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Leonard Kohn
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30
Suzuki, Koichi
23
singer, dinah
17
Napolitano, Giorgio
15
Giuliani, Cesidio
15
Kosugi, Shinji
14
Grollman, Evelyn
10
Nakazato, Minoru
10
Saji, Motoyasu
9
Ulianich, Luca
8
Prabhakar, Bellur
8
Mori, A
7
Pietrarelli, M
7
Vitti, Paolo
7
Yavin, Ephraim
6
Green, Eric
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All Publications
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2009: Schwartz Anthony L; Malgor Ramiro; Dickerson Eric; Weeraratna Ashani T; Slominski Andrzej; Wortsman Jacobo; Harii Norikazu; Kohn Aimee D; Moon Randall T; Schwartz Frank L; Goetz Douglas J; Kohn Leonard D; McCall Kelly D
Phenylmethimazole decreases Toll-like receptor 3 and noncanonical Wnt5a expression in pancreatic cancer and melanoma together with tumor cell growth and migration.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(12):4114-22.
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2008: Deosarkar Sudhir P; Malgor Ramiro; Fu Jie; Kohn Leonard D; Hanes Justin; Goetz Douglas J
Polymeric particles conjugated with a ligand to VCAM-1 exhibit selective, avid, and focal adhesion to sites of atherosclerosis.
Biotechnology and bioengineering 2008;101(2):400-7.
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2008: Christman Mark A; Goetz Douglas J; Dickerson Eric; McCall Kelly D; Lewis Christopher J; Benencia Fabian; Silver Mitchell J; Kohn Leonard D; Malgor Ramiro
Wnt5a is expressed in murine and human atherosclerotic lesions.
American journal of physiology. Heart and circulatory physiology 2008;294(6):H2864-70.
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2008: Giuliani Cesidio; Noguchi Yoshihiko; Harii Norikazu; Napolitano Giorgio; Tatone Dante; Bucci Ines; Piantelli Mauro; Monaco Fabrizio; Kohn Leonard D
The flavonoid quercetin regulates growth and gene expression in rat FRTL-5 thyroid cells.
Endocrinology 2008;149(1):84-92.
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2007: McCall Kelly D; Harii Norikazu; Lewis Christopher J; Malgor Ramiro; Kim Won Bae; Saji Motoyasu; Kohn Aimee D; Moon Randall T; Kohn Leonard D
High basal levels of functional toll-like receptor 3 (TLR3) and noncanonical Wnt5a are expressed in papillary thyroid cancer and are coordinately decreased by phenylmethimazole together with cell proliferation and migration.
Endocrinology 2007;148(9):4226-37.
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2007: Grassadonia Antonino; Tinari Nicola; Fiorentino Bruno; Nakazato Minoru; Chung Hyun-Kyung; Giuliani Cesidio; Napolitano Giorgio; Iacobelli Stefano; Howcroft T Kevin; Singer Dinah S; Kohn Leonard D;
Upstream stimulatory factor regulates constitutive expression and hormonal suppression of the 90K (Mac-2BP) protein.
Endocrinology 2007;148(7):3507-17.
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2007: Kim Won Bae; Lewis Christopher J; McCall Kelly D; Malgor Ramiro; Kohn Aimee D; Moon Randall T; Kohn Leonard D
Overexpression of Wnt-1 in thyrocytes enhances cellular growth but suppresses transcription of the thyroperoxidase gene via different signaling mechanisms.
The Journal of endocrinology 2007;193(1):93-106.
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2006: Giuliani C; Saji M; Bucci I; Fiore G; Liberatore M; Singer D S; Monaco F; Kohn L D; Napolitano G
Transcriptional regulation of major histocompatibility complex class I gene by insulin and IGF-I in FRTL-5 thyroid cells.
The Journal of endocrinology 2006;189(3):605-15.
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2006: Suzuki Koichi; Kohn Leonard D
Differential regulation of apical and basal iodide transporters in the thyroid by thyroglobulin.
The Journal of endocrinology 2006;189(2):247-55.
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2005: Sakhalkar Harshad S; Hanes Justin; Fu Jie; Benavides Uruguaysito; Malgor Ramiro; Borruso Cheri L; Kohn Leonard D; Kurjiaka David T; Goetz Douglas J
Enhanced adhesion of ligand-conjugated biodegradable particles to colitic venules.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(7):792-4.
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2005: Harii Norikazu; Lewis Christopher J; Vasko Vasilly; McCall Kelly; Benavides-Peralta Uruguaysito; Sun Xiaolu; Ringel Matthew D; Saji Motoyasu; Giuliani Cesidio; Napolitano Giorgio; Goetz Douglas J; Kohn Leonard D
Thyrocytes express a functional toll-like receptor 3: overexpression can be induced by viral infection and reversed by phenylmethimazole and is associated with Hashimoto's autoimmune thyroiditis.
Molecular endocrinology (Baltimore, Md.) 2005;19(5):1231-50.
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2004: Grassadonia Antonino; Tinari Nicola; Fiorentino Bruno; Suzuki Koichi; Nakazato Minoru; De Tursi Michele; Giuliani Cesidio; Napolitano Giorgio; Singer Dinah S; Iacobelli Stefano; Kohn Leonard D
The 90K protein increases major histocompatibility complex class I expression and is regulated by hormones, gamma-interferon, and double-strand polynucleotides.
Endocrinology 2004;145(10):4728-36.
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2004: Yoshida Akio; Hisatome Ichiro; Taniguchi Shinichi; Sasaki Norihiro; Yamamoto Yasutaka; Miake Junichiro; Fukui Hiroko; Shimizu Hideki; Okamura Tomohisa; Okura Tsuyoshi; Igawa Osamu; Shigemasa Chiaki; Green Eric D; Kohn Leonard D; Suzuki Koichi
Mechanism of iodide/chloride exchange by pendrin.
