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Donald Kohn

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Procedures

Living Beings

Anatomy

Physiology

Devices

Gene Transfer Techniques

Disorders

Severe Combined Immunodeficiency

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Co-Publications
Name
26
Weinberg, Kenneth
24
Crooks, Gay
19
Yu, Xiao-Jin
19
Parkman, Robertson
17
Nolta, Jan
16
Pepper, Karen
15
Skelton, Dianne
14
Bahner, Ingrid
12
Carbonaro, Denise
11
Kapoor, Neena
9
Tarantal, Alice
9
Shah, Ami
9
Bauer, Gerhard
8
Petersen, Denise
8
Smogorzewska, Elzbieta Monika

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Publications

TOP 3
Shaw K L; Pais E; Ge S; Hardee C; Skelton D; Hollis R P; Crooks G M; Kohn D B
Lentiviral vectors with amplified beta cell-specific gene expression.
Gruber Tanja A; Shah Ami J; Hernandez Michelle; Crooks Gay M; Abdel-Azim Hisham; Gupta Sudhir; McKnight Sean; White Drew; Kapoor Neena; Kohn Donald B
Clinical and genetic heterogeneity in Omenn syndrome and severe combined immune deficiency.
Lin Malinda; Epport Karen; Azen Colleen; Parkman Robertson; Kohn Donald B; Shah Ami J
Long-term neurocognitive function of pediatric patients with severe combined immune deficiency (SCID): pre- and post-hematopoietic stem cell transplant (HSCT).

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All Publications

2009: Shaw K L; Pais E; Ge S; Hardee C; Skelton D; Hollis R P; Crooks G M; Kohn D B
Lentiviral vectors with amplified beta cell-specific gene expression.
Gene therapy 2009;16(8):998-1008.
2009: Gruber Tanja A; Shah Ami J; Hernandez Michelle; Crooks Gay M; Abdel-Azim Hisham; Gupta Sudhir; McKnight Sean; White Drew; Kapoor Neena; Kohn Donald B
Clinical and genetic heterogeneity in Omenn syndrome and severe combined immune deficiency.
Pediatric transplantation 2009;13(2):244-50.
2009: Lin Malinda; Epport Karen; Azen Colleen; Parkman Robertson; Kohn Donald B; Shah Ami J
Long-term neurocognitive function of pediatric patients with severe combined immune deficiency (SCID): pre- and post-hematopoietic stem cell transplant (HSCT).
Journal of clinical immunology 2009;29(2):231-7.
2009: Shah Ami J; Kapoor Neena; Cooper Robert M; Crooks Gay M; Lenarsky Carl; Abdel-Azim Hisham; Wu Shi Qi; Wilson Kathy; Weinberg Kenneth I; Parkman Robertson; Kohn Donald B
Pre- and post-natal treatment of hemophagocytic lymphohistiocytosis.
Pediatric blood & cancer 2009;52(1):139-42.
2008: Bauer Gerhard; Dao Mo A; Case Scott S; Meyerrose Todd; Wirthlin Louisa; Zhou Ping; Wang Xiuli; Herrbrich Phillip; Arevalo Jesusa; Csik Susie; Skelton Dianne C; Walker Jon; Pepper Karen; Kohn Donald B; Nolta Jan A
In vivo biosafety model to assess the risk of adverse events from retroviral and lentiviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(7):1308-15.
2008: Shah Ami J; Epport Karen; Azen Colleen; Killen Renna; Wilson Kathy; De Clerck Dominique; Crooks Gay; Kapoor Neena; Kohn Donald B; Parkman Robertson; Weinberg Kenneth I
Progressive declines in neurocognitive function among survivors of hematopoietic stem cell transplantation for pediatric hematologic malignancies.
Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology 2008;30(6):411-8.
2008: Carbonaro Denise A; Jin Xiangyang; Cotoi Daniel; Mi Tiejuan; Yu Xiao-Jin; Skelton Dianne C; Dorey Frederick; Kellems Rodney E; Blackburn Michael R; Kohn Donald B
Neonatal bone marrow transplantation of ADA-deficient SCID mice results in immunologic reconstitution despite low levels of engraftment and an absence of selective donor T lymphoid expansion.
Blood 2008;111(12):5745-54.
2008: Abdel-Azim Hisham; Zhu Yuhua; Hollis Roger; Wang Xiuli; Ge Shundi; Hao Qian-Lin; Smbatyan Goar; Kohn Donald B; Rosol Michael; Crooks Gay M
Expansion of multipotent and lymphoid-committed human progenitors through intracellular dimerization of Mpl.
Blood 2008;111(8):4064-74.
2008: Taylor Jason A; Vojtech Lucia; Bahner Ingrid; Kohn Donald B; Laer Dorothee Von; Russell David W; Richard Robert E
Foamy virus vectors expressing anti-HIV transgenes efficiently block HIV-1 replication.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(1):46-51.
2007: Rodriguez Ryan T; Velkey J Matthew; Lutzko Carolyn; Seerke Rina; Kohn Donald B; O'Shea K Sue; Firpo Meri T
Manipulation of OCT4 levels in human embryonic stem cells results in induction of differential cell types.
Experimental biology and medicine (Maywood, N.J.) 2007;232(10):1368-80.
