Andrew Koff

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Liu Yan; Elf Shannon E; Asai Takashi; Miyata Yasuhiko; Liu Yuhui; Sashida Goro; Huang Gang; Di Giandomenico Silvana; Koff Andrew; Nimer Stephen D
The p53 tumor suppressor protein is a critical regulator of hematopoietic stem cell behavior.
Liu Liren; Lee Sharrell; Zhang Jianxuan; Peters Sara B; Hannah Jeffrey; Zhang Yue; Yin Yan; Koff Andrew; Ma Liang; Zhou Pengbo
CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis.
Liu Yan; Elf Shannon E; Miyata Yasuhiko; Sashida Goro; Liu Yuhui; Huang Gang; Di Giandomenico Silvana; Lee Jennifer M; Deblasio Anthony; Menendez Silvia; Antipin Jack; Reva Boris; Koff Andrew; Nimer Stephen D
p53 regulates hematopoietic stem cell quiescence.

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2009: Liu Yan; Elf Shannon E; Asai Takashi; Miyata Yasuhiko; Liu Yuhui; Sashida Goro; Huang Gang; Di Giandomenico Silvana; Koff Andrew; Nimer Stephen D
The p53 tumor suppressor protein is a critical regulator of hematopoietic stem cell behavior.
Cell cycle (Georgetown, Tex.) 2009;8(19):3120-4.
2009: Liu Liren; Lee Sharrell; Zhang Jianxuan; Peters Sara B; Hannah Jeffrey; Zhang Yue; Yin Yan; Koff Andrew; Ma Liang; Zhou Pengbo
CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis.
Molecular cell 2009;34(4):451-60.
2009: Liu Yan; Elf Shannon E; Miyata Yasuhiko; Sashida Goro; Liu Yuhui; Huang Gang; Di Giandomenico Silvana; Lee Jennifer M; Deblasio Anthony; Menendez Silvia; Antipin Jack; Reva Boris; Koff Andrew; Nimer Stephen D
p53 regulates hematopoietic stem cell quiescence.
Cell stem cell 2009;4(1):37-48.
2007: Miller Jeffrey P; Yeh Nancy; Vidal Anxo; Koff Andrew
Interweaving the cell cycle machinery with cell differentiation.
Cell cycle (Georgetown, Tex.) 2007;6(23):2932-8.
2007: Liu Yuhui; Yeh Nancy; Zhu Xin-Hua; Leversha Margaret; Cordon-Cardo Carlos; Ghossein Ronald; Singh Bhuvanesh; Holland Eric; Koff Andrew
Somatic cell type specific gene transfer reveals a tumor-promoting function for p21(Waf1/Cip1).
The EMBO journal 2007;26(22):4683-93.
2007: Smartt Helena J M; Guilmeau Sandra; Nasser Shannon V; Nicholas Courtney; Bancroft Laura; Simpson Sharon A; Yeh Nancy; Yang Wancai; Mariadason John M; Koff Andrew; Augenlicht Leonard H
p27kip1 Regulates cdk2 activity in the proliferating zone of the mouse intestinal epithelium: potential role in neoplasia.
Gastroenterology 2007;133(1):232-43.
2007: Yeh Nancy; Miller Jeffrey P; Gaur Tripti; Capellini Terence D; Nikolich-Zugich Janko; de la Hoz Carmen; Selleri Licia; Bromage Timothy G; van Wijnen Andre J; Stein Gary S; Lian Jane B; Vidal Anxo; Koff Andrew
Cooperation between p27 and p107 during endochondral ossification suggests a genetic pathway controlled by p27 and p130.
Molecular and cellular biology 2007;27(14):5161-71.
2006: Hulit James; Lee Richard J; Li Zhiping; Wang Chenguang; Katiyar Sanjay; Yang Jianguo; Quong Andrew A; Wu Kongming; Albanese Chris; Russell Robert; Di Vizio Dolores; Koff Andrew; Thummala Saiinder; Zhang Hui; Harrell Jennifer; Sun Hong; Muller William J; Inghirami Giorgio; Lisanti Michael P; Pestell Richard G
p27Kip1 repression of ErbB2-induced mammary tumor growth in transgenic mice involves Skp2 and Wnt/beta-catenin signaling.
