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Josef Köhrle

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Ulrich Schweizer; Josef Köhrle
Function of thyroid hormone transporters in the central nervous system.
Albertinka J Murk; Robert Opitz; Eddy Rijntjes; Theo Traas; Theo J Visser; Menghang Xia; Bas J Blaauboer; Rebecca Clewell; Kevin M Crofton; Milou M L Dingemans; J David Furlow; Robert Kavlock; Josef Köhrle; arno gutleb
Mechanism-based testing strategy using in vitro approaches for identification of thyroid hormone disrupting chemicals.
José M Ordóñez-Mena; Lutz Schomburg; Ben Schöttker; Ulrike Haug; Bernd Holleczek; Josef Köhrle; Heiko Müller; Hermann Brenner
Serum 25-hydroxyvitamin d and cancer risk in older adults: results from a large german prospective cohort study.

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All Publications

2013: Ulrich Schweizer; Josef Köhrle
Function of thyroid hormone transporters in the central nervous system.
Biochimica et biophysica acta 2013;1830(7):3965-73.
2013: Albertinka J Murk; Robert Opitz; Eddy Rijntjes; Theo Traas; Theo J Visser; Menghang Xia; Bas J Blaauboer; Rebecca Clewell; Kevin M Crofton; Milou M L Dingemans; J David Furlow; Robert Kavlock; Josef Köhrle; arno gutleb
Mechanism-based testing strategy using in vitro approaches for identification of thyroid hormone disrupting chemicals.
Toxicology in vitro : an international journal published in association with BIBRA 2013;27(4):1320-46.
2013: José M Ordóñez-Mena; Lutz Schomburg; Ben Schöttker; Ulrike Haug; Bernd Holleczek; Josef Köhrle; Heiko Müller; Hermann Brenner
Serum 25-hydroxyvitamin d and cancer risk in older adults: results from a large german prospective cohort study.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2013;22(5):905-16.
2013: Waldemar B Minich; Nils G. Morgenthaler; Nora Dehina; Anja Eckstein; Josef Köhrle; Christian Schwiebert; Tim Welsink; Lutz Schomburg
Autoantibodies to the IGF1 receptor in Graves' orbitopathy.
The Journal of clinical endocrinology and metabolism 2013;98(2):752-60.
2012: Branka Sosic-Jurjevic; Vladimir Ajdzanovic; Branko Filipovic; Milica Manojlovic-Stojanoski; Verica Milosevic; Kostja Renko; Josef Köhrle
Orchidectomy of middle-aged rats decreases liver deiodinase 1 and pituitary deiodinase 2 activity.
The Journal of endocrinology 2012;215(2):247-56.
2012: Antonia Hoeg; Josef Köhrle; Sandra Mueller; Elaine Murphy; David M Reid; Christian Roux; Lutz Schomburg; Richard Eastell; Dieter Felsenberg; Claus C Glüer; Apostolos Gogakos; Graham R Williams
Bone turnover and bone mineral density are independently related to selenium status in healthy euthyroid postmenopausal women.
The Journal of clinical endocrinology and metabolism 2012;97(11):4061-70.
2012: Jochen Springer; Anika Tschirner; Stephan von Haehling; Eva K Wirth; Volker Adams; Stefan D Anker; Josep M Argiles; Kai Hartman; Josef Köhrle; Nadine Möller; Sandra Palus; Silvia Busquets Ruis; Wolfram Doehner
Inhibition of xanthine oxidase reduces wasting and improves outcome in a rat model of cancer cachexia.
International journal of cancer. Journal international du cancer 2012;131(9):2187-96.
2012: Jazmin Chiu-Ugalde; Noelia Fradejas-Villar; Marc O Klein; Josef Köhrle; Kostja Renko; Remy Sapin; Lutz Schomburg; Eva K Wirth; Ulrich Schweizer
Thyroid function is maintained despite increased oxidative stress in mice lacking selenoprotein biosynthesis in thyroid epithelial cells.
Antioxidants & redox signaling 2012;17(6):902-13.
2012: Kostja Renko; Lutz Schomburg; Franziska Hiller; Carolin S Hoefig; Josef Köhrle
Identification of iopanoic acid as substrate of type 1 deiodinase by a novel nonradioactive iodide-release assay.
Endocrinology 2012;153(5):2506-13.
2012: Johann Ockenga; Ajmal Omar; Tatjana Schuetz; Uwe J F Tietge; Luzia Valentini; Franziska Wohlgemuth; Julian R Davis; Daniel duPlessis; Karen Featherstone; Silja Glaeser; Esmatollah Kasim; Josef Köhrle; Thomas Kroencke; Heike Biebermann; Georg Brabant
Plasma bile acids are associated with energy expenditure and thyroid function in humans.
The Journal of clinical endocrinology and metabolism 2012;97(2):535-42.
2012: Ben Schöttker; Ulrike Haug; Eugène H J M Jansen; Josef Köhrle; Lutz Schomburg; Hermann Brenner
Standardization of misleading immunoassay based 25-hydroxyvitamin D levels with liquid chromatography tandem-mass spectrometry in a large cohort study.
PloS one 2012;7(11):e48774.
2011: Doreen Braun; Annette Grüters; Marc O Klein; Josef Köhrle; Nathalie Reix; Eva K Wirth; Franziska Wohlgemuth; Ulrich Schweizer
Aminoaciduria, but normal thyroid hormone levels and signalling, in mice lacking the amino acid and thyroid hormone transporter Slc7a8.
The Biochemical journal 2011;439(2):249-55.
2011: Eva K Wirth; Jazmin Chiu-Ugalde; Martin Hrabé De Angelis; Marc O Klein; Josef Köhrle; Heiko Krude; Ilona Mossbrugger; Leticia Quintanilla-Martinez; Thomas Riebel; Karin Rothe; Remy Sapin; Kurt W Schmid; Ulrich Schweizer; Sien-Yi Sheu; Annette Grüters
Monocarboxylate transporter 8 deficiency: altered thyroid morphology and persistent high triiodothyronine/thyroxine ratio after thyroidectomy.
European journal of endocrinology / European Federation of Endocrine Societies 2011;165(4):555-61.
