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Stefan Kochanek

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Chemicals & Drugs

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Conrad Weber; Nicole Armbruster; Stefan Kochanek; Florian Kreppel; Axel Rethwilm; Carsten Scheller; Andre F Steinert
Foamy virus-adenovirus hybrid vectors for gene therapy of the arthritides.
Yvonne Genzel; Stefan Kochanek; Claudia Kueppers; Erdmann Rapp; Jana Rödig; Gudrun Schiedner; Ilona Behrendt; Udo Reichl
CAP, a new human suspension cell line for influenza virus production.
Yoshiaki Sunami; Sebastian Wissel; Bernd Baumann; Sigrid Espenlaub; Katja Fiedler; Sarah Gul; Nurdan Güldiken; Nora Hipp; Karl-Heinz Holzmann; Stefan Kochanek; Florian Kreppel; Frank Leithäuser; Tom Luedde; Karin Scharffetter-Kochanek; Marion Schneider; Anca Sindrilaru; Pavel Strnad; Thomas Wirth
Hepatic activation of IKK/NFκB signaling induces liver fibrosis via macrophage-mediated chronic inflammation.

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2013: Conrad Weber; Nicole Armbruster; Stefan Kochanek; Florian Kreppel; Axel Rethwilm; Carsten Scheller; Andre F Steinert
Foamy virus-adenovirus hybrid vectors for gene therapy of the arthritides.
The journal of gene medicine 2013;15(3-4):155-67.
2013: Yvonne Genzel; Stefan Kochanek; Claudia Kueppers; Erdmann Rapp; Jana Rödig; Gudrun Schiedner; Ilona Behrendt; Udo Reichl
CAP, a new human suspension cell line for influenza virus production.
Applied microbiology and biotechnology 2013;97(1):111-22.
2012: Yoshiaki Sunami; Sebastian Wissel; Bernd Baumann; Sigrid Espenlaub; Katja Fiedler; Sarah Gul; Nurdan Güldiken; Nora Hipp; Karl-Heinz Holzmann; Stefan Kochanek; Florian Kreppel; Frank Leithäuser; Tom Luedde; Karin Scharffetter-Kochanek; Marion Schneider; Anca Sindrilaru; Pavel Strnad; Thomas Wirth
Hepatic activation of IKK/NFκB signaling induces liver fibrosis via macrophage-mediated chronic inflammation.
Hepatology (Baltimore, Md.) 2012;56(3):1117-28.
2012: Xiaomin Dong; Stefan Kochanek; Katrin S Lindenberg; Anke Witting; Shan Zong; Bin Huang
Adenovirus vector-based in vitro neuronal cell model for Huntington's disease with human disease-like differential aggregation and degeneration.
The journal of gene medicine 2012;14(7):468-81.
2012: Johanna P Laakkonen; Ignacio A Romero; Babette Weksler; Pierre-Olivier Couraud; Tatjana Engler; Florian Kreppel; Stefan Kochanek
Transcellular targeting of fiber- and hexon-modified adenovirus vectors across the brain microvascular endothelial cells in vitro.
PloS one 2012;7(9):e45977.
2011: Matthias W Kron; Reinhold Schirmbeck; Erika Schmidt; Tatjana Engler; Stefan Kochanek; Florian Kreppel
High-capacity adenoviral vectors circumvent the limitations of ΔE1 and ΔE1/ΔE3 adenovirus vectors to induce multispecific transgene product-directed CD8 T-cell responses.
The journal of gene medicine 2011;13(12):648-57.
2011: Shan Zong; Matthias W Kron; Hermann Bujard; Tatjana Engler; Christian Epp; Stefan Kochanek; Florian Kreppel
ΔE1 and high-capacity adenoviral vectors expressing full-length codon-optimized merozoite surface protein 1 for vaccination against Plasmodium falciparum.
The journal of gene medicine 2011;13(12):670-9.