Endocrinology 2004;145(9):4301-8.
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2004: Dagia Nilesh M; Harii Norikazu; Meli Antonella E; Sun Xiaolu; Lewis Christopher J; Kohn Leonard D; Goetz Douglas J
Phenyl methimazole inhibits TNF-alpha-induced VCAM-1 expression in an IFN regulatory factor-1-dependent manner and reduces monocytic cell adhesion to endothelial cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):2041-9.
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2003: Pacifico Francesco; Montuori Nunzia; Mellone Stefano; Liguoro Domenico; Ulianich Luca; Caleo Alessia; Troncone Giancarlo; Kohn Leonard D; Di Jeso Bruno; Consiglio Eduardo
The RHL-1 subunit of the asialoglycoprotein receptor of thyroid cells: cellular localization and its role in thyroglobulin endocytosis.
Molecular and cellular endocrinology 2003;208(1-2):51-9.
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2003: Kohn Leonard D; Harii Norikazu
Thyrotropin receptor autoantibodies (TSHRAbs): epitopes, origins and clinical significance.
Autoimmunity 2003;36(6-7):331-7.
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2003: Saunier Bertrand; Triyatni Miriam; Ulianich Luca; Maruvada Padma; Yen Paul; Kohn Leonard D
Role of the asialoglycoprotein receptor in binding and entry of hepatitis C virus structural proteins in cultured human hepatocytes.
Journal of virology 2003;77(1):546-59.
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2002: Rotman-Pikielny Pnina; Hirschberg Koret; Maruvada Padma; Suzuki Koichi; Royaux Ines E; Green Eric D; Kohn Leonard D; Lippincott-Schwartz Jennifer; Yen Paul M
Retention of pendrin in the endoplasmic reticulum is a major mechanism for Pendred syndrome.
Human molecular genetics 2002;11(21):2625-33.
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2002: Triyatni Miriam; Saunier Bertrand; Maruvada Padma; Davis Anthony R; Ulianich Luca; Heller Theo; Patel Arvind; Kohn Leonard D; Liang T Jake
Interaction of hepatitis C virus-like particles and cells: a model system for studying viral binding and entry.
Journal of virology 2002;76(18):9335-44.
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2002: Yoshida Akio; Taniguchi Shinichi; Hisatome Ichiro; Royaux Ines E; Green Eric D; Kohn Leonard D; Suzuki Koichi
Pendrin is an iodide-specific apical porter responsible for iodide efflux from thyroid cells.
The Journal of clinical endocrinology and metabolism 2002;87(7):3356-61.
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2002: Napolitano Giorgio; Bucci Ines; Giuliani Cesidio; Massafra Cinzia; Di Petta Cinzia; Devangelio Eleonora; Singer Dinah S; Monaco Fabrizio; Kohn Leonard D
High glucose levels increase major histocompatibility complex class I gene expression in thyroid cells and amplify interferon-gamma action.
Endocrinology 2002;143(3):1008-17.
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2002: Suzuki K; Yanagi M; Mori-Aoki A; Moriyama E; Ishii K J; Kohn L D
Transfection of single-stranded hepatitis A virus RNA activates MHC class I pathway.
Clinical and experimental immunology 2002;127(2):234-42.
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2002: Suzuki Koichi; Royaux Ines E; Everett Lorraine A; Mori-Aoki Atsumi; Suzuki Sayuri; Nakamura Kazuaki; Sakai Takafumi; Katoh Ryohei; Toda Shuji; Green Eric D; Kohn Leonard D
Expression of PDS/Pds, the Pendred syndrome gene, in endometrium.
The Journal of clinical endocrinology and metabolism 2002;87(2):938.
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2001: Ishii K J; Suzuki K; Coban C; Takeshita F; Itoh Y; Matoba H; Kohn L D; Klinman D M
Genomic DNA released by dying cells induces the maturation of APCs.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(5):2602-7.
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2001: Saito J; Kohn A D; Roth R A; Noguchi Y; Tatsumo I; Hirai A; Suzuki K; Kohn L D; Saji M; Ringel M D
Regulation of FRTL-5 thyroid cell growth by phosphatidylinositol (OH) 3 kinase-dependent Akt-mediated signaling.
Thyroid : official journal of the American Thyroid Association 2001;11(4):339-51.
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2001: Kohn L D; Suzuki K; Nakazato M; Royaux I; Green E D
Effects of thyroglobulin and pendrin on iodide flux through the thyrocyte.
Trends in endocrinology and metabolism: TEM 2001;12(1):10-6.
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2000: Mori-Aoki A; Pietrarelli M; Nakazato M; Caturegli P; Kohn L D; Suzuki K
Class II transactivator suppresses transcription of thyroid-specific genes.
Biochemical and biophysical research communications 2000;278(1):58-62.
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2000: Nakazato M; Chung H K; Ulianich L; Grassadonia A; Suzuki K; Kohn L D
Thyroglobulin repression of thyroid transcription factor 1 (TTF-1) gene expression is mediated by decreased DNA binding of nuclear factor I proteins which control constitutive TTF-1 expression.
Molecular and cellular biology 2000;20(22):8499-512.
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2000: Suzuki K; Nakazato M; Ulianich L; Mori-Aoki A; Moriyama E; Chung H K; Pietrarelli M; Grassadonia A; Matoba H; Kohn L D
Thyroglobulin autoregulation of thyroid-specific gene expression and follicular function.
