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Gilbert Kokwaro

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M Ichagichu; S M Karanja; T Kariuki; Gilbert O Kokwaro; M Ngotho; Alexis Nzila; Hastings Ozwara
Preclinical drug evaluation system in the Plasmodium knowlesi baboon model of malaria: the methotrexate study.
Nahashon Thuo; Wanchana Ungphakorn; Japhet Karisa; Gilbert O Kokwaro; Simon N Muchohi; Alex Muturi; Alison H Thomson; Kathryn Maitland
Dosing regimens of oral ciprofloxacin for children with severe malnutrition: a population pharmacokinetic study with Monte Carlo simulation.
Simon N Muchohi; Nahashon Thuo; Japhet Karisa; Alex Muturi; Gilbert O Kokwaro; Kathryn Maitland
Determination of ciprofloxacin in human plasma using high-performance liquid chromatography coupled with fluorescence detection: application to a population pharmacokinetics study in children with severe malnutrition.

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All Publications

2013: M Ichagichu; S M Karanja; T Kariuki; Gilbert O Kokwaro; M Ngotho; Alexis Nzila; Hastings Ozwara
Preclinical drug evaluation system in the Plasmodium knowlesi baboon model of malaria: the methotrexate study.
Journal of medical primatology 2013;42(2):62-70.
2011: Nahashon Thuo; Wanchana Ungphakorn; Japhet Karisa; Gilbert O Kokwaro; Simon N Muchohi; Alex Muturi; Alison H Thomson; Kathryn Maitland
Dosing regimens of oral ciprofloxacin for children with severe malnutrition: a population pharmacokinetic study with Monte Carlo simulation.
The Journal of antimicrobial chemotherapy 2011;66(10):2336-45.
2011: Simon N Muchohi; Nahashon Thuo; Japhet Karisa; Alex Muturi; Gilbert O Kokwaro; Kathryn Maitland
Determination of ciprofloxacin in human plasma using high-performance liquid chromatography coupled with fluorescence detection: application to a population pharmacokinetics study in children with severe malnutrition.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2011;879(2):146-52.
2011: Evelyn N Gitau; Gilbert O Kokwaro; Charles Rjc Newton; Stephen A Ward
Global proteomic analysis of plasma from mice infected with Plasmodium berghei ANKA using two dimensional gel electrophoresis and matrix assisted laser desorption ionization-time of flight mass spectrometry.
Malaria journal 2011;10():205.
2011: Roma Chilengi; Rashid Juma; Ahmed M Abdallah; Mahfudh Bashraheil; Hudson Lodenyo; Priscilla Nyakundi; Evelyn Anabwani; Amina Salim; Gabriel Mwambingu; Ednah Wenwa; Julie Jemutai; Chemtai Kipkeu; George O Oyoo; Simon N Muchohi; Gilbert O Kokwaro; Tim Niehues; Trudie Lang; Alexis Nzila
A phase I trial to evaluate the safety and pharmacokinetics of low-dose methotrexate as an anti-malarial drug in Kenyan adult healthy volunteers.
Malaria journal 2011;10():63.
2010: Bertrand Lell; Carsten Köhler; Betty Wamola; Christopher Ho Olola; Esther Kivaya; Gilbert O Kokwaro; David Wypij; Sadik Mithwani; Terrie E Taylor; Song Le; Charles Newton
Pentoxifylline as an adjunct therapy in children with cerebral malaria.
Malaria journal 2010;9():368.
2009: Paul N Newton; Sue J Lee; Catherine Goodman; Facundo M Fernandez; Shunmay Yeung; Souly Phanouvong; Harparkash Kaur; Abdinasir A Amin; Christopher J M Whitty; Gilbert O Kokwaro; Niklas Lindegårdh; Patrick Lukulay; Lisa J White; Nicholas P J Day; Michael D Green; Nicholas J White
Guidelines for field surveys of the quality of medicines: a proposal.
PLoS medicine 2009;6(3):e52.
2008: Simon N Muchohi; Gilbert O Kokwaro; Bernhards R Ogutu; Geoffrey Edwards; Steve A Ward; Charles Newton
Pharmacokinetics and clinical efficacy of midazolam in children with severe malaria and convulsions.
British journal of clinical pharmacology 2008;66(4):529-38.
2008: Eunice Nduati; Abdi Diriye; Sheila Ommeh; Leah Mwai; Steven Kiara; Victor Masseno; Gilbert O Kokwaro; Alexis Nzila
Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancer.
