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Alexander Kohlmann

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Oligonucleotide Array Sequence Analysis

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Vera Grossmann; Claudia Haferlach; Torsten Haferlach; Wolfgang Kern; Alexander Kohlmann; Niroshan Nadarajah; Andreas Roller; Christiane Eder; Annette Fasan; Elisa Stopp; Sandra Weissmann; Susanne Schnittger
CEBPA double-mutated acute myeloid leukaemia harbours concomitant molecular mutations in 76·8% of cases with TET2 and GATA2 alterations impacting prognosis.
Vera Grossmann; Claudia Haferlach; Torsten Haferlach; Wolfgang Kern; Franziska Poetzinger; Andreas Roller; Sonja Schindela; Susanne Schnittger; Kathrin Stadler; Sandra Weissmann; Frauke Bellos; Alexander Kohlmann
The molecular profile of adult T-cell acute lymphoblastic leukemia: mutations in RUNX1 and DNMT3A are associated with poor prognosis in T-ALL.
A Fasan; V Grossmann; Claudia Haferlach; Torsten Haferlach; Wolfgang Kern; Alexander Kohlmann; Frank Dicker; C Eder; Susanne Schnittger
GATA2 mutations are frequent in intermediate-risk karyotype AML with biallelic CEBPA mutations and are associated with favorable prognosis.

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All Publications

2013: Vera Grossmann; Claudia Haferlach; Torsten Haferlach; Wolfgang Kern; Alexander Kohlmann; Niroshan Nadarajah; Andreas Roller; Christiane Eder; Annette Fasan; Elisa Stopp; Sandra Weissmann; Susanne Schnittger
CEBPA double-mutated acute myeloid leukaemia harbours concomitant molecular mutations in 76·8% of cases with TET2 and GATA2 alterations impacting prognosis.
British journal of haematology 2013;161(5):649-58.
2013: Vera Grossmann; Claudia Haferlach; Torsten Haferlach; Wolfgang Kern; Franziska Poetzinger; Andreas Roller; Sonja Schindela; Susanne Schnittger; Kathrin Stadler; Sandra Weissmann; Frauke Bellos; Alexander Kohlmann
The molecular profile of adult T-cell acute lymphoblastic leukemia: mutations in RUNX1 and DNMT3A are associated with poor prognosis in T-ALL.
Genes, chromosomes & cancer 2013;52(4):410-22.
2013: A Fasan; V Grossmann; Claudia Haferlach; Torsten Haferlach; Wolfgang Kern; Alexander Kohlmann; Frank Dicker; C Eder; Susanne Schnittger
GATA2 mutations are frequent in intermediate-risk karyotype AML with biallelic CEBPA mutations and are associated with favorable prognosis.
Leukemia 2013;27(2):482-5.
2013: Annette Fasan; Vera Grossmann; Claudia Haferlach; Torsten Haferlach; Wolfgang Kern; Alexander Kohlmann; Andreas Roller; Tamara Alpermann; Christiane Eder; Susanne Schnittger
Frequency and prognostic impact of CEBPA proximal, distal and core promoter methylation in normal karyotype AML: a study on 623 cases.
PloS one 2013;8(2):e54365.
2013: Susanne Schnittger; P Staib; H-E Wichmann; T Alpermann; C Eder; A Fasan; V Grossmann; Claudia Haferlach; T Illig; S Jeromin; Wolfgang Kern; N Klopp; Alexander Kohlmann; K-A Kreuzer; Rudolf Peceny; C Schmid; Norbert Schmitz; Torsten Haferlach
ASXL1 exon 12 mutations are frequent in AML with intermediate risk karyotype and are independently associated with an adverse outcome.
Leukemia 2013;27(1):82-91.
2012: Claudia Haferlach; Torsten Haferlach; Wolfgang Kern; Alexander Kohlmann; Sonja Schindela; Ulrike Bacher; Vera Grossmann; Melanie Zenger; Susanne Schnittger
Three novel cytogenetically cryptic EVI1 rearrangements associated with increased EVI1 expression and poor prognosis identified in 27 acute myeloid leukemia cases.
Genes, chromosomes & cancer 2012;51(12):1079-85.
2012: Susanne Schnittger; Madlen Ulke; Tamara Alpermann; Ulrike Bacher; Frank Dicker; Christiane Eder; Vera Grossmann; Claudia Haferlach; Wolfgang Kern; Alexander Kohlmann; Andreas Kowarsch; Andreas Reiter; Torsten Haferlach
Use of CBL exon 8 and 9 mutations in diagnosis of myeloproliferative neoplasms and myelodysplastic/myeloproliferative disorders: an analysis of 636 cases.