2011: Nicolai Treiber; Pallab Maity; Karmveer Singh; Matthias Kohn; Alexander F Keist; Florentina Ferchiu; Lea Sante; Sebastian Frese; Wilhelm Bloch; Florian Kreppel; Stefan Kochanek; Anca Sindrilaru; Sebastian Iben; Josef Högel; M Ohnmacht; Lutz E Claes; Anita Ignatius; Jin H Chung; Min J Lee; York Kamenisch; Mark Berneburg; Thorsten Nikolaus; Kerstin Braunstein; Anne-Dorte Sperfeld; Albert C Ludolph; Karlis Briviba; Meinhard Wlaschek; Peter Angel; Lore Florin; Karin Scharffetter-Kochanek
Accelerated aging phenotype in mice with conditional deficiency for mitochondrial superoxide dismutase in the connective tissue.
Aging cell 2011;10(2):239-54.
2011: Nancy Larochelle; Rolf Stucka; Norman Rieger; Lothar Schermelleh; Gudrun Schiedner; Stefan Kochanek; Eckhard Wolf; Hanns Lochmüller
Genomic integration of adenoviral gene transfer vectors following transduction of fertilized mouse oocytes.
Transgenic research 2011;20(1):123-35.
2011: Jan-Michael Prill; Sigrid Espenlaub; Ulrike Samen; Tatjana Engler; Erika Schmidt; Francesco Vetrini; Amanda Rosewell; Nathan Grove; Donna Palmer; Philip Ng; Stefan Kochanek; Florian Kreppel
Modifications of adenovirus hexon allow for either hepatocyte detargeting or targeting with potential evasion from Kupffer cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(1):83-92.
2010: Ana Carina Silva; Cristina Peixoto; Tanja Lucas; Claudia Küppers; Pedro E Cruz; Paula M Alves; Stefan Kochanek
Adenovirus vector production and purification.
Current gene therapy 2010;10(6):437-55.
2010: Sam Laurel Stephen; Eugenio Montini; Vijayshankar Ganesh Sivanandam; Muhseen Al-Dhalimy; Hans A Kestler; Milton Finegold; Markus Grompe; Stefan Kochanek
Chromosomal integration of adenoviral vector DNA in vivo.
Journal of virology 2010;84(19):9987-94.
2010: Sigrid Espenlaub; Stephanie Corjon; Tatjana Engler; Carolin Fella; Manfred Ogris; Ernst Wagner; Stefan Kochanek; Florian Kreppel
Capsomer-specific fluorescent labeling of adenoviral vector particles allows for detailed analysis of intracellular particle trafficking and the performance of bioresponsive bonds for vector capsid modifications.
Human gene therapy 2010;21(9):1155-67.
2010: Stefan Kochanek; Bernd Gansbacher
Prostate cancer gene therapy: attempts to innovate.
Human gene therapy 2010;21(7):791.
2009: Nicolai Treiber; Thorsten Peters; Anca Sindrilaru; Roman Huber; Matthias Kohn; Andre Menke; Karlis Briviba; Florian Kreppel; Abhijit Basu; Pallab Maity; Mandy Koller; Sebastian Iben; Meinhard Wlaschek; Stefan Kochanek; Karin Scharffetter-Kochanek
Overexpression of manganese superoxide dismutase in human dermal fibroblasts enhances the contraction of free floating collagen lattice: implications for ageing and hyperplastic scar formation.
Archives of dermatological research 2009;301(4):273-87.
2008: Sigrid Espenlaub; Andreas Wortmann; Tatjana Engler; Stephanie Corjon; Stefan Kochanek; Florian Kreppel
Reductive amination as a strategy to reduce adenovirus vector promiscuity by chemical capsid modification with large polysaccharides.
The journal of gene medicine 2008;10(12):1303-14.
2008: Sam Laurel Stephen; Vijayshankar Ganesh Sivanandam; Stefan Kochanek
Homologous and heterologous recombination between adenovirus vector DNA and chromosomal DNA.
The journal of gene medicine 2008;10(11):1176-89.
2008: Stephanie Corjon; Andreas Wortmann; Tatjana Engler; Nico van Rooijen; Stefan Kochanek; Florian Kreppel
Targeting of adenovirus vectors to the LRP receptor family with the high-affinity ligand RAP via combined genetic and chemical modification of the pIX capsomere.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(11):1813-24.