2011: Carolin S Hoefig; Josef Köhrle; Kostja Renko; Marc Birringer; Lutz Schomburg
Comparison of different selenocompounds with respect to nutritional value vs. toxicity using liver cells in culture.
The Journal of nutritional biochemistry 2011;22(10):945-55.
2011: Christian H Nickel; Juliane Ruedinger; Janin Schulte; Katharina Blume; Sven Giersdorf; Oliver Hartmann; Josef Köhrle; Silke Maile; Franziska Misch; Roland Bingisser
Copeptin and peroxiredoxin-4 independently predict mortality in patients with nonspecific complaints presenting to the emergency department.
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 2011;18(8):851-9.
2011: Carolin S Hoefig; Josef Köhrle; Georg Brabant; Kashinath Dixit; Beng Yap; Christian J Strasburger; Zida Wu
Evidence for extrathyroidal formation of 3-iodothyronamine in humans as provided by a novel monoclonal antibody-based chemiluminescent serum immunoassay.
The Journal of clinical endocrinology and metabolism 2011;96(6):1864-72.
2011: Janin Schulte; Joachim Struck; Josef Köhrle; Beat Müller
Circulating levels of peroxiredoxin 4 as a novel biomarker of oxidative stress in patients with sepsis.
Shock (Augusta, Ga.) 2011;35(5):460-5.
2011: Lone Banke Rasmussen; Lutz Schomburg; Josef Köhrle; Inge Bülow Pedersen; Birgit Hollenbach; Antonia Hög; Lars Ovesen; Hans Perrild; Peter Laurberg
Selenium status, thyroid volume, and multiple nodule formation in an area with mild iodine deficiency.
European journal of endocrinology / European Federation of Endocrine Societies 2011;164(4):585-90.
2011: Doreen Braun; Anita Kinne; Anja U Bräuer; Remy Sapin; Marc O Klein; Josef Köhrle; Eva K Wirth; Ulrich Schweizer
Developmental and cell type-specific expression of thyroid hormone transporters in the mouse brain and in primary brain cells.
Glia 2011;59(3):463-71.
2011: Gunnar Kleinau; Josef Köhrle; Heiko Krude; Daniela Nürnberg; Juliane Pratzka; Torsten Schöneberg; Dagmar Führer; Annette Grüters; Heike Biebermann
Differential modulation of Beta-adrenergic receptor signaling by trace amine-associated receptor 1 agonists.
PloS one 2011;6(10):e27073.
2011: Gunnar Kleinau; Josef Köhrle; Heiko Krude; Ulrich Schweizer; Annette Grüters; Anita Kinne; Heike Biebermann
Insights into molecular properties of the human monocarboxylate transporter 8 by combining functional with structural information.
Thyroid research 2011;4 Suppl 1():S4.
2010: Bernhard Michalke; Anatoly Skalny; Josef Köhrle
Report on the 4th International FESTEM Symposium on "Recent advances in trace element research: From experiments to nutritional and clinical applications in humans" (Saint Petersburg, Russia, June 09-12th, 2010).
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2010;24(4):221-2.
2010: Jazmin Chiu-Ugalde; Franziska Theilig; Thomas Behrends; Julia Drebes; Carolin Sieland; Prema Subbarayal; Josef Köhrle; Annette Hammes; Lutz Schomburg; Ulrich Schweizer
Mutation of megalin leads to urinary loss of selenoprotein P and selenium deficiency in serum, liver, kidneys and brain.
The Biochemical journal 2010;431(1):103-11.
2010: Janin Schulte; Joachim Struck; Andreas Bergmann; Josef Köhrle
Immunoluminometric assay for quantification of peroxiredoxin 4 in human serum.
Clinica chimica acta; international journal of clinical chemistry 2010;411(17-18):1258-63.
2010: Anita Kinne; Gunnar Kleinau; Carolin S Hoefig; Annette Grüters; Josef Köhrle; Gerd Krause; Ulrich Schweizer
Essential molecular determinants for thyroid hormone transport and first structural implications for monocarboxylate transporter 8.
The Journal of biological chemistry 2010;285(36):28054-63.
2010: Bogusz Trojanowicz; Carsten Sekulla; Kerstin Lorenz; Josef Köhrle; Rainer Finke; Henning Dralle; Cuong Hoang-Vu
Proteomic approach reveals novel targets for retinoic acid-mediated therapy of thyroid carcinoma.
Molecular and cellular endocrinology 2010;325(1-2):110-7.
2010: Branislav Radović; Ragna Hussong; Clarissa Gerhäuser; Walter Meinl; Norbert Frank; Hans Becker; Josef Köhrle
Xanthohumol, a prenylated chalcone from hops, modulates hepatic expression of genes involved in thyroid hormone distribution and metabolism.
Molecular nutrition & food research 2010;54 Suppl 2():S225-35.
2010: Josef Köhrle; Georg Brabant
[Synthesis, metabolism and diagnostics of thyroid hormones].
Der Internist 2010;51(5):559-60, 562-7.
2010: Beate C Braun; Hellmuth-Alexander Meyer; Antje Reetz; Ulrike Fuhrmann; Josef Köhrle
Effect of mutations of the human serpin protein corticosteroid-binding globulin on cortisol-binding, thermal and protease sensitivity.
The Journal of steroid biochemistry and molecular biology 2010;120(1):30-7.
2010: Andrea Ernst; Katharina Buerger; Oliver Hartmann; Richard Dodel; Carmen Noelker; Norbert Sommer; Markus Schwarz; Josef Köhrle; Andreas Bergmann; Harald Hampel
Midregional Proenkephalin A and N-terminal Protachykinin A are decreased in the cerebrospinal fluid of patients with dementia disorders and acute neuroinflammation.
Journal of neuroimmunology 2010;221(1-2):62-7.
2010: Eva K Wirth; Marcus Conrad; Jochen Winterer; Christian Wozny; Bradley A Carlson; Stephan Roth; Dietmar Schmitz; Georg W Bornkamm; Vincenzo Coppola; Lino Tessarollo; Lutz Schomburg; Josef Köhrle; Dolph L Hatfield; Ulrich Schweizer
Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(3):844-52.