Reviews in endocrine & metabolic disorders 2000;1(3):217-24.
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2000: Medina D L; Suzuki K; Pietrarelli M; Okajima F; Kohn L D; Santisteban P
Role of insulin and serum on thyrotropin regulation of thyroid transcription factor-1 and pax-8 genes expression in FRTL-5 thyroid cells.
Thyroid : official journal of the American Thyroid Association 2000;10(4):295-303.
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2000: Napolitano G; Montani V; Giuliani C; Di Vincenzo S; Bucci I; Todisco V; Laglia G; Coppa A; Singer D S; Nakazato M; Kohn L D; Colletta G; Monaco F
Transforming growth factor-beta1 down-regulation of major histocompatibility complex class I in thyrocytes: coordinate regulation of two separate elements by thyroid-specific as well as ubiquitous transcription factors.
Molecular endocrinology (Baltimore, Md.) 2000;14(4):486-505.
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2000: Giuliani C; Napolitano G; Mastino A; Di Vincenzo S; D'Agostini C; Grelli S; Bucci I; Singer D S; Kohn L D; Monaco F; Garaci E; Favalli C
Thymosin-alpha1 regulates MHC class I expression in FRTL-5 cells at transcriptional level.
European journal of immunology 2000;30(3):778-86.
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2000: Schuppert F; Ehrenthal D; Frilling A; Suzuki K; Napolitano G; Kohn L D
Increased major histocompatibility complex (MHC) expression in nontoxic goiters is associated with iodide depletion, enhanced ability of the follicular thyroglobulin to increase MHC gene expression, and thyroid autoantibodies.
The Journal of clinical endocrinology and metabolism 2000;85(2):858-67.
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2000: Royaux I E; Suzuki K; Mori A; Katoh R; Everett L A; Kohn L D; Green E D
Pendrin, the protein encoded by the Pendred syndrome gene (PDS), is an apical porter of iodide in the thyroid and is regulated by thyroglobulin in FRTL-5 cells.
Endocrinology 2000;141(2):839-45.
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2000: Kohn L D; Shimojo N; Kohno Y; Suzuki K
An animal model of Graves' disease: understanding the cause of autoimmune hyperthyroidism.
Reviews in endocrine & metabolic disorders 2000;1(1-2):59-67.
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2000: Kirshner S; Palmer L; Bodor J; Saji M; Kohn L D; Singer D S
Major histocompatibility class I gene transcription in thyrocytes: a series of interacting regulatory DNA sequence elements mediate thyrotropin/cyclic adenosine 3',5'-monophosphate repression.
Molecular endocrinology (Baltimore, Md.) 2000;14(1):82-98.
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2000: Kohn L D; Napolitano G; Singer D S; Molteni M; Scorza R; Shimojo N; Kohno Y; Mozes E; Nakazato M; Ulianich L; Chung H K; Matoba H; Saunier B; Suzuki K; Schuppert F; Saji M
Graves' disease: a host defense mechanism gone awry.
International reviews of immunology 2000;19(6):633-64.
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1999: Suzuki K; Mori A; Saito J; Moriyama E; Ullianich L; Kohn L D
Follicular thyroglobulin suppresses iodide uptake by suppressing expression of the sodium/iodide symporter gene.
Endocrinology 1999;140(11):5422-30.
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1999: Ulianich L; Suzuki K; Mori A; Nakazato M; Pietrarelli M; Goldsmith P; Pacifico F; Consiglio E; Formisano S; Kohn L D
Follicular thyroglobulin (TG) suppression of thyroid-restricted genes involves the apical membrane asialoglycoprotein receptor and TG phosphorylation.
The Journal of biological chemistry 1999;274(35):25099-107.
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1999: Singer D S; Zinger H; Kohn L D; Mozes E
Differing MHC class I requirements for induction and propagation of experimental systemic lupus erythematosus.
European journal of immunology 1999;29(7):2259-68.
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1999: Suzuki K; Mori A; Lavaroni S; Ulianich L; Miyagi E; Saito J; Nakazato M; Pietrarelli M; Shafran N; Grassadonia A; Kim W B; Consiglio E; Formisano S; Kohn L D
Thyroglobulin regulates follicular function and heterogeneity by suppressing thyroid-specific gene expression.
Biochimie 1999;81(4):329-40.
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1999: Suzuki K; Mori A; Lavaroni S; Miyagi E; Ulianich L; Katoh R; Kawaoi A; Kohn L D
In vivo expression of thyroid transcription factor-1 RNA and its relation to thyroid function and follicular heterogeneity: identification of follicular thyroglobulin as a feedback suppressor of thyroid transcription factor-1 RNA levels and thyroglobulin synthesis.
Thyroid : official journal of the American Thyroid Association 1999;9(4):319-31.
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1999: Suzuki K; Mori A; Ishii K J; Saito J; Singer D S; Klinman D M; Krause P R; Kohn L D
Activation of target-tissue immune-recognition molecules by double-stranded polynucleotides.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2285-90.
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1998: Suzuki K; Lavaroni S; Mori A; Okajima F; Kimura S; Katoh R; Kawaoi A; Kohn L D
Thyroid transcription factor 1 is calcium modulated and coordinately regulates genes involved in calcium homeostasis in C cells.
Molecular and cellular biology 1998;18(12):7410-22.
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1998: Suzuki K; Lavaroni S; Mori A; Ohta M; Saito J; Pietrarelli M; Singer D S; Kimura S; Katoh R; Kawaoi A; Kohn L D
Autoregulation of thyroid-specific gene transcription by thyroglobulin.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(14):8251-6.