Haematologica 2012;97(12):1890-4.
2012: Manja Meggendorfer; Seishi Ogawa; Andreas Roller; Kenichi Yoshida; Tamara Alpermann; Frank Dicker; Christiane Eder; Vera Grossmann; Claudia Haferlach; Torsten Haferlach; Wolfgang Kern; H Phillip Koeffler; Alexander Kohlmann; Susanne Schnittger
SRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML).
Blood 2012;120(15):3080-8.
2012: Vera Grossmann; Frank Dicker; Christiane Eder; Torsten Haferlach; Wolfgang Kern; Alexander Kohlmann; Karl-Anton Kreuzer; Andreas Roller; Christoph Schmid; Susanne Schnittger; Hubert Serve; Peter Staib; Clemens-Martin Wendtner; Claudia Haferlach
A novel hierarchical prognostic model of AML solely based on molecular mutations.
Blood 2012;120(15):2963-72.
2012: Susanne Schnittger; Wolfgang Kern; Alexander Kohlmann; Tamara Alpermann; Ulrike Bacher; Frank Dicker; Christiane Eder; Vera Grossmann; Claudia Haferlach; Torsten Haferlach
Molecular analyses of 15,542 patients with suspected BCR-ABL1-negative myeloproliferative disorders allow to develop a stepwise diagnostic workflow.
Haematologica 2012;97(10):1582-5.
2012: Ulrike Bacher; Vera Grossmann; Claudia Haferlach; Wolfgang Kern; Alexander Kohlmann; Andreas Kowarsch; Katja Macijewski; Niroshan Nadarajah; Susanne Schnittger; Tamara Alpermann; Torsten Haferlach
Multilineage dysplasia does not influence prognosis in CEBPA-mutated AML, supporting the WHO proposal to classify these patients as a unique entity.
Blood 2012;119(20):4719-22.
2012: Vera Grossmann; Tamara Alpermann; Valentina Artusi; Ulrike Bacher; Martin Dugas; Torsten Haferlach; Wolfgang Kern; Hans-Ulrich Klein; Alexander Kohlmann; Susanne Schnittger; Claudia Haferlach
EZH2 mutations and their association with PICALM-MLLT10 positive acute leukaemia.
British journal of haematology 2012;157(3):387-90.
2012: S Weissmann; A Kowarsch; N Nadarajah; Susanne Schnittger; T Alpermann; Frank Dicker; C Eder; A Fasan; V Grossmann; Claudia Haferlach; Torsten Haferlach; Wolfgang Kern; Alexander Kohlmann
Landscape of TET2 mutations in acute myeloid leukemia.
Leukemia 2012;26(5):934-42.
2012: V Grossmann; Ulrike Bacher; K Butschalowski; Frank Dicker; T Haferlach; S Jeromin; W Kern; Alexander Kohlmann; A Roller; Susanne Schnittger; Claudia Haferlach
Expression of CEBPA is reduced in RUNX1-mutated acute myeloid leukemia.
Blood cancer journal 2012;2():e86.
2012: V Grossmann; V Artusi; U Bacher; T Haferlach; W Kern; Alexander Kohlmann; N Nadarajah; S Schnittger; C Haferlach
Molecular analysis of RAS-RAF tyrosine-kinase signaling pathway alterations in patients with plasma cell myeloma.
Blood cancer journal 2012;2():e85.
2011: Hans-Ulrich Klein; Christoph Bartenhagen; Alexander Kohlmann; Vera Grossmann; Christian Ruckert; Torsten Haferlach; Martin Dugas
R453Plus1Toolbox: an R/Bioconductor package for analyzing Roche 454 Sequencing data.
Bioinformatics (Oxford, England) 2011;27(8):1162-3.
2009: Hans-Ulrich Klein; Christian Ruckert; Alexander Kohlmann; Lars Bullinger; Christian Thiede; Torsten Haferlach; Martin Dugas
Quantitative comparison of microarray experiments with published leukemia related gene expression signatures.
BMC bioinformatics 2009;10():422.
2007: Katharina Tschoep; Alexander Kohlmann; Marcus Schlemmer; Torsten Haferlach; Rolf Issels
Gene expression profiling in sarcomas.
Critical reviews in oncology/hematology 2007;63(2):111-24.
