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Phillip Koeffler

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Ahmed Aribi; Kin T Chan; Ngan B Doan; Sigal Gery; Quoc Ho; Dhong Hyun Lee; Kunik Lee; Jonathan W Said; Gabriela B Thoennissen; Nils Thoennissen; Melvin Toh; Rocio Alvarez; H Phillip Koeffler
The triterpenoid cucurbitacin B augments the antiproliferative activity of chemotherapy in human breast cancer.
Makoto Sudo; Seiichi Mori; Jonathan W Said; Makoto Akashi; Tan Min Chin; Ngan B Doan; H Phillip Koeffler
Inhibiting proliferation of gefitinib-resistant, non-small cell lung cancer.
De-Chen Lin; Li-Zhen Liu; Paresma Patel; Jonathan W Said; Michèl Schummer; Arjun Sharma; Hongmao Sun; Patrick Tan; Craig J Thomas; Nicole Urban; Jay Vadgama; Martin Walsh; Liang Xu; Henry Yang; Dong Yin; Daniel Chan; Ling-Wen Ding; Ngan Doan; Beth Y Karlan; Jenny Lester; H Phillip Koeffler
Genomic and functional characterizations of phosphodiesterase subtype 4D in human cancers.

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All Publications

2013: Ahmed Aribi; Kin T Chan; Ngan B Doan; Sigal Gery; Quoc Ho; Dhong Hyun Lee; Kunik Lee; Jonathan W Said; Gabriela B Thoennissen; Nils Thoennissen; Melvin Toh; Rocio Alvarez; H Phillip Koeffler
The triterpenoid cucurbitacin B augments the antiproliferative activity of chemotherapy in human breast cancer.
International journal of cancer. Journal international du cancer 2013;132(12):2730-7.
2013: Makoto Sudo; Seiichi Mori; Jonathan W Said; Makoto Akashi; Tan Min Chin; Ngan B Doan; H Phillip Koeffler
Inhibiting proliferation of gefitinib-resistant, non-small cell lung cancer.
Cancer chemotherapy and pharmacology 2013;71(5):1325-34.
2013: De-Chen Lin; Li-Zhen Liu; Paresma Patel; Jonathan W Said; Michèl Schummer; Arjun Sharma; Hongmao Sun; Patrick Tan; Craig J Thomas; Nicole Urban; Jay Vadgama; Martin Walsh; Liang Xu; Henry Yang; Dong Yin; Daniel Chan; Ling-Wen Ding; Ngan Doan; Beth Y Karlan; Jenny Lester; H Phillip Koeffler
Genomic and functional characterizations of phosphodiesterase subtype 4D in human cancers.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(15):6109-14.
2013: Takahide Hayano; Norihiko Kawamata; Wenwen Chien; Ling-Wen Ding; Manoj Garg; Geraldine Leong; Seiichi Mori; Shuo Shi; Makoto Sudo; Patrick Tan; Dong Xie; Dong Yin; H Phillip Koeffler
SOX7 is down-regulated in lung cancer.
Journal of experimental & clinical cancer research : CR 2013;32(1):17.
2013: Dhruva Kumar Mishra; May Ong; Marianna Sarkissyan; Suren Sarkissyan; Xiying Shang; Zujian Chen; David Heber; H Phillip Koeffler; Yanyuan Wu; Jaydutt V Vadgama
Vitamin D Receptor Gene Polymorphisms and Prognosis of Breast Cancer among African-American and Hispanic Women.
PloS one 2013;8(3):e57967.
2012: De-Chen Lin; Lars Rönnstrand; Carol Stocking; Takayuki Tabayashi; Tong Yin; Ulla Bergholz; Ling-Wen Ding; Sigal Gery; Saskia Gueller; Julhash U Kazi; Maya Koren-Michowitz; H Phillip Koeffler
Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3.
Blood 2012;120(16):3310-7.
2012: Manja Meggendorfer; Seishi Ogawa; Andreas Roller; Kenichi Yoshida; Tamara Alpermann; Frank Dicker; Christiane Eder; Vera Grossmann; Claudia Haferlach; Torsten Haferlach; Wolfgang Kern; H Phillip Koeffler; Alexander Kohlmann; Susanne Schnittger
SRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML).
Blood 2012;120(15):3080-8.
2012: Pierre Kyme; Kunik Lee; Wolfgang E Berdel; Adrian F Gombart; W David Hardy; H Phillip Koeffler; Utz O Krug; Carsten Müller-Tidow; Kenichi Shimada; Gabriela B Thoennissen; Nils H Thoennissen; Ching Wen Tseng; Andrea J Wolf; George Y Liu
C/EBPε mediates nicotinamide-enhanced clearance of Staphylococcus aureus in mice.
The Journal of clinical investigation 2012;122(9):3316-29.
2012: Yunguang Tong; Yun Zheng; Jin Zhou; H Phillip Koeffler; Nelson M Oyesiku; Shlomo Melmed
Genomic characterization of human and rat prolactinomas.
Endocrinology 2012;153(8):3679-91.
2012: Nils Thoennissen; Sam Abbassi; Ngan B Doan; Sigal Gery; Carsten Müller-Tidow; Shayan Nabavi-Nouis; Jonathan W Said; Tim Sauer; Gabriela B Thoennissen; H Phillip Koeffler
Transcription factor CCAAT/enhancer-binding protein alpha and critical circadian clock downstream target gene PER2 are highly deregulated in diffuse large B-cell lymphoma.
Leukemia & lymphoma 2012;53(8):1577-85.
2012: Ryoko Okamoto; Jonathan W Said; Michelle Shen; Naoki Wakimoto; Tadayuki Akagi; REMI DELANSORNE; Ngan B Doan; Quoc H Ho; H Phillip Koeffler
Inecalcitol, an analog of 1α,25(OH)(2) D(3) , induces growth arrest of androgen-dependent prostate cancer cells.
International journal of cancer. Journal international du cancer 2012;130(10):2464-73.
2012: Maya Koren-Michowitz; Arnon Nagler; Seishi Ogawa; Aiko Sato-Otsubo; Torsten Haferlach; H Phillip Koeffler
Older patients with normal karyotype acute myeloid leukemia have a higher rate of genomic changes compared to young patients as determined by SNP array analysis.
Leukemia research 2012;36(4):467-73.
2012: Shuo Shi; Jiang-Sha Zhao; Yun Zhao; Di Zhu; Yue-Zhen Deng; Yu-Xiong Feng; Xiao-Dan Ji; H Phillip Koeffler; Guo Li; Jing-Jing Li; Jun Shi; Dong Xie
RACK1 promotes non-small-cell lung cancer tumorigenicity through activating sonic hedgehog signaling pathway.
The Journal of biological chemistry 2012;287(11):7845-58.
2012: Dong Yin; Weikai Chen; Daria Gaut; Catherine B Goff; Martin A Gundersen; Fikret Kirkbir; Yoshio Kuwayama; Amanda Leiter; Antonie Meixel; Jonathan W Said; David Sawcer; P Thomas Vernier; Jack Weissberg; Hongtao Xing; Wangrong G Yang; H Phillip Koeffler
Cutaneous papilloma and squamous cell carcinoma therapy utilizing nanosecond pulsed electric fields (nsPEF).
PloS one 2012;7(8):e43891.
2011: Takayuki Ikezoe; Mayuka Isaka; H Phillip Koeffler; Shinsuke Kojima; Chie Nishioka; Asako Takeuchi; Jing Yang; Mutsuo Furihata; Akihito Yokoyama
Expression of p-JAK2 predicts clinical outcome and is a potential molecular target of acute myelogenous leukemia.
International journal of cancer. Journal international du cancer 2011;129(10):2512-21.
2011: Yunguang Tong; Jin Zhou; Jun Mizutani; Song-Guang Ren; Hidenori Fukuoka; Arthur Gutierrez-Hartmann; H Phillip Koeffler; Shlomo Melmed
CEBPD suppresses prolactin expression and prolactinoma cell proliferation.
Molecular endocrinology (Baltimore, Md.) 2011;25(11):1880-91.
2011: Seisho Takeuchi; Martin Zimmermann; Claus R Bartram; Takayuki Ikezoe; Naoki Komatsu; Masahide Matsushita; Martin Schrappe; Taku Seriu; H Phillip Koeffler
Clinical significance of aberrant DNA methylation in childhood acute lymphoblastic leukemia.
Leukemia research 2011;35(10):1345-9.
2011: Yunguang Tong; Wancai Yang; H Phillip Koeffler
Mouse models of colorectal cancer.
Chinese journal of cancer 2011;30(7):450-62.
2011: W Yang; Y-H Wu; D Yin; H Phillip Koeffler; D E Sawcer; P Thomas Vernier; Martin A Gundersen
Differential sensitivities of malignant and normal skin cells to nanosecond pulsed electric fields.
Technology in cancer research & treatment 2011;10(3):281-6.
2011: Wenwen Chien; James O'Kelly; Daning Lu; Amanda Leiter; Julia Sohn; Dong Yin; Beth Karlan; Jay Vadgama; Karen M Lyons; H Phillip Koeffler
Expression of connective tissue growth factor (CTGF/CCN2) in breast cancer cells is associated with increased migration and angiogenesis.
International journal of oncology 2011;38(6):1741-7.
2011: Duy Cihangir; Christian Hurtz; Seyedmehdi Shojaee; Leandro Cerchietti; Huimin Geng; Srividya Swaminathan; Lars Klemm; Soo-mi Kweon; Rahul Nahar; Melanie Braig; Eugene Park; Yong Kim; Wolf-Karsten Hofmann; Sebastian Herzog; Hassan Jumaa; H Phillip Koeffler; J Jessica Yu; Nora Heisterkamp; Thomas G Graeber; Hong Wu; B Hilda Ye; Ari Melnick; Markus Müschen
BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition.
Nature 2011;473(7347):384-8.
2011: Saskia Gueller; Sina Hehn; Verena Nowak; Sigal Gery; Hubert Serve; Christian Brandts; H Phillip Koeffler
Adaptor protein Lnk binds to PDGF receptor and inhibits PDGF-dependent signaling.
Experimental hematology 2011;39(5):591-600.
2011: Xiao-Dan Ji; Guo Li; Yu-Xiong Feng; Jiang-Sha Zhao; Jing-Jing Li; Zhi-Jian Sun; Shuo Shi; Yue-Zhen Deng; Jun-Feng Xu; Yin-Qiu Zhu; H Phillip Koeffler; Xiang-Jun Tong; Dong Xie
EphB3 is overexpressed in non-small-cell lung cancer and promotes tumor metastasis by enhancing cell survival and migration.
Cancer research 2011;71(3):1156-66.
2011: Jiang-Sha Zhao; Li-Yan Xu; Pei-Jing Zhang; Hong Gao; Di Ge; Dong-Xian Guan; Xiao-Dan Ji; H Phillip Koeffler; Eng-Ming Li; Jing-Jing Li; Wen-Jie Li; Chun-Lai Lu; Harmik Soukiasian; Xiao-Fan Wang; Dong Xie
Tumor initiating cells in esophageal squamous cell carcinomas express high levels of CD44.
PloS one 2011;6(6):e21419.
2010: H Phillip Koeffler
Is there a role for differentiating therapy in non-APL AML?
Best practice & research. Clinical haematology 2010;23(4):503-8.
2010: Dong Yin; Weikai Chen; James O'Kelly; Daning Lu; Michelle Ham; Ngan B Doan; Dong Xie; Charles Wang; Jay Vadgama; Jonathan W Said; Keith L Black; H Phillip Koeffler
Connective tissue growth factor associated with oncogenic activities and drug resistance in glioblastoma multiforme.
International journal of cancer. Journal international du cancer 2010;127(10):2257-67.
2010: Saskia Gueller; Helen Goodridge; Birte Niebuhr; Hongtao Xing; Maya Koren-Michowitz; Hubert Serve; David M Underhill; Christian H Brandts; H Phillip Koeffler
Adaptor protein Lnk inhibits c-Fms-mediated macrophage function.
Journal of leukocyte biology 2010;88(4):699-706.
2010: Weikai Chen; Amanda Leiter; Dong Yin; Muriel Meiring; Vernon Louw; H Phillip Koeffler
Cucurbitacin B inhibits growth, arrests the cell cycle, and potentiates antiproliferative efficacy of cisplatin in cutaneous squamous cell carcinoma cell lines.
International journal of oncology 2010;37(3):737-43.
2010: Ryoko Okamoto; Seishi Ogawa; Daniel Nowak; Norihiko Kawamata; Tadayuki Akagi; Motohiro Kato; Masashi Sanada; Tamara Weiss; Claudia Haferlach; Martin Dugas; Christian Ruckert; Torsten Haferlach; H Phillip Koeffler
Genomic profiling of adult acute lymphoblastic leukemia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lymphoblastic leukemia.
Haematologica 2010;95(9):1481-8.
2010: Henrik Lilljebjörn; Charlotte Soneson; Anna Andersson; Jesper Heldrup; Mikael Behrendtz; Norihiko Kawamata; Seishi Ogawa; H Phillip Koeffler; Felix Mitelman; Bertil Johansson; Magnus Fontes; Thoas Fioretos
The correlation pattern of acquired copy number changes in 164 ETV6/RUNX1-positive childhood acute lymphoblastic leukemias.
Human molecular genetics 2010;19(16):3150-8.
2010: Seishi Ogawa; Lee-Yung Shih; Takahiro Suzuki; Makoto Otsu; Hiromitsu Nakauchi; H Phillip Koeffler; Masashi Sanada
Deregulated intracellular signaling by mutated c-CBL in myeloid neoplasms.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(15):3825-31.
2010: Jing Yang; Takayuki Ikezoe; Chie Nishioka; Lei Ni; H Phillip Koeffler; Akihito Yokoyama
Inhibition of mTORC1 by RAD001 (everolimus) potentiates the effects of 1,25-dihydroxyvitamin D(3) to induce growth arrest and differentiation of AML cells in vitro and in vivo.
Experimental hematology 2010;38(8):666-76.
2010: Duy Cihangir; J Jessica Yu; Rahul Nahar; Srividya Swaminathan; Soo-Mi Kweon; Jose M Polo; Ester Valls; Lars Klemm; Seyedmehdi Shojaee; Leandro Cerchietti; Wolfgang Schuh; Hans-Martin Jäck; Christian Hurtz; Parham Ramezani-Rad; Sebastian Herzog; Hassan Jumaa; H Phillip Koeffler; Ignacio Moreno de Alborán; Ari M Melnick; B Hilda Ye; Markus Müschen
BCL6 is critical for the development of a diverse primary B cell repertoire.
The Journal of experimental medicine 2010;207(6):1209-21.
2010: Gabriela B Iwanski; Dhong H Lee; Shlomit En-Gal; Ngan B Doan; Brandon Castor; Marco Vogt; Melvin Toh; Carsten Bokemeyer; Jonathan W Said; Nils Thoennissen; H Phillip Koeffler
Cucurbitacin B, a novel in vivo potentiator of gemcitabine with low toxicity in the treatment of pancreatic cancer.
British journal of pharmacology 2010;160(4):998-1007.
2010: Nils Thoennissen; Utz O Krug; Dhong Hyun Tony Lee; Norihiko Kawamata; Gabriela B Iwanski; Terra Lasho; Tamara Weiss; Daniel Nowak; Maya Koren-Michowitz; Motohiro Kato; Masashi Sanada; Lee-Yung Shih; Arnon Nagler; Sophie D Raynaud; Carsten Müller-Tidow; Ruben Mesa; Torsten Haferlach; D Gary Gilliland; Ayalew Tefferi; Seishi Ogawa; H Phillip Koeffler
Prevalence and prognostic impact of allelic imbalances associated with leukemic transformation of Philadelphia chromosome-negative myeloproliferative neoplasms.
Blood 2010;115(14):2882-90.
2010: Christine S Walsh; Audra Blum; Ann Walts; Randa Alsabeh; Hang Tran; H Phillip Koeffler; Beth Y Karlan
Lynch syndrome among gynecologic oncology patients meeting Bethesda guidelines for screening.
Gynecologic oncology 2010;116(3):516-21.
2010: Daniel Nowak; Seishi Ogawa; Markus Müschen; Motohiro Kato; Norihiko Kawamata; Antonie Meixel; Verena Nowak; Han S Kim; Sharon Kang; Ronald Paquette; Mi-Sook Chang; Nils H Thoennissen; Nils H Thoenissen; Max Mossner; Wolf-Karsten Hofmann; Alexander Kohlmann; Tamara Weiss; Torsten Haferlach; Claudia Haferlach; H Phillip Koeffler
SNP array analysis of tyrosine kinase inhibitor-resistant chronic myeloid leukemia identifies heterogeneous secondary genomic alterations.
Blood 2010;115(5):1049-53.
2010: Nils Thoennissen; James O'Kelly; D Lu; G B Iwanski; D T La; Sam Abbassi; A Leiter; Beth Y Karlan; Rajendra Mehta; H Phillip Koeffler
Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway.
Oncogene 2010;29(2):285-96.
2010: Ido Wolf; Y Laitman; Tami Rubinek; L Abramovitz; I Novikov; R Beeri; M Kuro-O; H Phillip Koeffler; Raphael Catane; L S Freedman; E Levy-Lahad; Beth Y Karlan; Eitan Friedman; Bella Kaufman
Functional variant of KLOTHO: a breast cancer risk modifier among BRCA1 mutation carriers of Ashkenazi origin.
Oncogene 2010;29(1):26-33.
2010: Tadayuki Akagi; Nils H Thoennissen; Ann George; Gay Crooks; Jee Hoon Song; Ryoko Okamoto; Daniel Nowak; Adrian F Gombart; H Phillip Koeffler
In vivo deficiency of both C/EBPβ and C/EBPε results in highly defective myeloid differentiation and lack of cytokine response.
PloS one 2010;5(11):e15419.
2010: Dhruva Kumar Mishra; Zujian Chen; Yanyuan Wu; Marianna Sarkissyan; H Phillip Koeffler; Jaydutt V Vadgama
Global methylation pattern of genes in androgen-sensitive and androgen-independent prostate cancer cells.
Molecular cancer therapeutics 2010;9(1):33-45.
2009: Sigal Gery; H Phillip Koeffler
Per2 is a C/EBP target gene implicated in myeloid leukemia.
Integrative cancer therapies 2009;8(4):317-20.
2009: Takayuki Ikezoe; Tamotsu Takeuchi; Jing Yang; Yoshihiro Adachi; Chie Nishioka; Mutsuo Furihata; H Phillip Koeffler; Akihito Yokoyama
Analysis of Aurora B kinase in non-Hodgkin lymphoma.
Laboratory investigation; a journal of technical methods and pathology 2009;89(12):1364-73.
2009: Tadayuki Akagi; Tetsuo Ito; Motohiro Kato; Zhe Jin; Yulan Cheng; Takatsugu Kan; Go Yamamoto; Alexandru Olaru; Norihiko Kawamata; Jessica Boult; Harmik J Soukiasian; Carl W Miller; Seishi Ogawa; Meltzer Stephen J.; H Phillip Koeffler
Chromosomal abnormalities and novel disease-related regions in progression from Barrett's esophagus to esophageal adenocarcinoma.
International journal of cancer. Journal international du cancer 2009;125(10):2349-59.
2009: Qi Cao; Sigal Gery; Azadeh Dashti; Dong Yin; Yan Zhou; Jiang Gu; H Phillip Koeffler
A role for the clock gene per1 in prostate cancer.
Cancer research 2009;69(19):7619-25.
2009: Chie Nishioka; Takayuki Ikezoe; Jing Yang; Sigal Gery; H Phillip Koeffler; Akihito Yokoyama
Inhibition of mammalian target of rapamycin signaling potentiates the effects of all-trans retinoic acid to induce growth arrest and differentiation of human acute myelogenous leukemia cells.
International journal of cancer. Journal international du cancer 2009;125(7):1710-20.
2009: Tadayuki Akagi; Lee-Yung Shih; Seishi Ogawa; Joachim Gerss; Stephen R Moore; Rhona Schreck; Norihiko Kawamata; Der-Cherng Liang; Masashi Sanada; Yasuhito Nannya; Stefan Deneberg; Vasilios Zachariadis; Ann Nordgren; Jee Hoon Song; Martin Dugas; Sören Lehmann; H Phillip Koeffler
Single nucleotide polymorphism genomic arrays analysis of t(8;21) acute myeloid leukemia cells.
Haematologica 2009;94(9):1301-6.