2007: Higashimoto T; Urbinati F; Perumbeti A; Jiang G; Zarzuela A; Chang L-J; Kohn D B; Malik P
The woodchuck hepatitis virus post-transcriptional regulatory element reduces readthrough transcription from retroviral vectors.
Gene therapy 2007;14(17):1298-304.
2007: Shah Ami J; Kapoor Neena; Crooks Gay M; Weinberg Kenneth I; Azim Hisham Abdel; Killen Renna; Kuo Lily; Rushing Teresa; Kohn Donald B; Parkman Robertson
The effects of Campath 1H upon graft-versus-host disease, infection, relapse, and immune reconstitution in recipients of pediatric unrelated transplants.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2007;13(5):584-93.
2007: Blumenthal Martina; Skelton Dianne; Pepper Karen A; Jahn Thomas; Methangkool Emily; Kohn Donald B
Effective suicide gene therapy for leukemia in a model of insertional oncogenesis in mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(1):183-92.
2007: Bahner Ingrid; Sumiyoshi Teiko; Kagoda Mercy; Swartout Robin; Peterson Denise; Pepper Karen; Dorey Fred; Reiser Jacob; Kohn Donald B
Lentiviral vector transduction of a dominant-negative Rev gene into human CD34+ hematopoietic progenitor cells potently inhibits human immunodeficiency virus-1 replication.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(1):76-85.
2007: Engel Barbara C; Podsakoff Greg M; Ireland Joanna L; Smogorzewska E Monika; Carbonaro Denise A; Wilson Kathy; Shah Ami; Kapoor Neena; Sweeney Mirna; Borchert Mark; Crooks Gay M; Weinberg Kenneth I; Parkman Robertson; Rosenblatt Howard M; Wu Shi-Qi; Hershfield Michael S; Candotti Fabio; Kohn Donald B
Prolonged pancytopenia in a gene therapy patient with ADA-deficient SCID and trisomy 8 mosaicism: a case report.
Blood 2007;109(2):503-6.
2007: Fischer-Lougheed J Y; Tarantal A F; Shulkin I; Mitsuhashi N; Kohn D B; Lee C C I; Kearns-Jonker M
Gene therapy to inhibit xenoantibody production using lentiviral vectors in non-human primates.
Gene therapy 2007;14(1):49-57.
2006: Hollis Roger P; Nightingale Sarah J; Wang Xiuli; Pepper Karen A; Yu Xiao-Jin; Barsky Lora; Crooks Gay M; Kohn Donald B
Stable gene transfer to human CD34(+) hematopoietic cells using the Sleeping Beauty transposon.
Experimental hematology 2006;34(10):1333-43.
2006: Carbonaro Denise A; Jin Xiangyang; Petersen Denise; Wang Xingchao; Dorey Fred; Kil Ki Soo; Aldrich Melissa; Blackburn Michael R; Kellems Rodney E; Kohn Donald B
In vivo transduction by intravenous injection of a lentiviral vector expressing human ADA into neonatal ADA gene knockout mice: a novel form of enzyme replacement therapy for ADA deficiency.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(6):1110-20.
2006: Nightingale Sarah J; Hollis Roger P; Pepper Karen A; Petersen Denise; Yu Xiao-Jin; Yang Catherine; Bahner Ingrid; Kohn Donald B
Transient gene expression by nonintegrating lentiviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(6):1121-32.
2006: Kahl Christoph A; Tarantal Alice F; Lee Chang I; Jimenez Daniel F; Choi Christopher; Pepper Karen; Petersen Denise; Fletcher Misty D; Leapley Alyssa C; Fisher Jennifer; Burns Travis S; Ultsch Man-Ni; Dorey Frederick J; Kohn Donald B
Effects of busulfan dose escalation on engraftment of infant rhesus monkey hematopoietic stem cells after gene marking by a lentiviral vector.
Experimental hematology 2006;34(3):369-81.
2006: Mitsuhashi Noboru; Fischer-Lougheed Jacqueline; Shulkin Irina; Kleihauer Annette; Kohn Donald B; Weinberg Kenneth I; Starnes Vaughn A; Kearns-Jonker Mary
Tolerance induction by lentiviral gene therapy with a nonmyeloablative regimen.
Blood 2006;107(6):2286-93.
2006: Jang Jung-Eun; Shaw Kit; Yu Xiao-Jin; Petersen Denise; Pepper Karen; Lutzko Carolyn; Kohn Donald B
Specific and stable gene transfer to human embryonic stem cells using pseudotyped lentiviral vectors.
Stem cells and development 2006;15(1):109-17.
2005: Podsakoff Greg M; Engel Barbara C; Kohn Donald B
Perspectives on gene therapy for immune deficiencies.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2005;11(12):972-6.
2005: Chan Belinda; Wara Diane; Bastian John; Hershfield Michael S; Bohnsack John; Azen Colleen G; Parkman Robertson; Weinberg Kenneth; Kohn Donald B
Long-term efficacy of enzyme replacement therapy for adenosine deaminase (ADA)-deficient severe combined immunodeficiency (SCID).
Clinical immunology (Orlando, Fla.) 2005;117(2):133-43.
2005: Shah Ami J; Kapoor Neena; Crooks Gay M; Parkman Robertson; Weinberg Kenneth I; Wilson Kathy; Kohn Donald B
Successful hematopoietic stem cell transplantation for Niemann-Pick disease type B.