2008: Vijayshankar Ganesh Sivanandam; Sam Laurel Stephen; Ruben Hernandez-Alcoceba; Pilar Alzuguren; Maider Zabala; Nico van Rooijen; Cheng Qian; Irina Berger; Marie-Luise Gross; Jesus Prieto; Stefan Kochanek
Lethality in an anti-angiogenic tumor gene therapy model upon constitutive but not inducible expression of the soluble vascular endothelial growth factor receptor 1.
The journal of gene medicine 2008;10(10):1083-91.
2008: Reinhold Schirmbeck; Jörg Reimann; Stefan Kochanek; Florian Kreppel
The immunogenicity of adenovirus vectors limits the multispecificity of CD8 T-cell responses to vector-encoded transgenic antigens.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(9):1609-16.
2008: Andreas Wieland; Markus Denzel; Erika Schmidt; Stefan Kochanek; Florian Kreppel; Jörg Reimann; Reinhold Schirmbeck
Recombinant complexes of antigen with stress proteins are potent CD8 T-cell-stimulating immunogens.
Journal of molecular medicine (Berlin, Germany) 2008;86(9):1067-79.
2008: Bin Huang; Johannes Schiefer; Christian Sass; Christoph M Kosinski; Stefan Kochanek
Inducing huntingtin inclusion formation in primary neuronal cell culture and in vivo by high-capacity adenoviral vectors expressing truncated and full-length huntingtin with polyglutamine expansion.
The journal of gene medicine 2008;10(3):269-79.
2008: M Reboredo; Maider Zabala; I Mauleon; Javier De Las Rivas; Florian Kreppel; Stefan Kochanek; Jesús Prieto; Ruben Hernandez-Alcoceba; M Gabriela Kramer
Interleukin-12 inhibits liver-specific drug-inducible systems in vivo.
Gene therapy 2008;15(4):277-88.
2008: Florian Kreppel; Stefan Kochanek
Modification of adenovirus gene transfer vectors with synthetic polymers: a scientific review and technical guide.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(1):16-29.
2008: Andreas Wortmann; Sabine Vöhringer; Tatjana Engler; Stephanie Corjon; Reinhold Schirmbeck; Jörg Reimann; Stefan Kochanek; Florian Kreppel
Fully detargeted polyethylene glycol-coated adenovirus vectors are potent genetic vaccines and escape from pre-existing anti-adenovirus antibodies.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(1):154-62.
2007: Sylvie Julien; Norbert Kociok; Florian Kreppel; Jürgen Kopitz; Stefan Kochanek; Antje Biesemeier; Petra Blitgen-Heinecke; Peter Heiduschka; Ulrich Schraermeyer
Tyrosinase biosynthesis and trafficking in adult human retinal pigment epithelial cells.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie 2007;245(10):1495-505.
2007: Bin Huang; Johannes Schiefer; Christian Sass; G Bernhard Landwehrmeyer; Christoph M Kosinski; Stefan Kochanek
High-capacity adenoviral vector-mediated reduction of huntingtin aggregate load in vitro and in vivo.
Human gene therapy 2007;18(4):303-11.
2006: Stefan Arnhold; Peter Heiduschka; Helmut Klein; Yvonne Absenger; Serkan Basnaoglu; Florian Kreppel; Sigrid Henke-Fahle; Stefan Kochanek; Karl Ulrich Bartz-Schmidt; Klaus Addicks; Ulrich Schraermeyer
Adenovirally transduced bone marrow stromal cells differentiate into pigment epithelial cells and induce rescue effects in RCS rats.
Investigative ophthalmology & visual science 2006;47(9):4121-9.
2006: Christian Thirion; Hanns Lochmüller; Zsolt Ruzsics; Marc Boelhauve; Cornelia König; Cornelia Thedieck; Stephan Kutik; Christiane Geiger; Stefan Kochanek; Christoph Volpers; Hans-Gerhard Burgert
Adenovirus vectors based on human adenovirus type 19a have high potential for human muscle-directed gene therapy.
Human gene therapy 2006;17(2):193-205.
2005: Florian Kreppel; Judith Gackowski; Erika Schmidt; Stefan Kochanek
Combined genetic and chemical capsid modifications enable flexible and efficient de- and retargeting of adenovirus vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(1):107-17.