2009: Chie Nishioka; Takayuki Ikezoe; Jing Yang; Naoki Komatsu; H Phillip Koeffler; Akihito Yokoyama
Blockade of MEK signaling potentiates 5-Aza-2'-deoxycytidine-induced apoptosis and upregulation of p21(waf1) in acute myelogenous leukemia cells.
International journal of cancer. Journal international du cancer 2009;125(5):1168-76.
2009: Takayuki Ikezoe; Jing Yang; Chie Nishioka; Y Takezaki; Taizo Tasaka; Kazuto Togitani; H Phillip Koeffler; A Yokoyama
A novel treatment strategy targeting polo-like kinase 1 in hematological malignancies.
Leukemia 2009;23(9):1564-76.
2009: Masashi Sanada; Takahiro Suzuki; Lee-Yung Shih; Makoto Otsu; Motohiro Kato; Satoshi Yamazaki; Azusa Tamura; Hiroaki Honda; Mamiko Sakata-Yanagimoto; Keiki Kumano; Hideaki Oda; Tetsuya Yamagata; Junko Takita; Noriko Gotoh; Kumi Nakazaki; Norihiko Kawamata; Masafumi Onodera; Masaharu Nobuyoshi; Yasuhide Hayashi; Hiroshi Harada; Mineo Kurokawa; Shigeru Chiba; Hiraku Mori; Keiya Ozawa; Mitsuhiro Omine; Hisamaru Hirai; Hiromitsu Nakauchi; H Phillip Koeffler; Seishi Ogawa
Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.
Nature 2009;460(7257):904-8.
2009: Chuanbing Zang; Hongyu Liu; Janina Bertz; Kurt Possinger; H Phillip Koeffler; Elena Elstner; Jan Eucker
Induction of endoplasmic reticulum stress response by TZD18, a novel dual ligand for peroxisome proliferator-activated receptor alpha/gamma, in human breast cancer cells.
Molecular cancer therapeutics 2009;8(8):2296-307.
2009: Norihiko Kawamata; Seishi Ogawa; Saskia Gueller; Samuel Ross; Thien Huynh; John Chen; Andrew Chang; Shayan Nabavi-Nouis; Nairi Megrabian; Reiner Siebert; Jose A Martinez-Climent; H Phillip Koeffler
Identified hidden genomic changes in mantle cell lymphoma using high-resolution single nucleotide polymorphism genomic array.
Experimental hematology 2009;37(8):937-46.
2009: Nils Thoennissen; Gabriela B Iwanski; Ngan B Doan; Ryoko Okamoto; Patricia Lin; Sam Abbassi; Jee Hoon Song; Dong Yin; Melvin Toh; WeiDong Xie; Jonathan W Said; H Phillip Koeffler
Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells.
Cancer research 2009;69(14):5876-84.
2009: Tadayuki Akagi; Dong Yin; Norihiko Kawamata; Claus R Bartram; Wolf-K Hofmann; Jee Hoon Song; Carl W Miller; Monique L den Boer; H Phillip Koeffler
Functional analysis of a novel DNA polymorphism of a tandem repeated sequence in the asparagine synthetase gene in acute lymphoblastic leukemia cells.
Leukemia research 2009;33(7):991-6.
2009: Norihiko Kawamata; Seishi Ogawa; Karl Seeger; Renate Kirschner-Schwabe; Thien Huynh; John Chen; Nairi Megrabian; Jochen Harbott; Martin Zimmermann; Günter Henze; Martin Schrappe; Claus R Bartram; H Phillip Koeffler
Molecular allelokaryotyping of relapsed pediatric acute lymphoblastic leukemia.
International journal of oncology 2009;34(6):1603-12.
2009: Sigal Gery; Qi Cao; Saskia Gueller; Hongtao Xing; Ayalew Tefferi; H Phillip Koeffler
Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F.
Journal of leukocyte biology 2009;85(6):957-65.
2009: Dong Yin; Seishi Ogawa; Norihiko Kawamata; Patrizia Tunici; Gaetano Finocchiaro; Marica Eoli; Christian Ruckert; Thien Huynh; Gentao Liu; Motohiro Kato; Masashi Sanada; Anna Jauch; Martin Dugas; Keith L Black; H Phillip Koeffler
High-resolution genomic copy number profiling of glioblastoma multiforme by single nucleotide polymorphism DNA microarray.
Molecular cancer research : MCR 2009;7(5):665-77.
2009: Sigal Gery; Saskia Gueller; Verena Nowak; Julia Sohn; Wolf-Karsten Hofmann; H Phillip Koeffler
Expression of the adaptor protein Lnk in leukemia cells.
Experimental hematology 2009;37(5):585-592.e2.
2009: Daniel Nowak; Daphne Stewart; H Phillip Koeffler
Differentiation therapy of leukemia: 3 decades of development.
Blood 2009;113(16):3655-65.
2009: Daniel Nowak; Emilie Le Toriellec; Marc-Henri Stern; Norihiko Kawamata; Tadayuki Akagi; Martin J Dyer; Wolf-Karsten Hofmann; Seishi Ogawa; H Phillip Koeffler
Molecular allelokaryotyping of T-cell prolymphocytic leukemia cells with high density single nucleotide polymorphism arrays identifies novel common genomic lesions and acquired uniparental disomy.
Haematologica 2009;94(4):518-27.
2009: Norihiko Kawamata; Ling Zhang; Seishi Ogawa; Yasuhito Nannya; Azadeh Dashti; Daning Lu; Stephen Lim; Rhona Schreck; H Phillip Koeffler
Double minute chromosomes containing MYB gene and NUP214-ABL1 fusion gene in T-cell leukemia detected by single nucleotide polymorphism DNA microarray and fluorescence in situ hybridization.
Leukemia research 2009;33(4):569-71.
2009: Tadayuki Akagi; Lee-Yung Shih; Motohiro Kato; Norihiko Kawamata; Go Yamamoto; Masashi Sanada; Ryoko Okamoto; Carl W Miller; Der-Cherng Liang; Seishi Ogawa; H Phillip Koeffler
Hidden abnormalities and novel classification of t(15;17) acute promyelocytic leukemia (APL) based on genomic alterations.
Blood 2009;113(8):1741-8.
2009: Adrian F Gombart; Ishir Bhan; Niels Borregaard; Hector Tamez; Carlos A Camargo; H Phillip Koeffler; Ravi Thadhani
Low plasma level of cathelicidin antimicrobial peptide (hCAP18) predicts increased infectious disease mortality in patients undergoing hemodialysis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2009;48(4):418-24.
2009: Tadayuki Akagi; Seishi Ogawa; Martin Dugas; Norihiko Kawamata; Go Yamamoto; Yasuhito Nannya; Masashi Sanada; Carl W Miller; Amanda Yung; Susanne Schnittger; Torsten Haferlach; Claudia Haferlach; H Phillip Koeffler
Frequent genomic abnormalities in acute myeloid leukemia/myelodysplastic syndrome with normal karyotype.
Haematologica 2009;94(2):213-23.
2009: Adrian F Gombart; Tsuyako Saito; H Phillip Koeffler
Exaptation of an ancient Alu short interspersed element provides a highly conserved vitamin D-mediated innate immune response in humans and primates.
BMC genomics 2009;10():321.
2008: Christine S Walsh; Seishi Ogawa; Daniel R Scoles; Carl W Miller; Norihiko Kawamata; Steven A Narod; H Phillip Koeffler; Beth Y Karlan
Genome-wide loss of heterozygosity and uniparental disomy in BRCA1/2-associated ovarian carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(23):7645-51.
2008: Aye Aye Thant; Yanyuan Wu; Jane Lee; Dhruva Kumar Mishra; Heather Garcia; H Phillip Koeffler; Jaydutt V Vadgama
Role of caspases in 5-FU and selenium-induced growth inhibition of colorectal cancer cells.
Anticancer research 2008;28(6A):3579-92.
2008: Talin Haritunians; Saskia Gueller; James O'Kelly; Robert Ilaria; H Phillip Koeffler
Novel acyl sulfonamide LY573636-sodium: effect on hematopoietic malignant cells.
Oncology reports 2008;20(5):1237-42.
2008: Tsuyako Saito; Ryoko Okamoto; Talin Haritunians; James O'Kelly; Milan Uskokovic; Hubert Maehr; Stanislaw Marczak; Pawel Jankowski; Riem Badr; H Phillip Koeffler
Novel Gemini vitamin D(3) analogs have potent antitumor activity.
The Journal of steroid biochemistry and molecular biology 2008;112(1-3):151-6.
2008: Norihiko Kawamata; Seishi Ogawa; Go Yamamoto; Soren Lehmann; Ross Levine; Yana Pikman; Yasuhito Nannya; Masashi Sanada; Carl W Miller; D Gary Gilliland; H Phillip Koeffler
Genetic profiling of myeloproliferative disorders by single-nucleotide polymorphism oligonucleotide microarray.
Experimental hematology 2008;36(11):1471-9.
2008: Saskia Gueller; Sigal Gery; Verena Nowak; Liqin Liu; Hubert Serve; H Phillip Koeffler
Adaptor protein Lnk associates with Tyr(568) in c-Kit.
The Biochemical journal 2008;415(2):241-5.
2008: Norihiko Kawamata; Azadeh Dashti; Daning Lu; Becky Miller; H Phillip Koeffler; Rhona Schreck; Stephen R Moore; Seishi Ogawa
Chronic phase of ETV6-ABL1 positive CML responds to imatinib.
Genes, chromosomes & cancer 2008;47(10):919-21.
2008: Dong Yin; Naoki Wakimoto; Hongtao Xing; Daning Lu; Thien Huynh; Xiao Wang; Keith L Black; H Phillip Koeffler
Cucurbitacin B markedly inhibits growth and rapidly affects the cytoskeleton in glioblastoma multiforme.
International journal of cancer. Journal international du cancer 2008;123(6):1364-75.
2008: Naoki Wakimoto; Ido Wolf; Dong Yin; James O'Kelly; Tadayuki Akagi; Lilach Abramovitz; Keith L Black; Hsin-Hsiung Tai; H Phillip Koeffler
Nonsteroidal anti-inflammatory drugs suppress glioma via 15-hydroxyprostaglandin dehydrogenase.
Cancer research 2008;68(17):6978-86.
2008: Naoki Wakimoto; Dong Yin; James O'Kelly; Talin Haritunians; Beth Y Karlan; Jonathan Said; Hongtao Xing; H Phillip Koeffler
Cucurbitacin B has a potent antiproliferative effect on breast cancer cells in vitro and in vivo.
Cancer science 2008;99(9):1793-7.
2008: Talin Haritunians; Saskia Gueller; Ling Zhang; Riem Badr; Dong Yin; Hongtao Xing; Ming-Chiu Fung; H Phillip Koeffler
Cucurbitacin B induces differentiation, cell cycle arrest, and actin cytoskeletal alterations in myeloid leukemia cells.
Leukemia research 2008;32(9):1366-73.
2008: Norihiko Kawamata; Seishi Ogawa; Martin Zimmermann; Birte Niebuhr; Carol Stocking; Masashi Sanada; Kari Hemminki; Go Yamatomo; Yasuhito Nannya; Rolf Koehler; Thomas Flohr; Carl W Miller; Jochen Harbott; Wolf-Dieter Ludwig; Martin Stanulla; Martin Schrappe; Claus R Bartram; H Phillip Koeffler
Cloning of genes involved in chromosomal translocations by high-resolution single nucleotide polymorphism genomic microarray.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(33):11921-6.
2008: Michael Lübbert; Carsten Müller-Tidow; Wolf-Karsten Hofmann; H Phillip Koeffler
Advances in the treatment of acute myeloid leukemia: from chromosomal aberrations to biologically targeted therapy.
Journal of cellular biochemistry 2008;104(6):2059-70.
2008: James O'Kelly; Alice Chung; Nathan Lemp; Katya Chumakova; Dong Yin; He-Jing Wang; Jonathan Said; Dorina Gui; Carl W Miller; Beth Y Karlan; H Phillip Koeffler
Functional domains of CCN1 (Cyr61) regulate breast cancer progression.
International journal of oncology 2008;33(1):59-67.
2008: Christine S Walsh; Seishi Ogawa; Hisae Karahashi; Daniel R Scoles; James C Pavelka; Hang Tran; Carl W Miller; Norihiko Kawamata; Charles Ginther; Judy Dering; Masashi Sanada; Yasuhito Nannya; Dennis J Slamon; H Phillip Koeffler; Beth Y Karlan
ERCC5 is a novel biomarker of ovarian cancer prognosis.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(18):2952-8.
2008: Chie Nishioka; Takayuki Ikezoe; Jing Yang; Ayako Takeshita; Ayuko Taniguchi; Naoki Komatsu; Kazuto Togitani; H Phillip Koeffler; Akihito Yokoyama
Blockade of MEK/ERK signaling enhances sunitinib-induced growth inhibition and apoptosis of leukemia cells possessing activating mutations of the FLT3 gene.
Leukemia research 2008;32(6):865-72.
2008: Chie Nishioka; Takayuki Ikezoe; Jing Yang; Atsushi Miwa; Taizo Tasaka; Yoshio Kuwayama; Kazuto Togitani; H Phillip Koeffler; Akihito Yokoyama
Ki11502, a novel multitargeted receptor tyrosine kinase inhibitor, induces growth arrest and apoptosis of human leukemia cells in vitro and in vivo.
Blood 2008;111(10):5086-92.
2008: Sören Lehmann; Seishi Ogawa; Sophie D Raynaud; Masashi Sanada; Yasuhito Nannya; Michel Ticchioni; Christian Bastard; Norihiko Kawamata; H Phillip Koeffler
Molecular allelokaryotyping of early-stage, untreated chronic lymphocytic leukemia.
Cancer 2008;112(6):1296-305.
2008: Tadayuki Akagi; Takayuki Saitoh; James O'Kelly; Shizuo Akira; Adrian F Gombart; H Phillip Koeffler
Impaired response to GM-CSF and G-CSF, and enhanced apoptosis in C/EBPbeta-deficient hematopoietic cells.
Blood 2008;111(6):2999-3004.
2008: Yan Wang; Dongping Liu; Pingping Chen; H Phillip Koeffler; Xiangjun Tong; Dong Xie
Negative feedback regulation of IFN-gamma pathway by IFN regulatory factor 2 in esophageal cancers.
Cancer research 2008;68(4):1136-43.
2008: Chie Nishioka; Takayuki Ikezoe; Jing Yang; Naoki Komatsu; Kentaro Bandobashi; Ayuko Taniguchi; Yoshio Kuwayama; Kazuto Togitani; H Phillip Koeffler; Hirokuni Taguchi
Histone deacetylase inhibitors induce growth arrest and apoptosis of HTLV-1-infected T-cells via blockade of signaling by nuclear factor kappaB.
Leukemia research 2008;32(2):287-96.
2008: Norihiko Kawamata; Seishi Ogawa; Martin Zimmermann; Motohiro Kato; Masashi Sanada; Kari Hemminki; Go Yamatomo; Yasuhito Nannya; Rolf Koehler; Thomas Flohr; Carl W Miller; Jochen Harbott; Wolf-Dieter Ludwig; Martin Stanulla; Martin Schrappe; Claus R Bartram; H Phillip Koeffler
Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide polymorphism oligonucleotide genomic microarray.
Blood 2008;111(2):776-84.
2008: Moray J Campbell; Carsten Carlberg; H Phillip Koeffler
A Role for the PPARgamma in Cancer Therapy.
PPAR research 2008;2008():314974.
2007: Yue-Zhen Deng; Ping-Ping Chen; Yan Wang; Dong Yin; H Phillip Koeffler; Baojie Li; Xiang-Jun Tong; Dong Xie
Connective tissue growth factor is overexpressed in esophageal squamous cell carcinoma and promotes tumorigenicity through beta-catenin-T-cell factor/Lef signaling.
The Journal of biological chemistry 2007;282(50):36571-81.
2007: Sigal Gery; Renu K Virk; K Chumakov; A Yu; H Phillip Koeffler
The clock gene Per2 links the circadian system to the estrogen receptor.
Oncogene 2007;26(57):7916-20.
2007: Akio Mori; Julian C Desmond; Naoki Komatsu; James O'Kelly; Carl W Miller; Ronald Legaspi; Alberto M Marchevsky; Robert J McKenna; H Phillip Koeffler
CYR61: a new measure of lung cancer outcome.
Cancer investigation 2007;25(8):738-41.
2007: Dong Yin; Hiroshi Kawabata; Oxana Tcherniamtchouk; Thien Huynh; Keith L Black; H Phillip Koeffler
Glioblastoma multiforme cells: expression of erythropoietin receptor and response to erythropoietin.
International journal of oncology 2007;31(5):1193-8.
2007: Sigal Gery; Saskia Gueller; Katya Chumakova; Norihiko Kawamata; Liqin Liu; H Phillip Koeffler
Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders.
Blood 2007;110(9):3360-4.
2007: Norihiko Kawamata; John Chen; H Phillip Koeffler
Suberoylanilide hydroxamic acid (SAHA; vorinostat) suppresses translation of cyclin D1 in mantle cell lymphoma cells.
Blood 2007;110(7):2667-73.
2007: Ido Wolf; Shikha Bose; Julian C Desmond; Bryan T Lin; Elizabeth A Williamson; Beth Y Karlan; H Phillip Koeffler
Unmasking of epigenetically silenced genes reveals DNA promoter methylation and reduced expression of PTCH in breast cancer.
Breast cancer research and treatment 2007;105(2):139-55.
2007: Jing Yang; Takayuki Ikezoe; Chie Nishioka; Taizo Tasaka; Ayuko Taniguchi; Yoshio Kuwayama; Naoki Komatsu; Kentaro Bandobashi; Kazuto Togitani; H Phillip Koeffler; Hirokuni Taguchi; Akihito Yokoyama
AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo.
Blood 2007;110(6):2034-40.
2007: Yang Yang; Takayuki Ikezoe; Zhixing Zheng; Hirokuni Taguchi; H Phillip Koeffler; Wei-Guo Zhu
Saw Palmetto induces growth arrest and apoptosis of androgen-dependent prostate cancer LNCaP cells via inactivation of STAT 3 and androgen receptor signaling.
International journal of oncology 2007;31(3):593-600.
2007: S Lehmann; James O'Kelly; S Raynaud; S E Funk; E H Sage; H Phillip Koeffler
Common deleted genes in the 5q- syndrome: thrombocytopenia and reduced erythroid colony formation in SPARC null mice.
Leukemia 2007;21(9):1931-6.
2007: Edward B Garon; David Sawcer; P Thomas Vernier; Tao Tang; Yinghua Sun; Laura Marcu; Martin A Gundersen; H Phillip Koeffler
In vitro and in vivo evaluation and a case report of intense nanosecond pulsed electric field as a local therapy for human malignancies.
International journal of cancer. Journal international du cancer 2007;121(3):675-82.
2007: Takashi Kumagai; Naoki Wakimoto; Dong Yin; Sigal Gery; Norihiko Kawamata; Noriyuki Takai; Naoki Komatsu; Alexey Chumakov; Yasufumi Imai; H Phillip Koeffler
Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cells.
International journal of cancer. Journal international du cancer 2007;121(3):656-65.
2007: Jingjing Wang; William H Yong; Yinghua Sun; P Thomas Vernier; H Phillip Koeffler; Martin A Gundersen; Laura Marcu
Receptor-targeted quantum dots: fluorescent probes for brain tumor diagnosis.
Journal of biomedical optics 2007;12(4):044021.
2007: Go Yamamoto; Yasuhito Nannya; Motohiro Kato; Masashi Sanada; Ross Levine; Norihiko Kawamata; Akira Hangaishi; Mineo Kurokawa; Shigeru Chiba; D Gary Gilliland; H Phillip Koeffler; Seishi Ogawa
Highly sensitive method for genomewide detection of allelic composition in nonpaired, primary tumor specimens by use of affymetrix single-nucleotide-polymorphism genotyping microarrays.
American journal of human genetics 2007;81(1):114-26.
2007: Takayuki Ikezoe; Jing Yang; Chie Nishioka; Taizo Tasaka; Ayuko Taniguchi; Yoshio Kuwayama; Naoki Komatsu; Kentaro Bandobashi; Kazuto Togitani; H Phillip Koeffler; Hirokuni Taguchi
A novel treatment strategy targeting Aurora kinases in acute myelogenous leukemia.
Molecular cancer therapeutics 2007;6(6):1851-7.
2007: Ido Wolf; James O'Kelly; Naoki Wakimoto; Anh Nguyen; Franck Amblard; Beth Y Karlan; Jack L Arbiser; H Phillip Koeffler
Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest.
International journal of oncology 2007;30(6):1529-37.
