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Georg Kochs

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Orthomyxoviridae Infections

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Benjamin Mänz; Roland Zell; Petra Zimmermann; Dominik Dornfeld; Veronika Götz; Otto Haller; Georg Kochs; Martin Schwemmle
Pandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoprotein.
Andreas Pichlmair; Roberto Sacco; Adrijana Stefanovic; Friedemann Weber; Gualtiero Alvisi; Ralf Bartenschlager; Keiryn Bennett; Marco Binder; Andrew G Bowie; Tilmann Bürckstümmer; Jacques Colinge; Carol-Ann Eberle; Astrid Fauster; Adriana Goncalves; Stephen Goodbourn; Matthias Habjan; Cathleen Holze; Kumaran Kandasamy; Georg Kochs; Kristina Lindsten; Orla Mulhern; André C Müller; Giulio Superti-Furga
Viral immune modulators perturb the human molecular network by common and unique strategies.
Iris Koerner; Mikhail N Matrosovich; Peter Staeheli; Otto Haller; Georg Kochs
Altered receptor specificity and fusion activity of the haemagglutinin contribute to high virulence of a mouse-adapted influenza A virus.

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All Publications

2013: Benjamin Mänz; Roland Zell; Petra Zimmermann; Dominik Dornfeld; Veronika Götz; Otto Haller; Georg Kochs; Martin Schwemmle
Pandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoprotein.
PLoS pathogens 2013;9(3):e1003279.
2012: Andreas Pichlmair; Roberto Sacco; Adrijana Stefanovic; Friedemann Weber; Gualtiero Alvisi; Ralf Bartenschlager; Keiryn Bennett; Marco Binder; Andrew G Bowie; Tilmann Bürckstümmer; Jacques Colinge; Carol-Ann Eberle; Astrid Fauster; Adriana Goncalves; Stephen Goodbourn; Matthias Habjan; Cathleen Holze; Kumaran Kandasamy; Georg Kochs; Kristina Lindsten; Orla Mulhern; André C Müller; Giulio Superti-Furga
Viral immune modulators perturb the human molecular network by common and unique strategies.
Nature 2012;487(7408):486-90.
2012: Iris Koerner; Mikhail N Matrosovich; Peter Staeheli; Otto Haller; Georg Kochs
Altered receptor specificity and fusion activity of the haemagglutinin contribute to high virulence of a mouse-adapted influenza A virus.
The Journal of general virology 2012;93(Pt 5):970-9.
2011: Song Gao; Otto Haller; Georg Kochs; Gunnar F Schröder; Alexander von der Malsburg; Alexej Dick; Katja Faelber; Oliver Daumke
Structure of myxovirus resistance protein a reveals intra- and intermolecular domain interactions required for the antiviral function.
Immunity 2011;35(4):514-25.
2011: Alexander von der Malsburg; Inbal Abutbul-Ionita; Otto Haller; Georg Kochs; Dganit Danino
Stalk domain of the dynamin-like MxA GTPase protein mediates membrane binding and liposome tubulation via the unstructured L4 loop.
The Journal of biological chemistry 2011;286(43):37858-65.
2011: Petra Zimmermann; Otto Haller; Benjamin Mänz; Martin Schwemmle; Georg Kochs
The viral nucleoprotein determines Mx sensitivity of influenza A viruses.
Journal of virology 2011;85(16):8133-40.
2011: Nicola Penski; Michael Pfann; Antje Reuter; Dennis Rubbenstroth; Nicolas Ruggli; Benjamin Schusser; Angele Breithaupt; Sandra Gohrbandt; Sonja Härtle; Jana Hundt; Bernd Kaspers; Georg Kochs; Carsten Krohmann; Jürgen Stech; Artur Summerfield; Thomas W Vahlenkamp; Jutta Veits; Peter Staeheli
Highly pathogenic avian influenza viruses do not inhibit interferon synthesis in infected chickens but can override the interferon-induced antiviral state.
Journal of virology 2011;85(15):7730-41.
