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Hitoshi Komatsuzawa

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Kenji Kukita; Mami Nagatomo; Takahiko Oho; Yuichi Oogai; Yasuo Suda; Takuo Tanaka; Masahito Hashimoto; Miki Kawada-Matsuo; Hitoshi Komatsuzawa
Staphylococcus aureus SasA Is Responsible for Binding to the Salivary Agglutinin gp340, Derived from Human Saliva.
Naohiro Shimotahira; Sakuo Yamada; Fuminobu Yoshimura; Kenji Fukutsuji; Miki Kawada-Matsuo; Keiji Nagano; Kazuyuki Noguchi; Yuichi Oogai; Hitoshi Komatsuzawa
The surface layer of Tannerella forsythia contributes to serum resistance and oral bacterial coaggregation.
M Kittaka; Hitoshi Komatsuzawa; Kazuhisa Ouhara; Hideki Shiba; Katsuhiro Takeda; Tsuyoshi Fujita; M Kajiya; K Kanbara; Hiroyuki Kawaguchi; Hidemi Kurihara
Antimicrobial peptide LL37 promotes vascular endothelial growth factor-A expression in human periodontal ligament cells.

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2013: Kenji Kukita; Mami Nagatomo; Takahiko Oho; Yuichi Oogai; Yasuo Suda; Takuo Tanaka; Masahito Hashimoto; Miki Kawada-Matsuo; Hitoshi Komatsuzawa
Staphylococcus aureus SasA Is Responsible for Binding to the Salivary Agglutinin gp340, Derived from Human Saliva.
Infection and immunity 2013;81(6):1870-9.
2013: Naohiro Shimotahira; Sakuo Yamada; Fuminobu Yoshimura; Kenji Fukutsuji; Miki Kawada-Matsuo; Keiji Nagano; Kazuyuki Noguchi; Yuichi Oogai; Hitoshi Komatsuzawa
The surface layer of Tannerella forsythia contributes to serum resistance and oral bacterial coaggregation.
Infection and immunity 2013;81(4):1198-206.
2013: M Kittaka; Hitoshi Komatsuzawa; Kazuhisa Ouhara; Hideki Shiba; Katsuhiro Takeda; Tsuyoshi Fujita; M Kajiya; K Kanbara; Hiroyuki Kawaguchi; Hidemi Kurihara
Antimicrobial peptide LL37 promotes vascular endothelial growth factor-A expression in human periodontal ligament cells.
Journal of periodontal research 2013;48(2):228-34.
2013: Kei Fujishima; Miki Kawada-Matsuo; Yuichi Oogai; Masayuki Tokuda; Mitsuo Torii; Hitoshi Komatsuzawa
dpr and sod in Streptococcus mutans are involved in coexistence with S. sanguinis, and PerR is associated with resistance to H2O2.
Applied and environmental microbiology 2013;79(5):1436-43.
2012: Fumi Tateishi; Yuichi Oogai; Tsutomu Douchi; Kozue Hasegawa-Nakamura; Masayuki Hatae; Kazuya Kawamata; Hitoshi Komatsuzawa; Toshiaki Nakamura; Kazuyuki Noguchi
Detection of Fusobacterium nucleatum in chorionic tissues of high-risk pregnant women.
Journal of clinical periodontology 2012;39(5):417-24.
2012: Y Mazda; S Miyawaki; Y Oogai; Y Shibata; Y Yamashita; K Kanbara; M Kawada-Matsuo; Hitoshi Komatsuzawa
Association of CiaRH with resistance of Streptococcus mutans to antimicrobial peptides in biofilms.
Molecular oral microbiology 2012;27(2):124-35.
2012: G Tang; T Kawai; Hitoshi Komatsuzawa; Keith P Mintz
Lipopolysaccharides mediate leukotoxin secretion in Aggregatibacter actinomycetemcomitans.
Molecular oral microbiology 2012;27(2):70-82.
2012: Miki Kawada-Matsuo; Toshihisa Kawai; Mikihito Kajiya; Yusuke Mazda; Shouichi Miyawaki; Takahiko Oho; Yuichi Oogai; Sakuo Yamada; Hitoshi Komatsuzawa
GlmS and NagB regulate amino sugar metabolism in opposing directions and affect Streptococcus mutans virulence.
PloS one 2012;7(3):e33382.
2011: Yuichi Oogai; Motoyuki Sugai; Masahito Hashimoto; Fuminori Kato; Miki Matsuo; Hitoshi Komatsuzawa
Expression of virulence factors by Staphylococcus aureus grown in serum.
Applied and environmental microbiology 2011;77(22):8097-105.
2011: Miki Kawada-Matsuo; Norifumi Nakamura; Yuuma Yoshida; Hitoshi Komatsuzawa
Role of two-component systems in the resistance of Staphylococcus aureus to antibacterial agents.
Virulence 2011;2(5):427-30.
2011: Yoko Morimoto-Yamashita; Mitsuo Torii; Ko-ichi Kawahara; Kiyoshi Kikuchi; Hitoshi Komatsuzawa; Miki Matsuo; Masayuki Tokuda
MK615: a new therapeutic approach for the treatment of oral disease.
Medical hypotheses 2011;77(2):258-60.