2007: Chie Nishioka; Takayuki Ikezoe; A Takeshita; Jing Yang; Taizo Tasaka; Y Yang; Yoshio Kuwayama; N Komatsu; Kazuto Togitani; H Phillip Koeffler; Hirokuni Taguchi
ZD6474 induces growth arrest and apoptosis of human leukemia cells, which is enhanced by concomitant use of a novel MEK inhibitor, AZD6244.
Leukemia 2007;21(6):1308-10.
2007: Adrian F Gombart; Jeffrey Grewal; H Phillip Koeffler
ATF4 differentially regulates transcriptional activation of myeloid-specific genes by C/EBPepsilon and C/EBPalpha.
Journal of leukocyte biology 2007;81(6):1535-47.
2007: Alexey Chumakov; Agnes Silla; Elizabeth A Williamson; H Phillip Koeffler
Modulation of DNA binding properties of CCAAT/enhancer binding protein epsilon by heterodimer formation and interactions with NFkappaB pathway.
Blood 2007;109(10):4209-19.
2007: Miyuki Tanaka; Adrian F Gombart; H Phillip Koeffler; Masaaki Shiohara
Expression of bactericidal/permeability-increasing protein requires C/EBP epsilon.
International journal of hematology 2007;85(4):304-11.
2007: Chie Nishioka; Takayuki Ikezoe; Jing Yang; H Phillip Koeffler; Hirokuni Taguchi
Fludarabine induces apoptosis of human T-cell leukemia virus type 1-infected T cells via inhibition of the nuclear factor-kappaB signal pathway.
Leukemia 2007;21(5):1044-9.
2007: Julian C Desmond; S Raynaud; E Tung; Wolf-Karsten Hofmann; T Haferlach; H Phillip Koeffler
Discovery of epigenetically silenced genes in acute myeloid leukemias.
Leukemia 2007;21(5):1026-34.
2007: Edward B Garon; Laura Marcu; Quang Luong; Oxana Tcherniantchouk; Gay M Crooks; H Phillip Koeffler
Quantum dot labeling and tracking of human leukemic, bone marrow and cord blood cells.
Leukemia research 2007;31(5):643-51.
2007: Takayuki Ikezoe; Chie Nishioka; Kentaro Bandobashi; Yang Yang; Yoshio Kuwayama; Yoshihiro Adachi; Tamotsu Takeuchi; H Phillip Koeffler; Hirokuni Taguchi
Longitudinal inhibition of PI3K/Akt/mTOR signaling by LY294002 and rapamycin induces growth arrest of adult T-cell leukemia cells.
Leukemia research 2007;31(5):673-82.
2007: Sigal Gery; Dorothy J Park; Peter T Vuong; Renu K Virk; Claudia I Muller; Wolf-Karsten Hofmann; H Phillip Koeffler
RTP801 is a novel retinoic acid-responsive gene associated with myeloid differentiation.
Experimental hematology 2007;35(4):572-8.
2007: Dong-Ping Liu; Yan Wang; H Phillip Koeffler; Dong Xie
Ephrin-A1 is a negative regulator in glioma through down-regulation of EphA2 and FAK.
International journal of oncology 2007;30(4):865-71.
2007: Takashi Kumagai; Claudia I Müller; Julian C Desmond; Yasufumi Imai; David Heber; H Phillip Koeffler
Scutellaria baicalensis, a herbal medicine: anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines.
Leukemia research 2007;31(4):523-30.
2007: Yan Wang; Dong-Ping Liu; Ping-Ping Chen; H Phillip Koeffler; Xiang-Jun Tong; Dong Xie
Involvement of IFN regulatory factor (IRF)-1 and IRF-2 in the formation and progression of human esophageal cancers.
Cancer research 2007;67(6):2535-43.
2007: Dong-Ping Liu; Robert Z Qi; Yan Wang; Ping-Ping Chen; H Phillip Koeffler; Dong Xie
Discovery of stage-related proteins in esophageal squamous cell carcinoma using proteomic analysis.
Proteomics. Clinical applications 2007;1(3):312-20.
2007: Adrian F Gombart; James O'Kelly; Tsuyako Saito; H Phillip Koeffler
Regulation of the CAMP gene by 1,25(OH)2D3 in various tissues.
The Journal of steroid biochemistry and molecular biology 2007;103(3-5):552-7.
2007: Sigal Gery; Naoki Komatsu; Norihiko Kawamata; Carl W Miller; Julian Desmond; Renu K Virk; Alberto M Marchevsky; Robert McKenna; Hirokuni Taguchi; H Phillip Koeffler
Epigenetic silencing of the candidate tumor suppressor gene Per1 in non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(5):1399-404.
2007: Ido Wolf; Shikha Bose; Elizabeth A Williamson; Carl W Miller; Beth Y Karlan; H Phillip Koeffler
FOXA1: Growth inhibitor and a favorable prognostic factor in human breast cancer.
International journal of cancer. Journal international du cancer 2007;120(5):1013-22.
2007: Christine S Walsh; Carl W Miller; Beth Y Karlan; H Phillip Koeffler
Association between a functional single nucleotide polymorphism in the MDM2 gene and sporadic endometrial cancer risk.
Gynecologic oncology 2007;104(3):660-4.
2007: Dong Yin; John M Ong; Jinwei Hu; Julian C Desmond; Norihiko Kawamata; Bindu M Konda; Keith L Black; H Phillip Koeffler
Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor: effects on gene expression and growth of glioma cells in vitro and in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(3):1045-52.
2007: Sigal Gery; H Phillip Koeffler
Transcription factors in hematopoietic malignancies.
Current opinion in genetics & development 2007;17(1):78-83.
2007: T Haritunians; A Mori; James O'Kelly; Quang T Luong; Francis Giles; H Phillip Koeffler
Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphoma.
Leukemia 2007;21(2):333-9.
2007: Ping-Ping Chen; Wen-Jie Li; Yan Wang; Song Zhao; De-Yun Li; Li-Yun Feng; Xiang-Lin Shi; H Phillip Koeffler; Xiang-Jun Tong; Dong Xie
Expression of Cyr61, CTGF, and WISP-1 correlates with clinical features of lung cancer.
PloS one 2007;2(6):e534.
2007: Dong Yin; Naoki Komatsu; Carl W Miller; Alexey Chumakov; Alberto Marschesky; Robert McKenna; Keith L Black; H Phillip Koeffler
KLF6: mutational analysis and effect on cancer cell proliferation.
International journal of oncology 2007;30(1):65-72.
2007: Claudia I Müller; Carl W Miller; Wolf-Karsten Hofmann; Mitchell E Gross; Christine S Walsh; Norihiko Kawamata; Quang T Luong; H Phillip Koeffler
Rare mutations of the PIK3CA gene in malignancies of the hematopoietic system as well as endometrium, ovary, prostate and osteosarcomas, and discovery of a PIK3CA pseudogene.
Leukemia research 2007;31(1):27-32.
2006: Yang Yang; Takayuki Ikezoe; Chie Nishioka; Kentaro Bandobashi; Tamotsu Takeuchi; Yoshihiro Adachi; Makoto Kobayashi; Seisho Takeuchi; H Phillip Koeffler; Hirokuni Taguchi
NFV, an HIV-1 protease inhibitor, induces growth arrest, reduced Akt signalling, apoptosis and docetaxel sensitisation in NSCLC cell lines.
British journal of cancer 2006;95(12):1653-62.
2006: Yang Yang; Takayuki Ikezoe; Chie Nishioka; Takahiro Taguchi; Wei-Guo Zhu; H Phillip Koeffler; Hirokuni Taguchi
ZD6474 induces growth arrest and apoptosis of GIST-T1 cells, which is enhanced by concomitant use of sunitinib.
Cancer science 2006;97(12):1404-9.
2006: Wolf-Karsten Hofmann; S Takeuchi; N Takeuchi; Eckhard Thiel; Dieter Hoelzer; H Phillip Koeffler
Comparative analysis of hypermethylation of cell cycle control and DNA-mismatch repair genes in low-density and CD34+ bone marrow cells from patients with myelodysplastic syndrome.
Leukemia research 2006;30(11):1347-53.
2006: Chuanbing Zang; Hongyu Liu; Marlies Waechter; Jan Eucker; Janina Bertz; Kurt Possinger; H Phillip Koeffler; Elena Elstner
Dual PPARalpha/gamma ligand TZD18 either alone or in combination with imatinib inhibits proliferation and induces apoptosis of human CML cell lines.
Cell cycle (Georgetown, Tex.) 2006;5(19):2237-43.
2006: Claudia I Müller; Björn Rüter; H Phillip Koeffler; Michael Lübbert
DNA hypermethylation of myeloid cells, a novel therapeutic target in MDS and AML.
Current pharmaceutical biotechnology 2006;7(5):315-21.
2006: Takayuki Ikezoe; Chie Nishioka; Taizo Tasaka; Yang Yang; Naoki Komatsu; Kazuto Togitani; H Phillip Koeffler; Hirokuni Taguchi
The antitumor effects of sunitinib (formerly SU11248) against a variety of human hematologic malignancies: enhancement of growth inhibition via inhibition of mammalian target of rapamycin signaling.
Molecular cancer therapeutics 2006;5(10):2522-30.
2006: Quang T Luong; James O'Kelly; Glenn D Braunstein; Jerome M Hershman; H Phillip Koeffler
Antitumor activity of suberoylanilide hydroxamic acid against thyroid cancer cell lines in vitro and in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(18):5570-7.
2006: Takayuki Ikezoe; Yang Yang; Chie Nishioka; Kentaro Bandobashi; Hajime Nakatani; Takahiro Taguchi; H Phillip Koeffler; Hirokuni Taguchi
Effect of SU11248 on gastrointestinal stromal tumor-T1 cells: enhancement of growth inhibition via inhibition of 3-kinase/Akt/mammalian target of rapamycin signaling.
Cancer science 2006;97(9):945-51.
2006: Ido Wolf; James O'Kelly; Tami Rubinek; Min Tong; Anh Nguyen; Bryan T Lin; Hsin-Hsiung Tai; Beth Y Karlan; H Phillip Koeffler
15-hydroxyprostaglandin dehydrogenase is a tumor suppressor of human breast cancer.
Cancer research 2006;66(15):7818-23.
2006: Wenwen Chien; Dong Yin; Dorina Gui; Akio Mori; Jonathan M Frank; Jonathan Said; Donato Kusuanco; Alberto M Marchevsky; Robert McKenna; H Phillip Koeffler
Suppression of cell proliferation and signaling transduction by connective tissue growth factor in non-small cell lung cancer cells.
Molecular cancer research : MCR 2006;4(8):591-8.
2006: Takayuki Ikezoe; Yang Yang; Takayuki Saitoh; David Heber; Robert McKenna; Hirokuni Taguchi; H Phillip Koeffler
PC-SPES down-regulates COX-2 via inhibition of NF-kappaB and C/EBPbeta in non-small cell lung cancer cells.
International journal of oncology 2006;29(2):453-61.
2006: James O'Kelly; Milan Uskokovic; Nathan Lemp; Jaydutt Vadgama; H Phillip Koeffler
Novel Gemini-vitamin D3 analog inhibits tumor cell growth and modulates the Akt/mTOR signaling pathway.
The Journal of steroid biochemistry and molecular biology 2006;100(4-5):107-16.
2006: Takayuki Ikezoe; Kentaro Bandobashi; Yang Yang; Seisho Takeuchi; Nobuo Sekiguchi; Shuichi Sakai; H Phillip Koeffler; Hirokuni Taguchi
HIV-1 protease inhibitor ritonavir potentiates the effect of 1,25-dihydroxyvitamin D3 to induce growth arrest and differentiation of human myeloid leukemia cells via down-regulation of CYP24.
Leukemia research 2006;30(8):1005-11.
2006: Adrian F Gombart; Quang T Luong; H Phillip Koeffler
Vitamin D compounds: activity against microbes and cancer.
Anticancer research 2006;26(4A):2531-42.
2006: Claudia I Müller; Takashi Kumagai; James O'Kelly; Navindra P Seeram; David Heber; H Phillip Koeffler
Ganoderma lucidum causes apoptosis in leukemia, lymphoma and multiple myeloma cells.
Leukemia research 2006;30(7):841-8.
2006: Yang Yang; Takayuki Ikezoe; Tamotsu Takeuchi; Yoshihiro Adachi; Yuji Ohtsuki; H Phillip Koeffler; Hirokuni Taguchi
Zanthoxyli Fructus induces growth arrest and apoptosis of LNCaP human prostate cancer cells in vitro and in vivo in association with blockade of the AKT and AR signal pathways.
Oncology reports 2006;15(6):1581-90.
2006: Sigal Gery; Naoki Komatsu; Lilit Baldjyan; Andrew Yu; Danielle Koo; H Phillip Koeffler
The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells.
Molecular cell 2006;22(3):375-82.
2006: Hongyu Liu; Chuanbing Zang; Martin Fenner; Dachuan Liu; Kurt Possinger; H Phillip Koeffler; Elena Elstner
Growth inhibition and apoptosis in human Philadelphia chromosome-positive lymphoblastic leukemia cell lines by treatment with the dual PPARalpha/gamma ligand TZD18.
Blood 2006;107(9):3683-92.
2006: Dong Yin; Dong Xie; Sakura Sakajiri; Carl W Miller; H Zhu; M L Popoviciu; Jonathan W Said; Keith L Black; H Phillip Koeffler
DLK1: increased expression in gliomas and associated with oncogenic activities.
Oncogene 2006;25(13):1852-61.
2006: Akio Mori; Sören Lehmann; James O'Kelly; Takashi Kumagai; Julian C Desmond; Milena Pervan; william mcbride; Masahiro Kizaki; H Phillip Koeffler
Capsaicin, a component of red peppers, inhibits the growth of androgen-independent, p53 mutant prostate cancer cells.
Cancer research 2006;66(6):3222-9.
2006: Elizabeth A Williamson; Ido Wolf; J O'Kelly; Shikha Bose; Sakae Tanosaki; H Phillip Koeffler
BRCA1 and FOXA1 proteins coregulate the expression of the cell cycle-dependent kinase inhibitor p27(Kip1).
Oncogene 2006;25(9):1391-9.
2006: Naoki Komatsu; Norihiko Kawamata; Seisho Takeuchi; Dong Yin; Wenwen Chien; Carl W Miller; H Phillip Koeffler
SAHA, a HDAC inhibitor, has profound anti-growth activity against non-small cell lung cancer cells.
Oncology reports 2006;15(1):187-91.
2006: Yang Yang; Seisho Takeuchi; Wolf-Karsten Hofmann; Takayuki Ikezoe; Jacques J M van Dongen; Tomasz Szczepański; Claus R Bartram; Norihide Yoshino; Hirokuni Taguchi; H Phillip Koeffler
Aberrant methylation in promoter-associated CpG islands of multiple genes in acute lymphoblastic leukemia.
Leukemia research 2006;30(1):98-102.
2005: Noriyuki Takai; Anjali Jain; Norihiko Kawamata; Laura M Popoviciu; Jonathan W Said; Sadie Whittaker; Isao Miyakawa; David B Agus; H Phillip Koeffler
2C4, a monoclonal antibody against HER2, disrupts the HER kinase signaling pathway and inhibits ovarian carcinoma cell growth.
Cancer 2005;104(12):2701-8.
2005: Julian C Desmond; Hiroshi Kawabata; Carsten Mueller-Tidow; Eriko Simamura; David Heber; Kei-Ichi Hirai; H Phillip Koeffler
The synthetic furanonaphthoquinone induces growth arrest, apoptosis and differentiation in a variety of leukaemias and multiple myeloma cells.
British journal of haematology 2005;131(4):520-9.
2005: Adrian F Gombart; Utz Krug; James O'Kelly; Eun An; Vijaya Vegesna; H Phillip Koeffler
Aberrant expression of neutrophil and macrophage-related genes in a murine model for human neutrophil-specific granule deficiency.
Journal of leukocyte biology 2005;78(5):1153-65.
2005: H Phillip Koeffler; Noune Aslanian; James O'Kelly
Vitamin D(2) analog (Paricalcitol; Zemplar) for treatment of myelodysplastic syndrome.
Leukemia research 2005;29(11):1259-62.
2005: Sigal Gery; Dong Xie; Dong Yin; Hani Gabra; Carl Miller; Heming Wang; Diane Scott; William S Yi; Miriam L Popoviciu; Jonathan W Said; H Phillip Koeffler
Ovarian carcinomas: CCN genes are aberrantly expressed and CCN1 promotes proliferation of these cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(20):7243-54.
2005: Sigal Gery; Adrian F Gombart; William S Yi; Chloe Koeffler; Wolf-Karsten Hofmann; H Phillip Koeffler
Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia.
Blood 2005;106(8):2827-36.
2005: Ido Paz-Priel; Dong Hong Cai; Dehua Wang; Jeanne Kowalski; Amanda Blackford; Huaitian Liu; Caroline A Heckman; Adrian F Gombart; H Phillip Koeffler; Linda M Boxer; Alan D Friedman
CCAAT/enhancer binding protein alpha (C/EBPalpha) and C/EBPalpha myeloid oncoproteins induce bcl-2 via interaction of their basic regions with nuclear factor-kappaB p50.
Molecular cancer research : MCR 2005;3(10):585-96.
2005: Quang T Luong; H Phillip Koeffler
Vitamin D compounds in leukemia.
The Journal of steroid biochemistry and molecular biology 2005;97(1-2):195-202.
2005: Claudia I Müller; Carl W Miller; Hiroshi Kawabata; Robert J McKenna; Alberto M Marchevsky; H Phillip Koeffler
Do cancer cells selectively mutate HFE to increase their intracellular iron?
Oncology reports 2005;14(2):299-303.
2005: Sakura Sakajiri; James O'Kelly; Dong Yin; Carl W Miller; Wolf-Karsten Hofmann; Kazuo Oshimi; Lee-Yung Shih; K-H Kim; H S Sul; Charlotte H Jensen; Børge Teisner; Norihiko Kawamata; H Phillip Koeffler
Dlk1 in normal and abnormal hematopoiesis.
Leukemia 2005;19(8):1404-10.
2005: Yang Yang; Takayuki Ikezoe; Tamotsu Takeuchi; Yoshihiro Adachi; Yuji Ohtsuki; Seisho Takeuchi; H Phillip Koeffler; Hirokuni Taguchi
HIV-1 protease inhibitor induces growth arrest and apoptosis of human prostate cancer LNCaP cells in vitro and in vivo in conjunction with blockade of androgen receptor STAT3 and AKT signaling.
Cancer science 2005;96(7):425-33.
2005: Adrian F Gombart; Niels Borregaard; H Phillip Koeffler
Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(9):1067-77.
2005: Masahide Matsushita; Seisho Takeuchi; Yang Yang; Norihide Yoshino; Kunihiro Tsukasaki; Hirokuni Taguchi; H Phillip Koeffler; Hiromi Seo
Methylation of the MLH1 gene in hematological malignancies.
Oncology reports 2005;14(1):191-4.
2005: Takayuki Ikezoe; Sigal Gery; Dong Yin; James O'Kelly; Lise Binderup; Nathan Lemp; Hirokuni Taguchi; H Phillip Koeffler
CCAAT/enhancer-binding protein delta: a molecular target of 1,25-dihydroxyvitamin D3 in androgen-responsive prostate cancer LNCaP cells.
Cancer research 2005;65(11):4762-8.
2005: Elizabeth A Williamson; Ian K Williamson; Alexey Chumakov; Alan D Friedman; H Phillip Koeffler
CCAAT/enhancer binding protein epsilon: changes in function upon phosphorylation by p38 MAP kinase.
Blood 2005;105(10):3841-7.
2005: Noriyuki Takai; Norihiko Kawamata; Christine S Walsh; Sigal Gery; Julian C Desmond; Sadie Whittaker; Jonathan W Said; Laura M Popoviciu; Peter A Jones; Isao Miyakawa; H Phillip Koeffler
Discovery of epigenetically masked tumor suppressor genes in endometrial cancer.
Molecular cancer research : MCR 2005;3(5):261-9.
2005: Sigal Gery; Sakae Tanosaki; Shikha Bose; Namrata Bose; Jaydutt Vadgama; H Phillip Koeffler
Down-regulation and growth inhibitory role of C/EBPalpha in breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(9):3184-90.
2005: Letetia C Jones; Ayalew Tefferi; Peter T Vuong; Julian C Desmond; Wolf-Karsten Hofmann; H Phillip Koeffler
Detection of aberrant gene expression in CD34+ hematopoietic stem cells from patients with agnogenic myeloid metaplasia using oligonucleotide microarrays.