Pediatrics 2005;116(4):1022-5.
2005: Gruber Tanja A; Skelton Dianne C; Kohn Donald B
Recombinant murine interleukin-12 elicits potent antileukemic immune responses in a murine model of Philadelphia chromosome-positive acute lymphoblastic leukemia.
Cancer gene therapy 2005;12(10):818-24.
2005: Tarantal Alice F; McDonald Ruth J; Jimenez Daniel F; Lee C Chang I; O'Shea Cristin E; Leapley Alyssa C; Won Rosa H; Plopper Charles G; Lutzko Carolyn; Kohn Donald B
Intrapulmonary and intramyocardial gene transfer in rhesus monkeys (Macaca mulatta): safety and efficiency of HIV-1-derived lentiviral vectors for fetal gene delivery.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(1):87-98.
2005: Podsakoff Greg M; Engel Barbara C; Carbonaro Denise A; Choi Chris; Smogorzewska Elzbieta M; Bauer Gerhard; Selander David; Csik Susan; Wilson Kathy; Betts Michael R; Koup Richard A; Nabel Gary J; Bishop Keith; King Steven; Schmidt Manfred; von Kalle Christof; Church Joseph A; Kohn Donald B
Selective survival of peripheral blood lymphocytes in children with HIV-1 following delivery of an anti-HIV gene to bone marrow CD34(+) cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(1):77-86.
2005: Kobayashi Hiroshi; Carbonaro Denise; Pepper Karen; Petersen Denise; Ge Shundi; Jackson Holly; Shimada Hiroyuki; Moats Rex; Kohn Donald B
Neonatal gene therapy of MPS I mice by intravenous injection of a lentiviral vector.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;11(5):776-89.
2005: Jimenez D F; Lee C I; O'Shea C E; Kohn D B; Tarantal A F
HIV-1-derived lentiviral vectors and fetal route of administration on transgene biodistribution and expression in rhesus monkeys.
Gene therapy 2005;12(10):821-30.
2005: Lee C Chang I; Jimenez Daniel F; Kohn Donald B; Tarantal Alice F
Fetal gene transfer using lentiviral vectors and the potential for germ cell transduction in rhesus monkeys (Macaca mulatta).
Human gene therapy 2005;16(4):417-25.
2004: Logan Aaron C; Nightingale Sarah J; Haas Dennis L; Cho Gerald J; Pepper Karen A; Kohn Donald B
Factors influencing the titer and infectivity of lentiviral vectors.
Human gene therapy 2004;15(10):976-88.
2004: Logan Aaron C; Haas Dennis L; Kafri Tal; Kohn Donald B
Integrated self-inactivating lentiviral vectors produce full-length genomic transcripts competent for encapsidation and integration.
Journal of virology 2004;78(16):8421-36.
2004: Kearns-Jonker Mary; Fischer-Lougheed Jacqueline; Shulkin Irina; Kleihauer Annette; Mitsuhashi Noboru; Kohn Donald B; Weinberg Kenneth; D'Apice Anthony J F; Starnes Vaughn A; Cramer Donald V
Use of lentiviral vectors to induce long-term tolerance to gal(+) heart grafts.
Transplantation 2004;77(11):1748-54.
2004: Lee Chang I; Cowan Morton J; Kohn Donald B; Tarantal Alice F
Simian immunodeficiency virus infection of hematopoietic stem cells and bone marrow stromal cells.
Journal of acquired immune deficiency syndromes (1999) 2004;36(1):553-61.
2004: Shah Ami J; Lenarsky Carl; Kapoor Neena; Crooks Gay M; Kohn Donald B; Parkman Robertson; Epport Karen; Wilson Kathy; Weinberg Ken
Busulfan and cyclophosphamide as a conditioning regimen for pediatric acute lymphoblastic leukemia patients undergoing bone marrow transplantation.
Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology 2004;26(2):91-7.
2004: Lee Chang I; Kohn Donald B; Ekert Jason E; Tarantal Alice F
Morphological analysis and lentiviral transduction of fetal monkey bone marrow-derived mesenchymal stem cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;9(1):112-23.
2003: Wang Xiuli; Rosol Michael; Ge Shundi; Peterson Denise; McNamara George; Pollack Harvey; Kohn Donald B; Nelson Marvin D; Crooks Gay M
Dynamic tracking of human hematopoietic stem cell engraftment using in vivo bioluminescence imaging.
Blood 2003;102(10):3478-82.
2003: Engel Barbara C; Kohn Donald B; Podsakoff Greg M
Update on gene therapy of inherited immune deficiencies.
Current opinion in molecular therapeutics 2003;5(5):503-7.
2003: Goto Hiroaki; Yang Bo; Petersen Denise; Pepper Karen A; Alfaro Paul A; Kohn Donald B; Reynolds C Patrick
Transduction of green fluorescent protein increased oxidative stress and enhanced sensitivity to cytotoxic drugs in neuroblastoma cell lines.
Molecular cancer therapeutics 2003;2(9):911-7.
2003: Haas Dennis L; Lutzko Carolyn; Logan Aaron C; Cho Gerald J; Skelton Dianne; Jin Yu Xiao; Pepper Karen A; Kohn Donald B
The Moloney murine leukemia virus repressor binding site represses expression in murine and human hematopoietic stem cells.
