein-coupled receptor kinases and their effect on β-blocker treatment.
Pharmacogenomics 2011;12(3):295-7.
2011: Ellina Cheskis Feiner; Paul Chung; Jean Francois Jasmin; Jin Zhang; Diana Whitaker-Menezes; Valerie Myers; Jianliang Song; Elizabeth W Feldman; Hajime Funakoshi; Brent R Degeorge; Rao V Yelamarty; Walter J Koch; Michael P Lisanti; Charles F McTiernan; Joseph Y Cheung; Michael R Bristow; Tung O Chan; Arthur M Feldman
Left ventricular dysfunction in murine models of heart failure and in failing human heart is associated with a selective decrease in the expression of caveolin-3.
Journal of cardiac failure 2011;17(3):253-63.
2011: Jufang Wang; Erhe Gao; Joseph Rabinowitz; Jianliang Song; Xue-Qian Zhang; Walter J Koch; Amy L Tucker; Tung O Chan; Arthur M Feldman; Joseph Y Cheung
Regulation of in vivo cardiac contractility by phospholemman: role of Na+/Ca2+ exchange.
American journal of physiology. Heart and circulatory physiology 2011;300(3):H859-68.
2011: Konstantinos Drosatos; Kalyani G Bharadwaj; Anastasios Lymperopoulos; Shota Ikeda; Raffay Khan; Yunying Hu; Rajiv Agarwal; Shuiqing Yu; Hongfeng Jiang; Susan F Steinberg; William S Blaner; Walter J Koch; Ira J Goldberg
Cardiomyocyte lipids impair β-adrenergic receptor function via PKC activation.
American journal of physiology. Endocrinology and metabolism 2011;300(3):E489-99.
2011: Xiongwen Chen; Hiroyuki Nakayama; Xiaoying Zhang; Xiaojie Ai; David M Harris; Mingxin Tang; Hongyu Zhang; Christopher Szeto; Kathryn Stockbower; Remus M Berretta; Andrea D Eckhart; Walter J Koch; Jeffery D Molkentin; Steven R Houser
Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy.
Journal of molecular and cellular cardiology 2011;50(3):460-70.
2011: Christopher M O'Connor; Walter J Koch; Douglas L Mann
Highlights of the 2010 scientific sessions of the Heart Failure Society of America, San Diego, California, September 12-15, 2010.
Journal of cardiac failure 2011;17(2):92-9.
2011: Michele Ciccarelli; Daniela Sorriento; Ersilia Cipolletta; Gaetano Santulli; Anna Fusco; Rui-Hai Zhou; Andrea D Eckhart; Karsten Peppel; Walter J Koch; Bruno Trimarco; guido iaccarino
Impaired neoangiogenesis in β₂-adrenoceptor gene-deficient mice: restoration by intravascular human β₂-adrenoceptor gene transfer and role of NFκB and CREB transcription factors.
British journal of pharmacology 2011;162(3):712-21.
2011: Anastasios Lymperopoulos; Giuseppe Rengo; Carmela Zincarelli; Jihee Kim; Walter J Koch
Adrenal beta-arrestin 1 inhibition in vivo attenuates post-myocardial infarction progression to heart failure and adverse remodeling via reduction of circulating aldosterone levels.
Journal of the American College of Cardiology 2011;57(3):356-65.
2011: Mirko Völkers; Christian Weidenhammer; Nicole Herzog; Gang Qiu; Kristin Spaich; Frederic von Wegner; Karsten Peppel; Oliver J Müller; Stefanie Schinkel; Joseph E Rabinowitz; Hans-Joerg Hippe; Henriette Brinks; Hugo A Katus; Walter J Koch; Andrea D Eckhart; Oliver Friedrich; Patrick Most
The inotropic peptide βARKct improves βAR responsiveness in normal and failing cardiomyocytes through G(βγ)-mediated L-type calcium current disinhibition.
Circulation research 2011;108(1):27-39.
2011: Zheng Maggie Huang; Jessica I Gold; Walter J Koch
G protein-coupled receptor kinases in normal and failing myocardium.
Frontiers in bioscience : a journal and virtual library 2011;16():3047-60.
2010: Erhe Gao; Yong Hong Lei; Xiying Shang; Z Maggie Huang; Lin Zuo; Matthieu Boucher; Qian Fan; J Kurt Chuprun; Xin L Ma; Walter J Koch
A novel and efficient model of coronary artery ligation and myocardial infarction in the mouse.
Circulation research 2010;107(12):1445-53.
2010: Henriette Brinks; Matthieu Boucher; Erhe Gao; J Kurt Chuprun; Stéphanie Pesant; Philip W Raake; Z Maggie Huang; Xiaoliang Wang; Gang Qiu; Anna Gumpert; David M Harris; Andrea D Eckhart; Patrick Most; Walter J Koch
Level of G protein-coupled receptor kinase-2 determines myocardial ischemia/reperfusion injury via pro- and anti-apoptotic mechanisms.
Circulation research 2010;107(9):1140-9.
2010: Henriette Brinks; Walter J Koch
betaARKct: a therapeutic approach for improved adrenergic signaling and function in heart disease.
Journal of cardiovascular translational research 2010;3(5):499-506.
2010: Hongyu Zhang; Xiongwen Chen; Erhe Gao; Scott M MacDonnell; Wei Wang; Mikhail Kolpakov; Hiroyuki Nakayama; Xiaoying Zhang; Naser Jaleel; David M Harris; Yingxin Li; Mingxin Tang; Remus M Berretta; Annarosa Leri; Jan Kajstura; Abdelkarim Sabri; Walter J Koch; Jeffery D Molkentin; Steven R Houser
Increasing cardiac contractility after myocardial infarction exacerbates cardiac injury and pump dysfunction.
Circulation research 2010;107(6):800-9.
2010: Arthur M Feldman; Thomas L Force; David Whellan; Paul F Bray; Joseph Y Cheung; Walter J Koch
Advancing the research mission in an academic department: the creation of a center for translational medicine.
Clinical and translational science 2010;3(4):178-81.
2010: Jibin Zhou; Hind Lal; Xiongwen Chen; Xiying Shang; Jianliang Song; Yingxin Li; Risto Kerkela; Bradley Doble; Katrina MacAulay; Morgan DeCaul; Walter J Koch; John Farber; James R Woodgett; Erhe Gao; Thomas Force
GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice.
The Journal of clinical investigation 2010;120(7):2280-91.
2010: Carmela Zincarelli; Stephen Soltys; Giuseppe Rengo; Walter J Koch; Joseph E Rabinowitz
Comparative cardiac gene delivery of adeno-associated virus serotypes 1-9 reveals that AAV6 mediates the most efficient transduction in mouse heart.
Clinical and translational science 2010;3(3):81-9.
2010: Giuseppe Rengo; Dario Leosco; Carmela Zincarelli; Massimo Marchese; Graziamaria Corbi; Daniela Liccardo; Amelia Filippelli; Nicola Ferrara; Michael P Lisanti; Walter J Koch; Anastasios Lymperopoulos
Adrenal GRK2 lowering is an underlying mechanism for the beneficial sympathetic effects of exercise training in heart failure.
American journal of physiology. Heart and circulatory physiology 2010;298(6):H2032-8.
2010: Mirko Voelkers; Mareen Salz; Nicole Herzog; Derk Frank; Nima Dolatabadi; Norbert Frey; Natalie Gude; Oliver Friedrich; Walter J Koch; Hugo A Katus; Mark A Sussman; Patrick Most
Orai1 and Stim1 regulate normal and hypertrophic growth in cardiomyocytes.
Journal of molecular and cellular cardiology 2010;48(6):1329-34.
2010: Anastasios Lymperopoulos; Giuseppe Rengo; Erhe Gao; Steven N Ebert; Gerald W Dorn; Walter J Koch
Reduction of sympathetic activity via adrenal-targeted GRK2 gene deletion attenuates heart failure progression and improves cardiac function after myocardial infarction.
The Journal of biological chemistry 2010;285(21):16378-86.
2010: Yajing Wang; Wayne Bond Lau; Erhe Gao; Ling Tao; Yuexing Yuan; Rong Li; Xiaoliang Wang; Walter J Koch; Xin-Liang Ma
Cardiomyocyte-derived adiponectin is biologically active in protecting against myocardial ischemia-reperfusion injury.
American journal of physiology. Endocrinology and metabolism 2010;298(3):E663-70.
2010: JuFang Wang; Erhe Gao; Jianliang Song; Xue-Qian Zhang; Jifen Li; Walter J Koch; Amy L Tucker; Kenneth D Philipson; Tung O Chan; Arthur M Feldman; Joseph Y Cheung
Phospholemman and beta-adrenergic stimulation in the heart.
American journal of physiology. Heart and circulatory physiology 2010;298(3):H807-15.
2010: Ling Tao; Yajing Wang; Erhe Gao; Hangxiang Zhang; Yuexing Yuan; Wayne B Lau; Lawrence Chan; Walter J Koch; Xin L Ma
Adiponectin: an indispensable molecule in rosiglitazone cardioprotection following myocardial infarction.
Circulation research 2010;106(2):409-17.
2010: Raphael E Bonita; Philip Raake; Nicholas J Otis; J Kurt Chuprun; Talya Spivack; Abhijit Dasgupta; David Whellan; Paul J Mather; Walter J Koch
Dynamic changes in lymphocyte GRK2 levels in cardiac transplant patients: a biomarker for left ventricular function.
Clinical and translational science 2010;3(1):14-8.
2009: Giuseppe Rengo; Anastasios Lymperopoulos; Walter J Koch
Future g protein-coupled receptor targets for treatment of heart failure.
Current treatment options in cardiovascular medicine 2009;11(4):328-38.
2009: JuFang Wang; Tung O Chan; Xue-Qian Zhang; Erhe Gao; Jianliang Song; Walter J Koch; Arthur M Feldman; Joseph Y Cheung
Induced overexpression of Na+/Ca2+ exchanger transgene: altered myocyte contractility, [Ca2+]i transients, SR Ca2+ contents, and action potential duration.
American journal of physiology. Heart and circulatory physiology 2009;297(2):H590-601.
2009: Anastasios Lymperopoulos; Giuseppe Rengo; Carmela Zincarelli; Jihee Kim; Stephen Soltys; Walter J Koch
An adrenal beta-arrestin 1-mediated signaling pathway underlies angiotensin II-induced aldosterone production in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(14):5825-30.
2009: Walter J Koch
Heart failure gene therapy: closer to reality. Professor Walter Koch speaks to Christine Forder, commissioning editor.