2011: Yuuma Yoshida; Miki Matsuo; Yuichi Oogai; Fuminori Kato; Norifumi Nakamura; Motoyuki Sugai; Hitoshi Komatsuzawa
Bacitracin sensing and resistance in Staphylococcus aureus.
FEMS microbiology letters 2011;320(1):33-9.
2011: Miki Matsuo; Yuichi Oogai; Motoyuki Sugai; Fuminori Kato; Hitoshi Komatsuzawa
Growth-phase dependence of susceptibility to antimicrobial peptides in Staphylococcus aureus.
Microbiology (Reading, England) 2011;157(Pt 6):1786-97.
2011: Fuminori Kato; Noriko Kadomoto; Yuko Iwamoto; Katsuaki Bunai; Hitoshi Komatsuzawa; Motoyuki Sugai
Regulatory mechanism for exfoliative toxin production in Staphylococcus aureus.
Infection and immunity 2011;79(4):1660-70.
2011: Kouji Ohta; Mikihiko Kajiya; Tongbo Zhu; Hiromi Nishi; Hani Mawardi; Jane Shin; Leena Elbadawi; Nobuyuki Kamata; Hitoshi Komatsuzawa; Toshihisa Kawai
Additive effects of orexin B and vasoactive intestinal polypeptide on LL-37-mediated antimicrobial activities.
Journal of neuroimmunology 2011;233(1-2):37-45.
2011: Mikihito Kajiya; Hitoshi Komatsuzawa; Annatoula Papantonakis; Makoto Seki; Seicho Makihira; Kazuhisa Ouhara; Yutaka Kusumoto; Shinya Murakami; Martin A Taubman; Toshihisa Kawai
Aggregatibacter actinomycetemcomitans Omp29 is associated with bacterial entry to gingival epithelial cells by F-actin rearrangement.
PloS one 2011;6(4):e18287.
2010: Miki Matsuo; Fuminori Kato; Yuichi Oogai; Toshihisa Kawai; Motoyuki Sugai; Hitoshi Komatsuzawa
Distinct two-component systems in methicillin-resistant Staphylococcus aureus can change the susceptibility to antimicrobial agents.
The Journal of antimicrobial chemotherapy 2010;65(7):1536-7.
2010: Mikihito Kajiya; Hideki Shiba; Hitoshi Komatsuzawa; Kazuhisa Ouhara; Tsuyoshi Fujita; Katsuhiro Takeda; Yuushi Uchida; Noriyoshi Mizuno; Hiroyuki Kawaguchi; Hidemi Kurihara
The antimicrobial peptide LL37 induces the migration of human pulp cells: a possible adjunct for regenerative endodontics.
Journal of endodontics 2010;36(6):1009-13.
2009: P Thanyasrisung; Hitoshi Komatsuzawa; G Yoshimura; Tamaki Fujiwara; Sakuo Yamada; Katsuyuki Kozai; K Eto; Y Izumi; Motoyuki Sugai
Automutanolysin disrupts clinical isolates of cariogenic streptococci in biofilms and planktonic cells.
Oral microbiology and immunology 2009;24(6):451-5.
2009: Miki Matsuo; Hitoshi Komatsuzawa
[Strategy of Staphylococcus aureus infection to the host].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2009;54(8 Suppl):975-81.
2008: Masaru Ohara; Tomonori Hayashi; Yoichiro Kusunoki; Kei Nakachi; Tamaki Fujiwara; Hitoshi Komatsuzawa; Motoyuki Sugai
Cytolethal distending toxin induces caspase-dependent and -independent cell death in MOLT-4 cells.
Infection and immunity 2008;76(10):4783-91.
2008: A Kishimoto; Tsuyoshi Fujita; Hideki Shiba; Hitoshi Komatsuzawa; Katsuhiro Takeda; M Kajiya; K Hayashida; Hiroyuki Kawaguchi; Hidemi Kurihara
Irsogladine maleate abolishes the increase in interleukin-8 levels caused by outer membrane protein 29 from Aggregatibacter (Actinobacillus) actinomycetemcomitans through the ERK pathway in human gingival epithelial cells.
Journal of periodontal research 2008;43(5):508-13.
2008: Kazuhisa Ouhara; Hitoshi Komatsuzawa; Toshihisa Kawai; Hiromi Nishi; Tamaki Fujiwara; Yoshihiro Fujiue; Masao Kuwabara; Koji Sayama; Koji Hashimoto; Motoyuki Sugai
Increased resistance to cationic antimicrobial peptide LL-37 in methicillin-resistant strains of Staphylococcus aureus.
The Journal of antimicrobial chemotherapy 2008;61(6):1266-9.
2007: Masaya Tohyama; Koji Sayama; Hitoshi Komatsuzawa; Yasushi Hanakawa; Yuji Shirakata; Xjuju Dai; Lujun Yang; Sho Tokumaru; Hiroshi Nagai; Satoshi Hirakawa; Motoyuki Sugai; Koji Hashimoto
CXCL16 is a novel mediator of the innate immunity of epidermal keratinocytes.
International immunology 2007;19(9):1095-102.
