Merab Kokaia

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M V Olesen; S H Christiansen; C R Gøtzsche; B Holst; M Kokaia; D P D Woldbye
Y5 neuropeptide Y receptor overexpression in mice neither affects anxiety- and depression-like behaviours nor seizures but confers moderate hyperactivity.
Casper R Gøtzsche; Litsa Nikitidou; Andreas T Sørensen; Mikkel V Olesen; Gunnar Sørensen; Søren H O Christiansen; Mikael Ängehagen; David P D Woldbye; Merab Kokaia
Combined gene overexpression of neuropeptide Y and its receptor Y5 in the hippocampus suppresses seizures.
Merab Kokaia
Light-activated channels in acute seizures.

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All Publications

2012: M V Olesen; S H Christiansen; C R Gøtzsche; B Holst; M Kokaia; D P D Woldbye
Y5 neuropeptide Y receptor overexpression in mice neither affects anxiety- and depression-like behaviours nor seizures but confers moderate hyperactivity.
Neuropeptides 2012;46(2):71-9.
2012: Casper R Gøtzsche; Litsa Nikitidou; Andreas T Sørensen; Mikkel V Olesen; Gunnar Sørensen; Søren H O Christiansen; Mikael Ängehagen; David P D Woldbye; Merab Kokaia
Combined gene overexpression of neuropeptide Y and its receptor Y5 in the hippocampus suppresses seizures.
Neurobiology of disease 2012;45(1):288-96.
2011: Merab Kokaia
Light-activated channels in acute seizures.
Epilepsia 2011;52 Suppl 8():16-8.
2011: James C Wood; Johanna S Jackson; Katherine Jakubs; Katie Z Chapman; Christine T Ekdahl; Zaal Kokaia; Merab Kokaia; Olle Lindvall
Functional integration of new hippocampal neurons following insults to the adult brain is determined by characteristics of pathological environment.
Experimental neurology 2011;229(2):484-93.
2011: Andreas Toft Sørensen; Nina Rogelius; Cecilia Lundberg; Merab Kokaia
Activity-dependent long-term plasticity of afferent synapses on grafted stem/progenitor cell-derived neurons.
Experimental neurology 2011;229(2):274-81.
2011: Merab Kokaia
Seizure-induced neurogenesis in the adult brain.
The European journal of neuroscience 2011;33(6):1133-8.
2011: Marco Ledri; Andreas Toft Sørensen; Ferenc Erdelyi; Gabor Szabo; Merab Kokaia
Tuning afferent synapses of hippocampal interneurons by neuropeptide Y.
Hippocampus 2011;21(2):198-211.
2011: Jan Tønnesen; Clare L Parish; Andreas T Sørensen; Angelica Andersson; Cecilia Lundberg; Karl Deisseroth; Ernest Arenas; Olle Lindvall; Merab Kokaia
Functional integration of grafted neural stem cell-derived dopaminergic neurons monitored by optogenetics in an in vitro Parkinson model.
PloS one 2011;6(3):e17560.
2011: M Kokaia; A T Sørensen
The treatment of neurological diseases under a new light: the importance of optogenetics.
Drugs of today (Barcelona, Spain : 1998) 2011;47(1):53-62.
2010: David P D Woldbye; Mikael Angehagen; Casper R Gøtzsche; Heidi Elbrønd-Bek; Andreas T Sørensen; Søren H Christiansen; Mikkel V Olesen; Litsa Nikitidou; Thomas V O Hansen; Irene Kanter-Schlifke; et al.
Adeno-associated viral vector-induced overexpression of neuropeptide Y Y2 receptors in the hippocampus suppresses seizures.
Brain : a journal of neurology 2010;133(9):2778-88.
2010: Jan Tønnesen; Emma Gonzalez Seiz; Milagros Ramos; Olle Lindvall; Alberto Martinez-Serrano; Merab Kokaia
Functional properties of the human ventral mesencephalic neural stem cell line hVM1.
Experimental neurology 2010;223(2):653-6.
2009: Merab Kokaia
Novel perspectives in treatment of epilepsy.
Epilepsy research 2009;85(2-3):129-30.
2009: Jan Tønnesen; Andreas T Sørensen; Karl Deisseroth; Cecilia Lundberg; Merab Kokaia
Optogenetic control of epileptiform activity.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(29):12162-7.
2009: Henrik Ahlenius; Violeta Visan; Merab Kokaia; Olle Lindvall; Zaal Kokaia
Neural stem and progenitor cells retain their potential for proliferation and differentiation into functional neurons despite lower number in aged brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(14):4408-19.