2011: Marcus Panning; Sigrid Baumgarte; Thomas Laue; Sibylle Bierbaum; Sabine Raith; Jan Felix Drexler; Angelika Helmer; Valeria Falcone-Kapper; Georg Kochs; Hartmut Campe; Daniela Huzly; Anna Maria Eis-Hübinger; Christian Drosten
Singleplex real-time RT-PCR for detection of influenza A virus and simultaneous differentiation of A/H1N1v and evaluation of the RealStar influenza kit.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2011;50(2):171-4.
2011: Otto Haller; Georg Kochs
Human MxA protein: an interferon-induced dynamin-like GTPase with broad antiviral activity.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2011;31(1):79-87.
2010: Sabine Steidle; Luis Martinez-Sobrido; Markus Mordstein; Stefan Lienenklaus; Adolfo García-Sastre; Peter Stäheli; Georg Kochs
Glycine 184 in nonstructural protein NS1 determines the virulence of influenza A virus strain PR8 without affecting the host interferon response.
Journal of virology 2010;84(24):12761-70.
2010: Otto Haller; Song Gao; Alexander von der Malsburg; Oliver Daumke; Georg Kochs
Dynamin-like MxA GTPase: structural insights into oligomerization and implications for antiviral activity.
The Journal of biological chemistry 2010;285(37):28419-24.
2010: Julia Elisabeth Pulverer; Ulfert Rand; Stefan Lienenklaus; Daniela Kugel; Natalia Zietara; Georg Kochs; Ronald Naumann; Siegfried Weiss; Peter Staeheli; Hansjörg Hauser; Mario Köster
Temporal and spatial resolution of type I and III interferon responses in vivo.
Journal of virology 2010;84(17):8626-38.
2010: Markus Mordstein; Eva Neugebauer; Vanessa Ditt; Birthe Jessen; Toni Rieger; Valeria Falcone; Frederic Sorgeloos; Stephan Ehl; Daniel Mayer; Georg Kochs; Martin Schwemmle; Stephan Günther; Christian Drosten; Thomas Michiels; Peter Staeheli
Lambda interferon renders epithelial cells of the respiratory and gastrointestinal tracts resistant to viral infections.
Journal of virology 2010;84(11):5670-7.
2010: Nico Buettner; Carola Vogt; Luis Martinez-Sobrido; Friedemann Weber; Zoe Waibler; Georg Kochs
Thogoto virus ML protein is a potent inhibitor of the interferon regulatory factor-7 transcription factor.
The Journal of general virology 2010;91(Pt 1):220-7.
2009: Georg Kochs; Luis Martinez-Sobrido; Stefan Lienenklaus; Siegfried Weiss; Adolfo García-Sastre; Peter Staeheli
Strong interferon-inducing capacity of a highly virulent variant of influenza A virus strain PR8 with deletions in the NS1 gene.
The Journal of general virology 2009;90(Pt 12):2990-4.
2009: Ariel Rodriguez; Alicia Pérez-González; M Jaber Hossain; Li-Mei Chen; Thierry Rolling; Pilar Pérez-Breña; Ruben Donis; Georg Kochs; Amelia Nieto
Attenuated strains of influenza A viruses do not induce degradation of RNA polymerase II.
Journal of virology 2009;83(21):11166-74.
2009: Thierry Rolling; Iris Koerner; Petra Zimmermann; Kristian Holz; Otto Haller; Peter Staeheli; Georg Kochs
Adaptive mutations resulting in enhanced polymerase activity contribute to high virulence of influenza A virus in mice.
Journal of virology 2009;83(13):6673-80.
2009: Otto Haller; Peter Staeheli; Georg Kochs
Protective role of interferon-induced Mx GTPases against influenza viruses.
Revue scientifique et technique (International Office of Epizootics) 2009;28(1):219-31.
2009: Daniela Kugel; Georg Kochs; Karola Obojes; Joachim Roth; Gary P Kobinger; Darwyn Kobasa; Otto Haller; Peter Staeheli; Veronika von Messling
Intranasal administration of alpha interferon reduces seasonal influenza A virus morbidity in ferrets.