2007: Shuntaro Kouda; Ryuichi Kuwahara; Masaru Ohara; Masanobu Shigeta; Tamaki Fujiwara; Hitoshi Komatsuzawa; Tsuguru Usui; Motoyuki Sugai
First isolation of blaIMP-7 in a Pseudomonas aeruginosa in Japan.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2007;13(4):276-7.
2007: Toshihisa Kawai; B J Paster; Hitoshi Komatsuzawa; C W O Ernst; Reginaldo Bruno Goncalves; H Sasaki; Kazuhisa Ouhara; Philip Stashenko; Motoyuki Sugai; Martin A Taubman
Cross-reactive adaptive immune response to oral commensal bacteria results in an induction of receptor activator of nuclear factor-kappaB ligand (RANKL)-dependent periodontal bone resorption in a mouse model.
Oral microbiology and immunology 2007;22(3):208-15.
2007: Hitoshi Komatsuzawa; Kazuhisa Ouhara; Toshihisa Kawai; Sakuo Yamada; Tamaki Fujiwara; Hideki Shiba; Hidemi Kurihara; Martin A Taubman; Motoyuki Sugai
Susceptibility of periodontopathogenic and cariogenic bacteria to defensins and potential therapeutic use of defensins in oral diseases.
Current pharmaceutical design 2007;13(30):3084-95.
2007: Masaru Ohara; Shuntaro Kouda; Makoto Onodera; Yoshihiro Fujiue; Megumi Sasaki; Tadahiro Kohara; Seiya Kashiyama; Shizue Hayashida; Manami Kadono; Hitoshi Komatsuzawa; Naomasa Gotoh; Tuguru Usui; Hideyuki Itaha; Masao Kuwabara; Takashi Yokoyama; Motoyuki Sugai
Molecular characterization of imipenem-resistant Pseudomonas aeruginosa in Hiroshima, Japan.
Microbiology and immunology 2007;51(3):271-7.
2006: Shuichi Nishikubo; Masaru Ohara; Masae Ikura; Katsuo Katayanagi; Tamaki Fujiwara; Hitoshi Komatsuzawa; Hidemi Kurihara; Motoyuki Sugai
Single nucleotide polymorphism in the cytolethal distending toxin B gene confers heterogeneity in the cytotoxicity of Actinobacillus actinomycetemcomitans.
Infection and immunity 2006;74(12):7014-20.
2006: I Hosokawa; Y Hosokawa; Hitoshi Komatsuzawa; Reginaldo Bruno Goncalves; Nadeem Y Karimbux; M H Napimoga; Makoto Seki; Kazuhisa Ouhara; Motoyuki Sugai; Martin A Taubman; Toshihisa Kawai
Innate immune peptide LL-37 displays distinct expression pattern from beta-defensins in inflamed gingival tissue.
Clinical and experimental immunology 2006;146(2):218-25.
2006: Kazuhisa Ouhara; Hitoshi Komatsuzawa; Hideki Shiba; Yushi Uchida; Toshihisa Kawai; Koji Sayama; Koji Hashimoto; Martin A Taubman; Hidemi Kurihara; Motoyuki Sugai
Actinobacillus actinomycetemcomitans outer membrane protein 100 triggers innate immunity and production of beta-defensin and the 18-kilodalton cationic antimicrobial protein through the fibronectin-integrin pathway in human gingival epithelial cells.
Infection and immunity 2006;74(9):5211-20.
2006: Hitoshi Komatsuzawa
[Analysis of the factors involved in cell wall biosynthesis in Staphylococcus aureus].
Nihon saikingaku zasshi. Japanese journal of bacteriology 2006;61(3):305-15.
2006: Yoko Ueno; Masaru Ohara; Toru Kawamoto; Tamaki Fujiwara; Hitoshi Komatsuzawa; Eric Oswald; Motoyuki Sugai
Biogenesis of the Actinobacillus actinomycetemcomitans cytolethal distending toxin holotoxin.
Infection and immunity 2006;74(6):3480-7.
2006: Jeff Zhiqiang Lu; Tamaki Fujiwara; Hitoshi Komatsuzawa; Motoyuki Sugai; Joshua Sakon
Cell wall-targeting domain of glycylglycine endopeptidase distinguishes among peptidoglycan cross-bridges.
The Journal of biological chemistry 2006;281(1):549-58.
2006: Goh Yoshimura; Hitoshi Komatsuzawa; Ikue Hayashi; Tamaki Fujiwara; Sakuo Yamada; Yoshio Nakano; Yuko Tomita; Katsuyuki Kozai; Motoyuki Sugai
Identification and molecular characterization of an N-Acetylmuraminidase, Aml, involved in Streptococcus mutans cell separation.
Microbiology and immunology 2006;50(9):729-42.
2006: Hitoshi Komatsuzawa; Kazuhisa Ouhara; Sakuo Yamada; Tamaki Fujiwara; Koji Sayama; Koji Hashimoto; Motoyuki Sugai
Innate defences against methicillin-resistant Staphylococcus aureus (MRSA) infection.
The Journal of pathology 2006;208(2):249-60.
2005: Junko Kajimura; Tamaki Fujiwara; Sakuo Yamada; Yoshika Suzawa; Tetsuya Nishida; Yoshihiro Oyamada; Ikue Hayashi; Jun-ichi Yamagishi; Hitoshi Komatsuzawa; Motoyuki Sugai
Identification and molecular characterization of an N-acetylmuramyl-L-alanine amidase Sle1 involved in cell separation of Staphylococcus aureus.
