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Toshimitsu Komatsu

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Takahiro Hayashida; Yasuko Henmi; Ae Ra Kim; Toshimitsu Komatsu; Takuya Chiba; Hae Young Chung; Shinji Goto; Kurumi Yanagihara-Ota; Isao Shimokawa
Modest inhibition of the growth hormone axis does not affect mitochondrial reactive oxygen species generation or redox state, unlike calorie restriction.
Toshimitsu Komatsu; Lucas S Trindade; Takuya Chiba; Hiroko Hayashi; Tomoko Henmi; Yoko Ushiroda; Ryoichi Mori; Isao Shimokawa
Acute stress response modified by modest inhibition of growth hormone axis: a potential machinery of the anti-aging effect of calorie restriction.
Takuya Chiba; Tomoshi Tsuchiya; Toshimitsu Komatsu; Ryoichi Mori; Hiroko Hayashi; Isao Shimokawa
Development of calorie restriction mimetics as therapeutics for obesity, diabetes, inflammatory and neurodegenerative diseases.

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2011: Takahiro Hayashida; Yasuko Henmi; Ae Ra Kim; Toshimitsu Komatsu; Takuya Chiba; Hae Young Chung; Shinji Goto; Kurumi Yanagihara-Ota; Isao Shimokawa
Modest inhibition of the growth hormone axis does not affect mitochondrial reactive oxygen species generation or redox state, unlike calorie restriction.
Geriatrics & gerontology international 2011;11(4):496-503.
2011: Toshimitsu Komatsu; Lucas S Trindade; Takuya Chiba; Hiroko Hayashi; Tomoko Henmi; Yoko Ushiroda; Ryoichi Mori; Isao Shimokawa
Acute stress response modified by modest inhibition of growth hormone axis: a potential machinery of the anti-aging effect of calorie restriction.
Mechanisms of ageing and development 2011;132(3):103-9.
2010: Takuya Chiba; Tomoshi Tsuchiya; Toshimitsu Komatsu; Ryoichi Mori; Hiroko Hayashi; Isao Shimokawa
Development of calorie restriction mimetics as therapeutics for obesity, diabetes, inflammatory and neurodegenerative diseases.
Current genomics 2010;11(8):562-7.
2010: Takuya Chiba; Tomoshi Tsuchiya; Toshimitsu Komatsu; Ryoichi Mori; Hiroko Hayashi; Hitoshi Shimano; Stephen R Spindler; Isao Shimokawa
Development of a bioassay to screen for chemicals mimicking the anti-aging effects of calorie restriction.
Biochemical and biophysical research communications 2010;401(2):213-8.
2010: Haruyoshi Yamaza; Toshimitsu Komatsu; Saori Wakita; Carole Kijogi; Seongjoon Park; Hiroko Hayashi; Takuya Chiba; Ryoichi Mori; Tatsuo Furuyama; Nozomu Mori; Isao Shimokawa
FoxO1 is involved in the antineoplastic effect of calorie restriction.
Aging cell 2010;9(3):372-82.
2009: Takuya Chiba; Toshimitsu Komatsu; Masahiko Nakayama; Toshiyuki Adachi; Yukari Tamashiro; Hiroko Hayashi; Haruyoshi Yamaza; Yoshikazu Higami; Isao Shimokawa
Similar metabolic responses to calorie restriction in lean and obese Zucker rats.
Molecular and cellular endocrinology 2009;309(1-2):17-25.
2009: Seongjoon Park; Toshimitsu Komatsu; Hiroko Hayashi; Lucas Siqueira Trindade; Haruyoshi Yamaza; Takuya Chiba; Isao Shimokawa
Divergent regulation of adipose tissue metabolism by calorie restriction and inhibition of growth hormone signaling.
Experimental gerontology 2009;44(10):646-52.
2009: Takuya Chiba; Daisuke Inoue; Aya Mizuno; Toshimitsu Komatsu; Satoshi Fujita; Haruaki Kubota; Maria Luisa Tagliaro; Seongjoon Park; Lucas Siqueira Trindade; Takahiro Hayashida; Hiroko Hayashi; Haruyoshi Yamaza; Yoshikazu Higami; Isao Shimokawa
Identification and characterization of an insulin receptor substrate 4-interacting protein in rat brain: implications for longevity.