Stem cells (Dayton, Ohio) 2005;23(5):631-7.
2005: Norihiko Kawamata; Kei-Ji Sugimoto; Sakura Sakajiri; Kazuo Oshimi; H Phillip Koeffler
Mxi1 isoforms are expressed in hematological cell lines and normal bone marrow.
International journal of oncology 2005;26(5):1369-75.
2005: Takashi Kumagai; Ayalew Tefferi; Letetia Jones; H Phillip Koeffler
Methylation analysis of the cell cycle control genes in myelofibrosis with myeloid metaplasia.
Leukemia research 2005;29(5):511-5.
2005: Takayuki Ikezoe; Yang Yang; Kentaro Bandobashi; Tsuyako Saito; Shigeki Takemoto; Hisanori Machida; Kazuto Togitani; H Phillip Koeffler; Hirokuni Taguchi
Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-kappa B signal pathways.
Molecular cancer therapeutics 2005;4(4):578-86.
2005: Takashi Kumagai; Lee-Yung Shih; Susan V Hughes; Julian C Desmond; James O'Kelly; Martin Hewison; H Phillip Koeffler
19-Nor-1,25(OH)2D2 (a novel, noncalcemic vitamin D analogue), combined with arsenic trioxide, has potent antitumor activity against myeloid leukemia.
Cancer research 2005;65(6):2488-97.
2005: Paulette Mhawech; Ana Benz; Christelle Cerato; Vincent Greloz; Mounia Assaly; Julian C Desmond; H Phillip Koeffler; Dimitri Lodygin; Heiko Hermeking; Francois Herrmann; Juerg Schwaller
Downregulation of 14-3-3sigma in ovary, prostate and endometrial carcinomas is associated with CpG island methylation.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2005;18(3):340-8.
2005: Sigal Gery; Sakae Tanosaki; Wolf-Karsten Hofmann; Ahrin Koppel; H Phillip Koeffler
C/EBPdelta expression in a BCR-ABL-positive cell line induces growth arrest and myeloid differentiation.
Oncogene 2005;24(9):1589-97.
2005: Dong Yin; Hong Zhou; Takashi Kumagai; Gentao Liu; John M Ong; Keith L Black; H Phillip Koeffler
Proteasome inhibitor PS-341 causes cell growth arrest and apoptosis in human glioblastoma multiforme (GBM).
Oncogene 2005;24(3):344-54.
2005: Sakura Sakajiri; Takashi Kumagai; Norihiko Kawamata; Takayuki Saitoh; Jonathan W Said; H Phillip Koeffler
Histone deacetylase inhibitors profoundly decrease proliferation of human lymphoid cancer cell lines.
Experimental hematology 2005;33(1):53-61.
2005: Wolf-Karsten Hofmann; H Phillip Koeffler
Myelodysplastic syndrome.
Annual review of medicine 2005;56():1-16.
2005: Yang Yang; Seisho Takeuchi; Kunihiro Tsukasaki; Yasuaki Yamada; Tomoko Hata; Naoki Mori; Atsuki Fukushima; Hiromi Seo; H Phillip Koeffler; Hirokuni Taguchi
Methylation analysis of the adenomatous polyposis coli (APC) gene in adult T-cell leukemia/lymphoma.
Leukemia research 2005;29(1):47-51.
2005: Hiroshi Kawabata; Robert E Fleming; Dorina Gui; Seo Y Moon; Takayuki Saitoh; James O'Kelly; Yutaka Umehara; Yuji Wano; Jonathan W Said; H Phillip Koeffler
Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis.
Blood 2005;105(1):376-81.
2004: Wenwen Chien; Takashi Kumagai; Carl W Miller; Julian C Desmond; Jonathan M Frank; Jonathan W Said; H Phillip Koeffler
Cyr61 suppresses growth of human endometrial cancer cells.
The Journal of biological chemistry 2004;279(51):53087-96.
2004: Noriyuki Takai; Norihiko Kawamata; Dorina Gui; Jonathan W Said; Isao Miyakawa; H Phillip Koeffler
Human ovarian carcinoma cells: histone deacetylase inhibitors exhibit antiproliferative activity and potently induce apoptosis.
Cancer 2004;101(12):2760-70.
2004: Sigal Gery; Dorothy J Park; Peter T Vuong; Doris Y Chih; Nathan Lemp; H Phillip Koeffler
Retinoic acid regulates C/EBP homologous protein expression (CHOP), which negatively regulates myeloid target genes.
Blood 2004;104(13):3911-7.
2004: Jennifer Worch; Lara Tickenbrock; Joachim Schwäble; Björn Steffen; Thomas Cauvet; Barbara Mlody; Horst Buerger; H Phillip Koeffler; Wolfgang E Berdel; Hubert Serve; Carsten Müller-Tidow
The serine-threonine kinase MNK1 is post-translationally stabilized by PML-RARalpha and regulates differentiation of hematopoietic cells.
Oncogene 2004;23(57):9162-72.
2004: Doris Y Chih; Dorothy J Park; Mitchell Gross; Gregory E Idos; Peter T Vuong; Toshiyasu Hirama; Alexey Chumakov; Jonathan Said; H Phillip Koeffler
Protein partners of C/EBPepsilon.
Experimental hematology 2004;32(12):1173-81.
2004: Hiroshi Kawabata; Xiangjun Tong; Takafumi Kawanami; Yuji Wano; Yuko Hirose; Susumu Sugai; H Phillip Koeffler
Analyses for binding of the transferrin family of proteins to the transferrin receptor 2.
British journal of haematology 2004;127(4):464-73.
2004: Takayuki Ikezoe; Yasuko Hisatake; Tamotsu Takeuchi; Yuji Ohtsuki; Yang Yang; Jonathan W Said; Hirokuni Taguchi; H Phillip Koeffler
HIV-1 protease inhibitor, ritonavir: a potent inhibitor of CYP3A4, enhanced the anticancer effects of docetaxel in androgen-independent prostate cancer cells in vitro and in vivo.
Cancer research 2004;64(20):7426-31.
2004: Letetia C Jones; Ayalew Tefferi; Gregory E Idos; Takashi Kumagai; Wolf-Karsten Hofmann; H Phillip Koeffler
RARbeta2 is a candidate tumor suppressor gene in myelofibrosis with myeloid metaplasia.
Oncogene 2004;23(47):7846-53.
2004: Marina Konopleva; Elena Elstner; Teresa McQueen; Twee Tsao; Andrey Sudarikov; Wei Hu; Wendy D Schober; Rui-Yu Wang; David Chism; Steven M Kornblau; Anas Younes; Steven J Collins; H Phillip Koeffler; Michael Andreeff
Peroxisome proliferator-activated receptor gamma and retinoid X receptor ligands are potent inducers of differentiation and apoptosis in leukemias.
Molecular cancer therapeutics 2004;3(10):1249-62.
2004: Carsten Müller-Tidow; Ping Ji; Sven Diederichs; Jenny Potratz; Nicole Bäumer; Gabriele Köhler; Thomas Cauvet; Chunaram Choudary; Tiffany van der Meer; Wan-Yu Iris Chan; Conrad Nieduszynski; William H Colledge; Mary Carrington; H Phillip Koeffler; Anja Restle; Lisa Wiesmüller; Joëlle Sobczak-Thépot; Wolfgang E Berdel; Hubert Serve
The cyclin A1-CDK2 complex regulates DNA double-strand break repair.
Molecular and cellular biology 2004;24(20):8917-28.
2004: Seisho Takeuchi; Naoko Takeuchi; Kunihiro Tsukasaki; Yang Yang; Anthony C Fermin; Masao Tomonaga; Carl W Miller; Hiromi Seo; H Phillip Koeffler
Methylenetetrahydrofolate reductase genotype does not play a role in adult T-cell leukemia/lymphoma pathogenesis among human T-lymphotrophic virus type 1 carriers.
Leukemia research 2004;28(10):1039-41.
2004: Sven Diederichs; Nicole Bäumer; Ping Ji; Stephan K Metzelder; Gregory E Idos; Thomas Cauvet; Wenbing Wang; Maria Möller; Sarah Pierschalski; Jörg Gromoll; Mark Schrader; H Phillip Koeffler; Wolfgang E Berdel; Hubert Serve; Carsten Müller-Tidow
Identification of interaction partners and substrates of the cyclin A1-CDK2 complex.
The Journal of biological chemistry 2004;279(32):33727-41.
2004: Roberta Morosetti; Tiziana Servidei; Massimiliano Mirabella; Sergio Rutella; Annunziato Mangiola; Giulio Maira; Renato Mastrangelo; H Phillip Koeffler
The PPARgamma ligands PGJ2 and rosiglitazone show a differential ability to inhibit proliferation and to induce apoptosis and differentiation of human glioblastoma cell lines.
International journal of oncology 2004;25(2):493-502.
2004: Chise Matsushita; Yang Yang; Seisho Takeuchi; Masahide Matsushita; Jacques J M van Dongen; Tomasz Szczepanski; Claus R Bartram; Hiromi Seo; H Phillip Koeffler; Hirokuni Taguchi
Aberrant methylation in promoter-associated CpG islands of multiple genes in relapsed childhood acute lymphoblastic leukemia.
Oncology reports 2004;12(1):97-9.
2004: Takayuki Ikezoe; Sakae Tanosaki; Utz Krug; Bingrong Liu; Pinchas Cohen; Hirokuni Taguchi; H Phillip Koeffler
Insulin-like growth factor binding protein-3 antagonizes the effects of retinoids in myeloid leukemia cells.
Blood 2004;104(1):237-42.
2004: Xiangjun Tong; James O'Kelly; Dong Xie; Akio Mori; Nathan Lemp; Robert McKenna; Carl W Miller; H Phillip Koeffler
Cyr61 suppresses the growth of non-small-cell lung cancer cells via the beta-catenin-c-myc-p53 pathway.
Oncogene 2004;23(28):4847-55.
2004: Seisho Takeuchi; Sven de Vos; Naoko Takeuchi; Anthony C Fermin; Thomas M Grogan; Hiromi Seo; Jonathan W Said; H Phillip Koeffler
Allelic loss during progression of follicular lymphoma.
Leukemia research 2004;28(6):567-9.
2004: Takayuki Ikezoe; Y Yang; Hirokuni Taguchi; H Phillip Koeffler
JNK interacting protein 1 (JIP-1) protects LNCaP prostate cancer cells from growth arrest and apoptosis mediated by 12-0-tetradecanoylphorbol-13-acetate (TPA).
British journal of cancer 2004;90(10):2017-24.
2004: Kunihiro Tsukasaki; Sakae Tanosaki; Sven DeVos; Wolf-Karsten Hofmann; William Wachsman; Adrian F Gombart; Johannes Krebs; Anna Jauch; Claus R Bartram; Kazuhiro Nagai; Masao Tomonaga; Jonathan W Said; H Phillip Koeffler
Identifying progression-associated genes in adult T-cell leukemia/lymphoma by using oligonucleotide microarrays.
International journal of cancer. Journal international du cancer 2004;109(6):875-81.
2004: Alexey Chumakov; Tetsuya Kubota; Steffen Walter; H Phillip Koeffler
Identification of murine and human XCP1 genes as C/EBP-epsilon-dependent members of FIZZ/Resistin gene family.
Oncogene 2004;23(19):3414-25.
2004: Takayuki Ikezoe; Tsuyako Saito; Kentaro Bandobashi; Yang Yang; H Phillip Koeffler; Hirokuni Taguchi
HIV-1 protease inhibitor induces growth arrest and apoptosis of human multiple myeloma cells via inactivation of signal transducer and activator of transcription 3 and extracellular signal-regulated kinase 1/2.
Molecular cancer therapeutics 2004;3(4):473-9.
2004: Carsten Müller-Tidow; Björn Steffen; Thomas Cauvet; Lara Tickenbrock; Ping Ji; Sven Diederichs; Bülent Sargin; Gabriele Köhler; Matthias Stelljes; Elena Puccetti; Martin Ruthardt; Sven deVos; Scott W Hiebert; H Phillip Koeffler; Wolfgang E Berdel; Hubert Serve
Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.
Molecular and cellular biology 2004;24(7):2890-904.
2004: Dong Yin; Dong Xie; Sven De Vos; Gentao Liu; Carl W Miller; Keith L Black; H Phillip Koeffler
Imprinting status of DLK1 gene in brain tumors and lymphomas.
International journal of oncology 2004;24(4):1011-5.
2004: Dong Xie; Dong Yin; He-Jing Wang; Gen-Tao Liu; Robert Elashoff; Keith Black; H Phillip Koeffler
Levels of expression of CYR61 and CTGF are prognostic for tumor progression and survival of individuals with gliomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(6):2072-81.
2004: Dong Xie; Dong Yin; Xiangjun Tong; James O'Kelly; Akio Mori; Carl Miller; Keith Black; Dorina Gui; Jonathan W Said; H Phillip Koeffler
Cyr61 is overexpressed in gliomas and involved in integrin-linked kinase-mediated Akt and beta-catenin-TCF/Lef signaling pathways.
Cancer research 2004;64(6):1987-96.
2004: Takayuki Ikezoe; Yang Yang; Tsuyako Saito; H Phillip Koeffler; Hirokuni Taguchi
Proteasome inhibitor PS-341 down-regulates prostate-specific antigen (PSA) and induces growth arrest and apoptosis of androgen-dependent human prostate cancer LNCaP cells.
Cancer science 2004;95(3):271-5.
2004: Takashi Kumagai; Takayuki Ikezoe; Dorina Gui; James O'Kelly; Xiang-Jun Tong; Fredric Cohen; Jonathan W Said; H Phillip Koeffler
RWJ-241947 (MCC-555), a unique peroxisome proliferator-activated receptor-gamma ligand with antitumor activity against human prostate cancer in vitro and in beige/nude/ X-linked immunodeficient mice and enhancement of apoptosis in myeloma cells induced by arsenic trioxide.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(4):1508-20.
2004: Yang Yang; Takayuki Ikezoe; Tsuyako Saito; Makoto Kobayashi; H Phillip Koeffler; Hirokuni Taguchi
Proteasome inhibitor PS-341 induces growth arrest and apoptosis of non-small cell lung cancer cells via the JNK/c-Jun/AP-1 signaling.
Cancer science 2004;95(2):176-80.
2004: Noriyuki Takai; Julian C Desmond; Takashi Kumagai; Dorina Gui; Jonathan W Said; Sadie Whittaker; Isao Miyakawa; H Phillip Koeffler
Histone deacetylase inhibitors have a profound antigrowth activity in endometrial cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(3):1141-9.
2004: Masaaki Shiohara; Adrian F Gombart; Yukio Sekiguchi; Eiko Hidaka; Susumu Ito; Takashi Yamazaki; H Phillip Koeffler; Atsushi Komiyama
Phenotypic and functional alterations of peripheral blood monocytes in neutrophil-specific granule deficiency.
Journal of leukocyte biology 2004;75(2):190-7.
2004: Sigal Gery; Adrian F Gombart; Yuen K Fung; H Phillip Koeffler
C/EBPepsilon interacts with retinoblastoma and E2F1 during granulopoiesis.
Blood 2004;103(3):828-35.
2004: Kuk-Wha Lee; Bingrong Liu; Liqun Ma; Heju Li; Peter Bang; H Phillip Koeffler; Pinchas Cohen
Cellular internalization of insulin-like growth factor binding protein-3: distinct endocytic pathways facilitate re-uptake and nuclear localization.
The Journal of biological chemistry 2004;279(1):469-76.
2004: Tiziana Servidei; Roberta Morosetti; Ferlini Cristiano; Gabriella Cusano; Giovanni Scambia; Renato Mastrangelo; H Phillip Koeffler
The cellular response to PPARgamma ligands is related to the phenotype of neuroblastoma cell lines.
Oncology research 2004;14(7-8):345-54.
2004: Mathias J Rummel; Sven de Vos; Dieter Hoelzer; H Phillip Koeffler; Wolf-Karsten Hofmann
Altered apoptosis pathways in mantle cell lymphoma.
Leukemia & lymphoma 2004;45(1):49-54.
2003: Sigal Tavor; Dorothy J Park; Sigal Gery; Peter T Vuong; Adrian F Gombart; H Phillip Koeffler
Restoration of C/EBPalpha expression in a BCR-ABL+ cell line induces terminal granulocytic differentiation.
The Journal of biological chemistry 2003;278(52):52651-9.
2003: Takayuki Ikezoe; Yang Yang; David Heber; Hirokuni Taguchi; H Phillip Koeffler
PC-SPES: a potent inhibitor of nuclear factor-kappa B rescues mice from lipopolysaccharide-induced septic shock.
Molecular pharmacology 2003;64(6):1521-9.
2003: Dorothy J Park; Peter T Vuong; Sven de Vos; Dan Douer; H Phillip Koeffler
Comparative analysis of genes regulated by PML/RAR alpha and PLZF/RAR alpha in response to retinoic acid using oligonucleotide arrays.
Blood 2003;102(10):3727-36.
2003: Chuanbing Zang; Marlies Wächter; Hongyu Liu; Maximilian Posch; Martin Fenner; Christine Stadelmann; Andreas von Deimling; Kurt Possinger; Keith L Black; H Phillip Koeffler; Elena Elstner
Ligands for PPARgamma and RAR cause induction of growth inhibition and apoptosis in human glioblastomas.
Journal of neuro-oncology 2003;65(2):107-18.
2003: Takayuki Ikezoe; Sophie S Chen; Yang Yang; David Heber; Hirokuni Taguchi; H Phillip Koeffler
PC-SPES: Molecular mechanism to induce apoptosis and down-regulate expression of PSA in LNCaP human prostate cancer cells.
International journal of oncology 2003;23(5):1461-70.
2003: Seisho Takeuchi; Taku Seriu; Jacques J M van Dongen; Tomasz Szczepański; Kunihiro Tsukasaki; Naoko Takeuchi; Anthony C Fermin; Hiromi Seo; Claus R Bartram; H Phillip Koeffler
Allelotype analysis in relapsed childhood acute lymphoblastic leukemia.
Oncogene 2003;22(44):6970-6.
2003: Takayuki Ikezoe; Sophie Chen; Tsuyako Saito; Hiroya Asou; Taiichi Kyo; Sakae Tanosaki; David Heber; Hirokuni Taguchi; H Phillip Koeffler
PC-SPES decreases proliferation and induces differentiation and apoptosis of human acute myeloid leukemia cells.
International journal of oncology 2003;23(4):1203-11.
2003: Takayuki Ikezoe; Sophie S Chen; Xian-Jun Tong; David Heber; Hirokuni Taguchi; H Phillip Koeffler
Oridonin induces growth inhibition and apoptosis of a variety of human cancer cells.
International journal of oncology 2003;23(4):1187-93.
2003: Eisuke Uehara; Seisho Takeuchi; Taizo Tasaka; Yoshiko Matsuhashi; Yang Yang; Mitsuhiro Fujita; Takahiro Tamura; Masami Nagai; H Phillip Koeffler
Aberrant methylation in promoter-associated CpG islands of multiple genes in therapy-related leukemia.
International journal of oncology 2003;23(3):693-6.
2003: Takayuki Ikezoe; Seisho Takeuchit; Naoki Komatsu; Miyuki Okada; Atsuki Fukushima; Hisayuki Ueno; H Phillip Koeffler; Hirokuni Taguchi
Identification of a new GLC1A mutation in a sporadic, primary open-angle glaucoma in Japan.
International journal of molecular medicine 2003;12(2):259-61.
2003: Wenwen Chien; Nicola Tidow; Elizabeth A Williamson; Lee-Yung Shih; Utz Krug; Arminja Kettenbach; Anthony C Fermin; Chaim M Roifman; H Phillip Koeffler
Characterization of a myeloid tyrosine phosphatase, Lyp, and its role in the Bcr-Abl signal transduction pathway.
The Journal of biological chemistry 2003;278(30):27413-20.
2003: Wolf-Karsten Hofmann; Martina Komor; Barbara Wassmann; Letetia C Jones; Harald Gschaidmeier; Dieter Hoelzer; H Phillip Koeffler; Oliver G Ottmann
Presence of the BCR-ABL mutation Glu255Lys prior to STI571 (imatinib) treatment in patients with Ph+ acute lymphoblastic leukemia.
Blood 2003;102(2):659-61.
2003: Naoki Mori; Roberta Morosetti; Hideaki Mizoguchi; H Phillip Koeffler
Progression of myelodysplastic syndrome: allelic loss on chromosomal arm 1p.
British journal of haematology 2003;122(2):226-30.