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1998: Suzuki K; Kobayashi Y; Katoh R; Kohn L D; Kawaoi A
Identification of thyroid transcription factor-1 in C cells and parathyroid cells.
Endocrinology 1998;139(6):3014-7.
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1998: Balducci-Silano P L; Suzuki K; Ohta M; Saito J; Ohmori M; Montani V; Napolitano G; Shong M; Taniguchi S I; Pietrarelli M; Lavaroni S; Mori A; Singer D S; Kohn L D
Regulation of major histocompatibility (MHC) class II human leukocyte antigen-DR alpha gene expression in thyrocytes by single strand binding protein-1, a transcription factor that also regulates thyrotropin receptor and MHC class I gene expression.
Endocrinology 1998;139(5):2300-13.
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1998: Mozes E; Zinger H; Kohn L D; Singer D S
Spontaneous autoimmune disease in (NZB x NZW)F1 mice is ameliorated by treatment with methimazole.
Journal of clinical immunology 1998;18(2):106-13.
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1998: Taniguchi S I; Shong M; Giuliani C; Napolitano G; Saji M; Montani V; Suzuki K; Singer D S; Kohn L D
Iodide suppression of major histocompatibility class I gene expression in thyroid cells involves enhancer A and the transcription factor NF-kappa B.
Molecular endocrinology (Baltimore, Md.) 1998;12(1):19-33.
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1998: Montani V; Shong M; Taniguchi S I; Suzuki K; Giuliani C; Napolitano G; Saito J; Saji M; Fiorentino B; Reimold A M; Singer D S; Kohn L D
Regulation of major histocompatibility class II gene expression in FRTL-5 thyrocytes: opposite effects of interferon and methimazole.
Endocrinology 1998;139(1):290-302.
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1998: Montani V; Taniguchi S I; Shong M; Suzuki K; Ohmori M; Giuliani C; Napolitano G; Saji M; Fiorentino B; Reimold A M; Ting J P; Kohn L D; Singer D S
Major histocompatibility class II HLA-DR alpha gene expression in thyrocytes: counter regulation by the class II transactivator and the thyroid Y box protein.
Endocrinology 1998;139(1):280-9.
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1997: Schuppert F; Rambusch E; Kirchner H; Atzpodien J; Kohn L D; von zur Mühlen A
Patients treated with interferon-alpha, interferon-beta, and interleukin-2 have a different thyroid autoantibody pattern than patients suffering from endogenous autoimmune thyroid disease.
Thyroid : official journal of the American Thyroid Association 1997;7(6):837-42.
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1997: Sarlis N J; Brucker-Davis F; Swift J P; Tahara K; Kohn L D
Graves' disease following thyrotoxic painless thyroiditis. Analysis of antibody activities against the thyrotropin receptor in two cases.
Thyroid : official journal of the American Thyroid Association 1997;7(6):829-36.
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1997: Kohn L D; Suzuki K; Hoffman W H; Tombaccini D; Marcocci C; Shimojo N; Watanabe Y; Amino N; Cho B Y; Kohno Y; Hirai A; Tahara K
Characterization of monoclonal thyroid-stimulating and thyrotropin binding-inhibiting autoantibodies from a Hashimoto's patient whose children had intrauterine and neonatal thyroid disease.
The Journal of clinical endocrinology and metabolism 1997;82(12):3998-4009.
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1997: Saji M; Shong M; Napolitano G; Palmer L A; Taniguchi S I; Ohmori M; Ohta M; Suzuki K; Kirshner S L; Giuliani C; Singer D S; Kohn L D
Regulation of major histocompatibility complex class I gene expression in thyroid cells. Role of the cAMP response element-like sequence.
The Journal of biological chemistry 1997;272(32):20096-107.
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1997: Singer D S; Mozes E; Kirshner S; Kohn L D
Role of MHC class I molecules in autoimmune disease.
Critical reviews in immunology 1997;17(5-6):463-8.
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1996: Zeiger M A; Saji M; Caturegli P; Westra W H; Kohn L D; Levine M A
Transformation of rat thyroid follicular cells stably transfected with cholera toxin A1 fragment.
Endocrinology 1996;137(12):5392-9.
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1996: Ohmori M; Ohta M; Shimura H; Shimurat Y; Suzuki K; Kohn L D
Cloning of the single strand DNA-binding protein important for maximal expression and thyrotropin (TSH)-induced negative regulation of the TSH receptor.
Molecular endocrinology (Baltimore, Md.) 1996;10(11):1407-24.
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1996: Dallas J S; Cunningham S J; Patibandla S A; Seetharamaiah G S; Morris J C; Tahara K; Kohn L D; Prabhakar B S
Thyrotropin (TSH) receptor antibodies (TSHrAb) can inhibit TSH-mediated cyclic adenosine 3',5'- monophosphate production in thyroid cells by either blocking TSH binding or affecting a step subsequent to TSH binding.
Endocrinology 1996;137(8):3329-39.
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1996: Laglia G; Zeiger M A; Leipricht A; Caturegli P; Levine M A; Kohn L D; Saji M
Increased cyclic adenosine 3',5'-monophosphate inhibits G protein-coupled activation of phospholipase C in rat FRTL-5 thyroid cells.
Endocrinology 1996;137(8):3170-6.
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1996: Ohmori M; Shimura H; Shimura Y; Kohn L D
A Y-box protein is a suppressor factor that decreases thyrotropin receptor gene expression.
Molecular endocrinology (Baltimore, Md.) 1996;10(1):76-89.
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1995: Giuliani C; Saji M; Napolitano G; Palmer L A; Taniguchi S I; Shong M; Singer D S; Kohn L D
Hormonal modulation of major histocompatibility complex class I gene expression involves an enhancer A-binding complex consisting of Fra-2 and the p50 subunit of NF-kappa B.