Journal of virology 2003;77(17):9439-50.
2003: Kohn Donald B; Sadelain Michel; Glorioso Joseph C
Occurrence of leukaemia following gene therapy of X-linked SCID.
Nature reviews. Cancer 2003;3(7):477-88.
2003: Lutzko Carolyn; Senadheera Dinithi; Skelton Dianne; Petersen Denise; Kohn Donald B
Lentivirus vectors incorporating the immunoglobulin heavy chain enhancer and matrix attachment regions provide position-independent expression in B lymphocytes.
Journal of virology 2003;77(13):7341-51.
2003: Burgos J S; Rosol M; Moats R A; Khankaldyyan V; Kohn D B; Nelson M D; Laug W E
Time course of bioluminescent signal in orthotopic and heterotopic brain tumors in nude mice.
BioTechniques 2003;34(6):1184-8.
2003: Schmidt Manfred; Glimm Hanno; Wissler Manuela; Hoffmann Gesa; Olsson Karin; Sellers Stephanie; Carbonaro Denise; Tisdale John F; Leurs Cordula; Hanenberg Helmut; Dunbar Cynthia E; Kiem Hans-Peter; Karlsson Stefan; Kohn Donald B; Williams David; Von Kalle Christof
Efficient characterization of retro-, lenti-, and foamyvector-transduced cell populations by high-accuracy insertion site sequencing.
Annals of the New York Academy of Sciences 2003;996():112-21.
2003: Wang Lijun; Haas Dennis; Halene Stephanie; Kohn Donald B
Effects of the negative control region on expression from retroviral LTR.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;7(4):438-40.
2003: Schmidt Manfred; Carbonaro Denise A; Speckmann Carsten; Wissler Manuela; Bohnsack John; Elder Melissa; Aronow Bruce J; Nolta Jan A; Kohn Donald B; von Kalle Christof
Clonality analysis after retroviral-mediated gene transfer to CD34+ cells from the cord blood of ADA-deficient SCID neonates.
Nature medicine 2003;9(4):463-8.
2003: Smogorzewska Elzbieta Monika; Weinberg Kenneth I; Kohn Donald B
[Transplantation of genetically modified cells in the treatment of children with SCID: great hopes and recent disappointments]
Medycyna wieku rozwojowego 2003;7(1):27-34.
2003: Engel Barbara C; Kohn Donald B
Gene therapy for inborn and acquired immune deficiency disorders.
Acta haematologica 2003;110(2-3):60-70.
2002: Grove Joanna E; Lutzko Carolyn; Priller Josef; Henegariu Octavian; Theise Neil D; Kohn Donald B; Krause Diane S
Marrow-derived cells as vehicles for delivery of gene therapy to pulmonary epithelium.
American journal of respiratory cell and molecular biology 2002;27(6):645-51.
2002: Price Mary A; Case Scott S; Carbonaro Denise A; Yu Xiao-Jin; Petersen Denise; Sabo Kathleen M; Curran Michael A; Engel Barbara C; Margarian Hovanes; Abkowitz Janis L; Nolan Garry P; Kohn Donald B; Crooks Gay M
Expression from second-generation feline immunodeficiency virus vectors is impaired in human hematopoietic cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(5):645-52.
2002: Logan Aaron C; Lutzko Carolyn; Kohn Donald B
Advances in lentiviral vector design for gene-modification of hematopoietic stem cells.
Current opinion in biotechnology 2002;13(5):429-36.
2002: Kohn Donald B
Adenosine deaminase gene therapy protocol revisited.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(2):96-7.
2002: O'Rourke J P; Newbound G C; Kohn D B; Olsen J C; Bunnell B A
Comparison of gene transfer efficiencies and gene expression levels achieved with equine infectious anemia virus- and human immunodeficiency virus type 1-derived lentivirus vectors.
Journal of virology 2002;76(3):1510-5.
2002: Gruber Tanja A; Skelton Dianne C; Kohn Donald B
Requirement for NK cells in CD40 ligand-mediated rejection of Philadelphia chromosome-positive acute lymphoblastic leukemia cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(1):73-80.
2002: Shah Ami J; Kapoor Neena; Weinberg Kenneth I; Crooks Gay M; Kohn Donald B; Lenarsky Carl; Kaufman Francine; Epport Karen; Wilson Kathy; Parkman Robertson
Second hematopoietic stem cell transplantation in pediatric patients: overall survival and long-term follow-up.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2002;8(4):221-8.
2001: Skelton D; Satake N; Kohn D B
The enhanced green fluorescent protein (eGFP) is minimally immunogenic in C57BL/6 mice.
Gene therapy 2001;8(23):1813-4.
2001: Tarantal A F; Lee C I; Ekert J E; McDonald R; Kohn D B; Plopper C G; Case S S; Bunnell B A
Lentiviral vector gene transfer into fetal rhesus monkeys (Macaca mulatta): lung-targeting approaches.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;4(6):614-21.
2001: Weinberg K I; Kapoor N; Shah A J; Crooks G M; Kohn D B; Parkman R
Hematopoietic stem cell transplantation for severe combined immune deficiency.
Current allergy and asthma reports 2001;1(5):416-20.
