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Osamu Koiwai

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Takuro Matsumoto; Masahiro Suzuki; So Maezawa; Kaori Go; Takahide Hayano; Mariko Hyodo; Kotaro Koiwai; Osamu Koiwai
BRCT domain of DNA polymerase μ has DNA-binding activity and promotes the DNA polymerization activity.
So Maezawa; Takuro Matsumoto; Toyofumi Matsushita; Yoshihiro Nishiyama; Masahiro Suzuki; Yoshiki Takagaki; Sachiko Ando; Rie Fukushima; Takahide Hayano; Tomoyoshi Kato; Kotaro Koiwai; Kousuke Kouda; Osamu Koiwai
Ubiquitylation of terminal deoxynucleotidyltransferase inhibits its activity.
Kotaro Koiwai; Masaki Furuichi; Takahide Hayano; Kousuke Kouda; So Maezawa; Takuro Matsumoto; Satoshi Noma; Masahiro Suzuki; Yasuhiro Takahashi; Osamu Koiwai
TdIF2 is a nucleolar protein that promotes rRNA gene promoter activity.

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2012: Takuro Matsumoto; Masahiro Suzuki; So Maezawa; Kaori Go; Takahide Hayano; Mariko Hyodo; Kotaro Koiwai; Osamu Koiwai
BRCT domain of DNA polymerase μ has DNA-binding activity and promotes the DNA polymerization activity.
Genes to cells : devoted to molecular & cellular mechanisms 2012;17(9):790-806.
2012: So Maezawa; Takuro Matsumoto; Toyofumi Matsushita; Yoshihiro Nishiyama; Masahiro Suzuki; Yoshiki Takagaki; Sachiko Ando; Rie Fukushima; Takahide Hayano; Tomoyoshi Kato; Kotaro Koiwai; Kousuke Kouda; Osamu Koiwai
Ubiquitylation of terminal deoxynucleotidyltransferase inhibits its activity.
PloS one 2012;7(7):e39511.
2011: Kotaro Koiwai; Masaki Furuichi; Takahide Hayano; Kousuke Kouda; So Maezawa; Takuro Matsumoto; Satoshi Noma; Masahiro Suzuki; Yasuhiro Takahashi; Osamu Koiwai
TdIF2 is a nucleolar protein that promotes rRNA gene promoter activity.
Genes to cells : devoted to molecular & cellular mechanisms 2011;16(7):748-64.
2009: Takahide Hayano; Kotaro Koiwai; Hisataka Ishii; So Maezawa; Kousuke Kouda; Takuro Motoyama; Takashi Kubota; Osamu Koiwai
TdT interacting factor 1 enhances TdT ubiquitylation through recruitment of BPOZ-2 into nucleus from cytoplasm.
Genes to cells : devoted to molecular & cellular mechanisms 2009;14(12):1415-27.
2008: Kotaro Koiwai; So Maezawa; Takahide Hayano; Michiko Iitsuka; Osamu Koiwai
BPOZ-2 directly binds to eEF1A1 to promote eEF1A1 ubiquitylation and degradation and prevent translation.
Genes to cells : devoted to molecular & cellular mechanisms 2008;13(6):593-607.
2008: So Maezawa; Takahide Hayano; Kotaro Koiwai; Rie Fukushima; Kousuke Kouda; Takashi Kubota; Osamu Koiwai
Bood POZ containing gene type 2 is a human counterpart of yeast Btb3p and promotes the degradation of terminal deoxynucleotidyltransferase.
Genes to cells : devoted to molecular & cellular mechanisms 2008;13(5):439-57.
2008: Emi Akizawa; Kotaro Koiwai; Takahide Hayano; So Maezawa; Toyofumi Matsushita; Osamu Koiwai
Direct binding of ligandin to uridine 5'-diphosphate glucuronosyltransferase 1A1.
Hepatology research : the official journal of the Japan Society of Hepatology 2008;38(4):402-9.