2005: Bin Huang; Stefan Kochanek
Adenovirus-mediated silencing of huntingtin expression by shRNA.
Human gene therapy 2005;16(5):618-26.
2005: Roberto Bilbao; Daniel P Reay; E Wu; H Zheng; Volker Biermann; Stefan Kochanek; Paula R Clemens
Comparison of high-capacity and first-generation adenoviral vector gene delivery to murine muscle in utero.
Gene therapy 2005;12(1):39-47.
2004: Zhilong Jiang; Gudrun Schiedner; Nico van Rooijen; Chau-Ching Liu; Stefan Kochanek; Paula R Clemens
Sustained muscle expression of dystrophin from a high-capacity adenoviral vector with systemic gene transfer of T cell costimulatory blockade.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;10(4):688-96.
2004: Zhilong Jiang; Gudrun Schiedner; S C Gilchrist; Stefan Kochanek; Paula R Clemens
CTLA4Ig delivered by high-capacity adenoviral vector induces stable expression of dystrophin in mdx mouse muscle.
Gene therapy 2004;11(19):1453-61.
2004: Stefan Arnhold; Irina Semkova; Christian Andressen; Doris Lenartz; G Meissner; Volker Sturm; Stefan Kochanek; Klaus Addicks; Ulrich Schraermeyer
Iris pigment epithelial cells: a possible cell source for the future treatment of neurodegenerative diseases.
Experimental neurology 2004;187(2):410-7.
2004: Marcus Picard-Maureau; Florian Kreppel; Dirk Lindemann; Thomas Juretzek; Ottmar Herchenröder; Axel Rethwilm; Stefan Kochanek; Martin Heinkelein
Foamy virus--adenovirus hybrid vectors.
Gene therapy 2004;11(8):722-8.
2004: Christoph Volpers; Stefan Kochanek
Adenoviral vectors for gene transfer and therapy.
The journal of gene medicine 2004;6 Suppl 1():S164-71.
2004: Andrea Tuettenberg; Helmut Jonuleit; Thomas Tüting; Jürgen Brück; Volker Biermann; Stefan Kochanek; Jürgen Knop; Alexander H Enk
Early adenoviral gene expression mediates immunosuppression by transduced dendritic cell (DC): implications for immunotherapy using genetically modified DC.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(3):1524-30.
2004: Florian Kreppel; Stefan Kochanek
Long-term transgene expression in proliferating cells mediated by episomally maintained high-capacity adenovirus vectors.
Journal of virology 2004;78(1):9-22.
2003: Gudrun Schiedner; Wilhelm Bloch; Sabine Hertel; Marion Johnston; Andrei Molojavyi; Volker Dries; Georg Varga; Nico van Rooijen; Stefan Kochanek
A hemodynamic response to intravenous adenovirus vector particles is caused by systemic Kupffer cell-mediated activation of endothelial cells.
Human gene therapy 2003;14(17):1631-41.
2003: Roberto Bilbao; Daniel P Reay; T Hughes; Volker Biermann; Christoph Volpers; L Goldberg; J Bergelson; Stefan Kochanek; Paula R Clemens
Fetal muscle gene transfer is not enhanced by an RGD capsid modification to high-capacity adenoviral vectors.
Gene therapy 2003;10(21):1821-9.
2003: Marinee K L Chuah; Gudrun Schiedner; Lieven Thorrez; Brian Brown; Marion Johnston; Veerle Gillijns; Sabine Hertel; Nico van Rooijen; David Lillicrap; Désiré Collen; Thierry VandenDriessche; Stefan Kochanek
Therapeutic factor VIII levels and negligible toxicity in mouse and dog models of hemophilia A following gene therapy with high-capacity adenoviral vectors.
Blood 2003;101(5):1734-43.
2003: Christoph Volpers; Christian Thirion; Volker Biermann; Stefanie Hussmann; Helmut Kewes; Patrick Dunant; Helga von der Mark; Andreas Herrmann; Stefan Kochanek; Hanns Lochmüller
Antibody-mediated targeting of an adenovirus vector modified to contain a synthetic immunoglobulin g-binding domain in the capsid.