2003: Takashi Kumagai; James O'Kelly; Jonathan W Said; H Phillip Koeffler
Vitamin D2 analog 19-nor-1,25-dihydroxyvitamin D2: antitumor activity against leukemia, myeloma, and colon cancer cells.
Journal of the National Cancer Institute 2003;95(12):896-905.
2003: Richard H Weisbart; Carl W Miller; Grace Chan; Rika Wakelin; Kevin Ferreri; H Phillip Koeffler
Nuclear delivery of p53 C-terminal peptides into cancer cells using scFv fragments of a monoclonal antibody that penetrates living cells.
Cancer letters 2003;195(2):211-9.
2003: Sakae Tanosaki; Takayuki Ikezoe; Anthony Heaney; Jonathan W Said; Kazuo Dan; Makoto Akashi; H Phillip Koeffler
Effect of ligands of nuclear hormone receptors on sodium/iodide symporter expression and activity in breast cancer cells.
Breast cancer research and treatment 2003;79(3):335-45.
2003: Xiangjun Tong; Dong Xie; Wilfried Roth; John Reed; H Phillip Koeffler
NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo.
International journal of oncology 2003;22(6):1357-62.
2003: Sigal Gery; H Phillip Koeffler
Repression of the TMEFF2 promoter by c-Myc.
Journal of molecular biology 2003;328(5):977-83.
2003: Sigal Gery; Dong Yin; Dong Xie; Keith L Black; H Phillip Koeffler
TMEFF1 and brain tumors.
Oncogene 2003;22(18):2723-7.
2003: Adrian F Gombart; Scott H Kwok; Karen L Anderson; Yuji Yamaguchi; Bruce E Torbett; H Phillip Koeffler
Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C/EBP epsilon and PU.1.
Blood 2003;101(8):3265-73.
2003: Seisho Takeuchi; Naoko Takeuchi; Kunihiro Tsukasaki; Anthony C Fermin; Sven De Vas; Hiromi Seo; H Phillip Koeffler
Mutations in the retinoblastoma-related gene RB2/p130 in adult T-cell leukaemia/lymphoma.
Leukemia & lymphoma 2003;44(4):699-701.
2003: Naoki Mori; Rong Yang; Norihiko Kawamata; Carl W Miller; Hideaki Mizoguchi; H Phillip Koeffler
Absence of R24C mutation of the CDK4 gene in leukemias and solid tumors.
International journal of hematology 2003;77(3):259-62.
2003: Seisho Takeuchi; Naoko Takeuchi; Anthony C Fermin; Hirokuni Taguchi; H Phillip Koeffler
Frameshift mutations in caspase-5 and other target genes in leukemia and lymphoma cell lines having microsatellite instability.
Leukemia research 2003;27(4):359-61.
2003: Sven de Vos; Utz Krug; Wolf-Karsten Hofmann; Geraldine S Pinkus; Steven H Swerdlow; William Wachsman; Thomas M Grogan; Jonathan W Said; H Phillip Koeffler
Cell cycle alterations in the blastoid variant of mantle cell lymphoma (MCL-BV) as detected by gene expression profiling of mantle cell lymphoma (MCL) and MCL-BV.
Diagnostic molecular pathology : the American journal of surgical pathology, part B 2003;12(1):35-43.
2003: Carsten Müller-Tidow; Carol Readhead; Arthur H Cohen; Kamlesh Asotra; Gregory E Idos; Sven Diederichs; Thomas Cauvet; Rong Yang; Wolfgang E Berdel; Hubert Serve; H Phillip Koeffler
Successive increases in human cyclin A1 promoter activity during spermatogenesis in transgenic mice.
International journal of molecular medicine 2003;11(3):311-5.
2003: Sven de Vos; Wolf-Karsten Hofmann; Thomas M Grogan; Utz Krug; Matthew Schrage; Thomas P Miller; Jonathan G Braun; William Wachsman; H Phillip Koeffler; Jonathan W Said
Gene expression profile of serial samples of transformed B-cell lymphomas.
Laboratory investigation; a journal of technical methods and pathology 2003;83(2):271-85.
2003: A Kaeferstein; Utz Krug; Jens Tiesmeier; M Aivado; M Faulhaber; M Stadler; Jürgen Krauter; U Germing; Wolf-Karsten Hofmann; H Phillip Koeffler; Arnold Ganser; Walter Verbeek
The emergence of a C/EBPalpha mutation in the clonal evolution of MDS towards secondary AML.
Leukemia 2003;17(2):343-9.
2003: Hiroya Asou; Adrian F Gombart; Seisho Takeuchi; Hideo Tanaka; Maki Tanioka; Hirotaka Matsui; Akiro Kimura; Toshiya Inaba; H Phillip Koeffler
Establishment of the acute myeloid leukemia cell line Kasumi-6 from a patient with a dominant-negative mutation in the DNA-binding region of the C/EBPalpha gene.
Genes, chromosomes & cancer 2003;36(2):167-74.
2003: Bao-Tran H Truong; Young-Jin Lee; Tracey A Lodie; Dorothy J Park; Danilo Perrotti; Naohide Watanabe; H Phillip Koeffler; Hideaki Nakajima; Daniel G Tenen; Scott C Kogan
CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia.
Blood 2003;101(3):1141-8.
2003: James O'Kelly; H Phillip Koeffler
Vitamin D analogs and breast cancer.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 2003;164():333-48.
2003: H Phillip Koeffler
Peroxisome proliferator-activated receptor gamma and cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(1):1-9.
2003: Seisho Takeuchi; Kunihiro Tsukasaki; Claus R Bartram; Taku Seriu; M Zimmermann; M Schrappe; Naoko Takeuchi; S Park; Hirokuni Taguchi; H Phillip Koeffler
Long-term study of the clinical significance of loss of heterozygosity in childhood acute lymphoblastic leukemia.
Leukemia 2003;17(1):149-54.
2003: Dong Yin; Dong Xie; Wolf-Karsten Hofmann; Wenxuan Zhang; Kamlesh Asotra; Rex Wong; Keith L Black; H Phillip Koeffler
DNA repair gene O6-methylguanine-DNA methyltransferase: promoter hypermethylation associated with decreased expression and G:C to A:T mutations of p53 in brain tumors.
Molecular carcinogenesis 2003;36(1):23-31.
2002: Seisho Takeuchi; Naoko Takeuchi; Kunihiro Tsukasaki; Claus R Bartram; Martin Zimmermann; Martin Schrappe; Hirokuni Taguchi; H Phillip Koeffler
Genetic polymorphisms in the tumour necrosis factor locus in childhood acute lymphoblastic leukaemia.
British journal of haematology 2002;119(4):985-7.
2002: Dong Yin; Dong Xie; Wolf-Karsten Hofmann; Carl W Miller; Keith L Black; H Phillip Koeffler
Methylation, expression, and mutation analysis of the cell cycle control genes in human brain tumors.
Oncogene 2002;21(54):8372-8.
2002: Wolf-Karsten Hofmann; Sven de Vos; Martina Komor; Dieter Hoelzer; William Wachsman; H Phillip Koeffler
Characterization of gene expression of CD34+ cells from normal and myelodysplastic bone marrow.
Blood 2002;100(10):3553-60.
2002: Vijaya Vegesna; James O'Kelly; Milan Uskokovic; Jonathan Said; Nathan Lemp; Takayuki Saitoh; Takayuki Ikezoe; Lise Binderup; H Phillip Koeffler
Vitamin D3 analogs stimulate hair growth in nude mice.
Endocrinology 2002;143(11):4389-96.
2002: Sergio Huerta; James R Arteaga; Ronald W Irwin; Takayuki Ikezoe; David Heber; H Phillip Koeffler
PC-SPES inhibits colon cancer growth in vitro and in vivo.
Cancer research 2002;62(18):5204-9.
2002: Dong Xie; Anna Jauch; Carl W Miller; Claus R Bartram; H Phillip Koeffler
Discovery of over-expressed genes and genetic alterations in breast cancer cells using a combination of suppression subtractive hybridization, multiplex FISH and comparative genomic hybridization.
International journal of oncology 2002;21(3):499-507.
2002: Robert E Fleming; John R Ahmann; Mary C Migas; Abdul Waheed; H Phillip Koeffler; Hiroshi Kawabata; Robert S Britton; Bruce R Bacon; William S Sly
Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10653-8.
2002: Wolf-Karsten Hofmann; H Phillip Koeffler
Important features of myelodysplastic syndrome.
International journal of hematology 2002;76 Suppl 2():222-7.
2002: Wolf-Karsten Hofmann; Xiang-Jun Tong; Richard S Ajioka; James P Kushner; H Phillip Koeffler
Mutation analysis of transferrin-receptor 2 in patients with atypical hemochromatosis.
Blood 2002;100(3):1099-100.
2002: Sigal Gery; Charles L Sawyers; David B Agus; Jonathan W Said; H Phillip Koeffler
TMEFF2 is an androgen-regulated gene exhibiting antiproliferative effects in prostate cancer cells.
Oncogene 2002;21(31):4739-46.
2002: Elena Elstner; Elizabeth A Williamson; Chuanbing Zang; J Fritz; D Heber; Martin Fenner; Kurt Possinger; H Phillip Koeffler
Novel therapeutic approach: ligands for PPARgamma and retinoid receptors induce apoptosis in bcl-2-positive human breast cancer cells.
Breast cancer research and treatment 2002;74(2):155-65.
2002: Utz Krug; Arnold Ganser; H Phillip Koeffler
Tumor suppressor genes in normal and malignant hematopoiesis.
Oncogene 2002;21(21):3475-95.
2002: Elizabeth A Williamson; Farnaz Dadmanesh; H Phillip Koeffler
BRCA1 transactivates the cyclin-dependent kinase inhibitor p27(Kip1).
Oncogene 2002;21(20):3199-206.
2002: Vijaya Vegesna; Seisho Takeuchi; Wolf-Karsten Hofmann; Takayuki Ikezoe; Sigal Tavor; Utz Krug; Anthony C Fermin; Anthony Heaney; Carl W Miller; H Phillip Koeffler
C/EBP-beta, C/EBP-delta, PU.1, AML1 genes: mutational analysis in 381 samples of hematopoietic and solid malignancies.
Leukemia research 2002;26(5):451-7.
2002: James O'Kelly; Junichi Hisatake; Yasuko Hisatake; June Bishop; Anthony Norman; H Phillip Koeffler
Normal myelopoiesis but abnormal T lymphocyte responses in vitamin D receptor knockout mice.
The Journal of clinical investigation 2002;109(8):1091-9.
2002: Wolf-Karsten Hofmann; H Phillip Koeffler
Differentiation therapy for myelodysplastic syndrome.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(4):939-41.
2002: Wolf-Karsten Hofmann; Seisho Takeuchi; Malka A Frantzen; Dieter Hoelzer; H Phillip Koeffler
Loss of genomic imprinting of insulin-like growth factor 2 is strongly associated with cellular proliferation in normal hematopoietic cells.
Experimental hematology 2002;30(4):318-23.
2002: Letetia C Jones; Meng-Liang Lin; Shih-Shun Chen; Utz Krug; Wolf-Karsten Hofmann; Stephen Lee; Ying-Hue Lee; H Phillip Koeffler
Expression of C/EBPbeta from the C/ebpalpha gene locus is sufficient for normal hematopoiesis in vivo.
Blood 2002;99(6):2032-6.
2002: Wolf-Karsten Hofmann; Letetia C Jones; Nathan Lemp; Sven de Vos; Harald Gschaidmeier; Dieter Hoelzer; Oliver G Ottmann; H Phillip Koeffler
Ph(+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation.
Blood 2002;99(5):1860-2.
2002: Sigal Tavor; Peter T Vuong; Dorothy J Park; Adrian F Gombart; Arthur H Cohen; H Phillip Koeffler
Macrophage functional maturation and cytokine production are impaired in C/EBP epsilon-deficient mice.
Blood 2002;99(5):1794-801.
2002: Woo Hyun Park; Jae Goo Seol; Eun Shil Kim; Lise Binderup; H Phillip Koeffler; Byoung Kook Kim; Young Yiul Lee
The induction of apoptosis by a combined 1,25(OH)2D3 analog, EB1089 and TGF-beta1 in NCI-H929 multiple myeloma cells.
International journal of oncology 2002;20(3):533-42.
2002: Adrian F Gombart; Wolf-Karsten Hofmann; Seiji Kawano; Seisho Takeuchi; Utz Krug; Scott H Kwok; Renee J Larsen; Hiroya Asou; Carl W Miller; Dieter Hoelzer; H Phillip Koeffler
Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias.
Blood 2002;99(4):1332-40.
2002: Wolf-Karsten Hofmann; Sven de Vos; David Elashoff; Harald Gschaidmeier; Dieter Hoelzer; H Phillip Koeffler; Oliver G Ottmann
Relation between resistance of Philadelphia-chromosome-positive acute lymphoblastic leukaemia to the tyrosine kinase inhibitor STI571 and gene-expression profiles: a gene-expression study.
Lancet 2002;359(9305):481-6.
2002: Xiangjun Tong; Hiroshi Kawabata; H Phillip Koeffler
Iron deficiency can upregulate expression of transferrin receptor at both the mRNA and protein level.
British journal of haematology 2002;116(2):458-64.
2002: Sergio Huerta; Ronald W Irwin; David Heber; Vay Liang W Go; H Phillip Koeffler; Milan R Uskokovic; Diane M Harris
1alpha,25-(OH)(2)-D(3) and its synthetic analogue decrease tumor load in the Apc(min) Mouse.
Cancer research 2002;62(3):741-6.
2002: Adrian F Gombart; H Phillip Koeffler
Neutrophil specific granule deficiency and mutations in the gene encoding transcription factor C/EBP(epsilon).
Current opinion in hematology 2002;9(1):36-42.
2002: Carl W Miller; Takayuki Ikezoe; Utz Krug; Wolf-Karsten Hofmann; Sigal Tavor; Vijaya Vegesna; Kunihiro Tsukasaki; Seisho Takeuchi; H Phillip Koeffler
Mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors.
Genes, chromosomes & cancer 2002;33(1):17-21.
2001: Dong Xie; K Nakachi; H Wang; R Elashoff; H Phillip Koeffler
Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features.
Cancer research 2001;61(24):8917-23.
2001: X Tong; D Xie; James O'Kelly; Carl W Miller; C Muller-Tidow; H Phillip Koeffler
Cyr61, a member of CCN family, is a tumor suppressor in non-small cell lung cancer.
The Journal of biological chemistry 2001;276(50):47709-14.
2001: T Ikezoe; S S Chen; David Heber; Hirokuni Taguchi; H Phillip Koeffler
Baicalin is a major component of PC-SPES which inhibits the proliferation of human cancer cells via apoptosis and cell cycle arrest.
The Prostate 2001;49(4):285-92.
2001: Hiroshi Kawabata; T Nakamaki; P Ikonomi; R D Smith; RS Germain; H Phillip Koeffler
Expression of transferrin receptor 2 in normal and neoplastic hematopoietic cells.
Blood 2001;98(9):2714-9.
2001: T Kubota; Toshiyasu Hirama; W Verbeek; Seiji Kawano; Doris Y Chih; Alexey Chumakov; Hirokuni Taguchi; H Phillip Koeffler
DNase I hypersensitivity analysis of the human CCAAT enhancer binding protein epsilon (C/EBPepsilon) gene.
Leukemia research 2001;25(11):981-95.
2001: Wolf-Karsten Hofmann; Seisho Takeuchi; D Xie; Carl W Miller; Dieter Hoelzer; H Phillip Koeffler
Frequent loss of heterozygosity in the region of D1S450 at 1p36.2 in myelodysplastic syndromes.
Leukemia research 2001;25(10):855-8.
2001: Hiroshi Kawabata; RS Germain; Takayuki Ikezoe; Xiangjun Tong; E M Green; Adrian F Gombart; H Phillip Koeffler
Regulation of expression of murine transferrin receptor 2.
Blood 2001;98(6):1949-54.
2001: Wolf-Karsten Hofmann; Kunihiro Tsukasaki; N Takeuchi; Seisho Takeuchi; H Phillip Koeffler
Methylation analysis of cell cycle control genes in adult T-cell leukemia/lymphoma.
Leukemia & lymphoma 2001;42(5):1107-9.
2001: Wolf-Karsten Hofmann; Sven de Vos; Kunihiro Tsukasaki; William Wachsman; Geraldine S Pinkus; Jonathan W Said; H Phillip Koeffler
Altered apoptosis pathways in mantle cell lymphoma detected by oligonucleotide microarray.
Blood 2001;98(3):787-94.
2001: Sigal Tavor; Seisho Takeuchi; Kunihiro Tsukasaki; Carl W Miller; Wolf-Karsten Hofmann; Takayuki Ikezoe; J W Said; H Phillip Koeffler
Analysis of the CHK2 gene in lymphoid malignancies.
Leukemia & lymphoma 2001;42(3):517-20.
2001: Takayuki Ikezoe; Carl W Miller; S Kawano; Anthony Heaney; Elizabeth A Williamson; Junichi Hisatake; E Green; W Hofmann; Hirokuni Taguchi; H Phillip Koeffler
Mutational analysis of the peroxisome proliferator-activated receptor gamma gene in human malignancies.
Cancer research 2001;61(13):5307-10.
2001: Kunihiro Tsukasaki; J Krebs; K Nagai; Masao Tomonaga; H Phillip Koeffler; Claus R Bartram; Anna Jauch
Comparative genomic hybridization analysis in adult T-cell leukemia/lymphoma: correlation with clinical course.
Blood 2001;97(12):3875-81.
2001: Kunihiro Tsukasaki; Carl W Miller; E Greenspun; S Eshaghian; H Kawabata; T Fujimoto; Masao Tomonaga; Charles L Sawyers; Jonathan W Said; H Phillip Koeffler
Mutations in the mitotic check point gene, MAD1L1, in human cancers.
Oncogene 2001;20(25):3301-5.
2001: J G Tang; H Phillip Koeffler
Structural and functional studies of CCAAT/enhancer-binding protein epsilon.
The Journal of biological chemistry 2001;276(21):17739-46.
2001: Kunihiro Tsukasaki; Carl W Miller; T Kubota; Seisho Takeuchi; T Fujimoto; S Ikeda; Masao Tomonaga; H Phillip Koeffler
Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers.
Cancer research 2001;61(9):3770-4.
2001: Adrian F Gombart; Masaaki Shiohara; Scott H Kwok; K Agematsu; A Komiyama; H Phillip Koeffler
Neutrophil-specific granule deficiency: homozygous recessive inheritance of a frameshift mutation in the gene encoding transcription factor CCAAT/enhancer binding protein--epsilon.
Blood 2001;97(9):2561-7.
2001: D Xie; Carl W Miller; James O'Kelly; K Nakachi; Akiko Sakashita; Jonathan W Said; J Gornbein; H Phillip Koeffler
Breast cancer. Cyr61 is overexpressed, estrogen-inducible, and associated with more advanced disease.
The Journal of biological chemistry 2001;276(17):14187-94.
2001: Masaaki Shiohara; Milan Uskokovic; Junichi Hisatake; Yasuko Hisatake; K Koike; A Komiyama; H Phillip Koeffler
24-Oxo metabolites of vitamin D3 analogues: disassociation of their prominent antileukemic effects from their lack of calcium modulation.
Cancer research 2001;61(8):3361-8.
2001: Junichi Hisatake; James O'Kelly; Milan Uskokovic; Shigeru Tomoyasu; H Phillip Koeffler
Novel vitamin D(3) analog, 21-(3-methyl-3-hydroxy-butyl)-19-nor D(3), that modulates cell growth, differentiation, apoptosis, cell cycle, and induction of PTEN in leukemic cells.
Blood 2001;97(8):2427-33.
2001: M Linker-Israeli; E Elstner; JR Klinenberg; Daniel J Wallace; H Phillip Koeffler
Vitamin D(3) and its synthetic analogs inhibit the spontaneous in vitro immunoglobulin production by SLE-derived PBMC.
Clinical immunology (Orlando, Fla.) 2001;99(1):82-93.
2001: Carsten Müller-Tidow; Wenbing Wang; Gregory E Idos; Sven Diederichs; Rong Yang; Carol Readhead; Wolfgang E Berdel; Hubert Serve; M Saville; R Watson; H Phillip Koeffler
Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function.
Blood 2001;97(7):2091-7.
2001: Wolf-Karsten Hofmann; Carl W Miller; Kunihiro Tsukasaki; Sigal Tavor; Takayuki Ikezoe; Dieter Hoelzer; Seisho Takeuchi; H Phillip Koeffler
Mutation analysis of the DNA-damage checkpoint gene CHK2 in myelodysplastic syndromes and acute myeloid leukemias.