2009: Irene Kanter-Schlifke; Lone Fjord-Larsen; Philip Kusk; Mikael Angehagen; Lars Wahlberg; Merab Kokaia
GDNF released from encapsulated cells suppresses seizure activity in the epileptic hippocampus.
Experimental neurology 2009;216(2):413-9.
2009: Andreas T Sørensen; Litsa Nikitidou; Marco Ledri; En-Ju D Lin; Matthew J During; Irene Kanter-Schlifke; Merab Kokaia
Hippocampal NPY gene transfer attenuates seizures without affecting epilepsy-induced impairment of LTP.
Experimental neurology 2009;215(2):328-33.
2008: Katherine Jakubs; Sara Bonde; Robert E Iosif; Christine T Ekdahl; Zaal Kokaia; Merab Kokaia; Olle Lindvall
Inflammation regulates functional integration of neurons born in adult brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(47):12477-88.
2008: Andreas T Sørensen; Irene Kanter-Schlifke; En-Ju D Lin; Matthew J During; Merab Kokaia
Activity-dependent volume transmission by transgene NPY attenuates glutamate release and LTP in the subiculum.
Molecular and cellular neurosciences 2008;39(2):229-37.
2008: Andreas T Sørensen; Irene Kanter-Schlifke; Mirjana Carli; Claudia Balducci; Francesco Noe; Matthew J During; Annamaria Vezzani; Merab Kokaia
NPY gene transfer in the hippocampus attenuates synaptic plasticity and learning.
Hippocampus 2008;18(6):564-74.
2008: Clare L Parish; Gonçalo Castelo-Branco; Nina Rawal; Jan Tonnesen; Andreas Toft Sorensen; Carmen Salto; Merab Kokaia; Olle Lindvall; Ernest Arenas
Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice.
The Journal of clinical investigation 2008;118(1):149-60.
2007: I Kanter-Schlifke; A Toft Sørensen; M Ledri; E Kuteeva; T Hökfelt; M Kokaia
Galanin gene transfer curtails generalized seizures in kindled rats without altering hippocampal synaptic plasticity.
Neuroscience 2007;150(4):984-92.
2007: Irene Kanter-Schlifke; Biljana Georgievska; Deniz Kirik; Merab Kokaia
Brain area, age and viral vector-specific glial cell-line-derived neurotrophic factor expression and transport in rat.
Neuroreport 2007;18(9):845-50.
2007: Irene Kanter-Schlifke; Biljana Georgievska; Deniz Kirik; Merab Kokaia
Seizure suppression by GDNF gene therapy in animal models of epilepsy.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(6):1106-13.
2006: Katherine Jakubs; Avtandil Nanobashvili; Sara Bonde; Christine T Ekdahl; Zaal Kokaia; Merab Kokaia; Olle Lindvall
Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability.
Neuron 2006;52(6):1047-59.
2006: Michele Simonato; Enrico Tongiorgi; Merab Kokaia
Angels and demons: neurotrophic factors and epilepsy.
Trends in pharmacological sciences 2006;27(12):631-8.
2006: Josefine Nygren; Merab Kokaia; Tadeusz Wieloch
Decreased expression of brain-derived neurotrophic factor in BDNF(+/-) mice is associated with enhanced recovery of motor performance and increased neuroblast number following experimental stroke.
Journal of neuroscience research 2006;84(3):626-31.
2006: Irene Schlifke; Eugenia Kuteeva; Tomas Hokfelt; Merab Kokaia
Galanin expressed in the excitatory fibers attenuates synaptic strength and generalized seizures in the piriform cortex of mice.
Experimental neurology 2006;200(2):398-406.
2005: David P D Woldbye; Avtandil Nanobashvili; Andreas T Sørensen; Henriette Husum; Tom G Bolwig; Gunnar Sørensen; Patrik Ernfors; Merab Kokaia
Differential suppression of seizures via Y2 and Y5 neuropeptide Y receptors.
Neurobiology of disease 2005;20(3):760-72.
2005: Avtandil Nanobashvili; Katherine Jakubs; Merab Kokaia
Chronic BDNF deficiency permanently modifies excitatory synapses in the piriform cortex.
Journal of neuroscience research 2005;81(5):696-705.
2005: Paul Mohapel; Giampiero Leanza; Merab Kokaia; Olle Lindvall
Forebrain acetylcholine regulates adult hippocampal neurogenesis and learning.
