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Elizabeth Komives

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Genes & Molecular Sequences

Amino Acid Sequence

Concepts & Ideas

Chemicals & Drugs

Phenomena

Protein Binding

Physiology

Protein Folding

Procedures

Occupations

Thermodynamics

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Co-Publications
Name
9
Mandell, Jeffrey
8
Baerga-Ortiz, Abel
7
Petsko, Gregory
6
Koeppe, Julia
6
Ferreiro, Diego
6
Torpey, Justin
6
Truhlar, Stephanie
6
Vold, Regitze
5
Wolynes, Peter
5
Wood, Matthew
5
ghosh, riya
5
Croy, Carrie H.
5
Glover, Kerney Jebrell
5
Anand, Ganesh
4
Hughes, Carrie

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Publications

TOP 3
Sung Dong-Yul; Kim Tae-Houn; Komives Elizabeth A; Mendoza-Cózatl David G; Schroeder Julian I
ARS5 is a component of the 26S proteasome complex, and negatively regulates thiol biosynthesis and arsenic tolerance in Arabidopsis.
Cervantes Carla F; Markwick Phineus R L; Sue Shih-Che; McCammon J Andrew; Dyson H Jane; Komives Elizabeth A
Functional dynamics of the folded ankyrin repeats of I kappa B alpha revealed by nuclear magnetic resonance.
Gertsman Ilya; Gan Lu; Guttman Miklos; Lee Kelly; Speir Jeffrey A; Duda Robert L; Hendrix Roger W; Komives Elizabeth A; Johnson John E
An unexpected twist in viral capsid maturation.