Journal of virology 2009;83(8):3843-51.
2009: Matthias Habjan; Nicola Penski; Valentina Wagner; Martin Spiegel; Anna K Overby; Georg Kochs; Juha Huiskonen; Friedemann Weber
Efficient production of Rift Valley fever virus-like particles: The antiviral protein MxA can inhibit primary transcription of bunyaviruses.
Virology 2009;385(2):400-8.
2008: Carola Vogt; Ellen Preuss; Daniel Mayer; Friedemann Weber; Martin Schwemmle; Georg Kochs
The interferon antagonist ML protein of thogoto virus targets general transcription factor IIB.
Journal of virology 2008;82(22):11446-53.
2008: Jan Dittmann; Silke Stertz; Daniel Grimm; John Steel; Adolfo García-Sastre; Otto Haller; Georg Kochs
Influenza A virus strains differ in sensitivity to the antiviral action of Mx-GTPase.
Journal of virology 2008;82(7):3624-31.
2008: Markus Mordstein; Georg Kochs; Laure Dumoutier; Jean-Christophe Renauld; Søren R Paludan; Kevin Klucher; Peter Staeheli
Interferon-lambda contributes to innate immunity of mice against influenza A virus but not against hepatotropic viruses.
PLoS pathogens 2008;4(9):e1000151.
2007: Otto Haller; Silke Stertz; Georg Kochs
The Mx GTPase family of interferon-induced antiviral proteins.
Microbes and infection / Institut Pasteur 2007;9(14-15):1636-43.
2007: Silke Stertz; Jan Dittmann; Jorge C G Blanco; Lioubov Pletneva; Otto Haller; Georg Kochs
The antiviral potential of interferon-induced cotton rat Mx proteins against orthomyxovirus (influenza), rhabdovirus, and bunyavirus.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2007;27(10):847-55.
2007: Otto Haller; Georg Kochs; Friedemann Weber
Interferon, Mx, and viral countermeasures.
Cytokine & growth factor reviews 2007;18(5-6):425-33.
2007: Alexander Ghanem; Daniel Mayer; Geoffrey Chase; Werner Tegge; Ronald Frank; Georg Kochs; Adolfo García-Sastre; Martin Schwemmle
Peptide-mediated interference with influenza A virus polymerase.
Journal of virology 2007;81(14):7801-4.
2007: Dirk Holzinger; Carl Jorns; Silke Stertz; Stéphanie Boisson-Dupuis; Robert Thimme; Manfred Weidmann; Jean-Laurent Casanova; Otto Haller; Georg Kochs
Induction of MxA gene expression by influenza A virus requires type I or type III interferon signaling.
Journal of virology 2007;81(14):7776-85.
2007: Georg Kochs; Adolfo García-Sastre; Luis Martinez-Sobrido
Multiple anti-interferon actions of the influenza A virus NS1 protein.
Journal of virology 2007;81(13):7011-21.
2007: TS Carlos; D Young; Silke Stertz; Georg Kochs; Richard E Randall
Interferon-induced inhibition of parainfluenza virus type 5; the roles of MxA, PKR and oligo A synthetase/RNase L.
Virology 2007;363(1):166-73.
2007: Otto Haller; Peter Staeheli; Georg Kochs
Interferon-induced Mx proteins in antiviral host defense.
Biochimie 2007;89(6-7):812-8.
2007: Silke Stertz; Mike Reichelt; Martin Spiegel; Thomas Kuri; Luis Martinez-Sobrido; Adolfo García-Sastre; Friedemann Weber; Georg Kochs
The intracellular sites of early replication and budding of SARS-coronavirus.
Virology 2007;361(2):304-15.
2007: Georg Kochs; Iris Koerner; Lena Thiel; Sonja Kothlow; Bernd Kaspers; Nicolas Ruggli; Artur Summerfield; Jovan Pavlovic; Jürgen Stech; Peter Staeheli
Properties of H7N7 influenza A virus strain SC35M lacking interferon antagonist NS1 in mice and chickens.