Future cardiology 2009;5(2):117-9.
2009: Erhe Gao; Walter J Koch
Is erythropoietin behind maladaptive anemic heart failure?
American journal of physiology. Heart and circulatory physiology 2009;296(3):H559-60.
2009: Xiang-Ying Jiao; Erhe Gao; Yuexin Yuan; Yajing Wang; Wayne Bond Lau; Walter J Koch; Xin-Liang Ma; Ling Tao
INO-4885 [5,10,15,20-tetra[N-(benzyl-4'-carboxylate)-2-pyridinium]-21H,23H-porphine iron(III) chloride], a peroxynitrite decomposition catalyst, protects the heart against reperfusion injury in mice.
The Journal of pharmacology and experimental therapeutics 2009;328(3):777-84.
2009: Yajing Wang; Erhe Gao; Ling Tao; Wayne Bond Lau; Yuexin Yuan; Barry J Goldstein; Bernard L Lopez; Theodore A Christopher; Rong Tian; Walter J Koch; Xin-Liang Ma
AMP-activated protein kinase deficiency enhances myocardial ischemia/reperfusion injury but has minimal effect on the antioxidant/antinitrative protection of adiponectin.
Circulation 2009;119(6):835-44.
2009: Rui-Hai Zhou; Stephanie Pesant; Heather Cohn; Stephen Soltys; Walter J Koch; Andrea D Eckhart
Negative regulation of VEGF signaling in human coronary artery endothelial cells by G protein-coupled receptor kinase 5.
Clinical and translational science 2009;2(1):57-61.
2009: Hui-Rong Liu; Ling Tao; Erhe Gao; Yan Qu; Wayne Bond Lau; Bernard L Lopez; Theodore A Christopher; Walter J Koch; Tian-Li Yue; Xin-Liang Ma
Rosiglitazone inhibits hypercholesterolaemia-induced myeloperoxidase upregulation--a novel mechanism for the cardioprotective effects of PPAR agonists.
Cardiovascular research 2009;81(2):344-52.
2009: Giuseppe Rengo; Anastasios Lymperopoulos; Carmela Zincarelli; Maria Donniacuo; Stephen Soltys; Joseph E Rabinowitz; Walter J Koch
Myocardial adeno-associated virus serotype 6-betaARKct gene therapy improves cardiac function and normalizes the neurohormonal axis in chronic heart failure.
Circulation 2009;119(1):89-98.
2009: Ya-bing Ma; Bao-ying Li; Hai-qing Gao; Min Yao; Walter J Koch; Andrea D Eckhart; Rui-Hai Zhou
[Activation of sterol regulatory element binding protein and its involvement in endothelial cell migration].
Zhonghua bing li xue za zhi Chinese journal of pathology 2009;38(1):50-4.
2009: David M Harris; Xiongwen Chen; Stéphanie Pesant; Heather Cohn; Scott M MacDonnell; Matthieu Boucher; Leif E Vinge; Philip Raake; Susan R Moraca; Dongjun Li; Patrick Most; Steven R Houser; Walter J Koch; Andrea D Eckhart
Inhibition of angiotensin II Gq signaling augments beta-adrenergic receptor mediated effects in a renal artery stenosis model of high blood pressure.
Journal of molecular and cellular cardiology 2009;46(1):100-7.
2008: Heather Cohn; David M Harris; Stephanie Pesant; Michael Pfeiffer; Rui-Hai Zhou; Walter J Koch; Gerald W Dorn; Andrea D Eckhart
Inhibition of vascular smooth muscle G protein-coupled receptor kinase 2 enhances alpha1D-adrenergic receptor constriction.
American journal of physiology. Heart and circulatory physiology 2008;295(4):H1695-704.
2008: Brent R DeGeorge; Marc Rosenberg; Volker Eckstein; Erhe Gao; Nicole Herzog; Hugo A Katus; Walter J Koch; Norbert Frey; Patrick Most
BMP-2 and FGF-2 synergistically facilitate adoption of a cardiac phenotype in somatic bone marrow c-kit+/Sca-1+ stem cells.
Clinical and translational science 2008;1(2):116-25.
2008: Tung O Chan; Hajime Funakoshi; Jianliang Song; Xue-Qian Zhang; JuFang Wang; Paul H Chung; Brent R DeGeorge; Xue Li; Jin Zhang; David E Herrmann; Maura Diamond; Eman Hamad; Steven R Houser; Walter J Koch; Joseph Y Cheung; Arthur M Feldman
Cardiac-restricted overexpression of the A(2A)-adenosine receptor in FVB mice transiently increases contractile performance and rescues the heart failure phenotype in mice overexpressing the A(1)-adenosine receptor.
Clinical and translational science 2008;1(2):126-33.
2008: Jeffrey S Martini; Philip Raake; Leif Erik Vinge; Brent R DeGeorge; Brent DeGeorge; J Kurt Chuprun; David M Harris; Erhe Gao; Andrea D Eckhart; Julie A Pitcher; Walter J Koch
Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(34):12457-62.
2008: Ayanna S Augustus; Jonathan Buchanan; Ellen Gutman; Giuseppe Rengo; Richard G Pestell; Paolo Fortina; Walter J Koch; Andre Bensadoun; E Dale Abel; Michael P Lisanti
Hearts lacking caveolin-1 develop hypertrophy with normal cardiac substrate metabolism.
Cell cycle (Georgetown, Tex.) 2008;7(16):2509-18.
2008: Philip W Raake; Leif Erik Vinge; Erhe Gao; Matthieu Boucher; Giuseppe Rengo; Xiongwen Chen; Brent R DeGeorge; Scot Matkovich; Steven R Houser; Patrick Most; Andrea D Eckhart; Gerald W Dorn; Walter J Koch
G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure.
Circulation research 2008;103(4):413-22.
2008: Ayanna S Augustus; Jonathan Buchanan; Sankar Addya; Giuseppe Rengo; Richard G Pestell; Paolo Fortina; Walter J Koch; Andre Bensadoun; E Dale Abel; Michael P Lisanti
Substrate uptake and metabolism are preserved in hypertrophic caveolin-3 knockout hearts.
American journal of physiology. Heart and circulatory physiology 2008;295(2):H657-66.
2008: Brent R DeGeorge; Walter J Koch
Gi/o signaling and its potential role in cardioprotection.
Expert review of cardiovascular therapy 2008;6(6):785-7.
2008: Leif Erik Vinge; Philip W Raake; Walter J Koch
Gene therapy in heart failure.
Circulation research 2008;102(12):1458-70.
2008: Matthieu Boucher; Stéphanie Pesant; Yong Hong Lei; Natasha Nanton; Patrick Most; Andrea D Eckhart; Walter J Koch; Erhe Gao
Simultaneous administration of insulin-like growth factor-1 and darbepoetin alfa protects the rat myocardium against myocardial infarction and enhances angiogenesis.
Clinical and translational science 2008;1(1):13-20.
2008: Stephen B Liggett; Sharon Cresci; Reagan J Kelly; Faisal M Syed; Scot J Matkovich; Harvey S Hahn; Abhinav Diwan; Jeffrey S Martini; Li Sparks; Rohan R Parekh; John A Spertus; Walter J Koch; Sharon L R Kardia; Gerald W Dorn
A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure.
Nature medicine 2008;14(5):510-7.
2008: Dario Leosco; Giuseppe Rengo; guido iaccarino; Luca Golino; Massimo Marchese; Francesca Fortunato; Carmela Zincarelli; Emma Sanzari; Michele Ciccarelli; Gennaro Galasso; Giovanna Giuseppina Altobelli; Valeria Conti; Gianfranco Matrone; Vincenzo Cimini; Nicola Ferrara; Amelia Filippelli; Walter J Koch; Franco Rengo
Exercise promotes angiogenesis and improves beta-adrenergic receptor signalling in the post-ischaemic failing rat heart.
Cardiovascular research 2008;78(2):385-94.
2008: Leif Erik Vinge; Thomas G von Lueder; Ellen Aasum; Erik Qvigstad; Jørgen Gravning; Ole-Jakob How; Thor Edvardsen; Reidar Bjørnerheim; Mohammed Shakil Ahmed; Birthe W Mikkelsen; Erik Oie; Toril Attramadal; Tor Skomedal; Otto A Smiseth; Walter J Koch; Terje S Larsen; Håvard Attramadal
Cardiac-restricted expression of the carboxyl-terminal fragment of GRK3 Uncovers Distinct Functions of GRK3 in regulation of cardiac contractility and growth: GRK3 controls cardiac alpha1-adrenergic receptor responsiveness.
The Journal of biological chemistry 2008;283(16):10601-10.
2008: Sven T Pleger; David M Harris; Changguang Shan; Leif E Vinge; J Kurt Chuprun; Brett Berzins; Wiebke Pleger; Charles Druckman; Mirko Völkers; Jörg Heierhorst; Erik Øie; Andrew Remppis; Hugo A Katus; Rosario Scalia; Andrea D Eckhart; Walter J Koch; Patrick Most
Endothelial S100A1 modulates vascular function via nitric oxide.
Circulation research 2008;102(7):786-94.
2008: Brent R DeGeorge; Erhe Gao; Matthieu Boucher; Leif E Vinge; Jeffrey S Martini; Philip W Raake; J Kurt Chuprun; David M Harris; Gilbert W Kim; Stephen Soltys; Andrea D Eckhart; Walter J Koch
Targeted inhibition of cardiomyocyte Gi signaling enhances susceptibility to apoptotic cell death in response to ischemic stress.
Circulation 2008;117(11):1378-87.
2008: Ming Zhu; Agnieszka A Gach; GongXin Liu; Xiaomei Xu; Chee Chew Lim; Julie X Zhang; Lan Mao; Kurt Chuprun; Walter J Koch; Ronglih Liao; Gideon Koren; Burns C Blaxall; Ulrike Mende
Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G alpha o* protein.
American journal of physiology. Heart and circulatory physiology 2008;294(3):H1335-47.
2008: Anastasios Lymperopoulos; Giuseppe Rengo; Carmela Zincarelli; Stephen Soltys; Walter J Koch
Modulation of adrenal catecholamine secretion by in vivo gene transfer and manipulation of G protein-coupled receptor kinase-2 activity.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(2):302-7.
2007: Sven T Pleger; Patrick Most; Walter J Koch
Recent findings into the potential of gene therapy to reverse heart failure.
Expert opinion on biological therapy 2007;7(12):1781-4.