2006: Claudia Schoch; Alexander Kohlmann; Martin Dugas; Wolfgang Kern; Susanne Schnittger; Torsten Haferlach
Impact of trisomy 8 on expression of genes located on chromosome 8 in different AML subgroups.
Genes, chromosomes & cancer 2006;45(12):1164-8.
2006: Paul Unschuld; J Dächsel; Frédéric Darios; Alexander Kohlmann; E Casademunt; K Lehmann-Horn; M Dichgans; Merle Ruberg; Alexis Brice; Thomas Gasser; Christoph B Lücking
Parkin modulates gene expression in control and ceramide-treated PC12 cells.
Molecular biology reports 2006;33(1):13-32.
2006: M Dugas; F Weninger; Sylvia Merk; Alexander Kohlmann; T Haferlach
A generic concept for large-scale microarray analysis dedicated to medical diagnostics.
Methods of information in medicine 2006;45(2):146-52.
2006: Alexander Kohlmann; Wolfgang Kern; Wolfgang Hiddemann; Torsten Haferlach
Classification of AML by DNA-oligonucleotide microarrays.
Methods in molecular medicine 2006;125():213-40.
2005: Florian Kuchenbauer; Wolfgang Kern; Claudia Schoch; Alexander Kohlmann; Wolfgang Hiddemann; Torsten Haferlach; Susanne Schnittger
Detailed analysis of FLT3 expression levels in acute myeloid leukemia.
Haematologica 2005;90(12):1617-25.
2005: Torsten Haferlach; Alexander Kohlmann; Susanne Schnittger; Martin Dugas; Wolfgang Hiddemann; Wolfgang Kern; Claudia Schoch
Global approach to the diagnosis of leukemia using gene expression profiling.
Blood 2005;106(4):1189-98.
2005: Frank Dicker; Sonja Rauhut; Alexander Kohlmann; Wolfgang Kern; Claudia Schoch; Torsten Haferlach; Susanne Schnittger
Re: Prognostic significance of a short sequence insertion in the MCL-1 promoter in chronic lymphocytic leukemia.
Journal of the National Cancer Institute 2005;97(14):1092-3; author reply 1093-5.
2005: Claudia Schoch; Alexander Kohlmann; Martin Dugas; Wolfgang Kern; Wolfgang Hiddemann; Susanne Schnittger; Torsten Haferlach
Genomic gains and losses influence expression levels of genes located within the affected regions: a study on acute myeloid leukemias with trisomy 8, 11, or 13, monosomy 7, or deletion 5q.
Leukemia 2005;19(7):1224-8.
2005: Claudia Schoch; Wolfgang Kern; Alexander Kohlmann; Wolfgang Hiddemann; Susanne Schnittger; Torsten Haferlach
Acute myeloid leukemia with a complex aberrant karyotype is a distinct biological entity characterized by genomic imbalances and a specific gene expression profile.
Genes, chromosomes & cancer 2005;43(3):227-38.
2005: Wolfgang Kern; Alexander Kohlmann; Susanne Schnittger; Claudia Schoch; Torsten Haferlach
Role of gene expression profiling for diagnosing acute leukemias.
Reviews in clinical and experimental hematology 2005;9(1):E1.
2005: Alexander Kohlmann; Claudia Schoch; Martin Dugas; Susanne Schnittger; Wolfgang Hiddemann; Wolfgang Kern; Torsten Haferlach
New insights into MLL gene rearranged acute leukemias using gene expression profiling: shared pathways, lineage commitment, and partner genes.
Leukemia 2005;19(6):953-64.
2005: Torsten Haferlach; Alexander Kohlmann; Susanne Schnittger; Martin Dugas; Wolfgang Hiddemann; Wolfgang Kern; Claudia Schoch
AML M3 and AML M3 variant each have a distinct gene expression signature but also share patterns different from other genetically defined AML subtypes.
Genes, chromosomes & cancer 2005;43(2):113-27.
2005: Alexander Kohlmann; Claudia Schoch; Martin Dugas; Sonja Rauhut; Felix Weninger; Susanne Schnittger; Wolfgang Kern; Torsten Haferlach
Pattern robustness of diagnostic gene expression signatures in leukemia.
Genes, chromosomes & cancer 2005;42(3):299-307.
2004: Wei Xiang; Otto Windl; Gerda Wünsch; Martin Dugas; Alexander Kohlmann; Nicola Dierkes; Ingo M Westner; Hans A Kretzschmar
Identification of differentially expressed genes in scrapie-infected mouse brains by using global gene expression technology.
