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Kathy Kohlhaas

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Daniel B Timmermann; J K Christensen; E Ø Nielsen; G M Olsen; Tino Dyhring; M Grunnet; A-M Jacobsen; Kathy L Kohlhaas; Dan Peters; K Sandager-Nielsen; M Smith; Philip K Ahring
Augmentation of cognitive function by NS9283, a stoichiometry-dependent positive allosteric modulator of α2- and α4-containing nicotinic acetylcholine receptors.
Kathy L Kohlhaas; Robert S Bitner; Murali Gopalakrishnan; Lynne E Rueter
Effects of α7 nicotinic acetylcholine receptor agonists on antipsychotic efficacy in a preclinical mouse model of psychosis.
Robert S Bitner; William H Bunnelle; Michael W Decker; Karla U Drescher; Kathy L Kohlhaas; Stella Markosyan; Kennan Marsh; Arthur L Nikkel; Kaitlin E Browman; Richard J Radek; David J Anderson; Jerry J Buccafusco; Murali Gopalakrishnan
In vivo pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107: preclinical considerations in Alzheimer's disease.

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All Publications

2012: Daniel B Timmermann; J K Christensen; E Ø Nielsen; G M Olsen; Tino Dyhring; M Grunnet; A-M Jacobsen; Kathy L Kohlhaas; Dan Peters; K Sandager-Nielsen; M Smith; Philip K Ahring
Augmentation of cognitive function by NS9283, a stoichiometry-dependent positive allosteric modulator of α2- and α4-containing nicotinic acetylcholine receptors.
British journal of pharmacology 2012;167(1):164-82.
2012: Kathy L Kohlhaas; Robert S Bitner; Murali Gopalakrishnan; Lynne E Rueter
Effects of α7 nicotinic acetylcholine receptor agonists on antipsychotic efficacy in a preclinical mouse model of psychosis.
Psychopharmacology 2012;220(4):823-33.
2010: Robert S Bitner; William H Bunnelle; Michael W Decker; Karla U Drescher; Kathy L Kohlhaas; Stella Markosyan; Kennan Marsh; Arthur L Nikkel; Kaitlin E Browman; Richard J Radek; David J Anderson; Jerry J Buccafusco; Murali Gopalakrishnan
In vivo pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107: preclinical considerations in Alzheimer's disease.
The Journal of pharmacology and experimental therapeutics 2010;334(3):875-86.
2010: Richard J Radek; Kathy L Kohlhaas; Lynne E Rueter; Eric G Mohler
Treating the cognitive deficits of schizophrenia with alpha4beta2 neuronal nicotinic receptor agonists.
Current pharmaceutical design 2010;16(3):309-22.
2007: Daniel B Timmermann; Jens Halvard Grønlien; Kathy L Kohlhaas; Elsebet Ø Nielsen; Eva Dam; Tino Dyhring; Philip K Ahring; Dan Peters; Dorte Holst; Jeppe K Christensen; Jeppe K Chrsitensen; John Malysz; Jens Halvard Gronlien; Murali Gopalakrishnan; Gunnar M Olsen
An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo.
The Journal of pharmacology and experimental therapeutics 2007;323(1):294-307.
2007: Mark A Matulenko; Ernest S Paight; Robin R Frey; Arthur Gomtsyan; Stanley Didomenico; Meiqun Jiang; Abel Lee; Andrew O Stewart; Haixia Yu; Kathy L Kohlhaas; Easaw Alexander; Steve McGaraughty; Joe Mikusa; Kennan Marsh; Steven W Muchmore; Clarissa L Jakob; Elizabeth A Kowaluk; Michael F Jarvis; Shripad S Bhagwat
4-amino-5-aryl-6-arylethynylpyrimidines: structure-activity relationships of non-nucleoside adenosine kinase inhibitors.
Bioorganic & medicinal chemistry 2007;15(4):1586-605.
2006: Jennifer M Frost; William H Bunnelle; Karin R Tietje; David J Anderson; Lynne E Rueter; Peter Curzon; Carol S Surowy; Jianguo Ji; Jerome F Daanen; Kathy L Kohlhaas; Michael J Buckley; Rodger F Henry; Tino Dyhring; Philip K Ahring; Michael D Meyer
Synthesis and structure-activity relationships of 3,8-diazabicyclo[4.2.0]octane ligands, potent nicotinic acetylcholine receptor agonists.
Journal of medicinal chemistry 2006;49(26):7843-53.
