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Padmini Komalavilas

Research Profile

Chemicals & Drugs

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Phosphorylation

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Publications

TOP 3
Fan Dong Li; Michael J Osgood; Kevin W Sexton; Colleen M Brophy; Joyce Cheung-Flynn; Susan Eagle; Kyle M Hocking; Padmini Komalavilas
Intimal thickness associated with endothelial dysfunction in human vein grafts.
Michael J Osgood; Charles R Flynn; Padmini Komalavilas; Colleen M Brophy
Cell-permeant peptide inhibitors of vasospasm and intimal hyperplasia.
Kyle M Hocking; Franz J Baudenbacher; Colleen M Brophy; Joyce Cheung-Flynn; Gowthami Putumbaka; Sneha Venkatraman; Padmini Komalavilas
Role of cyclic nucleotide-dependent actin cytoskeletal dynamics: [ca(2+)]I and force suppression in forskolin-pretreated porcine coronary arteries.

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All Publications

2013: Fan Dong Li; Michael J Osgood; Kevin W Sexton; Colleen M Brophy; Joyce Cheung-Flynn; Susan Eagle; Kyle M Hocking; Padmini Komalavilas
Intimal thickness associated with endothelial dysfunction in human vein grafts.
The Journal of surgical research 2013;180(1):e55-62.
2013: Michael J Osgood; Charles R Flynn; Padmini Komalavilas; Colleen M Brophy
Cell-permeant peptide inhibitors of vasospasm and intimal hyperplasia.
Vascular 2013;21(1):46-53.
2013: Kyle M Hocking; Franz J Baudenbacher; Colleen M Brophy; Joyce Cheung-Flynn; Gowthami Putumbaka; Sneha Venkatraman; Padmini Komalavilas
Role of cyclic nucleotide-dependent actin cytoskeletal dynamics: [ca(2+)]I and force suppression in forskolin-pretreated porcine coronary arteries.
PloS one 2013;8(4):e60986.
2012: Michael J Osgood; Kevin W Sexton; Igor V Voskresensky; Joyce Cheung-Flynn; Raul J Guzman; David G Harrison; Kyle M Hocking; Padmini Komalavilas; Colleen M Brophy
Role of the renin-angiotensin system in the pathogenesis of intimal hyperplasia: therapeutic potential for prevention of vein graft failure?
Annals of vascular surgery 2012;26(8):1130-44.
2012: Akihito Muto; Alyssa Panitch; Kinam Park; Colleen M Brophy; Namho Kim; Padmini Komalavilas; Alan Dardik
Inhibition of Mitogen Activated Protein Kinase Activated Protein Kinase II with MMI-0100 reduces intimal hyperplasia ex vivo and in vivo.
Vascular pharmacology 2012;56(1-2):47-55.
2011: Susan Eagle; Kyle Hocking; Padmini Komalavilas; Marzia Leacche; Michael Osgood; Gowthami Putumbaka; Kevin Sexton; Colleen M Brophy; Joyce Cheung-Flynn
Surgical skin markers impair human saphenous vein graft smooth muscle and endothelial function.
The American surgeon 2011;77(7):922-8.
2011: Kyle M Hocking; Colleen M Brophy; Syed Z Rizvi; Padmini Komalavilas; Susan Eagle; Marzia Leacche; Jorge M Balaguer; Joyce Cheung-Flynn
Detrimental effects of mechanical stretch on smooth muscle function in saphenous veins.
Journal of vascular surgery 2011;53(2):454-60.
2010: Luciana B Lopes; Colleen M Brophy; Charles R Flynn; Zhengping Yi; Benjamin P Bowen; Christopher Smoke; Brandon Seal; Alyssa Panitch; Padmini Komalavilas
A novel cell permeant peptide inhibitor of MAPKAP kinase II inhibits intimal hyperplasia in a human saphenous vein organ culture model.
Journal of vascular surgery 2010;52(6):1596-607.
2010: Catherine M Dreiza; Padmini Komalavilas; Elizabeth J Furnish; Charles R Flynn; Michael R Sheller; Christopher C Smoke; Luciana B Lopes; Colleen M Brophy
The small heat shock protein, HSPB6, in muscle function and disease.
Cell stress & chaperones 2010;15(1):1-11.
2009: Luciana B Lopes; Charles Flynn; Padmini Komalavilas; Alyssa Panitch; Colleen M Brophy; Brandon L Seal
Inhibition of HSP27 phosphorylation by a cell-permeant MAPKAP Kinase 2 inhibitor.
Biochemical and biophysical research communications 2009;382(3):535-9.