2007: Anastasios Lymperopoulos; Giuseppe Rengo; Walter J Koch
Adrenal adrenoceptors in heart failure: fine-tuning cardiac stimulation.
Trends in molecular medicine 2007;13(12):503-11.
2007: Scott M MacDonnell; Hajime Kubo; David M Harris; Xiongwen Chen; Remus M Berretta; Mary F Barbe; Stephen Kolwicz; Patricia O Reger; Andrea D Eckhart; Brian F Renna; Walter J Koch; Steven R Houser; Joseph R Libonati
Calcineurin inhibition normalizes beta-adrenergic responsiveness in the spontaneously hypertensive rat.
American journal of physiology. Heart and circulatory physiology 2007;293(5):H3122-9.
2007: Leif Erik Vinge; Kjetil Wessel Andressen; Toril Attramadal; Geir Oystein Andersen; Mohammed Shakil Ahmed; Karsten Peppel; Walter J Koch; Neil J Freedman; Finn Olav Levy; Tor Skomedal; Jan-Bjørn Osnes; Håvard Attramadal
Substrate specificities of g protein-coupled receptor kinase-2 and -3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function.
Molecular pharmacology 2007;72(3):582-91.
2007: Dario Leosco; Giuseppe Rengo; guido iaccarino; Amelia Filippelli; Anastasios Lymperopoulos; Carmela Zincarelli; Francesca Fortunato; Luca Golino; Massimo Marchese; Giovanni Esposito; Antonio Rapacciuolo; Barbara Rinaldi; Nicola Ferrara; Walter J Koch; Franco Rengo
Exercise training and beta-blocker treatment ameliorate age-dependent impairment of beta-adrenergic receptor signaling and enhance cardiac responsiveness to adrenergic stimulation.
American journal of physiology. Heart and circulatory physiology 2007;293(3):H1596-603.
2007: Paloma H Giangrande; JianXin Zhang; Alice Tanner; Andrea D Eckhart; Rachel E Rempel; Eran R Andrechek; Juliana M Layzer; Janelle R Keys; Per-Otto Hagen; Joseph R Nevins; Walter J Koch; Bruce A Sullenger
Distinct roles of E2F proteins in vascular smooth muscle cell proliferation and intimal hyperplasia.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(32):12988-93.
2007: Patrick Most; Andrew Remppis; Sven T Pleger; Hugo A Katus; Walter J Koch
S100A1: a novel inotropic regulator of cardiac performance. Transition from molecular physiology to pathophysiological relevance.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(2):R568-77.
2007: Thomas Force; Kathleen Woulfe; Walter J Koch; Risto Kerkelä
Molecular scaffolds regulate bidirectional crosstalk between Wnt and classical seven-transmembrane-domain receptor signaling pathways.
Science's STKE : signal transduction knowledge environment 2007;2007(397):pe41.
2007: Hangxiang Zhang; Ling Tao; Xiangying Jiao; Erhe Gao; Bernard L Lopez; Theodore A Christopher; Walter J Koch; Xin L Ma
Nitrative thioredoxin inactivation as a cause of enhanced myocardial ischemia/reperfusion injury in the aging heart.
Free radical biology & medicine 2007;43(1):39-47.
2007: Erhe Gao; Matthieu Boucher; J Kurt Chuprun; Rui-Hai Zhou; Andrea D Eckhart; Walter J Koch
Darbepoetin alfa, a long-acting erythropoietin analog, offers novel and delayed cardioprotection for the ischemic heart.
American journal of physiology. Heart and circulatory physiology 2007;293(1):H60-8.
2007: Sven T Pleger; Matthieu Boucher; Patrick Most; Walter J Koch
Targeting myocardial beta-adrenergic receptor signaling and calcium cycling for heart failure gene therapy.
Journal of cardiac failure 2007;13(5):401-14.
2007: Melanie Boerries; Patrick Most; Jonathan R Gledhill; John E Walker; Hugo A Katus; Walter J Koch; Ueli Aebi; Cora-Ann Schoenenberger
Ca2+ -dependent interaction of S100A1 with F1-ATPase leads to an increased ATP content in cardiomyocytes.
Molecular and cellular biology 2007;27(12):4365-73.
2007: Arthur M Feldman; Walter J Koch; T L Force
Developing strategies to link basic cardiovascular sciences with clinical drug development: another opportunity for translational sciences.
Clinical pharmacology and therapeutics 2007;81(6):887-92.
2007: Sven T Pleger; Patrick Most; Matthieu Boucher; Stephen Soltys; J Kurt Chuprun; Wiebke Pleger; Erhe Gao; Abhijit Dasgupta; Giuseppe Rengo; Andrew Remppis; Hugo A Katus; Andrea D Eckhart; Joseph E Rabinowitz; Walter J Koch
Stable myocardial-specific AAV6-S100A1 gene therapy results in chronic functional heart failure rescue.
Circulation 2007;115(19):2506-15.
2007: Erin J Whalen; Matthew W Foster; Akio Matsumoto; Kentaro Ozawa; Jonathan D Violin; Loretta G Que; Christopher D Nelson; Moran Benhar; Janelle R Keys; Howard A Rockman; Walter J Koch; Yehia A Daaka; Robert J Lefkowitz; Jonathan S Stamler
Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2.
Cell 2007;129(3):511-22.
2007: Dario Leosco; Giuseppe Rengo; guido iaccarino; Emma Sanzari; Luca Golino; Gabriella De Lisa; Carmela Zincarelli; Francesca Fortunato; Michele Ciccarelli; Vincenzo Cimini; Giovanna Giuseppina Altobelli; Federico Piscione; Gennaro Galasso; Bruno Trimarco; Walter J Koch; Franco Rengo
Prior exercise improves age-dependent vascular endothelial growth factor downregulation and angiogenesis responses to hind-limb ischemia in old rats.
The journals of gerontology. Series A, Biological sciences and medical sciences 2007;62(5):471-80.
2007: Hajime Funakoshi; Lefteris C Zacharia; Zhonghua Tang; Jin Zhang; Ling L Lee; Julie C Good; David E Herrmann; Yoshihiro Higuchi; Walter J Koch; Edwin K Jackson; Tung O Chan; Arthur M Feldman
A1 adenosine receptor upregulation accompanies decreasing myocardial adenosine levels in mice with left ventricular dysfunction.
Circulation 2007;115(17):2307-15.
2007: Dario Leosco; Francesca Fortunato; Giuseppe Rengo; guido iaccarino; Emma Sanzari; Luca Golino; Carmela Zincarelli; Vincenzo Canonico; Massimo Marchese; Walter J Koch; Franco Rengo
Lymphocyte G-protein-coupled receptor kinase-2 is upregulated in patients with Alzheimer's disease.
Neuroscience letters 2007;415(3):279-82.
2007: Ling Tao; Erhe Gao; Xiangying Jiao; Yuexing Yuan; Shuzhuang Li; Theodore A Christopher; Bernard L Lopez; Walter J Koch; Lawrence Chan; Barry J Goldstein; Xin L Ma
Adiponectin cardioprotection after myocardial ischemia/reperfusion involves the reduction of oxidative/nitrative stress.
Circulation 2007;115(11):1408-16.
2007: Anastasios Lymperopoulos; Giuseppe Rengo; Hajime Funakoshi; Andrea D Eckhart; Walter J Koch
Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure.
Nature medicine 2007;13(3):315-23.
2007: Mirko Völkers; Christopher M Loughrey; Niall Macquaide; Andrew Remppis; Brent R DeGeorge; Frederic V Wegner; Oliver Friedrich; Rainer H A Fink; Walter J Koch; Godfrey L Smith; Patrick Most
S100A1 decreases calcium spark frequency and alters their spatial characteristics in permeabilized adult ventricular cardiomyocytes.
Cell calcium 2007;41(2):135-43.
2007: Patrick Most; Walter J Koch
S100A1: a calcium-modulating inotropic prototype for future clinical heart failure therapy.
Future cardiology 2007;3(1):5-11.
2007: Brent R DeGeorge; Walter J Koch
Beta blocker specificity: a building block toward personalized medicine.
The Journal of clinical investigation 2007;117(1):86-9.
2006: Hajime Funakoshi; Tung O Chan; Julie C Good; Joseph R Libonati; Jarkko Piuhola; Xiongwen Chen; Scott M MacDonnell; Ling L Lee; David E Herrmann; Jin Zhang; Jeffrey Martini; Timothy Palmer; Atsushi Sanbe; Jeffrey Robbins; Steven R Houser; Walter J Koch; Arthur M Feldman
Regulated overexpression of the A1-adenosine receptor in mice results in adverse but reversible changes in cardiac morphology and function.
Circulation 2006;114(21):2240-50.
2006: Sven T Pleger; Patrick Most; Beatrix Heidt; M Voelkers; J A Hata; Hugo A Katus; Andrew Remppis; Walter J Koch
S100A1 gene transfer in myocardium.
European journal of medical research 2006;11(10):418-22.
2006: Scot J Matkovich; Abhinav Diwan; Justin L Klanke; Daniel J Hammer; Yehia Marreez; Amy Odley; Eric W Brunskill; Walter J Koch; Robert J Schwartz; Gerald W Dorn
Cardiac-specific ablation of G-protein receptor kinase 2 redefines its roles in heart development and beta-adrenergic signaling.
Circulation research 2006;99(9):996-1003.
2006: Ling Tao; Erhe Gao; Aihua Hu; C Coletti; Y Wang; Theodore A Christopher; Bernard L Lopez; Walter J Koch; Xin L Ma
Thioredoxin reduces post-ischemic myocardial apoptosis by reducing oxidative/nitrative stress.
British journal of pharmacology 2006;149(3):311-8.
2006: Ling Tao; Xiangying Jiao; Erhe Gao; Wayne B Lau; Yuexing Yuan; Bernard Lopez; Theodore A Christopher; Satish P RamachandraRao; William Williams; Garry J Southan; Kumar Sharma; Walter J Koch; Xin L Ma
Nitrative inactivation of thioredoxin-1 and its role in postischemic myocardial apoptosis.
Circulation 2006;114(13):1395-402.
2006: Patrick Most; Hanna Seifert; Erhe Gao; Hajime Funakoshi; Mirko Völkers; Jörg Heierhorst; Andrew Remppis; Sven T Pleger; Brent R DeGeorge; Andrea D Eckhart; Arthur M Feldman; Walter J Koch
Cardiac S100A1 protein levels determine contractile performance and propensity toward heart failure after myocardial infarction.
Circulation 2006;114(12):1258-68.
