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Tadashi Kohyama

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Yu Mikami; Hajime Takizawa; Yasuhiro Yamauchi; Masafumi Horie; Taisuke Jo; Makiko Kase; Tadashi Kohyama; Takahide Nagase
Tumor necrosis factor superfamily member LIGHT induces epithelial-mesenchymal transition in A549 human alveolar epithelial cells.
Masafumi Horie; Tadashi Kohyama; Yu Mikami; Yasuyuki Morishita; Jun Nakajima; Mitsuhiro Ohshima; Akira Saito; Takahide Nagase
Characterization of human lung cancer-associated fibroblasts in three-dimensional in vitro co-culture model.
Yasuhiro Yamauchi; Taisuke Jo; Tadashi Kohyama; Takahide Nagase
Dynamic change in respiratory resistance during inspiratory and expiratory phases of tidal breathing in patients with chronic obstructive pulmonary disease.

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2012: Yu Mikami; Hajime Takizawa; Yasuhiro Yamauchi; Masafumi Horie; Taisuke Jo; Makiko Kase; Tadashi Kohyama; Takahide Nagase
Tumor necrosis factor superfamily member LIGHT induces epithelial-mesenchymal transition in A549 human alveolar epithelial cells.
Biochemical and biophysical research communications 2012;428(4):451-7.
2012: Masafumi Horie; Tadashi Kohyama; Yu Mikami; Yasuyuki Morishita; Jun Nakajima; Mitsuhiro Ohshima; Akira Saito; Takahide Nagase
Characterization of human lung cancer-associated fibroblasts in three-dimensional in vitro co-culture model.
Biochemical and biophysical research communications 2012;423(1):158-63.
2012: Yasuhiro Yamauchi; Taisuke Jo; Tadashi Kohyama; Takahide Nagase
Dynamic change in respiratory resistance during inspiratory and expiratory phases of tidal breathing in patients with chronic obstructive pulmonary disease.
International journal of chronic obstructive pulmonary disease 2012;7():259-69.
2011: Sumiko Kamitani; Yasuhiro Yamauchi; Shin Kawasaki; Kazutaka Takami; Hajime Takizawa; Takahide Nagase; Tadashi Kohyama
Simultaneous stimulation with TGF-β1 and TNF-α induces epithelial mesenchymal transition in bronchial epithelial cells.
International archives of allergy and immunology 2011;155(2):119-28.
2010: Tadashi Kohyama; Yasuhiro Yamauchi; Hajime Takizawa; Sumiko Kamitani; Shin Kawasaki; Takahide Nagase
Histamine stimulates human lung fibroblast migration.
Molecular and cellular biochemistry 2010;337(1-2):77-81.
2010: Yasuhiro Yamauchi; Tadashi Kohyama; Hajime Takizawa; Sumiko Kamitani; Masashi Desaki; Kazutaka Takami; Shin Kawasaki; Jun Kato; Takahide Nagase
Tumor necrosis factor-alpha enhances both epithelial-mesenchymal transition and cell contraction induced in A549 human alveolar epithelial cells by transforming growth factor-beta1.
Experimental lung research 2010;36(1):12-24.
2009: Tadashi Kohyama; Yasuhiro Yamauchi; Hajime Takizawa; Susumu Itakura; Sumiko Kamitani; Masashi Desaki; Shin Kawasaki; Takahide Nagase
Procaterol inhibits lung fibroblast migration.
Inflammation 2009;32(6):387-92.
2009: Roy-Akira Saito; Tetsuro Watabe; Kana Horiguchi; Tadashi Kohyama; Masao Saitoh; Takahide Nagase; Kohei Miyazono
Thyroid transcription factor-1 inhibits transforming growth factor-beta-mediated epithelial-to-mesenchymal transition in lung adenocarcinoma cells.
Cancer research 2009;69(7):2783-91.