2007: Takashi Kubota; So Maezawa; Kotaro Koiwai; Takahide Hayano; Osamu Koiwai
Identification of functional domains in TdIF1 and its inhibitory mechanism for TdT activity.
Genes to cells : devoted to molecular & cellular mechanisms 2007;12(8):941-59.
2007: Chisato Ishimaru; Isoko Kuriyama; Noriko Shimazaki; Osamu Koiwai; Kengo Sakaguchi; Ikuo Kato; Hiromi Yoshida; Yoshiyuki Mizushina
Cholesterol hemisuccinate: a selective inhibitor of family X DNA polymerases.
Biochemical and biophysical research communications 2007;354(2):619-25.
2006: Yoshiyuki Mizushina; Rumi Nakanishi; Isoko Kuriyama; Kohei Kamiya; Toshiko Satake; Noriko Shimazaki; Osamu Koiwai; Yukinobu Uchiyama; Yuko Yonezawa; Masaharu Takemura; Kengo Sakaguchi; Hiromi Yoshida
Beta-sitosterol-3-O-beta-D-glucopyranoside: a eukaryotic DNA polymerase lambda inhibitor.
The Journal of steroid biochemistry and molecular biology 2006;99(2-3):100-7.
2006: Toshifumi Takeuchi; Tomomi Ishidoh; Hiroshi Iijima; Isoko Kuriyama; Noriko Shimazaki; Osamu Koiwai; Kouji Kuramochi; Susumu Kobayashi; Fumio Sugawara; Kengo Sakaguchi; Hiromi Yoshida; Yoshiyuki Mizushina
Structural relationship of curcumin derivatives binding to the BRCT domain of human DNA polymerase lambda.
Genes to cells : devoted to molecular & cellular mechanisms 2006;11(3):223-35.
2006: Yoshiyuki Mizushina; Etsuko Yagita; Kouji Kuramochi; Isoko Kuriyama; Noriko Shimazaki; Osamu Koiwai; Yukinobu Uchiyama; Yuko Yomezawa; Fumio Sugawara; Susumu Kobayashi; Kengo Sakaguchi; Hiromi Yoshida
5-(Hydroxymethyl)-2-furfural: a selective inhibitor of DNA polymerase lambda and terminal deoxynucleotidyltransferase.
Archives of biochemistry and biophysics 2006;446(1):69-76.
2006: Yoshiyuki Mizushina; Kiyotaka Nakagawa; Akira Shibata; Yasutoshi Awata; Isoko Kuriyama; Noriko Shimazaki; Osamu Koiwai; Yukinobu Uchiyama; Kengo Sakaguchi; Teruo Miyazawa; Hiromi Yoshida
Inhibitory effect of tocotrienol on eukaryotic DNA polymerase lambda and angiogenesis.
Biochemical and biophysical research communications 2006;339(3):949-55.
2006: Seiichiro Fujisaki; Asami Sato; Tsuguri Toyomoto; Takahide Hayano; Maki Sugai; Takashi Kubota; Osamu Koiwai
Direct binding of TReP-132 with TdT results in reduction of TdT activity.
Genes to cells : devoted to molecular & cellular mechanisms 2006;11(1):47-57.
2005: Yoshiyuki Mizushina; Tomomi Ishidoh; Toshifumi Takeuchi; Noriko Shimazaki; Osamu Koiwai; Kouji Kuramochi; Susumu Kobayashi; Fumio Sugawara; Kengo Sakaguchi; Hiromi Yoshida
Monoacetylcurcumin: a new inhibitor of eukaryotic DNA polymerase lambda and a new ligand for inhibitor-affinity chromatography.
Biochemical and biophysical research communications 2005;337(4):1288-95.
