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Phillip Koeffler

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
Akagi Tadayuki; Ito Tetsuo; Kato Motohiro; Jin Zhe; Cheng Yulan; Kan Takatsugu; Yamamoto Go; Olaru Alexandru; Kawamata Norihiko; Boult Jessica; Soukiasian Harmik J; Miller Carl W; Ogawa Seishi; Meltzer Stephen J; Koeffler H Phillip
Chromosomal abnormalities and novel disease-related regions in progression from Barrett's esophagus to esophageal adenocarcinoma.
Cao Qi; Gery Sigal; Dashti Azadeh; Yin Dong; Zhou Yan; Gu Jiang; Koeffler H Phillip
A role for the clock gene per1 in prostate cancer.
Nishioka Chie; Ikezoe Takayuki; Yang Jing; Gery Sigal; Koeffler H Phillip; Yokoyama Akihito
Inhibition of mammalian target of rapamycin signaling potentiates the effects of all-trans retinoic acid to induce growth arrest and differentiation of human acute myelogenous leukemia cells.

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All Publications

2009: Akagi Tadayuki; Ito Tetsuo; Kato Motohiro; Jin Zhe; Cheng Yulan; Kan Takatsugu; Yamamoto Go; Olaru Alexandru; Kawamata Norihiko; Boult Jessica; Soukiasian Harmik J; Miller Carl W; Ogawa Seishi; Meltzer Stephen J; Koeffler H Phillip
Chromosomal abnormalities and novel disease-related regions in progression from Barrett's esophagus to esophageal adenocarcinoma.
International journal of cancer. Journal international du cancer 2009;125(10):2349-59.
2009: Cao Qi; Gery Sigal; Dashti Azadeh; Yin Dong; Zhou Yan; Gu Jiang; Koeffler H Phillip
A role for the clock gene per1 in prostate cancer.
Cancer research 2009;69(19):7619-25.
2009: Nishioka Chie; Ikezoe Takayuki; Yang Jing; Gery Sigal; Koeffler H Phillip; Yokoyama Akihito
Inhibition of mammalian target of rapamycin signaling potentiates the effects of all-trans retinoic acid to induce growth arrest and differentiation of human acute myelogenous leukemia cells.
International journal of cancer. Journal international du cancer 2009;125(7):1710-20.
2009: Akagi Tadayuki; Shih Lee-Yung; Ogawa Seishi; Gerss Joachim; Moore Stephen R; Schreck Rhona; Kawamata Norihiko; Liang Der-Cherng; Sanada Masashi; Nannya Yasuhito; Deneberg Stefan; Zachariadis Vasilios; Nordgren Ann; Song Jee Hoon; Dugas Martin; Lehmann Sören; Koeffler H Phillip
Single nucleotide polymorphism genomic arrays analysis of t(8;21) acute myeloid leukemia cells.
Haematologica 2009;94(9):1301-6.
2009: Nishioka Chie; Ikezoe Takayuki; Yang Jing; Komatsu Naoki; Koeffler H Phillip; Yokoyama Akihito
Blockade of MEK signaling potentiates 5-Aza-2'-deoxycytidine-induced apoptosis and upregulation of p21(waf1) in acute myelogenous leukemia cells.
International journal of cancer. Journal international du cancer 2009;125(5):1168-76.
2009: Ikezoe T; Yang J; Nishioka C; Takezaki Y; Tasaka T; Togitani K; Koeffler H P; Yokoyama A
A novel treatment strategy targeting polo-like kinase 1 in hematological malignancies.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2009;23(9):1564-76.
2009: Zang Chuanbing; Liu Hongyu; Bertz Janina; Possinger Kurt; Koeffler H Phillip; Elstner Elena; Eucker Jan
Induction of endoplasmic reticulum stress response by TZD18, a novel dual ligand for peroxisome proliferator-activated receptor alpha/gamma, in human breast cancer cells.
Molecular cancer therapeutics 2009;8(8):2296-307.
2009: Sanada Masashi; Suzuki Takahiro; Shih Lee-Yung; Otsu Makoto; Kato Motohiro; Yamazaki Satoshi; Tamura Azusa; Honda Hiroaki; Sakata-Yanagimoto Mamiko; Kumano Keiki; Oda Hideaki; Yamagata Tetsuya; Takita Junko; Gotoh Noriko; Nakazaki Kumi; Kawamata Norihiko; Onodera Masafumi; Nobuyoshi Masaharu; Hayashi Yasuhide; Harada Hiroshi; Kurokawa Mineo; Chiba Shigeru; Mori Hiraku; Ozawa Keiya; Omine Mitsuhiro; Hirai Hisamaru; Nakauchi Hiromitsu; Koeffler H Phillip; Ogawa Seishi
Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.
Nature 2009;460(7257):904-8.
2009: Kawamata Norihiko; Ogawa Seishi; Gueller Saskia; Ross Samuel H; Huynh Thien; Chen John; Chang Andrew; Nabavi-Nouis Shayan; Megrabian Nairi; Siebert Reiner; Martinez-Climent Jose A; Koeffler H Phillip
Identified hidden genomic changes in mantle cell lymphoma using high-resolution single nucleotide polymorphism genomic array.
Experimental hematology 2009;37(8):937-46.
2009: Thoennissen Nils H; Iwanski Gabriela B; Doan Ngan B; Okamoto Ryoko; Lin Patricia; Abbassi Sam; Song Jee Hoon; Yin Dong; Toh Melvin; Xie Wei Dong; Said Jonathan W; Koeffler H Phillip
Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells.
Cancer research 2009;69(14):5876-84.
2009: Akagi Tadayuki; Yin Dong; Kawamata Norihiko; Bartram Claus R; Hofmann Wolf-K; Song Jee Hoon; Miller Carl W; den Boer Monique L; Koeffler H Phillip
Functional analysis of a novel DNA polymorphism of a tandem repeated sequence in the asparagine synthetase gene in acute lymphoblastic leukemia cells.
Leukemia research 2009;33(7):991-6.
2009: Kawamata Norihiko; Ogawa Seishi; Seeger Karl; Kirschner-Schwabe Renate; Huynh Thien; Chen John; Megrabian Nairi; Harbott Jochen; Zimmermann Martin; Henze Günter; Schrappe Martin; Bartram Claus R; Koeffler H Phillip
Molecular allelokaryotyping of relapsed pediatric acute lymphoblastic leukemia.
International journal of oncology 2009;34(6):1603-12.
2009: Gery Sigal; Cao Qi; Gueller Saskia; Xing Hongtao; Tefferi Ayalew; Koeffler H Phillip
Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F.
Journal of leukocyte biology 2009;85(6):957-65.
2009: Yin Dong; Ogawa Seishi; Kawamata Norihiko; Tunici Patrizia; Finocchiaro Gaetano; Eoli Marica; Ruckert Christian; Huynh Thien; Liu Gentao; Kato Motohiro; Sanada Masashi; Jauch Anna; Dugas Martin; Black Keith L; Koeffler H Phillip
High-resolution genomic copy number profiling of glioblastoma multiforme by single nucleotide polymorphism DNA microarray.
Molecular cancer research : MCR 2009;7(5):665-77.
2009: Gery Sigal; Gueller Saskia; Nowak Verena; Sohn Julia; Hofmann Wolf K; Koeffler H Phillip
Expression of the adaptor protein Lnk in leukemia cells.
Experimental hematology 2009;37(5):585-592.e2.
2009: Nowak Daniel; Le Toriellec Emilie; Stern Marc-Henri; Kawamata Norihiko; Akagi Tadayuki; Dyer Martin J; Hofmann Wolf-Karsten; Ogawa Seishi; Koeffler H Phillip
Molecular allelokaryotyping of T-cell prolymphocytic leukemia cells with high density single nucleotide polymorphism arrays identifies novel common genomic lesions and acquired uniparental disomy.
Haematologica 2009;94(4):518-27.
2009: Nowak Daniel; Stewart Daphne; Koeffler H Phillip
Differentiation therapy of leukemia: 3 decades of development.
Blood 2009;113(16):3655-65.
2009: Kawamata Norihiko; Zhang Ling; Ogawa Seishi; Nannya Yasuhito; Dashti Azadeh; Lu Daning; Lim Stephen; Schreck Rhona; Koeffler H Phillip
Double minute chromosomes containing MYB gene and NUP214-ABL1 fusion gene in T-cell leukemia detected by single nucleotide polymorphism DNA microarray and fluorescence in situ hybridization.
Leukemia research 2009;33(4):569-71.
2009: Akagi Tadayuki; Ogawa Seishi; Dugas Martin; Kawamata Norihiko; Yamamoto Go; Nannya Yasuhito; Sanada Masashi; Miller Carl W; Yung Amanda; Schnittger Susanne; Haferlach Torsten; Haferlach Claudia; Koeffler H Phillip
Frequent genomic abnormalities in acute myeloid leukemia/myelodysplastic syndrome with normal karyotype.
Haematologica 2009;94(2):213-23.
2009: Gombart Adrian F; Bhan Ishir; Borregaard Niels; Tamez Hector; Camargo Carlos A; Koeffler H Phillip; Thadhani Ravi
Low plasma level of cathelicidin antimicrobial peptide (hCAP18) predicts increased infectious disease mortality in patients undergoing hemodialysis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2009;48(4):418-24.
2009: Akagi Tadayuki; Shih Lee-Yung; Kato Motohiro; Kawamata Norihiko; Yamamoto Go; Sanada Masashi; Okamoto Ryoko; Miller Carl W; Liang Der-Cherng; Ogawa Seishi; Koeffler H Phillip
Hidden abnormalities and novel classification of t(15;17) acute promyelocytic leukemia (APL) based on genomic alterations.
Blood 2009;113(8):1741-8.
2009: Gombart Adrian F; Saito Tsuyako; Koeffler H Phillip
Exaptation of an ancient Alu short interspersed element provides a highly conserved vitamin D-mediated innate immune response in humans and primates.
BMC genomics 2009;10():321.
2008: Walsh Christine S; Ogawa Seishi; Scoles Daniel R; Miller Carl W; Kawamata Norihiko; Narod Steven A; Koeffler H Phillip; Karlan Beth Y
Genome-wide loss of heterozygosity and uniparental disomy in BRCA1/2-associated ovarian carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(23):7645-51.
2008: Thant Aye Aye; Wu Yanyuan; Lee Jane; Mishra Dhruva Kumar; Garcia Heather; Koeffler H Phillip; Vadgama Jaydutt V
Role of caspases in 5-FU and selenium-induced growth inhibition of colorectal cancer cells.
Anticancer research 2008;28(6A):3579-92.
2008: Haritunians Talin; Gueller Saskia; O'Kelly James; Ilaria Robert; Koeffler H Phillip
Novel acyl sulfonamide LY573636-sodium: effect on hematopoietic malignant cells.
Oncology reports 2008;20(5):1237-42.
2008: Saito Tsuyako; Okamoto Ryoko; Haritunians Talin; O'Kelly James; Uskokovic Milan; Maehr Hubert; Marczak Stanislaw; Jankowski Pawel; Badr Riem; Koeffler H Phillip
Novel Gemini vitamin D(3) analogs have potent antitumor activity.
The Journal of steroid biochemistry and molecular biology 2008;112(1-3):151-6.
2008: Kawamata Norihiko; Ogawa Seishi; Yamamoto Go; Lehmann Soren; Levine Ross L; Pikman Yana; Nannya Yasuhito; Sanada Masashi; Miller Carl W; Gilliland D Gary; Koeffler H Phillip
Genetic profiling of myeloproliferative disorders by single-nucleotide polymorphism oligonucleotide microarray.
Experimental hematology 2008;36(11):1471-9.
2008: Kawamata Norihiko; Dashti Azadeh; Lu Daning; Miller Becky; Koeffler H Phillip; Schreck Rhona; Moore Stephen; Ogawa Seishi
Chronic phase of ETV6-ABL1 positive CML responds to imatinib.
Genes, chromosomes & cancer 2008;47(10):919-21.
2008: Gueller Saskia; Gery Sigal; Nowak Verena; Liu Liqin; Serve Hubert; Koeffler H Phillip
Adaptor protein Lnk associates with Tyr(568) in c-Kit.
The Biochemical journal 2008;415(2):241-5.
2008: Wakimoto Naoki; Wolf Ido; Yin Dong; O'Kelly James; Akagi Tadayuki; Abramovitz Lilach; Black Keith L; Tai Hsin-Hsiung; Koeffler H Phillip
Nonsteroidal anti-inflammatory drugs suppress glioma via 15-hydroxyprostaglandin dehydrogenase.
Cancer research 2008;68(17):6978-86.
2008: Wakimoto Naoki; Yin Dong; O'Kelly James; Haritunians Talin; Karlan Beth; Said Jonathan; Xing Hongtao; Koeffler H Phillip
Cucurbitacin B has a potent antiproliferative effect on breast cancer cells in vitro and in vivo.
Cancer science 2008;99(9):1793-7.
2008: Yin Dong; Wakimoto Naoki; Xing Hongtao; Lu Daning; Huynh Thien; Wang Xiao; Black Keith L; Koeffler H Phillip
Cucurbitacin B markedly inhibits growth and rapidly affects the cytoskeleton in glioblastoma multiforme.
International journal of cancer. Journal international du cancer 2008;123(6):1364-75.
2008: Haritunians Talin; Gueller Saskia; Zhang Ling; Badr Riem; Yin Dong; Xing Hongtao; Fung Ming Chiu; Koeffler H Phillip
Cucurbitacin B induces differentiation, cell cycle arrest, and actin cytoskeletal alterations in myeloid leukemia cells.
Leukemia research 2008;32(9):1366-73.
2008: Kawamata Norihiko; Ogawa Seishi; Zimmermann Martin; Niebuhr Birte; Stocking Carol; Sanada Masashi; Hemminki Kari; Yamatomo Go; Nannya Yasuhito; Koehler Rolf; Flohr Thomas; Miller Carl W; Harbott Jochen; Ludwig Wolf-Dieter; Stanulla Martin; Schrappe Martin; Bartram Claus R; Koeffler H Phillip
Cloning of genes involved in chromosomal translocations by high-resolution single nucleotide polymorphism genomic microarray.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(33):11921-6.
2008: Lübbert Michael; Müller-Tidow Carsten; Hofmann Wolf-Karsten; Koeffler H Phillip
Advances in the treatment of acute myeloid leukemia: from chromosomal aberrations to biologically targeted therapy.
Journal of cellular biochemistry 2008;104(6):2059-70.
2008: O'Kelly James; Chung Alice; Lemp Nathan; Chumakova Katya; Yin Dong; Wang He-Jing; Said Jonathan; Gui Dorina; Miller Carl W; Karlan Beth Y; Koeffler H Phillip
Functional domains of CCN1 (Cyr61) regulate breast cancer progression.
International journal of oncology 2008;33(1):59-67.
2008: Walsh Christine S; Ogawa Seishi; Karahashi Hisae; Scoles Daniel R; Pavelka James C; Tran Hang; Miller Carl W; Kawamata Norihiko; Ginther Charles; Dering Judy; Sanada Masashi; Nannya Yasuhito; Slamon Dennis J; Koeffler H Phillip; Karlan Beth Y
ERCC5 is a novel biomarker of ovarian cancer prognosis.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(18):2952-8.
2008: Nishioka Chie; Ikezoe Takayuki; Yang Jing; Takeshita Ayako; Taniguchi Ayuko; Komatsu Naoki; Togitani Kazuto; Koeffler H Phillip; Yokoyama Akihito
Blockade of MEK/ERK signaling enhances sunitinib-induced growth inhibition and apoptosis of leukemia cells possessing activating mutations of the FLT3 gene.
Leukemia research 2008;32(6):865-72.
2008: Nishioka Chie; Ikezoe Takayuki; Yang Jing; Miwa Atsushi; Tasaka Taizo; Kuwayama Yoshio; Togitani Kazuto; Koeffler H Phillip; Yokoyama Akihito
Ki11502, a novel multitargeted receptor tyrosine kinase inhibitor, induces growth arrest and apoptosis of human leukemia cells in vitro and in vivo.
Blood 2008;111(10):5086-92.
2008: Lehmann Sören; Ogawa Seishi; Raynaud Sophie D; Sanada Masashi; Nannya Yasuhito; Ticchioni Michel; Bastard Christian; Kawamata Norihiko; Koeffler H Phillip
Molecular allelokaryotyping of early-stage, untreated chronic lymphocytic leukemia.
Cancer 2008;112(6):1296-305.
2008: Akagi Tadayuki; Saitoh Takayuki; O'Kelly James; Akira Shizuo; Gombart Adrian F; Koeffler H Phillip
Impaired response to GM-CSF and G-CSF, and enhanced apoptosis in C/EBPbeta-deficient hematopoietic cells.
Blood 2008;111(6):2999-3004.
2008: Wang Yan; Liu Dongping; Chen Pingping; Koeffler H Phillip; Tong Xiangjun; Xie Dong
Negative feedback regulation of IFN-gamma pathway by IFN regulatory factor 2 in esophageal cancers.
Cancer research 2008;68(4):1136-43.
2008: Nishioka Chie; Ikezoe Takayuki; Yang Jing; Komatsu Naoki; Bandobashi Kentaro; Taniguchi Ayuko; Kuwayama Yoshio; Togitani Kazuto; Koeffler H Phillip; Taguchi Hirokuni
Histone deacetylase inhibitors induce growth arrest and apoptosis of HTLV-1-infected T-cells via blockade of signaling by nuclear factor kappaB.