2009: Kazuhiko Kikuchi; Tadashi Kohyama; Yasuhiro Yamauchi; Jun Kato; Kazutaka Takami; Hitoshi Okazaki; Masashi Desaki; Takahide Nagase; Stephen I Rennard; Hajime Takizawa
C-reactive protein modulates human lung fibroblast migration.
Experimental lung research 2009;35(1):48-58.
2008: Tadashi Kohyama; Yasuhiro Yamauchi; Hajime Takizawa; Susumu Itakura; Sumiko Kamitani; Jun Kato; Takahide Nagase
Clarithromycin inhibits fibroblast migration.
Respiratory medicine 2008;102(12):1769-76.
2008: Hidenori Kage; Tadashi Kohyama; Hiroshi Kitagawa; Daiya Takai; Yoshinobu Kanda; Nobuya Ohishi; Takahide Nagase
Non-infectious bronchiolitis as an early pulmonary complication of hematopoietic stem cell transplantation.
Internal medicine (Tokyo, Japan) 2008;47(1):61-4.
2006: Tetsu Kobayashi; Xiangde Liu; Fu-Qiang Wen; Tadashi Kohyama; Lei Shen; Xing Qi Wang; Mitsuyoshi Hashimoto; Lijun Mao; Shinsaku Togo; Shin Kawasaki; Hisatoshi Sugiura; Koichiro Kamio; Stephen I Rennard
Smad3 mediates TGF-beta1-induced collagen gel contraction by human lung fibroblasts.
Biochemical and biophysical research communications 2006;339(1):290-5.
2005: Jun Kato; Tadashi Kohyama; Hitoshi Okazaki; Masashi Desaki; Takashi Nagase; Stephen I Rennard; Hajime Takizawa
Leukotriene D4 potentiates fibronectin-induced migration of human lung fibroblasts.
Clinical immunology (Orlando, Fla.) 2005;117(2):177-81.
2005: Tetsu Kobayashi; Xiangde Liu; Fu-Qiang Wen; Qiuhong Fang; Shinji Abe; Xiang Qi Wang; Mitsuyoshi Hashimoto; Lei Shen; Shin Kawasaki; Hui Jung Kim; Tadashi Kohyama; Stephen I Rennard
Smad3 mediates TGF-beta1 induction of VEGF production in lung fibroblasts.
Biochemical and biophysical research communications 2005;327(2):393-8.
2005: Tetsu Kobayashi; Xiangde Liu; Hui Jung Kim; Tadashi Kohyama; Fu-Qiang Wen; Shinji Abe; Qiuhong Fang; Yun Kui Zhu; John R Spurzem; Peter Bitterman; Stephen I Rennard
TGF-beta1 and serum both stimulate contraction but differentially affect apoptosis in 3D collagen gels.
Respiratory research 2005;6():141.
2004: Q Fang; X Liu; S Abe; T Kobayashi; X Q Wang; Tadashi Kohyama; M Hashimoto; Todd A Wyatt; Stephen I Rennard
Thrombin induces collagen gel contraction partially through PAR1 activation and PKC-epsilon.
The European respiratory journal 2004;24(6):918-24.
2004: Huijung Kim; Xiangde Liu; Tetsu Kobayashi; Heather Conner; Tadashi Kohyama; Fu-Qiang Wen; Qiuhong Fang; Shinji Abe; Peter Bitterman; Stephen I Rennard
Reversible cigarette smoke extract-induced DNA damage in human lung fibroblasts.
American journal of respiratory cell and molecular biology 2004;31(5):483-90.
2004: Tadashi Kohyama; Xiangde Liu; Fu-Qiang Wen; Tetsu Kobayashi; Qiuhong Fang; Shinji Abe; Lenora Cieslinski; Mary S Barnette; Stephen I Rennard
Cytokines modulate cilomilast response in lung fibroblasts.
Clinical immunology (Orlando, Fla.) 2004;111(3):297-302.