2006: Michael Hambleton; Harvey Hahn; Sven T Pleger; Matthew C Kuhn; Raisa Klevitsky; Andrew N Carr; Thomas F Kimball; Timothy E Hewett; Gerald W Dorn; Walter J Koch; Jeffery D Molkentin
Pharmacological- and gene therapy-based inhibition of protein kinase Calpha/beta enhances cardiac contractility and attenuates heart failure.
Circulation 2006;114(6):574-82.
2006: Aihua Hu; Xiangying Jiao; Erhe Gao; Walter J Koch; Said Sharifi-Azad; Zvi Grunwald; Xin L Ma; Jian-Zhong Sun
Chronic beta-adrenergic receptor stimulation induces cardiac apoptosis and aggravates myocardial ischemia/reperfusion injury by provoking inducible nitric-oxide synthase-mediated nitrative stress.
The Journal of pharmacology and experimental therapeutics 2006;318(2):469-75.
2006: Anastasios Lymperopoulos; Georgios Karkoulias; Walter J Koch; Christodoulos S Flordellis
Alpha2-adrenergic receptor subtype-specific activation of NF-kappaB in PC12 cells.
Neuroscience letters 2006;402(3):210-5.
2006: Jonathan A Hata; Matthew L Williams; Jacob N Schroder; Brian Lima; Janelle R Keys; Burns C Blaxall; Jason A Petrofski; Andre Jakoi; Carmelo A Milano; Walter J Koch
Lymphocyte levels of GRK2 (betaARK1) mirror changes in the LVAD-supported failing human heart: lower GRK2 associated with improved beta-adrenergic signaling after mechanical unloading.
Journal of cardiac failure 2006;12(5):360-8.
2006: David M Harris; Andrea D Eckhart; Walter J Koch
Galphaq and its Aktions.
Journal of molecular and cellular cardiology 2006;40(5):589-92.
2006: Sven T Pleger; Walter J Koch
The yin and yang of increased beta-adrenergic signaling: beta1-adrenergic genetic polymorphism and protection against acute myocardial ischemic injury.
American journal of physiology. Heart and circulatory physiology 2006;290(4):H1408-9.
2005: Jason A Petrofski; Jonathan A Hata; Matthew L Williams; Cyrus J Parsa; Richard B Thompson; Steven I Hanish; Thomas R Gehrig; Walter J Koch; Carmelo A Milano
A Gbetagamma inhibitor reduces intimal hyperplasia in aortocoronary saphenous vein grafts.
The Journal of thoracic and cardiovascular surgery 2005;130(6):1683-90.
2005: Sarah Kettlewell; Patrick Most; Susan Currie; Walter J Koch; Godfrey L Smith
S100A1 increases the gain of excitation-contraction coupling in isolated rabbit ventricular cardiomyocytes.
Journal of molecular and cellular cardiology 2005;39(6):900-10.
2005: Sven T Pleger; Andrew Remppis; Beatrix Heidt; Mirko Völkers; J Kurt Chuprun; Matthew Kuhn; Rui-Hai Zhou; Erhe Gao; Gabor Szabo; Dieter Weichenhan; Oliver J Müller; Andrea D Eckhart; Hugo A Katus; Walter J Koch; Patrick Most
S100A1 gene therapy preserves in vivo cardiac function after myocardial infarction.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(6):1120-9.
2005: guido iaccarino; Michele Ciccarelli; Daniela Sorriento; Gennaro Galasso; Alfonso Campanile; Gaetano Santulli; Ersilia Cipolletta; Vincenzo Cerullo; Vincenzo Cimini; Giovanna Giuseppina Altobelli; Federico Piscione; Ornella Priante; Lucio Pastore; Massimo Chiariello; Francesco Salvatore; Walter J Koch; Bruno Trimarco
Ischemic neoangiogenesis enhanced by beta2-adrenergic receptor overexpression: a novel role for the endothelial adrenergic system.
Circulation research 2005;97(11):1182-9.
2005: Ryan C Fields; Kamran Baig; Jeffrey G Gaca; Luther G Milton; Walter J Koch; Jeffrey H Lawson
Reduction of vascular intimal-medial hyperplasia in polytetrafluoroethylene arteriovenous grafts via expression of an inhibitor of G protein signaling.
Annals of vascular surgery 2005;19(5):712-8.
2005: guido iaccarino; Emanuele Barbato; Ersilia Cipolletta; Vincenzo De Amicis; Kenneth B Margulies; Dario Leosco; Bruno Trimarco; Walter J Koch
Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure.
European heart journal 2005;26(17):1752-8.
2005: Hendrik T Tevaearai; G Brant Walton; Janelle R Keys; Walter J Koch; Andrea D Eckhart
Acute ischemic cardiac dysfunction is attenuated via gene transfer of a peptide inhibitor of the beta-adrenergic receptor kinase (betaARK1).
The journal of gene medicine 2005;7(9):1172-7.
2005: Sven T Pleger; Walter J Koch
Translational medicine in genetic familial diseases: from the autopsy room to the molecular bench and vice versa.
Human pathology 2005;36(7):708-9.
2005: Scott M MacDonnell; Hajime Kubo; Deborah L Crabbe; Brian F Renna; Patricia O Reger; Jun Mohara; L Ashley Smithwick; Walter J Koch; Steven R Houser; Joseph R Libonati
Improved myocardial beta-adrenergic responsiveness and signaling with exercise training in hypertension.
Circulation 2005;111(25):3420-8.
2005: Cyrus J Parsa; Robyn C Reed; G Brant Walton; Laura S Pascal; Richard B Thompson; Jason A Petrofski; Sitaram M Emani; Francisco Folgar; Ryan U Riel; Christopher V Nicchitta; Walter J Koch
Catheter-mediated subselective intracoronary gene delivery to the rabbit heart: introduction of a novel method.
The journal of gene medicine 2005;7(5):595-603.
2005: Hideo Tachibana; Sathyamangla V Naga Prasad; Robert J Lefkowitz; Walter J Koch; Howard A Rockman
Level of beta-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure.
Circulation 2005;111(5):591-7.
2005: Patrick Most; Melanie Boerries; Carmen Eicher; Christopher Schweda; Mirko Völkers; Thilo Wedel; Stefan Söllner; Hugo A Katus; Andrew Remppis; Ueli Aebi; Walter J Koch; Cora-Ann Schoenenberger
Distinct subcellular location of the Ca2+-binding protein S100A1 differentially modulates Ca2+-cycling in ventricular rat cardiomyocytes.
Journal of cell science 2005;118(Pt 2):421-31.
2005: Hui-Rong Liu; Erhe Gao; Aihua Hu; Ling Tao; Yan Qu; Patrick Most; Walter J Koch; Theodore A Christopher; Bernard L Lopez; Emad S Alnemri; Antonis S Zervos; Xin L Ma
Role of Omi/HtrA2 in apoptotic cell death after myocardial ischemia and reperfusion.
Circulation 2005;111(1):90-6.
2005: J Mark Jones; Walter J Koch
Cardiac gene delivery using DNA-adenoviral constructs.
Methods in molecular medicine 2005;112():49-57.
2005: J Mark Jones; Walter J Koch
Gene therapy approaches to cardiovascular disease.
Methods in molecular medicine 2005;112():15-35.
2004: Gökhan M Mutlu; Walter J Koch; Phillip H. Factor
Alveolar epithelial beta 2-adrenergic receptors: their role in regulation of alveolar active sodium transport.
American journal of respiratory and critical care medicine 2004;170(12):1270-5.
2004: Patrick Most; Sven T Pleger; Mirko Völkers; Beatrix Heidt; Melanie Boerries; Dieter Weichenhan; Eva Löffler; Paul Janssen; Andrea D Eckhart; Jeffrey Martini; Matthew L Williams; Hugo A Katus; Andrew Remppis; Walter J Koch
Cardiac adenoviral S100A1 gene delivery rescues failing myocardium.
The Journal of clinical investigation 2004;114(11):1550-63.
2004: J Mark Jones; Jason A Petrofski; Kenneth H Wilson; CHARLES STEENBERGEN; Walter J Koch; Carmelo A Milano
beta2 adrenoceptor gene therapy ameliorates left ventricular dysfunction following cardiac surgery.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2004;26(6):1161-8.
2004: J Mark Jones; Kenneth H Wilson; CHARLES STEENBERGEN; Walter J Koch; Carmelo A Milano
Dose dependent effects of cardiac beta2 adrenoceptor gene therapy.
The Journal of surgical research 2004;122(1):113-20.
2004: Zhengyu Luo; Maria Palasis; Midori Yamakawa; Louis X Liu; Karen A Vincent; Leonard Trudell; Geoffrey A Akita; Walter J Koch; Seng Cheng; Richard J Gregory; Canwen Jiang
Catheter-mediated delivery of adenoviral vectors expressing beta-adrenergic receptor kinase C-terminus inhibits intimal hyperplasia and luminal stenosis in rabbit iliac arteries.
The journal of gene medicine 2004;6(10):1061-8.
2004: Jacob N Schroder; Matthew L Williams; Walter J Koch
Gene delivery approaches to heart failure treatment.
Expert opinion on biological therapy 2004;4(9):1413-22.
2004: Ling Tao; Erhe Gao; Nathan S Bryan; Yan Qu; Hui-Rong Liu; Aihua Hu; Theodore A Christopher; Bernard L Lopez; Junji Yodoi; Walter J Koch; Martin Feelisch; Xin L Ma
Cardioprotective effects of thioredoxin in myocardial ischemia and reperfusion: role of S-nitrosation [corrected].
Proceedings of the National Academy of Sciences of the United States of America 2004;101(31):11471-6.
2004: Walter J Koch
Genetic and phenotypic targeting of beta-adrenergic signaling in heart failure.
Molecular and cellular biochemistry 2004;263(1-2):5-9.
2004: Hendrik T Tevaearai; Walter J Koch
Molecular restoration of beta-adrenergic receptor signaling improves contractile function of failing hearts.
Trends in cardiovascular medicine 2004;14(6):252-6.
2004: Jonathan A Hata; Matthew L Williams; Walter J Koch
Genetic manipulation of myocardial beta-adrenergic receptor activation and desensitization.
Journal of molecular and cellular cardiology 2004;37(1):11-21.
2004: Cyrus J Parsa; Jihee Kim; Ryan U Riel; Laura S Pascal; Richard B Thompson; Jason A Petrofski; Akio Matsumoto; Jonathan S Stamler; Walter J Koch
Cardioprotective effects of erythropoietin in the reperfused ischemic heart: a potential role for cardiac fibroblasts.