The Journal of general virology 2007;88(Pt 5):1403-9.
2007: Daniel Grimm; Peter Staeheli; Martin Hufbauer; Iris Koerner; Luis Martinez-Sobrido; Alicia Solórzano; Adolfo García-Sastre; Otto Haller; Georg Kochs
Replication fitness determines high virulence of influenza A virus in mice carrying functional Mx1 resistance gene.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(16):6806-11.
2007: Iris Koerner; Georg Kochs; Ulrich Kalinke; Siegfried Weiss; Peter Staeheli
Protective role of beta interferon in host defense against influenza A virus.
Journal of virology 2007;81(4):2025-30.
2006: Silke Stertz; Mike Reichelt; Jacomine Krijnse-Locker; Jason Mackenzie; Jeremy C Simpson; Otto Haller; Georg Kochs
Interferon-induced, antiviral human MxA protein localizes to a distinct subcompartment of the smooth endoplasmic reticulum.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2006;26(9):650-60.
2006: Otto Haller; Georg Kochs; Friedemann Weber
The interferon response circuit: induction and suppression by pathogenic viruses.
Virology 2006;344(1):119-30.
2006: Carl Jorns; Dirk Holzinger; Robert Thimme; Hans Christian Spangenberg; Manfred Weidmann; Jens Rasenack; Hubert Erich Blum; Otto Haller; Georg Kochs
Rapid and simple detection of IFN-neutralizing antibodies in chronic hepatitis C non-responsive to IFN-alpha.
Journal of medical virology 2006;78(1):74-82.
2005: Stephanie Jennings; Luis Martinez-Sobrido; Adolfo García-Sastre; Friedemann Weber; Georg Kochs
Thogoto virus ML protein suppresses IRF3 function.
Virology 2005;331(1):63-72.
2005: Georg Kochs; Mike Reichelt; Dganit Danino; Jenny E Hinshaw; Otto Haller
Assay and functional analysis of dynamin-like Mx proteins.
Methods in enzymology 2005;404():632-43.
2004: Kathrin Hagmaier; Hans R Gelderblom; Georg Kochs
Functional comparison of the two gene products of Thogoto virus segment 6.
The Journal of general virology 2004;85(Pt 12):3699-708.
2004: Andreas Pichlmair; Johanna Buse; Stephanie Jennings; Otto Haller; Georg Kochs; Peter Staeheli
Thogoto virus lacking interferon-antagonistic protein ML is strongly attenuated in newborn Mx1-positive but not Mx1-negative mice.
Journal of virology 2004;78(20):11422-4.
2004: Mike Reichelt; Silke Stertz; Jacomine Krijnse-Locker; Otto Haller; Georg Kochs
Missorting of LaCrosse virus nucleocapsid protein by the interferon-induced MxA GTPase involves smooth ER membranes.
Traffic (Copenhagen, Denmark) 2004;5(10):772-84.
2004: Friedemann Weber; Georg Kochs; Otto Haller
Inverse interference: how viruses fight the interferon system.
Viral immunology 2004;17(4):498-515.
2003: Gjon Blakqori; Georg Kochs; Otto Haller; Friedemann Weber
Functional L polymerase of La Crosse virus allows in vivo reconstitution of recombinant nucleocapsids.
The Journal of general virology 2003;84(Pt 5):1207-14.
2003: Friedemann Weber; Georg Kochs; Otto Haller; Peter Staeheli
Viral evasion of the interferon system: old viruses, new tricks.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2003;23(4):209-13.
2003: Kathrin Hagmaier; Stephanie Jennings; Johanna Buse; Friedemann Weber; Georg Kochs
Novel gene product of Thogoto virus segment 6 codes for an interferon antagonist.
Journal of virology 2003;77(4):2747-52.
2002: Otto Haller; Georg Kochs
Interferon-induced mx proteins: dynamin-like GTPases with antiviral activity.
Traffic (Copenhagen, Denmark) 2002;3(10):710-7.