2004: Fu-Qiang Wen; Xiangde Liu; Tetsu Kobayashi; Shinji Abe; Qiuhong Fang; Tadashi Kohyama; Ronald F Ertl; Yusuke Terasaki; Lidia Manouilova; Stephen I Rennard
Interferon-gamma inhibits transforming growth factor-beta production in human airway epithelial cells by targeting Smads.
American journal of respiratory cell and molecular biology 2004;30(6):816-22.
2004: Yasuhiro Yamauchi; Hitoshi Okazaki; Masashi Desaki; Tadashi Kohyama; Shin Kawasaki; Kazuhiko Yamamoto; Hajime Takizawa
Methotrexate induces interleukin-8 production by human bronchial and alveolar epithelial cells.
Clinical science (London, England : 1979) 2004;106(6):619-25.
2004: Huijung Kim; Xiangde Liu; Tadashi Kohyama; Tetsu Kobayashi; Heather Conner; Shinji Abe; Qiuhong Fang; Fu-Qiang Wen; Stephen I Rennard
Cigarette smoke stimulates MMP-1 production by human lung fibroblasts through the ERK1/2 pathway.
COPD 2004;1(1):13-23.
2004: Tadashi Kohyama; Xiangde Liu; Fu-Qiang Wen; Tetsu Kobayashi; Shinji Abe; Stephen I Rennard
IL-4 and IL-13 induce chemotaxis of human foreskin fibroblasts, but not human fetal lung fibroblasts.
Inflammation 2004;28(1):33-7.
2003: Hajime Takizawa; Shinji Abe; Hitoshi Okazaki; Tadashi Kohyama; Isamu Sugawara; Yoshinobu Saito; Takayuki Ohtoshi; Shin Kawasaki; Masashi Desaki; Kazuhiko Nakahara; Kazuhiko Yamamoto; Kouji Matsushima; Mitsuru Tanaka; Masaru Sagai; Shoji Kudoh
Diesel exhaust particles upregulate eotaxin gene expression in human bronchial epithelial cells via nuclear factor-kappa B-dependent pathway.
American journal of physiology. Lung cellular and molecular physiology 2003;284(6):L1055-62.
2003: Xiangde Liu; Tadashi Kohyama; Tetsu Kobayashi; Shinji Abe; Hui Jung Kim; Elizabeth C Reed; Stephen I Rennard
Cigarette smoke extract inhibits chemotaxis and collagen gel contraction mediated by human bone marrow osteoprogenitor cells and osteoblast-like cells.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2003;14(3):235-42.
2003: Fu-Qiang Wen; Tadashi Kohyama; C Magnus Sköld; Yun Kui Zhu; Xiangde Liu; Debra J Romberger; Julie A Stoner; Stephen I Rennard
Glucocorticoids modulate TGF-beta production by human fetal lung fibroblasts.
Inflammation 2003;27(1):9-19.
2003: Huijung Kim; Xiangde Liu; Tetsu Kobayashi; Tadashi Kohyama; Fu-Qiang Wen; Debra J Romberger; Heather Conner; Peter S Gilmour; Kenneth Donaldson; William MacNee; Stephen I Rennard
Ultrafine carbon black particles inhibit human lung fibroblast-mediated collagen gel contraction.
American journal of respiratory cell and molecular biology 2003;28(1):111-21.
2003: Hangjun Wang; Xiangde Liu; Takeshi Umino; Tadashi Kohyama; Yun Kui Zhu; Fu-Qiang Wen; John R Spurzem; Debra J Romberger; Hui Jung Kim; Stephen I Rennard
Effect of cigarette smoke on fibroblast-mediated gel contraction is dependent on cell density.
American journal of physiology. Lung cellular and molecular physiology 2003;284(1):L205-13.
2002: Fu-Qiang Wen; Tadashi Kohyama; C Magnus Sköld; Yun Kui Zhu; Xiangde Liu; Debra J Romberger; Julie A Stoner; Stephen I Rennard
Glucocorticoids modulate TGF-beta production.
Inflammation 2002;26(6):279-90.