Parasitology research 2008;102(6):1227-34.
2008: Simon N Muchohi; Kenneth Obiero; Charles Newton; Bernhards R Ogutu; Geoffrey Edwards; Gilbert O Kokwaro
Pharmacokinetics and clinical efficacy of lorazepam in children with severe malaria and convulsions.
British journal of clinical pharmacology 2008;65(1):12-21.
2007: Abdinasir A Amin; Gilbert O Kokwaro
Antimalarial drug quality in Africa.
Journal of clinical pharmacy and therapeutics 2007;32(5):429-40.
2007: Claire Seaton; James Ignas; Simon N Muchohi; Gilbert O Kokwaro; Kathryn Maitland; Alison H Thomson
Population pharmacokinetics of a single daily intramuscular dose of gentamicin in children with severe malnutrition.
The Journal of antimicrobial chemotherapy 2007;59(4):681-9.
2007: Abdinasir A Amin; Tom Walley; Gilbert O Kokwaro; Peter A Winstanley; Robert W Snow
Reconciling national treatment policies and drug regulation in Kenya.
Health policy and planning 2007;22(2):111-2.
2007: Gilbert O Kokwaro; Leah Mwai; Alexis Nzila
Artemether/lumefantrine in the treatment of uncomplicated falciparum malaria.
Expert opinion on pharmacotherapy 2007;8(1):75-94.
2006: Gilbert O Kokwaro; Simon N Muchohi; Bernhards R Ogutu; Charles Newton
Chloramphenicol pharmacokinetics in African children with severe malaria.
Journal of tropical pediatrics 2006;52(4):239-43.
2006: Phillip Sasi; Mike English; James A Berkley; Brett Lowe; M Shebe; R Mwakesi; Gilbert O Kokwaro
Characterisation of metabolic acidosis in Kenyan children admitted to hospital for acute non-surgical conditions.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2006;100(5):401-9.
2005: Abdinasir A Amin; Robert W Snow; Gilbert O Kokwaro
The quality of sulphadoxine-pyrimethamine and amodiaquine products in the Kenyan retail sector.
Journal of clinical pharmacy and therapeutics 2005;30(6):559-65.
2005: Simon N Muchohi; Kenneth Obiero; Gilbert O Kokwaro; Bernhards R Ogutu; Isaiah M Githiga; Geoffrey Edwards; Charles Newton
Determination of lorazepam in plasma from children by high-performance liquid chromatography with UV detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;824(1-2):333-40.
2005: Gilbert O Kokwaro
Once-daily combination therapy for uncomplicated malaria: is this the way forward?
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005;41(4):433-4.
2005: Bernhards R Ogutu; Gilbert O Kokwaro
Combination therapy in the treatment of malaria.
East African medical journal 2005;82(8):385-6.
2005: Simon N Muchohi; Steve A Ward; Louise Preston; Charles Newton; Geoffrey Edwards; Gilbert O Kokwaro
Determination of midazolam and its major metabolite 1'-hydroxymidazolam by high-performance liquid chromatography-electrospray mass spectrometry in plasma from children.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;821(1):1-7.
2005: Bernhards R Ogutu; Alexis Nzila; E Ochong; Sadik Mithwani; B Wamola; Dr Chris Olola; B Lowe; Gilbert O Kokwaro; Kevin Marsh; Charles Newton
The role of sequential administration of sulphadoxine/pyrimethamine following quinine in the treatment of severe falciparum malaria in children.
Tropical medicine & international health : TM & IH 2005;10(5):484-8.
2004: Sheila Ommeh; Eunice Nduati; Edward K Mberu; Gilbert O Kokwaro; Kevin Marsh; Andre Rosowsky; Alexis Nzila
In vitro activities of 2,4-diaminoquinazoline and 2,4-diaminopteridine derivatives against Plasmodium falciparum.
Antimicrobial agents and chemotherapy 2004;48(10):3711-4.
2004: Abdinasir A Amin; Dyfrig A Hughes; Vicki Marsh; Timothy O Abuya; Gilbert O Kokwaro; Peter A Winstanley; Sam A Ochola; Robert W Snow
The difference between effectiveness and efficacy of antimalarial drugs in Kenya.
Tropical medicine & international health : TM & IH 2004;9(9):967-74.