2006: Min Zhang; Michael Ballard; Kathy L Kohlhaas; Kaitlin E Browman; Ana-Lucia Jongen-Rêlo; Liliane Unger; Gerard B Fox; Gerhard Gross; Michael W Decker; Karla U Drescher; Lynne E Rueter
Effect of dopamine D3 antagonists on PPI in DBA/2J mice or PPI deficit induced by neonatal ventral hippocampal lesions in rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(7):1382-92.
2005: Richard J Perner; Abel Lee; Meiqun Jiang; Yu Gui Gu; Stanley Didomenico; Erol K Bayburt; Easaw Alexander; Kathy L Kohlhaas; Michael F Jarvis; Elizabeth L Kowaluk; Shripad S Bhagwat
Synthesis and biological evaluation of 6,7-disubstituted 4-aminopyrido[2,3-d]pyrimidines as adenosine kinase inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(11):2803-7.
2005: Mark A Matulenko; Abel Lee; Meiqun Jiang; Robin R Frey; Marlon D Cowart; Erol K Bayburt; Stanley Didomenico; Gregory A Gfesser; Arthur Gomtsyan; Guo Zhu Zheng; Jeffrey A McKie; Andrew O Stewart; Haixia Yu; Kathy L Kohlhaas; Easaw Alexander; Steve McGaraughty; Carol T Wismer; Joe Mikusa; Kennan Marsh; Ronald D Snyder; Marilyn S Diehl; Elizabeth A Kowaluk; Michael F Jarvis; Shripad S Bhagwat
5-(3-Bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-ylamine: structure-activity relationships of 7-substituted heteroaryl analogs as non-nucleoside adenosine kinase inhibitors.
Bioorganic & medicinal chemistry 2005;13(11):3705-20.
2005: Gilles Dube; Kathy L Kohlhaas; Lynne E Rueter; Carol S Surowy; Michael D Meyer; Clark A Briggs
Loss of functional neuronal nicotinic receptors in dorsal root ganglion neurons in a rat model of neuropathic pain.
Neuroscience letters 2005;376(1):29-34.
2004: Lynne E Rueter; Michael Ballard; Kelly B Gallagher; Ana M Basso; Peter Curzon; Kathy L Kohlhaas
Chronic low dose risperidone and clozapine alleviate positive but not negative symptoms in the rat neonatal ventral hippocampal lesion model of schizophrenia.
Psychopharmacology 2004;176(3-4):312-9.
2003: Richard J Perner; Yu Gui Gu; Abel Lee; Erol K Bayburt; Jeffrey A McKie; Easaw Alexander; Kathy L Kohlhaas; Carol T Wismer; Joe Mikusa; Michael F Jarvis; Elizabeth A Kowaluk; Shripad S Bhagwat
5,6,7-trisubstituted 4-aminopyrido[2,3-d]pyrimidines as novel inhibitors of adenosine kinase.
Journal of medicinal chemistry 2003;46(24):5249-57.
2003: Guo Zhu Zheng; Yue Mao; Abel Lee; John K Pratt; John R Koenig; Richard J Perner; Marlon D Cowart; Gregory A Gfesser; Steve McGaraughty; Katharine L Chu; Chang Zhu; Haixia Yu; Kathy L Kohlhaas; Easaw Alexander; Carol T Wismer; Joe Mikusa; Michael F Jarvis; Elizabeth A Kowaluk; Andrew O Stewart
Adenosine kinase inhibitors: polar 7-substitutent of pyridopyrimidine derivatives improving their locomotor selectivity.
Bioorganic & medicinal chemistry letters 2003;13(18):3041-4.
2003: Lynne E Rueter; Kathy L Kohlhaas; Peter Curzon; Carol S Surowy; Michael D Meyer
Peripheral and central sites of action for A-85380 in the spinal nerve ligation model of neuropathic pain.
Pain 2003;103(3):269-76.
2002: Arthur Gomtsyan; Stanley Didomenico; Abel Lee; Mark A Matulenko; Ki Kim; Elizabeth A Kowaluk; Carol T Wismer; Joe Mikusa; Haixia Yu; Kathy L Kohlhaas; Michael F Jarvis; Shripad S Bhagwat
Design, synthesis, and structure-activity relationship of 6-alkynylpyrimidines as potent adenosine kinase inhibitors.
Journal of medicinal chemistry 2002;45(17):3639-48.