Molecular microbiology 2005;58(4):1087-101.
2005: Yasuhiro Fudaba; Koji Nishifuji; Lars Ole Andresen; Takayuki Yamaguchi; Hitoshi Komatsuzawa; Masayuki Amagai; Motoyuki Sugai
Staphylococcus hyicus exfoliative toxins selectively digest porcine desmoglein 1.
Microbial pathogenesis 2005;39(5-6):171-6.
2005: Sho Tokumaru; Koji Sayama; Yuji Shirakata; Hitoshi Komatsuzawa; Kazuhisa Ouhara; Yasushi Hanakawa; Yoko Yahata; Xiuju Dai; Masaya Tohyama; Hiroshi Nagai; Lujun Yang; Shigeki Higashiyama; Akihiko Yoshimura; Motoyuki Sugai; Koji Hashimoto
Induction of keratinocyte migration via transactivation of the epidermal growth factor receptor by the antimicrobial peptide LL-37.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(7):4662-8.
2005: Yuushi Uchida; Hideki Shiba; Hitoshi Komatsuzawa; Chikara Hirono; Arata Ashikaga; Tsuyoshi Fujita; Hiroyuki Kawaguchi; Motoyuki Sugai; Yoshiki Shiba; Hidemi Kurihara
Irsogladine maleate influences the response of gap junctional intercellular communication and IL-8 of human gingival epithelial cells following periodontopathogenic bacterial challenge.
Biochemical and biophysical research communications 2005;333(2):502-7.
2005: Kazuhisa Ouhara; Hitoshi Komatsuzawa; Sakuo Yamada; Hideki Shiba; Tamaki Fujiwara; Masaru Ohara; Koji Sayama; Koji Hashimoto; Hidemi Kurihara; Motoyuki Sugai
Susceptibilities of periodontopathogenic and cariogenic bacteria to antibacterial peptides, {beta}-defensins and LL37, produced by human epithelial cells.
The Journal of antimicrobial chemotherapy 2005;55(6):888-96.
2005: Koji Sayama; Hitoshi Komatsuzawa; Kenshi Yamasaki; Yuji Shirakata; Yasushi Hanakawa; Kazuhisa Ouhara; Sho Tokumaru; Xiuju Dai; Masaya Tohyama; Peter ten Dijke; Motoyuki Sugai; Hidenori Ichijo; Koji Hashimoto
New mechanisms of skin innate immunity: ASK1-mediated keratinocyte differentiation regulates the expression of beta-defensins, LL37, and TLR2.
European journal of immunology 2005;35(6):1886-95.
2005: Tamaki Fujiwara; Shin Aoki; Hitoshi Komatsuzawa; Tetsuya Nishida; Masaru Ohara; Hidekazu Suginaka; Motoyuki Sugai
Mutation analysis of the histidine residues in the glycylglycine endopeptidase ALE-1.
Journal of bacteriology 2005;187(2):480-7.
2004: Hiromi Nishi; Hitoshi Komatsuzawa; Tamaki Fujiwara; Nadine McCallum; Motoyuki Sugai
Reduced content of lysyl-phosphatidylglycerol in the cytoplasmic membrane affects susceptibility to moenomycin, as well as vancomycin, gentamicin, and antimicrobial peptides, in Staphylococcus aureus.
Antimicrobial agents and chemotherapy 2004;48(12):4800-7.
2004: Hitoshi Komatsuzawa
[Virulence of outer membrane proteins of periodontopathogenic bacteria].
Nihon saikingaku zasshi. Japanese journal of bacteriology 2004;59(3):473-82.
2004: Hitoshi Komatsuzawa; Tamaki Fujiwara; Hiromi Nishi; Sakuo Yamada; Masaru Ohara; Nadine McCallum; Brigitte Berger-Bächi; Motoyuki Sugai
The gate controlling cell wall synthesis in Staphylococcus aureus.
Molecular microbiology 2004;53(4):1221-31.
2004: Goh Yoshimura; Hitoshi Komatsuzawa; Junko Kajimura; Tamaki Fujiwara; Masaru Ohara; Katsuyuki Kozai; Motoyuki Sugai
Zymographic characterization of bacteriolytic enzymes produced by oral streptococci.
Microbiology and immunology 2004;48(6):465-9.
2003: Shuichi Nishikubo; Masaru Ohara; Yoko Ueno; Masae Ikura; Hidemi Kurihara; Hitoshi Komatsuzawa; Eric Oswald; Motoyuki Sugai
An N-terminal segment of the active component of the bacterial genotoxin cytolethal distending toxin B (CDTB) directs CDTB into the nucleus.
The Journal of biological chemistry 2003;278(50):50671-81.
2003: Takuji Noguchi; Hideki Shiba; Hitoshi Komatsuzawa; Noriyoshi Mizuno; Yuushi Uchida; Kazuhisa Ouhara; Ryuji Asakawa; Seiji Kudo; Hiroyuki Kawaguchi; Motoyuki Sugai; Hidemi Kurihara
Syntheses of prostaglandin E2 and E-cadherin and gene expression of beta-defensin-2 by human gingival epithelial cells in response to Actinobacillus actinomycetemcomitans.