The Journal of biological chemistry 1995;270(19):11453-62.
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1995: Shimura H; Shimura Y; Ohmori M; Ikuyama S; Kohn L D
Single strand DNA-binding proteins and thyroid transcription factor-1 conjointly regulate thyrotropin receptor gene expression.
Molecular endocrinology (Baltimore, Md.) 1995;9(5):527-39.
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1995: Ohmori M; Shimura H; Shimura Y; Ikuyama S; Kohn L D
Characterization of an up-stream thyroid transcription factor-1-binding site in the thyrotropin receptor promoter.
Endocrinology 1995;136(1):269-82.
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1995: Kohn L D; Shimura H; Shimura Y; Hidaka A; Giuliani C; Napolitano G; Ohmori M; Laglia G; Saji M
The thyrotropin receptor.
Vitamins and hormones 1995;50():287-384.
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1994: Shimura Y; Shimura H; Ohmori M; Ikuyama S; Kohn L D
Identification of a novel insulin-responsive element in the rat thyrotropin receptor promoter.
The Journal of biological chemistry 1994;269(50):31908-14.
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1994: Shimura H; Okajima F; Ikuyama S; Shimura Y; Kimura S; Saji M; Kohn L D
Thyroid-specific expression and cyclic adenosine 3',5'-monophosphate autoregulation of the thyrotropin receptor gene involves thyroid transcription factor-1.
Molecular endocrinology (Baltimore, Md.) 1994;8(8):1049-69.
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1994: Singer D S; Kohn L D; Zinger H; Mozes E
Methimazole prevents induction of experimental systemic lupus erythematosus in mice.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(2):873-80.
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1994: Hidaka A; Ban T; Panesar N S; Minegishi T; Kohn L D; Tahara K
Thyrotropin stimulation of the lutropin/choriogonadotropin receptor: different sites mediate agonist activity and high affinity binding.
Thyroid : official journal of the American Thyroid Association 1994;4(4):447-57.
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1993: Shimura H; Ikuyama S; Shimura Y; Kohn L D
The cAMP response element in the rat thyrotropin receptor promoter. Regulation by each decanucleotide of a flanking tandem repeat uses different, additive, and novel mechanisms.
The Journal of biological chemistry 1993;268(32):24125-37.
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1993: Hidaka A; Okajima F; Ban T; Kosugi S; Kondo Y; Kohn L D
Receptor cross-talk can optimize assays for autoantibodies to the thyrotropin receptor: effect of phenylisopropyladenosine on adenosine 3',5'-monophosphate and inositol phosphate levels in rat FRTL-5 thyroid cells.
The Journal of clinical endocrinology and metabolism 1993;77(5):1164-9.
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1993: Hidaka A; Minegishi T; Kohn L D
Thyrotropin, like luteinizing hormone (LH) and chorionic gonadotropin (CG), increases cAMP and inositol phosphate levels in cells with recombinant human LH/CG receptor.
Biochemical and biophysical research communications 1993;196(1):187-95.
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1993: Desai R K; Dallas J S; Gupta M K; Seetharamaiah G S; Fan J L; Tahara K; Kohn L D; Prabhakar B S
Dual mechanism of perturbation of thyrotropin-mediated activation of thyroid cells by antibodies to the thyrotropin receptor (TSHR) and TSHR-derived peptides.
The Journal of clinical endocrinology and metabolism 1993;77(3):658-63.
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1993: Kosugi S; Okajima F; Ban T; Hidaka A; Shenker A; Kohn L D
Substitutions of different regions of the third cytoplasmic loop of the thyrotropin (TSH) receptor have selective effects on constitutive, TSH-, and TSH receptor autoantibody-stimulated phosphoinositide and 3',5'-cyclic adenosine monophosphate signal generation.
Molecular endocrinology (Baltimore, Md.) 1993;7(8):1009-20.
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1993: Mozes E; Kohn L D; Hakim F; Singer D S
Resistance of MHC class I-deficient mice to experimental systemic lupus erythematosus.
Science (New York, N.Y.) 1993;261(5117):91-3.
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1993: Kosugi S; Ban T; Akamizu T; Valente W; Kohn L D
Use of thyrotropin receptor (TSHR) mutants to detect stimulating TSHR antibodies in hypothyroid patients with idiopathic myxedema, who have blocking TSHR antibodies.
The Journal of clinical endocrinology and metabolism 1993;77(1):19-24.
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1993: Kosugi S; Ban T; Kohn L D
Identification of thyroid-stimulating antibody-specific interaction sites in the N-terminal region of the thyrotropin receptor.
Molecular endocrinology (Baltimore, Md.) 1993;7(1):114-30.
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1993: Seetharamaiah G S; Desai R K; Dallas J S; Tahara K; Kohn L D; Prabhakar B S
Induction of TSH binding inhibitory immunoglobulins with the extracellular domain of human thyrotropin receptor produced using baculovirus expression system.
Autoimmunity 1993;14(4):315-20.
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1992: Kosugi S; Ban T; Akamizu T; Kohn L D
Role of cysteine residues in the extracellular domain and exoplasmic loops of the transmembrane domain of the TSH receptor: effect of mutation to serine on TSH receptor activity and response to thyroid stimulating autoantibodies.
Biochemical and biophysical research communications 1992;189(3):1754-62.
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1992: Kosugi S; Okajima F; Ban T; Hidaka A; Shenker A; Kohn L D
Mutation of alanine 623 in the third cytoplasmic loop of the rat thyrotropin (TSH) receptor results in a loss in the phosphoinositide but not cAMP signal induced by TSH and receptor autoantibodies.