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All Publications

2009: Sung Dong-Yul; Kim Tae-Houn; Komives Elizabeth A; Mendoza-Cózatl David G; Schroeder Julian I
ARS5 is a component of the 26S proteasome complex, and negatively regulates thiol biosynthesis and arsenic tolerance in Arabidopsis.
The Plant journal : for cell and molecular biology 2009;59(5):802-13.
2009: Cervantes Carla F; Markwick Phineus R L; Sue Shih-Che; McCammon J Andrew; Dyson H Jane; Komives Elizabeth A
Functional dynamics of the folded ankyrin repeats of I kappa B alpha revealed by nuclear magnetic resonance.
Biochemistry 2009;48(33):8023-31.
2009: Gertsman Ilya; Gan Lu; Guttman Miklos; Lee Kelly; Speir Jeffrey A; Duda Robert L; Hendrix Roger W; Komives Elizabeth A; Johnson John E
An unexpected twist in viral capsid maturation.
Nature 2009;458(7238):646-50.
2008: Bergqvist Simon; Ghosh Gourisankar; Komives Elizabeth A
The IkappaBalpha/NF-kappaB complex has two hot spots, one at either end of the interface.
Protein science : a publication of the Protein Society 2008;17(12):2051-8.
2008: Koeppe Julia R; Beach Muneera A; Baerga-Ortiz Abel; Kerns S Jordan; Komives Elizabeth A
Mutations in the fourth EGF-like domain affect thrombomodulin-induced changes in the active site of thrombin.
Biochemistry 2008;47(41):10933-9.
2008: Truhlar Stephanie M E; Cervantes Carla F; Torpey Justin W; Kjaergaard Magnus; Komives Elizabeth A
Rapid mass spectrometric analysis of 15N-Leu incorporation fidelity during preparation of specifically labeled NMR samples.
Protein science : a publication of the Protein Society 2008;17(9):1636-9.
2008: Sue Shih-Che; Cervantes Carla; Komives Elizabeth A; Dyson H Jane
Transfer of flexibility between ankyrin repeats in IkappaB* upon formation of the NF-kappaB complex.
Journal of molecular biology 2008;380(5):917-31.
2008: Truhlar Stephanie M E; Mathes Erika; Cervantes Carla F; Ghosh Gourisankar; Komives Elizabeth A
Pre-folding IkappaBalpha alters control of NF-kappaB signaling.
Journal of molecular biology 2008;380(1):67-82.
2008: Betts Gina N; van der Geer Peter; Komives Elizabeth A
Structural and functional consequences of tyrosine phosphorylation in the LRP1 cytoplasmic domain.
The Journal of biological chemistry 2008;283(23):15656-64.
2008: Ferreiro Diego U; Walczak Aleksandra M; Komives Elizabeth A; Wolynes Peter G
The energy landscapes of repeat-containing proteins: topology, cooperativity, and the folding funnels of one-dimensional architectures.
PLoS computational biology 2008;4(5):e1000070.
2008: Truhlar Stephanie M E; Komives Elizabeth A
LRR domain folding: just put a cap on it!
Structure (London, England : 1993) 2008;16(5):655-7.
2008: Huang Chun-Ming; Torpey Justin W; Liu Yu-Tseung; Chen Yun-Ru; Williams Katherine E; Komives Elizabeth A; Gallo Richard L
A peptide with a ProGln C terminus in the human saliva peptidome exerts bactericidal activity against Propionibacterium acnes.
Antimicrobial agents and chemotherapy 2008;52(5):1834-6.
2008: Mendoza-Cózatl David G; Butko Emerald; Springer Franziska; Torpey Justin W; Komives Elizabeth A; Kehr Julia; Schroeder Julian I
Identification of high levels of phytochelatins, glutathione and cadmium in the phloem sap of Brassica napus. A role for thiol-peptides in the long-distance transport of cadmium and the effect of cadmium on iron translocation.
The Plant journal : for cell and molecular biology 2008;54(2):249-59.
2008: Barrick Doug; Ferreiro Diego U; Komives Elizabeth A
Folding landscapes of ankyrin repeat proteins: experiments meet theory.
Current opinion in structural biology 2008;18(1):27-34.
2007: Ferreiro Diego U; Hegler Joseph A; Komives Elizabeth A; Wolynes Peter G
Localizing frustration in native proteins and protein assemblies.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(50):19819-24.
2007: Anand Ganesh S; Hotchko Matthew; Brown Simon H J; Ten Eyck Lynn F; Komives Elizabeth A; Taylor Susan S
R-subunit isoform specificity in protein kinase A: distinct features of protein interfaces in PKA types I and II by amide H/2H exchange mass spectrometry.
Journal of molecular biology 2007;374(2):487-99.
2007: Wu Xiaohua; Li Zhi-fang; Brooks Randolph; Komives Elizabeth A; Torpey Justin W; Engvall Eva; Gonias Steven L; Shelton G Diane
Autoantibodies in canine masticatory muscle myositis recognize a novel myosin binding protein-C family member.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4939-44.
2007: Ferreiro Diego U; Komives Elizabeth A
The plastic landscape of repeat proteins.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(19):7735-6.