2010: Marek Ruchala; Ewelina Szczepanek; Witold Szaflarski; Jerzy Moczko; Agata Czarnywojtek; Leszek Pietz; Michal Nowicki; Marek Niedziela; Maciej Zabel; Josef Köhrle; Jerzy Sowinski
Increased risk of thyroid pathology in patients with thyroid hemiagenesis: results of a large cohort case-control study.
European journal of endocrinology / European Federation of Endocrine Societies 2010;162(1):153-60.
2009: Josef Köhrle; Roland Gärtner
Selenium and thyroid.
Best practice & research. Clinical endocrinology & metabolism 2009;23(6):815-27.
2009: Anita Kinne; Stephan Roth; Heike Biebermann; Josef Köhrle; Annette Grüters; Ulrich Schweizer
Surface translocation and tri-iodothyronine uptake of mutant MCT8 proteins are cell type-dependent.
Journal of molecular endocrinology 2009;43(6):263-71.
2009: Hellmuth-Alexander Meyer; Birgit Hollenbach; Carsten Stephan; Tobias Endermann; Nils G. Morgenthaler; Henning Cammann; Josef Köhrle; Klaus Jung; Lutz Schomburg
Reduced serum selenoprotein P concentrations in German prostate cancer patients.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009;18(9):2386-90.
2009: Eva K Wirth; Stephan Roth; Cristiane Blechschmidt; Sabine M Hölter; Lore Becker; Ildiko Racz; Andreas Zimmer; Thomas Klopstock; Valerie Gailus-Durner; Helmut Fuchs; Wolfgang Wurst; Thomas Naumann; Anja Bräuer; Martin Hrabé De Angelis; Josef Köhrle; Annette Grüters; Ulrich Schweizer
Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(30):9439-49.
2009: Peter Josef Hofmann; Lutz Schomburg; Josef Köhrle
Interference of endocrine disrupters with thyroid hormone receptor-dependent transactivation.
Toxicological sciences : an official journal of the Society of Toxicology 2009;110(1):125-37.
2009: Kostja Renko; Peter J Hofmann; Mette Stoedter; Birgit Hollenbach; Thomas Behrends; Josef Köhrle; Ulrich Schweizer; Lutz Schomburg
Down-regulation of the hepatic selenoprotein biosynthesis machinery impairs selenium metabolism during the acute phase response in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(6):1758-65.
2009: Lutz Schomburg; Alexandra M Dumitrescu; Xiao-Hui Liao; Bassam Bin-Abbas; Johanna Hoeflich; Josef Köhrle; Samuel Refetoff
Selenium supplementation fails to correct the selenoprotein synthesis defect in subjects with SBP2 gene mutations.
Thyroid : official journal of the American Thyroid Association 2009;19(3):277-81.
2009: Bogusz Trojanowicz; Anja Winkler; Kathrin Hammje; Zhouxun Chen; Carsten Sekulla; Dagobert Glanz; Cornelia Schmutzler; Birgit Mentrup; Sabine Hombach-Klonisch; Thomas Klonisch; Rainer Finke; Josef Köhrle; Henning Dralle; Cuong Hoang-Vu
Retinoic acid-mediated down-regulation of ENO1/MBP-1 gene products caused decreased invasiveness of the follicular thyroid carcinoma cell lines.
Journal of molecular endocrinology 2009;42(3):249-60.
2008: Lutz Schomburg; Josef Köhrle
On the importance of selenium and iodine metabolism for thyroid hormone biosynthesis and human health.
Molecular nutrition & food research 2008;52(11):1235-46.
2008: Susanne Piehl; Thomas Heberer; Gabor Balizs; Thomas S Scanlan; Josef Köhrle
Development of a validated liquid chromatography/tandem mass spectrometry method for the distinction of thyronine and thyronamine constitutional isomers and for the identification of new deiodinase substrates.
Rapid communications in mass spectrometry : RCM 2008;22(20):3286-96.
2008: Nicole Schliebe; Rainer Strotmann; Kathy Busse; Doreen Mitschke; Heike Biebermann; Lutz Schomburg; Josef Köhrle; Jörg Bär; Holger Römpler; Jürgen Wess; Torsten Schöneberg; Katrin Sangkuhl
V2 vasopressin receptor deficiency causes changes in expression and function of renal and hypothalamic components involved in electrolyte and water homeostasis.
American journal of physiology. Renal physiology 2008;295(4):F1177-90.
2008: Ulrich Schweizer; Jazmin Chiu; Josef Köhrle
Peroxides and peroxide-degrading enzymes in the thyroid.
Antioxidants & redox signaling 2008;10(9):1577-92.
2008: Andrea Ernst; Jennifer Suhr; Josef Köhrle; Andreas Bergmann
Detection of stable N-terminal protachykinin A immunoreactivity in human plasma and cerebrospinal fluid.
Peptides 2008;29(7):1201-6.
2008: S Piehl; T Heberer; G Balizs; Thomas S Scanlan; R Smits; Beate Koksch; Josef Köhrle
Thyronamines are isozyme-specific substrates of deiodinases.
Endocrinology 2008;149(6):3037-45.
2008: Josef Köhrle
Environment and endocrinology: the case of thyroidology.
Annales d'endocrinologie 2008;69(2):116-22.
2008: Kostja Renko; Margarethe Werner; Ingrid Renner-Müller; Trevor G Cooper; Ching-Hei Yeung; Birgit Hollenbach; Marcus Scharpf; Josef Köhrle; Lutz Schomburg; Ulrich Schweizer
Hepatic selenoprotein P (SePP) expression restores selenium transport and prevents infertility and motor-incoordination in Sepp-knockout mice.
The Biochemical journal 2008;409(3):741-9.
2008: Andrzej Lewinski; Josef Köhrle; Maria Alevizaki; Barbara Jarzab
Welcome to thyroid research.
Thyroid research 2008;1(1):1.
2008: Birgit Hollenbach; Nils G. Morgenthaler; Joachim Struck; Christine Alonso; Andreas Bergmann; Josef Köhrle; Lutz Schomburg
New assay for the measurement of selenoprotein P as a sepsis biomarker from serum.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2008;22(1):24-32.