Leukemia research 2008;32(2):287-96.
2008: Kawamata Norihiko; Ogawa Seishi; Zimmermann Martin; Kato Motohiro; Sanada Masashi; Hemminki Kari; Yamatomo Go; Nannya Yasuhito; Koehler Rolf; Flohr Thomas; Miller Carl W; Harbott Jochen; Ludwig Wolf-Dieter; Stanulla Martin; Schrappe Martin; Bartram Claus R; Koeffler H Phillip
Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide polymorphism oligonucleotide genomic microarray.
Blood 2008;111(2):776-84.
2008: Campbell Moray J; Carlberg Carsten; Koeffler H Phillip
A Role for the PPARgamma in Cancer Therapy.
PPAR research 2008;2008():314974.
2007: Mori Akio; Desmond Julian C; Komatsu Naoki; O'Kelly James; Miller Carl W; Legaspi Ronald; Marchevsky Alberto M; McKenna Robert J; Koeffler H Phillip
CYR61: a new measure of lung cancer outcome.
Cancer investigation 2007;25(8):738-41.
2007: Deng Yue-Zhen; Chen Ping-Ping; Wang Yan; Yin Dong; Koeffler H Phillip; Li Baojie; Tong Xiang-Jun; Xie Dong
Connective tissue growth factor is overexpressed in esophageal squamous cell carcinoma and promotes tumorigenicity through beta-catenin-T-cell factor/Lef signaling.
The Journal of biological chemistry 2007;282(50):36571-81.
2007: Gery S; Virk R K; Chumakov K; Yu A; Koeffler H P
The clock gene Per2 links the circadian system to the estrogen receptor.
Oncogene 2007;26(57):7916-20.
2007: Yin Dong; Kawabata Hiroshi; Tcherniamtchouk Oxana; Huynh Thien; Black Keith L; Koeffler H Phillip
Glioblastoma multiforme cells: expression of erythropoietin receptor and response to erythropoietin.
International journal of oncology 2007;31(5):1193-8.
2007: Gery Sigal; Gueller Saskia; Chumakova Katya; Kawamata Norihiko; Liu Liqin; Koeffler H Phillip
Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders.
Blood 2007;110(9):3360-4.
2007: Kawamata Norihiko; Chen John; Koeffler H Phillip
Suberoylanilide hydroxamic acid (SAHA; vorinostat) suppresses translation of cyclin D1 in mantle cell lymphoma cells.
Blood 2007;110(7):2667-73.
2007: Wolf Ido; Bose Shikha; Desmond Julian C; Lin Bryan T; Williamson Elizabeth A; Karlan Beth Y; Koeffler H Phillip
Unmasking of epigenetically silenced genes reveals DNA promoter methylation and reduced expression of PTCH in breast cancer.
Breast cancer research and treatment 2007;105(2):139-55.
2007: Yang Yang; Ikezoe Takayuki; Zheng Zhixing; Taguchi Hirokuni; Koeffler H Phillip; Zhu Wei-Guo
Saw Palmetto induces growth arrest and apoptosis of androgen-dependent prostate cancer LNCaP cells via inactivation of STAT 3 and androgen receptor signaling.
International journal of oncology 2007;31(3):593-600.
2007: Lehmann S; O'Kelly J; Raynaud S; Funk S E; Sage E H; Koeffler H P
Common deleted genes in the 5q- syndrome: thrombocytopenia and reduced erythroid colony formation in SPARC null mice.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2007;21(9):1931-6.
2007: Yang Jing; Ikezoe Takayuki; Nishioka Chie; Tasaka Taizo; Taniguchi Ayuko; Kuwayama Yoshio; Komatsu Naoki; Bandobashi Kentaro; Togitani Kazuto; Koeffler H Phillip; Taguchi Hirokuni; Yokoyama Akihito
AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo.
Blood 2007;110(6):2034-40.
2007: Garon Edward B; Sawcer David; Vernier P Thomas; Tang Tao; Sun Yinghua; Marcu Laura; Gundersen Martin A; Koeffler H Phillip
In vitro and in vivo evaluation and a case report of intense nanosecond pulsed electric field as a local therapy for human malignancies.
International journal of cancer. Journal international du cancer 2007;121(3):675-82.
2007: Kumagai Takashi; Wakimoto Naoki; Yin Dong; Gery Sigal; Kawamata Norihiko; Takai Noriyuki; Komatsu Naoki; Chumakov Alexy; Imai Yasufumi; Koeffler H Phillip
Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cells.
International journal of cancer. Journal international du cancer 2007;121(3):656-65.
2007: Wang Jingjing; Yong William H; Sun Yinghua; Vernier P Thomas; Koeffler H Phillip; Gundersen Martin A; Marcu Laura
Receptor-targeted quantum dots: fluorescent probes for brain tumor diagnosis.
Journal of biomedical optics 2007;12(4):044021.
2007: Yamamoto Go; Nannya Yasuhito; Kato Motohiro; Sanada Masashi; Levine Ross L; Kawamata Norihiko; Hangaishi Akira; Kurokawa Mineo; Chiba Shigeru; Gilliland D Gary; Koeffler H Phillip; Ogawa Seishi
Highly sensitive method for genomewide detection of allelic composition in nonpaired, primary tumor specimens by use of affymetrix single-nucleotide-polymorphism genotyping microarrays.
American journal of human genetics 2007;81(1):114-26.
2007: Ikezoe Takayuki; Yang Jing; Nishioka Chie; Tasaka Taizo; Taniguchi Ayuko; Kuwayama Yoshio; Komatsu Naoki; Bandobashi Kentaro; Togitani Kazuto; Koeffler H Phillip; Taguchi Hirokuni
A novel treatment strategy targeting Aurora kinases in acute myelogenous leukemia.
Molecular cancer therapeutics 2007;6(6):1851-7.
2007: Wolf Ido; O'Kelly James; Wakimoto Naoki; Nguyen Anh; Amblard Franck; Karlan Beth Y; Arbiser Jack L; Koeffler H Phillip
Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest.
International journal of oncology 2007;30(6):1529-37.
2007: Nishioka C; Ikezoe T; Takeshita A; Yang J; Tasaka T; Yang Y; Kuwayama Y; Komatsu N; Togitani K; Koeffler H P; Taguchi H
ZD6474 induces growth arrest and apoptosis of human leukemia cells, which is enhanced by concomitant use of a novel MEK inhibitor, AZD6244.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2007;21(6):1308-10.
2007: Gombart Adrian F; Grewal Jeffrey; Koeffler H Phillip
ATF4 differentially regulates transcriptional activation of myeloid-specific genes by C/EBPepsilon and C/EBPalpha.
Journal of leukocyte biology 2007;81(6):1535-47.
2007: Tanaka Miyuki; Gombart Adrian F; Koeffler H Phillip; Shiohara Masaaki
Expression of bactericidal/permeability-increasing protein requires C/EBP epsilon.
International journal of hematology 2007;85(4):304-11.
2007: Nishioka C; Ikezoe T; Yang J; Koeffler H P; Taguchi H
Fludarabine induces apoptosis of human T-cell leukemia virus type 1-infected T cells via inhibition of the nuclear factor-kappaB signal pathway.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2007;21(5):1044-9.
2007: Desmond J C; Raynaud S; Tung E; Hofmann W-K; Haferlach T; Koeffler H P
Discovery of epigenetically silenced genes in acute myeloid leukemias.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2007;21(5):1026-34.
2007: Chumakov Alexey M; Silla Agnes; Williamson Elizabeth A; Koeffler H Phillip
Modulation of DNA binding properties of CCAAT/enhancer binding protein epsilon by heterodimer formation and interactions with NFkappaB pathway.
Blood 2007;109(10):4209-19.
2007: Garon Edward B; Marcu Laura; Luong Quang; Tcherniantchouk Oxana; Crooks Gay M; Koeffler H Phillip
Quantum dot labeling and tracking of human leukemic, bone marrow and cord blood cells.
Leukemia research 2007;31(5):643-51.
2007: Ikezoe Takayuki; Nishioka Chie; Bandobashi Kentaro; Yang Yang; Kuwayama Yoshio; Adachi Yoshihiro; Takeuchi Tamotsu; Koeffler H Phillip; Taguchi Hirokuni
Longitudinal inhibition of PI3K/Akt/mTOR signaling by LY294002 and rapamycin induces growth arrest of adult T-cell leukemia cells.
Leukemia research 2007;31(5):673-82.
2007: Gery Sigal; Park Dorothy J; Vuong Peter T; Virk Renu K; Muller Claudia I; Hofmann Wolf-K; Koeffler H Phillip
RTP801 is a novel retinoic acid-responsive gene associated with myeloid differentiation.
Experimental hematology 2007;35(4):572-8.
2007: Liu Dong-Ping; Wang Yan; Koeffler H Phillip; Xie Dong
Ephrin-A1 is a negative regulator in glioma through down-regulation of EphA2 and FAK.
International journal of oncology 2007;30(4):865-71.
2007: Kumagai Takashi; Müller Claudia I; Desmond Julian C; Imai Yasufumi; Heber David; Koeffler H Phillip
Scutellaria baicalensis, a herbal medicine: anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines.
Leukemia research 2007;31(4):523-30.
2007: Gombart Adrian F; O'Kelly James; Saito Tsuyako; Koeffler H Phillip
Regulation of the CAMP gene by 1,25(OH)2D3 in various tissues.
The Journal of steroid biochemistry and molecular biology 2007;103(3-5):552-7.
2007: Wang Yan; Liu Dong-Ping; Chen Ping-Ping; Koeffler H Phillip; Tong Xiang-Jun; Xie Dong
Involvement of IFN regulatory factor (IRF)-1 and IRF-2 in the formation and progression of human esophageal cancers.
Cancer research 2007;67(6):2535-43.
2007: Gery Sigal; Komatsu Naoki; Kawamata Norihiko; Miller Carl W; Desmond Julian; Virk Renu K; Marchevsky Alberto; Mckenna Robert; Taguchi Hirokuni; Koeffler H Phillip
Epigenetic silencing of the candidate tumor suppressor gene Per1 in non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(5):1399-404.
2007: Wolf Ido; Bose Shikha; Williamson Elizabeth A; Miller Carl W; Karlan Beth Y; Koeffler H Phillip
FOXA1: Growth inhibitor and a favorable prognostic factor in human breast cancer.
International journal of cancer. Journal international du cancer 2007;120(5):1013-22.
2007: Walsh Christine S; Miller Carl W; Karlan Beth Y; Koeffler H Phillip
Association between a functional single nucleotide polymorphism in the MDM2 gene and sporadic endometrial cancer risk.
Gynecologic oncology 2007;104(3):660-4.
2007: Yin Dong; Ong John M; Hu Jinwei; Desmond Julian C; Kawamata Norihiko; Konda Bindu M; Black Keith L; Koeffler H Phillip
Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor: effects on gene expression and growth of glioma cells in vitro and in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(3):1045-52.
2007: Gery Sigal; Koeffler H Phillip
Transcription factors in hematopoietic malignancies.
Current opinion in genetics & development 2007;17(1):78-83.
2007: Haritunians T; Mori A; O'Kelly J; Luong Q T; Giles F J; Koeffler H P
Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphoma.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2007;21(2):333-9.
2007: Yin Dong; Komatsu Naoki; Miller Carl W; Chumakov Alexey M; Marschesky Alberto; McKenna Robert; Black Keith L; Koeffler H Phillip
KLF6: mutational analysis and effect on cancer cell proliferation.
International journal of oncology 2007;30(1):65-72.
2007: Müller Claudia I; Miller Carl W; Hofmann Wolf-K; Gross Mitchell E; Walsh Christine S; Kawamata Norihiko; Luong Quang T; Koeffler H Phillip
Rare mutations of the PIK3CA gene in malignancies of the hematopoietic system as well as endometrium, ovary, prostate and osteosarcomas, and discovery of a PIK3CA pseudogene.
Leukemia research 2007;31(1):27-32.
2007: Chen Ping-Ping; Li Wen-Jie; Wang Yan; Zhao Song; Li De-Yun; Feng Li-Yun; Shi Xiang-Lin; Koeffler H Phillip; Tong Xiang-Jun; Xie Dong
Expression of Cyr61, CTGF, and WISP-1 correlates with clinical features of lung cancer.
PloS one 2007;2(6):e534.
2006: Yang Y; Ikezoe T; Nishioka C; Bandobashi K; Takeuchi T; Adachi Y; Kobayashi M; Takeuchi S; Koeffler H P; Taguchi H
NFV, an HIV-1 protease inhibitor, induces growth arrest, reduced Akt signalling, apoptosis and docetaxel sensitisation in NSCLC cell lines.
British journal of cancer 2006;95(12):1653-62.
2006: Yang Yang; Ikezoe Takayuki; Nishioka Chie; Taguchi Takahiro; Zhu Wei-Guo; Koeffler H Phillip; Taguchi Hirokuni
ZD6474 induces growth arrest and apoptosis of GIST-T1 cells, which is enhanced by concomitant use of sunitinib.
Cancer science 2006;97(12):1404-9.
2006: Hofmann W-K; Takeuchi S; Takeuchi N; Thiel E; Hoelzer D; Koeffler H P
Comparative analysis of hypermethylation of cell cycle control and DNA-mismatch repair genes in low-density and CD34+ bone marrow cells from patients with myelodysplastic syndrome.
Leukemia research 2006;30(11):1347-53.
2006: Zang Chuanbing; Liu Hongyu; Waechter Marlies; Eucker Jan; Bertz Janina; Possinger Kurt; Koeffler H Phillip; Elstner Elena
Dual PPARalpha/gamma ligand TZD18 either alone or in combination with imatinib inhibits proliferation and induces apoptosis of human CML cell lines.
Cell cycle (Georgetown, Tex.) 2006;5(19):2237-43.
2006: Müller Claudia I; Rüter Björn; Koeffler H Phillip; Lübbert Michael
DNA hypermethylation of myeloid cells, a novel therapeutic target in MDS and AML.
Current pharmaceutical biotechnology 2006;7(5):315-21.
2006: Ikezoe Takayuki; Nishioka Chie; Tasaka Taizo; Yang Yang; Komatsu Naoki; Togitani Kazuto; Koeffler H Phillip; Taguchi Hirokuni
The antitumor effects of sunitinib (formerly SU11248) against a variety of human hematologic malignancies: enhancement of growth inhibition via inhibition of mammalian target of rapamycin signaling.
Molecular cancer therapeutics 2006;5(10):2522-30.
2006: Luong Quang T; O'Kelly James; Braunstein Glenn D; Hershman Jerome M; Koeffler H Phillip
Antitumor activity of suberoylanilide hydroxamic acid against thyroid cancer cell lines in vitro and in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(18):5570-7.
2006: Ikezoe Takayuki; Yang Yang; Nishioka Chie; Bandobashi Kentaro; Nakatani Hajime; Taguchi Takahiro; Koeffler H Phillip; Taguchi Hirokuni
Effect of SU11248 on gastrointestinal stromal tumor-T1 cells: enhancement of growth inhibition via inhibition of 3-kinase/Akt/mammalian target of rapamycin signaling.
Cancer science 2006;97(9):945-51.
2006: Wolf Ido; O'Kelly James; Rubinek Tamar; Tong Min; Nguyen Anh; Lin Bryan T; Tai Hsin-Hsiung; Karlan Beth Y; Koeffler H Phillip
15-hydroxyprostaglandin dehydrogenase is a tumor suppressor of human breast cancer.
Cancer research 2006;66(15):7818-23.
2006: Chien Wenwen; Yin Dong; Gui Dorina; Mori Akio; Frank Jonathan Mordechai; Said Jonathan; Kusuanco Donato; Marchevsky Alberto; McKenna Robert; Koeffler H Phillip
Suppression of cell proliferation and signaling transduction by connective tissue growth factor in non-small cell lung cancer cells.
Molecular cancer research : MCR 2006;4(8):591-8.
2006: Ikezoe Takayuki; Yang Yang; Saitoh Takayuki; Heber David; McKenna Robert; Taguchi Hirokuni; Koeffler H Phillip
PC-SPES down-regulates COX-2 via inhibition of NF-kappaB and C/EBPbeta in non-small cell lung cancer cells.
International journal of oncology 2006;29(2):453-61.
2006: O'Kelly James; Uskokovic Milan; Lemp Nathan; Vadgama Jay; Koeffler H Phillip
Novel Gemini-vitamin D3 analog inhibits tumor cell growth and modulates the Akt/mTOR signaling pathway.
The Journal of steroid biochemistry and molecular biology 2006;100(4-5):107-16.
2006: Ikezoe Takayuki; Bandobashi Kentaro; Yang Yang; Takeuchi Seisho; Sekiguchi Nobuo; Sakai Shuichi; Koeffler H Phillip; Taguchi Hirokuni
HIV-1 protease inhibitor ritonavir potentiates the effect of 1,25-dihydroxyvitamin D3 to induce growth arrest and differentiation of human myeloid leukemia cells via down-regulation of CYP24.
Leukemia research 2006;30(8):1005-11.
2006: Gombart Adrian F; Luong Quang T; Koeffler H Phillip
Vitamin D compounds: activity against microbes and cancer.
Anticancer research 2006;26(4A):2531-42.
2006: Müller Claudia I; Kumagai Takashi; O'Kelly James; Seeram Navindra P; Heber David; Koeffler H Phillip
Ganoderma lucidum causes apoptosis in leukemia, lymphoma and multiple myeloma cells.