The Journal of biological chemistry 1992;267(34):24153-6.
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1992: Ikuyama S; Shimura H; Hoeffler J P; Kohn L D
Role of the cyclic adenosine 3',5'-monophosphate response element in efficient expression of the rat thyrotropin receptor promoter.
Molecular endocrinology (Baltimore, Md.) 1992;6(10):1701-15.
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1992: Saji M; Moriarty J; Ban T; Singer D S; Kohn L D
Major histocompatibility complex class I gene expression in rat thyroid cells is regulated by hormones, methimazole, and iodide as well as interferon.
The Journal of clinical endocrinology and metabolism 1992;75(3):871-8.
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1992: Ban T; Kosugi S; Kohn L D
Specific antibody to the thyrotropin receptor identifies multiple receptor forms in membranes of cells transfected with wild-type receptor complementary deoxyribonucleic acid: characterization of their relevance to receptor synthesis, processing, structure, and function.
Endocrinology 1992;131(2):815-29.
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1992: Ikuyama S; Niller H H; Shimura H; Akamizu T; Kohn L D
Characterization of the 5'-flanking region of the rat thyrotropin receptor gene.
Molecular endocrinology (Baltimore, Md.) 1992;6(5):793-804.
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1992: Saji M; Moriarty J; Ban T; Kohn L D; Singer D S
Hormonal regulation of major histocompatibility complex class I genes in rat thyroid FRTL-5 cells: thyroid-stimulating hormone induces a cAMP-mediated decrease in class I expression.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(5):1944-8.
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1992: Kosugi S; Ban T; Akamizu T; Kohn L D
Identification of separate determinants on the thyrotropin receptor reactive with Graves' thyroid-stimulating antibodies and with thyroid-stimulating blocking antibodies in idiopathic myxedema: these determinants have no homologous sequence on gonadotropin receptors.
Molecular endocrinology (Baltimore, Md.) 1992;6(2):168-80.
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1992: Saji M; Akamizu T; Sanchez M; Obici S; Avvedimento E; Gottesman M E; Kohn L D
Regulation of thyrotropin receptor gene expression in rat FRTL-5 thyroid cells.
Endocrinology 1992;130(1):520-33.
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1992: Kohn L D; Kosugi S; Ban T; Saji M; Ikuyama S; Giuliani C; Hidaka A; Shimura H; Akamizu T; Tahara K
Molecular basis for the autoreactivity against thyroid stimulating hormone receptor.
International reviews of immunology 1992;9(2):135-65.
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1991: Kosugi S; Ban T; Akamizu T; Kohn L D
Further characterization of a high affinity thyrotropin binding site on the rat thyrotropin receptor which is an epitope for blocking antibodies from idiopathic myxedema patients but not thyroid stimulating antibodies from Graves' patients.
Biochemical and biophysical research communications 1991;180(2):1118-24.
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1991: Kosugi S; Ban T; Akamizu T; Kohn L D
Site-directed mutagenesis of a portion of the extracellular domain of the rat thyrotropin receptor important in autoimmune thyroid disease and nonhomologous with gonadotropin receptors. Relationship of functional and immunogenic domains.
The Journal of biological chemistry 1991;266(29):19413-8.
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1991: Tahara K; Ban T; Minegishi T; Kohn L D
Immunoglobulins from Graves' disease patients interact with different sites on TSH receptor/LH-CG receptor chimeras than either TSH or immunoglobulins from idiopathic myxedema patients.
Biochemical and biophysical research communications 1991;179(1):70-7.
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1991: Takai O; Desai R K; Seetharamaiah G S; Jones C A; Allaway G P; Akamizu T; Kohn L D; Prabhakar B S
Prokaryotic expression of the thyrotropin receptor and identification of an immunogenic region of the protein using synthetic peptides.
Biochemical and biophysical research communications 1991;179(1):319-26.
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1991: Akamizu T; Saji M; Ikuyama S; Kosugi S; Tahara K; Kohn L D
The TSH receptor in autoimmune Basedow's disease.
Experimental and clinical endocrinology 1991;97(2-3):153-9.
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1991: Saji M; Ikuyama S; Akamizu T; Kohn L D
Increases in cytosolic Ca++ down regulate thyrotropin receptor gene expression by a mechanism different from the cAMP signal.
Biochemical and biophysical research communications 1991;176(1):94-101.
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1991: Saji M; Kohn L D
Insulin and insulin-like growth factor-I inhibit thyrotropin-increased iodide transport in serum-depleted FRTL-5 rat thyroid cells: modulation of adenosine 3',5'-monophosphate signal action.
Endocrinology 1991;128(2):1136-43.
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1991: Tahara K; Grollman E F; Saji M; Kohn L D
Regulation of prostaglandin synthesis by thyrotropin, insulin or insulin-like growth factor-I, and serum in FRTL-5 rat thyroid cells.
The Journal of biological chemistry 1991;266(1):440-8.
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1991: Kosugi S; Akamizu T; Takai O; Prabhakar B S; Kohn L D
The extracellular domain of the TSH receptor has an immunogenic epitope reactive with Graves' IgG but unrelated to receptor function as well as determinants having different roles for high affinity TSH binding and the activity of thyroid-stimulating autoantibodies.
Thyroid : official journal of the American Thyroid Association 1991;1(4):321-30.
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1990: Saji M; Kohn L D
Effect of hydrocortisone on the ability of thyrotropin to increase deoxyribonucleic acid synthesis and iodide uptake in FRTL-5 rat thyroid cells: opposite regulation of adenosine 3',5'-monophosphate signal action.