2002: Tadashi Kohyama; Xiangde Liu; Fu-Qiang Wen; Tetsu Kobayashi; Shinji Abe; Ronald F Ertl; Stephen I Rennard
Nerve growth factor stimulates fibronectin-induced fibroblast migration.
The Journal of laboratory and clinical medicine 2002;140(5):329-35.
2002: Tadashi Kohyama; Xiangde Liu; Yun Kui Zhu; Fu-Qiang Wen; Hang Jun Wang; Qiuhong Fang; Tetsu Kobayashi; Stephen I Rennard
Phosphodiesterase 4 inhibitor cilomilast inhibits fibroblast-mediated collagen gel degradation induced by tumor necrosis factor-alpha and neutrophil elastase.
American journal of respiratory cell and molecular biology 2002;27(4):487-94.
2002: Tadashi Kohyama; Todd A Wyatt; Xiangde Liu; Fu-Qiang Wen; Tetsu Kobayashi; Qiuhong Fang; Hui Jung Kim; Stephen I Rennard
PGD(2) modulates fibroblast-mediated native collagen gel contraction.
American journal of respiratory cell and molecular biology 2002;27(3):375-81.
2002: Tadashi Kohyama; Xiangde Liu; Hui Jung Kim; Tetsu Kobayashi; Ronald F Ertl; Fu-Qiang Wen; Hajime Takizawa; Stephen I Rennard
Prostacyclin analogs inhibit fibroblast migration.
American journal of physiology. Lung cellular and molecular physiology 2002;283(2):L428-32.
2002: Hui Jung Kim; Xiangde Liu; Hangjun Wang; Tadashi Kohyama; Tetsu Kobayashi; Fu-Qiang Wen; Debra J Romberger; Shinji Abe; William MacNee; Irfan Rahman; Stephen I Rennard
Glutathione prevents inhibition of fibroblast-mediated collagen gel contraction by cigarette smoke.
American journal of physiology. Lung cellular and molecular physiology 2002;283(2):L409-17.
2002: Tadashi Kohyama; Xiangde Liu; Fu-Qiang Wen; Yun Kui Zhu; Hangjun Wang; Hui Jung Kim; Hajime Takizawa; Lenora B Cieslinski; Mary S Barnette; Stephen I Rennard
PDE4 inhibitors attenuate fibroblast chemotaxis and contraction of native collagen gels.
American journal of respiratory cell and molecular biology 2002;26(6):694-701.
2002: Xiangde Liu; Tadashi Kohyama; Hangjun Wang; Yun Kui Zhu; Fu-Qiang Wen; Hui Jung Kim; Debra J Romberger; Stephen I Rennard
Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cells.
American journal of physiology. Lung cellular and molecular physiology 2002;282(5):L1049-56.
2002: Tadashi Kohyama; X D Liu; Fu-Qiang Wen; Hui Jung Kim; H Takizawa; Stephen I Rennard
Prostaglandin D2 inhibits fibroblast migration.
The European respiratory journal 2002;19(4):684-9.
2002: Fu-Qiang Wen; Tadashi Kohyama; Xiangde Liu; Yun Kui Zhu; Hangjun Wang; Hui Jun Kim; Tetsu Kobayashi; Shinji Abe; John R Spurzem; Stephen I Rennard
Interleukin-4- and interleukin-13-enhanced transforming growth factor-beta2 production in cultured human bronchial epithelial cells is attenuated by interferon-gamma.
American journal of respiratory cell and molecular biology 2002;26(4):484-90.
2002: Tadashi Kohyama; Xiangde Liu; Fu-Qiang Wen; H J Kim; H Takizawa; Stephen I Rennard
Potentiation of human lung fibroblast chemotaxis by the thromboxane A(2) analog U-46619.
The Journal of laboratory and clinical medicine 2002;139(1):43-9.
2001: Yun Kui Zhu; X Liu; H Wang; Tadashi Kohyama; Fu-Qiang Wen; C Magnus Sköld; Stephen I Rennard
Interactions between monocytes and smooth-muscle cells can lead to extracellular matrix degradation.