Inflammation 2003;27(6):341-9.
2003: Ryuji Asakawa; Hitoshi Komatsuzawa; Toshihisa Kawai; Sakuo Yamada; Reginaldo Bruno Goncalves; Shunsuke Izumi; Tamaki Fujiwara; Yoshio Nakano; Nao Suzuki; Yuushi Uchida; Kazuhisa Ouhara; Hideki Shiba; Martin A Taubman; Hidemi Kurihara; Motoyuki Sugai
Outer membrane protein 100, a versatile virulence factor of Actinobacillus actinomycetemcomitans.
Molecular microbiology 2003;50(4):1125-39.
2003: Hideki Shiba; Yoshihiro Mouri; Hitoshi Komatsuzawa; Kazuhisa Ouhara; Katsuhiro Takeda; Motoyuki Sugai; Denis F Kinane; Hidemi Kurihara
Macrophage inflammatory protein-3alpha and beta-defensin-2 stimulate dentin sialophosphoprotein gene expression in human pulp cells.
Biochemical and biophysical research communications 2003;306(4):867-71.
2003: Kazushige Midorikawa; Kazuhisa Ouhara; Hitoshi Komatsuzawa; Toshihisa Kawai; Sakuo Yamada; Tamaki Fujiwara; Kenshi Yamazaki; Koji Sayama; Martin A Taubman; Hidemi Kurihara; Koji Hashimoto; Motoyuki Sugai
Staphylococcus aureus susceptibility to innate antimicrobial peptides, beta-defensins and CAP18, expressed by human keratinocytes.
Infection and immunity 2003;71(7):3730-9.
2003: Ryousuke Yamano; Masaru Ohara; Shuichi Nishikubo; Tamaki Fujiwara; Toru Kawamoto; Yoko Ueno; Hitoshi Komatsuzawa; Katsuji Okuda; Hidemi Kurihara; Hidekazu Suginaka; Eric Oswald; Kazuo Tanne; Motoyuki Sugai
Prevalence of cytolethal distending toxin production in periodontopathogenic bacteria.
Journal of clinical microbiology 2003;41(4):1391-8.
2003: Hiromi Nishi; Hitoshi Komatsuzawa; Sakuo Yamada; Tamaki Fujiwara; Masaru Ohara; Kouji Ohta; Masaru Sugiyama; Takenori Ishikawa; Motoyuki Sugai
Moenomycin-resistance is associated with vancomycin-intermediate susceptibility in Staphylococcus aureus.
Microbiology and immunology 2003;47(12):927-35.
2003: Hideki Shiba; Yoshihiro Mouri; Hitoshi Komatsuzawa; Noriyoshi Mizuno; Wanpeng Xu; Takuji Noguchi; Shigeo Nakamura; Motoyuki Sugai; Yukio Kato; Hidemi Kurihara
Enhancement of alkaline phosphatase synthesis in pulp cells co-cultured with epithelial cells derived from lower rabbit incisors.
Cell biology international 2003;27(10):815-23.
2002: Takayuki Yamaguchi; Koji Nishifuji; Megumi Sasaki; Yasuhiro Fudaba; Martin Aepfelbacher; Takashi Takata; Masaru Ohara; Hitoshi Komatsuzawa; Masayuki Amagai; Motoyuki Sugai
Identification of the Staphylococcus aureus etd pathogenicity island which encodes a novel exfoliative toxin, ETD, and EDIN-B.
Infection and immunity 2002;70(10):5835-45.
2002: Takayuki Yamaguchi; Yoshiko Yokota; Jun Terajima; Tetsuya Hayashi; Martin Aepfelbacher; Masaru Ohara; Hitoshi Komatsuzawa; Haruo Watanabe; Motoyuki Sugai
Clonal association of Staphylococcus aureus causing bullous impetigo and the emergence of new methicillin-resistant clonal groups in Kansai district in Japan.
The Journal of infectious diseases 2002;185(10):1511-6.
2002: Masatoshi Sakata; Hideki Shiba; Hitoshi Komatsuzawa; Tsuyoshi Fujita; Yuushi Uchida; Hiroshi Yoshino; Tetsuji Ogawa; Hiroyuki Kawaguchi; Hidemi Kurihara
Osteoprotegerin levels increased by interleukin-1beta in human periodontal ligament cells are suppressed through prostaglandin E(2) synthesized de novo.
Cytokine 2002;18(3):133-9.
2002: Hitoshi Komatsuzawa; Ryuji Asakawa; Toshihisa Kawai; Kyoko Ochiai; Tamaki Fujiwara; Martin A Taubman; Masaru Ohara; Hidemi Kurihara; Motoyuki Sugai
Identification of six major outer membrane proteins from Actinobacillus actinomycetemcomitans.
Gene 2002;288(1-2):195-201.
2002: Junko Takahashi; Hitoshi Komatsuzawa; Sakuo Yamada; Tetsuya Nishida; Harald Labischinski; Tamaki Fujiwara; Masaru Ohara; Jun-ichi Yamagishi; Motoyuki Sugai
Molecular characterization of an atl null mutant of Staphylococcus aureus.