2002: Georg Kochs; Markus Haener; Ueli Aebi; Otto Haller
Self-assembly of human MxA GTPase into highly ordered dynamin-like oligomers.
The Journal of biological chemistry 2002;277(16):14172-6.
2002: Georg Kochs; Christian Janzen; Heinz Hohenberg; Otto Haller
Antivirally active MxA protein sequesters La Crosse virus nucleocapsid protein into perinuclear complexes.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):3153-8.
2001: Othmar G Engelhardt; Evelyn Ullrich; Georg Kochs; Otto Haller
Interferon-induced antiviral Mx1 GTPase is associated with components of the SUMO-1 system and promyelocytic leukemia protein nuclear bodies.
Experimental cell research 2001;271(2):286-95.
2001: E Wagner; Othmar G Engelhardt; S Gruber; Otto Haller; Georg Kochs
Rescue of recombinant Thogoto virus from cloned cDNA.
Journal of virology 2001;75(19):9282-6.
2001: Markus Sandrock; Michael Frese; Otto Haller; Georg Kochs
Interferon-induced rat Mx proteins confer resistance to Rift Valley fever virus and other arthropod-borne viruses.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2001;21(9):663-8.
2000: E Wagner; Othmar G Engelhardt; Friedemann Weber; Otto Haller; Georg Kochs
Formation of virus-like particles from cloned cDNAs of Thogoto virus.
The Journal of general virology 2000;81(Pt 12):2849-53.
2000: Georg Kochs; Friedemann Weber; S Gruber; A Delvendahl; C Leitz; Otto Haller
Thogoto virus matrix protein is encoded by a spliced mRNA.
Journal of virology 2000;74(22):10785-9.
2000: Christian Janzen; Georg Kochs; Otto Haller
A monomeric GTPase-negative MxA mutant with antiviral activity.
Journal of virology 2000;74(17):8202-6.
2000: M Trost; Georg Kochs; Otto Haller
Characterization of a novel serine/threonine kinase associated with nuclear bodies.
The Journal of biological chemistry 2000;275(10):7373-7.
2000: Friedemann Weber; Otto Haller; Georg Kochs
MxA GTPase blocks reporter gene expression of reconstituted Thogoto virus ribonucleoprotein complexes.
Journal of virology 2000;74(1):560-3.
1999: F Flohr; S Schneider-Schaulies; Otto Haller; Georg Kochs
The central interactive region of human MxA GTPase is involved in GTPase activation and interaction with viral target structures.
FEBS letters 1999;463(1-2):24-8.
1999: Georg Kochs; Otto Haller
Interferon-induced human MxA GTPase blocks nuclear import of Thogoto virus nucleocapsids.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2082-6.
1999: Georg Kochs; Otto Haller
GTP-bound human MxA protein interacts with the nucleocapsids of Thogoto virus (Orthomyxoviridae).
The Journal of biological chemistry 1999;274(7):4370-6.
1999: Friedemann Weber; S Gruber; Otto Haller; Georg Kochs
PB2 polymerase subunit of Thogoto virus (Orthomyxoviridae family).
Archives of virology 1999;144(8):1601-9.
1998: Friedemann Weber; E Jambrina; S González; JT Dessens; Michael B Leahy; Georg Kochs; Agustín Portela; Patricia A Nuttall; Otto Haller; Juan Ortín; Thomas Zürcher
In vivo reconstitution of active Thogoto virus polymerase: assays for the compatibility with other orthomyxovirus core proteins and template RNAs.
Virus research 1998;58(1-2):13-20.
1998: Friedemann Weber; Georg Kochs; S Gruber; Otto Haller
A classical bipartite nuclear localization signal on Thogoto and influenza A virus nucleoproteins.
Virology 1998;250(1):9-18.
1998: Georg Kochs; M Trost; Christian Janzen; Otto Haller
MxA GTPase: oligomerization and GTP-dependent interaction with viral RNP target structures.
Methods (San Diego, Calif.) 1998;15(3):255-63.