Leukemia research 2006;30(7):841-8.
2006: Yang Yang; Ikezoe Takayuki; Takeuchi Tamotsu; Adachi Yoshihiro; Ohtsuki Yuji; Koeffler H Phillip; Taguchi Hirokuni
Zanthoxyli Fructus induces growth arrest and apoptosis of LNCaP human prostate cancer cells in vitro and in vivo in association with blockade of the AKT and AR signal pathways.
Oncology reports 2006;15(6):1581-90.
2006: Gery Sigal; Komatsu Naoki; Baldjyan Lilit; Yu Andrew; Koo Danielle; Koeffler H Phillip
The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells.
Molecular cell 2006;22(3):375-82.
2006: Liu Hongyu; Zang Chuanbing; Fenner Martin H; Liu Dachuan; Possinger Kurt; Koeffler H Phillip; Elstner Elena
Growth inhibition and apoptosis in human Philadelphia chromosome-positive lymphoblastic leukemia cell lines by treatment with the dual PPARalpha/gamma ligand TZD18.
Blood 2006;107(9):3683-92.
2006: Mori Akio; Lehmann Sören; O'Kelly James; Kumagai Takashi; Desmond Julian C; Pervan Milena; McBride William H; Kizaki Masahiro; Koeffler H Phillip
Capsaicin, a component of red peppers, inhibits the growth of androgen-independent, p53 mutant prostate cancer cells.
Cancer research 2006;66(6):3222-9.
2006: Williamson E A; Wolf I; O'Kelly J; Bose S; Tanosaki S; Koeffler H P
BRCA1 and FOXA1 proteins coregulate the expression of the cell cycle-dependent kinase inhibitor p27(Kip1).
Oncogene 2006;25(9):1391-9.
2006: Yin D; Xie D; Sakajiri S; Miller C W; Zhu H; Popoviciu M L; Said J W; Black K L; Koeffler H P
DLK1: increased expression in gliomas and associated with oncogenic activities.
Oncogene 2006;25(13):1852-61.
2006: Komatsu Naoki; Kawamata Norihiko; Takeuchi Seisho; Yin Dong; Chien Wenwen; Miller Carl W; Koeffler H Phillip
SAHA, a HDAC inhibitor, has profound anti-growth activity against non-small cell lung cancer cells.
Oncology reports 2006;15(1):187-91.
2006: Yang Yang; Takeuchi Seisho; Hofmann Wolf K; Ikezoe Takayuki; van Dongen Jacques J M; Szczepanski Tomasz; Bartram Claus R; Yoshino Norihide; Taguchi Hirokuni; Koeffler H Phillip
Aberrant methylation in promoter-associated CpG islands of multiple genes in acute lymphoblastic leukemia.
Leukemia research 2006;30(1):98-102.
2005: Takai Noriyuki; Jain Anjali; Kawamata Norihiko; Popoviciu Laura M; Said Jonathan W; Whittaker Sadie; Miyakawa Isao; Agus David B; Koeffler H Phillip
2C4, a monoclonal antibody against HER2, disrupts the HER kinase signaling pathway and inhibits ovarian carcinoma cell growth.
Cancer 2005;104(12):2701-8.
2005: Desmond Julian C; Kawabata Hiroshi; Mueller-Tidow Carsten; Simamura Eriko; Heber David; Hirai Kei-Ichi; Koeffler H Phillip
The synthetic furanonaphthoquinone induces growth arrest, apoptosis and differentiation in a variety of leukaemias and multiple myeloma cells.
British journal of haematology 2005;131(4):520-9.
2005: Gombart Adrian F; Krug Utz; O'Kelly James; An Eun; Vegesna Vijaya; Koeffler H Phillip
Aberrant expression of neutrophil and macrophage-related genes in a murine model for human neutrophil-specific granule deficiency.
Journal of leukocyte biology 2005;78(5):1153-65.
2005: Koeffler H Phillip; Aslanian Noune; O'Kelly James
Vitamin D(2) analog (Paricalcitol; Zemplar) for treatment of myelodysplastic syndrome.
Leukemia research 2005;29(11):1259-62.
2005: Paz-Priel Ido; Cai Dong Hong; Wang Dehua; Kowalski Jeanne; Blackford Amanda; Liu Huaitian; Heckman Caroline A; Gombart Adrian F; Koeffler H Phillip; Boxer Linda M; Friedman Alan D
CCAAT/enhancer binding protein alpha (C/EBPalpha) and C/EBPalpha myeloid oncoproteins induce bcl-2 via interaction of their basic regions with nuclear factor-kappaB p50.
Molecular cancer research : MCR 2005;3(10):585-96.
2005: Gery Sigal; Xie Dong; Yin Dong; Gabra Hani; Miller Carl; Wang Heming; Scott Diane; Yi William S; Popoviciu Miriam L; Said Johathan W; Koeffler H Phillip
Ovarian carcinomas: CCN genes are aberrantly expressed and CCN1 promotes proliferation of these cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(20):7243-54.
2005: Luong Quang T; Koeffler H Phillip
Vitamin D compounds in leukemia.
The Journal of steroid biochemistry and molecular biology 2005;97(1-2):195-202.
2005: Gery Sigal; Gombart Adrian F; Yi William S; Koeffler Chloe; Hofmann Wolf-K; Koeffler H Phillip
Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia.
Blood 2005;106(8):2827-36.
2005: Müller Claudia I; Miller Carl W; Kawabata Hiroshi; McKenna Robert J; Marchevsky Alberto M; Koeffler H Phillip
Do cancer cells selectively mutate HFE to increase their intracellular iron?
Oncology reports 2005;14(2):299-303.
2005: Sakajiri S; O'kelly J; Yin D; Miller C W; Hofmann W K; Oshimi K; Shih L-Y; Kim K-H; Sul H S; Jensen C H; Teisner B; Kawamata N; Koeffler H P
Dlk1 in normal and abnormal hematopoiesis.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2005;19(8):1404-10.
2005: Yang Yang; Ikezoe Takayuki; Takeuchi Tamotsu; Adachi Yoshihiro; Ohtsuki Yuji; Takeuchi Seisho; Koeffler H Phillip; Taguchi Hirokuni
HIV-1 protease inhibitor induces growth arrest and apoptosis of human prostate cancer LNCaP cells in vitro and in vivo in conjunction with blockade of androgen receptor STAT3 and AKT signaling.
Cancer science 2005;96(7):425-33.
2005: Gombart Adrian F; Borregaard Niels; Koeffler H Phillip
Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(9):1067-77.
2005: Matsushita Masahide; Takeuchi Seisho; Yang Yang; Yoshino Norihide; Tsukasaki Kunihiro; Taguchi Hirokuni; Koeffler H Phillip; Seo Hiromi
Methylation of the MLH1 gene in hematological malignancies.
Oncology reports 2005;14(1):191-4.
2005: Ikezoe Takayuki; Gery Sigal; Yin Dong; O'Kelly James; Binderup Lise; Lemp Nathan; Taguchi Hirokuni; Koeffler H Phillip
CCAAT/enhancer-binding protein delta: a molecular target of 1,25-dihydroxyvitamin D3 in androgen-responsive prostate cancer LNCaP cells.
Cancer research 2005;65(11):4762-8.
2005: Takai Noriyuki; Kawamata Norihiko; Walsh Christine S; Gery Sigal; Desmond Julian C; Whittaker Sadie; Said Jonathan W; Popoviciu Laura M; Jones Peter A; Miyakawa Isao; Koeffler H Phillip
Discovery of epigenetically masked tumor suppressor genes in endometrial cancer.
Molecular cancer research : MCR 2005;3(5):261-9.
2005: Gery Sigal; Tanosaki Sakae; Bose Shikha; Bose Namrata; Vadgama Jay; Koeffler H Phillip
Down-regulation and growth inhibitory role of C/EBPalpha in breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(9):3184-90.
2005: Jones Letetia C; Tefferi Ayalew; Vuong Peter T; Desmond Julian C; Hofmann Wolf-K; Koeffler H Phillip
Detection of aberrant gene expression in CD34+ hematopoietic stem cells from patients with agnogenic myeloid metaplasia using oligonucleotide microarrays.
Stem cells (Dayton, Ohio) 2005;23(5):631-7.
2005: Kawamata Norihiko; Sugimoto Kei-Ji; Sakajiri Sakura; Oshimi Kazuo; Koeffler H Phillip
Mxi1 isoforms are expressed in hematological cell lines and normal bone marrow.
International journal of oncology 2005;26(5):1369-75.
2005: Kumagai Takashi; Tefferi Ayalew; Jones Letetia; Koeffler H Phillip
Methylation analysis of the cell cycle control genes in myelofibrosis with myeloid metaplasia.
Leukemia research 2005;29(5):511-5.
2005: Williamson Elizabeth A; Williamson Ian K; Chumakov Alexey M; Friedman Alan D; Koeffler H Phillip
CCAAT/enhancer binding protein epsilon: changes in function upon phosphorylation by p38 MAP kinase.
Blood 2005;105(10):3841-7.
2005: Ikezoe Takayuki; Yang Yang; Bandobashi Kentaro; Saito Tsuyako; Takemoto Shigeki; Machida Hisanori; Togitani Kazuto; Koeffler H Phillip; Taguchi Hirokuni
Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-kappa B signal pathways.
Molecular cancer therapeutics 2005;4(4):578-86.
2005: Kumagai Takashi; Shih Lee-Yung; Hughes Susan V; Desmond Julian C; O'Kelly James; Hewison Martin; Koeffler H Phillip
19-Nor-1,25(OH)2D2 (a novel, noncalcemic vitamin D analogue), combined with arsenic trioxide, has potent antitumor activity against myeloid leukemia.
Cancer research 2005;65(6):2488-97.
2005: Mhawech Paulette; Benz Ana; Cerato Christelle; Greloz Vincent; Assaly Mounia; Desmond Julian C; Koeffler H Phillip; Lodygin Dimitri; Hermeking Heiko; Herrmann François; Schwaller Juerg
Downregulation of 14-3-3sigma in ovary, prostate and endometrial carcinomas is associated with CpG island methylation.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2005;18(3):340-8.
2005: Gery Sigal; Tanosaki Sakae; Hofmann Wolf-K; Koppel Ahrin; Koeffler H Phillip
C/EBPdelta expression in a BCR-ABL-positive cell line induces growth arrest and myeloid differentiation.
Oncogene 2005;24(9):1589-97.
2005: Sakajiri Sakura; Kumagai Takashi; Kawamata Norihiko; Saitoh Takayuki; Said Jonathan W; Koeffler H Phillip
Histone deacetylase inhibitors profoundly decrease proliferation of human lymphoid cancer cell lines.
Experimental hematology 2005;33(1):53-61.
2005: Yang Yang; Takeuchi Seisho; Tsukasaki Kunihiro; Yamada Yasuaki; Hata Tomoko; Mori Naoki; Fukushima Atsuki; Seo Hiromi; Koeffler H Phillip; Taguchi Hirokuni
Methylation analysis of the adenomatous polyposis coli (APC) gene in adult T-cell leukemia/lymphoma.
Leukemia research 2005;29(1):47-51.
2005: Yin Dong; Zhou Hong; Kumagai Takashi; Liu Gentao; Ong John M; Black Keith L; Koeffler H Phillip
Proteasome inhibitor PS-341 causes cell growth arrest and apoptosis in human glioblastoma multiforme (GBM).
Oncogene 2005;24(3):344-54.
2005: Kawabata Hiroshi; Fleming Robert E; Gui Dorina; Moon Seo Y; Saitoh Takayuki; O'Kelly James; Umehara Yutaka; Wano Yuji; Said Jonathan W; Koeffler H Phillip
Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis.
Blood 2005;105(1):376-81.
2005: Hofmann Wolf-K; Koeffler H Phillip
Myelodysplastic syndrome.
Annual review of medicine 2005;56():1-16.
2004: Chih Doris Y; Park Dorothy J; Gross Mitchell; Idos Gregory; Vuong Peter T; Hirama Toshiyasu; Chumakov Alexey M; Said Jonathan; Koeffler H Phillip
Protein partners of C/EBPepsilon.
Experimental hematology 2004;32(12):1173-81.
2004: Takai Noriyuki; Kawamata Norihiko; Gui Dorina; Said Jonathan W; Miyakawa Isao; Koeffler H Phillip
Human ovarian carcinoma cells: histone deacetylase inhibitors exhibit antiproliferative activity and potently induce apoptosis.
Cancer 2004;101(12):2760-70.
2004: Worch Jennifer; Tickenbrock Lara; Schwäble Joachim; Steffen Björn; Cauvet Thomas; Mlody Barbara; Buerger Horst; Koeffler H Phillip; Berdel Wolfgang E; Serve Hubert; Müller-Tidow Carsten
The serine-threonine kinase MNK1 is post-translationally stabilized by PML-RARalpha and regulates differentiation of hematopoietic cells.
Oncogene 2004;23(57):9162-72.
2004: Chien Wenwen; Kumagai Takashi; Miller Carl W; Desmond Julian C; Frank Jonathan M; Said Jonathan W; Koeffler H Phillip
Cyr61 suppresses growth of human endometrial cancer cells.
The Journal of biological chemistry 2004;279(51):53087-96.
2004: Gery Sigal; Park Dorothy J; Vuong Peter T; Chih Doris Y; Lemp Nathan; Koeffler H Phillip
Retinoic acid regulates C/EBP homologous protein expression (CHOP), which negatively regulates myeloid target genes.
Blood 2004;104(13):3911-7.
2004: Kawabata Hiroshi; Tong Xiangjun; Kawanami Takafumi; Wano Yuji; Hirose Yuko; Sugai Susumu; Koeffler H Phillip
Analyses for binding of the transferrin family of proteins to the transferrin receptor 2.
British journal of haematology 2004;127(4):464-73.
2004: Ikezoe Takayuki; Hisatake Yasuko; Takeuchi Tamotsu; Ohtsuki Yuji; Yang Yang; Said Jonathan W; Taguchi Hirokuni; Koeffler H Phillip
HIV-1 protease inhibitor, ritonavir: a potent inhibitor of CYP3A4, enhanced the anticancer effects of docetaxel in androgen-independent prostate cancer cells in vitro and in vivo.
Cancer research 2004;64(20):7426-31.
2004: Konopleva Marina; Elstner Elena; McQueen Teresa J; Tsao Twee; Sudarikov Andrey; Hu Wei; Schober Wendy D; Wang Rui-Yu; Chism David; Kornblau Steven M; Younes Anas; Collins Steven J; Koeffler H Phillip; Andreeff Michael
Peroxisome proliferator-activated receptor gamma and retinoid X receptor ligands are potent inducers of differentiation and apoptosis in leukemias.
Molecular cancer therapeutics 2004;3(10):1249-62.
2004: Müller-Tidow Carsten; Ji Ping; Diederichs Sven; Potratz Jenny; Bäumer Nicole; Köhler Gabriele; Cauvet Thomas; Choudary Chunaram; van der Meer Tiffany; Chan Wan-Yu Iris; Nieduszynski Conrad; Colledge William H; Carrington Mark; Koeffler H Phillip; Restle Anja; Wiesmüller Lisa; Sobczak-Thépot Joëlle; Berdel Wolfgang E; Serve Hubert
The cyclin A1-CDK2 complex regulates DNA double-strand break repair.
Molecular and cellular biology 2004;24(20):8917-28.
2004: Jones Letetia C; Tefferi Ayalew; Idos Gregory E; Kumagai Takashi; Hofmann Wolf-K; Koeffler H Phillip
RARbeta2 is a candidate tumor suppressor gene in myelofibrosis with myeloid metaplasia.
Oncogene 2004;23(47):7846-53.
2004: Takeuchi Seisho; Takeuchi Naoko; Tsukasaki Kunihiro; Yang Yang; Fermin Anthony C; Tomonaga Masao; Miller Carl W; Seo Hiromi; Koeffler H Phillip
Methylenetetrahydrofolate reductase genotype does not play a role in adult T-cell leukemia/lymphoma pathogenesis among human T-lymphotrophic virus type 1 carriers.
Leukemia research 2004;28(10):1039-41.
2004: Morosetti Roberta; Servidei Tiziana; Mirabella Massimiliano; Rutella Sergio; Mangiola Annunziato; Maira Giulio; Mastrangelo Renato; Koeffler H Phillip
The PPARgamma ligands PGJ2 and rosiglitazone show a differential ability to inhibit proliferation and to induce apoptosis and differentiation of human glioblastoma cell lines.
International journal of oncology 2004;25(2):493-502.
2004: Diederichs Sven; Bäumer Nicole; Ji Ping; Metzelder Stephan K; Idos Gregory E; Cauvet Thomas; Wang Wenbing; Möller Maria; Pierschalski Sarah; Gromoll Jörg; Schrader Mark G; Koeffler H Phillip; Berdel Wolfgang E; Serve Hubert; Müller-Tidow Carsten
Identification of interaction partners and substrates of the cyclin A1-CDK2 complex.
The Journal of biological chemistry 2004;279(32):33727-41.
2004: Matsushita Chise; Yang Yang; Takeuchi Seisho; Matsushita Masahide; Van Dongen Jacques J M; Szczepanski Tomasz; Bartram Claus R; Seo Hiromi; Koeffler H Phillip; Taguchi Hirokuni
Aberrant methylation in promoter-associated CpG islands of multiple genes in relapsed childhood acute lymphoblastic leukemia.