Microbiology and immunology 2002;46(9):601-12.
2002: Hitoshi Komatsuzawa; Kouji Ohta; Sakuo Yamada; Kerstin Ehlert; Harald Labischinski; Junko Kajimura; Tamaki Fujiwara; Motoyuki Sugai
Increased glycan chain length distribution and decreased susceptibility to moenomycin in a vancomycin-resistant Staphylococcus aureus mutant.
Antimicrobial agents and chemotherapy 2002;46(1):75-81.
2001: Takayuki Yamaguchi; Tomonori Hayashi; H Takami; Makoto Ohnishi; T Murata; K Nakayama; K Asakawa; Masaru Ohara; Hitoshi Komatsuzawa; Motoyuki Sugai
Complete nucleotide sequence of a Staphylococcus aureus exfoliative toxin B plasmid and identification of a novel ADP-ribosyltransferase, EDIN-C.
Infection and immunity 2001;69(12):7760-71.
2001: Hitoshi Komatsuzawa; Kouji Ohta; Tamaki Fujiwara; GH Choi; Harald Labischinski; Motoyuki Sugai
Cloning and sequencing of the gene, fmtC, which affects oxacillin resistance in methicillin-resistant Staphylococcus aureus.
FEMS microbiology letters 2001;203(1):49-54.
2001: Yuushi Uchida; Hideki Shiba; Hitoshi Komatsuzawa; T Takemoto; Masatoshi Sakata; Tsuyoshi Fujita; Hiroyuki Kawaguchi; Motoyuki Sugai; Hidemi Kurihara
Expression of IL-1 beta and IL-8 by human gingival epithelial cells in response to Actinobacillus actinomycetemcomitans.
Cytokine 2001;14(3):152-61.
2000: T Yamaguchi; T Hayashi; H Takami; K Nakasone; Makoto Ohnishi; K Nakayama; Sakuo Yamada; Hitoshi Komatsuzawa; Motoyuki Sugai
Phage conversion of exfoliative toxin A production in Staphylococcus aureus.
Molecular microbiology 2000;38(4):694-705.
2000: Hitoshi Komatsuzawa; GH Choi; Tamaki Fujiwara; Y Huang; Kouji Ohta; Motoyuki Sugai; Hidekazu Suginaka
Identification of a fmtA-like gene that has similarity to other PBPs and beta-lactamases in Staphylococcus aureus.
FEMS microbiology letters 2000;188(1):35-9.
2000: Hitoshi Komatsuzawa; Kouji Ohta; Motoyuki Sugai; Tamaki Fujiwara; P Glanzmann; Hidekazu Suginaka
Tn551-mediated insertional inactivation of the fmtB gene encoding a cell wall-associated protein abolishes methicillin resistance in Staphylococcus aureus.
The Journal of antimicrobial chemotherapy 2000;45(4):421-31.
2000: Kouji Ohta; Hitoshi Komatsuzawa; Motoyuki Sugai; Hidekazu Suginaka
Triton X-100-induced lipoteichoic acid release is correlated with the methicillin resistance in Staphylococcus aureus.
FEMS microbiology letters 2000;182(1):77-9.
2000: G Tanaka; M Shigeta; Hitoshi Komatsuzawa; Motoyuki Sugai; Hidekazu Suginaka; Tuguru Usui
Effect of clarithromycin on Pseudomonas aeruginosa biofilms.
Chemotherapy 2000;46(1):36-42.
1999: Motoyuki Sugai; K Hatazaki; A Mogami; H Ohta; SY Pérès; Fréderique Hérault; Yasuhiko Horiguchi; M Masuda; Yoko Ueno; Hitoshi Komatsuzawa; Hidekazu Suginaka; Eric Oswald
Cytotoxic necrotizing factor type 2 produced by pathogenic Escherichia coli deamidates a gln residue in the conserved G-3 domain of the rho family and preferentially inhibits the GTPase activity of RhoA and rac1.
Infection and immunity 1999;67(12):6550-7.
1999: Hitoshi Komatsuzawa; Kouji Ohta; Harald Labischinski; Motoyuki Sugai; Hidekazu Suginaka
Characterization of fmtA, a gene that modulates the expression of methicillin resistance in Staphylococcus aureus.
Antimicrobial agents and chemotherapy 1999;43(9):2121-5.
1999: Masatoshi Sakata; Hideki Shiba; Hitoshi Komatsuzawa; Tsuyoshi Fujita; K Ohta; Motoyuki Sugai; Hidekazu Suginaka; Hidemi Kurihara
Expression of osteoprotegerin (osteoclastogenesis inhibitory factor) in cultures of human dental mesenchymal cells and epithelial cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1999;14(9):1486-92.
1999: Hitoshi Komatsuzawa; GH Choi; Kouji Ohta; Motoyuki Sugai; M T Tran; Hidekazu Suginaka
Cloning and characterization of a gene, pbpF, encoding a new penicillin-binding protein, PBP2B, in Staphylococcus aureus.
Antimicrobial agents and chemotherapy 1999;43(7):1578-83.