2007: Sung Dong-Yul; Lee David; Harris Hugh; Raab Andrea; Feldmann Jörg; Meharg Andrew; Kumabe Bryan; Komives Elizabeth A; Schroeder Julian I
Identification of an arsenic tolerant double mutant with a thiol-mediated component and increased arsenic tolerance in phyA mutants.
The Plant journal : for cell and molecular biology 2007;49(6):1064-75.
2007: Lätzer Joachim; Papoian Garegin A; Prentiss Michael C; Komives Elizabeth A; Wolynes Peter G
Induced fit, folding, and recognition of the NF-kappaB-nuclear localization signals by IkappaBalpha and IkappaBbeta.
Journal of molecular biology 2007;367(1):262-74.
2007: Ferreiro Diego U; Cervantes Carla F; Truhlar Stephanie M E; Cho Samuel S; Wolynes Peter G; Komives Elizabeth A
Stabilizing IkappaBalpha by "consensus" design.
Journal of molecular biology 2007;365(4):1201-16.
2006: Truhlar Stephanie M E; Torpey Justin W; Komives Elizabeth A
Regions of IkappaBalpha that are critical for its inhibition of NF-kappaB.DNA interaction fold upon binding to NF-kappaB.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(50):18951-6.
2006: Truhlar Stephanie M E; Croy Carrie H; Torpey Justin W; Koeppe Julia R; Komives Elizabeth A
Solvent accessibility of protein surfaces by amide H/2H exchange MALDI-TOF mass spectrometry.
Journal of the American Society for Mass Spectrometry 2006;17(11):1490-7.
2006: Bergqvist Simon; Croy Carrie H; Kjaergaard Magnus; Huxford Tom; Ghosh Gourisankar; Komives Elizabeth A
Thermodynamics reveal that helix four in the NLS of NF-kappaB p65 anchors IkappaBalpha, forming a very stable complex.
Journal of molecular biology 2006;360(2):421-34.
2006: Koeppe Julia R; Komives Elizabeth A
Amide H/2H exchange reveals a mechanism of thrombin activation.
Biochemistry 2006;45(25):7724-32.
2006: Chen Alice; Komives Elizabeth A; Schroeder Julian I
An improved grafting technique for mature Arabidopsis plants demonstrates long-distance shoot-to-root transport of phytochelatins in Arabidopsis.
Plant physiology 2006;141(1):108-20.
2006: Shi Jianxin; Koeppe Julia R; Komives Elizabeth A; Taylor Palmer
Ligand-induced conformational changes in the acetylcholine-binding protein analyzed by hydrogen-deuterium exchange mass spectrometry.
The Journal of biological chemistry 2006;281(17):12170-7.
2006: Hotchko Matthew; Anand Ganesh S; Komives Elizabeth A; Ten Eyck Lynn F
Automated extraction of backbone deuteration levels from amide H/2H mass spectrometry experiments.
Protein science : a publication of the Protein Society 2006;15(3):583-601.
2005: Ferreiro Diego U; Cho Samuel S; Komives Elizabeth A; Wolynes Peter G
The energy landscape of modular repeat proteins: topology determines folding mechanism in the ankyrin family.
Journal of molecular biology 2005;354(3):679-92.
2005: Koeppe Julia R; Seitova Almagoul; Mather Timothy; Komives Elizabeth A
Thrombomodulin tightens the thrombin active site loops to promote protein C activation.
Biochemistry 2005;44(45):14784-91.
2005: Mandell Jeffrey G; Baerga-Ortiz Abel; Croy Carrie H; Falick Arnold M; Komives Elizabeth A
Application of amide proton exchange mass spectrometry for the study of protein-protein interactions.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2005;Chapter 20():Unit20.9.
2005: Prieto Judith H; Sampoli Benitez Benedetta A; Melacini Giuseppe; Johnson David A; Wood Matthew J; Komives Elizabeth A
Dynamics of the fragment of thrombomodulin containing the fourth and fifth epidermal growth factor-like domains correlate with function.
Biochemistry 2005;44(4):1225-33.
2005: Wood Matthew J; Helena Prieto Judith; Komives Elizabeth A
Structural and functional consequences of methionine oxidation in thrombomodulin.
Biochimica et biophysica acta 2005;1703(2):141-7.
2005: Mandell Jeffrey G; Baerga-Ortiz Abel; Falick Arnold M; Komives Elizabeth A
Measurement of solvent accessibility at protein-protein interfaces.
Methods in molecular biology (Clifton, N.J.) 2005;305():65-80.
2004: Croy Carrie Hughes; Bergqvist Simon; Huxford Tom; Ghosh Gourisankar; Komives Elizabeth A
Biophysical characterization of the free IkappaBalpha ankyrin repeat domain in solution.
Protein science : a publication of the Protein Society 2004;13(7):1767-77.
2004: Croy Johnny E; Brandon Theodore; Komives Elizabeth A
Two apolipoprotein E mimetic peptides, ApoE(130-149) and ApoE(141-155)2, bind to LRP1.
Biochemistry 2004;43(23):7328-35.
2004: Croy Carrie Hughes; Koeppe Julia R; Bergqvist Simon; Komives Elizabeth A
Allosteric changes in solvent accessibility observed in thrombin upon active site occupation.
Biochemistry 2004;43(18):5246-55.