The Journal of biological chemistry 2004;279(20):20655-62.
2004: Katharina Foerster; Tomas Kaeferstein; Ferdi Groner; Stefan Engelhardt; Jan Matthes; Walter J Koch; Martin J Lohse; Stefan Herzig
Calcium channel function and regulation in beta 1- and beta 2-adrenoceptor transgenic mice.
Naunyn-Schmiedeberg's archives of pharmacology 2004;369(5):490-5.
2004: Haiyan Tong; Howard A Rockman; Walter J Koch; CHARLES STEENBERGEN; Elizabeth Murphy
G protein-coupled receptor internalization signaling is required for cardioprotection in ischemic preconditioning.
Circulation research 2004;94(8):1133-41.
2004: Matthew L Williams; Jonathan A Hata; Jacob N Schroder; Edward Rampersaud; Jason A Petrofski; Andre Jakoi; Carmelo A Milano; Walter J Koch
Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts.
Circulation 2004;109(13):1590-3.
2004: Andrew Remppis; Sven T Pleger; Patrick Most; Jan Lindenkamp; Philipp Ehlermann; Christopher Schweda; Eva Löffler; Dieter Weichenhan; Wolfram Zimmermann; Thomas Eschenhagen; Walter J Koch; Hugo A Katus
S100A1 gene transfer: a strategy to strengthen engineered cardiac grafts.
The journal of gene medicine 2004;6(4):387-94.
2004: Sitaram M Emani; Ashish S Shah; Michael K Bowman; David C White; Sitaramesh Emani; Donald D Glower; Walter J Koch
Right ventricular targeted gene transfer of a beta-adrenergic receptor kinase inhibitor improves ventricular performance after pulmonary artery banding.
The Journal of thoracic and cardiovascular surgery 2004;127(3):787-93.
2004: Richard B Thompson; Katrin Rungwerth; Walter J Koch
Gene therapy for heart failure.
Annals of medicine 2004;36 Suppl 1():106-15.
2004: Matthew L Williams; Walter J Koch
Viral-based myocardial gene therapy approaches to alter cardiac function.
Annual review of physiology 2004;66():49-75.
2004: Jason A Petrofski; Jonathan A Hata; Thomas R Gehrig; Steven I Hanish; Matthew L Williams; Richard B Thompson; Cyrus J Parsa; Walter J Koch; Carmelo A Milano
Gene delivery to aortocoronary saphenous vein grafts in a large animal model of intimal hyperplasia.
The Journal of thoracic and cardiovascular surgery 2004;127(1):27-33.
2004: Janelle R Keys; Walter J Koch
The adrenergic pathway and heart failure.
Recent progress in hormone research 2004;59():13-30.
2004: guido iaccarino; Walter J Koch
In vivo adenoviral-mediated gene transfer of the beta ARKct to study the role of G beta gamma in arterial restenosis.
Methods in molecular biology (Clifton, N.J.) 2004;237():181-92.
2003: Patrick Most; Melanie Boerries; Carmen Eicher; Christopher Schweda; Philipp Ehlermann; Sven T Pleger; Eva Loeffler; Walter J Koch; Hugo A Katus; Cora-Ann Schoenenberger; Andrew Remppis
Extracellular S100A1 protein inhibits apoptosis in ventricular cardiomyocytes via activation of the extracellular signal-regulated protein kinase 1/2 (ERK1/2).
The Journal of biological chemistry 2003;278(48):48404-12.
2003: Katharina Foerster; Ferdi Groner; Jan Matthes; Walter J Koch; Lutz Birnbaumer; Stefan Herzig
Cardioprotection specific for the G protein Gi2 in chronic adrenergic signaling through beta 2-adrenoceptors.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):14475-80.
2003: Janelle R Keys; Emily A Greene; Chris J Cooper; Sathyamangla V Naga Prasad; Howard A Rockman; Walter J Koch
Cardiac hypertrophy and altered beta-adrenergic signaling in transgenic mice that express the amino terminus of beta-ARK1.
American journal of physiology. Heart and circulatory physiology 2003;285(5):H2201-11.
2003: Burns C Blaxall; Rainer Spang; Howard A Rockman; Walter J Koch
Differential myocardial gene expression in the development and rescue of murine heart failure.
Physiological genomics 2003;15(2):105-14.
2003: Cyrus J Parsa; Akio Matsumoto; Jihee Kim; Ryan U Riel; Laura S Pascal; G Brant Walton; Richard B Thompson; Jason A Petrofski; Brian H Annex; Jonathan S Stamler; Walter J Koch
A novel protective effect of erythropoietin in the infarcted heart.
The Journal of clinical investigation 2003;112(7):999-1007.
2003: Jason A Petrofski; Walter J Koch
The beta-adrenergic receptor kinase in heart failure.
Journal of molecular and cellular cardiology 2003;35(10):1167-74.
2003: David J Nusz; David C White; Qunsheng Dai; Anne M Pippen; Michael A Thompson; G Brant Walton; Cyrus J Parsa; Walter J Koch; Brian H Annex
Vascular rarefaction in peripheral skeletal muscle after experimental heart failure.
American journal of physiology. Heart and circulatory physiology 2003;285(4):H1554-62.
2003: Angela L Bookout; Amanda E Finney; Rishu Guo; Karsten Peppel; Walter J Koch; Yehia A Daaka
Targeting Gbetagamma signaling to inhibit prostate tumor formation and growth.
The Journal of biological chemistry 2003;278(39):37569-73.
2003: Patrick Most; Andrew Remppis; Sven T Pleger; Eva Löffler; Philipp Ehlermann; Juliane Bernotat; Christiane Kleuss; Jörg Heierhorst; Patricia Ruiz; Henning Witt; Peter Karczewski; Lan Mao; Howard A Rockman; Sandra J Duncan; Hugo A Katus; Walter J Koch
Transgenic overexpression of the Ca2+-binding protein S100A1 in the heart leads to increased in vivo myocardial contractile performance.
The Journal of biological chemistry 2003;278(36):33809-17.
2003: Jonathan A Hata; Walter J Koch
Phosphorylation of G protein-coupled receptors: GPCR kinases in heart disease.
Molecular interventions 2003;3(5):264-72.
2003: Sitaram M Emani; Ashish S Shah; Michael K Bowman; Sitaramesh Emani; Katrina Wilson; Donald D Glower; Walter J Koch
Catheter-based intracoronary myocardial adenoviral gene delivery: importance of intraluminal seal and infusion flow rate.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;8(2):306-13.
2003: Patrick Most; Walter J Koch
Sealing the leak, healing the heart.
Nature medicine 2003;9(8):993-4.
2003: Kamran Baig; Ryan C Fields; Jeffrey G Gaca; Steven I Hanish; Luther G Milton; Walter J Koch; Jeffrey H Lawson
A porcine model of intimal-medial hyperplasia in polytetrafluoroethylene arteriovenous grafts.
The journal of vascular access 2003;4(3):111-7.
2003: Cyrus J Parsa; Walter J Koch
Gene interventions in the beta-adrenergic system for treating heart failure.
Seminars in thoracic and cardiovascular surgery 2003;15(3):259-67.
2003: Burns C Blaxall; Bryn M Tschannen-Moran; Carmelo A Milano; Walter J Koch
Differential gene expression and genomic patient stratification following left ventricular assist device support.
Journal of the American College of Cardiology 2003;41(7):1096-106.
2003: guido iaccarino; Walter J Koch
Transgenic mice targeting the heart unveil G protein-coupled receptor kinases as therapeutic targets.
Assay and drug development technologies 2003;1(2):347-55.
2003: Thomas Rau; Monika Nose; Ute Remmers; Joachim Weil; Astrid Weissmüller; Kerry Davia; Sian Harding; Karsten Peppel; Walter J Koch; Thomas Eschenhagen
Overexpression of wild-type Galpha(i)-2 suppresses beta-adrenergic signaling in cardiac myocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(3):523-5.
2003: David T Lucas; Prafulla Aryal; Luke I Szweda; Walter J Koch; Leslie A Leinwand
Alterations in mitochondrial function in a mouse model of hypertrophic cardiomyopathy.
American journal of physiology. Heart and circulatory physiology 2003;284(2):H575-83.
2003: Hendrik T Tevaearai; Walter J Koch
Modification of in vivo cardiac performance by intracoronary gene transfer of beta-adrenergic receptor signaling components.
Methods in molecular biology (Clifton, N.J.) 2003;219():219-32.
2002: Walter J Koch
Gene transfer of beta-adrenergic signaling components for heart failure.
Journal of cardiac failure 2002;8(6 Suppl):S526-31.
2002: Hendrik T Tevaearai; G Brant Walton; Andrea D Eckhart; Janelle R Keys; Walter J Koch
Heterotopic transplantation as a model to study functional recovery of unloaded failing hearts.
The Journal of thoracic and cardiovascular surgery 2002;124(6):1149-56.
2002: Hendrik T Tevaearai; G Brant Walton; Andrea D Eckhart; Janelle R Keys; Walter J Koch
Donor heart contractile dysfunction following prolonged ex vivo preservation can be prevented by gene-mediated beta-adrenergic signaling modulation.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2002;22(5):733-7.
2002: Janelle R Keys; Emily A Greene; Walter J Koch; Andrea D Eckhart
Gq-coupled receptor agonists mediate cardiac hypertrophy via the vasculature.
Hypertension 2002;40(5):660-6.
2002: Jihee Kim; Andrea D Eckhart; Satoru Eguchi; Walter J Koch
Beta-adrenergic receptor-mediated DNA synthesis in cardiac fibroblasts is dependent on transactivation of the epidermal growth factor receptor and subsequent activation of extracellular signal-regulated kinases.
The Journal of biological chemistry 2002;277(35):32116-23.
2002: David S Feldman; A Musa Zamah; Kristen L Pierce; William E Miller; Francine Kelly; Antonio Rapacciuolo; Howard A Rockman; Walter J Koch; Louis M Luttrell
Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus.
The Journal of biological chemistry 2002;277(32):28631-40.
2002: guido iaccarino; Ersilia Cipolletta; Andrea Fiorillo; Mario Annecchiarico; Michele Ciccarelli; Vincenzo Cimini; Walter J Koch; Bruno Trimarco
Beta(2)-adrenergic receptor gene delivery to the endothelium corrects impaired adrenergic vasorelaxation in hypertension.
Circulation 2002;106(3):349-55.