Journal of virology 2004;78(20):11051-60.
2004: Wolfgang Kern; Alexander Kohlmann; Susanne Schnittger; Wolfgang Hiddemann; Claudia Schoch; Torsten Haferlach
Gene expression profiling as a diagnostic tool in acute myeloid leukemia.
American journal of pharmacogenomics : genomics-related research in drug development and clinical practice 2004;4(4):225-37.
2004: Alexander Kohlmann; Claudia Schoch; Susanne Schnittger; Martin Dugas; Wolfgang Hiddemann; Wolfgang Kern; Torsten Haferlach
Pediatric acute lymphoblastic leukemia (ALL) gene expression signatures classify an independent cohort of adult ALL patients.
Leukemia 2004;18(1):63-71.
2003: Torsten Haferlach; Alexander Kohlmann; Wolfgang Kern; Wolfgang Hiddemann; Susanne Schnittger; Claudia Schoch
Gene expression profiling as a tool for the diagnosis of acute leukemias.
Seminars in hematology 2003;40(4):281-95.
2003: Katharina Tschoep; Alexander Kohlmann; Marcus Schlemmer; Torsten Haferlach; Rolf Issels
[Gene expression analysis using DNA microarrays in soft tissue and bone tumors].
Deutsche medizinische Wochenschrift (1946) 2003;128(39):2030-6.
2003: Wolfgang Kern; Alexander Kohlmann; Christian Wuchter; Susanne Schnittger; Claudia Schoch; Susanne Mergenthaler; Richard Ratei; Wolf-Dieter Ludwig; Wolfgang Hiddemann; Torsten Haferlach
Correlation of protein expression and gene expression in acute leukemia.
Cytometry. Part B, Clinical cytometry 2003;55(1):29-36.
2003: Annika Elsässer; Michael Franzen; Alexander Kohlmann; Martin Weisser; Susanne Schnittger; Claudia Schoch; Venkateshwar A Reddy; Sebastien A Burel; Dong-Er Zhang; Marius Ueffing; Daniel G Tenen; Wolfgang Hiddemann; Gerhard Behre
The fusion protein AML1-ETO in acute myeloid leukemia with translocation t(8;21) induces c-jun protein expression via the proximal AP-1 site of the c-jun promoter in an indirect, JNK-dependent manner.
Oncogene 2003;22(36):5646-57.
2003: Alexander Kohlmann; Claudia Schoch; Susanne Schnittger; Martin Dugas; Wolfgang Hiddemann; Wolfgang Kern; Torsten Haferlach
Molecular characterization of acute leukemias by use of microarray technology.
Genes, chromosomes & cancer 2003;37(4):396-405.
2003: Janki Rangatia; Rajani K Vangala; Sheo M Singh; Abdul A Peer Zada; Annika Elsässer; Alexander Kohlmann; Torsten Haferlach; Daniel G Tenen; Wolfgang Hiddemann; Gerhard Behre
Elevated c-Jun expression in acute myeloid leukemias inhibits C/EBPalpha DNA binding via leucine zipper domain interaction.
Oncogene 2003;22(30):4760-4.
2003: W Hiddemann; T Haferlach; C Schoch; Gerhard Behre; Alexander Kohlmann; W Kern; Michaela Feuring-Buske; Stefan K Bohlander
New insights into the biology of acute myeloid leukemia and their impact on treatment.
Verhandlungen der Deutschen Gesellschaft für Pathologie 2003;87():72-8.
2002: Alexander Kohlmann; Claudia Schoch; Susanne Schnittger; W Kern; Torsten Haferlach
[Diagnosis of leukemia using microarray technology].
Deutsche medizinische Wochenschrift (1946) 2002;127(42):2216-22.
2002: Claudia Schoch; Alexander Kohlmann; Susanne Schnittger; Benedikt Brors; Martin Dugas; Susanne Mergenthaler; Wolfgang Kern; Wolfgang Hiddemann; Roland Eils; Torsten Haferlach
Acute myeloid leukemias with reciprocal rearrangements can be distinguished by specific gene expression profiles.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(15):10008-13.
2002: Martin Dugas; Claudia Schoch; Susanne Schnittger; Alexander Kohlmann; Wolfgang Kern; Torsten Haferlach; Karl Uberla
Impact of integrating clinical and genetic information.
In silico biology 2002;2(3):383-91.