Journal of virology 2003;77(3):2093-104.
2003: Stefan Arnhold; M Hilgers; Doris Lenartz; Irina Semkova; Stefan Kochanek; Jürgen Voges; Christian Andressen; Klaus Addicks
Neural precursor cells as carriers for a gene therapeutical approach in tumor therapy.
Cell transplantation 2003;12(8):827-37.
2003: Gudrun Schiedner; Sabine Hertel; Marion Johnston; Volker Dries; Nico van Rooijen; Stefan Kochanek
Selective depletion or blockade of Kupffer cells leads to enhanced and prolonged hepatic transgene expression using high-capacity adenoviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;7(1):35-43.
2002: Irina Semkova; Florian Kreppel; Gerhard Welsandt; Thomas T Luther; Jolanta Kozlowski; Hanna Janicki; Stefan Kochanek; Ulrich Schraermeyer
Autologous transplantation of genetically modified iris pigment epithelial cells: a promising concept for the treatment of age-related macular degeneration and other disorders of the eye.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(20):13090-5.
2002: Christian Thirion; Nancy Larochelle; Christoph Volpers; Patrick Dunant; Rolf Stucka; Paul Holland; Josephine Nalbantoglu; Stefan Kochanek; Hanns Lochmüller
Strategies for muscle-specific targeting of adenoviral gene transfer vectors.
Neuromuscular disorders : NMD 2002;12 Suppl 1():S30-9.
2002: Zhilong Jiang; Eleanor Feingold; Stefan Kochanek; Paula R Clemens
Systemic delivery of a high-capacity adenoviral vector expressing mouse CTLA4Ig improves skeletal muscle gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(3):369-76.
2002: Soyoung C Gilchrist; Martin P Ontell; Stefan Kochanek; Paula R Clemens
Immune response to full-length dystrophin delivered to Dmd muscle by a high-capacity adenoviral vector.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(3):359-68.
2002: Robert Dinser; Frank Zaucke; Florian Kreppel; Kjell Hultenby; Stefan Kochanek; Mats Paulsson; Patrik Maurer
Pseudoachondroplasia is caused through both intra- and extracellular pathogenic pathways.
The Journal of clinical investigation 2002;110(4):505-13.
2002: Florian Kreppel; Volker Biermann; Stefan Kochanek; Gudrun Schiedner
A DNA-based method to assay total and infectious particle contents and helper virus contamination in high-capacity adenoviral vector preparations.
Human gene therapy 2002;13(10):1151-6.
2002: Michael Badorf; Frank Edenhofer; Volker Dries; Stefan Kochanek; Gudrun Schiedner
Efficient in vitro and in vivo excision of floxed sequences with a high-capacity adenoviral vector expressing Cre recombinase.
Genesis (New York, N.Y. : 2000) 2002;33(3):119-24.
2002: Florian Kreppel; Thomas T Luther; Irina Semkova; Ulrich Schraermeyer; Stefan Kochanek
Long-term transgene expression in the RPE after gene transfer with a high-capacity adenoviral vector.
Investigative ophthalmology & visual science 2002;43(6):1965-70.
2002: Gudrun Schiedner; Sabine Hertel; Marion Johnston; Volker Biermann; Volker Dries; Stefan Kochanek
Variables affecting in vivo performance of high-capacity adenovirus vectors.
Journal of virology 2002;76(4):1600-9.
2002: Stefan Arnhold; Florian Kreppel; S Kandirali; Doris Lenartz; Franz-Josef Klinz; Volker Sturm; Stefan Kochanek; Christian Andressen; Klaus Addicks
Intracerebral transplantation and successful integration of astrocytes following genetic modification with a high-capacity adenoviral vector.
Cell transplantation 2002;11(7):663-70.
2001: Stefan Kochanek; Gudrun Schiedner; Christoph Volpers
High-capacity 'gutless' adenoviral vectors.
Current opinion in molecular therapeutics 2001;3(5):454-63.
2001: Volker Biermann; Christoph Volpers; S Hussmann; A Stock; H Kewes; Gudrun Schiedner; A Herrmann; Stefan Kochanek
Targeting of high-capacity adenoviral vectors.