Endocrinology 1990;127(4):1867-76.
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1990: Bellur S; Tahara K; Saji M; Grollman E F; Kohn L D
Repeatedly passed FRTL-5 rat thyroid cells can develop insulin and insulin-like growth factor-I-sensitive cyclooxygenase and prostaglandin E2 isomerase-like activities together with altered basal and thyrotropin-responsive thymidine incorporation into DNA.
Endocrinology 1990;127(3):1526-40.
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1990: Akamizu T; Ikuyama S; Saji M; Kosugi S; Kozak C; McBride O W; Kohn L D
Cloning, chromosomal assignment, and regulation of the rat thyrotropin receptor: expression of the gene is regulated by thyrotropin, agents that increase cAMP levels, and thyroid autoantibodies.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(15):5677-81.
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1990: Akamizu T; Saji M; Kohn L D
A microsequencing approach to identify proteins which appear to interact with thyrotropin in rat FRTL-5 thyroid cells.
Biochemical and biophysical research communications 1990;170(1):351-8.
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1990: Coutelier J P; Kehrl J H; Bellur S S; Kohn L D; Notkins A L; Prabhakar B S
Binding and functional effects of thyroid stimulating hormone on human immune cells.
Journal of clinical immunology 1990;10(4):204-10.
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1990: Akamizu T; Kosugi S; Kohn L D
Thyrotropin receptor processing and interaction with thyrotropin.
Biochemical and biophysical research communications 1990;169(3):947-52.
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1990: Aloj S M; Grieco D; Kohn A D; Nikodem V M; Kohn L D
Thyrotropin regulation of malic enzyme in FRTL-5 rat thyroid cells.
Molecular endocrinology (Baltimore, Md.) 1990;4(4):611-22.
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1990: Allaway G P; Vivino A A; Kohn L D; Notkins A L; Prabhakar B S
Characterization of the 70KDA component of the human Ku autoantigen expressed in insect cell nuclei using a recombinant baculovirus vector.
Biochemical and biophysical research communications 1990;168(2):747-55.
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1989: Isozaki O; Kohn L D; Kozak C A; Kimura S
Thyroid peroxidase: rat cDNA sequence, chromosomal localization in mouse, and regulation of gene expression by comparison to thyroglobulin in rat FRTL-5 cells.
Molecular endocrinology (Baltimore, Md.) 1989;3(11):1681-92.
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1989: Zarrilli R; Oates E L; McBride O W; Lerman M I; Chan J Y; Santisteban P; Ursini M V; Notkins A L; Kohn L D
Sequence and chromosomal assignment of a novel cDNA identified by immunoscreening of a thyroid expression library: similarity to a family of mitochondrial solute carrier proteins.
Molecular endocrinology (Baltimore, Md.) 1989;3(9):1498-505.
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1989: Chan J Y; Lerman M I; Prabhakar B S; Isozaki O; Santisteban P; Kuppers R C; Oates E L; Notkins A L; Kohn L D
Cloning and characterization of a cDNA that encodes a 70-kDa novel human thyroid autoantigen.
The Journal of biological chemistry 1989;264(7):3651-4.
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1989: Kohn A D; Chan J; Grieco D; Nikodem V M; Aloj S M; Kohn L D
Thyrotropin increases malic enzyme messenger ribonucleic acid levels in rat FRTL-5 thyroid cells.
Molecular endocrinology (Baltimore, Md.) 1989;3(3):532-8.
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1989: Kohn L D; Saji M; Akamizu T; Ikuyama S; Isozaki O; Kohn A D; Santisteban P; Chan J Y; Bellur S; Rotella C M
Receptors of the thyroid: the thyrotropin receptor is only the first violinist of a symphony orchestra.
Advances in experimental medicine and biology 1989;261():151-209.
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1989: Perrotti N; Rotella C M; Alvarez F V; Kohn L D; Taylor S
Characterization of receptors for insulin and insulin-like growth factor-1 on FRTL-5 thyroid cells.
Advances in experimental medicine and biology 1989;261():105-19.
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1989: Tahara K; Saji M; Aloj S M; Kohn L D
The arachidonic acid signal system in the thyroid: regulation by thyrotropin and insulin/IGF-I.
Advances in experimental medicine and biology 1989;261():295-326.
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1987: Isozaki O; Kohn L D
Control of c-fos and c-myc proto-oncogene induction in rat thyroid cells in culture.
Molecular endocrinology (Baltimore, Md.) 1987;1(11):839-48.
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1987: Chan J; Santisteban P; De Luca M; Isozaki O; Grollman E; Kohn L
TSH receptor structure.
Acta endocrinologica. Supplementum 1987;281():166-72.
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1987: Isozaki O; Santisteban P; Chan J; Grollman E; Kohn L
Insulin and insulin-like growth factor-I (IGF-I) regulate differentiation as well as growth in FRTL-5 cells.
Acta endocrinologica. Supplementum 1987;281():288-92.
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1987: Grollman E F; Bone E; Chan J; Corda D; Isozaki O; Marcocci C; Santisteban P; Kohn L D
TSH and biogenic amine signals in the regulation of thyroid function: independent regulation by protein kinase C and G proteins.
Acta endocrinologica. Supplementum 1987;281():199-202.
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1986: Rotella C M; Zonefrati R; Toccafondi R; Valente W A; Kohn L D
Ability of monoclonal antibodies to the thyrotropin receptor to increase collagen synthesis in human fibroblasts: an assay which appears to measure exophthalmogenic immunoglobulins in Graves' sera.
The Journal of clinical endocrinology and metabolism 1986;62(2):357-67.