Leukemia research 2001;25(4):333-8.
2001: Carsten Müller-Tidow; Ralf Metzger; K Kügler; Sven Diederichs; Gregory E Idos; Michael Thomas; Barbara Dockhorn-Dworniczak; Paul M Schneider; H Phillip Koeffler; Wolfgang E Berdel; Hubert Serve
Cyclin E is the only cyclin-dependent kinase 2-associated cyclin that predicts metastasis and survival in early stage non-small cell lung cancer.
Cancer research 2001;61(2):647-53.
2001: W Verbeek; M Wächter; J Lekstrom-Himes; H Phillip Koeffler
C/EBPepsilon -/- mice: increased rate of myeloid proliferation and apoptosis.
Leukemia 2001;15(1):103-11.
2000: T Kubota; Seiji Kawano; Doris Y Chih; Yasuko Hisatake; Alexey Chumakov; Hirokuni Taguchi; H Phillip Koeffler
Representational difference analysis using myeloid cells from C/EBP epsilon deletional mice.
Blood 2000;96(12):3953-7.
2000: C Müller; Rong Yang; Dorothy J Park; Hubert Serve; Wolfgang E Berdel; H Phillip Koeffler
The aberrant fusion proteins PML-RAR alpha and PLZF-RAR alpha contribute to the overexpression of cyclin A1 in acute promyelocytic leukemia.
Blood 2000;96(12):3894-9.
2000: Takayuki Ikezoe; Eric S Daar; Junichi Hisatake; Hirokuni Taguchi; H Phillip Koeffler
HIV-1 protease inhibitors decrease proliferation and induce differentiation of human myelocytic leukemia cells.
Blood 2000;96(10):3553-9.
2000: Moray J Campbell; Adrian F Gombart; Scott H Kwok; S Park; H Phillip Koeffler
The anti-proliferative effects of 1alpha,25(OH)2D3 on breast and prostate cancer cells are associated with induction of BRCA1 gene expression.
Oncogene 2000;19(44):5091-7.
2000: Junichi Hisatake; Takayuki Ikezoe; M Carey; S Holden; S Tomoyasu; H Phillip Koeffler
Down-Regulation of prostate-specific antigen expression by ligands for peroxisome proliferator-activated receptor gamma in human prostate cancer.
Cancer research 2000;60(19):5494-8.
2000: Anthony W Norman; Percy Manchand; Milan R Uskokovic; William H Okamura; J A Takeuchi; June E Bishop; Junichi Hisatake; H Phillip Koeffler; Sara Peleg
Characterization of a novel analogue of 1alpha,25(OH)(2)-vitamin D(3) with two side chains: interaction with its nuclear receptor and cellular actions.
Journal of medicinal chemistry 2000;43(14):2719-30.
2000: Hiroshi Kawabata; RS Germain; Peter T Vuong; T Nakamaki; J W Said; H Phillip Koeffler
Transferrin receptor 2-alpha supports cell growth both in iron-chelated cultured cells and in vivo.
The Journal of biological chemistry 2000;275(22):16618-25.
2000: N Mori; Roberta Morosetti; E Hoflehner; M Lübbert; H Mizoguchi; H Phillip Koeffler
Allelic loss in the progression of myelodysplastic syndrome.
Cancer research 2000;60(11):3039-42.
2000: D Xie; Wolf-Karsten Hofmann; N Mori; Carl W Miller; Dieter Hoelzer; H Phillip Koeffler
Allelotype analysis of the myelodysplastic syndrome.
Leukemia 2000;14(5):805-10.
2000: C Müller; Carol Readhead; Sven Diederichs; Gregory E Idos; Rong Yang; Nicola Tidow; Hubert Serve; Wolfgang E Berdel; H Phillip Koeffler
Methylation of the cyclin A1 promoter correlates with gene silencing in somatic cell lines, while tissue-specific expression of cyclin A1 is methylation independent.
Molecular and cellular biology 2000;20(9):3316-29.
2000: E A Smith; Elizabeth P Frankenburg; Steven A Goldstein; Kozo Koshizuka; Elena Elstner; Jonathan Said; T Kubota; Milan Uskokovic; H Phillip Koeffler
Effects of long-term administration of vitamin D3 analogs to mice.
The Journal of endocrinology 2000;165(1):163-72.
2000: Naoki Komatsu; Seisho Takeuchi; Takayuki Ikezoe; Taizo Tasaka; Y Hatta; H Machida; I K Williamson; Claus R Bartram; H Phillip Koeffler; Hirokuni Taguchi
Mutations of the E2F4 gene in hematological malignancies having microsatellite instability.
Blood 2000;95(4):1509-10.
2000: T Kubota; Junichi Hisatake; Yasuko Hisatake; Jonathan W Said; S S Chen; S Holden; Hirokuni Taguchi; H Phillip Koeffler
PC-SPES: a unique inhibitor of proliferation of prostate cancer cells in vitro and in vivo .
The Prostate 2000;42(3):163-71.
2000: Alexey Chumakov; E A Chumakova; Doris Y Chih; H Phillip Koeffler
Molecular analysis of the human myeloperoxidase promoter region.
International journal of oncology 2000;16(2):401-11.
2000: Jae Goo Seol; Woo Hyun Park; Eun Shil Kim; Chul Won Jung; L Binderup; H Phillip Koeffler; Byoung Kook Kim; Young Yiul Lee
Effect of a novel vitamin D3 analog, EB1089, on G1 cell cycle regulatory proteins in HL-60 cells.
International journal of oncology 2000;16(2):315-20.
2000: K Koshiuka; E Elstner; E Williamson; J W Said; Y Tada; H Phillip Koeffler
Novel therapeutic approach: organic arsenical melarsoprol) alone or with all-trans-retinoic acid markedly inhibit growth of human breast and prostate cancer cells in vitro and in vivo.
British journal of cancer 2000;82(2):452-8.
2000: Hiroya Asou; Taizo Tasaka; Jonathan W Said; M Daibata; Nanao Kamada; H Phillip Koeffler
Co-infection of HHV-6 and HHV-8 is rare in primary effusion lymphoma.
Leukemia research 2000;24(1):59-61.
1999: C Müller; Rong Yang; Gregory E Idos; Nicola Tidow; Sven Diederichs; O M Koch; W Verbeek; T P Bender; H Phillip Koeffler
c-myb transactivates the human cyclin A1 promoter and induces cyclin A1 gene expression.
Blood 1999;94(12):4255-62.
1999: Seisho Takeuchi; S K Cho; Taku Seriu; M Koike; Claus R Bartram; A Reiter; Martin Schrappe; C Takeuchi; Hirokuni Taguchi; H Phillip Koeffler
Identification of three distinct regions of deletion on the long arm of chromosome 11 in childhood acute lymphoblastic leukemia.
Oncogene 1999;18(51):7387-8.
1999: W Verbeek; J Lekstrom-Himes; D J Park; Pham My-Chan Dang; P T Vuong; Seiji Kawano; Bernard M Babior; Kleanthis G Xanthopoulos; H Phillip Koeffler
Myeloid transcription factor C/EBPepsilon is involved in the positive regulation of lactoferrin gene expression in neutrophils.
Blood 1999;94(9):3141-50.
1999: Hiroya Asou; W Verbeek; E Williamson; E Elstner; T Kubota; Nanao Kamada; H Phillip Koeffler
Growth inhibition of myeloid leukemia cells by troglitazone, a ligand for peroxisome proliferator activated receptor gamma, and retinoids.
International journal of oncology 1999;15(5):1027-31.
1999: Junichi Hisatake; T Kubota; Yasuko Hisatake; Milan Uskokovic; Shigeru Tomoyasu; H Phillip Koeffler
5,6-trans-16-ene-vitamin D3: a new class of potent inhibitors of proliferation of prostate, breast, and myeloid leukemic cells.
Cancer research 1999;59(16):4023-9.
1999: S Kawano; Carl W Miller; Adrian F Gombart; C R Bartram; Y Matsuo; Hiroya Asou; Akiko Sakashita; Jonathan Said; E Tatsumi; H Phillip Koeffler
Loss of p73 gene expression in leukemias/lymphomas due to hypermethylation.
Blood 1999;94(3):1113-20.
1999: Elena Elstner; MJ Campbell; R Munker; Peter Shintaku; Lise Binderup; David Heber; Jonathan Said; H Phillip Koeffler
Novel 20-epi-vitamin D3 analog combined with 9-cis-retinoic acid markedly inhibits colony growth of prostate cancer cells.
The Prostate 1999;40(3):141-9.
1999: Toshiyasu Hirama; Carl W Miller; H Phillip Koeffler
Translocon-associated protein alpha transcripts are induced by granulocyte-macrophage colony-stimulating factor and exhibit complex alternative polyadenylation.
FEBS letters 1999;455(3):223-7.
1999: Hiroshi Kawabata; R Yang; Toshiyasu Hirama; Peter T Vuong; Seiji Kawano; Adrian F Gombart; H Phillip Koeffler
Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family.
The Journal of biological chemistry 1999;274(30):20826-32.
1999: Dorothy J Park; Alexey Chumakov; Peter T Vuong; Doris Y Chih; Adrian F Gombart; W H Miller; H Phillip Koeffler
CCAAT/enhancer binding protein epsilon is a potential retinoid target gene in acute promyelocytic leukemia treatment.
The Journal of clinical investigation 1999;103(10):1399-408.
1999: W Verbeek; Adrian F Gombart; Alexey Chumakov; C Müller; Alan D Friedman; H Phillip Koeffler
C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters.
Blood 1999;93(10):3327-37.
1999: M Koike; Kozo Koshizuka; H Kawabata; Rong Yang; HE Taub; Jonathan Said; Milan Uskokovic; N Tsuruoka; H Phillip Koeffler
20-Cyclopropyl-cholecalciferol vitamin D3 analogs: a unique class of potent inhibitors of proliferation of human prostate, breast and myeloid leukemia cell lines.
Anticancer research 1999;19(3A):1689-97.
1999: C Müller; Rong Yang; L Beck-von-Peccoz; Gregory E Idos; W Verbeek; H Phillip Koeffler
Cloning of the cyclin A1 genomic structure and characterization of the promoter region. GC boxes are essential for cell cycle-regulated transcription of the cyclin A1 gene.
The Journal of biological chemistry 1999;274(16):11220-8.
1999: Rong Yang; Tsuyoshi Nakamaki; M Lübbert; Jonathan Said; Akiko Sakashita; B S Freyaldenhoven; S Spira; Vu N Huynh; C Müller; H Phillip Koeffler
Cyclin A1 expression in leukemia and normal hematopoietic cells.
Blood 1999;93(6):2067-74.
1999: Masaaki Shiohara; Marcia I Dawson; Peter D Hobbs; N Sawai; T Higuchi; Kenichi Koike; Atsushi Komiyama; H Phillip Koeffler
Effects of novel RAR- and RXR-selective retinoids on myeloid leukemic proliferation and differentiation in vitro.
Blood 1999;93(6):2057-66.
1999: Jonathan W Said; I Peter Shintaku; Hiroya Asou; S deVos; J Baker; G Hanson; E Cesarman; Roland G Nador; H Phillip Koeffler
Herpesvirus 8 inclusions in primary effusion lymphoma: report of a unique case with T-cell phenotype.
Archives of pathology & laboratory medicine 1999;123(3):257-60.
1999: M Koike; Taizo Tasaka; S Spira; N Tsuruoka; H Phillip Koeffler
Allelotyping of acute myelogenous leukemia: loss of heterozygosity at 7q31.1 (D7S486) and q33-34 (D7S498, D7S505).
Leukemia research 1999;23(3):307-10.
1999: Rong Yang; C Müller; Vu N Huynh; Y K Fung; Amy Yee; H Phillip Koeffler
Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins.
Molecular and cellular biology 1999;19(3):2400-7.
1999: Y Hatta; Yasuaki Yamada; Masao Tomonaga; I Miyoshi; Jonathan W Said; H Phillip Koeffler
Detailed deletion mapping of the long arm of chromosome 6 in adult T-cell leukemia.
Blood 1999;93(2):613-6.
1999: MJ Campbell; S Park; Milan Uskokovic; Marcia I Dawson; Ling Jong; H Phillip Koeffler
Synergistic inhibition of prostate cancer cell lines by a 19-nor hexafluoride vitamin D3 analogue and anti-activator protein 1 retinoid.
British journal of cancer 1999;79(1):101-7.
1999: Kozo Koshizuka; M Koike; Hiroya Asou; S K Cho; T Stephen; R K Rude; L Binderup; M Uskokovic; H Phillip Koeffler
Combined effect of vitamin D3 analogs and paclitaxel on the growth of MCF-7 breast cancer cells in vivo.
Breast cancer research and treatment 1999;53(2):113-20.
1999: Kozo Koshizuka; T Kubota; Jonathan Said; M Koike; Lise Binderup; Milan Uskokovic; H Phillip Koeffler
Combination therapy of a vitamin D3 analog and all-trans-retinoic acid: effect on human breast cancer in nude mice.
Anticancer research 1999;19(1A):519-24.
1998: Seisho Takeuchi; M Koike; S Park; Taku Seriu; Claus R Bartram; HE Taub; I K Williamson; J Grewal; Hirokuni Taguchi; H Phillip Koeffler
The ATM gene and susceptibility to childhood T-cell acute lymphoblastic leukaemia.
British journal of haematology 1998;103(2):536-8.
1998: N Mori; Roberta Morosetti; S Spira; S Lee; D Ben-Yehuda; G Schiller; Raffaele Landolfi; H Mizoguchi; H Phillip Koeffler
Chromosome band 1p36 contains a putative tumor suppressor gene important in the evolution of chronic myelocytic leukemia.
Blood 1998;92(9):3405-9.
1998: Hiroya Asou; M Koike; Elena Elstner; M Cambell; J Le; Milan Uskokovic; Nanao Kamada; H Phillip Koeffler
19-nor vitamin-D analogs: a new class of potent inhibitors of proliferation and inducers of differentiation of human myeloid leukemia cell lines.
Blood 1998;92(7):2441-9.
1998: Y Hatta; Yasuaki Yamada; Masao Tomonaga; Jonathan W Said; I Miyosi; H Phillip Koeffler
Allelotype analysis of adult T-cell leukemia.
Blood 1998;92(6):2113-7.
1998: Kozo Koshizuka; M Koike; T Kubota; Jonathan Said; L Binderup; H Phillip Koeffler
Novel vitamin D3 analog (CB1093) when combined with paclitaxel and cisplatin inhibit growth of MCF-7 human breast cancer cells in vivo.
International journal of oncology 1998;13(3):421-8.
1998: T Kubota; Kozo Koshizuka; M Koike; Milan Uskokovic; I Miyoshi; H Phillip Koeffler
19-nor-26,27-bishomo-vitamin D3 analogs: a unique class of potent inhibitors of proliferation of prostate, breast, and hematopoietic cancer cells.
Cancer research 1998;58(15):3370-5.
1998: T Kubota; Kozo Koshizuka; Elizabeth A Williamson; Hiroya Asou; Jonathan W Said; S Holden; I Miyoshi; H Phillip Koeffler
Ligand for peroxisome proliferator-activated receptor gamma (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo.
Cancer research 1998;58(15):3344-52.
1998: Elena Elstner; C Müller; Kozo Koshizuka; Elizabeth A Williamson; D Park; Hiroya Asou; Peter Shintaku; Jonathan W Said; David Heber; H Phillip Koeffler
Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(15):8806-11.
1998: Seisho Takeuchi; M Koike; Taku Seriu; Claus R Bartram; Martin Schrappe; A Reiter; S Park; HE Taub; I Kubonishi; I Miyoshi; H Phillip Koeffler
Frequent loss of heterozygosity on the long arm of chromosome 6: identification of two distinct regions of deletion in childhood acute lymphoblastic leukemia.
Cancer research 1998;58(12):2618-23.
1998: Elizabeth A Williamson; H N Xu; Adrian F Gombart; W Verbeek; Alexey Chumakov; Alan D Friedman; H Phillip Koeffler
Identification of transcriptional activation and repression domains in human CCAAT/enhancer-binding protein epsilon.
The Journal of biological chemistry 1998;273(24):14796-804.
1998: Taizo Tasaka; Hiroya Asou; R Munker; Jonathan W Said; James Berenson; Robert A Vescio; M Nagai; J Takahara; H Phillip Koeffler
Methylation of the p16INK4A gene in multiple myeloma.
British journal of haematology 1998;101(3):558-64.
1998: W Verbeek; M Frankel; S Miles; Jonathan Said; H Phillip Koeffler
Seroprevalence of HHV-8 antibodies in HIV-positive homosexual men without Kaposi's sarcoma and their clinical follow-up.
American journal of clinical pathology 1998;109(6):778-83.
1998: Seisho Takeuchi; H Phillip Koeffler; D R Hinton; I Miyoshi; Shlomo Melmed; Ilan Shimon
Mutation and expression analysis of the cyclin-dependent kinase inhibitor gene p27/Kip1 in pituitary tumors.
The Journal of endocrinology 1998;157(2):337-41.
1998: Y Hatta; Yasuaki Yamada; Masao Tomonaga; I Miyoshi; Jonathan W Said; H Phillip Koeffler
Microsatellite instability in adult T-cell leukaemia.
British journal of haematology 1998;101(2):341-4.
1998: MJ Campbell; S Park; Milan Uskokovic; Marcia I Dawson; H Phillip Koeffler
Expression of retinoic acid receptor-beta sensitizes prostate cancer cells to growth inhibition mediated by combinations of retinoids and a 19-nor hexafluoride vitamin D3 analog.
Endocrinology 1998;139(4):1972-80.
1998: Hiroya Asou; Jonathan W Said; R Yang; R Munker; D J Park; Nanao Kamada; H Phillip Koeffler
Mechanisms of growth control of Kaposi's sarcoma-associated herpes virus-associated primary effusion lymphoma cells.
Blood 1998;91(7):2475-81.
1998: S de Vos; D B Kohn; S K Cho; william mcbride; J W Said; H Phillip Koeffler
Immunotherapy against murine leukemia.
Leukemia 1998;12(3):401-5.
1998: MJ Campbell; M Dawson; H Phillip Koeffler
Growth inhibition of DU-145 prostate cancer cells by a Bcl-2 antisense oligonucleotide is enhanced by N-(2-hydroxyphenyl)all-trans retinamide.
British journal of cancer 1998;77(5):739-44.
1997: Y Hatta; K Spirin; Taizo Tasaka; Roberta Morosetti; Jonathan W Said; Yasuaki Yamada; Masao Tomonaga; H Phillip Koeffler
Analysis of p18INK4C in adult T-cell leukaemia and non-Hodgkin's lymphoma.
British journal of haematology 1997;99(3):665-7.
1997: R Munker; Taizo Tasaka; D Park; C W Miller; H Phillip Koeffler
HHV-8 (KSHV) does not establish latency in prostate cancer cell lines.
The Prostate 1997;33(4):286-8.
1997: Jonathan W Said; Matthew B Rettig; K Heppner; Robert A Vescio; Gary J Schiller; HJ Ma; D Belson; A Savage; I Peter Shintaku; H Phillip Koeffler; Hiroya Asou; Geraldine S Pinkus; Jack L Pinkus; Matthew Schrage; E Green; James R Berenson
Localization of Kaposi's sarcoma-associated herpesvirus in bone marrow biopsy samples from patients with multiple myeloma.
Blood 1997;90(11):4278-82.
1997: M Koike; Elena Elstner; MJ Campbell; Hiroya Asou; Milan Uskokovic; N Tsuruoka; H Phillip Koeffler
19-nor-hexafluoride analogue of vitamin D3: a novel class of potent inhibitors of proliferation of human breast cell lines.
Cancer research 1997;57(20):4545-50.
1997: Doris Y Chih; Alexey Chumakov; Dorothy J Park; A G Silla; H Phillip Koeffler
Modulation of mRNA expression of a novel human myeloid-selective CCAAT/enhancer binding protein gene (C/EBP epsilon).
Blood 1997;90(8):2987-94.
1997: Roberta Morosetti; Dorothy J Park; Alexey Chumakov; I Grillier; Masaaki Shiohara; Adrian F Gombart; Tsuyoshi Nakamaki; K Weinberg; H Phillip Koeffler
A novel, myeloid transcription factor, C/EBP epsilon, is upregulated during granulocytic, but not monocytic, differentiation.
Blood 1997;90(7):2591-600.