Cancer research 2006;66(17):8529-41.
2006: Refik-Rogers Jale; Manova Katia; Koff Andrew
Misexpression of cyclin B3 leads to aberrant spermatogenesis.
Cell cycle (Georgetown, Tex.) 2006;5(17):1966-73.
2006: Guidi Cynthia J; Mudhasani Rajini; Hoover Kathleen; Koff Andrew; Leav Irwin; Imbalzano Anthony N; Jones Stephen N
Functional interaction of the retinoblastoma and Ini1/Snf5 tumor suppressors in cell growth and pituitary tumorigenesis.
Cancer research 2006;66(16):8076-82.
2006: Liu Yan; Hedvat Cyrus V; Mao Shifeng; Zhu Xin-Hua; Yao Jinjuan; Nguyen Hoang; Koff Andrew; Nimer Stephen D
The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2.
Molecular and cellular biology 2006;26(8):3114-23.
2006: Koff Andrew
How to decrease p27Kip1 levels during tumor development.
Cancer cell 2006;9(2):75-6.
2005: Kuzushita Noriyoshi; Rogers Arlin B; Monti Nola A; Whary Mark T; Park Min J; Aswad Bassam I; Shirin Haim; Koff Andrew; Eguchi Hidetoshi; Moss Steven F
p27kip1 deficiency confers susceptibility to gastric carcinogenesis in Helicobacter pylori-infected mice.
Gastroenterology 2005;129(5):1544-56.
2005: Feng Zheng; Plati Anna Rita; Cheng Qing-li; Berho Mariana; Banerjee Anita; Potier Mylene; Jy Wen-che; Koff Andrew; Striker Liliane J; Striker Gary E
Glomerular aging in females is a multi-stage reversible process mediated by phenotypic changes in progenitors.
The American journal of pathology 2005;167(2):355-63.
2005: Sakakibara Kenji; Kubota Kenji; Worku Berhane; Ryer Evan J; Miller Jeffrey P; Koff Andrew; Kent K Craig; Liu Bo
PDGF-BB regulates p27 expression through ERK-dependent RNA turn-over in vascular smooth muscle cells.
The Journal of biological chemistry 2005;280(27):25470-7.
2005: Vidal Anxo; Zacharoulis Stergios; Guo Wenjun; Shaffer David; Giancotti Filippo; Bramley Anna H; de la Hoz Carmen; Jensen Kristian K; Kato Daniel; MacDonald Daniel D; Knowles Joseph; Yeh Nancy; Frohman Lawrence A; Rafii Shahin; Lyden David; Koff Andrew
p130Rb2 and p27kip1 cooperate to control mobilization of angiogenic progenitors from the bone marrow.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(19):6890-5.
2005: Shaffer David R; Viale Agnes; Ishiwata Ryota; Leversha Margaret; Olgac Semra; Manova Katia; Satagopan Jaya; Scher Howard; Koff Andrew
Evidence for a p27 tumor suppressive function independent of its role regulating cell proliferation in the prostate.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(1):210-5.
2004: Zhu Xin-Hua; Nguyen Hoang; Halicka H Dorota; Traganos Frank; Koff Andrew
Noncatalytic requirement for cyclin A-cdk2 in p27 turnover.
Molecular and cellular biology 2004;24(13):6058-66.
2003: Blain Stacy W; Scher Howard I; Cordon-Cardo Carlos; Koff Andrew
p27 as a target for cancer therapeutics.
Cancer cell 2003;3(2):111-5.
2003: Carneiro Carmen; Jiao Maria Socorro; Hu Ming; Shaffer David; Park Michele; Pandolfi Pier Paolo; Cordon-Cardo Carlos; Koff Andrew
p27 deficiency desensitizes Rb-/- cells to signals that trigger apoptosis during pituitary tumor development.
Oncogene 2003;22(3):361-9.
2002: Nguyen Thomas B; Manova Katia; Capodieci Paola; Lindon Catherine; Bottega Steve; Wang Xiang-Yuan; Refik-Rogers Jale; Pines Jonathon; Wolgemuth Debra J; Koff Andrew
Characterization and expression of mammalian cyclin b3, a prepachytene meiotic cyclin.