2001: Kohn D B
Gene therapy for genetic haematological disorders and immunodeficiencies.
Journal of internal medicine 2001;249(4):379-90.
2001: Tarantal A F; O'Rourke J P; Case S S; Newbound G C; Li J; Lee C I; Baskin C R; Kohn D B; Bunnell B A
Rhesus monkey model for fetal gene transfer: studies with retroviral- based vector systems.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;3(2):128-38.
2000: Bauer G; Selander D; Engel B; Carbonaro D; Csik S; Rawlings S; Church J; Kohn D B
Gene therapy for pediatric AIDS.
Annals of the New York Academy of Sciences 2000;918():318-29.
2000: Stripecke R; Cardoso A A; Pepper K A; Skelton D C; Yu X J; Mascarenhas L; Weinberg K I; Nadler L M; Kohn D B
Lentiviral vectors for efficient delivery of CD80 and granulocyte-macrophage- colony-stimulating factor in human acute lymphoblastic leukemia and acute myeloid leukemia cells to induce antileukemic immune responses.
Blood 2000;96(4):1317-26.
2000: Haas D L; Case S S; Crooks G M; Kohn D B
Critical factors influencing stable transduction of human CD34(+) cells with HIV-1-derived lentiviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;2(1):71-80.
2000: Halene S; Kohn D B
Gene therapy using hematopoietic stem cells: Sisyphus approaches the crest.
Human gene therapy 2000;11(9):1259-67.
2000: Engel B C; Bauer G; Pepper K A; Bockstoce D C; Yu X J; Chen S Y; Kohn D B
Intrakines--evidence for a trans-cellular mechanism of action.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;1(2):165-70.
2000: Huang M M; Tsuboi S; Wong A; Yu X J; Oh-Eda M; Derry J M; Francke U; Fukuda M; Weinberg K I; Kohn D B
Expression of human Wiskott-Aldrich syndrome protein in patients' cells leads to partial correction of a phenotypic abnormality of cell surface glycoproteins.
Gene therapy 2000;7(4):314-20.
2000: Smogorzewska E M; Brooks J; Annett G; Kapoor N; Crooks G M; Kohn D B; Parkman R; Weinberg K I
T cell depleted haploidentical bone marrow transplantation for the treatment of children with severe combined immunodeficiency.
Archivum immunologiae et therapiae experimentalis 2000;48(2):111-8.
1999: Halene S; Wang L; Cooper R M; Bockstoce D C; Robbins P B; Kohn D B
Improved expression in hematopoietic and lymphoid cells in mice after transplantation of bone marrow transduced with a modified retroviral vector.
Blood 1999;94(10):3349-57.
1999: Stripecke R; Skelton D C; Pattengale P K; Shimada H; Kohn D B
Combination of CD80 and granulocyte-macrophage colony-stimulating factor coexpression by a leukemia cell vaccine: preclinical studies in a murine model recapitulating Philadelphia chromosome-positive acute lymphoblastic leukemia.
Human gene therapy 1999;10(13):2109-22.
1999: Kohn D B
Gene therapy using hematopoietic stem cells.
Current opinion in molecular therapeutics 1999;1(4):437-42.
1999: Crooks G M; Fuller J; Petersen D; Izadi P; Malik P; Pattengale P K; Kohn D B; Gasson J C
Constitutive HOXA5 expression inhibits erythropoiesis and increases myelopoiesis from human hematopoietic progenitors.
Blood 1999;94(2):519-28.
1999: Kohn D B; Bauer G; Rice C R; Rothschild J C; Carbonaro D A; Valdez P; Hao Q l; Zhou C; Bahner I; Kearns K; Brody K; Fox S; Haden E; Wilson K; Salata C; Dolan C; Wetter C; Aguilar-Cordova E; Church J
A clinical trial of retroviral-mediated transfer of a rev-responsive element decoy gene into CD34(+) cells from the bone marrow of human immunodeficiency virus-1-infected children.
Blood 1999;94(1):368-71.
1999: Case S S; Price M A; Jordan C T; Yu X J; Wang L; Bauer G; Haas D L; Xu D; Stripecke R; Naldini L; Kohn D B; Crooks G M
Stable transduction of quiescent CD34(+)CD38(-) human hematopoietic cells by HIV-1-based lentiviral vectors.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):2988-93.
1998: Dunbar C E; Kohn D B; Schiffmann R; Barton N W; Nolta J A; Esplin J A; Pensiero M; Long Z; Lockey C; Emmons R V; Csik S; Leitman S; Krebs C B; Carter C; Brady R O; Karlsson S
Retroviral transfer of the glucocerebrosidase gene into CD34+ cells from patients with Gaucher disease: in vivo detection of transduced cells without myeloablation.
Human gene therapy 1998;9(17):2629-40.
1998: Wang L; Robbins P B; Carbonaro D A; Kohn D B
High-resolution analysis of cytosine methylation in the 5long terminal repeat of retroviral vectors.
Human gene therapy 1998;9(16):2321-30.
1998: Mascarenhas L; Stripecke R; Case S S; Xu D; Weinberg K I; Kohn D B
Gene delivery to human B-precursor acute lymphoblastic leukemia cells.
Blood 1998;92(10):3537-45.
1998: Weinberg K I; Kohn D B
Gene therapy for congenital lymphoid immunodeficiency diseases.