2002: Hendrik T Tevaearai; Andrea D Eckhart; G Brant Walton; Janelle R Keys; Katrina Wilson; Walter J Koch
Myocardial gene transfer and overexpression of beta2-adrenergic receptors potentiates the functional recovery of unloaded failing hearts.
Circulation 2002;106(1):124-9.
2002: Tiziana Cogliati; Deborah J Good; Mark Haigney; Petra Delgado-Romero; Michael Eckhaus; Walter J Koch; Ilan R Kirsch
Predisposition to arrhythmia and autonomic dysfunction in Nhlh1-deficient mice.
Molecular and cellular biology 2002;22(14):4977-83.
2002: Andrea D Eckhart; Richard C Fentzke; John J Lepore; Roberto Lang; Hua Lin; Robert J Lefkowitz; Walter J Koch; Jeffrey M Leiden
Inhibition of betaARK1 restores impaired biochemical beta-adrenergic receptor responsiveness but does not rescue CREB(A133) induced cardiomyopathy.
Journal of molecular and cellular cardiology 2002;34(6):669-77.
2002: Haibin Gong; Hong Sun; Walter J Koch; Thomas Rau; Thomas Eschenhagen; Ursula Ravens; Jürgen F Heubach; Dawn L Adamson; Sian E Harding
Specific beta(2)AR blocker ICI 118,551 actively decreases contraction through a G(i)-coupled form of the beta(2)AR in myocytes from failing human heart.
Circulation 2002;105(21):2497-503.
2002: J Mark Jones; Kenneth H Wilson; Walter J Koch; Carmelo A Milano
Adenoviral gene transfer to the heart during cardiopulmonary bypass: effect of myocardial protection technique on transgene expression.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2002;21(5):847-52.
2002: Andrea D Eckhart; Tohru Ozaki; Hendrik T Tevaearai; Howard A Rockman; Walter J Koch
Vascular-targeted overexpression of G protein-coupled receptor kinase-2 in transgenic mice attenuates beta-adrenergic receptor signaling and increases resting blood pressure.
Molecular pharmacology 2002;61(4):749-58.
2002: Hendrik T Tevaearai; G Brant Walton; Walter J Koch
[Gene therapy and benefits in modulating of system beta-adrenergic in cardiac insufficiency].
Revue médicale de la Suisse romande 2002;122(3):149-53.
2002: Heather R Cross; Elizabeth Murphy; Walter J Koch; CHARLES STEENBERGEN
Male and female mice overexpressing the beta(2)-adrenergic receptor exhibit differences in ischemia/reperfusion injury: role of nitric oxide.
Cardiovascular research 2002;53(3):662-71.
2002: Howard A Rockman; Walter J Koch; Robert J Lefkowitz
Seven-transmembrane-spanning receptors and heart function.
Nature 2002;415(6868):206-12.
2002: Andrew Remppis; Patrick Most; Eva Löffler; Philipp Ehlermann; Juliane Bernotat; Sven T Pleger; Melanie Börries; Michael Reppel; Joachim Fischer; Walter J Koch; Godfrey Smith; Hugo A Katus
The small EF-hand Ca2+ binding protein S100A1 increases contractility and Ca2+ cycling in rat cardiac myocytes.
Basic research in cardiology 2002;97 Suppl 1():I56-62.
2002: Andrea D Eckhart; Walter J Koch
Expression of a beta-adrenergic receptor kinase inhibitor reverses dysfunction in failing cardiomyocytes.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(1):74-9.
2002: Giovanni Esposito; Antonio Rapacciuolo; Sathyamangla V Naga Prasad; Hideyuki Takaoka; Steven A Thomas; Walter J Koch; Howard A Rockman
Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress.
Circulation 2002;105(1):85-92.
2001: H T Tevaearai; Andrea D Eckhart; Walter J Koch
Gene-mediated inhibition of the b-adrenergic receptor kinase: a new therapeutic strategy for heart failure.
Minerva cardioangiologica 2001;49(6):389-94.
2001: Patrick Most; Juliane Bernotat; Philipp Ehlermann; Sven T Pleger; Michael Reppel; M Börries; F Niroomand; B Pieske; Paul Janssen; Thomas Eschenhagen; P Karczewski; Godfrey L Smith; Walter J Koch; Hugo A Katus; Andrew Remppis
S100A1: a regulator of myocardial contractility.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13889-94.
2001: Sitaram M Emani; Ashish S Shah; David C White; Donald D Glower; Walter J Koch
Right ventricular gene therapy with a beta-adrenergic receptor kinase inhibitor improves survival after pulmonary artery banding.
The Annals of thoracic surgery 2001;72(5):1657-61.
2001: Hendrik T Tevaearai; Andrea D Eckhart; KF Shotwell; Katrina Wilson; Walter J Koch
Ventricular dysfunction after cardioplegic arrest is improved after myocardial gene transfer of a beta-adrenergic receptor kinase inhibitor.
Circulation 2001;104(17):2069-74.
2001: Andrea D Eckhart; Walter J Koch
Transgenic studies of cardiac adrenergic receptor regulation.
The Journal of pharmacology and experimental therapeutics 2001;299(1):1-5.
2001: M J Davidson; Walter J Koch
Genetic manipulation of beta-adrenergic signalling in heart failure.
Acta physiologica Scandinavica 2001;173(1):145-50.
2001: guido iaccarino; Emanuele Barbato; E Cipolleta; A Esposito; Andrea Fiorillo; Walter J Koch; Bruno Trimarco
Cardiac betaARK1 upregulation induced by chronic salt deprivation in rats.
Hypertension 2001;38(2):255-60.
2001: guido iaccarino; Janelle R Keys; Antonio Rapacciuolo; KF Shotwell; Robert J Lefkowitz; Howard A Rockman; Walter J Koch
Regulation of myocardial betaARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing alpha1B-adrenergic receptors.
Journal of the American College of Cardiology 2001;38(2):534-40.
2001: M J Davidson; J Mark Jones; Sitaram M Emani; Kenneth H Wilson; James Jaggers; Walter J Koch; Carmelo A Milano
Cardiac gene delivery with cardiopulmonary bypass.
Circulation 2001;104(2):131-3.
2001: V B Harding; L R Jones; Robert J Lefkowitz; Walter J Koch; Howard A Rockman
Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(10):5809-14.
2001: EP Chen; Hartmuth B Bittner; SA Akhter; Walter J Koch; R Duane Davis
Myocardial function in hearts with transgenic overexpression of the G protein-coupled receptor kinase 5.
The Annals of thoracic surgery 2001;71(4):1320-4.
2001: K Freeman; I Lerman; E G Kranias; T Bohlmeyer; M R Bristow; R J Lefkowitz; guido iaccarino; Walter J Koch; Leslie A Leinwand
Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy.
The Journal of clinical investigation 2001;107(8):967-74.
2001: Giovanni Esposito; Sathyamangla V Naga Prasad; Antonio Rapacciuolo; Lan Mao; Walter J Koch; Howard A Rockman
Cardiac overexpression of a G(q) inhibitor blocks induction of extracellular signal-regulated kinase and c-Jun NH(2)-terminal kinase activity in in vivo pressure overload.
Circulation 2001;103(10):1453-8.
2001: Ashish S Shah; David C White; Sitaram M Emani; Alan P Kypson; R Eric Lilly; Katrina Wilson; Donald D Glower; Robert J Lefkowitz; Walter J Koch
In vivo ventricular gene delivery of a beta-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction.
Circulation 2001;103(9):1311-6.
2001: Mohamed A Gaballa; A Eckhart; Walter J Koch; Steven Goldman
Vascular beta-adrenergic receptor system is dysfunctional after myocardial infarction.
American journal of physiology. Heart and circulatory physiology 2001;280(3):H1129-35.
2001: Wei-Zhong Zhu; Ming Zheng; Walter J Koch; RJ Lefkowitz; Brian K Kobilka; Rui-Ping Xiao
Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1607-12.
2001: D C White; Walter J Koch
Myocardial gene transfer.
Current cardiology reports 2001;3(1):37-42.
2001: K Freeman; C Colon-Rivera; M Charlotte Olsson; Russell L Moore; H D Weinberger; I L Grupp; Karen Lynn Vikstrom; guido iaccarino; Walter J Koch; Leslie A Leinwand
Progression from hypertrophic to dilated cardiomyopathy in mice that express a mutant myosin transgene.
American journal of physiology. Heart and circulatory physiology 2001;280(1):H151-9.
2000: B S Manning; KF Shotwell; Lan Mao; Howard A Rockman; Walter J Koch
Physiological induction of a beta-adrenergic receptor kinase inhibitor transgene preserves ss-adrenergic responsiveness in pressure-overload cardiac hypertrophy.
Circulation 2000;102(22):2751-7.
2000: Haibin Gong; Dawn L Adamson; Hardeep K Ranu; Walter J Koch; Jürgen F Heubach; Ursula Ravens; O Zolk; Sian E Harding
The effect of Gi-protein inactivation on basal, and beta(1)- and beta(2)AR-stimulated contraction of myocytes from transgenic mice overexpressing the beta(2)-adrenoceptor.
British journal of pharmacology 2000;131(3):594-600.
2000: Mohamed A Gaballa; A D Eckhart; Walter J Koch; Steven Goldman
Vascular beta-adrenergic receptor adenylyl cyclase system in maturation and aging.
Journal of molecular and cellular cardiology 2000;32(9):1745-55.
2000: Ashish S Shah; David C White; O Tai; Jonathan A Hata; Kenneth H Wilson; Anne M Pippen; Alan P Kypson; Donald D Glower; Robert J Lefkowitz; Walter J Koch
Adenovirus-mediated genetic manipulation of the myocardial beta-adrenergic signaling system in transplanted hearts.
The Journal of thoracic and cardiovascular surgery 2000;120(3):581-8.
2000: Ashish S Shah; B Zane Atkins; Jonathan A Hata; O Tai; Alan P Kypson; R Eric Lilly; Walter J Koch; Donald D Glower
Early effects of right ventricular volume overload on ventricular performance and beta-adrenergic signaling.
The Journal of thoracic and cardiovascular surgery 2000;120(2):342-9.
2000: Sheng-Jun Zhang; Heping Cheng; Ying-Ying Zhou; D J Wang; Weizhong Zhu; Bruce D Ziman; H Spurgoen; RJ Lefkowitz; Edward G Lakatta; Walter J Koch; Rui-Ping Xiao
Inhibition of spontaneous beta 2-adrenergic activation rescues beta 1-adrenergic contractile response in cardiomyocytes overexpressing beta 2-adrenoceptor.