Neurobiology of aging 2009;30(3):474-82.
2008: Seongjoon Park; Toshimitsu Komatsu; Hiroko Hayashi; Haruyoshi Yamaza; Takuya Chiba; Yoshikazu Higami; Kazunao Kuramoto; Isao Shimokawa
Calorie restriction initiated at a young age activates the Akt/PKC zeta/lambda-Glut4 pathway in rat white adipose tissue in an insulin-independent manner.
Age (Dordrecht, Netherlands) 2008;30(4):293-302.
2008: Isao Shimokawa; Takuya Chiba; Haruyoshi Yamaza; Toshimitsu Komatsu
Longevity genes: insights from calorie restriction and genetic longevity models.
Molecules and cells 2008;26(5):427-35.
2008: Hiroko Hayashi; Haruyoshi Yamaza; Toshimitsu Komatsu; Seongjoon Park; Takuya Chiba; Yoshikazu Higami; Takeshi Nagayasu; Isao Shimokawa
Calorie restriction minimizes activation of insulin signaling in response to glucose: potential involvement of the growth hormone-insulin-like growth factor 1 axis.
Experimental gerontology 2008;43(9):827-32.
2008: Takuya Chiba; Haruyoshi Yamaza; Toshimitsu Komatsu; Masahiko Nakayama; Satoshi Fujita; Hiroko Hayashi; Yoshikazu Higami; Isao Shimokawa
Pituitary growth hormone suppression reduces resistin expression and enhances insulin effectiveness: relationship with caloric restriction.
Experimental gerontology 2008;43(6):595-600.
2008: Toshimitsu Komatsu; Takuya Chiba; Haruyoshi Yamaza; Kimihiro Yamashita; Atsuyoshi Shimada; Yasuyo Hoshiyama; Tomoko Henmi; Hiroshi Ohtani; Yoshikazu Higami; Rafael de Cabo; Donald Ingram; Isao Shimokawa
Manipulation of caloric content but not diet composition, attenuates the deficit in learning and memory of senescence-accelerated mouse strain P8.
Experimental gerontology 2008;43(4):339-46.
2007: Kazuo To; Haruyoshi Yamaza; Toshimitsu Komatsu; Takahiro Hayashida; Hiroko Hayashi; Hiroaki Toyama; Takuya Chiba; Yoshikazu Higami; Isao Shimokawa
Down-regulation of AMP-activated protein kinase by calorie restriction in rat liver.
Experimental gerontology 2007;42(11):1063-71.
2007: Haruyoshi Yamaza; Toshimitsu Komatsu; Kazuo To; Hiroaki Toyama; Takuya Chiba; Yoshikazu Higami; Isao Shimokawa
Involvement of insulin-like growth factor-1 in the effect of caloric restriction: regulation of plasma adiponectin and leptin.
The journals of gerontology. Series A, Biological sciences and medical sciences 2007;62(1):27-33.
2006: Toshimitsu Komatsu; Takuya Chiba; Haruyoshi Yamaza; Kazuo To; Hiroaki Toyama; Yoshikazu Higami; Isao Shimokawa
Effect of leptin on hypothalamic gene expression in calorie-restricted rats.
The journals of gerontology. Series A, Biological sciences and medical sciences 2006;61(9):890-8.
2005: Tomoshi Tsuchiya; Yoshikazu Higami; Toshimitsu Komatsu; Kenji Tanaka; Sumihisa Honda; Haruyoshi Yamaza; Takuya Chiba; Hiroyoshi Ayabe; Isao Shimokawa
Acute stress response in calorie-restricted rats to lipopolysaccharide-induced inflammation.
Mechanisms of ageing and development 2005;126(5):568-79.
2004: Haruyoshi Yamaza; Toshimitsu Komatsu; Takuya Chiba; Hiroaki Toyama; Kazuo To; Yoshikazu Higami; Isao Shimokawa
A transgenic dwarf rat model as a tool for the study of calorie restriction and aging.
Experimental gerontology 2004;39(2):269-72.
2003: Isao Shimokawa; Yoshikazu Higami; Tomoshi Tsuchiya; Hiroshi Otani; Toshimitsu Komatsu; Takuya Chiba; Haruyoshi Yamaza
Life span extension by reduction of the growth hormone-insulin-like growth factor-1 axis: relation to caloric restriction.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(9):1108-9.