Seminars in hematology 1998;35(4):354-66.
1998: Kapoor N; Crooks G; Kohn D B; Parkman R
Hematopoietic stem cell transplantation for primary lymphoid immunodeficiencies.
Seminars in hematology 1998;35(4):346-53.
1998: Stripecke R; Skelton D C; Gruber T; Afar D; Pattengale P K; Witte O N; Kohn D B
Immune response to Philadelphia chromosome-positive acute lymphoblastic leukemia induced by expression of CD80, interleukin 2, and granulocyte-macrophage colony-stimulating factor.
Human gene therapy 1998;9(14):2049-62.
1998: Robbins P B; Skelton D C; Yu X J; Halene S; Leonard E H; Kohn D B
Consistent, persistent expression from modified retroviral vectors in murine hematopoietic stem cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(17):10182-7.
1998: Kohn D B; Hershfield M S; Carbonaro D; Shigeoka A; Brooks J; Smogorzewska E M; Barsky L W; Chan R; Burotto F; Annett G; Nolta J A; Crooks G; Kapoor N; Elder M; Wara D; Bowen T; Madsen E; Snyder F F; Bastian J; Muul L; Blaese R M; Weinberg K; Parkman R
T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34+ cells in ADA-deficient SCID neonates.
Nature medicine 1998;4(7):775-80.
1998: Verma S; Woffendin C; Bahner I; Ranga U; Xu L; Yang Z Y; King S R; Kohn D B; Nabel G J
Gene transfer into human umbilical cord blood-derived CD34+ cells by particle-mediated gene transfer.
Gene therapy 1998;5(5):692-9.
1998: Malik P; Fisher T C; Barsky L L; Zeng L; Izadi P; Hiti A L; Weinberg K I; Coates T D; Meiselman H J; Kohn D B
An in vitro model of human red blood cell production from hematopoietic progenitor cells.
Blood 1998;91(8):2664-71.
1998: Bauer G; Sauter S; Ibanez C; Rice C R; Valdez P; Jolly D; Kohn D B
Increased gene transfer into human CD34+ progenitor cells using retroviral vectors produced by a canine packaging cell line.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 1998;4(3):119-27.
1997: Robbins P B; Yu X J; Skelton D M; Pepper K A; Wasserman R M; Zhu L; Kohn D B
Increased probability of expression from modified retroviral vectors in embryonal stem cells and embryonal carcinoma cells.
Journal of virology 1997;71(12):9466-74.
1997: Huang M M; Wong A; Yu X; Kakkis E; Kohn D B
Retrovirus-mediated transfer of the human alpha-L-iduronidase cDNA into human hematopoietic progenitor cells leads to correction in trans of Hurler fibroblasts.
Gene therapy 1997;4(11):1150-9.
1997: Bahner I; Kearns K; Coutinho S; Leonard E H; Kohn D B
Infection of human marrow stroma by human immunodeficiency virus-1 (HIV-1) is both required and sufficient for HIV-1-induced hematopoietic suppression in vitro: demonstration by gene modification of primary human stroma.
Blood 1997;90(5):1787-98.
1997: Kohn D B; Parkman R
Gene therapy for newborns.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1997;11(8):635-9.
1997: Bauer G; Valdez P; Kearns K; Bahner I; Wen S F; Zaia J A; Kohn D B
Inhibition of human immunodeficiency virus-1 (HIV-1) replication after transduction of granulocyte colony-stimulating factor-mobilized CD34+ cells from HIV-1-infected donors using retroviral vectors containing anti-HIV-1 genes.
Blood 1997;89(7):2259-67.
1997: Malik P; McQuiston S A; Yu X J; Pepper K A; Krall W J; Podsakoff G M; Kurtzman G J; Kohn D B
Recombinant adeno-associated virus mediates a high level of gene transfer but less efficient integration in the K562 human hematopoietic cell line.
Journal of virology 1997;71(3):1776-83.
1997: Kearns K; Bahner I; Bauer G; Wei S F; Valdez P; Wheeler S; Woods L; Miller R; Casciato D; Galpin J; Church J; Kohn D B
Suitability of bone marrow from HIV-1-infected donors for retrovirus-mediated gene transfer.
Human gene therapy 1997;8(3):301-11.
1997: Kohn D B
Gene therapy for haematopoietic and lymphoid disorders.
Clinical and experimental immunology 1997;107 Suppl 1():54-7.
1997: Dao M A; Hannum C H; Kohn D B; Nolta J A
FLT3 ligand preserves the ability of human CD34+ progenitors to sustain long-term hematopoiesis in immune-deficient mice after ex vivo retroviral-mediated transduction.
Blood 1997;89(2):446-56.
1996: Kohn D B
Gene therapy for hematopoietic and immune disorders.
Bone marrow transplantation 1996;18 Suppl 3():S55-8.
1996: Taylor N; Bacon K B; Smith S; Jahn T; Kadlecek T A; Uribe L; Kohn D B; Gelfand E W; Weiss A; Weinberg K
Reconstitution of T cell receptor signaling in ZAP-70-deficient cells by retroviral transduction of the ZAP-70 gene.
The Journal of experimental medicine 1996;184(5):2031-6.