2007: Cornelia Schmutzler; Inka Gotthardt; Peter J Hofmann; Branislav Radovic; Gabor Kovacs; Luise Stemmler; Inga Nobis; Anja Bacinski; Birgit Mentrup; Petra Ambrugger; Annette Grüters; Ludwik K Malendowicz; Julie Christoffel; Hubertus Jarry; Dana Seidlovà-Wuttke; Wolfgang Wuttke; Josef Köhrle
Endocrine disruptors and the thyroid gland--a combined in vitro and in vivo analysis of potential new biomarkers.
Environmental health perspectives 2007;115 Suppl 1():77-83.
2007: Cornelia Schmutzler; Birgit Mentrup; Lutz Schomburg; Cuong Hoang-Vu; Volker Herzog; Josef Köhrle
Selenoproteins of the thyroid gland: expression, localization and possible function of glutathione peroxidase 3.
Biological chemistry 2007;388(10):1053-9.
2007: August Böck; Leopold Flohé; Josef Köhrle
Selenoproteins - biochemistry and clinical relevance.
Biological chemistry 2007;388(10):985-6.
2007: Holger Klammer; Christiane Schlecht; Wolfgang Wuttke; Cornelia Schmutzler; Inka Gotthardt; Josef Köhrle; Hubertus Jarry
Effects of a 5-day treatment with the UV-filter octyl-methoxycinnamate (OMC) on the function of the hypothalamo-pituitary-thyroid function in rats.
Toxicology 2007;238(2-3):192-9.
2007: M Scharpf; Ulrich Schweizer; Thomas Arzberger; Wolfgang Roggendorf; Lutz Schomburg; Josef Köhrle
Neuronal and ependymal expression of selenoprotein P in the human brain.
Journal of neural transmission (Vienna, Austria : 1996) 2007;114(7):877-84.
2007: Josef Köhrle
Thyroid hormone transporters in health and disease: advances in thyroid hormone deiodination.
Best practice & research. Clinical endocrinology & metabolism 2007;21(2):173-91.
2007: Cornelia Schmutzler; Anja Bacinski; Inka Gotthardt; Katrin Huhne; Petra Ambrugger; Holger Klammer; Christiane Schlecht; Cuong Hoang-Vu; Annette Grüters; Wolfgang Wuttke; Hubertus Jarry; Josef Köhrle
The ultraviolet filter benzophenone 2 interferes with the thyroid hormone axis in rats and is a potent in vitro inhibitor of human recombinant thyroid peroxidase.
Endocrinology 2007;148(6):2835-44.
2006: V F H Brauer; Ulrich Schweizer; Josef Köhrle; Ralf Paschke
Selenium and goiter prevalence in borderline iodine sufficiency.
European journal of endocrinology / European Federation of Endocrine Societies 2006;155(6):807-12.
2006: Cornelia Riese; Marten Michaelis; Birgit Mentrup; Franziska Götz; Josef Köhrle; Ulrich Schweizer; Lutz Schomburg
Selenium-dependent pre- and posttranscriptional mechanisms are responsible for sexual dimorphic expression of selenoproteins in murine tissues.
Endocrinology 2006;147(12):5883-92.
2006: Branislav Radović; Birgit Mentrup; Josef Köhrle
Genistein and other soya isoflavones are potent ligands for transthyretin in serum and cerebrospinal fluid.
The British journal of nutrition 2006;95(6):1171-6.
2006: Lutz Schomburg; Cornelia Riese; Marten Michaelis; Emine Griebert; Marc O Klein; Remy Sapin; Ulrich Schweizer; Josef Köhrle
Synthesis and metabolism of thyroid hormones is preferentially maintained in selenium-deficient transgenic mice.
Endocrinology 2006;147(3):1306-13.
2005: Florian Streckfuss; Inka Hamann; Lutz Schomburg; Marten Michaelis; Remy Sapin; Marc O Klein; Josef Köhrle; Ulrich Schweizer
Hepatic deiodinase activity is dispensable for the maintenance of normal circulating thyroid hormone levels in mice.
Biochemical and biophysical research communications 2005;337(2):739-45.
2005: Annavarapu Srinivas Rao; Peter E Goretzki; Josef Köhrle; Georg Brabant
Letter Re: Id1 gene expression in hyperplastic and neoplastic thyroid tissues.
The Journal of clinical endocrinology and metabolism 2005;90(10):5906.
2005: Branislav Radović; Cornelia Schmutzler; Josef Köhrle
Xanthohumol stimulates iodide uptake in rat thyroid-derived FRTL-5 cells.
Molecular nutrition & food research 2005;49(9):832-6.
2005: Josef Köhrle
Selenium and the control of thyroid hormone metabolism.
Thyroid : official journal of the American Thyroid Association 2005;15(8):841-53.
2005: Christian Obermaier; Vera Jankowski; Cornelia Schmutzler; Johann Bauer; Robert Wildgruber; Manfred Infanger; Josef Köhrle; Eberhard Krause; Gerhard Weber; Daniela Grimm
Free-flow isoelectric focusing of proteins remaining in cell fragments following sonication of thyroid carcinoma cells.
Electrophoresis 2005;26(11):2109-16.
2005: Marianne Menth; Cornelia Schmutzler; Birgit Mentrup; Cuong Hoang-Vu; Kazuhiko Takahashi; Tsutomu Honjoh; Josef Köhrle
Selenoprotein expression in Hürthle cell carcinomas and in the human Hürthle cell carcinoma line XTC.UC1.
Thyroid : official journal of the American Thyroid Association 2005;15(5):405-16.
2005: Samantha J Richardson; Julie A Monk; Caroline A Shepherdley; Lars O E Ebbesson; Frank Sin; Deborah M Power; Peter Frappell; Josef Köhrle; Marilyn Renfree
Developmentally regulated thyroid hormone distributor proteins in marsupials, a reptile, and fish.
American journal of physiology. Regulatory, integrative and comparative physiology 2005;288(5):R1264-72.