2005: Yukinobu Uchiyama; Junko Tagami; Shinji Kamisuki; Nobuyuki Kasai; Masahiko Oshige; Hiroyuki Chiku; Siroh Ibe; Osamu Koiwai; Fumio Sugawara; Kengo Sakaguchi
Selective inhibitors of terminal deoxyribonucleotidyltransferase (TdT): baicalin and genistin.
Biochimica et biophysica acta 2005;1725(3):298-304.
2005: Ryosuke Watanabe; Tokuhiro Chano; Hirokazu Inoue; Takahiro Isono; Osamu Koiwai; Hidetoshi Okabe
Rb1cc1 is critical for myoblast differentiation through Rb1 regulation.
Virchows Archiv : an international journal of pathology 2005;447(3):643-8.
2005: Noriko Shimazaki; Takaya Yazaki; Takashi Kubota; Asami Sato; Ayako Nakamura; Shunsuke Kurei; Shingo Toji; Katsuyuki Tamai; Osamu Koiwai
DNA polymerase lambda directly binds to proliferating cell nuclear antigen through its confined C-terminal region.
Genes to cells : devoted to molecular & cellular mechanisms 2005;10(7):705-15.
2005: Yoshiyuki Mizushina; Kouji Kuramochi; Hiroshi Ikawa; Isoko Kuriyama; Noriko Shimazaki; Masaharu Takemura; Masahiko Oshige; Hiromi Yoshida; Osamu Koiwai; Fumio Sugawara; Susumu Kobayashi; Kengo Sakaguchi
Structural analysis of epolactaene derivatives as DNA polymerase inhibitors and anti-inflammatory compounds.
International journal of molecular medicine 2005;15(5):785-93.
2005: Yuko Ohta; Shintaro Fukushima; Nobuyuki Yamashita; Tomoko Niimi; Takashi Kubota; Emi Akizawa; Osamu Koiwai
UDP-glucuronosyltransferase1A1 directly binds to albumin.
Hepatology research : the official journal of the Japan Society of Hepatology 2005;31(4):241-5.
2004: Yunmei Ma; Haihui Lu; Brigette Tippin; Myron F Goodman; Noriko Shimazaki; Osamu Koiwai; Chih-Lin Hsieh; Klaus Schwarz; Michael R Lieber
A biochemically defined system for mammalian nonhomologous DNA end joining.
Molecular cell 2004;16(5):701-13.
2003: Yoshiyuki Mizushina; Mitsuru Hirota; Chikako Murakami; Tomomi Ishidoh; Shinji Kamisuki; Noriko Shimazaki; Masaharu Takemura; Marinela Perpelescu; Motoshi Suzuki; Hiromi Yoshida; Fumio Sugawara; Osamu Koiwai; Kengo Sakaguchi
Some anti-chronic inflammatory compounds are DNA polymerase lambda-specific inhibitors.
Biochemical pharmacology 2003;66(10):1935-44.
2003: Kiyoko Fujita; Noriko Shimazaki; Yuko Ohta; Takashi Kubota; Siroh Ibe; Shingo Toji; Katsuyuki Tamai; Seiichiro Fujisaki; Takahide Hayano; Osamu Koiwai
Terminal deoxynucleotidyltransferase forms a ternary complex with a novel chromatin remodeling protein with 82 kDa and core histone.
Genes to cells : devoted to molecular & cellular mechanisms 2003;8(6):559-71.
2003: Yoshiyuki Mizushina; Chikako Murakami; Hirosato Takikawa; Nobuyuki Kasai; Xianai Xu; Kenji Mori; Masahiko Oshige; Toyofumi Yamaguchi; Mineo Saneyoshi; Noriko Shimazaki; Osamu Koiwai; Hiromi Yoshida; Fumio Sugawara; Kengo Sakaguchi
Molecular action mode of Hippospongic acid A, an inhibitor of gastrulation of starfish embryos.
Journal of biochemistry 2003;133(4):541-52.