Neurobiology of aging 2005;26(6):939-46.
2005: Andreas Toft Sørensen; Lachlan Thompson; Deniz Kirik; Anders Björklund; Olle Lindvall; Merab Kokaia
Functional properties and synaptic integration of genetically labelled dopaminergic neurons in intrastriatal grafts.
The European journal of neuroscience 2005;21(10):2793-9.
2004: D P D Woldbye; M Kokaia
Neuropeptide Y and seizures: effects of exogenously applied ligands.
Neuropeptides 2004;38(4):253-60.
2004: Avtandil Nanobashvili; David P D Woldbye; Henriette Husum; Tom G Bolwig; Merab Kokaia
Neuropeptide Y Y5 receptors suppress in vitro spontaneous epileptiform bursting in the rat hippocampus.
Neuroreport 2004;15(2):339-43.
2003: Tengis Gloveli; Joachim Behr; Tamar Dugladze; Zaal Kokaia; Merab Kokaia; Uwe Heinemann
Kindling alters entorhinal cortex-hippocampal interaction by increased efficacy of presynaptic GABA(B) autoreceptors in layer III of the entorhinal cortex.
Neurobiology of disease 2003;13(3):203-12.
2002: Ulrica Englund; Anders Bjorklund; Klas Wictorin; Olle Lindvall; Merab Kokaia
Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(26):17089-94.
2002: D P D Woldbye; A Nanobashvili; H Husum; T G Bolwig; M Kokaia
Neuropeptide Y inhibits in vitro epileptiform activity in the entorhinal cortex of mice.
Neuroscience letters 2002;333(2):127-30.
2001: Z Kokaia; M Kokaia
Changes in GABA(B) receptor immunoreactivity after recurrent seizures in rats.
Neuroscience letters 2001;315(1-2):85-8.
2001: M Kokaia; K Holmberg; A Nanobashvili; Z Q Xu; Z Kokaia; U Lendahl; S Hilke; E Theodorsson; U Kahl; T Bartfai; et al.
Suppressed kindling epileptogenesis in mice with ectopic overexpression of galanin.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):14006-11.
2001: C Skogh; C Eriksson; M Kokaia; X C Meijer; L U Wahlberg; K Wictorin; K Campbell
Generation of regionally specified neurons in expanded glial cultures derived from the mouse and human lateral ganglionic eminence.
Molecular and cellular neurosciences 2001;17(5):811-20.
2001: I Ferencz; G Leanza; A Nanobashvili; Z Kokaia; M Kokaia; O Lindvall
Septal cholinergic neurons suppress seizure development in hippocampal kindling in rats: comparison with noradrenergic neurons.
Neuroscience 2001;102(4):819-32.
2000: A Nanobashvili; M S Airaksinen; M Kokaia; J Rossi; F Asztély; K Olofsdotter; P Mohapel; M Saarma; O Lindvall; Z Kokaia
Development and persistence of kindling epilepsy are impaired in mice lacking glial cell line-derived neurotrophic factor family receptor alpha 2.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):12312-7.
2000: I Ferencz; G Leanza; A Nanobashvili; M Kokaia; O Lindvall
Basal forebrain neurons suppress amygdala kindling via cortical but not hippocampal cholinergic projections in rats.
The European journal of neuroscience 2000;12(6):2107-16.
2000: F Asztely; M Kokaia; K Olofsdotter; U Ortegren; O Lindvall
Afferent-specific modulation of short-term synaptic plasticity by neurotrophins in dentate gyrus.
The European journal of neuroscience 2000;12(2):662-9.
2000: M Kokaia
Long-term potentiation of single subicular neurons in mice.
Hippocampus 2000;10(6):684-92.
1998: M Kokaia; F Asztely; K Olofsdotter; C B Sindreu; D M Kullmann; O Lindvall
Endogenous neurotrophin-3 regulates short-term plasticity at lateral perforant path-granule cell synapses.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(21):8730-9.
1998: M Y Min; F Asztely; M Kokaia; D M Kullmann
Long-term potentiation and dual-component quantal signaling in the dentate gyrus.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(8):4702-7.
1998: E Elmér; M Kokaia; Z Kokaia; D C McIntyre; O Lindvall
Epileptogenesis induced by rapidly recurring seizures in genetically fast- but not slow-kindling rats.
Brain research 1998;789(1):111-7.
1998: E Elmér; Z Kokaia; M Kokaia; J Carnahan; H Nawa; O Lindvall
Dynamic changes of brain-derived neurotrophic factor protein levels in the rat forebrain after single and recurring kindling-induced seizures.