2009: Luciana B Lopes; Elizabeth J Furnish; Padmini Komalavilas; Charles R Flynn; Patricia Ashby; Adam Hansen; Daphne P Ly; George P Yang; Michael T Longaker; Alyssa Panitch; Colleen M Brophy
Cell permeant peptide analogues of the small heat shock protein, HSP20, reduce TGF-beta1-induced CTGF expression in keloid fibroblasts.
The Journal of investigative dermatology 2009;129(3):590-8.
2008: Luciana B Lopes; Elizabeth J Furnish; Padmini Komalavilas; Brandon L Seal; Alyssa Panitch; M Vitória L B Bentley; Colleen M Brophy
Enhanced skin penetration of P20 phosphopeptide using protein transduction domains.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;68(2):441-5.
2008: Padmini Komalavilas; Raymond B Penn; Charles R Flynn; Jeffrey S Thresher; Luciana B Lopes; Elizabeth J Furnish; Manhong Guo; Manuel Antonio Pallero; Joanne E Murphy-Ullrich; Colleen M Brophy
The small heat shock-related protein, HSP20, is a cAMP-dependent protein kinase substrate that is involved in airway smooth muscle relaxation.
American journal of physiology. Lung cellular and molecular physiology 2008;294(1):L69-78.
2007: Charles R Flynn; Christopher C Smoke; Elizabeth J Furnish; Padmini Komalavilas; Jeffrey S Thresher; Zhengping Yi; Lawrence J. Manderino; Colleen M Brophy
Phosphorylation and activation of a transducible recombinant form of human HSP20 in Escherichia coli.
Protein expression and purification 2007;52(1):50-8.
2005: Elisabeth C McLemore; Deron J Tessier; Jeffrey S Thresher; Padmini Komalavilas; Colleen M Brophy
Role of the small heat shock proteins in regulating vascular smooth muscle tone.
Journal of the American College of Surgeons 2005;201(1):30-6.
2005: Luciana B Lopes; Colleen M Brophy; Elizabeth J Furnish; Charles R Flynn; Olivia Sparks; Padmini Komalavilas; Lokesh Joshi; Alyssa Panitch; M Vitória L B Bentley
Comparative study of the skin penetration of protein transduction domains and a conjugated peptide.
Pharmaceutical research 2005;22(5):750-7.
2005: Charles R Flynn; Colleen M Brophy; Elizabeth J Furnish; Padmini Komalavilas; Deron J Tessier; Jeffrey S Thresher; Lokesh Joshi
Transduction of phosphorylated heat shock-related protein 20, HSP20, prevents vasospasm of human umbilical artery smooth muscle.
Journal of applied physiology (Bethesda, Md. : 1985) 2005;98(5):1836-45.
2005: Catherine M Dreiza; Colleen M Brophy; Padmini Komalavilas; Elizabeth J Furnish; Lokesh Joshi; Manuel Antonio Pallero; Joanne E Murphy-Ullrich; Moritz von Rechenberg; Yew-Seng J Ho; Bonnie Richardson; Nafei Xu; Yuejun Zhen; John M Peltier; Alyssa Panitch
Transducible heat shock protein 20 (HSP20) phosphopeptide alters cytoskeletal dynamics.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(2):261-3.
2004: Elisabeth C McLemore; Deron J Tessier; Charles R Flynn; Elizabeth J Furnish; Padmini Komalavilas; Jeffrey S Thresher; Lokesh Joshi; William M Stone; Richard J Fowl; Colleen M Brophy
Transducible recombinant small heat shock-related protein, HSP20, inhibits vasospasm and platelet aggregation.
Surgery 2004;136(3):573-8.
2004: Deron J Tessier; Padmini Komalavilas; Bo Liu; Craig K Kent; Jeffrey S Thresher; Catherine M Dreiza; Alyssa Panitch; Lokesh Joshi; Elizabeth J Furnish; William Stone; Richard J Fowl; Colleen M Brophy
Transduction of peptide analogs of the small heat shock-related protein HSP20 inhibits intimal hyperplasia.
Journal of vascular surgery 2004;40(1):106-14.
2004: Colleen M Brophy; Padmini Komalavilas
Heat shock-related protein 20 (HSP20) in cardiomyocytes.
Circulation research 2004;94(10):e85.
2004: Deron J Tessier; Padmini Komalavilas; Elisabeth C McLemore; Jeffrey S Thresher; Colleen M Brophy
Sildenafil-induced vasorelaxation is associated with increases in the phosphorylation of the heat shock-related protein 20 (HSP20).
The Journal of surgical research 2004;118(1):21-5.