Human gene therapy 2001;12(14):1757-69.
2001: Robert Dinser; Florian Kreppel; Frank Zaucke; C Blank; Mats Paulsson; Stefan Kochanek; Patrik Maurer
Comparison of long-term transgene expression after non-viral and adenoviral gene transfer into primary articular chondrocytes.
Histochemistry and cell biology 2001;116(1):69-77.
2001: Z L Jiang; Daniel P Reay; Florian Kreppel; Andrea Gambotto; Eleanor Feingold; Stefan Kochanek; Susan A McCarthy; Paula R Clemens
Local high-capacity adenovirus-mediated mCTLA4Ig and mCD40Ig expression prolongs recombinant gene expression in skeletal muscle.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;3(6):892-900.
2001: Clare E Thomas; Gudrun Schiedner; Stefan Kochanek; Maria G Castro; Pedro R Lowenstein
Preexisting antiadenoviral immunity is not a barrier to efficient and stable transduction of the brain, mediated by novel high-capacity adenovirus vectors.
Human gene therapy 2001;12(7):839-46.
2000: Gudrun Schiedner; Sabine Hertel; Stefan Kochanek
Efficient transformation of primary human amniocytes by E1 functions of Ad5: generation of new cell lines for adenoviral vector production.
Human gene therapy 2000;11(15):2105-16.
2000: Clare E Thomas; Gudrun Schiedner; Stefan Kochanek; Maria G Castro; Pedro R Löwenstein
Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: toward realistic long-term neurological gene therapy for chronic diseases.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(13):7482-7.
2000: Wanda O Neal; Heshan Zhou; Núria Morral; Claire Langston; RJ Parks; FL Graham; Stefan Kochanek; Arthur L Beaudet
Toxicity associated with repeated administration of first-generation adenovirus vectors does not occur with a helper-dependent vector.
Molecular medicine (Cambridge, Mass.) 2000;6(3):179-95.
1999: Núria Morral; Wanda O Neal; Karen Rice; M Michelle Leland; J Kaplan; Pedro Piedra; Heshan Zhou; RJ Parks; R Velji; Estuardo Aguilar-Córdova; S Wadsworth; FL Graham; Stefan Kochanek; K Dee Carey; Arthur L Beaudet
Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(22):12816-21.
1999: Stefan Kochanek
High-capacity adenoviral vectors for gene transfer and somatic gene therapy.
Human gene therapy 1999;10(15):2451-9.
1999: Stefan Kochanek
Development of high-capacity adenoviral vectors for gene therapy.
Thrombosis and haemostasis 1999;82(2):547-51.
1999: Lucio Pastore; Núria Morral; Heshan Zhou; R Garcia; RJ Parks; Stefan Kochanek; FL Graham; Brendan Lee; Arthur L Beaudet
Use of a liver-specific promoter reduces immune response to the transgene in adenoviral vectors.
Human gene therapy 1999;10(11):1773-81.
1999: H H Chen; L M Mack; S Y Choi; Martin P Ontell; Stefan Kochanek; Paula R Clemens
DNA from both high-capacity and first-generation adenoviral vectors remains intact in skeletal muscle.
Human gene therapy 1999;10(3):365-73.
1999: Mark M Burcin; Gudrun Schiedner; Stefan Kochanek; Sophia Y Tsai; Bert W O'Malley
Adenovirus-mediated regulable target gene expression in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(2):355-60.
1998: Núria Morral; RJ Parks; Heshan Zhou; Claire Langston; Gudrun Schiedner; J Quinones; FL Graham; Stefan Kochanek; Arthur L Beaudet
High doses of a helper-dependent adenoviral vector yield supraphysiological levels of alpha1-antitrypsin with negligible toxicity.
Human gene therapy 1998;9(18):2709-16.
1998: MA Morsy; M Gu; Sherri L Motzel; J Zhao; J Lin; Qin Su; H Allen; Laura L Franlin; RJ Parks; FL Graham; Stefan Kochanek; Andrew J Bett; CT Caskey
An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(14):7866-71.