2005: Ulrich Schweizer; Florian Streckfuss; Paco Pelt; Bradley A Carlson; Dolph L Hatfield; Josef Köhrle; Lutz Schomburg
Hepatically derived selenoprotein P is a key factor for kidney but not for brain selenium supply.
The Biochemical journal 2005;386(Pt 2):221-6.
2004: Cornelia Schmutzler; Inka Hamann; Peter J Hofmann; Gabor Kovacs; Luise Stemmler; Birgit Mentrup; Lutz Schomburg; Petra Ambrugger; Annette Grüters; Dana Seidlova-Wuttke; Hubertus Jarry; Wolfgang Wuttke; Josef Köhrle
Endocrine active compounds affect thyrotropin and thyroid hormone levels in serum as well as endpoints of thyroid hormone action in liver, heart and kidney.
Toxicology 2004;205(1-2):95-102.
2004: Zhouxun Chen; Tarek Mustafa; Bogusz Trojanowicz; Michael Brauckhoff; Oliver Gimm; Cornelia Schmutzler; Josef Köhrle; Hans-Jürgen Holzhausen; Astrid Kehlen; Thomas Klonisch; Rainer Finke; Henning Dralle; Cuong Hoang-Vu
CD82, and CD63 in thyroid cancer.
International journal of molecular medicine 2004;14(4):517-27.
2004: Josef Köhrle
Guard your master: thyroid hormone receptors protect their gland of origin from thyroid cancer.
Endocrinology 2004;145(10):4427-9.
2004: Lutz Schomburg; Ulrich Schweizer; Josef Köhrle
Selenium and selenoproteins in mammals: extraordinary, essential, enigmatic.
Cellular and molecular life sciences : CMLS 2004;61(16):1988-95.
2004: Regina Brigelius-Flohé; Josef Köhrle
55th Mosbach Colloquium: how nutrients influence gene activity.
Biological chemistry 2004;385(7):569.
2004: Ulrich Schweizer; Anja U Bräuer; Josef Köhrle; Robert Nitsch; Nicolai E Savaskan
Selenium and brain function: a poorly recognized liaison.
Brain research. Brain research reviews 2004;45(3):164-78.
2004: Sarah Kaufmann; Cornelia Schmutzler; Lutz Schomburg; Carsten Körber; Markus Luster; Johann Rendl; Christoph Reiners; Josef Köhrle
Real time RT-PCR analysis of thyroglobulin mRNA in peripheral blood in patients with congenital athyreosis and with differentiated thyroid carcinoma after stimulation with recombinant human thyrotropin.
Endocrine regulations 2004;38(2):41-9.
2004: Josef Köhrle
[Thyroid hormone metabolism and action].
Zeitschrift für ärztliche Fortbildung und Qualitätssicherung 2004;98 Suppl 5():17-24.
2004: Cornelia Schmutzler; Cuong Hoang-Vu; Barbara Rüger; Josef Köhrle
Human thyroid carcinoma cell lines show different retinoic acid receptor repertoires and retinoid responses.
European journal of endocrinology / European Federation of Endocrine Societies 2004;150(4):547-56.
2004: Ulrich Schweizer; Marten Michaelis; Josef Köhrle; Lutz Schomburg
Efficient selenium transfer from mother to offspring in selenoprotein-P-deficient mice enables dose-dependent rescue of phenotypes associated with selenium deficiency.
The Biochemical journal 2004;378(Pt 1):21-6.
2004: Oliver Al-Taie; Nurcan Uceyler; Ursula Eubner; Franz Jakob; Hubert Mörk; Michael Scheurlen; Regina Brigelius-Flohe; Katrin Schöttker; Josef Abel; Andreas Thalheimer; Tiemo Katzenberger; Bertram Illert; Ralph Melcher; Josef Köhrle
Expression profiling and genetic alterations of the selenoproteins GI-GPx and SePP in colorectal carcinogenesis.
Nutrition and cancer 2004;48(1):6-14.
2003: Hubert Mörk; Michael Scheurlen; Oliver Al-Taie; Annette Zierer; Michael Kraus; Katrin Schöttker; Franz Jakob; Josef Köhrle
Glutathione peroxidase isoforms as part of the local antioxidative defense system in normal and Barrett's esophagus.
International journal of cancer. Journal international du cancer 2003;105(3):300-4.
2003: Lutz Schomburg; Ulrich Schweizer; Bettina Holtmann; Leopold Flohé; Michael Sendtner; Josef Köhrle
Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues.
The Biochemical journal 2003;370(Pt 2):397-402.
2003: Oliver Al-Taie; Jochen Seufert; Serhan Karvar; Christian Adolph; Hubert Mörk; Michael Scheurlen; Josef Köhrle; Franz Jakob
Selenium supplementation enhances low selenium levels and stimulates glutathione peroxidase activity in peripheral blood and distal colon mucosa in past and present carriers of colon adenomas.
Nutrition and cancer 2003;46(2):125-30.
2002: Michael B Zimmermann; Josef Köhrle
The impact of iron and selenium deficiencies on iodine and thyroid metabolism: biochemistry and relevance to public health.
Thyroid : official journal of the American Thyroid Association 2002;12(10):867-78.
2002: Oliver Al-Taie; Jochen Seufert; Hubert Mörk; Holger Treis; Birgit Mentrup; Andreas Thalheimer; Petr Starostik; Josef Abel; Michael Scheurlen; Josef Köhrle; Franz Jakob
A complex DNA-repeat structure within the Selenoprotein P promoter contains a functionally relevant polymorphism and is genetically unstable under conditions of mismatch repair deficiency.
European journal of human genetics : EJHG 2002;10(9):499-504.
2002: A Baur; M Buchfelder; Josef Köhrle
Expression of 5'-deiodinase enzymes in normal pituitaries and in various human pituitary adenomas.
European journal of endocrinology / European Federation of Endocrine Societies 2002;147(2):263-8.
2002: Cuong Hoang-Vu; Carsten Boltze; Oliver Gimm; Christopher Poremba; Barbara Dockhorn-Dworniczak; Josef Köhrle; Friedrich-Wilhelm Rath; Henning Dralle
Expression of telomerase genes in thyroid carcinoma.
International journal of oncology 2002;21(2):265-72.