The Journal of biological chemistry 2000;275(28):21773-9.
2000: David C White; Jonathan A Hata; Ashish S Shah; Donald D Glower; Robert J Lefkowitz; Walter J Koch
Preservation of myocardial beta-adrenergic receptor signaling delays the development of heart failure after myocardial infarction.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5428-33.
2000: R J Lefkowitz; H A Rockman; Walter J Koch
Catecholamines, cardiac beta-adrenergic receptors, and heart failure.
Circulation 2000;101(14):1634-7.
2000: Sathyamangla V Naga Prasad; Giovanni Esposito; Lan Mao; Walter J Koch; Howard A Rockman
Gbetagamma-dependent phosphoinositide 3-kinase activation in hearts with in vivo pressure overload hypertrophy.
The Journal of biological chemistry 2000;275(7):4693-8.
2000: Ashish S Shah; R Eric Lilly; Alan P Kypson; O Tai; Jonathan A Hata; Anne M Pippen; Scott Silvestry; Robert J Lefkowitz; Donald D Glower; Walter J Koch
Intracoronary adenovirus-mediated delivery and overexpression of the beta(2)-adrenergic receptor in the heart : prospects for molecular ventricular assistance.
Circulation 2000;101(4):408-14.
2000: Andrea D Eckhart; S J Duncan; Raymond B Penn; J L Benovic; Robert J Lefkowitz; Walter J Koch
Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart.
Circulation research 2000;86(1):43-50.
2000: Walter J Koch; Robert J Lefkowitz; Howard A Rockman
Functional consequences of altering myocardial adrenergic receptor signaling.
Annual review of physiology 2000;62():237-60.
1999: Heather R Cross; CHARLES STEENBERGEN; R J Lefkowitz; Walter J Koch; Elizabeth Murphy
Overexpression of the cardiac beta(2)-adrenergic receptor and expression of a beta-adrenergic receptor kinase-1 (betaARK1) inhibitor both increase myocardial contractility but have differential effects on susceptibility to ischemic injury.
Circulation research 1999;85(11):1077-84.
1999: guido iaccarino; Walter J Koch
G beta gamma-mediated signaling: new therapeutic target for proliferative vascular disease.
IUBMB life 1999;48(3):257-61.
1999: guido iaccarino; Robert J Lefkowitz; Walter J Koch
Myocardial G protein-coupled receptor kinases: implications for heart failure therapy.
Proceedings of the Association of American Physicians 1999;111(5):399-405.
1999: JP Maurice; Walter J Koch
Potential future therapies for heart failure: gene transfer of beta-adrenergic signaling components.
Coronary artery disease 1999;10(6):401-5.
1999: SA Akhter; Andrea D Eckhart; Howard A Rockman; KF Shotwell; Robert J Lefkowitz; Walter J Koch
In vivo inhibition of elevated myocardial beta-adrenergic receptor kinase activity in hybrid transgenic mice restores normal beta-adrenergic signaling and function.
Circulation 1999;100(6):648-53.
1999: M C Cho; Antonio Rapacciuolo; Walter J Koch; Y Kobayashi; L R Jones; Howard A Rockman
Defective beta-adrenergic receptor signaling precedes the development of dilated cardiomyopathy in transgenic mice with calsequestrin overexpression.
The Journal of biological chemistry 1999;274(32):22251-6.
1999: Tam T T Huynh; guido iaccarino; MG Davies; H J Safi; Walter J Koch; Per-Otto Hagen
External support modulates G protein expression and receptor coupling in experimental vein grafts.
Surgery 1999;126(2):127-34.
1999: Alan P Kypson; SC Hendrickson; SA Akhter; Katrina Wilson; P McDonald; R Eric Lilly; Paul C Dolber; Donald D Glower; Robert J Lefkowitz; Walter J Koch
Adenovirus-mediated gene transfer of the beta2-adrenergic receptor to donor hearts enhances cardiac function.
Gene therapy 1999;6(7):1298-304.
1999: JP Maurice; Jonathan A Hata; Ashish S Shah; David C White; Patricia McDonald; Paul C Dolber; Kenneth H Wilson; Robert J Lefkowitz; Donald D Glower; Walter J Koch
Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta2-adrenergic receptor gene delivery.
The Journal of clinical investigation 1999;104(1):21-9.
1999: JP Maurice; Ashish S Shah; Alan P Kypson; Jonathan A Hata; David C White; Donald D Glower; Walter J Koch
Molecular beta-adrenergic signaling abnormalities in failing rabbit hearts after infarction.
The American journal of physiology 1999;276(6 Pt 2):H1853-60.
1999: Gerald W Dorn; NM Tepe; John N Lorenz; Walter J Koch; Stephen B Liggett
Low- and high-level transgenic expression of beta2-adrenergic receptors differentially affect cardiac hypertrophy and function in Galphaq-overexpressing mice.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(11):6400-5.
1999: M C Cho; M Rao; Walter J Koch; S A Thomas; R D Palmiter; Howard A Rockman
Enhanced contractility and decreased beta-adrenergic receptor kinase-1 in mice lacking endogenous norepinephrine and epinephrine.
Circulation 1999;99(20):2702-7.
1999: guido iaccarino; Walter J Koch
Therapeutic potential of G-protein coupled receptor kinases in the heart.
Expert opinion on investigational drugs 1999;8(5):545-54.
1999: Walter J Koch; Howard A Rockman
Exploring the role of the beta-adrenergic receptor kinase in cardiac disease using gene-targeted mice.
Trends in cardiovascular medicine 1999;9(3-4):77-81.
1999: Jürgen F Heubach; I Trebess; Erich Wettwer; Herbert M Himmel; Martin C Michel; Alberto J Kaumann; Walter J Koch; Sian E Harding; Ursula Ravens
L-type calcium current and contractility in ventricular myocytes from mice overexpressing the cardiac beta 2-adrenoceptor.
Cardiovascular research 1999;42(1):173-82.
1999: EP Chen; SA Akhter; Hartmuth B Bittner; Walter J Koch; R Duane Davis; P Van Trigt
Molecular and functional mechanisms of right ventricular adaptation in chronic pulmonary hypertension.
The Annals of thoracic surgery 1999;67(4):1053-8.
1999: R An; BM Heath; J P Higgins; Walter J Koch; R J Lefkowitz; Robert Kass
Beta2-adrenergic receptor overexpression in the developing mouse heart: evidence for targeted modulation of ion channels.
The Journal of physiology 1999;516 ( Pt 1)():19-30.
1999: guido iaccarino; L A Smithwick; Robert J Lefkowitz; Walter J Koch
Targeting Gbeta gamma signaling in arterial vascular smooth muscle proliferation: a novel strategy to limit restenosis.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3945-50.
1999: JL Zeiders; Frederic J Seidler; guido iaccarino; Walter J Koch; Theodore A Slotkin
Ontogeny of cardiac beta-adrenoceptor desensitization mechanisms: agonist treatment enhances receptor/G-protein transduction rather than eliciting uncoupling.
Journal of molecular and cellular cardiology 1999;31(2):413-23.
1999: Rui-Ping Xiao; Pavel Avdonin; Ying-Ying Zhou; Heping Cheng; S A Akhter; T Eschenhagen; RJ Lefkowitz; Walter J Koch; Edward G Lakatta
Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes.
Circulation research 1999;84(1):43-52.
1999: K M Anderson; A D Eckhart; R N Willette; Walter J Koch
The myocardial beta-adrenergic system in spontaneously hypertensive heart failure (SHHF) rats.
Hypertension 1999;33(1 Pt 2):402-7.
1999: guido iaccarino; Paul C Dolber; Robert J Lefkowitz; Walter J Koch
Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation.
Hypertension 1999;33(1 Pt 2):396-401.
1998: EP Chen; Hartmuth B Bittner; SA Akhter; Walter J Koch; R Duane Davis
Myocardial recovery after ischemia and reperfusion injury is significantly impaired in hearts with transgenic overexpression of beta-adrenergic receptor kinase.
Circulation 1998;98(19 Suppl):II249-53; discussion II253-4.
1998: guido iaccarino; E D Tomhave; Robert J Lefkowitz; Walter J Koch
Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade.
Circulation 1998;98(17):1783-9.
1998: guido iaccarino; Howard A Rockman; KF Shotwell; E D Tomhave; Walter J Koch
Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs.
The American journal of physiology 1998;275(4 Pt 2):H1298-306.
1998: MG Davies; Tam T T Huynh; GJ Fulton; Robert J Lefkowitz; E Svendsen; Per-Otto Hagen; Walter J Koch
G protein signaling and vein graft intimal hyperplasia: reduction of intimal hyperplasia in vein grafts by a Gbetagamma inhibitor suggests a major role of G protein signaling in lesion development.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(8):1275-80.
1998: Tam T T Huynh; guido iaccarino; MG Davies; E Svendsen; Walter J Koch; Per-Otto Hagen
Adenoviral-mediated inhibition of G beta gamma signaling limits the hyperplastic response in experimental vein grafts.
Surgery 1998;124(2):177-86.
1998: Howard A Rockman; DJ Choi; S A Akhter; M Jaber; Bruno GIROS; Robert J Lefkowitz; Marc G Caron; Walter J Koch
Control of myocardial contractile function by the level of beta-adrenergic receptor kinase 1 in gene-targeted mice.
The Journal of biological chemistry 1998;273(29):18180-4.
1998: Howard A Rockman; Kenneth R Chien; DJ Choi; guido iaccarino; JJ Hunter; John Ross; Robert J Lefkowitz; Walter J Koch
Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):7000-5.
1998: M A Gaballa; Karsten Peppel; Robert J Lefkowitz; M Aguirre; Paul C Dolber; G D Pennock; Walter J Koch; S Goldman
Enhanced vasorelaxation by overexpression of beta 2-adrenergic receptors in large arteries.
Journal of molecular and cellular cardiology 1998;30(5):1037-45.
1998: SA Akhter; Louis M Luttrell; Howard A Rockman; guido iaccarino; Robert J Lefkowitz; Walter J Koch
Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy.
Science (New York, N.Y.) 1998;280(5363):574-7.
1998: Rui-Ping Xiao; E D Tomhave; D J Wang; X Ji; Marvin O Boluyt; Heping Cheng; Edward G Lakatta; Walter J Koch
Age-associated reductions in cardiac beta1- and beta2-adrenergic responses without changes in inhibitory G proteins or receptor kinases.
The Journal of clinical investigation 1998;101(6):1273-82.