1998: Gudrun Schiedner; Núria Morral; RJ Parks; Ying Wu; S C Koopmans; Claire Langston; FL Graham; Arthur L Beaudet; Stefan Kochanek
Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity.
Nature genetics 1998;18(2):180-3.
1998: SS Floyd; Paula R Clemens; M R Ontell; Stefan Kochanek; Charles S Day; J Yang; S D Hauschka; L Balkir; J Morgan; Morey S Moreland; G W Feero; Michael W Epperly; Johnny Huard
Ex vivo gene transfer using adenovirus-mediated full-length dystrophin delivery to dystrophic muscles.
Gene therapy 1998;5(1):19-30.
1997: H H Chen; L M Mack; R Kelly; Martin P Ontell; Stefan Kochanek; Paula R Clemens
Persistence in muscle of an adenoviral vector that lacks all viral genes.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):1645-50.
1997: William G. Feero; J David Rosenblatt; Johnny Huard; simon simon watkins; Michael W Epperly; Paula R Clemens; Stefan Kochanek; Joseph C Glorioso; Terence A Partridge; Eric Hoffman
Viral gene delivery to skeletal muscle: insights on maturation-dependent loss of fiber infectivity for adenovirus and herpes simplex type 1 viral vectors.
Human gene therapy 1997;8(4):371-80.
1996: Paula R Clemens; Stefan Kochanek; Y Sunada; S Chan; H H Chen; K P Campbell; CT Caskey
In vivo muscle gene transfer of full-length dystrophin with an adenoviral vector that lacks all viral genes.
Gene therapy 1996;3(11):965-72.
1996: Stefan Kochanek; K Hosokawa; Gudrun Schiedner; D Renz; Walter Doerfler
DNA methylation in the promoter of ribosomal RNA genes in human cells as determined by genomic sequencing.
FEBS letters 1996;388(2-3):192-4.
1996: Stefan Kochanek; Paula R Clemens; K Mitani; H H Chen; S Chan; CT Caskey
A new adenoviral vector: Replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and beta-galactosidase.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(12):5731-6.
1995: K Mitani; FL Graham; CT Caskey; Stefan Kochanek
Rescue, propagation, and partial purification of a helper virus-dependent adenovirus vector.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(9):3854-8.
1995: Stefan Kochanek; D Renz; Walter Doerfler
Transcriptional silencing of human Alu sequences and inhibition of protein binding in the box B regulatory elements by 5'-CG-3' methylation.
FEBS letters 1995;360(2):115-20.
1994: Stefan Kochanek; D Renz; Walter Doerfler
Variability in allelic DNA methylation in spermatozoa.
Human genetics 1994;94(2):203-6.
1993: Stefan Kochanek; D Renz; Walter Doerfler
Differences in the accessibility of methylated and unmethylated DNA to DNase I.
Nucleic acids research 1993;21(25):5843-5.
1993: Stefan Kochanek; D Renz; Walter Doerfler
Probing DNA-protein interactions in vitro with the CpG DNA methyltransferase.
Nucleic acids research 1993;21(10):2339-42.
1993: Stefan Kochanek; D Renz; Walter Doerfler
DNA methylation in the Alu sequences of diploid and haploid primary human cells.
The EMBO journal 1993;12(3):1141-51.
1991: Stefan Kochanek; Andreas Radbruch; Hans Tesch; D Renz; Walter Doerfler
DNA methylation profiles in the human genes for tumor necrosis factors alpha and beta in subpopulations of leukocytes and in leukemias.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(13):5759-63.
1991: R Jüttermann; K Hosokawa; Stefan Kochanek; Walter Doerfler
Adenovirus type 2 VAI RNA transcription by polymerase III is blocked by sequence-specific methylation.
Journal of virology 1991;65(4):1735-42.
1990: Stefan Kochanek; M Toth; A Dehmel; D Renz; Walter Doerfler
Interindividual concordance of methylation profiles in human genes for tumor necrosis factors alpha and beta.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(22):8830-4.
1990: Walter Doerfler; M Toth; Stefan Kochanek; S Achten; U Freisem-Rabien; A Behn-Krappa; G Orend
Eukaryotic DNA methylation: facts and problems.
FEBS letters 1990;268(2):329-33.