2002: Július Brtko; J Bobálová; J Podoba; Cornelia Schmutzler; Josef Köhrle
Thyroid hormone receptors and type I iodothyronine 5'-deiodinase activity of human thyroid toxic adenomas and benign cold nodules.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2002;110(4):166-70.
2002: Dietmar Simon; Carsten Körber; Markus Krausch; J Segering; P Groth; R Görges; Frank Grünwald; Hans-Wilhelm Müller-Gärtner; Cornelia Schmutzler; Josef Köhrle; Hans-Dietrich Röher; Christoph Reiners
Clinical impact of retinoids in redifferentiation therapy of advanced thyroid cancer: final results of a pilot study.
European journal of nuclear medicine and molecular imaging 2002;29(6):775-82.
2002: Tatjana C Jakobs; Birgit Mentrup; Cornelia Schmutzler; Ingeborg Dreher; Josef Köhrle
Proinflammatory cytokines inhibit the expression and function of human type I 5'-deiodinase in HepG2 hepatocarcinoma cells.
European journal of endocrinology / European Federation of Endocrine Societies 2002;146(4):559-66.
2002: Cornelia Schmutzler; Thomas L Schmitt; F Glaser; Ulrich Loos; Josef Köhrle
The promoter of the human sodium/iodide-symporter gene responds to retinoic acid.
Molecular and cellular endocrinology 2002;189(1-2):145-55.
2002: Josef Köhrle
Iodothyronine deiodinases.
Methods in enzymology 2002;347():125-67.
2001: V Mostert; S Wolff; Ingeborg Dreher; Josef Köhrle; Josef Abel
Identification of an element within the promoter of human selenoprotein P responsive to transforming growth factor-beta.
European journal of biochemistry / FEBS 2001;268(23):6176-81.
2001: V Mostert; Ingeborg Dreher; Josef Köhrle; S Wolff; Josef Abel
Modulation of selenoprotein P expression by TGF-beta(1) is mediated by Smad proteins.
BioFactors (Oxford, England) 2001;14(1-4):135-42.
2000: Josef Köhrle
The deiodinase family: selenoenzymes regulating thyroid hormone availability and action.
Cellular and molecular life sciences : CMLS 2000;57(13-14):1853-63.
2000: A Baur; K Bauer; H Jarry; Josef Köhrle
Effects of proinflammatory cytokines on anterior pituitary 5'-deiodinase type I and type II.
The Journal of endocrinology 2000;167(3):505-15.
2000: Cornelia Schmutzler; Josef Köhrle
Retinoic acid redifferentiation therapy for thyroid cancer.
Thyroid : official journal of the American Thyroid Association 2000;10(5):393-406.
2000: Josef Köhrle
The selenoenzyme family of deiodinase isozymes controls local thyroid hormone availability.
Reviews in endocrine & metabolic disorders 2000;1(1-2):49-58.
2000: Hubert Mörk; Oliver Al-Taie; K Bähr; A Zierer; C Beck; Michael Scheurlen; Franz Jakob; Josef Köhrle
Inverse mRNA expression of the selenocysteine-containing proteins GI-GPx and SeP in colorectal adenomas compared with adjacent normal mucosa.
Nutrition and cancer 2000;37(1):108-16.
2000: Josef Köhrle
Thyroid hormone metabolism and action in the brain and pituitary.
Acta medica Austriaca 2000;27(1):1-7.
2000: K Hesse-Bähr; Ingeborg Dreher; Josef Köhrle
The influence of the cytokines Il-1beta and INFgamma on the expression of selenoproteins in the human hepatocarcinoma cell line HepG2.
BioFactors (Oxford, England) 2000;11(1-2):83-5.
1999: R Ebert-Dümig; Jochen Seufert; Doris Schneider; Josef Köhrle; Norbert Schütze; Franz Jakob
[Expression of selenoproteins in monocytes and macrophages--implications for the immune system].
Medizinische Klinik (Munich, Germany : 1983) 1999;94 Suppl 3():29-34.
1999: Josef Köhrle
Local activation and inactivation of thyroid hormones: the deiodinase family.
Molecular and cellular endocrinology 1999;151(1-2):103-19.
1999: Josef Köhrle
The trace element selenium and the thyroid gland.
Biochimie 1999;81(5):527-33.
1999: Josef Köhrle
[The sodium-iodide-symporter (NIS): function, regulation and clinical importance].
Zeitschrift für ärztliche Fortbildung und Qualitätssicherung 1999;93 Suppl 1():17-22.
1999: A Baur; Josef Köhrle
Type 1 deiodinase is stimulated by iodothyronines and involved in thyroid hormone metabolism in human somatomammotroph GX cells.
European journal of endocrinology / European Federation of Endocrine Societies 1999;140(4):367-70.
1999: Cuong Hoang-Vu; K Bull; I Schwarz; G Krause; Cornelia Schmutzler; G Aust; Josef Köhrle; H Dralle
Regulation of CD97 protein in thyroid carcinoma.
The Journal of clinical endocrinology and metabolism 1999;84(3):1104-9.
1999: Norbert Schütze; Jana Fritsche; R Ebert-Dümig; Doris Schneider; Josef Köhrle; R Andreesen; M Kreutz; Franz Jakob
The selenoprotein thioredoxin reductase is expressed in peripheral blood monocytes and THP1 human myeloid leukemia cells--regulation by 1,25-dihydroxyvitamin D3 and selenite.
BioFactors (Oxford, England) 1999;10(4):329-38.
1998: ralf winzer; Cornelia Schmutzler; Tatjana C Jakobs; Regina Ebert; Johann Rendl; Christoph Reiners; Franz Jakob; Josef Köhrle
Reverse transcriptase-polymerase chain reaction analysis of thyrocyte-relevant genes in fine-needle aspiration biopsies of the human thyroid.
Thyroid : official journal of the American Thyroid Association 1998;8(11):981-7.
1998: Josef Köhrle; Cornelia Schmutzler
[How does iodine reach the thyroid gland? Recent studies of the sodium-iodide symporter].
Der Internist 1998;39(6):560-5.