2004: Mike English; S Mohammed; A Ross; S Ndirangu; Gilbert O Kokwaro; F Shann; Kevin Marsh
A randomised, controlled trial of once daily and multi-dose daily gentamicin in young Kenyan infants.
Archives of disease in childhood 2004;89(7):665-9.
2004: Isaiah M Githiga; Simon N Muchohi; Bernhards R Ogutu; Charles Newton; Godfrey O Otieno; Evelyn N Gitau; Gilbert O Kokwaro
Determination of paraldehyde by gas chromatography in whole blood from children.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;805(2):365-9.
2004: Bill Watkins; Gilbert O Kokwaro; Mary R Galinski; Theonest K Mutabingwa; Jean-François Trape
WHO, the Global Fund, and medical malpractice in malaria treatment.
Lancet 2004;363(9415):1161-2.
2004: Alexis Nzila; Gilbert O Kokwaro; Peter A Winstanley; Kevin Marsh; Stephen A Ward
Therapeutic potential of folate uptake inhibition in Plasmodium falciparum.
Trends in parasitology 2004;20(3):109-12.
2004: Sadik Mithwani; Leon Aarons; Gilbert O Kokwaro; Oneeb Majid; Simon N Muchohi; Geoffrey Edwards; Sumia Mohamed; Kevin Marsh; William Watkins
Population pharmacokinetics of artemether and dihydroartemisinin following single intramuscular dosing of artemether in African children with severe falciparum malaria.
British journal of clinical pharmacology 2004;57(2):146-52.
2004: Amir Attaran; Karen I Barnes; Christopher Curtis; Umberto D'Alessandro; Caterina Fanello; Mary R Galinski; Gilbert O Kokwaro; Sornchai Looareesuwan; Michael Makanga; Theonest K Mutabingwa; Ambrose O Talisuna; Jean-François Trape; William M Watkins
WHO, the Global Fund, and medical malpractice in malaria treatment.
Lancet 2004;363(9404):237-40.
2004: E N Gitau; Simon N Muchohi; Bernhards R Ogutu; Isaiah M Githiga; Gilbert O Kokwaro
Selective and sensitive liquid chromatographic assay of amodiaquine and desethylamodiaquine in whole blood spotted on filter paper.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;799(1):173-7.
2003: Gilbert O Kokwaro; Bernhards R Ogutu; Simon N Muchohi; Godfrey O Otieno; Charles Newton
Pharmacokinetics and clinical effect of phenobarbital in children with severe falciparum malaria and convulsions.
British journal of clinical pharmacology 2003;56(4):453-7.
2003: Bernhards R Ogutu; Charles Newton; Simon N Muchohi; Godfrey O Otieno; Geoffrey Edwards; William M Watkins; Gilbert O Kokwaro
Pharmacokinetics and clinical effects of phenytoin and fosphenytoin in children with severe malaria and status epilepticus.
British journal of clinical pharmacology 2003;56(1):112-9.
2003: Alison H Thomson; Gilbert O Kokwaro; Simon N Muchohi; Michael English; Shebbe Mohammed; Geoffrey Edwards
Population pharmacokinetics of intramuscular gentamicin administered to young infants with suspected severe sepsis in Kenya.
British journal of clinical pharmacology 2003;56(1):25-31.
2003: Alexis Nzila; Edward K Mberu; Pat Bray; Gilbert O Kokwaro; Peter A Winstanley; Kevin Marsh; Steve Ward
Chemosensitization of Plasmodium falciparum by probenecid in vitro.
Antimicrobial agents and chemotherapy 2003;47(7):2108-12.
2002: Joe O Oundo; F Muli; SAMUEL KARIUKI; Peter Waiyaki; Y Iijima; James A Berkley; Gilbert O Kokwaro; Caroline Ngetsa; Salim Mwarumba; R Torto; Brett Lowe
Non-typhi salmonella in children with severe malaria.
East African medical journal 2002;79(12):633-9.
2002: Bernhards R Ogutu; Charles Newton; Simon N Muchohi; Godfrey O Otieno; Gilbert O Kokwaro
Phenytoin pharmacokinetics and clinical effects in African children following fosphenytoin and chloramphenicol coadministration.
British journal of clinical pharmacology 2002;54(6):635-42.
2002: Edward K Mberu; Alexis Nzila; Eunice Nduati; Amanda Ross; Stephanie M Monks; Gilbert O Kokwaro; William M Watkins; Carol Hopkins Sibley
Plasmodium falciparum: in vitro activity of sulfadoxine and dapsone in field isolates from Kenya: point mutations in dihydropteroate synthase may not be the only determinants in sulfa resistance.