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1986: Kohn L D; Alvarez F; Marcocci C; Kohn A D; Corda D; Hoffman W E; Tombaccini D; Valente W A; de Luca M; Santisteban P
Monoclonal antibody studies defining the origin and properties of autoantibodies in Graves' disease.
Annals of the New York Academy of Sciences 1986;475():157-73.
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1984: Lacetti P; Tombaccini D; Aloj S; Grollman E F; Kohn L D
Gangliosides, the thyrotropin receptor, and autoimmune thyroid disease.
Advances in experimental medicine and biology 1984;174():355-67.
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1983: Marcocci C; Valente W A; Pinchera A; Aloj S M; Kohn L D; Grollman E F
Graves' IgG stimulation of iodide uptake in FRTL-5 rat thyroid cells: a clinical assay complementing FRTL-5 assays measuring adenylate cyclase and growth-stimulating antibodies in autoimmune thyroid disease.
Journal of endocrinological investigation 1983;6(6):463-71.
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1983: Valente W A; Vitti P; Rotella C M; Vaughan M M; Aloj S M; Grollman E F; Ambesi-Impiombato F S; Kohn L D
Antibodies that promote thyroid growth. A distinct population of thyroid-stimulating autoantibodies.
The New England journal of medicine 1983;309(17):1028-34.
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1983: Vitti P; Rotella C M; Valente W A; Cohen J; Aloj S M; Laccetti P; Ambesi-Impiombato F S; Grollman E F; Pinchera A; Toccafondi R; Kohn L D
Characterization of the optimal stimulatory effects of graves' monoclonal and serum immunoglobulin G on adenosine 3',5'-monophosphate production in fRTL-5 thyroid cells: a potential clinical assay.
The Journal of clinical endocrinology and metabolism 1983;57(4):782-91.
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1983: Yavin E; Yavin Z; Kohn L D
Temperature-mediated interaction of tetanus toxin with cerebral neuron cultures: characterization of a neuraminidase-insensitive toxin-receptor complex.
Journal of neurochemistry 1983;40(5):1212-9.
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1983: Laccetti P; Grollman E F; Aloj S M; Kohn L D
Ganglioside dependent return of TSH receptor function in a rat thyroid tumor with a TSH receptor defect.
Biochemical and biophysical research communications 1983;110(3):772-8.
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1983: Kohn L D; Valente W A; Laccetti P; Cohen J L; Aloj S M; Grollman E F
Multicomponent structure of the thyrotropin receptor: relationship to Graves' disease.
Life sciences 1983;32(1-2):15-30.
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1983: Valente W A; Vitti P; Kohn L D; Brandi M L; Rotella C M; Toccafondi R; Tramontano D; Aloj S M; Ambesi-Impiombato F S
The relationship of growth and adenylate cyclase activity in cultured thyroid cells: separate bioeffects of thyrotropin.
Endocrinology 1983;112(1):71-9.
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1982: Valente W A; Vitti P; Yavin Z; Yavin E; Rotella C M; Grollman E F; Toccafondi R S; Kohn L D
Monoclonal antibodies to the thyrotropin receptor: stimulating and blocking antibodies derived from the lymphocytes of patients with Graves disease.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(21):6680-4.
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1982: Valente W A; Yavin Z; Yavin E; Grollman E F; Schneider M; Rotella C M; Zonefrati R; Toccafondi R S; Kohn L D
Monoclonal antibodies to the thyrotropin receptor: the identification of blocking and stimulating antibodies.
Journal of endocrinological investigation 1982;5(5):293-301.
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1982: Vitti P; Valente W A; Ambesi-Impiombato F S; Fenzi G F; Pinchera A; Kohn L D
Graves' IgG stimulation of continuously cultured rat thyroid cells: a sensitive and potentially useful clinical assay.
Journal of endocrinological investigation 1982;5(3):179-82.
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1982: Yavin Z; Yavin E; Kohn L D
Sequestration of tetanus toxin in developing neuronal cell cultures.
Journal of neuroscience research 1982;7(3):267-78.
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1982: Kohn L D; Aloj S M; Beguinot F; Vitti P; Yavin E; Yavin Z; Laccetti P; Grollman E F; Valente W A
Molecular interactions at the cell surface: role of glycoconjugates and membrane lipids in receptor recognition processes.
Progress in clinical and biological research 1982;97():55-83.
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1981: De Wolf M J; Vitti P; Ambesi-Impiombato F S; Kohn L D
Thyroid membrane ADP ribosyltransferase activity. Stimulation by thyrotropin and activity in functioning and nonfunctioning rat thyroid cells in culture.
The Journal of biological chemistry 1981;256(23):12287-96.
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1981: Goldberg R L; Costa T; Habig W H; Kohn L D; Hardegree M C
Characterization of fragment C and tetanus toxin binding to rat brain membranes.
Molecular pharmacology 1981;20(3):565-70.
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1981: Yavin E; Yavin Z; Habig W H; Hardegree M C; Kohn L D
Tetanus toxin association with developing neuronal cell cultures. Kinetic parameters and evidence for ganglioside-mediated internalization.
The Journal of biological chemistry 1981;256(13):7014-22.
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1981: Yavin E; Yavin Z; Schneider M D; Kohn L D
Monoclonal antibodies to the thyrotropin receptor: implications for receptor structure and the action of autoantibodies in Graves disease.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(5):3180-4.
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1980: Morris N P; Consiglio E; Kohn L D; Habig W H; Hardegree M C; Helting T B
Interaction of fragments B and C of tetanus toxin with neural and thyroid membranes and with gangliosides.
The Journal of biological chemistry 1980;255(13):6071-6.
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