1998: Cornelia Schmutzler; Július Brtko; ralf winzer; Tatjana C Jakobs; Jutta Meissner-Weigl; D Simon; P E Goretzki; Josef Köhrle
Functional retinoid and thyroid hormone receptors in human thyroid-carcinoma cell lines and tissues.
International journal of cancer. Journal international du cancer 1998;76(3):368-76.
1998: Ingeborg Dreher; Norbert Schütze; A Baur; K Hesse; Doris Schneider; Josef Köhrle; Franz Jakob
Selenoproteins are expressed in fetal human osteoblast-like cells.
Biochemical and biophysical research communications 1998;245(1):101-7.
1998: Norbert Schütze; A Lechner; C Groll; Heide Siggelkow; Michael Hüfner; Josef Köhrle; Franz Jakob
The human analog of murine cystein rich protein 61 [correction of 16] is a 1alpha,25-dihydroxyvitamin D3 responsive immediate early gene in human fetal osteoblasts: regulation by cytokines, growth factors, and serum.
Endocrinology 1998;139(4):1761-70.
1998: Hubert Mörk; B Lex; Michael Scheurlen; Ingeborg Dreher; Norbert Schütze; Josef Köhrle; Franz Jakob
Expression pattern of gastrointestinal selenoproteins--targets for selenium supplementation.
Nutrition and cancer 1998;32(2):64-70.
1998: Cornelia Schmutzler; Josef Köhrle
Implications of the molecular characterization of the sodium-iodide symporter (NIS).
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 1998;106 Suppl 3():S1-10.
1998: Norbert Schütze; M Bachthaler; A Lechner; Josef Köhrle; Franz Jakob
Identification by differential display PCR of the selenoprotein thioredoxin reductase as a 1 alpha,25(OH)2-vitamin D3-responsive gene in human osteoblasts--regulation by selenite.
BioFactors (Oxford, England) 1998;7(4):299-310.
1997: Cornelia Schmutzler; ralf winzer; Jutta Meissner-Weigl; Josef Köhrle
Retinoic acid increases sodium/iodide symporter mRNA levels in human thyroid cancer cell lines and suppresses expression of functional symporter in nontransformed FRTL-5 rat thyroid cells.
Biochemical and biophysical research communications 1997;240(3):832-8.
1997: Ingeborg Dreher; Tatjana C Jakobs; Josef Köhrle
Cloning and characterization of the human selenoprotein P promoter. Response of selenoprotein P expression to cytokines in liver cells.
The Journal of biological chemistry 1997;272(46):29364-71.
1997: Franz Jakob; Hubert Mörk; Norbert Schütze; Ingeborg Dreher; Cornelia Schmutzler; B Lex; Josef Köhrle
[Selenoproteins in bone, gastrointestinal tract and thyroid gland of the human].
Medizinische Klinik (Munich, Germany : 1983) 1997;92 Suppl 3():24-6.
1997: A Baur; K Bauer; H Jarry; Josef Köhrle
3,5-diiodo-L-thyronine stimulates type 1 5'deiodinase activity in rat anterior pituitaries in vivo and in reaggregate cultures and GH3 cells in vitro.
Endocrinology 1997;138(8):3242-8.
1997: Tatjana C Jakobs; Cornelia Schmutzler; J Meissner; Josef Köhrle
The promoter of the human type I 5'-deiodinase gene--mapping of the transcription start site and identification of a DR+4 thyroid-hormone-responsive element.
European journal of biochemistry / FEBS 1997;247(1):288-97.
1997: Ingeborg Dreher; Cornelia Schmutzler; Franz Jakob; Josef Köhrle
Expression of selenoproteins in various rat and human tissues and cell lines.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 1997;11(2):83-91.
1997: Tatjana C Jakobs; MR Koehler; Cornelia Schmutzler; F Glaser; Michael Schmid; Josef Köhrle
Structure of the human type I iodothyronine 5'-deiodinase gene and localization to chromosome 1p32-p33.
Genomics 1997;42(2):361-3.
1997: Franz Jakob; Heide Siggelkow; D Homann; Josef Köhrle; J Adamski; Norbert Schütze
Local estradiol metabolism in osteoblast- and osteoclast-like cells.
The Journal of steroid biochemistry and molecular biology 1997;61(3-6):167-74.
1997: Josef Köhrle
[Transfer and metabolism of thyroid gland hormones in the placenta].
Acta medica Austriaca 1997;24(4):138-43.
1997: Josef Köhrle
Thyroid carcinoma: interrelationships between local thyroid hormone metabolism by the type I 5'-deiodinase and the expression of thyroid hormone receptors and other thyroid-specific (de-)differentiation markers.
Current topics in pathology. Ergebnisse der Pathologie 1997;91():83-116.
1996: Fritz Boege; Tobias Straub; A Kehr; C Boesenberg; K Christiansen; A Andersen; Franz Jakob; Josef Köhrle
Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I.
The Journal of biological chemistry 1996;271(4):2262-70.
1996: Cornelia Schmutzler; Július Brtko; K Bienert; Josef Köhrle
Effects of retinoids and role of retinoic acid receptors in human thyroid carcinomas and cell lines derived therefrom.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 1996;104 Suppl 4():16-9.
1996: Dietmar Simon; Josef Köhrle; Cornelia Schmutzler; K Mainz; Christoph Reiners; Hans-Dietrich Röher
Redifferentiation therapy of differentiated thyroid carcinoma with retinoic acid: basics and first clinical results.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 1996;104 Suppl 4():13-5.
1996: Josef Köhrle
Thyroid hormone deiodinases--a selenoenzyme family acting as gate keepers to thyroid hormone action.
Acta medica Austriaca 1996;23(1-2):17-30.
1995: Franz Jakob; D Homann; Jochen Seufert; Doris Schneider; Josef Köhrle
Expression and regulation of aromatase cytochrome P450 in THP 1 human myeloid leukaemia cells.
Molecular and cellular endocrinology 1995;110(1-2):27-33.
1995: Josef Köhrle; Franz Jakob; B Jany; K Wilms
[Cell differentiation and local regulatory systems].
Der Internist 1995;36(4):378-84.