2002: Michael F Jarvis; Haixia Yu; Steve McGaraughty; Carol T Wismer; Joe Mikusa; Chang Zhu; Katharine Chu; Kathy L Kohlhaas; Marlon D Cowart; Chih Hung Lee; Andrew O Stewart; Bryan Cox; James S Polakowski; Elizabeth A Kowaluk
Analgesic and anti-inflammatory effects of A-286501, a novel orally active adenosine kinase inhibitor.
Pain 2002;96(1-2):107-18.
2001: Chih Hung Lee; Jerome F Daanen; Meiqun Jiang; Haixia Yu; Kathy L Kohlhaas; K Alexander; Michael F Jarvis; E L Kowaluk; Shripad S Bhagwat
Synthesis and biological evaluation of clitocine analogues as adenosine kinase inhibitors.
Bioorganic & medicinal chemistry letters 2001;11(18):2419-22.
2001: Guo Zhu Zheng; C Lee; John K Pratt; Richard J Perner; M Q Jiang; Arthur Gomtsyan; Mark A Matulenko; Yue Mao; John R Koenig; Ki H Kim; Steven W Muchmore; Haixia Yu; Kathy L Kohlhaas; Easaw Alexander; Steve McGaraughty; Katharine L Chu; Carol T Wismer; Joe Mikusa; Michael F Jarvis; Kennan Marsh; Elizabeth A Kowaluk; Shripad S Bhagwat; Andrew O Stewart
Pyridopyrimidine analogues as novel adenosine kinase inhibitors.
Bioorganic & medicinal chemistry letters 2001;11(16):2071-4.
2001: Marlon D Cowart; Chih Hung Lee; Gregory A Gfesser; Erol K Bayburt; Shripad S Bhagwat; Andrew O Stewart; Haixia Yu; Kathy L Kohlhaas; Steve McGaraughty; Carol T Wismer; Joe Mikusa; Chang Zhu; Easaw Alexander; Michael F Jarvis; Elizabeth A Kowaluk
Structure-activity studies of 5-substituted pyridopyrimidines as adenosine kinase inhibitors.
Bioorganic & medicinal chemistry letters 2001;11(1):83-6.
2000: Michael F Jarvis; Haixia Yu; Kathy L Kohlhaas; K Alexander; Chih Hung Lee; Meiqun Jiang; Shripad S Bhagwat; Michael Williams; Elizabeth A Kowaluk
ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I. In vitro characterization and acute antinociceptive effects in the mouse.
The Journal of pharmacology and experimental therapeutics 2000;295(3):1156-64.
1999: Elizabeth A Kowaluk; Kathy L Kohlhaas; AW Bannon; KL Gunther; James J Lynch; Michael F Jarvis
Characterization of the effects of adenosine kinase inhibitors on acute thermal nociception in mice.
Pharmacology, biochemistry, and behavior 1999;63(1):83-91.
1998: Marlon D Cowart; Elizabeth A Kowaluk; Jerome F Daanen; Kathy L Kohlhaas; Easaw Alexander; Frank L Wagenaar; James Kerwin
Nitroaromatic amino acids as inhibitors of neuronal nitric oxide synthase.
Journal of medicinal chemistry 1998;41(14):2636-42.
1993: J A Mitchell; Kathy L Kohlhaas; R Sorrentino; T D Warner; Ferid Murad; JR Vane
Induction by endotoxin of nitric oxide synthase in the rat mesentery: lack of effect on action of vasoconstrictors.
British journal of pharmacology 1993;109(1):265-70.
1992: T Matsumoto; J A Mitchell; H H Schmidt; Kathy L Kohlhaas; T D Warner; Ulrich Förstermann; Ferid Murad
Nitric oxide synthase in ferret brain: localization and characterization.
British journal of pharmacology 1992;107(3):849-52.
1992: J A Mitchell; Kathy L Kohlhaas; T Matsumoto; Jennifer Pollock; Ulrich Förstermann; T D Warner; H H Schmidt; Ferid Murad
Induction of NADPH-dependent diaphorase and nitric oxide synthase activity in aortic smooth muscle and cultured macrophages.
Molecular pharmacology 1992;41(6):1163-8.
1992: Ulrich Förstermann; H H Schmidt; Kathy L Kohlhaas; Ferid Murad
Induced RAW 264.7 macrophages express soluble and particulate nitric oxide synthase: inhibition by transforming growth factor-beta.
European journal of pharmacology 1992;225(2):161-5.