Oncology reports 2004;12(1):97-9.
2004: Ikezoe Takayuki; Tanosaki Sakae; Krug Utz; Liu Bingrong; Cohen Pinchas; Taguchi Hirokuni; Koeffler H Phillip
Insulin-like growth factor binding protein-3 antagonizes the effects of retinoids in myeloid leukemia cells.
Blood 2004;104(1):237-42.
2004: Takeuchi Seisho; de Vos Sven; Takeuchi Naoko; Fermin Anthony C; Grogan Thomas M; Seo Hiromi; Said Jonathan W; Koeffler H Phillip
Allelic loss during progression of follicular lymphoma.
Leukemia research 2004;28(6):567-9.
2004: Tong Xiangjun; O'Kelly James; Xie Dong; Mori Akio; Lemp Nathan; McKenna Robert; Miller Carl W; Koeffler H Phillip
Cyr61 suppresses the growth of non-small-cell lung cancer cells via the beta-catenin-c-myc-p53 pathway.
Oncogene 2004;23(28):4847-55.
2004: Ikezoe T; Yang Y; Taguchi H; Koeffler H P
JNK interacting protein 1 (JIP-1) protects LNCaP prostate cancer cells from growth arrest and apoptosis mediated by 12-0-tetradecanoylphorbol-13-acetate (TPA).
British journal of cancer 2004;90(10):2017-24.
2004: Tsukasaki Kunihiro; Tanosaki Sakae; DeVos Sven; Hofmann Wolf K; Wachsman William; Gombart Adrian F; Krebs Johannes; Jauch Anna; Bartram Claus R; Nagai Kazuhiro; Tomonaga Masao; Said Jonathan W; Koeffler H Phillip
Identifying progression-associated genes in adult T-cell leukemia/lymphoma by using oligonucleotide microarrays.
International journal of cancer. Journal international du cancer 2004;109(6):875-81.
2004: Ikezoe Takayuki; Saito Tsuyako; Bandobashi Kentaro; Yang Yang; Koeffler H Phillip; Taguchi Hirokuni
HIV-1 protease inhibitor induces growth arrest and apoptosis of human multiple myeloma cells via inactivation of signal transducer and activator of transcription 3 and extracellular signal-regulated kinase 1/2.
Molecular cancer therapeutics 2004;3(4):473-9.
2004: Chumakov Alexey M; Kubota Tetsuya; Walter Steffen; Koeffler H Phillip
Identification of murine and human XCP1 genes as C/EBP-epsilon-dependent members of FIZZ/Resistin gene family.
Oncogene 2004;23(19):3414-25.
2004: Müller-Tidow Carsten; Steffen Björn; Cauvet Thomas; Tickenbrock Lara; Ji Ping; Diederichs Sven; Sargin Bülent; Köhler Gabriele; Stelljes Matthias; Puccetti Elena; Ruthardt Martin; deVos Sven; Hiebert Scott W; Koeffler H Phillip; Berdel Wolfgang E; Serve Hubert
Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.
Molecular and cellular biology 2004;24(7):2890-904.
2004: Yin Dong; Xie Dong; De Vos Sven; Liu Gentao; Miller Carl W; Black Keith L; Koeffler H Phillip
Imprinting status of DLK1 gene in brain tumors and lymphomas.
International journal of oncology 2004;24(4):1011-5.
2004: Xie Dong; Yin Dong; Wang He-Jing; Liu Gen-Tao; Elashoff Robert; Black Keith; Koeffler H Phillip
Levels of expression of CYR61 and CTGF are prognostic for tumor progression and survival of individuals with gliomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(6):2072-81.
2004: Xie Dong; Yin Dong; Tong Xiangjun; O'Kelly James; Mori Akio; Miller Carl; Black Keith; Gui Dorina; Said Johathan W; Koeffler H Phillip
Cyr61 is overexpressed in gliomas and involved in integrin-linked kinase-mediated Akt and beta-catenin-TCF/Lef signaling pathways.
Cancer research 2004;64(6):1987-96.
2004: Ikezoe Takayuki; Yang Yang; Saito Tsuyako; Koeffler H Phillip; Taguchi Hirokuni
Proteasome inhibitor PS-341 down-regulates prostate-specific antigen (PSA) and induces growth arrest and apoptosis of androgen-dependent human prostate cancer LNCaP cells.
Cancer science 2004;95(3):271-5.
2004: Kumagai Takashi; Ikezoe Takayuki; Gui Dorina; O'Kelly James; Tong Xiang-Jun; Cohen Fredric J; Said Jonathan W; Koeffler H Phillip
RWJ-241947 (MCC-555), a unique peroxisome proliferator-activated receptor-gamma ligand with antitumor activity against human prostate cancer in vitro and in beige/nude/ X-linked immunodeficient mice and enhancement of apoptosis in myeloma cells induced by arsenic trioxide.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(4):1508-20.
2004: Yang Yang; Ikezoe Takeyuki; Saito Tsuyako; Kobayashi Makoto; Koeffler H Phillip; Taguchi Hirokuni
Proteasome inhibitor PS-341 induces growth arrest and apoptosis of non-small cell lung cancer cells via the JNK/c-Jun/AP-1 signaling.
Cancer science 2004;95(2):176-80.
2004: Takai Noriyuki; Desmond Julian C; Kumagai Takashi; Gui Dorina; Said Jonathan W; Whittaker Sadie; Miyakawa Isao; Koeffler H Phillip
Histone deacetylase inhibitors have a profound antigrowth activity in endometrial cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(3):1141-9.
2004: Shiohara Masaaki; Gombart Adrian F; Sekiguchi Yukio; Hidaka Eiko; Ito Susumu; Yamazaki Takashi; Koeffler H Phillip; Komiyama Atsushi
Phenotypic and functional alterations of peripheral blood monocytes in neutrophil-specific granule deficiency.
Journal of leukocyte biology 2004;75(2):190-7.
2004: Gery Sigal; Gombart Adrian F; Fung Yuen K; Koeffler H Phillip
C/EBPepsilon interacts with retinoblastoma and E2F1 during granulopoiesis.
Blood 2004;103(3):828-35.
2004: Rummel Mathias J; de Vos Sven; Hoelzer Dieter; Koeffler H Phillip; Hofmann Wolf-K
Altered apoptosis pathways in mantle cell lymphoma.
Leukemia & lymphoma 2004;45(1):49-54.
2004: Lee Kuk-Wha; Liu Bingrong; Ma Liqun; Li Heju; Bang Peter; Koeffler H Phillip; Cohen Pinchas
Cellular internalization of insulin-like growth factor binding protein-3: distinct endocytic pathways facilitate re-uptake and nuclear localization.
The Journal of biological chemistry 2004;279(1):469-76.
2004: Servidei Tiziana; Morosetti Roberta; Ferlini Cristiano; Cusano Gabriella; Scambia Giovanni; Mastrangelo Renato; Koeffler H Phillip
The cellular response to PPARgamma ligands is related to the phenotype of neuroblastoma cell lines.
Oncology research 2004;14(7-8):345-54.
2003: Ikezoe Takayuki; Yang Yang; Heber David; Taguchi Hirokuni; Koeffler H Phillip
PC-SPES: a potent inhibitor of nuclear factor-kappa B rescues mice from lipopolysaccharide-induced septic shock.
Molecular pharmacology 2003;64(6):1521-9.
2003: Tavor Sigal; Park Dorothy J; Gery Sigal; Vuong Peter T; Gombart Adrian F; Koeffler H Phillip
Restoration of C/EBPalpha expression in a BCR-ABL+ cell line induces terminal granulocytic differentiation.
The Journal of biological chemistry 2003;278(52):52651-9.
2003: Zang Chuanbing; Wächter Marlies; Liu Hongyu; Posch Maximilian G; Fenner Martin H; Stadelmann Christine; von Deimling Andreas; Possinger Kurt; Black Keith L; Koeffler H Phillip; Elstner Elena
Ligands for PPARgamma and RAR cause induction of growth inhibition and apoptosis in human glioblastomas.
Journal of neuro-oncology 2003;65(2):107-18.
2003: Ikezoe Takayuki; Chen Sophie S; Yang Yang; Heber David; Taguchi Hirokuni; Koeffler H Phillip
PC-SPES: Molecular mechanism to induce apoptosis and down-regulate expression of PSA in LNCaP human prostate cancer cells.
International journal of oncology 2003;23(5):1461-70.
2003: Park Dorothy J; Vuong Peter T; de Vos Sven; Douer Dan; Koeffler H Phillip
Comparative analysis of genes regulated by PML/RAR alpha and PLZF/RAR alpha in response to retinoic acid using oligonucleotide arrays.
Blood 2003;102(10):3727-36.
2003: Takeuchi Seisho; Seriu Taku; van Dongen Jacques J M; Szczepanski Tomasz; Tsukasaki Kunihiro; Takeuchi Naoko; Fermin Anthony C; Seo Hiromi; Bartram Claus R; Koeffler H Phillip
Allelotype analysis in relapsed childhood acute lymphoblastic leukemia.
Oncogene 2003;22(44):6970-6.
2003: Ikezoe Takayuki; Chen Sophie; Saito Tsuyako; Asou Hiroya; Kyo Taiichi; Tanosaki Sakae; Heber David; Taguchi Hirokuni; Koeffler H Phillip
PC-SPES decreases proliferation and induces differentiation and apoptosis of human acute myeloid leukemia cells.
International journal of oncology 2003;23(4):1203-11.
2003: Ikezoe Takayuki; Chen Sophie S; Tong Xian-Jun; Heber David; Taguchi Hirokuni; Koeffler H Phillip
Oridonin induces growth inhibition and apoptosis of a variety of human cancer cells.
International journal of oncology 2003;23(4):1187-93.
2003: Uehara Eisuke; Takeuchi Seisho; Tasaka Taizo; Matsuhashi Yoshiko; Yang Yang; Fujita Mitsuhiro; Tamura Takahiro; Nagai Masami; Koeffler H Phillip
Aberrant methylation in promoter-associated CpG islands of multiple genes in therapy-related leukemia.
International journal of oncology 2003;23(3):693-6.
2003: Ikezoe Takayuki; Takeuchit Seisho; Komatsu Naoki; Okada Miyuki; Fukushima Atsuki; Ueno Hisayuki; Koeffler H Phillip; Taguchi Hirokuni
Identification of a new GLC1A mutation in a sporadic, primary open-angle glaucoma in Japan.
International journal of molecular medicine 2003;12(2):259-61.
2003: Mori Naoki; Morosetti Roberta; Mizoguchi Hideaki; Koeffler H Phillip
Progression of myelodysplastic syndrome: allelic loss on chromosomal arm 1p.
British journal of haematology 2003;122(2):226-30.
2003: Chien Wenwen; Tidow Nicola; Williamson Elizabeth A; Shih Lee-Yung; Krug Utz; Kettenbach Arminja; Fermin Anthony C; Roifman Chaim M; Koeffler H Phillip
Characterization of a myeloid tyrosine phosphatase, Lyp, and its role in the Bcr-Abl signal transduction pathway.
The Journal of biological chemistry 2003;278(30):27413-20.
2003: Hofmann Wolf-Karsten; Komor Martina; Wassmann Barbara; Jones Letetia C; Gschaidmeier Harald; Hoelzer Dieter; Koeffler H Phillip; Ottmann Oliver G
Presence of the BCR-ABL mutation Glu255Lys prior to STI571 (imatinib) treatment in patients with Ph+ acute lymphoblastic leukemia.
Blood 2003;102(2):659-61.
2003: Tanosaki Sakae; Ikezoe Takayuki; Heaney Anthony; Said Jonathan W; Dan Kazuo; Akashi Makoto; Koeffler H Phillip
Effect of ligands of nuclear hormone receptors on sodium/iodide symporter expression and activity in breast cancer cells.
Breast cancer research and treatment 2003;79(3):335-45.
2003: Kumagai Takashi; O'Kelly James; Said Jonathan W; Koeffler H Phillip
Vitamin D2 analog 19-nor-1,25-dihydroxyvitamin D2: antitumor activity against leukemia, myeloma, and colon cancer cells.
Journal of the National Cancer Institute 2003;95(12):896-905.
2003: Weisbart Richard H; Miller Carl W; Chan Grace; Wakelin Rika; Ferreri Kevin; Koeffler H Phillip
Nuclear delivery of p53 C-terminal peptides into cancer cells using scFv fragments of a monoclonal antibody that penetrates living cells.
Cancer letters 2003;195(2):211-9.
2003: Tong Xiangjun; Xie Dong; Roth Wilfried; Reed John; Koeffler H Phillip
NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo.
International journal of oncology 2003;22(6):1357-62.
2003: Gery Sigal; Yin Dong; Xie Dong; Black Keith L; Koeffler H Phillip
TMEFF1 and brain tumors.
Oncogene 2003;22(18):2723-7.
2003: Gery Sigal; Koeffler H Phillip
Repression of the TMEFF2 promoter by c-Myc.
Journal of molecular biology 2003;328(5):977-83.
2003: Takeuchi Seisho; Takeuchi Naoko; Tsukasaki Kunihiro; Fermin Anthony C; De Vas Sven; Seo Hiromi; Koeffler H Phillip
Mutations in the retinoblastoma-related gene RB2/p130 in adult T-cell leukaemia/lymphoma.
Leukemia & lymphoma 2003;44(4):699-701.
2003: Mori Naoki; Yang Rong; Kawamata Norihiko; Miller Carl W; Mizoguchi Hideaki; Koeffler H Phillip
Absence of R24C mutation of the CDK4 gene in leukemias and solid tumors.
International journal of hematology 2003;77(3):259-62.
2003: Takeuchi Seisho; Takeuchi Naoko; Fermin Anthony C; Taguchi Hirokuni; Koeffler H Phillip
Frameshift mutations in caspase-5 and other target genes in leukemia and lymphoma cell lines having microsatellite instability.
Leukemia research 2003;27(4):359-61.
2003: Gombart Adrian F; Kwok Scott H; Anderson Karen L; Yamaguchi Yuji; Torbett Bruce E; Koeffler H Phillip
Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C/EBP epsilon and PU.1.
Blood 2003;101(8):3265-73.
2003: de Vos Sven; Krug Utz; Hofmann Wolf-Karsten; Pinkus Geraldine S; Swerdlow Steven H; Wachsman William; Grogan Thomas M; Said Jonathan W; Koeffler H Phillip
Cell cycle alterations in the blastoid variant of mantle cell lymphoma (MCL-BV) as detected by gene expression profiling of mantle cell lymphoma (MCL) and MCL-BV.
Diagnostic molecular pathology : the American journal of surgical pathology, part B 2003;12(1):35-43.
2003: Müller-Tidow Carsten; Readhead Carol; Cohen Arthur H; Asotra Kamlesh; Idos Gregory; Diederichs Sven; Cauvet Thomas; Yang Rong; Berdel Wolfgang E; Serve Hubert; Koeffler H Phillip
Successive increases in human cyclin A1 promoter activity during spermatogenesis in transgenic mice.
International journal of molecular medicine 2003;11(3):311-5.
2003: de Vos Sven; Hofmann Wolf-Karsten; Grogan Thomas M; Krug Utz; Schrage Mathew; Miller Thomas P; Braun Jonathan G; Wachsman William; Koeffler H Phillip; Said Jonathan W
Gene expression profile of serial samples of transformed B-cell lymphomas.
Laboratory investigation; a journal of technical methods and pathology 2003;83(2):271-85.
2003: Kaeferstein A; Krug U; Tiesmeier J; Aivado M; Faulhaber M; Stadler M; Krauter J; Germing U; Hofmann W K; Koeffler H P; Ganser A; Verbeek W
The emergence of a C/EBPalpha mutation in the clonal evolution of MDS towards secondary AML.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2003;17(2):343-9.
2003: Asou Hiroya; Gombart Adrian F; Takeuchi Seisho; Tanaka Hideo; Tanioka Maki; Matsui Hirotaka; Kimura Akiro; Inaba Toshiya; Koeffler H Phillip
Establishment of the acute myeloid leukemia cell line Kasumi-6 from a patient with a dominant-negative mutation in the DNA-binding region of the C/EBPalpha gene.
Genes, chromosomes & cancer 2003;36(2):167-74.
2003: Truong Bao-Tran H; Lee Young-Jin; Lodie Tracey A; Park Dorothy J; Perrotti Danilo; Watanabe Naohide; Koeffler H Phillip; Nakajima Hideaki; Tenen Daniel G; Kogan Scott C
CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia.
Blood 2003;101(3):1141-8.
2003: Koeffler H Phillip
Peroxisome proliferator-activated receptor gamma and cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(1):1-9.
2003: Takeuchi S; Tsukasaki K; Bartram C R; Seriu T; Zimmermann M; Schrappe M; Takeuchi N; Park S; Taguchi H; Koeffler H P
Long-term study of the clinical significance of loss of heterozygosity in childhood acute lymphoblastic leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2003;17(1):149-54.
2003: Yin Dong; Xie Dong; Hofmann Wolf-Karsten; Zhang Wenxuan; Asotra Kamlesh; Wong Rex; Black Keith L; Koeffler H Phillip
DNA repair gene O6-methylguanine-DNA methyltransferase: promoter hypermethylation associated with decreased expression and G:C to A:T mutations of p53 in brain tumors.
Molecular carcinogenesis 2003;36(1):23-31.
2003: O'Kelly James; Koeffler H Phillip
Vitamin D analogs and breast cancer.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 2003;164():333-48.