The Journal of biological chemistry 2002;277(44):41960-9.
2002: Vidal Anxo; Millard S Sean; Miller Jeffrey P; Koff Andrew
Rho activity can alter the translation of p27 mRNA and is important for RasV12-induced transformation in a manner dependent on p27 status.
The Journal of biological chemistry 2002;277(19):16433-40.
2002: Mahoney James A; Odin Joseph A; White Sarah M; Shaffer David; Koff Andrew; Casciola-Rosen Livia; Rosen Antony
The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis.
The Biochemical journal 2002;361(Pt 3):587-95.
2001: Gitig D M; Koff A
Cdk pathway: cyclin-dependent kinases and cyclin-dependent kinase inhibitors.
Molecular biotechnology 2001;19(2):179-88.
2001: Cipriano S C; Chen L; Burns K H; Koff A; Matzuk M M
Inhibin and p27 interact to regulate gonadal tumorigenesis.
Molecular endocrinology (Baltimore, Md.) 2001;15(6):985-96.
2001: Park M S; Koff A
Overview of the cell cycle.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2001;Chapter 8():Unit 8.1.
2001: Di Cristofano A; De Acetis M; Koff A; Cordon-Cardo C; Pandolfi P P
Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse.
Nature genetics 2001;27(2):222-4.
2001: Zezula J; Casaccia-Bonnefil P; Ezhevsky S A; Osterhout D J; Levine J M; Dowdy S F; Chao M V; Koff A
p21cip1 is required for the differentiation of oligodendrocytes independently of cell cycle withdrawal.
EMBO reports 2001;2(1):27-34.
2000: Millard S S; Vidal A; Markus M; Koff A
A U-rich element in the 5' untranslated region is necessary for the translation of p27 mRNA.
Molecular and cellular biology 2000;20(16):5947-59.
2000: Vairo G; Soos T J; Upton T M; Zalvide J; DeCaprio J A; Ewen M E; Koff A; Adams J M
Bcl-2 retards cell cycle entry through p27(Kip1), pRB relative p130, and altered E2F regulation.
Molecular and cellular biology 2000;20(13):4745-53.
2000: Vidal A; Koff A
Cell-cycle inhibitors: three families united by a common cause.
Gene 2000;247(1-2):1-15.
2000: Gitig D M; Koff A
Cdk pathway: cyclin-dependent kinases and cyclin-dependent kinase inhibitors.
Methods in molecular biology (Clifton, N.J.) 2000;142():109-23.
1999: Agus D B; Cordon-Cardo C; Fox W; Drobnjak M; Koff A; Golde D W; Scher H I
Prostate cancer cell cycle regulators: response to androgen withdrawal and development of androgen independence.
Journal of the National Cancer Institute 1999;91(21):1869-76.
1999: Tsutsui T; Hesabi B; Moons D S; Pandolfi P P; Hansel K S; Koff A; Kiyokawa H
Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity.
Molecular and cellular biology 1999;19(10):7011-9.
1999: Casaccia-Bonnefil P; Hardy R J; Teng K K; Levine J M; Koff A; Chao M V
Loss of p27Kip1 function results in increased proliferative capacity of oligodendrocyte progenitors but unaltered timing of differentiation.
Development (Cambridge, England) 1999;126(18):4027-37.
1999: Drissi H; Hushka D; Aslam F; Nguyen Q; Buffone E; Koff A; van Wijnen A; Lian J B; Stein J L; Stein G S
The cell cycle regulator p27kip1 contributes to growth and differentiation of osteoblasts.
Cancer research 1999;59(15):3705-11.
1999: Kolluri S K; Weiss C; Koff A; Göttlicher M
p27(Kip1) induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells.
Genes & development 1999;13(13):1742-53.
1999: Chou J L; Fan Z; DeBlasio T; Koff A; Rosen N; Mendelsohn J
Constitutive overexpression of cyclin D1 in human breast epithelial cells does not prevent G1 arrest induced by deprivation of epidermal growth factor.
Breast cancer research and treatment 1999;55(3):267-83.