2004: Baerga-Ortiz Abel; Bergqvist Simon; Mandell Jeffrey G; Komives Elizabeth A
Two different proteins that compete for binding to thrombin have opposite kinetic and thermodynamic profiles.
Protein science : a publication of the Protein Society 2004;13(1):166-76.
2003: Croy Johnny E; Shin William D; Knauer Mary F; Knauer Daniel J; Komives Elizabeth A
All three LDL receptor homology regions of the LDL receptor-related protein bind multiple ligands.
Biochemistry 2003;42(44):13049-57.
2003: Anand Ganesh S; Law Dennis; Mandell Jeffrey G; Snead Aaron N; Tsigelny Igor; Taylor Susan S; Ten Eyck Lynn F; Komives Elizabeth A
Identification of the protein kinase A regulatory RIalpha-catalytic subunit interface by amide H/2H exchange and protein docking.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(23):13264-9.
2003: Wood Matthew J; Becvar L Amaya; Prieto Judith Helena; Melacini Giuseppe; Komives Elizabeth A
NMR structures reveal how oxidation inactivates thrombomodulin.
Biochemistry 2003;42(41):11932-42.
2003: Jennings Lori L; Malecki Michael; Komives Elizabeth A; Taylor Palmer
Direct analysis of the kinetic profiles of organophosphate-acetylcholinesterase adducts by MALDI-TOF mass spectrometry.
Biochemistry 2003;42(37):11083-91.
2002: Huxford Tom; Mishler Dennis; Phelps Christopher B; Huang De-Bin; Sengchanthalangsy Lei Lei; Reeves Ryan; Hughes Carrie A; Komives Elizabeth A; Ghosh Gourisankar
Solvent exposed non-contacting amino acids play a critical role in NF-kappaB/IkappaBalpha complex formation.
Journal of molecular biology 2002;324(4):587-97.
2002: Anand Ganesh S; Hughes Carrie A; Jones John M; Taylor Susan S; Komives Elizabeth A
Amide H/2H exchange reveals communication between the cAMP and catalytic subunit-binding sites in the R(I)alpha subunit of protein kinase A.
Journal of molecular biology 2002;323(2):377-86.
2002: Whiles Jennifer A; Glover Kerney J; Vold Regitze R; Komives Elizabeth A
Methods for studying transmembrane peptides in bicelles: consequences of hydrophobic mismatch and peptide sequence.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2002;158(1-2):149-56.
2002: Baerga-Ortiz Abel; Hughes Carrie A; Mandell Jeffrey G; Komives Elizabeth A
Epitope mapping of a monoclonal antibody against human thrombin by H/D-exchange mass spectrometry reveals selection of a diverse sequence in a highly conserved protein.
Protein science : a publication of the Protein Society 2002;11(6):1300-8.
2001: Glover K J; Whiles J A; Wood M J; Melacini G; Komives E A; Vold R R
Conformational dimorphism and transmembrane orientation of prion protein residues 110-136 in bicelles.
Biochemistry 2001;40(44):13137-42.
2001: Glover K J; Whiles J A; Wu G; Yu N; Deems R; Struppe J O; Stark R E; Komives E A; Vold R R
Structural evaluation of phospholipid bicelles for solution-state studies of membrane-associated biomolecules.
Biophysical journal 2001;81(4):2163-71.
2001: Hughes C A; Mandell J G; Anand G S; Stock A M; Komives E A
Phosphorylation causes subtle changes in solvent accessibility at the interdomain interface of methylesterase CheB.
Journal of molecular biology 2001;307(4):967-76.
2001: Mandell J G; Baerga-Ortiz A; Akashi S; Takio K; Komives E A
Solvent accessibility of the thrombin-thrombomodulin interface.
Journal of molecular biology 2001;306(3):575-89.
2001: Whiles J A; Brasseur R; Glover K J; Melacini G; Komives E A; Vold R R
Orientation and effects of mastoparan X on phospholipid bicelles.
Biophysical journal 2001;80(1):280-93.
2000: Sampoli Benitez B A; Komives E A
Disulfide bond plasticity in epidermal growth factor.
Proteins 2000;40(1):168-74.
2000: Wood M J; Sampoli Benitez B A; Komives E A
Solution structure of the smallest cofactor-active fragment of thrombomodulin.
Nature structural biology 2000;7(3):200-4.
2000: Baerga-Ortiz A; Rezaie A R; Komives E A
Electrostatic dependence of the thrombin-thrombomodulin interaction.
Journal of molecular biology 2000;296(2):651-8.
1999: Glover K J; Martini P M; Vold R R; Komives E A
Preparation of insoluble transmembrane peptides: glycophorin-A, prion (110-137), and FGFR (368-397).
Analytical biochemistry 1999;272(2):270-4.
1999: Zhang Z; Komives E A; Sugio S; Blacklow S C; Narayana N; Xuong N H; Stock A M; Petsko G A; Ringe D
The role of water in the catalytic efficiency of triosephosphate isomerase.
Biochemistry 1999;38(14):4389-97.
1999: Mentz S; de Lacalle S; Baerga-Ortiz A; Knauer M F; Knauer D J; Komives E A
Mechanism of thrombin clearance by human astrocytoma cells.
Journal of neurochemistry 1999;72(3):980-7.
1999: Wood M J; Komives E A