1996: Shull R M; Lu X; McEntee M F; Bright R M; Pepper K A; Kohn D B
Myoblast gene therapy in canine mucopolysaccharidosis. I: Abrogation by an immune response to alpha-L-iduronidase.
Human gene therapy 1996;7(13):1595-603.
1996: Bahner I; Kearns K; Hao Q L; Smogorzewska E M; Kohn D B
Transduction of human CD34+ hematopoietic progenitor cells by a retroviral vector expressing an RRE decoy inhibits human immunodeficiency virus type 1 replication in myelomonocytic cells produced in long-term culture.
Journal of virology 1996;70(7):4352-60.
1996: Jadus M R; Irwin M C; Irwin M R; Horansky R D; Sekhon S; Pepper K A; Kohn D B; Wepsic H T
Macrophages can recognize and kill tumor cells bearing the membrane isoform of macrophage colony-stimulating factor.
Blood 1996;87(12):5232-41.
1996: Krall W; Kohn D B
Expression levels by retroviral vectors based upon the N2 and the MFG backbones.
Gene therapy 1996;3(4):365.
1996: Taylor N; Uribe L; Smith S; Jahn T; Kohn D B; Weinberg K
Correction of interleukin-2 receptor function in X-SCID lymphoblastoid cells by retrovirally mediated transfer of the gamma-c gene.
Blood 1996;87(8):3103-7.
1996: Nolta J A; Dao M A; Wells S; Smogorzewska E M; Kohn D B
Transduction of pluripotent human hematopoietic stem cells demonstrated by clonal analysis after engraftment in immune-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(6):2414-9.
1996: Krall W J; Skelton D C; Yu X J; Riviere I; Lehn P; Mulligan R C; Kohn D B
Increased levels of spliced RNA account for augmented expression from the MFG retroviral vector in hematopoietic cells.
Gene therapy 1996;3(1):37-48.
1996: Zhou C; Bahner I; Rossi J J; Kohn D B
Expression of hammerhead ribozymes by retroviral vectors to inhibit HIV-1 replication: comparison of RNA levels and viral inhibition.
Antisense & nucleic acid drug development 1996;6(1):17-24.
1995: Wells S; Malik P; Pensiero M; Kohn D B; Nolta J A
The presence of an autologous marrow stromal cell layer increases glucocerebrosidase gene transduction of long-term culture initiating cells (LTCICs) from the bone marrow of a patient with Gaucher disease.
Gene therapy 1995;2(8):512-20.
1995: Malik P; Krall W J; Yu X J; Zhou C; Kohn D B
Retroviral-mediated gene expression in human myelomonocytic cells: a comparison of hematopoietic cell promoters to viral promoters.
Blood 1995;86(8):2993-3005.
1995: Kohn D B; Weinberg K I; Nolta J A; Heiss L N; Lenarsky C; Crooks G M; Hanley M E; Annett G; Brooks J S; el-Khoureiy A
Engraftment of gene-modified umbilical cord blood cells in neonates with adenosine deaminase deficiency.
Nature medicine 1995;1(10):1017-23.
1995: Nolta J A; Smogorzewska E M; Kohn D B
Analysis of optimal conditions for retroviral-mediated transduction of primitive human hematopoietic cells.
Blood 1995;86(1):101-10.
1995: Hao Q L; Malik P; Salazar R; Tang H; Gordon E M; Kohn D B
Expression of biologically active human factor IX in human hematopoietic cells after retroviral vector-mediated gene transduction.
Human gene therapy 1995;6(7):873-80.
1995: Challita P M; Skelton D; el-Khoueiry A; Yu X J; Weinberg K; Kohn D B
Multiple modifications in cis elements of the long terminal repeat of retroviral vectors lead to increased expression and decreased DNA methylation in embryonic carcinoma cells.
Journal of virology 1995;69(2):748-55.
1995: Kohn D B
The current status of gene therapy using hematopoietic stem cells.
Current opinion in pediatrics 1995;7(1):56-63.
1995: Parkman R; Crooks G; Kohn D B; Lenarsky C; Weinberg K
Bone marrow transplantation for metabolic diseases.
Cancer treatment and research 1995;76():87-96.
1994: Krall W J; Challita P M; Perlmutter L S; Skelton D C; Kohn D B
Cells expressing human glucocerebrosidase from a retroviral vector repopulate macrophages and central nervous system microglia after murine bone marrow transplantation.
Blood 1994;83(9):2737-48.
1994: Nolta J A; Hanley M B; Kohn D B
Sustained human hematopoiesis in immunodeficient mice by cotransplantation of marrow stroma expressing human interleukin-3: analysis of gene transduction of long-lived progenitors.
Blood 1994;83(10):3041-51.
1994: Challita P M; Kohn D B
Lack of expression from a retroviral vector after transduction of murine hematopoietic stem cells is associated with methylation in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(7):2567-71.
1994: Hanley M E; Nolta J A; Parkman R; Kohn D B
Umbilical cord blood cell transduction by retroviral vectors: preclinical studies to optimize gene transfer.
Blood cells 1994;20(2-3):539-43; discussion 544-6.
1993: Crooks G M; Kohn D B
Growth factors increase amphotropic retrovirus binding to human CD34+ bone marrow progenitor cells.
Blood 1993;82(11):3290-7.
1993: Lenarsky C; Weinberg K; Kohn D B; Parkman R
Unrelated donor BMT for Wiskott-Aldrich syndrome.