Experimental parasitology 2002;101(2-3):90-6.
2002: Simon N Muchohi; Gilbert O Kokwaro; T E Maitho; R W Munenge; William M Watkins; Geoffrey Edwards
Pharmacokinetics of phenytoin following intravenous and intramuscular administration of fosphenytoin and phenytoin sodium in the rabbit.
European journal of drug metabolism and pharmacokinetics 2002;27(2):83-9.
2002: Bernhards R Ogutu; Charles Newton; J Crawley; Simon N Muchohi; Godfrey O Otieno; Geoffrey Edwards; Kevin Marsh; Gilbert O Kokwaro
Pharmacokinetics and anticonvulsant effects of diazepam in children with severe falciparum malaria and convulsions.
British journal of clinical pharmacology 2002;53(1):49-57.
2000: Jane Crawley; Gilbert O Kokwaro; D Ouma; William Watkins; Kevin Marsh
Chloroquine is not a risk factor for seizures in childhood cerebral malaria.
Tropical medicine & international health : TM & IH 2000;5(12):860-4.
2000: Edward K Mberu; Moses Mosobo; Alexis Nzila; Gilbert O Kokwaro; Carol Hopkins Sibley; William M Watkins
The changing in vitro susceptibility pattern to pyrimethamine/sulfadoxine in Plasmodium falciparum field isolates from Kilifi, Kenya.
The American journal of tropical medicine and hygiene 2000;62(3):396-401.
1999: Nicholas J White; François Nosten; Sornchai Looareesuwan; William M Watkins; K Marsh; R W Snow; Gilbert O Kokwaro; J Ouma; Tran Tinh Hien; M E Molyneux; Terrie E Taylor; C I Newbold; Trenton K Ruebush; M Danis; B M Greenwood; R M Anderson; Piero Olliaro
Averting a malaria disaster.
Lancet 1999;353(9168):1965-7.
1998: Gilbert O Kokwaro
Use of Artemisinin (Qinghaosu) derivatives in the treatment of malaria.
African journal of health sciences 1998;5(1):8-11.
1998: Gilbert O Kokwaro
Medical Research: Are we doing enough in Africa?
African journal of health sciences 1998;5(1):1.
1997: Gilbert O Kokwaro; G Edwards; P Roberts; S Ward; Peter A Winstanley; William Watkins
Infection with Plasmodium berghei alters benzodiazepine receptor in rat brain.
Archives of medical research 1997;28(3):425-7.
1996: Gilbert O Kokwaro; T O Kwasa; A A Indalo; I O Kibwage
Steady-state anticonvulsant drug levels in epileptic patients.
East African medical journal 1996;73(10):679-82.
1996: Gilbert O Kokwaro; A A Indalo
Oxamniquine inhibits metabolism of caffeine, hexobarbitone and antipyrine in vivo in mice.
African journal of health sciences 1996;3(3):105-8.
1996: Gilbert O Kokwaro; A A Indalo
Effect of route of administration on systematic availability of oxamniquine in the rabbit.
African journal of health sciences 1996;3(3):101-4.
1996: M O Oluka; ES Mitema; I O Kibwage; T O Kwasa; Gilbert O Kokwaro
A comparative bioavailability of four Carbamazepine tablet formulations available in the Kenyan market.
East African medical journal 1996;73(5):323-6.
1996: Gilbert O Kokwaro; A A Indalo
Metabolism of Diazepam and Ethosuximide in rats with malaria and endotoxin-induced fever.
African journal of health sciences 1996;3(1):22-6.
1996: Gilbert O Kokwaro; A A Indalo; G Taylor
Pharmacokinetics of oxamniquine in rabbit and rat.
European journal of drug metabolism and pharmacokinetics 1996;21(1):13-6.
1995: Gilbert O Kokwaro
Pharmacokinetic basis of nifedipine-digoxin interaction: a commentary.
East African medical journal 1995;72(10):684-7.
1995: A A Indalo; Gilbert O Kokwaro
Pharmacokinetics of temazepam in male surgical patients.
East African medical journal 1995;72(8):483-5.
1991: Gilbert O Kokwaro; G Taylor
Oxamniquine pharmacokinetics in healthy Kenyan African volunteers.
East African medical journal 1991;68(5):359-64.