Neuroscience 1998;83(2):351-62.
1998: I Ferencz; M Kokaia; E Elmér; M Keep; Z Kokaia; O Lindvall
Suppression of kindling epileptogenesis in rats by intrahippocampal cholinergic grafts.
The European journal of neuroscience 1998;10(1):213-20.
1997: J Bengzon; Z Kokaia; E Elmér; A Nanobashvili; M Kokaia; O Lindvall
Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(19):10432-7.
1997: I Ferencz; M Kokaia; M Keep; E Elmér; M Metsis; Z Kokaia; O Lindvall
Effects of cholinergic denervation on seizure development and neurotrophin messenger RNA regulation in rapid hippocampal kindling.
Neuroscience 1997;80(2):389-99.
1997: E Elmér; M Kokaia; P Ernfors; I Ferencz; Z Kokaia; O Lindvall
Suppressed kindling epileptogenesis and perturbed BDNF and TrkB gene regulation in NT-3 mutant mice.
Experimental neurology 1997;145(1):93-103.
1997: E Elmér; Z Kokaia; M Kokaia; O Lindvall; D C McIntyre
Mossy fibre sprouting: evidence against a facilitatory role in epileptogenesis.
Neuroreport 1997;8(5):1193-6.
1996: Z Kokaia; M E Kelly; E Elmer; M Kokaia; D C McIntyre; O Lindvall
Seizure-induced differential expression of messenger RNAs for neurotrophins and their receptors in genetically fast and slow kindling rats.
Neuroscience 1996;75(1):197-207.
1996: E Elmér; P Alm; Z Kokaia; M Kokaia; B Larsson; M Keep; K E Andersson; O Lindvall
Regulation of neuronal nitric oxide synthase mRNA levels in rat brain by seizure activity.
Neuroreport 1996;7(7):1335-9.
1996: Z Kokaia; H Nawa; H Uchino; E Elmér; M Kokaia; J Carnahan; M L Smith; B K Siesjö; O Lindvall
Regional brain-derived neurotrophic factor mRNA and protein levels following transient forebrain ischemia in the rat.
Brain research. Molecular brain research 1996;38(1):139-44.
1996: E Elmér; M Kokaia; Z Kokaia; I Ferencz; O Lindvall
Delayed kindling development after rapidly recurring seizures: relation to mossy fiber sprouting and neurotrophin, GAP-43 and dynorphin gene expression.
Brain research 1996;712(1):19-34.
1996: M Kokaia; I Ferencz; G Leanza; E Elmér; M Metsis; Z Kokaia; R G Wiley; O Lindvall
Immunolesioning of basal forebrain cholinergic neurons facilitates hippocampal kindling and perturbs neurotrophin messenger RNA regulation.
Neuroscience 1996;70(2):313-27.
1996: O Lindvall; Z Kokaia; J Bengzon; E Elmér; M Kokaia
Expression of neurotrophin mRNAs in the postischemic phase.
Advances in neurology 1996;71():405-11.
1995: Z Kokaia; Q Zhao; M Kokaia; E Elmér; M Metsis; M L Smith; B K Siesjö; O Lindvall
Regulation of brain-derived neurotrophic factor gene expression after transient middle cerebral artery occlusion with and without brain damage.
Experimental neurology 1995;136(1):73-88.
1995: M Kokaia; P Ernfors; Z Kokaia; E Elmér; R Jaenisch; O Lindvall
Suppressed epileptogenesis in BDNF mutant mice.
Experimental neurology 1995;133(2):215-24.
1995: Z Kokaia; M Metsis; M Kokaia; E Elmér; O Lindvall
Co-expression of TrkB and TrkC receptors in CNS neurones suggests regulation by multiple neurotrophins.
Neuroreport 1995;6(5):769-72.
1994: M Kokaia; M A Cenci; E Elmér; O G Nilsson; Z Kokaia; J Bengzon; A Björklund; O Lindvall
Seizure development and noradrenaline release in kindling epilepsy after noradrenergic reinnervation of the subcortically deafferented hippocampus by superior cervical ganglion or fetal locus coeruleus grafts.
Experimental neurology 1994;130(2):351-61.
1994: O Lindvall; Z Kokaia; J Bengzon; E Elmér; M Kokaia
Neurotrophins and brain insults.
Trends in neurosciences 1994;17(11):490-6.
1994: Z Kokaia; A Othberg; M Kokaia; O Lindvall
BDNF makes cultured dentate granule cells more resistant to hypoglycaemic damage.