1997: Seisho Takeuchi; M Koike; Taku Seriu; Claus R Bartram; J Slater; S Park; I Miyoshi; H Phillip Koeffler
Homozygous deletions at 9p21 in childhood acute lymphoblastic leukemia detected by microsatellite analysis.
Leukemia 1997;11(10):1636-40.
1997: Masaaki Shiohara; Adrian F Gombart; J D Berman; K Koike; A Komiyama; H Phillip Koeffler
Cytostatic effect of TNFalpha on cancer cells is independent of p21WAF1.
Oncogene 1997;15(13):1605-9.
1997: W Verbeek; Adrian F Gombart; Masaaki Shiohara; M Campbell; H Phillip Koeffler
Vitamin D receptor: no evidence for allele-specific mRNA stability in cells which are heterozygous for the Taq I restriction enzyme polymorphism.
Biochemical and biophysical research communications 1997;238(1):77-80.
1997: M Koike; Alexey Chumakov; S Takeuchi; Taizo Tasaka; R Yang; Tsuyoshi Nakamaki; N Tsuruoka; H Phillip Koeffler
C/EBP-epsilon: chromosomal mapping and mutational analysis of the gene in leukemia and preleukemia.
Leukemia research 1997;21(9):833-9.
1997: N Mori; Roberta Morosetti; S Lee; S Spira; D Ben-Yehuda; G Schiller; Raffaele Landolfi; H Mizoguchi; H Phillip Koeffler
Allelotype analysis in the evolution of chronic myelocytic leukemia.
Blood 1997;90(5):2010-4.
1997: MJ Campbell; G S Reddy; H Phillip Koeffler
Vitamin D3 analogs and their 24-oxo metabolites equally inhibit clonal proliferation of a variety of cancer cells but have differing molecular effects.
Journal of cellular biochemistry 1997;66(3):413-25.
1997: Masami Nagai; Mitsuhiro Fujita; Minoru Ohmori; S Matsubara; M Taniwaki; S Horiike; Taizo Tasaka; H Phillip Koeffler; Jiro Takahara
Establishment of a novel human B-cell line (OZ) with t(14;18)(q32;q21) and aberrant p53 expression was associated with the homozygous deletions of p15INK4B and p16INK4A genes.
Hematological oncology 1997;15(3):109-19.
1997: C W Miller; Roberta Morosetti; M J Campbell; S Mendoza; H Phillip Koeffler
Integrity of the 1,25-dihydroxyvitamin D3 receptor in bone, lung, and other cancers.
Molecular carcinogenesis 1997;19(4):254-7.
1997: MJ Campbell; Elena Elstner; S Holden; Milan Uskokovic; H Phillip Koeffler
Inhibition of proliferation of prostate cancer cells by a 19-nor-hexafluoride vitamin D3 analogue involves the induction of p21waf1, p27kip1 and E-cadherin.
Journal of molecular endocrinology 1997;19(1):15-27.
1997: Seisho Takeuchi; Taku Seriu; Claus R Bartram; Todd R Golub; A Reiter; I Miyoshi; D G Gilliland; H Phillip Koeffler
TEL is one of the targets for deletion on 12p in many cases of childhood B-lineage acute lymphoblastic leukemia.
Leukemia 1997;11(8):1220-3.
1997: Carl W Miller; C Yeon; A Aslo; Susana Mendoza; U Aytac; H Phillip Koeffler
The p19INK4D cyclin dependent kinase inhibitor gene is altered in osteosarcoma.
Oncogene 1997;15(2):231-5.
1997: Jonathan W Said; K Chien; Taizo Tasaka; H Phillip Koeffler
Ultrastructural characterization of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) in Kaposi's sarcoma lesions: electron microscopy permits distinction from cytomegalovirus (CMV).
The Journal of pathology 1997;182(3):273-81.
1997: Taizo Tasaka; S Lee; S Spira; S Takeuchi; M Nagai; J Takahara; H Phillip Koeffler
Microsatellite instability during the progression of acute myelocytic leukaemia.
British journal of haematology 1997;98(1):219-21.
1997: Seisho Takeuchi; Taku Seriu; Taizo Tasaka; M Koike; S K Cho; S Park; J Slater; I Mufti; Y Hatta; I Miyoshi; Claus R Bartram; H Phillip Koeffler
Microsatellite instability and other molecular abnormalities in childhood acute lymphoblastic leukaemia.
British journal of haematology 1997;98(1):134-9.
1997: Sven de Vos; M I Dawson; S Holden; T Le; A Wang; S K Cho; D L Chen; H Phillip Koeffler
Effects of retinoid X receptor-selective ligands on proliferation of prostate cancer cells.
The Prostate 1997;32(2):115-21.
1997: Y Hatta; Yasuaki Yamada; Masao Tomonaga; H Phillip Koeffler
Extensive analysis of the retinoblastoma gene in adult T cell leukemia/lymphoma (ATL).
Leukemia 1997;11(7):984-9.
1997: Masaaki Shiohara; K Koike; Atsushi Komiyama; H Phillip Koeffler
p21WAF1 mutations and human malignancies.
Leukemia & lymphoma 1997;26(1-2):35-41.
1997: Sven de Vos; S Holden; David Heber; Elena Elstner; Lise Binderup; Milan Uskokovic; B Rude; D L Chen; J Le; S K Cho; H Phillip Koeffler
Effects of potent vitamin D3 analogs on clonal proliferation of human prostate cancer cell lines.
The Prostate 1997;31(2):77-83.
1997: M Koike; Seisho Takeuchi; J Yokota; S Park; Y Hatta; Carl W Miller; N Tsuruoka; H Phillip Koeffler
Frequent loss of heterozygosity in the region of the D7S523 locus in advanced ovarian cancer.
Genes, chromosomes & cancer 1997;19(1):1-5.
1997: D J Park; S P Wilczynski; E Y Pham; Carl W Miller; H Phillip Koeffler
Molecular analysis of the INK4 family of genes in prostate carcinomas.
The Journal of urology 1997;157(5):1995-9.
1997: Carl W Miller; H Phillip Koeffler
Cyclin-dependent kinase inhibitors in human neoplasms.
Leukemia 1997;11 Suppl 3():370-1.
1997: Tsuyoshi Nakamaki; C Bartram; Taku Seriu; J Kahan; Kunihiko Fukuchi; N Tsuruoka; Johannes W G Janssen; Carl W Miller; H Phillip Koeffler
Molecular analysis of the cyclin-dependent kinase inhibitor genes, p15, p16, p18 and p19 in the myelodysplastic syndromes.
Leukemia research 1997;21(3):235-40.
1997: I Grillier; T Umiel; E Elstner; S J Collins; H Phillip Koeffler
Alterations of differentiation, clonal proliferation, cell cycle progression and bcl-2 expression in RAR alpha-altered sublines of HL-60.
Leukemia 1997;11(3):393-400.
1997: Taizo Tasaka; Jonathan W Said; Roberta Morosetti; D Park; W Verbeek; M Nagai; J Takahara; H Phillip Koeffler
Is Kaposi's sarcoma--associated herpesvirus ubiquitous in urogenital and prostate tissues?
Blood 1997;89(5):1686-9.
1997: Rong Yang; Roberta Morosetti; H Phillip Koeffler
Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines.
Cancer research 1997;57(5):913-20.
1997: Alexey Chumakov; I Grillier; E Chumakova; Doris Y Chih; J Slater; H Phillip Koeffler
Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor.
Molecular and cellular biology 1997;17(3):1375-86.
1997: M Wada; C W Miller; J Yokota; E Lee; H Mizoguchi; H Phillip Koeffler
Molecular analysis of the adenomatous polyposis coli gene in sarcomas, hematological malignancies and noncolonic, neoplastic tissues.
Journal of molecular medicine (Berlin, Germany) 1997;75(2):139-44.
1997: E Elstner; M Linker-Israeli; J Le; T Umiel; P Michl; J W Said; Lise Binderup; J C Reed; H Phillip Koeffler
Synergistic decrease of clonal proliferation, induction of differentiation, and apoptosis of acute promyelocytic leukemia cells after combined treatment with novel 20-epi vitamin D3 analogs and 9-cis retinoic acid.
The Journal of clinical investigation 1997;99(2):349-60.
1997: Y Hatta; Seisho Takeuchi; J Yokota; H Phillip Koeffler
Ovarian cancer has frequent loss of heterozygosity at chromosome 12p12.3-13.1 (region of TEL and Kip1 loci) and chromosome 12q23-ter: evidence for two new tumour-suppressor genes.
British journal of cancer 1997;75(9):1256-62.
1997: Norihiko Kawamata; Taku Seriu; Claus R Bartram; H Phillip Koeffler
Molecular analysis of the secretory phospholipase A2 gene, a candidate of Mom1 gene, in neuroblastomas.
Cancer letters 1997;111(1-2):71-5.
1997: Taizo Tasaka; James Berenson; Robert A Vescio; Toshiyasu Hirama; Carl W Miller; M Nagai; J Takahara; H Phillip Koeffler
Analysis of the p16INK4A, p15INK4B and p18INK4C genes in multiple myeloma.
British journal of haematology 1997;96(1):98-102.
1997: N Mori; S Takeuchi; Taizo Tasaka; S Lee; S Spira; D Ben-Yehuda; H Mizoguchi; G Schiller; H Phillip Koeffler
Absence of microsatellite instability during the progression of chronic myelocytic leukemia.
Leukemia 1997;11(1):151-2.
1996: Masaaki Shiohara; K Spirin; Jonathan W Said; Adrian F Gombart; Tsuyoshi Nakamaki; Seisho Takeuchi; Y Hatta; Roberta Morosetti; Taizo Tasaka; Taku Seriu; C Bartram; Carl W Miller; Masao Tomonaga; H Phillip Koeffler
Alterations of the cyclin-dependent kinase inhibitor p19 (INK4D) is rare in hematopoietic malignancies.
Leukemia 1996;10(12):1897-900.
1996: Jonathan W Said; Taizo Tasaka; Seisho Takeuchi; Hiroya Asou; Sven de Vos; E Cesarman; D M Knowles; H Phillip Koeffler
Primary effusion lymphoma in women: report of two cases of Kaposi's sarcoma herpes virus-associated effusion-based lymphoma in human immunodeficiency virus-negative women.
Blood 1996;88(8):3124-8.
1996: R Munker; T Kobayashi; Elena Elstner; A W Norman; M Uskokovic; W Zhang; M Andreeff; H Phillip Koeffler
A new series of vitamin D analogs is highly active for clonal inhibition, differentiation, and induction of WAF1 in myeloid leukemia.
Blood 1996;88(6):2201-9.
1996: N Kawamata; D Park; S Wilczynski; J Yokota; H Phillip Koeffler
Point mutations of the Mxil gene are rare in prostate cancers.
The Prostate 1996;29(3):191-3.
1996: Elena Elstner; M Linker-Israeli; T Umiel; J Le; I Grillier; Jonathan Said; I Peter Shintaku; S Krajewski; J C Reed; Lise Binderup; H Phillip Koeffler
Combination of a potent 20-epi-vitamin D3 analogue (KH 1060) with 9-cis-retinoic acid irreversibly inhibits clonal growth, decreases bcl-2 expression, and induces apoptosis in HL-60 leukemic cells.
Cancer research 1996;56(15):3570-6.
1996: Dorothy J Park; H Phillip Koeffler
Therapy-related myelodysplastic syndromes.
Seminars in hematology 1996;33(3):256-73.
1996: Roberta Morosetti; H Phillip Koeffler
Differentiation therapy in myelodysplastic syndromes.
Seminars in hematology 1996;33(3):236-45.
1996: A Ishiguro; K S Spirin; Masaaki Shiohara; A Tobler; Adrian F Gombart; Mark Israel; J D Norton; H Phillip Koeffler
Id2 expression increases with differentiation of human myeloid cells.
Blood 1996;87(12):5225-31.
1996: W Said; K Chien; Seisho Takeuchi; Taizo Tasaka; Hiroya Asou; S K Cho; Sven de Vos; E Cesarman; D M Knowles; H Phillip Koeffler
Kaposi's sarcoma-associated herpesvirus (KSHV or HHV8) in primary effusion lymphoma: ultrastructural demonstration of herpesvirus in lymphoma cells.
Blood 1996;87(12):4937-43.
1996: Dorothy J Park; Alexey Chumakov; Carl W Miller; E Y Pham; H Phillip Koeffler
p53 transactivation through various p53-responsive elements.
Molecular carcinogenesis 1996;16(2):101-8.
1996: Roberta Morosetti; F Grignani; C Liberatore; P G Pelicci; G J Schiller; Masahiro Kizaki; Claus R Bartram; Carl W Miller; H Phillip Koeffler
Infrequent alterations of the RAR alpha gene in acute myelogenous leukemias, retinoic acid-resistant acute promyelocytic leukemias, myelodysplastic syndromes, and cell lines.
Blood 1996;87(10):4399-403.
1996: K S Spirin; J F Simpson; Seisho Takeuchi; N Kawamata; Carl W Miller; H Phillip Koeffler
p27/Kip1 mutation found in breast cancer.
Cancer research 1996;56(10):2400-4.
1996: Theodore B Moore; H Phillip Koeffler; Joyce Yamashiro; R K Wada
Vitamin D3 analogs inhibit growth and induce differentiation in LA-N-5 human neuroblastoma cells.
Clinical & experimental metastasis 1996;14(3):239-45.
1996: Seisho Takeuchi; Claus R Bartram; Carl W Miller; A Reiter; Taku Seriu; M Zimmerann; Martin Schrappe; N Mori; J Slater; I Miyoshi; H Phillip Koeffler
Acute lymphoblastic leukemia of childhood: identification of two distinct regions of deletion on the short arm of chromosome 12 in the region of TEL and KIP1.
Blood 1996;87(8):3368-74.
1996: H Phillip Koeffler
Myelodysplastic syndromes.
Seminars in hematology 1996;33(2):87-94.
1996: N Kawamata; C Miller; V Levy; I Peter Shintaku; H Phillip Koeffler; J W Said
mdm-2 oncogene expression in non-Hodgkin's lymphomas.
Diagnostic molecular pathology : the American journal of surgical pathology, part B 1996;5(1):33-8.
1996: V Levy; C Miller; H Phillip Koeffler; Jonathan W Said
p53 in lymphomas of mucosal-associated lymphoid tissues.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1996;9(3):245-8.
1996: Masahiro Kizaki; Marcia I Dawson; R Heyman; E Elster; Roberta Morosetti; Seppo Pakkala; D L Chen; H Ueno; W Chao; M Morikawa; Yasuo Ikeda; D Heber; M Pfahl; H Phillip Koeffler
Effects of novel retinoid X receptor-selective ligands on myeloid leukemia differentiation and proliferation in vitro.
Blood 1996;87(5):1977-84.
1996: Masaaki Shiohara; M Akashi; Adrian F Gombart; Rong Yang; H Phillip Koeffler
Tumor necrosis factor alpha: posttranscriptional stabilization of WAF1 mRNA in p53-deficient human leukemic cells.
Journal of cellular physiology 1996;166(3):568-76.
1996: Seisho Takeuchi; N Mori; M Koike; J Slater; S Park; Carl W Miller; I Miyoshi; H Phillip Koeffler
Frequent loss of heterozygosity in region of the KIP1 locus in non-small cell lung cancer: evidence for a new tumor suppressor gene on the short arm of chromosome 12.
Cancer research 1996;56(4):738-40.
1996: N Kawamata; Taku Seriu; H Phillip Koeffler; Claus R Bartram
Molecular analysis of the cyclin-dependent kinase inhibitor family: p16(CDKN2/MTS1/INK4A), p18(INK4C) and p27(Kip1) genes in neuroblastomas.
Cancer 1996;77(3):570-5.
1996: T Tasak; S Lee; S Spira; S Takeuchi; Y Hatta; M Nagai; J Takahara; H Phillip Koeffler
Infrequent microsatellite instability during the evolution of myelodysplastic syndrome to acute myelocytic leukemia.
Leukemia research 1996;20(2):113-7.
1996: Carl W Miller; A Aslo; M J Campbell; N Kawamata; B C Lampkin; H Phillip Koeffler
Alterations of the p15, p16,and p18 genes in osteosarcoma.
Cancer genetics and cytogenetics 1996;86(2):136-42.
1996: Masahiro Kizaki; H Ueno; Y Yamazoe; M Shimada; Nobuyuki Takayama; A Muto; Hiromichi Matsushita; H Nakajima; M Morikawa; H Phillip Koeffler; Yasuo Ikeda
Mechanisms of retinoid resistance in leukemic cells: possible role of cytochrome P450 and P-glycoprotein.
Blood 1996;87(2):725-33.
1996: Rong Yang; M Serrano; J Slater; E Leung; H Phillip Koeffler
Analysis of p16INK4a and its interaction with CDK4.
Biochemical and biophysical research communications 1996;218(1):254-9.
1996: T Hirama; Carl W Miller; S P Wilczynski; H Phillip Koeffler
p16 (CDKN2/cyclin-dependent kinase-4 inhibitor/multiple tumor suppressor-1) gene is not altered in uterine cervical carcinomas or cell lines.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1996;9(1):26-31.
1995: A Ishiguro; K Spirin; Masaaki Shiohara; A Tobler; J D Norton; M Rigolet; T Shimbo; H Phillip Koeffler
Expression of Id2 and Id3 mRNA in human lymphocytes.
Leukemia research 1995;19(12):989-96.
1995: N Kawamata; Carl W Miller; H Phillip Koeffler
Molecular analysis of a family of cyclin-dependent kinase inhibitor genes (p15/MTS2/INK4b and p18/INK4c) in non-small cell lung cancers.
Molecular carcinogenesis 1995;14(4):263-8.
1995: Tsuyoshi Nakamaki; J Imamura; G Brewer; N Tsuruoka; H Phillip Koeffler
Characterization of adenosine-uridine-rich RNA binding factors.
Journal of cellular physiology 1995;165(3):484-92.
1995: Seisho Takeuchi; Claus R Bartram; M Wada; A Reiter; Y Hatta; Taku Seriu; E Lee; Carl W Miller; I Miyoshi; H Phillip Koeffler
Allelotype analysis of childhood acute lymphoblastic leukemia.
Cancer research 1995;55(22):5377-82.
1995: Sven de Vos; Carl W Miller; Seisho Takeuchi; A F Gombart; S K Cho; H Phillip Koeffler
Alterations of CDKN2 (p16) in non-small cell lung cancer.
Genes, chromosomes & cancer 1995;14(3):164-70.
1995: Y Hatta; T Hirama; S Takeuchi; E Lee; E Pham; Carl W Miller; T Strohmeyer; S P Wilczynski; S Melmed; H Phillip Koeffler
Alterations of the p16 (MTS1) gene in testicular, ovarian, and endometrial malignancies.
The Journal of urology 1995;154(5):1954-7.
1995: R Morosétti; N Kawamata; Adrian F Gombart; Carl W Miller; Y Hatta; T Hirama; Jonathan W Said; Masao Tomonaga; H Phillip Koeffler
Alterations of the p27KIP1 gene in non-Hodgkin's lymphomas and adult T-cell leukemia/lymphoma.
Blood 1995;86(5):1924-30.
1995: Adrian F Gombart; Roberta Morosetti; Carl W Miller; Jonathan W Said; H Phillip Koeffler
Deletions of the cyclin-dependent kinase inhibitor genes p16INK4A and p15INK4B in non-Hodgkin's lymphomas.
Blood 1995;86(4):1534-9.
1995: T Hirama; H Phillip Koeffler
Role of the cyclin-dependent kinase inhibitors in the development of cancer.
Blood 1995;86(3):841-54.
1995: M Wada; Robert C Seeger; H Mizoguchi; H Phillip Koeffler
Maintenance of normal imprinting of H19 and IGF2 genes in neuroblastoma.
Cancer research 1995;55(15):3386-8.
1995: Elena Elstner; M Linker-Israeli; Jonathan Said; T Umiel; Sven de Vos; I Peter Shintaku; David Heber; Lise Binderup; M Uskokovic; H Phillip Koeffler
20-epi-vitamin D3 analogues: a novel class of potent inhibitors of proliferation and inducers of differentiation of human breast cancer cell lines.
Cancer research 1995;55(13):2822-30.
1995: Rong Yang; Adrian F Gombart; M Serrano; H Phillip Koeffler
Mutational effects on the p16INK4a tumor suppressor protein.
Cancer research 1995;55(12):2503-6.
1995: S Takeuchi; C R Bartram; R Ludwig; Brigitte Royer-Pokora; S Schneider; J Imamura; H Phillip Koeffler
Mutations of p53 in Wilms' tumors.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1995;8(5):483-7.