2002: Takeuchi Seisho; Takeuchi Naoko; Tsukasaki Kunihiro; Bartram Claus R; Zimmermann Martin; Schrappe Martin; Taguchi Hirokuni; Koeffler H Phillip
Genetic polymorphisms in the tumour necrosis factor locus in childhood acute lymphoblastic leukaemia.
British journal of haematology 2002;119(4):985-7.
2002: Yin Dong; Xie Dong; Hofmann Wolf-Karsten; Miller Carl W; Black Keith L; Koeffler H Phillip
Methylation, expression, and mutation analysis of the cell cycle control genes in human brain tumors.
Oncogene 2002;21(54):8372-8.
2002: Hofmann Wolf-K; de Vos Sven; Komor Martina; Hoelzer Dieter; Wachsman William; Koeffler H Phillip
Characterization of gene expression of CD34+ cells from normal and myelodysplastic bone marrow.
Blood 2002;100(10):3553-60.
2002: Vegesna Vijaya; O'Kelly James; Uskokovic Milan; Said Jonathan; Lemp Nathan; Saitoh Takayuki; Ikezoe Takayuki; Binderup Lise; Koeffler H Phillip
Vitamin D3 analogs stimulate hair growth in nude mice.
Endocrinology 2002;143(11):4389-96.
2002: Huerta Sergio; Arteaga James R; Irwin Ronald W; Ikezoe Takayuki; Heber David; Koeffler H Phillip
PC-SPES inhibits colon cancer growth in vitro and in vivo.
Cancer research 2002;62(18):5204-9.
2002: Xie Dong; Jauch Anna; Miller Carl W; Bartram Claus R; Koeffler H Phillip
Discovery of over-expressed genes and genetic alterations in breast cancer cells using a combination of suppression subtractive hybridization, multiplex FISH and comparative genomic hybridization.
International journal of oncology 2002;21(3):499-507.
2002: Hofmann Wolf K; Koeffler H Phillip
Important features of myelodysplastic syndrome.
International journal of hematology 2002;76 Suppl 2():222-7.
2002: Hofmann Wolf-K; Tong Xiang-Jun; Ajioka Richard S; Kushner James P; Koeffler H Phillip
Mutation analysis of transferrin-receptor 2 in patients with atypical hemochromatosis.
Blood 2002;100(3):1099-100.
2002: Fleming Robert E; Ahmann John R; Migas Mary C; Waheed Abdul; Koeffler H Phillip; Kawabata Hiroshi; Britton Robert S; Bacon Bruce R; Sly William S
Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10653-8.
2002: Elstner E; Williamson E A; Zang C; Fritz J; Heber D; Fenner M; Possinger K; Koeffler H P
Novel therapeutic approach: ligands for PPARgamma and retinoid receptors induce apoptosis in bcl-2-positive human breast cancer cells.
Breast cancer research and treatment 2002;74(2):155-65.
2002: Gery Sigal; Sawyers Charles L; Agus David B; Said Jonathan W; Koeffler H Phillip
TMEFF2 is an androgen-regulated gene exhibiting antiproliferative effects in prostate cancer cells.
Oncogene 2002;21(31):4739-46.
2002: Williamson Elizabeth A; Dadmanesh Farnaz; Koeffler H Phillip
BRCA1 transactivates the cyclin-dependent kinase inhibitor p27(Kip1).
Oncogene 2002;21(20):3199-206.
2002: Krug Utz; Ganser Arnold; Koeffler H Phillip
Tumor suppressor genes in normal and malignant hematopoiesis.
Oncogene 2002;21(21):3475-95.
2002: Vegesna Vijaya; Takeuchi Seisho; Hofmann Wolf-K; Ikezoe Takayuki; Tavor Sigal; Krug Utz; Fermin Anthony C; Heaney Anthony; Miller Carl W; Koeffler H Phillip
C/EBP-beta, C/EBP-delta, PU.1, AML1 genes: mutational analysis in 381 samples of hematopoietic and solid malignancies.
Leukemia research 2002;26(5):451-7.
2002: O'Kelly James; Hisatake Junichi; Hisatake Yasako; Bishop June; Norman Anthony; Koeffler H Phillip
Normal myelopoiesis but abnormal T lymphocyte responses in vitamin D receptor knockout mice.
The Journal of clinical investigation 2002;109(8):1091-9.
2002: Hofmann Wolf-K; Koeffler H Phillip
Differentiation therapy for myelodysplastic syndrome.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(4):939-41.
2002: Hofmann Wolf K; Takeuchi Seisho; Frantzen Malka A; Hoelzer Dieter; Koeffler H Phillip
Loss of genomic imprinting of insulin-like growth factor 2 is strongly associated with cellular proliferation in normal hematopoietic cells.
Experimental hematology 2002;30(4):318-23.
2002: Jones Letetia C; Lin Meng-Liang; Chen Shih-Shun; Krug Utz; Hofmann Wolf-K; Lee Stephen; Lee Ying-Hue; Koeffler H Phillip
Expression of C/EBPbeta from the C/ebpalpha gene locus is sufficient for normal hematopoiesis in vivo.
Blood 2002;99(6):2032-6.
2002: Hofmann Wolf-K; Jones Letetia C; Lemp Nathan A; de Vos Sven; Gschaidmeier Harald; Hoelzer Dieter; Ottmann Oliver G; Koeffler H Phillip
Ph(+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation.
Blood 2002;99(5):1860-2.
2002: Tavor Sigal; Vuong Peter T; Park Dorothy J; Gombart Adrian F; Cohen Arthur H; Koeffler H Phillip
Macrophage functional maturation and cytokine production are impaired in C/EBP epsilon-deficient mice.
Blood 2002;99(5):1794-801.
2002: Park Woo Hyun; Seol Jae Goo; Kim Eun Shil; Binderup Lise; Koeffler H Phillip; Kim Byoung Kook; Lee Young Yiul
The induction of apoptosis by a combined 1,25(OH)2D3 analog, EB1089 and TGF-beta1 in NCI-H929 multiple myeloma cells.
International journal of oncology 2002;20(3):533-42.
2002: Hofmann Wolf K; de Vos Sven; Elashoff David; Gschaidmeier Harald; Hoelzer Dieter; Koeffler H Phillip; Ottmann Oliver G
Relation between resistance of Philadelphia-chromosome-positive acute lymphoblastic leukaemia to the tyrosine kinase inhibitor STI571 and gene-expression profiles: a gene-expression study.
Lancet 2002;359(9305):481-6.
2002: Tong Xiangjun; Kawabata Hiroshi; Koeffler H Phillip
Iron deficiency can upregulate expression of transferrin receptor at both the mRNA and protein level.
British journal of haematology 2002;116(2):458-64.
2002: Huerta Sergio; Irwin Ronald W; Heber David; Go Vay Liang W; Koeffler H Phillip; Uskokovic Milan R; Harris Diane M
1alpha,25-(OH)(2)-D(3) and its synthetic analogue decrease tumor load in the Apc(min) Mouse.
Cancer research 2002;62(3):741-6.
2002: Gombart Adrian F; Hofmann Wolf-K; Kawano Seiji; Takeuchi Seisho; Krug Utz; Kwok Scott H; Larsen Renee J; Asou Hiroya; Miller Carl W; Hoelzer Dieter; Koeffler H Phillip
Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias.
Blood 2002;99(4):1332-40.
2002: Gombart Adrian F; Koeffler H Phillip
Neutrophil specific granule deficiency and mutations in the gene encoding transcription factor C/EBP(epsilon).
Current opinion in hematology 2002;9(1):36-42.
2002: Miller Carl W; Ikezoe Takayuki; Krug Utz; Hofmann Wolf-K; Tavor Sigal; Vegesna Vijaya; Tsukasaki Kunihiro; Takeuchi Seisho; Koeffler H Phillip
Mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors.
Genes, chromosomes & cancer 2002;33(1):17-21.
2001: Xie D; Nakachi K; Wang H; Elashoff R; Koeffler H P
Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features.
Cancer research 2001;61(24):8917-23.
2001: Ikezoe T; Chen S S; Heber D; Taguchi H; Koeffler H P
Baicalin is a major component of PC-SPES which inhibits the proliferation of human cancer cells via apoptosis and cell cycle arrest.
The Prostate 2001;49(4):285-92.
2001: Tong X; Xie D; O'Kelly J; Miller C W; Muller-Tidow C; Koeffler H P
Cyr61, a member of CCN family, is a tumor suppressor in non-small cell lung cancer.
The Journal of biological chemistry 2001;276(50):47709-14.
2001: Kawabata H; Nakamaki T; Ikonomi P; Smith R D; Germain R S; Koeffler H P
Expression of transferrin receptor 2 in normal and neoplastic hematopoietic cells.
Blood 2001;98(9):2714-9.
2001: Kubota T; Hirama T; Verbeek W; Kawano S; Chih D Y; Chumakov A M; Taguchi H; Koeffler H P
DNase I hypersensitivity analysis of the human CCAAT enhancer binding protein epsilon (C/EBPepsilon) gene.
Leukemia research 2001;25(11):981-95.
2001: Hofmann W K; Takeuchi S; Xie D; Miller C W; Hoelzer D; Koeffler H P
Frequent loss of heterozygosity in the region of D1S450 at 1p36.2 in myelodysplastic syndromes.
Leukemia research 2001;25(10):855-8.
2001: Hofmann W K; Tsukasaki K; Takeuchi N; Takeuchi S; Koeffler H P
Methylation analysis of cell cycle control genes in adult T-cell leukemia/lymphoma.
Leukemia & lymphoma 2001;42(5):1107-9.
2001: Kawabata H; Germain R S; Ikezoe T; Tong X; Green E M; Gombart A F; Koeffler H P
Regulation of expression of murine transferrin receptor 2.
Blood 2001;98(6):1949-54.
2001: Hofmann W K; de Vos S; Tsukasaki K; Wachsman W; Pinkus G S; Said J W; Koeffler H P
Altered apoptosis pathways in mantle cell lymphoma detected by oligonucleotide microarray.
Blood 2001;98(3):787-94.
2001: Tavor S; Takeuchi S; Tsukasaki K; Miller C W; Hofmann W K; Ikezoe T; Said J W; Koeffler H P
Analysis of the CHK2 gene in lymphoid malignancies.
Leukemia & lymphoma 2001;42(3):517-20.
2001: Ikezoe T; Miller C W; Kawano S; Heaney A; Williamson E A; Hisatake J; Green E; Hofmann W; Taguchi H; Koeffler H P
Mutational analysis of the peroxisome proliferator-activated receptor gamma gene in human malignancies.
Cancer research 2001;61(13):5307-10.
2001: Tsukasaki K; Krebs J; Nagai K; Tomonaga M; Koeffler H P; Bartram C R; Jauch A
Comparative genomic hybridization analysis in adult T-cell leukemia/lymphoma: correlation with clinical course.
Blood 2001;97(12):3875-81.
2001: Tsukasaki K; Miller C W; Greenspun E; Eshaghian S; Kawabata H; Fujimoto T; Tomonaga M; Sawyers C; Said J W; Koeffler H P
Mutations in the mitotic check point gene, MAD1L1, in human cancers.
Oncogene 2001;20(25):3301-5.
2001: Tsukasaki K; Miller C W; Kubota T; Takeuchi S; Fujimoto T; Ikeda S; Tomonaga M; Koeffler H P
Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers.
Cancer research 2001;61(9):3770-4.
2001: Gombart A F; Shiohara M; Kwok S H; Agematsu K; Komiyama A; Koeffler H P
Neutrophil-specific granule deficiency: homozygous recessive inheritance of a frameshift mutation in the gene encoding transcription factor CCAAT/enhancer binding protein--epsilon.
Blood 2001;97(9):2561-7.
2001: Tang J G; Koeffler H P
Structural and functional studies of CCAAT/enhancer-binding protein epsilon.
The Journal of biological chemistry 2001;276(21):17739-46.
2001: Shiohara M; Uskokovic M; Hisatake J; Hisatake Y; Koike K; Komiyama A; Koeffler H P
24-Oxo metabolites of vitamin D3 analogues: disassociation of their prominent antileukemic effects from their lack of calcium modulation.
Cancer research 2001;61(8):3361-8.
2001: Xie D; Miller C W; O'Kelly J; Nakachi K; Sakashita A; Said J W; Gornbein J; Koeffler H P
Breast cancer. Cyr61 is overexpressed, estrogen-inducible, and associated with more advanced disease.
The Journal of biological chemistry 2001;276(17):14187-94.
2001: Hisatake J; O'Kelly J; Uskokovic M R; Tomoyasu S; Koeffler H P
Novel vitamin D(3) analog, 21-(3-methyl-3-hydroxy-butyl)-19-nor D(3), that modulates cell growth, differentiation, apoptosis, cell cycle, and induction of PTEN in leukemic cells.
Blood 2001;97(8):2427-33.
2001: Linker-Israeli M; Elstner E; Klinenberg J R; Wallace D J; Koeffler H P
Vitamin D(3) and its synthetic analogs inhibit the spontaneous in vitro immunoglobulin production by SLE-derived PBMC.
Clinical immunology (Orlando, Fla.) 2001;99(1):82-93.
2001: Müller-Tidow C; Wang W; Idos G E; Diederichs S; Yang R; Readhead C; Berdel W E; Serve H; Saville M; Watson R; Koeffler H P
Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function.
Blood 2001;97(7):2091-7.
2001: Hofmann W K; Miller C W; Tsukasaki K; Tavor S; Ikezoe T; Hoelzer D; Takeuchi S; Koeffler H P
Mutation analysis of the DNA-damage checkpoint gene CHK2 in myelodysplastic syndromes and acute myeloid leukemias.
Leukemia research 2001;25(4):333-8.
2001: Verbeek W; Wächter M; Lekstrom-Himes J; Koeffler H P
C/EBPepsilon -/- mice: increased rate of myeloid proliferation and apoptosis.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2001;15(1):103-11.
2001: Müller-Tidow C; Metzger R; Kügler K; Diederichs S; Idos G; Thomas M; Dockhorn-Dworniczak B; Schneider P M; Koeffler H P; Berdel W E; Serve H
Cyclin E is the only cyclin-dependent kinase 2-associated cyclin that predicts metastasis and survival in early stage non-small cell lung cancer.
Cancer research 2001;61(2):647-53.
2000: Kubota T; Kawano S; Chih D Y; Hisatake Y; Chumakov A M; Taguchi H; Koeffler H P
Representational difference analysis using myeloid cells from C/EBP epsilon deletional mice.
Blood 2000;96(12):3953-7.
2000: Müller C; Yang R; Park D J; Serve H; Berdel W E; Koeffler H P
The aberrant fusion proteins PML-RAR alpha and PLZF-RAR alpha contribute to the overexpression of cyclin A1 in acute promyelocytic leukemia.
Blood 2000;96(12):3894-9.
2000: Ikezoe T; Daar E S; Hisatake J; Taguchi H; Koeffler H P
HIV-1 protease inhibitors decrease proliferation and induce differentiation of human myelocytic leukemia cells.
Blood 2000;96(10):3553-9.
2000: Campbell M J; Gombart A F; Kwok S H; Park S; Koeffler H P
The anti-proliferative effects of 1alpha,25(OH)2D3 on breast and prostate cancer cells are associated with induction of BRCA1 gene expression.
Oncogene 2000;19(44):5091-7.
2000: Hisatake J I; Ikezoe T; Carey M; Holden S; Tomoyasu S; Koeffler H P
Down-Regulation of prostate-specific antigen expression by ligands for peroxisome proliferator-activated receptor gamma in human prostate cancer.
Cancer research 2000;60(19):5494-8.
2000: Norman A W; Manchand P S; Uskokovic M R; Okamura W H; Takeuchi J A; Bishop J E; Hisatake J I; Koeffler H P; Peleg S
Characterization of a novel analogue of 1alpha,25(OH)(2)-vitamin D(3) with two side chains: interaction with its nuclear receptor and cellular actions.
Journal of medicinal chemistry 2000;43(14):2719-30.
2000: Mori N; Morosetti R; Hoflehner E; Lübbert M; Mizoguchi H; Koeffler H P
Allelic loss in the progression of myelodysplastic syndrome.
Cancer research 2000;60(11):3039-42.
2000: Kawabata H; Germain R S; Vuong P T; Nakamaki T; Said J W; Koeffler H P
Transferrin receptor 2-alpha supports cell growth both in iron-chelated cultured cells and in vivo.
The Journal of biological chemistry 2000;275(22):16618-25.
2000: Xie D; Hofmann W K; Mori N; Miller C W; Hoelzer D; Koeffler H P
Allelotype analysis of the myelodysplastic syndrome.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2000;14(5):805-10.
2000: Müller C; Readhead C; Diederichs S; Idos G; Yang R; Tidow N; Serve H; Berdel W E; Koeffler H P
Methylation of the cyclin A1 promoter correlates with gene silencing in somatic cell lines, while tissue-specific expression of cyclin A1 is methylation independent.
Molecular and cellular biology 2000;20(9):3316-29.
2000: Smith E A; Frankenburg E P; Goldstein S A; Koshizuka K; Elstner E; Said J; Kubota T; Uskokovic M; Koeffler H P
Effects of long-term administration of vitamin D3 analogs to mice.
The Journal of endocrinology 2000;165(1):163-72.
2000: Komatsu N; Takeuchi S; Ikezoe T; Tasaka T; Hatta Y; Machida H; Williamson I K; Bartram C R; Koeffler H P; Taguchi H
Mutations of the E2F4 gene in hematological malignancies having microsatellite instability.