Neuroreport 1994;5(10):1241-4.
1994: M Kokaia; G D Pratt; E Elmér; J Bengzon; J M Fritschy; Z Kokaia; O Lindvall; H Mohler
Biphasic differential changes of GABAA receptor subunit mRNA levels in dentate gyrus granule cells following recurrent kindling-induced seizures.
Brain research. Molecular brain research 1994;23(4):323-32.
1994: G D Pratt; M Kokaia
In situ hybridization and its application to receptor subunit mRNA regulation.
Trends in pharmacological sciences 1994;15(5):131-5.
1994: Z Kokaia; M Metsis; M Kokaia; J Bengzon; E Elmér; M L Smith; T Timmusk; B K Siesjö; H Persson; O Lindvall
Brain insults in rats induce increased expression of the BDNF gene through differential use of multiple promoters.
The European journal of neuroscience 1994;6(4):587-96.
1994: M Kokaia; P Aebischer; E Elmér; J Bengzon; P Kalén; Z Kokaia; O Lindvall
Seizure suppression in kindling epilepsy by intracerebral implants of GABA- but not by noradrenaline-releasing polymer matrices.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1994;100(3):385-94.
1993: G D Pratt; M Kokaia; J Bengzon; Z Kokaia; J M Fritschy; H Möhler; O Lindvall
Differential regulation of N-methyl-D-aspartate receptor subunit messenger RNAs in kindling-induced epileptogenesis.
Neuroscience 1993;57(2):307-18.
1993: Z Kokaia; G Gidö; T Ringstedt; J Bengzon; M Kokaia; B K Siesjö; H Persson; O Lindvall
Rapid increase of BDNF mRNA levels in cortical neurons following spreading depression: regulation by glutamatergic mechanisms independent of seizure activity.
Brain research. Molecular brain research 1993;19(4):277-86.
1993: Z Kokaia; J Bengzon; M Metsis; M Kokaia; H Persson; O Lindvall
Coexpression of neurotrophins and their receptors in neurons of the central nervous system.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(14):6711-5.
1993: J Bengzon; Z Kokaia; P Ernfors; M Kokaia; G Leanza; O G Nilsson; H Persson; O Lindvall
Regulation of neurotrophin and trkA, trkB and trkC tyrosine kinase receptor messenger RNA expression in kindling.
Neuroscience 1993;53(2):433-46.
1993: J P Merlio; P Ernfors; Z Kokaia; D S Middlemas; J Bengzon; M Kokaia; M L Smith; B K Siesjö; T Hunter; O Lindvall
Increased production of the TrkB protein tyrosine kinase receptor after brain insults.
Neuron 1993;10(2):151-64.
1992: J Bengzon; S Söderström; Z Kokaia; M Kokaia; P Ernfors; H Persson; T Ebendal; O Lindvall
Widespread increase of nerve growth factor protein in the rat forebrain after kindling-induced seizures.
Brain research 1992;587(2):338-42.
1991: J Bengzon; P Brundin; P Kalén; M Kokaia; O Lindvall
Host regulation of noradrenaline release from grafts of seizure-suppressant locus coeruleus neurons.
Experimental neurology 1991;111(1):49-54.
1990: J Bengzon; M Kokaia; P Brundin; O Lindvall
Seizure suppression in kindling epilepsy by intrahippocampal locus coeruleus grafts: evidence for an alpha-2-adrenoreceptor mediated mechanism.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1990;81(2):433-7.
1990: O Lindvall; J Bengzon; P Brundin; P Kalén; M Kokaia
Locus coeruleus grafts in hippocampal kindling epilepsy: noradrenaline release, receptor specificity and influence on seizure development.
Progress in brain research 1990;82():339-46.
1989: M Kokaia; J Bengzon; P Kalén; O Lindvall
Noradrenergic mechanisms in hippocampal kindling with rapidly recurring seizures.
Brain research 1989;491(2):398-402.
1989: M Kokaia; P Kalén; J Bengzon; O Lindvall
Noradrenaline and 5-hydroxytryptamine release in the hippocampus during seizures induced by hippocampal kindling stimulation: an in vivo microdialysis study.
Neuroscience 1989;32(3):647-56.
1988: P Kalén; M Kokaia; O Lindvall; A Björklund
Basic characteristics of noradrenaline release in the hippocampus of intact and 6-hydroxydopamine-lesioned rats as studied by in vivo microdialysis.
Brain research 1988;474(2):374-9.