1998: Otto Haller; Michael Frese; Georg Kochs
Mx proteins: mediators of innate resistance to RNA viruses.
Revue scientifique et technique (International Office of Epizootics) 1998;17(1):220-30.
1997: Michael B Leahy; JT Dessens; Friedemann Weber; Georg Kochs; Patricia A Nuttall
The fourth genus in the Orthomyxoviridae: sequence analyses of two Thogoto virus polymerase proteins and comparison with influenza viruses.
Virus research 1997;50(2):215-24.
1997: A Ponten; C Sick; M Weeber; Otto Haller; Georg Kochs
Dominant-negative mutants of human MxA protein: domains in the carboxy-terminal moiety are important for oligomerization and antiviral activity.
Journal of virology 1997;71(4):2591-9.
1997: Friedemann Weber; Otto Haller; Georg Kochs
Conserved vRNA end sequences of Thogoto-orthomyxovirus suggest a new panhandle structure.
Archives of virology 1997;142(5):1029-33.
1996: Friedemann Weber; Otto Haller; Georg Kochs
Nucleoprotein viral RNA and mRNA of Thogoto virus: a novel "cap-stealing" mechanism in tick-borne orthomyxoviruses?
Journal of virology 1996;70(12):8361-7.
1996: Michael Frese; Georg Kochs; H Feldmann; C Hertkorn; Otto Haller
Inhibition of bunyaviruses, phleboviruses, and hantaviruses by human MxA protein.
Journal of virology 1996;70(2):915-23.
1996: J Siebler; Otto Haller; Georg Kochs
Thogoto and Dhori virus replication is blocked by inhibitors of cellular polymerase II activity but does not cause shutoff of host cell protein synthesis.
Archives of virology 1996;141(8):1587-94.
1995: Robert Thimme; Michael Frese; Georg Kochs; Otto Haller
Mx1 but not MxA confers resistance against tick-borne Dhori virus in mice.
Virology 1995;211(1):296-301.
1995: Michael Frese; Georg Kochs; U Meier-Dieter; J Siebler; Otto Haller
Human MxA protein inhibits tick-borne Thogoto virus but not Dhori virus.
Journal of virology 1995;69(6):3904-9.
1995: Otto Haller; Michael Frese; D Rost; Patricia A Nuttall; Georg Kochs
Tick-borne thogoto virus infection in mice is inhibited by the orthomyxovirus resistance gene product Mx1.
Journal of virology 1995;69(4):2596-601.
1993: Georg Kochs; R Hummel; D Meyer; H Hug; Dieter Marmé; T F Sarre
Activation and substrate specificity of the human protein kinase C alpha and zeta isoenzymes.
European journal of biochemistry / FEBS 1993;216(2):597-606.
1993: Walter Kolch; Gisela Heidecker; Georg Kochs; R Hummel; H Vahidi; Mischak Harald; G Finkenzeller; Dieter Marmé; U R Rapp
Protein kinase C alpha activates RAF-1 by direct phosphorylation.
Nature 1993;364(6434):249-52.
1993: Georg Martiny-Baron; Marcelo G Kazanietz; Mischak Harald; Peter M Blumberg; Georg Kochs; H Hug; Dieter Marmé; C Schächtele
Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976.
The Journal of biological chemistry 1993;268(13):9194-7.
1993: Georg Kochs; R Hummel; Bernd L Fiebich; T F Sarre; Dieter Marmé; H Hug
Activation of purified human protein kinase C alpha and beta I isoenzymes in vitro by Ca2+, phosphatidylinositol and phosphatidylinositol 4,5-bisphosphate.
The Biochemical journal 1993;291 ( Pt 2)():627-33.
1993: Bernd L Fiebich; B Jäger; C Schöllmann; Karin Weindel; Jörg Wilting; Georg Kochs; Dieter Marmé; H Hug; Herbert A Weich
Synthesis and assembly of functionally active human vascular endothelial growth factor homodimers in insect cells.
European journal of biochemistry / FEBS 1993;211(1-2):19-26.