2003: Charles R Flynn; Padmini Komalavilas; Deron J Tessier; Jeffrey S Thresher; Eric E Niederkofler; Catherine M Dreiza; Randall W Nelson; Alyssa Panitch; Lokesh Joshi; Colleen M Brophy
Transduction of biologically active motifs of the small heat shock-related protein HSP20 leads to relaxation of vascular smooth muscle.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(10):1358-60.
2003: Deron J Tessier; Padmini Komalavilas; Alyssa Panitch; Lokesh Joshi; Colleen M Brophy
The small heat shock protein (HSP) 20 is dynamically associated with the actin cross-linking protein actinin.
The Journal of surgical research 2003;111(1):152-7.
2003: David Woodrum; Walter L Pipkin; Deron J Tessier; Padmini Komalavilas; Colleen M Brophy
Phosphorylation of the heat shock-related protein, HSP20, mediates cyclic nucleotide-dependent relaxation.
Journal of vascular surgery 2003;37(4):874-81.
2003: Walter L Pipkin; John A Johnson; Tony L Creazzo; Jarrett Burch; Padmini Komalavilas; Colleen M Brophy
Localization, macromolecular associations, and function of the small heat shock-related protein HSP20 in rat heart.
Circulation 2003;107(3):469-76.
2002: Colleen M Brophy; David Woodrum; Jennifer Pollock; Mary Dickinson; Padmini Komalavilas; Trudy L Cornwell; Thomas M Lincoln
cGMP-dependent protein kinase expression restores contractile function in cultured vascular smooth muscle cells.
Journal of vascular research 2002;39(2):95-103.
2001: Padmini Komalavilas; Shyamal Haresh Mehta; Christopher J Wingard; DT Dransfield; J Bhalla; JE Woodrum; J R Molinaro; Colleen M Brophy
PI3-kinase/Akt modulates vascular smooth muscle tone via cAMP signaling pathways.
Journal of applied physiology (Bethesda, Md. : 1985) 2001;91(4):1819-27.
1999: Rajiv Kumar; Ronald W Joyner; Padmini Komalavilas; Thomas M Lincoln
Analysis of expression of cGMP-dependent protein kinase in rabbit heart cells.
The Journal of pharmacology and experimental therapeutics 1999;291(3):967-75.
1999: Padmini Komalavilas; P K Shah; Hanjoong Jo; Thomas M Lincoln
Activation of mitogen-activated protein kinase pathways by cyclic GMP and cyclic GMP-dependent protein kinase in contractile vascular smooth muscle cells.
The Journal of biological chemistry 1999;274(48):34301-9.
1998: Robert M Weisbrod; MC Griswold; M Yaghoubi; Padmini Komalavilas; Thomas M Lincoln; Richard A Cohen
Evidence that additional mechanisms to cyclic GMP mediate the decrease in intracellular calcium and relaxation of rabbit aortic smooth muscle to nitric oxide.
British journal of pharmacology 1998;125(8):1695-707.
1998: Brian W Fouty; Padmini Komalavilas; M Muramatsu; ALAN COHEN; Ivan F McMurtry; Thomas M Lincoln; David M Rodman
Protein kinase G is not essential to NO-cGMP modulation of basal tone in rat pulmonary circulation.
The American journal of physiology 1998;274(2 Pt 2):H672-8.
1996: Padmini Komalavilas; Thomas M Lincoln
Phosphorylation of the inositol 1,4,5-trisphosphate receptor. Cyclic GMP-dependent protein kinase mediates cAMP and cGMP dependent phosphorylation in the intact rat aorta.
The Journal of biological chemistry 1996;271(36):21933-8.
1996: Thomas M Lincoln; Trudy L Cornwell; Padmini Komalavilas; NJ Boerth
Cyclic GMP-dependent protein kinase in nitric oxide signaling.
Methods in enzymology 1996;269():149-66.
1995: Thomas M Lincoln; Padmini Komalavilas; NJ Boerth; Lee Ann MacMillan-Crow; Trudy L Cornwell
cGMP signaling through cAMP- and cGMP-dependent protein kinases.
Advances in pharmacology (San Diego, Calif.) 1995;34():305-22.
1994: Thomas M Lincoln; Padmini Komalavilas; Trudy L Cornwell
Pleiotropic regulation of vascular smooth muscle tone by cyclic GMP-dependent protein kinase.
Hypertension 1994;23(6 Pt 2):1141-7.
1994: Padmini Komalavilas; Thomas M Lincoln
Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase.
The Journal of biological chemistry 1994;269(12):8701-7.