The Journal of allergy and clinical immunology 2001;108(6):989-96.
2001: H Wang; Xiangde Liu; Takeshi Umino; C M Sköld; Y Zhu; Tadashi Kohyama; John R Spurzem; Debra J Romberger; Stephen I Rennard
Cigarette smoke inhibits human bronchial epithelial cell repair processes.
American journal of respiratory cell and molecular biology 2001;25(6):772-9.
2001: Yun Kui Zhu; Xiangde Liu; Ronald F Ertl; Tadashi Kohyama; Fu-Qiang Wen; Hangjun Wang; John R Spurzem; Debra J Romberger; Stephen I Rennard
Retinoic acid attenuates cytokine-driven fibroblast degradation of extracellular matrix in three-dimensional culture.
American journal of respiratory cell and molecular biology 2001;25(5):620-7.
2001: Tadashi Kohyama; Ronald F Ertl; Vincenzo Valenti; John R Spurzem; M Kawamoto; Y Nakamura; Tom Veys; L Allegra; Debra V Romberger; Stephen I Rennard
Prostaglandin E(2) inhibits fibroblast chemotaxis.
American journal of physiology. Lung cellular and molecular physiology 2001;281(5):L1257-63.
2001: Yun Kui Zhu; Xiangde D Liu; C Magnus Sköld; Takeshi Umino; H J Wang; John R Spurzem; Tadashi Kohyama; Ronald F Ertl; Stephen I Rennard
Synergistic neutrophil elastase-cytokine interaction degrades collagen in three-dimensional culture.
American journal of physiology. Lung cellular and molecular physiology 2001;281(4):L868-78.
2001: Yun Kui Zhu; X D Liu; M C Sköld; Takeshi Umino; H Wang; Debra J Romberger; John R Spurzem; Tadashi Kohyama; Fu-Qiang Wen; Stephen I Rennard
Cytokine inhibition of fibroblast-induced gel contraction is mediated by PGE(2) and NO acting through separate parallel pathways.
American journal of respiratory cell and molecular biology 2001;25(2):245-53.
2001: Fu-Qiang Wen; C Magnus Sköld; Xiangde D Liu; Ronald F Ertl; Yun Kui Zhu; Tadashi Kohyama; Hangjun Wang; Stephen I Rennard
Glucocorticoids and TGF-beta1 synergize in augmenting fibroblast mediated contraction of collagen gels.
Inflammation 2001;25(2):109-17.
2001: Xiangde D Liu; Takeshi Umino; Ronald F Ertl; Tom Veys; CM Skold; K Takigawa; Debra J Romberger; John R Spurzem; Yun Kui Zhu; Tadashi Kohyama; Hangjun Wang; Stephen I Rennard
Persistence of TGF-beta1 induction of increased fibroblast contractility.
In vitro cellular & developmental biology. Animal 2001;37(3):193-201.
2001: Y Zhu; Xiangde Liu; C Magnus Sköld; Hangjun Wang; Tadashi Kohyama; Fu-Qiang Wen; Ronald F Ertl; Stephen I Rennard
Collaborative interactions between neutrophil elastase and metalloproteinases in extracellular matrix degradation in three-dimensional collagen gels.
Respiratory research 2001;2(5):300-5.
2001: Y Zhu; C Magnus Sköld; Xiangde Liu; Hangjun Wang; Tadashi Kohyama; Fu-Qiang Wen; Ronald F Ertl; Stephen I Rennard
Fibroblasts and monocyte macrophages contract and degrade three-dimensional collagen gels in extended co-culture.
Respiratory research 2001;2(5):295-9.
1999: Hajime Takizawa; Takayuki Ohtoshi; Shin Kawasaki; Tadashi Kohyama; Masashi Desaki; T Kasama; Kazuhiro Kobayashi; Kazuhiko Nakahara; Kazuhiko Yamamoto; Kouji Matsushima; Shoji Kudoh
Diesel exhaust particles induce NF-kappa B activation in human bronchial epithelial cells in vitro: importance in cytokine transcription.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4705-11.