Blood 2000;95(4):1509-10.
2000: Chumakov A M; Chumakova E A; Chih D; Koeffler H P
Molecular analysis of the human myeloperoxidase promoter region.
International journal of oncology 2000;16(2):401-11.
2000: Seol J G; Park W H; Kim E S; Jung C W; Binderup L; Koeffler H P; Kim B K; Lee Y Y
Effect of a novel vitamin D3 analog, EB1089, on G1 cell cycle regulatory proteins in HL-60 cells.
International journal of oncology 2000;16(2):315-20.
2000: Kubota T; Hisatake J; Hisatake Y; Said J W; Chen S S; Holden S; Taguchi H; Koeffler H P
PC-SPES: a unique inhibitor of proliferation of prostate cancer cells in vitro and in vivo .
The Prostate 2000;42(3):163-71.
2000: Koshiuka K; Elstner E; Williamson E; Said J W; Tada Y; Koeffler H P
Novel therapeutic approach: organic arsenical melarsoprol) alone or with all-trans-retinoic acid markedly inhibit growth of human breast and prostate cancer cells in vitro and in vivo.
British journal of cancer 2000;82(2):452-8.
2000: Asou H; Tasaka T; Said J W; Daibata M; Kamada N; Koeffler H P
Co-infection of HHV-6 and HHV-8 is rare in primary effusion lymphoma.
Leukemia research 2000;24(1):59-61.
1999: Takeuchi S; Cho S K; Seriu T; Koike M; Bartram C R; Reiter A; Schrappe M; Takeuchi C; Taguchi H; Koeffler H P
Identification of three distinct regions of deletion on the long arm of chromosome 11 in childhood acute lymphoblastic leukemia.
Oncogene 1999;18(51):7387-8.
1999: Müller C; Yang R; Idos G; Tidow N; Diederichs S; Koch O M; Verbeek W; Bender T P; Koeffler H P
c-myb transactivates the human cyclin A1 promoter and induces cyclin A1 gene expression.
Blood 1999;94(12):4255-62.
1999: Verbeek W; Lekstrom-Himes J; Park D J; Dang P M; Vuong P T; Kawano S; Babior B M; Xanthopoulos K; Koeffler H P
Myeloid transcription factor C/EBPepsilon is involved in the positive regulation of lactoferrin gene expression in neutrophils.
Blood 1999;94(9):3141-50.
1999: Asou H; Verbeek W; Williamson E; Elstner E; Kubota T; Kamada N; Koeffler H P
Growth inhibition of myeloid leukemia cells by troglitazone, a ligand for peroxisome proliferator activated receptor gamma, and retinoids.
International journal of oncology 1999;15(5):1027-31.
1999: Hisatake J; Kubota T; Hisatake Y; Uskokovic M; Tomoyasu S; Koeffler H P
5,6-trans-16-ene-vitamin D3: a new class of potent inhibitors of proliferation of prostate, breast, and myeloid leukemic cells.
Cancer research 1999;59(16):4023-9.
1999: Kawano S; Miller C W; Gombart A F; Bartram C R; Matsuo Y; Asou H; Sakashita A; Said J; Tatsumi E; Koeffler H P
Loss of p73 gene expression in leukemias/lymphomas due to hypermethylation.
Blood 1999;94(3):1113-20.
1999: Elstner E; Campbell M J; Munker R; Shintaku P; Binderup L; Heber D; Said J; Koeffler H P
Novel 20-epi-vitamin D3 analog combined with 9-cis-retinoic acid markedly inhibits colony growth of prostate cancer cells.
The Prostate 1999;40(3):141-9.
1999: Hirama T; Miller C W; Koeffler H P
Translocon-associated protein alpha transcripts are induced by granulocyte-macrophage colony-stimulating factor and exhibit complex alternative polyadenylation.
FEBS letters 1999;455(3):223-7.
1999: Kawabata H; Yang R; Hirama T; Vuong P T; Kawano S; Gombart A F; Koeffler H P
Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family.
The Journal of biological chemistry 1999;274(30):20826-32.
1999: Koike M; Koshizuka K; Kawabata H; Yang R; Taub H E; Said J; Uskokovic M; Tsuruoka N; Koeffler H P
20-Cyclopropyl-cholecalciferol vitamin D3 analogs: a unique class of potent inhibitors of proliferation of human prostate, breast and myeloid leukemia cell lines.
Anticancer research 1999;19(3A):1689-97.
1999: Park D J; Chumakov A M; Vuong P T; Chih D Y; Gombart A F; Miller W H; Koeffler H P
CCAAT/enhancer binding protein epsilon is a potential retinoid target gene in acute promyelocytic leukemia treatment.
The Journal of clinical investigation 1999;103(10):1399-408.
1999: Verbeek W; Gombart A F; Chumakov A M; Müller C; Friedman A D; Koeffler H P
C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters.
Blood 1999;93(10):3327-37.
1999: Müller C; Yang R; Beck-von-Peccoz L; Idos G; Verbeek W; Koeffler H P
Cloning of the cyclin A1 genomic structure and characterization of the promoter region. GC boxes are essential for cell cycle-regulated transcription of the cyclin A1 gene.
The Journal of biological chemistry 1999;274(16):11220-8.
1999: Said J W; Shintaku I P; Asou H; deVos S; Baker J; Hanson G; Cesarman E; Nador R; Koeffler H P
Herpesvirus 8 inclusions in primary effusion lymphoma: report of a unique case with T-cell phenotype.
Archives of pathology & laboratory medicine 1999;123(3):257-60.
1999: Koike M; Tasaka T; Spira S; Tsuruoka N; Koeffler H P
Allelotyping of acute myelogenous leukemia: loss of heterozygosity at 7q31.1 (D7S486) and q33-34 (D7S498, D7S505).
Leukemia research 1999;23(3):307-10.
1999: Yang R; Nakamaki T; Lübbert M; Said J; Sakashita A; Freyaldenhoven B S; Spira S; Huynh V; Müller C; Koeffler H P
Cyclin A1 expression in leukemia and normal hematopoietic cells.
Blood 1999;93(6):2067-74.
1999: Shiohara M; Dawson M I; Hobbs P D; Sawai N; Higuchi T; Koike K; Komiyama A; Koeffler H P
Effects of novel RAR- and RXR-selective retinoids on myeloid leukemic proliferation and differentiation in vitro.
Blood 1999;93(6):2057-66.
1999: Yang R; Müller C; Huynh V; Fung Y K; Yee A S; Koeffler H P
Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins.
Molecular and cellular biology 1999;19(3):2400-7.
1999: Campbell M J; Park S; Uskokovic M R; Dawson M I; Jong L; Koeffler H P
Synergistic inhibition of prostate cancer cell lines by a 19-nor hexafluoride vitamin D3 analogue and anti-activator protein 1 retinoid.
British journal of cancer 1999;79(1):101-7.
1999: Koshizuka K; Koike M; Asou H; Cho S K; Stephen T; Rude R K; Binderup L; Uskokovic M; Koeffler H P
Combined effect of vitamin D3 analogs and paclitaxel on the growth of MCF-7 breast cancer cells in vivo.
Breast cancer research and treatment 1999;53(2):113-20.
1999: Koshizuka K; Kubota T; Said J; Koike M; Binderup L; Uskokovic M; Koeffler H P
Combination therapy of a vitamin D3 analog and all-trans-retinoic acid: effect on human breast cancer in nude mice.
Anticancer research 1999;19(1A):519-24.
1999: Hatta Y; Yamada Y; Tomonaga M; Miyoshi I; Said J W; Koeffler H P
Detailed deletion mapping of the long arm of chromosome 6 in adult T-cell leukemia.
Blood 1999;93(2):613-6.
1998: Takeuchi S; Koike M; Park S; Seriu T; Bartram C R; Taub H E; Williamson I K; Grewal J; Taguchi H; Koeffler H P
The ATM gene and susceptibility to childhood T-cell acute lymphoblastic leukaemia.
British journal of haematology 1998;103(2):536-8.
1998: Mori N; Morosetti R; Spira S; Lee S; Ben-Yehuda D; Schiller G; Landolfi R; Mizoguchi H; Koeffler H P
Chromosome band 1p36 contains a putative tumor suppressor gene important in the evolution of chronic myelocytic leukemia.
Blood 1998;92(9):3405-9.
1998: Asou H; Koike M; Elstner E; Cambell M; Le J; Uskokovic M R; Kamada N; Koeffler H P
19-nor vitamin-D analogs: a new class of potent inhibitors of proliferation and inducers of differentiation of human myeloid leukemia cell lines.
Blood 1998;92(7):2441-9.
1998: Hatta Y; Yamada Y; Tomonaga M; Said J W; Miyosi I; Koeffler H P
Allelotype analysis of adult T-cell leukemia.
Blood 1998;92(6):2113-7.
1998: Koshizuka K; Koike M; Kubota T; Said J; Binderup L; Koeffler H P
Novel vitamin D3 analog (CB1093) when combined with paclitaxel and cisplatin inhibit growth of MCF-7 human breast cancer cells in vivo.
International journal of oncology 1998;13(3):421-8.
1998: Kubota T; Koshizuka K; Koike M; Uskokovic M; Miyoshi I; Koeffler H P
19-nor-26,27-bishomo-vitamin D3 analogs: a unique class of potent inhibitors of proliferation of prostate, breast, and hematopoietic cancer cells.
Cancer research 1998;58(15):3370-5.
1998: Kubota T; Koshizuka K; Williamson E A; Asou H; Said J W; Holden S; Miyoshi I; Koeffler H P
Ligand for peroxisome proliferator-activated receptor gamma (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo.
Cancer research 1998;58(15):3344-52.
1998: Elstner E; Müller C; Koshizuka K; Williamson E A; Park D; Asou H; Shintaku P; Said J W; Heber D; Koeffler H P
Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(15):8806-11.
1998: Takeuchi S; Koike M; Seriu T; Bartram C R; Schrappe M; Reiter A; Park S; Taub H E; Kubonishi I; Miyoshi I; Koeffler H P
Frequent loss of heterozygosity on the long arm of chromosome 6: identification of two distinct regions of deletion in childhood acute lymphoblastic leukemia.
Cancer research 1998;58(12):2618-23.
1998: Tasaka T; Asou H; Munker R; Said J W; Berenson J; Vescio R A; Nagai M; Takahara J; Koeffler H P
Methylation of the p16INK4A gene in multiple myeloma.
British journal of haematology 1998;101(3):558-64.
1998: Verbeek W; Frankel M; Miles S; Said J; Koeffler H P
Seroprevalence of HHV-8 antibodies in HIV-positive homosexual men without Kaposi's sarcoma and their clinical follow-up.
American journal of clinical pathology 1998;109(6):778-83.
1998: Williamson E A; Xu H N; Gombart A F; Verbeek W; Chumakov A M; Friedman A D; Koeffler H P
Identification of transcriptional activation and repression domains in human CCAAT/enhancer-binding protein epsilon.
The Journal of biological chemistry 1998;273(24):14796-804.
1998: Takeuchi S; Koeffler H P; Hinton D R; Miyoshi I; Melmed S; Shimon I
Mutation and expression analysis of the cyclin-dependent kinase inhibitor gene p27/Kip1 in pituitary tumors.
The Journal of endocrinology 1998;157(2):337-41.
1998: Hatta Y; Yamada Y; Tomonaga M; Miyoshi I; Said J W; Koeffler H P
Microsatellite instability in adult T-cell leukaemia.
British journal of haematology 1998;101(2):341-4.
1998: Campbell M J; Park S; Uskokovic M R; Dawson M I; Koeffler H P
Expression of retinoic acid receptor-beta sensitizes prostate cancer cells to growth inhibition mediated by combinations of retinoids and a 19-nor hexafluoride vitamin D3 analog.
Endocrinology 1998;139(4):1972-80.
1998: Asou H; Said J W; Yang R; Munker R; Park D J; Kamada N; Koeffler H P
Mechanisms of growth control of Kaposi's sarcoma-associated herpes virus-associated primary effusion lymphoma cells.
Blood 1998;91(7):2475-81.
1998: de Vos S; Kohn D B; Cho S K; McBride W H; Said J W; Koeffler H P
Immunotherapy against murine leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1998;12(3):401-5.
1998: Campbell M J; Dawson M; Koeffler H P
Growth inhibition of DU-145 prostate cancer cells by a Bcl-2 antisense oligonucleotide is enhanced by N-(2-hydroxyphenyl)all-trans retinamide.
British journal of cancer 1998;77(5):739-44.
1997: Hatta Y; Spirin K; Tasaka T; Morosetti R; Said J W; Yamada Y; Tomonaga M; Koeffler H P
Analysis of p18INK4C in adult T-cell leukaemia and non-Hodgkin's lymphoma.
British journal of haematology 1997;99(3):665-7.
1997: Munker R; Tasaka T; Park D; Miller C W; Koeffler H P
HHV-8 (KSHV) does not establish latency in prostate cancer cell lines.
The Prostate 1997;33(4):286-8.
1997: Said J W; Rettig M R; Heppner K; Vescio R A; Schiller G; Ma H J; Belson D; Savage A; Shintaku I P; Koeffler H P; Asou H; Pinkus G; Pinkus J; Schrage M; Green E; Berenson J R
Localization of Kaposi's sarcoma-associated herpesvirus in bone marrow biopsy samples from patients with multiple myeloma.
Blood 1997;90(11):4278-82.
1997: Koike M; Elstner E; Campbell M J; Asou H; Uskokovic M; Tsuruoka N; Koeffler H P
19-nor-hexafluoride analogue of vitamin D3: a novel class of potent inhibitors of proliferation of human breast cell lines.
Cancer research 1997;57(20):4545-50.
1997: Chih D Y; Chumakov A M; Park D J; Silla A G; Koeffler H P
Modulation of mRNA expression of a novel human myeloid-selective CCAAT/enhancer binding protein gene (C/EBP epsilon).
Blood 1997;90(8):2987-94.
1997: Morosetti R; Park D J; Chumakov A M; Grillier I; Shiohara M; Gombart A F; Nakamaki T; Weinberg K; Koeffler H P
A novel, myeloid transcription factor, C/EBP epsilon, is upregulated during granulocytic, but not monocytic, differentiation.
Blood 1997;90(7):2591-600.
1997: Takeuchi S; Koike M; Seriu T; Bartram C R; Slater J; Park S; Miyoshi I; Koeffler H P
Homozygous deletions at 9p21 in childhood acute lymphoblastic leukemia detected by microsatellite analysis.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1997;11(10):1636-40.
1997: Koike M; Chumakov A M; Takeuchi S; Tasaka T; Yang R; Nakamaki T; Tsuruoka N; Koeffler H P
C/EBP-epsilon: chromosomal mapping and mutational analysis of the gene in leukemia and preleukemia.
Leukemia research 1997;21(9):833-9.
1997: Shiohara M; Gombart A F; Berman J D; Koike K; Komiyama A; Koeffler H P
Cytostatic effect of TNFalpha on cancer cells is independent of p21WAF1.
Oncogene 1997;15(13):1605-9.
1997: Verbeek W; Gombart A F; Shiohara M; Campbell M; Koeffler H P
Vitamin D receptor: no evidence for allele-specific mRNA stability in cells which are heterozygous for the Taq I restriction enzyme polymorphism.
Biochemical and biophysical research communications 1997;238(1):77-80.
1997: Mori N; Morosetti R; Lee S; Spira S; Ben-Yehuda D; Schiller G; Landolfi R; Mizoguchi H; Koeffler H P
Allelotype analysis in the evolution of chronic myelocytic leukemia.
Blood 1997;90(5):2010-4.
1997: Campbell M J; Reddy G S; Koeffler H P
Vitamin D3 analogs and their 24-oxo metabolites equally inhibit clonal proliferation of a variety of cancer cells but have differing molecular effects.
Journal of cellular biochemistry 1997;66(3):413-25.
1997: Nagai M; Fujita M; Ohmori M; Matsubara S; Taniwaki M; Horiike S; Tasaka T; Koeffler H P; Takahara J
Establishment of a novel human B-cell line (OZ) with t(14;18)(q32;q21) and aberrant p53 expression was associated with the homozygous deletions of p15INK4B and p16INK4A genes.
Hematological oncology 1997;15(3):109-19.
1997: Miller C W; Morosetti R; Campbell M J; Mendoza S; Koeffler H P
Integrity of the 1,25-dihydroxyvitamin D3 receptor in bone, lung, and other cancers.
Molecular carcinogenesis 1997;19(4):254-7.
1997: Campbell M J; Elstner E; Holden S; Uskokovic M; Koeffler H P
Inhibition of proliferation of prostate cancer cells by a 19-nor-hexafluoride vitamin D3 analogue involves the induction of p21waf1, p27kip1 and E-cadherin.
Journal of molecular endocrinology 1997;19(1):15-27.
1997: Takeuchi S; Seriu T; Bartram C R; Golub T R; Reiter A; Miyoshi I; Gilliland D G; Koeffler H P
TEL is one of the targets for deletion on 12p in many cases of childhood B-lineage acute lymphoblastic leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1997;11(8):1220-3.
1997: Said J W; Chien K; Tasaka T; Koeffler H P
Ultrastructural characterization of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) in Kaposi's sarcoma lesions: electron microscopy permits distinction from cytomegalovirus (CMV).
The Journal of pathology 1997;182(3):273-81.