1999: P Glanzmann; J Gustafson; Hitoshi Komatsuzawa; Kouji Ohta; Brigitte Berger-Bächi
glmM operon and methicillin-resistant glmM suppressor mutants in Staphylococcus aureus.
Antimicrobial agents and chemotherapy 1999;43(2):240-5.
1999: Hitoshi Komatsuzawa; Toshihisa Kawai; Mark E Wilson; Martin A Taubman; Motoyuki Sugai; Hidekazu Suginaka
Cloning of the gene encoding the Actinobacillus actinomycetemcomitans serotype b OmpA-like outer membrane protein.
Infection and immunity 1999;67(2):942-5.
1999: G Tanaka; M Shigeta; Hitoshi Komatsuzawa; Motoyuki Sugai; Hidekazu Suginaka; Tuguru Usui
Effect of the growth rate of Pseudomonas aeruginosa biofilms on the susceptibility to antimicrobial agents: beta-lactams and fluoroquinolones.
Chemotherapy 1999;45(1):28-36.
1998: Motoyuki Sugai; Tamaki Fujiwara; Hitoshi Komatsuzawa
Identification and molecular characterization of a gene homologous to epr (endopeptidase resistance gene) in Staphylococcus aureus.
Gene 1998;224(1-2):67-75.
1998: Motoyuki Sugai; Toru Kawamoto; SY Pérès; Yoko Ueno; Hitoshi Komatsuzawa; Tamaki Fujiwara; Hidemi Kurihara; Hidekazu Suginaka; Eric Oswald
The cell cycle-specific growth-inhibitory factor produced by Actinobacillus actinomycetemcomitans is a cytolethal distending toxin.
Infection and immunity 1998;66(10):5008-19.
1998: Chiharu Shirai; Motoyuki Sugai; Hitoshi Komatsuzawa; Kouji Ohta; Michio Yamakido; Hidekazu Suginaka
The mechanism of sensitizing effect of a triazine dye, cibacron blue F3GA, on methicillin-resistant Staphylococcus aureus to oxacillin.
Hiroshima journal of medical sciences 1998;47(2):73-83.
1998: Chiharu Shirai; Motoyuki Sugai; Hitoshi Komatsuzawa; Kouji Ohta; Michio Yamakido; Hidekazu Suginaka
A triazine dye, cibacron blue F3GA, decreases oxacillin resistance levels in methicillin-resistant Staphylococcus aureus.
Antimicrobial agents and chemotherapy 1998;42(5):1278-80.
1998: K Hatazaki; M Sugai; H Momota; H Ohgai; Hitoshi Komatsuzawa; Hidekazu Suginaka
Expression and purification of epidermal cell differentiation inhibitor (EDIN) from Bacillus subtilis.
Protein expression and purification 1998;12(2):284-90.
1998: Kouji Ohta; Hitoshi Komatsuzawa; Motoyuki Sugai; Hidekazu Suginaka
Zymographic characterization of Staphylococcus aureus cell wall.
Microbiology and immunology 1998;42(3):231-5.
1997: Hitoshi Komatsuzawa; Motoyuki Sugai; Kouji Ohta; Tamaki Fujiwara; S Nakashima; Junji Suzuki; C Y Lee; Hidekazu Suginaka
Cloning and characterization of the fmt gene which affects the methicillin resistance level and autolysis in the presence of triton X-100 in methicillin-resistant Staphylococcus aureus.
Antimicrobial agents and chemotherapy 1997;41(11):2355-61.
1997: M Shigeta; G Tanaka; Hitoshi Komatsuzawa; Motoyuki Sugai; Hidekazu Suginaka; Tuguru Usui
Permeation of antimicrobial agents through Pseudomonas aeruginosa biofilms: a simple method.
Chemotherapy 1997;43(5):340-5.
1997: Junji Suzuki; Hitoshi Komatsuzawa; Motoyuki Sugai; Kouji Ohta; Katsuyuki Kozai; Naohiro Nagasaka; Hidekazu Suginaka
Effects of various types of Triton X on the susceptibilities of methicillin-resistant staphylococci to oxacillin.
FEMS microbiology letters 1997;153(2):327-31.
1997: Junji Suzuki; Hitoshi Komatsuzawa; Katsuyuki Kozai; Naohiro Nagasaka
In vitro susceptibility of Staphylococcus aureus including MRSA to four disinfectants.
ASDC journal of dentistry for children 1997;64(4):260-3.
1997: Motoyuki Sugai; Tamaki Fujiwara; Kouji Ohta; Hitoshi Komatsuzawa; Masaru Ohara; Hidekazu Suginaka
epr, which encodes glycylglycine endopeptidase resistance, is homologous to femAB and affects serine content of peptidoglycan cross bridges in Staphylococcus capitis and Staphylococcus aureus.
Journal of bacteriology 1997;179(13):4311-8.
1997: Motoyuki Sugai; Sakuo Yamada; S Nakashima; Hitoshi Komatsuzawa; A Matsumoto; T Oshida; Hidekazu Suginaka
Localized perforation of the cell wall by a major autolysin: atl gene products and the onset of penicillin-induced lysis of Staphylococcus aureus.
Journal of bacteriology 1997;179(9):2958-62.