1999: Park M S; Rosai J; Nguyen H T; Capodieci P; Cordon-Cardo C; Koff A
p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(11):6382-7.
1999: Beumer T L; Kiyokawa H; Roepers-Gajadien H L; van den Bos L A; Lock T M; Gademan I S; Rutgers D H; Koff A; de Rooij D G
Regulatory role of p27kip1 in the mouse and human testis.
Endocrinology 1999;140(4):1834-40.
1999: Nguyen H; Gitig D M; Koff A
Cell-free degradation of p27(kip1), a G1 cyclin-dependent kinase inhibitor, is dependent on CDK2 activity and the proteasome.
Molecular and cellular biology 1999;19(2):1190-201.
1998: Tong W; Kiyokawa H; Soos T J; Park M S; Soares V C; Manova K; Pollard J W; Koff A
The absence of p27Kip1, an inhibitor of G1 cyclin-dependent kinases, uncouples differentiation and growth arrest during the granulosa->luteal transition.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1998;9(9):787-94.
1998: Tikoo R; Osterhout D J; Casaccia-Bonnefil P; Seth P; Koff A; Chao M V
Ectopic expression of p27Kip1 in oligodendrocyte progenitor cells results in cell-cycle growth arrest.
Journal of neurobiology 1998;36(3):431-40.
1998: Cordon-Cardo C; Koff A; Drobnjak M; Capodieci P; Osman I; Millard S S; Gaudin P B; Fazzari M; Zhang Z F; Massague J; Scher H I
Distinct altered patterns of p27KIP1 gene expression in benign prostatic hyperplasia and prostatic carcinoma.
Journal of the National Cancer Institute 1998;90(17):1284-91.
1998: Millard S S; Koff A
Cyclin-dependent kinase inhibitors in restriction point control, genomic stability, and tumorigenesis.
Journal of cellular biochemistry. Supplement 1998;30-31():37-42.
1998: Soos T J; Park M; Kiyokawa H; Koff A
Regulation of the cell cycle by CDK inhibitors.
Results and problems in cell differentiation 1998;22():111-31.
1998: Kiyokawa H; Koff A
Roles of cyclin-dependent kinase inhibitors: lessons from knockout mice.
Current topics in microbiology and immunology 1998;227():105-20.
1997: Osman I; Scher H; Zhang Z F; Soos T J; Hamza R; Eissa S; Khaled H; Koff A; Cordon-Cardo C
Expression of cyclin D1, but not cyclins E and A, is related to progression in bilharzial bladder cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(12 Pt 1):2247-51.
1997: Casaccia-Bonnefil P; Tikoo R; Kiyokawa H; Friedrich V; Chao M V; Koff A
Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27Kip1.
Genes & development 1997;11(18):2335-46.
1997: Millard S S; Yan J S; Nguyen H; Pagano M; Kiyokawa H; Koff A
Enhanced ribosomal association of p27(Kip1) mRNA is a mechanism contributing to accumulation during growth arrest.
The Journal of biological chemistry 1997;272(11):7093-8.
1997: Tikoo R; Casaccia-Bonnefil P; Chao M V; Koff A
Changes in cyclin-dependent kinase 2 and p27kip1 accompany glial cell differentiation of central glia-4 cells.
The Journal of biological chemistry 1997;272(1):442-7.
1996: Missero C; Di Cunto F; Kiyokawa H; Koff A; Dotto G P
The absence of p21Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression.
Genes & development 1996;10(23):3065-75.
1996: Luo Y; Marx S O; Kiyokawa H; Koff A; Massagué J; Marks A R
Rapamycin resistance tied to defective regulation of p27Kip1.
Molecular and cellular biology 1996;16(12):6744-51.
1996: Onel K; Koff A; Bennett R L; Unrau P; Holloman W K
The REC1 gene of Ustilago maydis, which encodes a 3'-->5' exonuclease, couples DNA repair and completion of DNA synthesis to a mitotic checkpoint.
Genetics 1996;143(1):165-74.
1996: Kiyokawa H; Kineman R D; Manova-Todorova K O; Soares V C; Hoffman E S; Ono M; Khanam D; Hayday A C; Frohman L A; Koff A
Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).