Production of large quantities of isotopically labeled protein in Pichia pastoris by fermentation.
Journal of biomolecular NMR 1999;13(2):149-59.
1998: Mandell J G; Falick A M; Komives E A
Identification of protein-protein interfaces by decreased amide proton solvent accessibility.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(25):14705-10.
1998: Struppe J; Komives E A; Taylor S S; Vold R R
2H NMR studies of a myristoylated peptide in neutral and acidic phospholipid bicelles.
Biochemistry 1998;37(44):15523-7.
1998: Mandell J G; Falick A M; Komives E A
Measurement of amide hydrogen exchange by MALDI-TOF mass spectrometry.
Analytical chemistry 1998;70(19):3987-95.
1998: Gleeson M A; White C E; Meininger D P; Komives E A
Generation of protease-deficient strains and their use in heterologous protein expression.
Methods in molecular biology (Clifton, N.J.) 1998;103():81-94.
1997: Sampoli Benitez B A; Hunter M J; Meininger D P; Komives E A
Structure of the fifth EGF-like domain of thrombomodulin: An EGF-like domain with a novel disulfide-bonding pattern.
Journal of molecular biology 1997;273(4):913-26.
1997: Vindigni A; White C E; Komives E A; Di Cera E
Energetics of thrombin-thrombomodulin interaction.
Biochemistry 1997;36(22):6674-81.
1996: Komives E A; Lougheed J C; Zhang Z; Sugio S; Narayana N; Xuong N H; Petsko G A; Ringe D
The structural basis for pseudoreversion of the H95N lesion by the secondary S96P mutation in triosephosphate isomerase.
Biochemistry 1996;35(48):15474-84.
1996: White C E; Hunter M J; Meininger D P; Garrod S; Komives E A
The fifth epidermal growth factor-like domain of thrombomodulin does not have an epidermal growth factor-like disulfide bonding pattern.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(19):10177-82.
1995: White C E; Hunter M J; Meininger D P; White L R; Komives E A
Large-scale expression, purification and characterization of small fragments of thrombomodulin: the roles of the sixth domain and of methionine 388.
Protein engineering 1995;8(11):1177-87.
1995: Hunter M J; Komives E A
Thrombin-binding affinities of different disulfide-bonded isomers of the fifth EGF-like domain of thrombomodulin.
Protein science : a publication of the Protein Society 1995;4(10):2129-37.
1995: Komives E A; Lougheed J C; Liu K; Sugio S; Zhang Z; Petsko G A; Ringe D
The structural basis for pseudoreversion of the E165D lesion by the secondary S96P mutation in triosephosphate isomerase depends on the positions of active site water molecules.
Biochemistry 1995;34(41):13612-21.
1995: Meininger D P; Hunter M J; Komives E A
Synthesis, activity, and preliminary structure of the fourth EGF-like domain of thrombomodulin.
Protein science : a publication of the Protein Society 1995;4(9):1683-95.
1995: Hunter M J; Komives E A
Deprotection of S-acetamidomethyl cysteine-containing peptides by silver trifluoromethanesulfonate avoids the oxidation of methionines.
Analytical biochemistry 1995;228(1):173-7.
1995: Lougheed J C; Bowman C L; Meininger D P; Komives E A
Thrombin inhibition by cyclic peptides from thrombomodulin.
Protein science : a publication of the Protein Society 1995;4(4):773-80.
1994: White C E; Kempi N M; Komives E A
Expression of highly disulfide-bonded proteins in Pichia pastoris.
Structure (London, England : 1993) 1994;2(11):1003-5.
1994: Zhang Z; Sugio S; Komives E A; Liu K D; Knowles J R; Petsko G A; Ringe D
Crystal structure of recombinant chicken triosephosphate isomerase-phosphoglycolohydroxamate complex at 1.8-A resolution.
Biochemistry 1994;33(10):2830-7.
1994: Joseph-McCarthy D; Lolis E; Komives E A; Petsko G A
Crystal structure of the K12M/G15A triosephosphate isomerase double mutant and electrostatic analysis of the active site.
Biochemistry 1994;33(10):2815-23.
1994: Lodi P J; Chang L C; Knowles J R; Komives E A
Triosephosphate isomerase requires a positively charged active site: the role of lysine-12.
Biochemistry 1994;33(10):2809-14.
1994: Joseph-McCarthy D; Rost L E; Komives E A; Petsko G A
Crystal structure of the mutant yeast triosephosphate isomerase in which the catalytic base glutamic acid 165 is changed to aspartic acid.
Biochemistry 1994;33(10):2824-9.
1992: Warn-Cramer B J; Broze G J; Komives E A
cDNA sequence of rabbit tissue factor pathway inhibitor.
Nucleic acids research 1992;20(13):3548.
1991: Komives E A; Chang L C; Lolis E; Tilton R F; Petsko G A; Knowles J R
Electrophilic catalysis in triosephosphate isomerase: the role of histidine-95.
Biochemistry 1991;30(12):3011-9.

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