1997: M Shigeta; Hitoshi Komatsuzawa; Motoyuki Sugai; Hidekazu Suginaka; Tuguru Usui
Effect of the growth rate of Pseudomonas aeruginosa biofilms on the susceptibility to antimicrobial agents.
Chemotherapy 1997;43(2):137-41.
1997: Motoyuki Sugai; Tamaki Fujiwara; T Akiyama; Masaru Ohara; Hitoshi Komatsuzawa; S Inoue; Hidekazu Suginaka
Purification and molecular characterization of glycylglycine endopeptidase produced by Staphylococcus capitis EPK1.
Journal of bacteriology 1997;179(4):1193-202.
1997: Junji Suzuki; Hitoshi Komatsuzawa; Motoyuki Sugai; T Suzuki; Katsuyuki Kozai; Y Miyake; Hidekazu Suginaka; Naohiro Nagasaka
A long-term survey of methicillin-resistant Staphylococcus aureus in the oral cavity of children.
Microbiology and immunology 1997;41(9):681-6.
1997: Hitoshi Komatsuzawa; Motoyuki Sugai; S Nakashima; Sakuo Yamada; A Matsumoto; T Oshida; Hidekazu Suginaka
Subcellular localization of the major autolysin, ATL and its processed proteins in Staphylococcus aureus.
Microbiology and immunology 1997;41(6):469-79.
1996: Sakuo Yamada; Motoyuki Sugai; Hitoshi Komatsuzawa; S Nakashima; T Oshida; Akira Matsumoto; Hidekazu Suginaka
An autolysin ring associated with cell separation of Staphylococcus aureus.
Journal of bacteriology 1996;178(6):1565-71.
1996: T Matsuura; Y Miyake; S Nakashima; Hitoshi Komatsuzawa; Y Akagawa; Hidekazu Suginaka
Isolation and characterization of teichoic acid-lake substance as an adhesin of Staphylococcus aureus to HeLa cells.
Microbiology and immunology 1996;40(4):247-54.
1995: Hitoshi Komatsuzawa; Motoyuki Sugai; Chiharu Shirai; Junji Suzuki; K Hiramatsu; Hidekazu Suginaka
Triton X-100 alters the resistance level of methicillin-resistant Staphylococcus aureus to oxacillin.
FEMS microbiology letters 1995;134(2-3):209-12.
1995: Motoyuki Sugai; Hitoshi Komatsuzawa; T Akiyama; Y M Hong; T Oshida; Y Miyake; T Yamaguchi; Hidekazu Suginaka
Identification of endo-beta-N-acetylglucosaminidase and N-acetylmuramyl-L-alanine amidase as cluster-dispersing enzymes in Staphylococcus aureus.
Journal of bacteriology 1995;177(6):1491-6.
1995: T Oshida; Motoyuki Sugai; Hitoshi Komatsuzawa; Y M Hong; Hidekazu Suginaka; Alexander Tomasz
A Staphylococcus aureus autolysin that has an N-acetylmuramoyl-L-alanine amidase domain and an endo-beta-N-acetylglucosaminidase domain: cloning, sequence analysis, and characterization.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(1):285-9.
1995: Hitoshi Komatsuzawa; Motoyuki Sugai; S Nakashima; Hidekazu Suginaka
Alteration of bacteriolytic enzyme profile of Staphylococcus aureus during growth.
Microbiology and immunology 1995;39(8):629-33.
1994: Hitoshi Komatsuzawa; Junji Suzuki; Motoyuki Sugai; Y Miyake; Hidekazu Suginaka
The effect of Triton X-100 on the in-vitro susceptibility of methicillin-resistant Staphylococcus aureus to oxacillin.
The Journal of antimicrobial chemotherapy 1994;34(6):885-97.
1994: Hitoshi Komatsuzawa; Junji Suzuki; Motoyuki Sugai; Y Miyake; Hidekazu Suginaka
Effect of combination of oxacillin and non-beta-lactam antibiotics on methicillin-resistant Staphylococcus aureus.
The Journal of antimicrobial chemotherapy 1994;33(6):1155-63.
1994: Motoyuki Sugai; Hitoshi Komatsuzawa; K Ooku-Inomata; Y Miyake; E Ishida; Hidekazu Suginaka
Isolation and characterization of Staphylococcus aureus mutants which form altered cell clusters.
Microbiology and immunology 1994;38(12):995-9.
1991: Motoyuki Sugai; Hitoshi Komatsuzawa; Y Miyake; Hidekazu Suginaka
Visualization of endo-beta-N-acetylglucosaminidase, lysozyme, and lysostaphin after polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulphate.
Zentralblatt für Bakteriologie : international journal of medical microbiology 1991;275(2):156-61.
1991: M Sugai; T Akiyama; Hitoshi Komatsuzawa; Y Miyake; Hidekazu Suginaka
Cibacron blue 3G-A inhibits cell separation of gram-positive bacteria.
Archives of microbiology 1991;155(2):199-201.
1990: Motoyuki Sugai; T Akiyama; Hitoshi Komatsuzawa; Y Miyake; Hidekazu Suginaka
Characterization of sodium dodecyl sulfate-stable Staphylococcus aureus bacteriolytic enzymes by polyacrylamide gel electrophoresis.
Journal of bacteriology 1990;172(11):6494-8.