1995: M Gross; M Oertel; Josef Köhrle
Differential selenium-dependent expression of type I 5'-deiodinase and glutathione peroxidase in the porcine epithelial kidney cell line LLC-PK1.
The Biochemical journal 1995;306 ( Pt 3)():851-6.
1995: Josef Köhrle; L Schomburg; S Drescher; E Fekete; Karl Bauer
Rapid stimulation of type I 5'-deiodinase in rat pituitaries by 3,3',5-triiodo-L-thyronine.
Molecular and cellular endocrinology 1995;108(1-2):17-21.
1994: B Schauder; L Schomburg; Josef Köhrle; Karl Bauer
Cloning of a cDNA encoding an ectoenzyme that degrades thyrotropin-releasing hormone.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(20):9534-8.
1994: R Schreck; Frank Schnieders; Cornelia Schmutzler; Josef Köhrle
Retinoids stimulate type I iodothyronine 5'-deiodinase activity in human follicular thyroid carcinoma cell lines.
The Journal of clinical endocrinology and metabolism 1994;79(3):791-8.
1994: Franz Jakob; Jochen Seufert; C Sarrazin; Doris Schneider; Josef Köhrle; Hans-Peter Tony
Topoisomerase I-inhibition enhances vitamin D-responsive expression of the receptor for lipopolysaccharide binding protein CD 14.
Biochemical and biophysical research communications 1994;199(2):531-9.
1994: Josef Köhrle
Thyroid hormone deiodination in target tissues--a regulatory role for the trace element selenium?
Experimental and clinical endocrinology 1994;102(2):63-89.
1993: M Oertel; M Gross; Hartmut Rokos; Josef Köhrle
Selenium-dependent regulation of type I 5'-deiodinase expression.
The American journal of clinical nutrition 1993;57(2 Suppl):313S-314S.
1992: Georg Brabant; P Bergmann; C M Kirsch; Josef Köhrle; R D Hesch; Alexander von zur Mühlen
Early adaptation of thyrotropin and thyroglobulin secretion to experimentally decreased iodine supply in man.
Metabolism: clinical and experimental 1992;41(10):1093-6.
1992: Cuong Hoang-Vu; Henning Dralle; S Schröder; M Oertel; Josef Köhrle; R D Hesch; Alexander von zur Mühlen; Georg Brabant
The nude rat is established as a model for endocrine studies: regulation of thyroid function and xenotransplantation of a thyroid tumor cell line.
Laboratory animal science 1992;42(2):164-7.
1992: Josef Köhrle; M Oertel; M Gross
Selenium supply regulates thyroid function, thyroid hormone synthesis and metabolism by altering the expression of the selenoenzymes Type I 5'-deiodinase and glutathione peroxidase.
Thyroidology / A.P.R.I.M 1992;4(1):17-21.
1992: Josef Köhrle
The trace components--selenium and flavonoids--affect iodothyronine deiodinases, thyroid hormone transport and TSH regulation.
Acta medica Austriaca 1992;19 Suppl 1():13-7.
1991: Georg Brabant; Carine Maenhaut; Josef Köhrle; GF Scheumann; Henning Dralle; Cuong Hoang-Vu; R D Hesch; Alexander von zur Mühlen; G Vassart; Jacques E Dumont
Human thyrotropin receptor gene: expression in thyroid tumors and correlation to markers of thyroid differentiation and dedifferentiation.
Molecular and cellular endocrinology 1991;82(1):R7-12.
1991: Janny P Schröder-van der Elst; Daan van der Heide; Josef Köhrle
In vivo effects of flavonoid EMD 21388 on thyroid hormone secretion and metabolism in rats.
The American journal of physiology 1991;261(2 Pt 1):E227-32.
1991: M Oertel; R O Hesch; Josef Köhrle
Expression of iodothyronine deiodinase in cultured thyroid cells.
Experimental and clinical endocrinology 1991;97(2-3):182-6.
1990: W Lueprasitsakul; S Alex; SL Fang; S Pino; K Irmscher; Josef Köhrle; Lewis E Braverman
Flavonoid administration immediately displaces thyroxine (T4) from serum transthyretin, increases serum free T4, and decreases serum thyrotropin in the rat.
Endocrinology 1990;126(6):2890-5.
1990: Josef Köhrle; Ulla rasmussen; D M Ekenbarger; S Alex; Hartmut Rokos; R D Hesch; Jack L Leonard
Affinity labeling of rat liver and kidney type I 5'-deiodinase. Identification of the 27-kDa substrate binding subunit.
The Journal of biological chemistry 1990;265(11):6155-63.
1990: Josef Köhrle; Ulla rasmussen; Hartmut Rokos; Jack L Leonard; R D Hesch
Selective affinity labeling of a 27-kDa integral membrane protein in rat liver and kidney with N-bromoacetyl derivatives of L-thyroxine and 3,5,3'-triiodo-L-thyronine.
The Journal of biological chemistry 1990;265(11):6146-54.
1990: M Spanka; R D Hesch; K Irmscher; Josef Köhrle
5'-Deiodination in rat hepatocytes: effects of specific flavonoid inhibitors.
Endocrinology 1990;126(3):1660-7.
1989: Ulla rasmussen; Josef Köhrle; Hartmut Rokos; R D Hesch
Thyroid hormone effect on rat heart mitochondrial proteins and affinity labeling with N-bromoacetyl-3,3',5-triiodo-L-thyronine. Lack of direct effect on the adenine nucleotide translocase.
FEBS letters 1989;255(2):385-90.
1989: Josef Köhrle; SL Fang; Y Yang; K Irmscher; R D Hesch; S Pino; S Alex; Lewis E Braverman
Rapid effects of the flavonoid EMD 21388 on serum thyroid hormone binding and thyrotropin regulation in the rat.
Endocrinology 1989;125(1):532-7.
1988: Josef Köhrle; M Spanka; K Irmscher; R D Hesch
Flavonoid effects on transport, metabolism and action of thyroid hormones.
Progress in clinical and biological research 1988;280():323-40.
1988: Josef Köhrle
Biochemistry of iodothyronine deiodination.
Acta medica Austriaca 1988;15 Suppl 1():22-4.