2003: Yoshiyuki Mizushina; Xianai Xu; Hitomi Asahara; Ryo Takeuchi; Masahiko Oshige; Noriko Shimazaki; Masaharu Takemura; Toyofumi Yamaguchi; Kazufumi Kuroda; Stuart Linn; Hiromi Yoshida; Osamu Koiwai; Mineo Saneyoshi; Fumio Sugawara; Kengo Sakaguchi
A sulphoquinovosyl diacylglycerol is a DNA polymerase epsilon inhibitor.
The Biochemical journal 2003;370(Pt 1):299-305.
2002: Yoshiyuki Mizushina; Shinji Kamisuki; Nobuyuki Kasai; Tomomi Ishidoh; Noriko Shimazaki; Masaharu Takemura; Hitomi Asahara; Stuart Linn; Shonen Yoshida; Osamu Koiwai; Fumio Sugawara; Hiromi Yoshida; Kengo Sakaguchi
Petasiphenol: a DNA polymerase lambda inhibitor.
Biochemistry 2002;41(49):14463-71.
2002: Noriko Shimazaki; Kenta Yoshida; Toshiko Kobayashi; Shingo Toji; Katsuyuki Tamai; Osamu Koiwai
Over-expression of human DNA polymerase lambda in E. coli and characterization of the recombinant enzyme.
Genes to cells : devoted to molecular & cellular mechanisms 2002;7(7):639-51.
2002: Noriko Shimazaki; Kiyoko Fujita; Osamu Koiwai
[Expression and function of terminal deoxynucleotidyl-transferase and discovery of novel DNA polymerase mu].
Seikagaku. The Journal of Japanese Biochemical Society 2002;74(3):227-32.
2002: Yoshiyuki Mizushina; Shinji Kamisuki; Nobuyuki Kasai; Noriko Shimazaki; Masaharu Takemura; Hitomi Asahara; Stuart Linn; Shonen Yoshida; Akio Matsukage; Osamu Koiwai; Fumio Sugawara; Hiromi Yoshida; Kengo Sakaguchi
A plant phytotoxin, solanapyrone A, is an inhibitor of DNA polymerase beta and lambda.
The Journal of biological chemistry 2002;277(1):630-8.
2001: Kei-ichi Takata; Hiromi Yoshida; Fumiko Hirose; Masamitsu Yamaguchi; Mihoko Kai; Masahiko Oshige; I Sakimoto; Osamu Koiwai; Kengo Sakaguchi
Drosophila mitochondrial transcription factor A: characterization of its cDNA and expression pattern during development.
Biochemical and biophysical research communications 2001;287(2):474-83.
2001: Siroh Ibe; Kiyoko Fujita; Tsuguri Toyomoto; Noriko Shimazaki; R Kaneko; A Tanabe; I Takebe; S Kuroda; T Kobayashi; Shingo Toji; Katsuyuki Tamai; H Yamamoto; Osamu Koiwai
Terminal deoxynucleotidyltransferase is negatively regulated by direct interaction with proliferating cell nuclear antigen.
Genes to cells : devoted to molecular & cellular mechanisms 2001;6(9):815-24.
2001: N Yamashita; Noriko Shimazaki; Siroh Ibe; R Kaneko; A Tanabe; Tsuguri Toyomoto; Kiyoko Fujita; T Hasegawa; Shingo Toji; Katsuyuki Tamai; H Yamamoto; Osamu Koiwai
Terminal deoxynucleotidyltransferase directly interacts with a novel nuclear protein that is homologous to p65.
Genes to cells : devoted to molecular & cellular mechanisms 2001;6(7):641-52.
2000: Masahiko Oshige; Hiromi Yoshida; Fumiko Hirose; Kei-ichi Takata; Y Inoue; N Aoyagi; M Yamaguchi; Osamu Koiwai; Akio Matsukage; Kengo Sakaguchi
Molecular cloning and expression during development of the Drosophila gene for the catalytic subunit of DNA polymerase epsilon.
Gene 2000;256(1-2):93-100.