1997: Miller C W; Yeon C; Aslo A; Mendoza S; Aytac U; Koeffler H P
The p19INK4D cyclin dependent kinase inhibitor gene is altered in osteosarcoma.
Oncogene 1997;15(2):231-5.
1997: Tasaka T; Lee S; Spira S; Takeuchi S; Nagai M; Takahara J; Koeffler H P
Microsatellite instability during the progression of acute myelocytic leukaemia.
British journal of haematology 1997;98(1):219-21.
1997: Takeuchi S; Seriu T; Tasaka T; Koike M; Cho S K; Park S; Slater J; Mufti I; Hatta Y; Miyoshi I; Bartram C R; Koeffler H P
Microsatellite instability and other molecular abnormalities in childhood acute lymphoblastic leukaemia.
British journal of haematology 1997;98(1):134-9.
1997: de Vos S; Dawson M I; Holden S; Le T; Wang A; Cho S K; Chen D L; Koeffler H P
Effects of retinoid X receptor-selective ligands on proliferation of prostate cancer cells.
The Prostate 1997;32(2):115-21.
1997: Hatta Y; Yamada Y; Tomonaga M; Koeffler H P
Extensive analysis of the retinoblastoma gene in adult T cell leukemia/lymphoma (ATL).
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1997;11(7):984-9.
1997: Shiohara M; Koike K; Komiyama A; Koeffler H P
p21WAF1 mutations and human malignancies.
Leukemia & lymphoma 1997;26(1-2):35-41.
1997: de Vos S; Holden S; Heber D; Elstner E; Binderup L; Uskokovic M; Rude B; Chen D L; Le J; Cho S K; Koeffler H P
Effects of potent vitamin D3 analogs on clonal proliferation of human prostate cancer cell lines.
The Prostate 1997;31(2):77-83.
1997: Koike M; Takeuchi S; Yokota J; Park S; Hatta Y; Miller C W; Tsuruoka N; Koeffler H P
Frequent loss of heterozygosity in the region of the D7S523 locus in advanced ovarian cancer.
Genes, chromosomes & cancer 1997;19(1):1-5.
1997: Park D J; Wilczynski S P; Pham E Y; Miller C W; Koeffler H P
Molecular analysis of the INK4 family of genes in prostate carcinomas.
The Journal of urology 1997;157(5):1995-9.
1997: Miller C W; Koeffler H P
Cyclin-dependent kinase inhibitors in human neoplasms.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1997;11 Suppl 3():370-1.
1997: Nakamaki T; Bartram C; Seriu T; Kahan J; Fukuchi K; Tsuruoka N; Janssen J W; Miller C W; Koeffler H P
Molecular analysis of the cyclin-dependent kinase inhibitor genes, p15, p16, p18 and p19 in the myelodysplastic syndromes.
Leukemia research 1997;21(3):235-40.
1997: Grillier I; Umiel T; Elstner E; Collins S J; Koeffler H P
Alterations of differentiation, clonal proliferation, cell cycle progression and bcl-2 expression in RAR alpha-altered sublines of HL-60.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1997;11(3):393-400.
1997: Tasaka T; Said J W; Morosetti R; Park D; Verbeek W; Nagai M; Takahara J; Koeffler H P
Is Kaposi's sarcoma--associated herpesvirus ubiquitous in urogenital and prostate tissues?
Blood 1997;89(5):1686-9.
1997: Yang R; Morosetti R; Koeffler H P
Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines.
Cancer research 1997;57(5):913-20.
1997: Chumakov A M; Grillier I; Chumakova E; Chih D; Slater J; Koeffler H P
Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor.
Molecular and cellular biology 1997;17(3):1375-86.
1997: Wada M; Miller C W; Yokota J; Lee E; Mizoguchi H; Koeffler H P
Molecular analysis of the adenomatous polyposis coli gene in sarcomas, hematological malignancies and noncolonic, neoplastic tissues.
Journal of molecular medicine (Berlin, Germany) 1997;75(2):139-44.
1997: Kawamata N; Seriu T; Bartram C R; Koeffler H P
Molecular analysis of the secretory phospholipase A2 gene, a candidate of Mom1 gene, in neuroblastomas.
Cancer letters 1997;111(1-2):71-5.
1997: Tasaka T; Berenson J; Vescio R; Hirama T; Miller C W; Nagai M; Takahara J; Koeffler H P
Analysis of the p16INK4A, p15INK4B and p18INK4C genes in multiple myeloma.
British journal of haematology 1997;96(1):98-102.
1997: Elstner E; Linker-Israeli M; Le J; Umiel T; Michl P; Said J W; Binderup L; Reed J C; Koeffler H P
Synergistic decrease of clonal proliferation, induction of differentiation, and apoptosis of acute promyelocytic leukemia cells after combined treatment with novel 20-epi vitamin D3 analogs and 9-cis retinoic acid.
The Journal of clinical investigation 1997;99(2):349-60.
1997: Mori N; Takeuchi S; Tasaka T; Lee S; Spira S; Ben-Yehuda D; Mizoguchi H; Schiller G; Koeffler H P
Absence of microsatellite instability during the progression of chronic myelocytic leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1997;11(1):151-2.
1997: Hatta Y; Takeuchi S; Yokota J; Koeffler H P
Ovarian cancer has frequent loss of heterozygosity at chromosome 12p12.3-13.1 (region of TEL and Kip1 loci) and chromosome 12q23-ter: evidence for two new tumour-suppressor genes.
British journal of cancer 1997;75(9):1256-62.
1996: Shiohara M; Spirin K; Said J W; Gombart A F; Nakamaki T; Takeuchi S; Hatta Y; Morosetti R; Tasaka T; Seriu T; Bartram C; Miller C W; Tomonaga M; Koeffler H P
Alterations of the cyclin-dependent kinase inhibitor p19 (INK4D) is rare in hematopoietic malignancies.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1996;10(12):1897-900.
1996: Said J W; Tasaka T; Takeuchi S; Asou H; de Vos S; Cesarman E; Knowles D M; Koeffler H P
Primary effusion lymphoma in women: report of two cases of Kaposi's sarcoma herpes virus-associated effusion-based lymphoma in human immunodeficiency virus-negative women.
Blood 1996;88(8):3124-8.
1996: Kawamata N; Park D; Wilczynski S; Yokota J; Koeffler H P
Point mutations of the Mxil gene are rare in prostate cancers.
The Prostate 1996;29(3):191-3.
1996: Munker R; Kobayashi T; Elstner E; Norman A W; Uskokovic M; Zhang W; Andreeff M; Koeffler H P
A new series of vitamin D analogs is highly active for clonal inhibition, differentiation, and induction of WAF1 in myeloid leukemia.
Blood 1996;88(6):2201-9.
1996: Elstner E; Linker-Israeli M; Umiel T; Le J; Grillier I; Said J; Shintaku I P; Krajewski S; Reed J C; Binderup L; Koeffler H P
Combination of a potent 20-epi-vitamin D3 analogue (KH 1060) with 9-cis-retinoic acid irreversibly inhibits clonal growth, decreases bcl-2 expression, and induces apoptosis in HL-60 leukemic cells.
Cancer research 1996;56(15):3570-6.
1996: Park D J; Koeffler H P
Therapy-related myelodysplastic syndromes.
Seminars in hematology 1996;33(3):256-73.
1996: Morosetti R; Koeffler H P
Differentiation therapy in myelodysplastic syndromes.
Seminars in hematology 1996;33(3):236-45.
1996: Ishiguro A; Spirin K S; Shiohara M; Tobler A; Gombart A F; Israel M A; Norton J D; Koeffler H P
Id2 expression increases with differentiation of human myeloid cells.
Blood 1996;87(12):5225-31.
1996: Said W; Chien K; Takeuchi S; Tasaka T; Asou H; Cho S K; de Vos S; Cesarman E; Knowles D M; Koeffler H P
Kaposi's sarcoma-associated herpesvirus (KSHV or HHV8) in primary effusion lymphoma: ultrastructural demonstration of herpesvirus in lymphoma cells.
Blood 1996;87(12):4937-43.
1996: Park D J; Chumakov A M; Miller C W; Pham E Y; Koeffler H P
p53 transactivation through various p53-responsive elements.
Molecular carcinogenesis 1996;16(2):101-8.
1996: Moore T B; Koeffler H P; Yamashiro J M; Wada R K
Vitamin D3 analogs inhibit growth and induce differentiation in LA-N-5 human neuroblastoma cells.
Clinical & experimental metastasis 1996;14(3):239-45.
1996: Morosetti R; Grignani F; Liberatore C; Pelicci P G; Schiller G J; Kizaki M; Bartram C R; Miller C W; Koeffler H P
Infrequent alterations of the RAR alpha gene in acute myelogenous leukemias, retinoic acid-resistant acute promyelocytic leukemias, myelodysplastic syndromes, and cell lines.
Blood 1996;87(10):4399-403.
1996: Spirin K S; Simpson J F; Takeuchi S; Kawamata N; Miller C W; Koeffler H P
p27/Kip1 mutation found in breast cancer.
Cancer research 1996;56(10):2400-4.
1996: Koeffler H P
Myelodysplastic syndromes.
Seminars in hematology 1996;33(2):87-94.
1996: Takeuchi S; Bartram C R; Miller C W; Reiter A; Seriu T; Zimmerann M; Schrappe M; Mori N; Slater J; Miyoshi I; Koeffler H P
Acute lymphoblastic leukemia of childhood: identification of two distinct regions of deletion on the short arm of chromosome 12 in the region of TEL and KIP1.
Blood 1996;87(8):3368-74.
1996: Kawamata N; Miller C; Levy V; Shintaku I P; Koeffler H P; Said J W
mdm-2 oncogene expression in non-Hodgkin's lymphomas.
Diagnostic molecular pathology : the American journal of surgical pathology, part B 1996;5(1):33-8.
1996: Levy V; Miller C; Koeffler H P; Said J W
p53 in lymphomas of mucosal-associated lymphoid tissues.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1996;9(3):245-8.
1996: Kizaki M; Dawson M I; Heyman R; Elster E; Morosetti R; Pakkala S; Chen D L; Ueno H; Chao W; Morikawa M; Ikeda Y; Heber D; Pfahl M; Koeffler H P
Effects of novel retinoid X receptor-selective ligands on myeloid leukemia differentiation and proliferation in vitro.
Blood 1996;87(5):1977-84.
1996: Shiohara M; Akashi M; Gombart A F; Yang R; Koeffler H P
Tumor necrosis factor alpha: posttranscriptional stabilization of WAF1 mRNA in p53-deficient human leukemic cells.
Journal of cellular physiology 1996;166(3):568-76.
1996: Takeuchi S; Mori N; Koike M; Slater J; Park S; Miller C W; Miyoshi I; Koeffler H P
Frequent loss of heterozygosity in region of the KIP1 locus in non-small cell lung cancer: evidence for a new tumor suppressor gene on the short arm of chromosome 12.
Cancer research 1996;56(4):738-40.
1996: Kawamata N; Seriu T; Koeffler H P; Bartram C R
Molecular analysis of the cyclin-dependent kinase inhibitor family: p16(CDKN2/MTS1/INK4A), p18(INK4C) and p27(Kip1) genes in neuroblastomas.
Cancer 1996;77(3):570-5.
1996: Tasak T; Lee S; Spira S; Takeuchi S; Hatta Y; Nagai M; Takahara J; Koeffler H P
Infrequent microsatellite instability during the evolution of myelodysplastic syndrome to acute myelocytic leukemia.
Leukemia research 1996;20(2):113-7.
1996: Miller C W; Aslo A; Campbell M J; Kawamata N; Lampkin B C; Koeffler H P
Alterations of the p15, p16,and p18 genes in osteosarcoma.
Cancer genetics and cytogenetics 1996;86(2):136-42.
1996: Hirama T; Miller C W; Wilczynski S P; Koeffler H P
p16 (CDKN2/cyclin-dependent kinase-4 inhibitor/multiple tumor suppressor-1) gene is not altered in uterine cervical carcinomas or cell lines.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1996;9(1):26-31.
1996: Yang R; Serrano M; Slater J; Leung E; Koeffler H P
Analysis of p16INK4a and its interaction with CDK4.
Biochemical and biophysical research communications 1996;218(1):254-9.
1996: Kizaki M; Ueno H; Yamazoe Y; Shimada M; Takayama N; Muto A; Matsushita H; Nakajima H; Morikawa M; Koeffler H P; Ikeda Y
Mechanisms of retinoid resistance in leukemic cells: possible role of cytochrome P450 and P-glycoprotein.
Blood 1996;87(2):725-33.
1995: Ishiguro A; Spirin K; Shiohara M; Tobler A; Norton J D; Rigolet M; Shimbo T; Koeffler H P
Expression of Id2 and Id3 mRNA in human lymphocytes.
Leukemia research 1995;19(12):989-96.
1995: Kawamata N; Miller C W; Koeffler H P
Molecular analysis of a family of cyclin-dependent kinase inhibitor genes (p15/MTS2/INK4b and p18/INK4c) in non-small cell lung cancers.
Molecular carcinogenesis 1995;14(4):263-8.
1995: Nakamaki T; Imamura J; Brewer G; Tsuruoka N; Koeffler H P
Characterization of adenosine-uridine-rich RNA binding factors.
Journal of cellular physiology 1995;165(3):484-92.
1995: de Vos S; Miller C W; Takeuchi S; Gombart A F; Cho S K; Koeffler H P
Alterations of CDKN2 (p16) in non-small cell lung cancer.
Genes, chromosomes & cancer 1995;14(3):164-70.
1995: Takeuchi S; Bartram C R; Wada M; Reiter A; Hatta Y; Seriu T; Lee E; Miller C W; Miyoshi I; Koeffler H P
Allelotype analysis of childhood acute lymphoblastic leukemia.
Cancer research 1995;55(22):5377-82.
1995: Hatta Y; Hirama T; Takeuchi S; Lee E; Pham E; Miller C W; Strohmeyer T; Wilczynski S P; Melmed S; Koeffler H P
Alterations of the p16 (MTS1) gene in testicular, ovarian, and endometrial malignancies.
The Journal of urology 1995;154(5):1954-7.
1995: Morosétti R; Kawamata N; Gombart A F; Miller C W; Hatta Y; Hirama T; Said J W; Tomonaga M; Koeffler H P
Alterations of the p27KIP1 gene in non-Hodgkin's lymphomas and adult T-cell leukemia/lymphoma.
Blood 1995;86(5):1924-30.
1995: Gombart A F; Morosetti R; Miller C W; Said J W; Koeffler H P
Deletions of the cyclin-dependent kinase inhibitor genes p16INK4A and p15INK4B in non-Hodgkin's lymphomas.
Blood 1995;86(4):1534-9.
1995: Hirama T; Koeffler H P
Role of the cyclin-dependent kinase inhibitors in the development of cancer.
Blood 1995;86(3):841-54.
1995: Wada M; Seeger R C; Mizoguchi H; Koeffler H P
Maintenance of normal imprinting of H19 and IGF2 genes in neuroblastoma.
Cancer research 1995;55(15):3386-8.
1995: Elstner E; Linker-Israeli M; Said J; Umiel T; de Vos S; Shintaku I P; Heber D; Binderup L; Uskokovic M; Koeffler H P
20-epi-vitamin D3 analogues: a novel class of potent inhibitors of proliferation and inducers of differentiation of human breast cancer cell lines.
Cancer research 1995;55(13):2822-30.
1995: Yang R; Gombart A F; Serrano M; Koeffler H P
Mutational effects on the p16INK4a tumor suppressor protein.
Cancer research 1995;55(12):2503-6.
1995: Takeuchi S; Bartram C R; Ludwig R; Royer-Pokora B; Schneider S; Imamura J; Koeffler H P
Mutations of p53 in Wilms' tumors.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1995;8(5):483-7.
1995: Hatta Y; Hirama T; Miller C W; Yamada Y; Tomonaga M; Koeffler H P
Homozygous deletions of the p15 (MTS2) and p16 (CDKN2/MTS1) genes in adult T-cell leukemia.
Blood 1995;85(10):2699-704.
1995: Fleischhacker M; Lee S; Spira S; Takeuchi S; Koeffler H P
DNA aneuploidy in morphologically normal colons from patients with colon cancer.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1995;8(4):360-5.
1995: Imai Y; Pike J W; Koeffler H P
Potent vitamin D3 analogs: their abilities to enhance transactivation and to bind to the vitamin D3 response element.
Leukemia research 1995;19(3):147-58.
1995: de Vos S; Epstein C J; Carlson E; Cho S K; Koeffler H P
Transgenic mice overexpressing human copper/zinc-superoxide dismutase (Cu/Zn SOD) are not resistant to endotoxic shock.
Biochemical and biophysical research communications 1995;208(2):523-31.
1995: Pakkala S; de Vos S; Elstner E; Rude R K; Uskokovic M; Binderup L; Koeffler H P
Vitamin D3 analogs: effect on leukemic clonal growth and differentiation, and on serum calcium levels.
Leukemia research 1995;19(1):65-72.
1994: Shiohara M; el-Deiry W S; Wada M; Nakamaki T; Takeuchi S; Yang R; Chen D L; Vogelstein B; Koeffler H P
Absence of WAF1 mutations in a variety of human malignancies.
Blood 1994;84(11):3781-4.
1994: Elstner E; Lee Y Y; Hashiya M; Pakkala S; Binderup L; Norman A W; Okamura W H; Koeffler H P
1 alpha,25-Dihydroxy-20-epi-vitamin D3: an extraordinarily potent inhibitor of leukemic cell growth in vitro.