1998: Alan P Kypson; Karsten Peppel; SA Akhter; R Eric Lilly; Donald D Glower; Robert J Lefkowitz; Walter J Koch
Ex vivo adenovirus-mediated gene transfer to the adult rat heart.
The Journal of thoracic and cardiovascular surgery 1998;115(3):623-30.
1998: Walter J Koch; Robert J Lefkowitz; Carmelo A Milano; SA Akhter; Howard A Rockman
Myocardial overexpression of adrenergic receptors and receptor kinases.
Advances in pharmacology (San Diego, Calif.) 1998;42():502-6.
1997: SA Akhter; C A Skaer; Alan P Kypson; Patricia McDonald; Karsten Peppel; Donald D Glower; Robert J Lefkowitz; Walter J Koch
Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(22):12100-5.
1997: SA Akhter; Carmelo A Milano; KF Shotwell; M C Cho; Howard A Rockman; Robert J Lefkowitz; Walter J Koch
Transgenic mice with cardiac overexpression of alpha1B-adrenergic receptors. In vivo alpha1-adrenergic receptor-mediated regulation of beta-adrenergic signaling.
The Journal of biological chemistry 1997;272(34):21253-9.
1997: DJ Choi; Walter J Koch; JJ Hunter; Howard A Rockman
Mechanism of beta-adrenergic receptor desensitization in cardiac hypertrophy is increased beta-adrenergic receptor kinase.
The Journal of biological chemistry 1997;272(27):17223-9.
1997: Karsten Peppel; Walter J Koch; R J Lefkowitz
Gene transfer strategies for augmenting cardiac function.
Trends in cardiovascular medicine 1997;7(5):145-50.
1997: M H Drazner; Walter J Koch; Robert J Lefkowitz
Potentiation of beta-adrenergic signaling by gene transfer.
Proceedings of the Association of American Physicians 1997;109(3):220-7.
1997: Howard A Rockman; Walter J Koch; R J Lefkowitz
Cardiac function in genetically engineered mice with altered adrenergic receptor signaling.
The American journal of physiology 1997;272(4 Pt 2):H1553-9.
1997: GJ Fulton; MG Davies; Walter J Koch; H Dalen; E Svendsen; Per-Otto Hagen
Antisense oligonucleotide to proto-oncogene c-myb inhibits the formation of intimal hyperplasia in experimental vein grafts.
Journal of vascular surgery 1997;25(3):453-63.
1997: M H Drazner; Karsten Peppel; S Dyer; Augustus O Grant; Walter J Koch; Robert J Lefkowitz
Potentiation of beta-adrenergic signaling by adenoviral-mediated gene transfer in adult rabbit ventricular myocytes.
The Journal of clinical investigation 1997;99(2):288-96.
1997: Louis M Luttrell; T van Biesen; B E Hawes; Walter J Koch; KM Krueger; K Touhara; Robert J Lefkowitz
G-protein-coupled receptors and their regulation: activation of the MAP kinase signaling pathway by G-protein-coupled receptors.
Advances in second messenger and phosphoprotein research 1997;31():263-77.
1997: D H Korzick; Rui-Ping Xiao; Bruce D Ziman; Walter J Koch; RJ Lefkowitz; Edward G Lakatta
Transgenic manipulation of beta-adrenergic receptor kinase modifies cardiac myocyte contraction to norepinephrine.
The American journal of physiology 1997;272(1 Pt 2):H590-6.
1996: G Lembo; Howard A Rockman; JJ Hunter; H Steinmetz; Walter J Koch; L Ma; M P Prinz; John Ross; Kenneth R Chien; L Powell-Braxton
Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency.
The Journal of clinical investigation 1996;98(11):2648-55.
1996: Ghassan Jaber; Walter J Koch; Howard A Rockman; Bradley R Smith; Richard A Bond; Kathleen K Sulik; J Ross; R J Lefkowitz; Marc G Caron; Bruno GIROS
Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(23):12974-9.
1996: Julie A Pitcher; Z L Fredericks; W C Stone; Richard T Premont; RH Stoffel; Walter J Koch; R J Lefkowitz
Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies.
The Journal of biological chemistry 1996;271(40):24907-13.
1996: Howard A Rockman; DJ Choi; N U Rahman; SA Akhter; R J Lefkowitz; Walter J Koch
Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(18):9954-9.
1996: Howard A Rockman; Walter J Koch; Carmelo A Milano; R J Lefkowitz
Myocardial beta-adrenergic receptor signaling in vivo: insights from transgenic mice.
Journal of molecular medicine (Berlin, Germany) 1996;74(9):489-95.
1996: Walter J Koch; C A Milano; R J Lefkowitz
Transgenic manipulation of myocardial G protein-coupled receptors and receptor kinases.
Circulation research 1996;78(4):511-6.
1996: T van Biesen; B E Hawes; John R Raymond; Louis M Luttrell; Walter J Koch; R J Lefkowitz
G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism.
The Journal of biological chemistry 1996;271(3):1266-9.
1995: Stephen S G Ferguson; L Ménard; Larry S Barak; Walter J Koch; A M Colapietro; Marc G Caron
Role of phosphorylation in agonist-promoted beta 2-adrenergic receptor sequestration. Rescue of a sequestration-defective mutant receptor by beta ARK1.
The Journal of biological chemistry 1995;270(42):24782-9.
1995: B E Hawes; T van Biesen; Walter J Koch; Louis M Luttrell; R J Lefkowitz
Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation.
The Journal of biological chemistry 1995;270(29):17148-53.
1995: K Touhara; Walter J Koch; B E Hawes; R J Lefkowitz
Mutational analysis of the pleckstrin homology domain of the beta-adrenergic receptor kinase. Differential effects on G beta gamma and phosphatidylinositol 4,5-bisphosphate binding.
The Journal of biological chemistry 1995;270(28):17000-5.
1995: Louis M Luttrell; T van Biesen; B E Hawes; Walter J Koch; K Touhara; R J Lefkowitz
G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor.
The Journal of biological chemistry 1995;270(28):16495-8.
1995: Louis M Luttrell; B E Hawes; K Touhara; T van Biesen; Walter J Koch; R J Lefkowitz
Effect of cellular expression of pleckstrin homology domains on Gi-coupled receptor signaling.
The Journal of biological chemistry 1995;270(22):12984-9.
1995: Walter J Koch; Howard A Rockman; P Samama; R A Hamilton; Richard A Bond; Carmelo A Milano; R J Lefkowitz
Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor.
Science (New York, N.Y.) 1995;268(5215):1350-3.
1995: L A Nair; James Inglese; RH Stoffel; Walter J Koch; R J Lefkowitz; Madan M Kwatra; Augustus O Grant
Cardiac muscarinic potassium channel activity is attenuated by inhibitors of G beta gamma.
Circulation research 1995;76(5):832-8.
1995: James Inglese; Walter J Koch; K Touhara; R J Lefkowitz
G beta gamma interactions with PH domains and Ras-MAPK signaling pathways.
Trends in biochemical sciences 1995;20(4):151-6.
1994: Walter J Koch; B E Hawes; L F Allen; R J Lefkowitz
Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(26):12706-10.
1994: James Inglese; Louis M Luttrell; Jorge A Iniguez-Lluhi; K Touhara; Walter J Koch; R J Lefkowitz
Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(9):3637-41.
1994: Richard T Premont; Walter J Koch; James Inglese; R J Lefkowitz
Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases.
The Journal of biological chemistry 1994;269(9):6832-41.
1994: Walter J Koch; B E Hawes; James Inglese; Louis M Luttrell; R J Lefkowitz
Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling.
The Journal of biological chemistry 1994;269(8):6193-7.
1994: K Ishii; J Chen; M Ishii; Walter J Koch; N J Freedman; R J Lefkowitz; Shaun R Coughlin
Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases.
The Journal of biological chemistry 1994;269(2):1125-30.
1994: Ingrid Boekhoff; James Inglese; S Schleicher; Walter J Koch; R J Lefkowitz; Heinz Breer
Olfactory desensitization requires membrane targeting of receptor kinase mediated by beta gamma-subunits of heterotrimeric G proteins.
The Journal of biological chemistry 1994;269(1):37-40.
1993: James Inglese; N J Freedman; Walter J Koch; R J Lefkowitz
Structure and mechanism of the G protein-coupled receptor kinases.
The Journal of biological chemistry 1993;268(32):23735-8.
1993: Walter J Koch; James Inglese; W C Stone; R J Lefkowitz
The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase.
The Journal of biological chemistry 1993;268(11):8256-60.
1993: R J Lefkowitz; S Cotecchia; M A Kjelsberg; Julie A Pitcher; Walter J Koch; James Inglese; Marc G Caron
Adrenergic receptors: recent insights into their mechanism of activation and desensitization.
Advances in second messenger and phosphoprotein research 1993;28():1-9.
1992: James Inglese; Walter J Koch; Marc G Caron; R J Lefkowitz
Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases.
Nature 1992;359(6391):147-50.
1992: R J Diebold; Walter J Koch; P T Ellinor; J J Wang; Mariappan Muthuchamy; David F Wieczorek; Arnold Schwartz
Mutually exclusive exon splicing of the cardiac calcium channel alpha 1 subunit gene generates developmentally regulated isoforms in the rat heart.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(4):1497-501.
1992: K Itagaki; Walter J Koch; Ilona Bodi; Udo Klöckner; D F Slish; Arnold Schwartz
Native-type DHP-sensitive calcium channel currents are produced by cloned rat aortic smooth muscle and cardiac alpha 1 subunits expressed in Xenopus laevis oocytes and are regulated by alpha 2- and beta-subunits.
FEBS letters 1992;297(3):221-5.
1992: R J Lefkowitz; James Inglese; Walter J Koch; Julie A Pitcher; H Attramadal; Marc G Caron
G-protein-coupled receptors: regulatory role of receptor kinases and arrestin proteins.
Cold Spring Harbor symposia on quantitative biology 1992;57():127-33.
1991: Manfred Grabner; K Friedrich; Hans-Günther Knaus; Jörg Striessnig; F Scheffauer; R Staudinger; Walter J Koch; A Schwartz; Hartmut Glossmann
Calcium channels from Cyprinus carpio skeletal muscle.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(3):727-31.
1987: J S Williams; Y H Baik; Walter J Koch; A Schwartz
A possible role for the endothelium in porcine coronary smooth muscle responses to dihydropyridine calcium channel modulators.
The Journal of pharmacology and experimental therapeutics 1987;241(2):379-86.