1995: Y Hatta; T Hirama; Carl W Miller; Yasuaki Yamada; Masao Tomonaga; H Phillip Koeffler
Homozygous deletions of the p15 (MTS2) and p16 (CDKN2/MTS1) genes in adult T-cell leukemia.
Blood 1995;85(10):2699-704.
1995: M Fleischhacker; S Lee; S Spira; S Takeuchi; H Phillip Koeffler
DNA aneuploidy in morphologically normal colons from patients with colon cancer.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1995;8(4):360-5.
1995: Sven de Vos; C J Epstein; E Carlson; S K Cho; H Phillip Koeffler
Transgenic mice overexpressing human copper/zinc-superoxide dismutase (Cu/Zn SOD) are not resistant to endotoxic shock.
Biochemical and biophysical research communications 1995;208(2):523-31.
1995: Y Imai; J W Pike; H Phillip Koeffler
Potent vitamin D3 analogs: their abilities to enhance transactivation and to bind to the vitamin D3 response element.
Leukemia research 1995;19(3):147-58.
1995: Seppo Pakkala; Sven de Vos; Elena Elstner; R K Rude; M Uskokovic; Lise Binderup; H Phillip Koeffler
Vitamin D3 analogs: effect on leukemic clonal growth and differentiation, and on serum calcium levels.
Leukemia research 1995;19(1):65-72.
1994: Masaaki Shiohara; Wafik S El-Deiry; M Wada; Tsuyoshi Nakamaki; Seisho Takeuchi; Rong Yang; D L Chen; Bert Vogelstein; H Phillip Koeffler
Absence of WAF1 mutations in a variety of human malignancies.
Blood 1994;84(11):3781-4.
1994: Elena Elstner; Young Yiul Lee; M Hashiya; Seppo Pakkala; Lise Binderup; A W Norman; W H Okamura; H Phillip Koeffler
1 alpha,25-Dihydroxy-20-epi-vitamin D3: an extraordinarily potent inhibitor of leukemic cell growth in vitro.
Blood 1994;84(6):1960-7.
1994: M Hachiya; Alexey Chumakov; Carl W Miller; M Akashi; Jonathan Said; H Phillip Koeffler
Mutant p53 proteins behave in a dominant, negative fashion in vivo.
Anticancer research 1994;14(5A):1853-9.
1994: Y Imai; T G Strohmeyer; M Fleischhacker; Dennis J Slamon; H Phillip Koeffler
p53 mutations and MDM-2 amplification in renal cell cancers.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1994;7(7):766-70.
1994: Akiko Sakashita; J T Curnutte; H Phillip Koeffler
Myeloid haemopoietic cells of patients with chronic granulomatous disease are relatively resistant to TNF.
British journal of haematology 1994;88(1):31-8.
1994: Akiko Sakashita; C J Epstein; E Carlson; H Phillip Koeffler
Hematopoietic progenitor cells of transgenic mice with increased copper/zinc-superoxide dismutase activity are resistant to tumor necrosis factor.
Journal of cellular physiology 1994;160(2):233-8.
1994: Marcia I Dawson; Elena Elstner; Masahiro Kizaki; D L Chen; Seppo Pakkala; B Kerner; H Phillip Koeffler
Myeloid differentiation mediated through retinoic acid receptor/retinoic X receptor (RXR) not RXR/RXR pathway.
Blood 1994;84(2):446-52.
1994: Francis Giles; H Phillip Koeffler
Secondary myelodysplastic syndromes and leukemias.
Current opinion in hematology 1994;1(4):256-60.
1994: Dorothy J Park; H Nakamura; Alexey Chumakov; J W Said; Carl W Miller; D L Chen; H Phillip Koeffler
Transactivational and DNA binding abilities of endogenous p53 in p53 mutant cell lines.
Oncogene 1994;9(7):1899-906.
1994: S J Jung; Young Yiul Lee; Seppo Pakkala; Sven de Vos; Elena Elstner; A W Norman; J Green; M Uskokovic; H Phillip Koeffler
1,25(OH)2-16ene-vitamin D3 is a potent antileukemic agent with low potential to cause hypercalcemia.
Leukemia research 1994;18(6):453-63.
1994: Masahiro Kizaki; H Nakajima; S Mori; T Koike; M Morikawa; M Ohta; M Saito; H Phillip Koeffler; Yasuo Ikeda
Novel retinoic acid, 9-cis retinoic acid, in combination with all-trans retinoic acid is an effective inducer of differentiation of retinoic acid-resistant HL-60 cells.
Blood 1994;83(11):3289-97.
1994: Y Y Lee; S P Wilczynski; Alexey Chumakov; Doris Y Chih; H Phillip Koeffler
Carcinoma of the vulva: HPV and p53 mutations.
Oncogene 1994;9(6):1655-9.
1994: A E Walts; Jonathan W Said; H Phillip Koeffler
Is immunoreactivity for p53 useful in distinguishing benign from malignant effusions? Localization of p53 gene product in benign mesothelial and adenocarcinoma cells.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1994;7(4):462-8.
1994: M Fleischhacker; T Strohmeyer; Y Imai; Dennis J Slamon; H Phillip Koeffler
Mutations of the p53 gene are not detectable in human testicular tumors.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1994;7(4):435-9.
1994: M Kizaki; Carl W Miller; Michael Selsted; H Phillip Koeffler
Myeloperoxidase (MPO) gene mutation in hereditary MPO deficiency.
Blood 1994;83(7):1935-40.
1994: Dorothy J Park; S P Wilczynski; Ronald L Paquette; Carl W Miller; H Phillip Koeffler
p53 mutations in HPV-negative cervical carcinoma.
Oncogene 1994;9(1):205-10.
1993: Masahiro Kizaki; Yasuo Ikeda; R Tanosaki; H Nakajima; M Morikawa; A Sakashita; H Phillip Koeffler
Effects of novel retinoic acid compound, 9-cis-retinoic acid, on proliferation, differentiation, and expression of retinoic acid receptor-alpha and retinoid X receptor-alpha RNA by HL-60 cells.
Blood 1993;82(12):3592-9.
1993: Alexey Chumakov; Carl W Miller; D L Chen; H Phillip Koeffler
Analysis of p53 transactivation through high-affinity binding sites.
Oncogene 1993;8(11):3005-11.
1993: A E Walts; H Phillip Koeffler; Jonathan W Said
Localization of p53 protein and human papillomavirus in anogenital squamous lesions: immunohistochemical and in situ hybridization studies in benign, dysplastic, and malignant epithelia.
Human pathology 1993;24(11):1238-42.
1993: Masahiro Kizaki; Y Ikeda; K J Simon; M Nanjo; H Phillip Koeffler
Effect of 1,25-dihydroxyvitamin D3 and its analogs on human immunodeficiency virus infection in monocytes/macrophages.
Leukemia 1993;7(10):1525-30.
1993: Michael Selsted; C W Miller; M J Novotny; W L Morris; H Phillip Koeffler
Molecular analysis of myeloperoxidase deficiency shows heterogeneous patterns of the complete deficiency state manifested at the genomic, mRNA, and protein levels.
Blood 1993;82(4):1317-22.
1993: Ronald L Paquette; Y Y Lee; S P Wilczynski; A Karmakar; Masahiro Kizaki; Carl W Miller; H Phillip Koeffler
Mutations of p53 and human papillomavirus infection in cervical carcinoma.
Cancer 1993;72(4):1272-80.
1993: Masahiro Kizaki; A Sakashita; A Karmakar; C W Lin; H Phillip Koeffler
Regulation of manganese superoxide dismutase and other antioxidant genes in normal and leukemic hematopoietic cells and their relationship to cytotoxicity by tumor necrosis factor.
Blood 1993;82(4):1142-50.
1993: C Miller; H Phillip Koeffler
P53 mutations in human cancer.
Leukemia 1993;7 Suppl 2():S18-21.
1993: H Nakamura; Jonathan W Said; Carl W Miller; H Phillip Koeffler
Mutation and protein expression of p53 in acquired immunodeficiency syndrome-related lymphomas.
Blood 1993;82(3):920-6.
1993: Ronald L Paquette; Elliot M Landaw; R V Pierre; J Kahan; Michael Lübbert; O Lazcano; G Isaac; F McCormick; H Phillip Koeffler
N-ras mutations are associated with poor prognosis and increased risk of leukemia in myelodysplastic syndrome.
Blood 1993;82(2):590-9.
1993: Carl W Miller; Alexey Chumakov; Jonathan Said; D L Chen; A Aslo; H Phillip Koeffler
Mutant p53 proteins have diverse intracellular abilities to oligomerize and activate transcription.
Oncogene 1993;8(7):1815-24.
1993: Alexey Chumakov; D L Chen; E A Chumakova; H Phillip Koeffler
Localization of the c-ets-2 transactivation domain.
Journal of virology 1993;67(4):2421-5.
1993: A Sakashita; Masahiro Kizaki; Seppo Pakkala; G Schiller; N Tsuruoka; R Tomosaki; J F Cameron; Marcia I Dawson; H Phillip Koeffler
9-cis-retinoic acid: effects on normal and leukemic hematopoiesis in vitro.
Blood 1993;81(4):1009-16.
1993: James A Fagin; K Matsuo; A Karmakar; D L Chen; S H Tang; H Phillip Koeffler
High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas.
The Journal of clinical investigation 1993;91(1):179-84.
1992: Y Y Lee; Ira Kurtz; K Yamato; Z el-Hajjoui; H Phillip Koeffler
Tumor necrosis factor stimulates Na+/H+ antiporter in human fibroblasts: dissociation between intracellular alkalinization and cytokine mRNA accumulation.
Blood 1992;79(9):2262-6.
1992: Carl W Miller; K Simon; A Aslo; K Kok; J Yokota; C H Buys; M Terada; H Phillip Koeffler
p53 mutations in human lung tumors.
Cancer research 1992;52(7):1695-8.
1992: Masahiro Kizaki; H Phillip Koeffler
Differentiation-inducing agents in the treatment of myelodysplastic syndromes.
Seminars in oncology 1992;19(1):95-105.
1992: A Sakashita; T Hattori; Carl W Miller; H Suzushima; N Asou; K Takatsuki; H Phillip Koeffler
Mutations of the p53 gene in adult T-cell leukemia.
Blood 1992;79(2):477-80.
1991: M Akashi; G Shaw; M Gross; M Saito; H Phillip Koeffler
Role of AUUU sequences in stabilization of granulocyte-macrophage colony-stimulating factor RNA in stimulated cells.
Blood 1991;78(8):2005-12.
1991: B Figadère; Anthony W Norman; Helen L Henry; H Phillip Koeffler; J Y Zhou; William H Okamura
Arocalciferols: synthesis and biological evaluation of aromatic side-chain analogues of 1 alpha,25-dihydroxyvitamin D3(1a).
Journal of medicinal chemistry 1991;34(8):2452-63.
1991: Michael Lübbert; W Salser; M Prokocimer; Carl W Miller; A Thomason; H Phillip Koeffler
Stable methylation patterns of MYC and other genes regulated during terminal myeloid differentiation.
Leukemia 1991;5(7):533-9.
1991: J Y Zhou; Anthony W Norman; M Akashi; D L Chen; M R Uskokovic; J M Aurrecoechea; W G Dauben; William H Okamura; H Phillip Koeffler
Development of a novel 1,25(OH)2-vitamin D3 analog with potent ability to induce HL-60 cell differentiation without modulating calcium metabolism.
Blood 1991;78(1):75-82.
1991: H J Ross; N Sato; Y Ueyama; H Phillip Koeffler
Cytokine messenger RNA stability is enhanced in tumor cells.
Blood 1991;77(8):1787-95.
1991: Masahiro Kizaki; Anthony W Norman; J E Bishop; C W Lin; A Karmakar; H Phillip Koeffler
1,25-Dihydroxyvitamin D3 receptor RNA: expression in hematopoietic cells.
Blood 1991;77(6):1238-47.
1991: H Reichel; June E Bishop; H Phillip Koeffler; Anthony W Norman
Evidence for 1,25-dihydroxyvitamin D3 production by cultured porcine alveolar macrophages.
Molecular and cellular endocrinology 1991;75(2):163-7.
1991: K Yamato; Z el-Hajjoui; H Phillip Koeffler
Expression of hematopoietic growth factor RNAs in human mesenchymal cells from various organs.
Leukemia research 1991;15(7):551-8.
1991: T Miyagi; M Akashi; K Yamato; I Miyoshi; H Phillip Koeffler
D-factor: modulation of expression in fibroblasts.
Leukemia research 1991;15(6):441-51.
1990: Carl W Miller; A Aslo; C Tsay; Dennis J Slamon; K Ishizaki; J Toguchida; T Yamamuro; B Lampkin; H Phillip Koeffler
Frequency and structure of p53 rearrangements in human osteosarcoma.
Cancer research 1990;50(24):7950-4.
1990: Robert W O'rourke; Carl W Miller; Gregory Kato ; K J Simon; D L Chen; Chi Dang; H Phillip Koeffler
A potential transcriptional activation element in the p53 protein.
Oncogene 1990;5(12):1829-32.
1990: Ronald L Paquette; J Berenson; Alan Lichtenstein; F McCormick; H Phillip Koeffler
Oncogenes in multiple myeloma: point mutation of N-ras.
Oncogene 1990;5(11):1659-63.
1990: Anthony W Norman; J Y Zhou; Helen L Henry; M R Uskokovic; H Phillip Koeffler
Structure-function studies on analogues of 1 alpha,25-dihydroxyvitamin D3: differential effects on leukemic cell growth, differentiation, and intestinal calcium absorption.
Cancer research 1990;50(21):6857-64.
1990: K Yamato; Z el-Hajjaoui; K Simon; H Phillip Koeffler
Modulation of interleukin-1 beta RNA in monocytic cells infected with human immunodeficiency virus-1.
The Journal of clinical investigation 1990;86(4):1109-14.
1990: J Y Zhou; Anthony W Norman; D L Chen; G W Sun; M Uskokovic; H Phillip Koeffler
1,25-Dihydroxy-16-ene-23-yne-vitamin D3 prolongs survival time of leukemic mice.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(10):3929-32.
1990: G X Sun; H Phillip Koeffler; Robert Peter Gale; RS Sparkes; R R Schreck
Use of conditioned media in cell culture can mask cytogenetic abnormalities in acute leukemia.
Cancer genetics and cytogenetics 1990;46(1):107-13.
1990: J Y Zhou; D L Chen; Z S Shen; H Phillip Koeffler
Effect of homoharringtonine on proliferation and differentiation of human leukemic cells in vitro.
Cancer research 1990;50(7):2031-5.
1990: Michael Lübbert; D Jonas; Carl W Miller; F Herrmann; R Mertelsmann; F McCormick; H Phillip Koeffler
Retrospective analysis of ras gene activation in myeloid leukemic cells.
Oncogene 1990;5(4):583-7.
1990: H Phillip Koeffler; June E Bishop; H Reichel; F Singer; A Nagler; A Tobler; M Walka; Anthony W Norman
Lymphocyte cell lines from vitamin D-dependent rickets type II show functional defects in the 1 alpha,25-dihydroxyvitamin D3 receptor.
Molecular and cellular endocrinology 1990;70(1):1-11.
1990: Michael Lübbert; J Mirro; Carl W Miller; J Kahan; G Isaac; G Kitchingman; R Mertelsmann; F Herrmann; F McCormick; H Phillip Koeffler
N-ras gene point mutations in childhood acute lymphocytic leukemia correlate with a poor prognosis.
Blood 1990;75(5):1163-9.
1990: M Akashi; H Phillip Koeffler
Control of hematopoietic growth factors.
Progress in clinical and biological research 1990;352():257-67.
1990: H Reichel; H Phillip Koeffler; A W Norman
Production of 1 alpha,25-dihydroxyvitamin D3 by hematopoietic cells.
Progress in clinical and biological research 1990;332():81-97.
1990: Masahiro Kizaki; H Phillip Koeffler; C W Lin; Carl W Miller
Expression of retinoic acid receptor mRNA in hematopoietic cells.
Leukemia research 1990;14(7):645-55.
1990: M Akashi; A H Loussararian; Daniel C Adelman; M Saito; H Phillip Koeffler
Role of lymphotoxin in expression of interleukin 6 in human fibroblasts. Stimulation and regulation.
The Journal of clinical investigation 1990;85(1):121-9.
1989: M Akashi; M Saito; H Phillip Koeffler
Lymphotoxin: stimulation and regulation of colony-stimulating factors in fibroblasts.
Blood 1989;74(7):2383-90.
1989: Stephen D Nimer; M J Gates; H Phillip Koeffler; Judith C Gasson
Multiple mechanisms control the expression of granulocyte-macrophage colony-stimulating factor by human fibroblasts.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(7):2374-7.
1989: K Yamato; Z El-Hajjaoui; J F Kuo; H Phillip Koeffler
Granulocyte-macrophage colony-stimulating factor: signals for its mRNA accumulation.
Blood 1989;74(4):1314-20.
1989: J Y Zhou; Anthony W Norman; Michael Lübbert; E D Collins; M R Uskokovic; H Phillip Koeffler
Novel vitamin D analogs that modulate leukemic cell growth and differentiation with little effect on either intestinal calcium absorption or bone mobilization.
Blood 1989;74(1):82-93.
1989: K Yamato; Z el-Hajjaoui; H Phillip Koeffler
Regulation of levels of IL-1 mRNA in human fibroblasts.
Journal of cellular physiology 1989;139(3):610-6.
1989: A Tobler; Michael Selsted; Carl W Miller; K R Johnson; M J Novotny; G Rovera; H Phillip Koeffler
Evidence for a pretranslational defect in hereditary and acquired myeloperoxidase deficiency.
Blood 1989;73(7):1980-6.
1989: Michael Lübbert; Carl W Miller; J Kahan; H Phillip Koeffler
Expression, methylation and chromatin structure of the p53 gene in untransformed and human T-cell leukemia virus type I-transformed human T-lymphocytes.
Oncogene 1989;4(5):643-51.
1988: A Tobler; C W Miller; K R Johnson; Michael Selsted; G Rovera; H Phillip Koeffler
Regulation of gene expression of myeloperoxidase during myeloid differentiation.
Journal of cellular physiology 1988;136(2):215-25.
1988: H Phillip Koeffler; Judith C Gasson; A Tobler
Transcriptional and posttranscriptional modulation of myeloid colony-stimulating factor expression by tumor necrosis factor and other agents.
Molecular and cellular biology 1988;8(8):3432-8.
1988: A Tobler; C W Miller; Anthony W Norman; H Phillip Koeffler
1,25-Dihydroxyvitamin D3 modulates the expression of a lymphokine (granulocyte-macrophage colony-stimulating factor) posttranscriptionally.
The Journal of clinical investigation 1988;81(6):1819-23.
1988: Ronald L Paquette; J Y Zhou; Y C Yang; S C Clark; H Phillip Koeffler
Recombinant gibbon interleukin-3 acts synergistically with recombinant human G-CSF and GM-CSF in vitro.
Blood 1988;71(6):1596-600.
1988: N Sidell; H Phillip Koeffler
Modulation of Mr 53,000 protein with induction of differentiation of human neuroblastoma cells.
Cancer research 1988;48(8):2226-30.
1988: Michael Lübbert; C W Miller; L Crawford; H Phillip Koeffler
p53 in chronic myelogenous leukemia. Study of mechanisms of differential expression.
The Journal of experimental medicine 1988;167(3):873-86.
1988: H Phillip Koeffler; D Heitjan; R Mertelsmann; J E Kolitz; Philip Schulman; L Itri; P Gunter; E Besa
Randomized study of 13-cis retinoic acid v placebo in the myelodysplastic disorders.
Blood 1988;71(3):703-8.
1987: A Tobler; R Munker; D Heitjan; H Phillip Koeffler
In vitro interaction of recombinant tumor necrosis factor alpha and all-trans-retinoic acid with normal and leukemic hematopoietic cells.
Blood 1987;70(6):1940-6.
1987: R Munker; J DiPersio; H Phillip Koeffler
Tumor necrosis factor: receptors on hematopoietic cells.
Blood 1987;70(6):1730-4.
1987: H Masuda; C Miller; H Phillip Koeffler; H Battifora; M J Cline
Rearrangement of the p53 gene in human osteogenic sarcomas.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(21):7716-9.
1987: A Tobler; H Phillip Koeffler
Differentiation of human acute myelogenous leukemia cells: therapeutic possibilities.
Acta haematologica 1987;78 Suppl 1():127-35.