Cell 1996;85(5):721-32.
1996: Claudio P P; De Luca A; Howard C M; Baldi A; Firpo E J; Koff A; Paggi M G; Giordano A
Functional analysis of pRb2/p130 interaction with cyclins.
Cancer research 1996;56(9):2003-8.
1996: Wu X; Rubin M; Fan Z; DeBlasio T; Soos T; Koff A; Mendelsohn J
Involvement of p27KIP1 in G1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody.
Oncogene 1996;12(7):1397-403.
1996: Hoffman E S; Passoni L; Crompton T; Leu T M; Schatz D G; Koff A; Owen M J; Hayday A C
Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo.
Genes & development 1996;10(8):948-62.
1996: Soos T J; Kiyokawa H; Yan J S; Rubin M S; Giordano A; DeBlasio A; Bottega S; Wong B; Mendelsohn J; Koff A
Formation of p27-CDK complexes during the human mitotic cell cycle.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996;7(2):135-46.
1995: Fan Z; Lu Y; Wu X; DeBlasio A; Koff A; Mendelsohn J
Prolonged induction of p21Cip1/WAF1/CDK2/PCNA complex by epidermal growth factor receptor activation mediates ligand-induced A431 cell growth inhibition.
The Journal of cell biology 1995;131(1):235-42.
1995: Bullrich F; MacLachlan T K; Sang N; Druck T; Veronese M L; Allen S L; Chiorazzi N; Koff A; Heubner K; Croce C M
Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer.
Cancer research 1995;55(6):1199-205.
1995: Koff A; Polyak K
p27KIP1, an inhibitor of cyclin-dependent kinases.
Progress in cell cycle research 1995;1():141-7.
1994: Polyak K; Lee M H; Erdjument-Bromage H; Koff A; Roberts J M; Tempst P; Massagué J
Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals.
Cell 1994;78(1):59-66.
1994: Firpo E J; Koff A; Solomon M J; Roberts J M
Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes.
Molecular and cellular biology 1994;14(7):4889-901.
1994: Polyak K; Kato J Y; Solomon M J; Sherr C J; Massague J; Roberts J M; Koff A
p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.
Genes & development 1994;8(1):9-22.
1994: Roberts J M; Koff A; Polyak K; Firpo E; Collins S; Ohtsubo M; Massagué J
Cyclins, Cdks, and cyclin kinase inhibitors.
Cold Spring Harbor symposia on quantitative biology 1994;59():31-8.
1993: Koff A; Ohtsuki M; Polyak K; Roberts J M; Massagué J
Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta.
Science (New York, N.Y.) 1993;260(5107):536-9.
1992: Koff A; Giordano A; Desai D; Yamashita K; Harper J W; Elledge S; Nishimoto T; Morgan D O; Franza B R; Roberts J M
Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle.
Science (New York, N.Y.) 1992;257(5077):1689-94.
1991: Koff A; Cross F; Fisher A; Schumacher J; Leguellec K; Philippe M; Roberts J M
Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family.
Cell 1991;66(6):1217-28.
1991: Koff A; Schwedes J F; Tegtmeyer P
Herpes simplex virus origin-binding protein (UL9) loops and distorts the viral replication origin.
Journal of virology 1991;65(6):3284-92.
1988: Koff A; Tegtmeyer P
Characterization of major recognition sequences for a herpes simplex virus type 1 origin-binding protein.
Journal of virology 1988;62(11):4096-103.
1987: Deb S; Tsui S; Koff A; DeLucia A L; Parsons R; Tegtmeyer P
The T-antigen-binding domain of the simian virus 40 core origin of replication.
Journal of virology 1987;61(7):2143-9.
1986: Deb S; DeLucia A L; Koff A; Tsui S; Tegtmeyer P
The adenine-thymine domain of the simian virus 40 core origin directs DNA bending and coordinately regulates DNA replication.
Molecular and cellular biology 1986;6(12):4578-84.
1986: Deb S; DeLucia A L; Baur C P; Koff A; Tegtmeyer P
Domain structure of the simian virus 40 core origin of replication.
Molecular and cellular biology 1986;6(5):1663-70.

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Andrew Koff

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