Bone marrow transplantation 1993;12(2):145-7.
1993: Roberts W D; Weinberg K I; Kohn D B; Sender L; Parkman R; Lenarsky C
Granulocyte recovery in pediatric marrow transplant recipients treated with ganciclovir for cytomegalovirus infection.
The American journal of pediatric hematology/oncology 1993;15(3):320-3.
1993: Bahner I; Zhou C; Yu X J; Hao Q L; Guatelli J C; Kohn D B
Comparison of trans-dominant inhibitory mutant human immunodeficiency virus type 1 genes expressed by retroviral vectors in human T lymphocytes.
Journal of virology 1993;67(6):3199-207.
1992: Nolta J A; Crooks G M; Overell R W; Williams D E; Kohn D B
Retroviral vector-mediated gene transfer into primitive human hematopoietic progenitor cells: effects of mast cell growth factor (MGF) combined with other cytokines.
Experimental hematology 1992;20(9):1065-71.
1992: Nolta J A; Yu X J; Bahner I; Kohn D B
Retroviral-mediated transfer of the human glucocerebrosidase gene into cultured Gaucher bone marrow.
The Journal of clinical investigation 1992;90(2):342-8.
1992: Bedgood R M; Bahner I; Kohn D B; Stallcup M R
Two different genes coding for processable and nonprocessable forms of a viral envelope protein can account for the apparent hormonal stimulation of protein processing in W7MG1 lymphoma cells.
Molecular endocrinology (Baltimore, Md.) 1992;6(3):459-67.
1991: Weinthal J; Nolta J A; Yu X J; Lilley J; Uribe L; Kohn D B
Expression of human glucocerebrosidase following retroviral vector-mediated transduction of murine hematopoietic stem cells.
Bone marrow transplantation 1991;8(5):403-12.
1991: Kohn D B; Nolta J A; Weinthal J; Bahner I; Yu X J; Lilley J; Crooks G M
Toward gene therapy for Gaucher disease.
Human gene therapy 1991;2(2):101-5.
1990: Lenarsky C; Kohn D B; Weinberg K I; Parkman R
Bone marrow transplantation for genetic diseases.
Hematology/oncology clinics of North America 1990;4(3):589-602.
1990: Nolta J A; Sender L S; Barranger J A; Kohn D B
Expression of human glucocerebrosidase in murine long-term bone marrow cultures after retroviral vector-mediated transfer.
Blood 1990;75(3):787-97.
1990: Nolta J A; Kohn D B
Comparison of the effects of growth factors on retroviral vector-mediated gene transfer and the proliferative status of human hematopoietic progenitor cells.
Human gene therapy 1990;1(3):257-68.
1989: Kohn D B; Mitsuya H; Ballow M; Selegue J E; Barankiewicz J; Cohen A; Gelfand E; Anderson W F; Blaese R M
Establishment and characterization of adenosine deaminase-deficient human T cell lines.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(11):3971-7.
1989: Kohn D B; Anderson W F; Blaese R M
Gene therapy for genetic diseases.
Cancer investigation 1989;7(2):179-92.
1988: Eglitis M A; Kohn D B; Moen R C; Blaese R M; Anderson W F
Infection of human hematopoietic progenitor cells using a retroviral vector with a xenotropic pseudotype.
Biochemical and biophysical research communications 1988;151(1):201-6.
1988: Eglitis M A; Kantoff P W; Kohn D B; Karson E; Moen R C; Lothrop C D; Blaese R M; Anderson W F
Retroviral-mediated gene transfer into hemopoietic cells.
Advances in experimental medicine and biology 1988;241():19-27.
1987: Kantoff P W; Gillio A P; McLachlin J R; Bordignon C; Eglitis M A; Kernan N A; Moen R C; Kohn D B; Yu S F; Karson E
Expression of human adenosine deaminase in nonhuman primates after retrovirus-mediated gene transfer.
The Journal of experimental medicine 1987;166(1):219-34.
1987: Eglitis M A; Kantoff P W; McLachlin J R; Gillio A; Flake A W; Bordignon C; Moen R C; Karson E M; Zwiebel J A; Kohn D B
Gene therapy: efforts at developing large animal models for autologous bone marrow transplant and gene transfer with retroviral vectors.
Ciba Foundation symposium 1987;130():229-46.
1987: Kohn D B; Kantoff P W; Eglitis M A; McLachlin J R; Moen R C; Karson E; Zwiebel J A; Nienhuis A; Karlsson S; O'Reilly R
Retroviral-mediated gene transfer into mammalian cells.
Blood cells 1987;13(1-2):285-98.
1986: Kantoff P W; Kohn D B; Mitsuya H; Armentano D; Sieberg M; Zwiebel J A; Eglitis M A; McLachlin J R; Wiginton D A; Hutton J J
Correction of adenosine deaminase deficiency in cultured human T and B cells by retrovirus-mediated gene transfer.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(17):6563-7.
1986: Kantoff P W; Gillio A; McLachlin J R; Flake A W; Eglitis M A; Moen R; Karlsson S; Kohn D B; Karson E; Zwiebel J A
Retroviral-mediated gene transfer into hematopoietic cells.
Transactions of the Association of American Physicians 1986;99():92-102.

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