Blood 1994;84(6):1960-7.
1994: Hachiya M; Chumakov A; Miller C W; Akashi M; Said J; Koeffler H P
Mutant p53 proteins behave in a dominant, negative fashion in vivo.
Anticancer research 1994;14(5A):1853-9.
1994: Imai Y; Strohmeyer T G; Fleischhacker M; Slamon D J; Koeffler H P
p53 mutations and MDM-2 amplification in renal cell cancers.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1994;7(7):766-70.
1994: Sakashita A; Curnutte J T; Koeffler H P
Myeloid haemopoietic cells of patients with chronic granulomatous disease are relatively resistant to TNF.
British journal of haematology 1994;88(1):31-8.
1994: Sakashita A; Epstein C J; Carlson E; Koeffler H P
Hematopoietic progenitor cells of transgenic mice with increased copper/zinc-superoxide dismutase activity are resistant to tumor necrosis factor.
Journal of cellular physiology 1994;160(2):233-8.
1994: Giles F J; Koeffler H P
Secondary myelodysplastic syndromes and leukemias.
Current opinion in hematology 1994;1(4):256-60.
1994: Park D J; Nakamura H; Chumakov A M; Said J W; Miller C W; Chen D L; Koeffler H P
Transactivational and DNA binding abilities of endogenous p53 in p53 mutant cell lines.
Oncogene 1994;9(7):1899-906.
1994: Dawson M I; Elstner E; Kizaki M; Chen D L; Pakkala S; Kerner B; Koeffler H P
Myeloid differentiation mediated through retinoic acid receptor/retinoic X receptor (RXR) not RXR/RXR pathway.
Blood 1994;84(2):446-52.
1994: Jung S J; Lee Y Y; Pakkala S; de Vos S; Elstner E; Norman A W; Green J; Uskokovic M; Koeffler H P
1,25(OH)2-16ene-vitamin D3 is a potent antileukemic agent with low potential to cause hypercalcemia.
Leukemia research 1994;18(6):453-63.
1994: Kizaki M; Nakajima H; Mori S; Koike T; Morikawa M; Ohta M; Saito M; Koeffler H P; Ikeda Y
Novel retinoic acid, 9-cis retinoic acid, in combination with all-trans retinoic acid is an effective inducer of differentiation of retinoic acid-resistant HL-60 cells.
Blood 1994;83(11):3289-97.
1994: Lee Y Y; Wilczynski S P; Chumakov A; Chih D; Koeffler H P
Carcinoma of the vulva: HPV and p53 mutations.
Oncogene 1994;9(6):1655-9.
1994: Walts A E; Said J W; Koeffler H P
Is immunoreactivity for p53 useful in distinguishing benign from malignant effusions? Localization of p53 gene product in benign mesothelial and adenocarcinoma cells.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1994;7(4):462-8.
1994: Fleischhacker M; Strohmeyer T; Imai Y; Slamon D J; Koeffler H P
Mutations of the p53 gene are not detectable in human testicular tumors.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1994;7(4):435-9.
1994: Kizaki M; Miller C W; Selsted M E; Koeffler H P
Myeloperoxidase (MPO) gene mutation in hereditary MPO deficiency.
Blood 1994;83(7):1935-40.
1994: Park D J; Wilczynski S P; Paquette R L; Miller C W; Koeffler H P
p53 mutations in HPV-negative cervical carcinoma.
Oncogene 1994;9(1):205-10.
1993: Kizaki M; Ikeda Y; Tanosaki R; Nakajima H; Morikawa M; Sakashita A; Koeffler H P
Effects of novel retinoic acid compound, 9-cis-retinoic acid, on proliferation, differentiation, and expression of retinoic acid receptor-alpha and retinoid X receptor-alpha RNA by HL-60 cells.
Blood 1993;82(12):3592-9.
1993: Chumakov A M; Miller C W; Chen D L; Koeffler H P
Analysis of p53 transactivation through high-affinity binding sites.
Oncogene 1993;8(11):3005-11.
1993: Walts A E; Koeffler H P; Said J W
Localization of p53 protein and human papillomavirus in anogenital squamous lesions: immunohistochemical and in situ hybridization studies in benign, dysplastic, and malignant epithelia.
Human pathology 1993;24(11):1238-42.
1993: Kizaki M; Ikeda Y; Simon K J; Nanjo M; Koeffler H P
Effect of 1,25-dihydroxyvitamin D3 and its analogs on human immunodeficiency virus infection in monocytes/macrophages.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1993;7(10):1525-30.
1993: Selsted M E; Miller C W; Novotny M J; Morris W L; Koeffler H P
Molecular analysis of myeloperoxidase deficiency shows heterogeneous patterns of the complete deficiency state manifested at the genomic, mRNA, and protein levels.
Blood 1993;82(4):1317-22.
1993: Paquette R L; Lee Y Y; Wilczynski S P; Karmakar A; Kizaki M; Miller C W; Koeffler H P
Mutations of p53 and human papillomavirus infection in cervical carcinoma.
Cancer 1993;72(4):1272-80.
1993: Miller C; Koeffler H P
P53 mutations in human cancer.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1993;7 Suppl 2():S18-21.
1993: Kizaki M; Sakashita A; Karmakar A; Lin C W; Koeffler H P
Regulation of manganese superoxide dismutase and other antioxidant genes in normal and leukemic hematopoietic cells and their relationship to cytotoxicity by tumor necrosis factor.
Blood 1993;82(4):1142-50.
1993: Nakamura H; Said J W; Miller C W; Koeffler H P
Mutation and protein expression of p53 in acquired immunodeficiency syndrome-related lymphomas.
Blood 1993;82(3):920-6.
1993: Miller C W; Chumakov A; Said J; Chen D L; Aslo A; Koeffler H P
Mutant p53 proteins have diverse intracellular abilities to oligomerize and activate transcription.
Oncogene 1993;8(7):1815-24.
1993: Paquette R L; Landaw E M; Pierre R V; Kahan J; Lübbert M; Lazcano O; Isaac G; McCormick F; Koeffler H P
N-ras mutations are associated with poor prognosis and increased risk of leukemia in myelodysplastic syndrome.
Blood 1993;82(2):590-9.
1993: Chumakov A M; Chen D L; Chumakova E A; Koeffler H P
Localization of the c-ets-2 transactivation domain.
Journal of virology 1993;67(4):2421-5.
1993: Sakashita A; Kizaki M; Pakkala S; Schiller G; Tsuruoka N; Tomosaki R; Cameron J F; Dawson M I; Koeffler H P
9-cis-retinoic acid: effects on normal and leukemic hematopoiesis in vitro.
Blood 1993;81(4):1009-16.
1993: Fagin J A; Matsuo K; Karmakar A; Chen D L; Tang S H; Koeffler H P
High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas.
The Journal of clinical investigation 1993;91(1):179-84.
1992: Lee Y Y; Kurtz I; Yamato K; el-Hajjoui Z; Koeffler H P
Tumor necrosis factor stimulates Na+/H+ antiporter in human fibroblasts: dissociation between intracellular alkalinization and cytokine mRNA accumulation.
Blood 1992;79(9):2262-6.
1992: Miller C W; Simon K; Aslo A; Kok K; Yokota J; Buys C H; Terada M; Koeffler H P
p53 mutations in human lung tumors.
Cancer research 1992;52(7):1695-8.
1992: Kizaki M; Koeffler H P
Differentiation-inducing agents in the treatment of myelodysplastic syndromes.
Seminars in oncology 1992;19(1):95-105.
1992: Sakashita A; Hattori T; Miller C W; Suzushima H; Asou N; Takatsuki K; Koeffler H P
Mutations of the p53 gene in adult T-cell leukemia.
Blood 1992;79(2):477-80.
1991: Akashi M; Shaw G; Gross M; Saito M; Koeffler H P
Role of AUUU sequences in stabilization of granulocyte-macrophage colony-stimulating factor RNA in stimulated cells.
Blood 1991;78(8):2005-12.
1991: Figadère B; Norman A W; Henry H L; Koeffler H P; Zhou J Y; Okamura W H
Arocalciferols: synthesis and biological evaluation of aromatic side-chain analogues of 1 alpha,25-dihydroxyvitamin D3(1a).
Journal of medicinal chemistry 1991;34(8):2452-63.
1991: Lübbert M; Salser W; Prokocimer M; Miller C W; Thomason A; Koeffler H P
Stable methylation patterns of MYC and other genes regulated during terminal myeloid differentiation.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1991;5(7):533-9.
1991: Zhou J Y; Norman A W; Akashi M; Chen D L; Uskokovic M R; Aurrecoechea J M; Dauben W G; Okamura W H; Koeffler H P
Development of a novel 1,25(OH)2-vitamin D3 analog with potent ability to induce HL-60 cell differentiation without modulating calcium metabolism.
Blood 1991;78(1):75-82.
1991: Ross H J; Sato N; Ueyama Y; Koeffler H P
Cytokine messenger RNA stability is enhanced in tumor cells.
Blood 1991;77(8):1787-95.
1991: Kizaki M; Norman A W; Bishop J E; Lin C W; Karmakar A; Koeffler H P
1,25-Dihydroxyvitamin D3 receptor RNA: expression in hematopoietic cells.
Blood 1991;77(6):1238-47.
1991: Reichel H; Bishop J E; Koeffler H P; Norman A W
Evidence for 1,25-dihydroxyvitamin D3 production by cultured porcine alveolar macrophages.
Molecular and cellular endocrinology 1991;75(2):163-7.
1991: Yamato K; el-Hajjoui Z; Koeffler H P
Expression of hematopoietic growth factor RNAs in human mesenchymal cells from various organs.
Leukemia research 1991;15(7):551-8.
1991: Miyagi T; Akashi M; Yamato K; Miyoshi I; Koeffler H P
D-factor: modulation of expression in fibroblasts.
Leukemia research 1991;15(6):441-51.
1990: O'Rourke R W; Miller C W; Kato G J; Simon K J; Chen D L; Dang C V; Koeffler H P
A potential transcriptional activation element in the p53 protein.
Oncogene 1990;5(12):1829-32.
1990: Miller C W; Aslo A; Tsay C; Slamon D; Ishizaki K; Toguchida J; Yamamuro T; Lampkin B; Koeffler H P
Frequency and structure of p53 rearrangements in human osteosarcoma.
Cancer research 1990;50(24):7950-4.
1990: Paquette R L; Berenson J; Lichtenstein A; McCormick F; Koeffler H P
Oncogenes in multiple myeloma: point mutation of N-ras.
Oncogene 1990;5(11):1659-63.
1990: Norman A W; Zhou J Y; Henry H L; Uskokovic M R; Koeffler H P
Structure-function studies on analogues of 1 alpha,25-dihydroxyvitamin D3: differential effects on leukemic cell growth, differentiation, and intestinal calcium absorption.
Cancer research 1990;50(21):6857-64.
1990: Yamato K; el-Hajjaoui Z; Simon K; Koeffler H P
Modulation of interleukin-1 beta RNA in monocytic cells infected with human immunodeficiency virus-1.
The Journal of clinical investigation 1990;86(4):1109-14.
1990: Zhou J Y; Norman A W; Chen D L; Sun G W; Uskokovic M; Koeffler H P
1,25-Dihydroxy-16-ene-23-yne-vitamin D3 prolongs survival time of leukemic mice.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(10):3929-32.
1990: Sun G X; Koeffler H P; Gale R P; Sparkes R S; Schreck R R
Use of conditioned media in cell culture can mask cytogenetic abnormalities in acute leukemia.
Cancer genetics and cytogenetics 1990;46(1):107-13.
1990: Zhou J Y; Chen D L; Shen Z S; Koeffler H P
Effect of homoharringtonine on proliferation and differentiation of human leukemic cells in vitro.
Cancer research 1990;50(7):2031-5.
1990: Lübbert M; Jonas D; Miller C W; Herrmann F; Mertelsmann R; McCormick F; Koeffler H P
Retrospective analysis of ras gene activation in myeloid leukemic cells.
Oncogene 1990;5(4):583-7.
1990: Lübbert M; Mirro J; Miller C W; Kahan J; Isaac G; Kitchingman G; Mertelsmann R; Herrmann F; McCormick F; Koeffler H P
N-ras gene point mutations in childhood acute lymphocytic leukemia correlate with a poor prognosis.
Blood 1990;75(5):1163-9.
1990: Koeffler H P; Bishop J E; Reichel H; Singer F; Nagler A; Tobler A; Walka M; Norman A W
Lymphocyte cell lines from vitamin D-dependent rickets type II show functional defects in the 1 alpha,25-dihydroxyvitamin D3 receptor.
Molecular and cellular endocrinology 1990;70(1):1-11.
1990: Akashi M; Loussararian A H; Adelman D C; Saito M; Koeffler H P
Role of lymphotoxin in expression of interleukin 6 in human fibroblasts. Stimulation and regulation.
The Journal of clinical investigation 1990;85(1):121-9.
1990: Akashi M; Koeffler H P
Control of hematopoietic growth factors.
Progress in clinical and biological research 1990;352():257-67.
1990: Reichel H; Koeffler H P; Norman A W
Production of 1 alpha,25-dihydroxyvitamin D3 by hematopoietic cells.
Progress in clinical and biological research 1990;332():81-97.
1990: Kizaki M; Koeffler H P; Lin C W; Miller C W
Expression of retinoic acid receptor mRNA in hematopoietic cells.
Leukemia research 1990;14(7):645-55.
1989: Akashi M; Saito M; Koeffler H P
Lymphotoxin: stimulation and regulation of colony-stimulating factors in fibroblasts.
Blood 1989;74(7):2383-90.
1989: Nimer S D; Gates M J; Koeffler H P; Gasson J C
Multiple mechanisms control the expression of granulocyte-macrophage colony-stimulating factor by human fibroblasts.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(7):2374-7.
1989: Yamato K; El-Hajjaoui Z; Kuo J F; Koeffler H P
Granulocyte-macrophage colony-stimulating factor: signals for its mRNA accumulation.
Blood 1989;74(4):1314-20.
1989: Zhou J Y; Norman A W; Lübbert M; Collins E D; Uskokovic M R; Koeffler H P
Novel vitamin D analogs that modulate leukemic cell growth and differentiation with little effect on either intestinal calcium absorption or bone mobilization.
Blood 1989;74(1):82-93.
1989: Yamato K; el-Hajjaoui Z; Koeffler H P
Regulation of levels of IL-1 mRNA in human fibroblasts.
Journal of cellular physiology 1989;139(3):610-6.
1989: Lübbert M; Miller C W; Kahan J; Koeffler H P
Expression, methylation and chromatin structure of the p53 gene in untransformed and human T-cell leukemia virus type I-transformed human T-lymphocytes.
Oncogene 1989;4(5):643-51.
1989: Tobler A; Selsted M E; Miller C W; Johnson K R; Novotny M J; Rovera G; Koeffler H P
Evidence for a pretranslational defect in hereditary and acquired myeloperoxidase deficiency.
Blood 1989;73(7):1980-6.
1988: Tobler A; Miller C W; Johnson K R; Selsted M E; Rovera G; Koeffler H P
Regulation of gene expression of myeloperoxidase during myeloid differentiation.
Journal of cellular physiology 1988;136(2):215-25.
1988: Koeffler H P; Gasson J; Tobler A
Transcriptional and posttranscriptional modulation of myeloid colony-stimulating factor expression by tumor necrosis factor and other agents.
Molecular and cellular biology 1988;8(8):3432-8.
1988: Tobler A; Miller C W; Norman A W; Koeffler H P
1,25-Dihydroxyvitamin D3 modulates the expression of a lymphokine (granulocyte-macrophage colony-stimulating factor) posttranscriptionally.
The Journal of clinical investigation 1988;81(6):1819-23.
1988: Paquette R L; Zhou J Y; Yang Y C; Clark S C; Koeffler H P
Recombinant gibbon interleukin-3 acts synergistically with recombinant human G-CSF and GM-CSF in vitro.
Blood 1988;71(6):1596-600.
1988: Sidell N; Koeffler H P
Modulation of Mr 53,000 protein with induction of differentiation of human neuroblastoma cells.
Cancer research 1988;48(8):2226-30.
1988: Lübbert M; Miller C W; Crawford L; Koeffler H P
p53 in chronic myelogenous leukemia. Study of mechanisms of differential expression.
The Journal of experimental medicine 1988;167(3):873-86.
1988: Koeffler H P; Heitjan D; Mertelsmann R; Kolitz J E; Schulman P; Itri L; Gunter P; Besa E
Randomized study of 13-cis retinoic acid v placebo in the myelodysplastic disorders.
Blood 1988;71(3):703-8.
1987: Tobler A; Munker R; Heitjan D; Koeffler H P
In vitro interaction of recombinant tumor necrosis factor alpha and all-trans-retinoic acid with normal and leukemic hematopoietic cells.
Blood 1987;70(6):1940-6.
1987: Munker R; DiPersio J; Koeffler H P
Tumor necrosis factor: receptors on hematopoietic cells.
Blood 1987;70(6):1730-4.
1987: Masuda H; Miller C; Koeffler H P; Battifora H; Cline M J
Rearrangement of the p53 gene in human osteogenic sarcomas.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(21):7716-9.
1987: Tobler A; Koeffler H P
Differentiation of human acute myelogenous leukemia cells: therapeutic possibilities.
Acta haematologica 1987;78 Suppl 1():127-35.

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