1999: Tadashi Kohyama; Hajime Takizawa; Shin Kawasaki; N Akiyama; M Sato; Kousei Ito; Kazuhiko Yamamoto
A potent immunosuppressant FK506 inhibits IL-8 expression in human eosinophils.
Molecular cell biology research communications : MCBRC 1999;1(1):72-7.
1999: Tadashi Kohyama; Hajime Takizawa; Shin Kawasaki; N Akiyama; M Sato; Kousei Ito
Fourteen-member macrolides inhibit interleukin-8 release by human eosinophils from atopic donors.
Antimicrobial agents and chemotherapy 1999;43(4):907-11.
1998: Hajime Takizawa; Masashi Desaki; Takayuki Ohtoshi; Shin Kawasaki; Tadashi Kohyama; M Sato; J Nakajima; M Yanagisawa; Kousei Ito
Erythromycin and clarithromycin attenuate cytokine-induced endothelin-1 expression in human bronchial epithelial cells.
The European respiratory journal 1998;12(1):57-63.
1998: Shin Kawasaki; Hajime Takizawa; Takayuki Ohtoshi; N Takeuchi; Tadashi Kohyama; H Nakamura; T Kasama; Kazuhiro Kobayashi; Kazuhiko Nakahara; Yutaka Morita; Kazuhiko Yamamoto
Roxithromycin inhibits cytokine production by and neutrophil attachment to human bronchial epithelial cells in vitro.
Antimicrobial agents and chemotherapy 1998;42(6):1499-502.
1997: Hajime Takizawa; Masashi Desaki; Takayuki Ohtoshi; Shin Kawasaki; Tadashi Kohyama; M Sato; Mitsuru Tanaka; T Kasama; Kazuhiro Kobayashi; J Nakajima; Kousei Ito
Erythromycin modulates IL-8 expression in normal and inflamed human bronchial epithelial cells.
American journal of respiratory and critical care medicine 1997;156(1):266-71.
1997: M Sato; Hajime Takizawa; Tadashi Kohyama; Takayuki Ohtoshi; S Takafuji; S Kawasaki; Shigeto Tohma; A Ishii; Shin'ichi Shoji; Kousei Ito
Eosinophil adhesion to human bronchial epithelial cells: regulation by cytokines.
International archives of allergy and immunology 1997;113(1-3):203-5.
1997: Tadashi Kohyama; Hajime Takizawa; N Akiyama; Masamitsu Sato; Shin Kawasaki; Kousei Ito
A novel antiallergic drug epinastine inhibits IL-8 release from human eosinophils.
Biochemical and biophysical research communications 1997;230(1):125-8.
1996: Hajime Takizawa; N Suzuki; T Yanagawa; H Okazaki; M Satoh; N Akiyama; Tadashi Kohyama; K Ito; T Oka
[Importance of interstitial lung disease in collagen vascular disease: analysis of outcome].
Nihon Kyōbu Shikkan Gakkai zasshi 1996;34(11):1177-81.
1996: Hajime Takizawa; N Suzuki; T Yanagawa; H Okazaki; M Satoh; N Akiyama; Tadashi Kohyama; S Kawasaki; K Ito; T Oka
[Outcome in patients with interstitial lung disease and polymyositis-dermatomyositis--a subgroup with poor prognosis].
Nihon Kyōbu Shikkan Gakkai zasshi 1996;34(10):1093-7.
1995: Hajime Takizawa; N Suzuki; T Yanagawa; H Okazaki; M Satoh; N Akiyama; Tadashi Kohyama; K Ito; T Oka; K Hayakawa
[Pulmonary involvement of collagen vascular diseases: studies on prognostic factors from basic and clinical viewpoints].
Nihon Kyōbu Shikkan Gakkai zasshi 1995;33 Suppl():291-5.